Skip to main content
Photo of  Traian D. Ionascu, PhD

Traian D. Ionascu, PhD

Associate Professor of Clinical

Radiation Oncology | College of Medicine

  • Posdoctoral Fellowship: Harvard Medical School (Medical Physics-Radiation Oncology)
  • Doctoral Degree: Northeastern University (Physics)
  • Master's Degree: Northeastern University (Physics)
  • Master's Degree: University of Bucharest (Physics)
  • Bachelor's Degree: University of Bucharest (Physics)
Contact Information
Research Interests

Radiation Physics
Treatment Planning
Tumor Tracking
Advanced Imaging Techniques
Pre-clinical Radiation Research and Radiobiology
Vibrational Coherence Spectroscopy
Biomolecule Dynamics
Optics and Microscopy

Peer Reviewed Publications

Kennedy, Sonya R; Lafond, Maxime; Haworth, Kevin J; Escudero, Daniel Suarez; Ionascu, Dan; Frierson, Brion; Huang, Shaoling; Klegerman, Melvin E; Peng, Tao; McPherson, David D; Genstler, Curtis; Holland, Christy K 2023. Initiating and imaging cavitation from infused echo contrast agents through the EkoSonic catheter. Scientific reports, 13 1, 6191

Dhou, Salam; Alkhodari, Mohanad; Ionascu, Dan; Williams, Christopher; Lewis, John H 2022. Fluoroscopic 3D Image Generation from Patient-Specific PCA Motion Models Derived from 4D-CBCT Patient Datasets: A Feasibility Study. Journal of imaging, 8 2,

Dhou, Salam; Lewis, John; Cai, Weixing; Ionascu, Dan; Williams, Christopher 2020. Quantifying day-to-day variations in 4DCBCT-based PCA motion models. Biomedical physics & engineering express, 6 3, 035020

Pomeranz Krummel, Daniel A; Nasti, Tahseen H; Kaluzova, Milota; Kallay, Laura; Bhattacharya, Debanjan; Melms, Johannes C; Izar, Benjamin; Xu, Maxwell; Burnham, Andre; Ahmed, Taukir; Li, Guanguan; Lawson, David; Kowalski, Jeanne; Cao, Yichun; Switchenko, Jeffrey M; Ionascu, Dan; Cook, James M; Medvedovic, Mario; Jenkins, Andrew; Khan, Mohammad K; Sengupta, Soma 2020. Melanoma Cell Intrinsic GABAA Receptor Enhancement Potentiates Radiation and Immune Checkpoint Inhibitor Response by Promoting Direct and T Cell-Mediated Antitumor Activity. International journal of radiation oncology, biology, physics, ,

Sertorio, Mathieu; Nowrouzi, Ali; Akbarpour, Mahdi; Chetal, Kashish; Salomonis, Nathan; Brons, Stephan; Mascia, Anthony; Ionascu, Dan; Shelby McCauley, ; Kupneski, Taylor; Köthe, Andreas; Debus, Jürgen; Perentesis, John P; Abdollahi, Amir; Zheng, Yi; Wells, Susanne I 2020. Differential transcriptome response to proton versus X-ray radiation reveals novel candidate targets for combinatorial PT therapy in lymphoma. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, ,

Guo, Minghao; Chee, Geraldine; O'Connell, Dylan; Dhou, Salam; Fu, Jie; Singhrao, Kamal; Ionascu, Dan; Ruan, Dan; Lee, Percy; Low, Daniel A; Zhao, Jun; Lewis, John H 2019. Reconstruction of a high-quality volumetric image and a respiratory motion model from patient CBCT projections. Medical physics, 46 8, 3627-3639

Qin, An; Ionascu, Dan; Liang, Jian; Han, Xiao; O'Connell, Nicolette; Yan, Di 2018. The evaluation of a hybrid biomechanical deformable registration method on a multistage physical phantom with reproducible deformation. Radiation oncology (London, England), 13 1, 240

Dhou, S; Hurwitz, M; Mishra, P; Cai, W; Rottmann, J; Li, R; Williams, C; Wagar, M; Berbeco, R; Ionascu, D; Lewis, J H 2015. 3D fluoroscopic image estimation using patient-specific 4DCBCT-based motion models. Physics in medicine and biology, 60 9, 3807-24

Mangona, Victor S; Aneese, Andrew M; Marina, Ovidiu; Hymas, Richard V; Ionascu, Dan; Robertson, John M; Gallardo, Lori J; Grills, Inga Siiner 2015. Toxicity after central versus peripheral lung stereotactic body radiation therapy: a propensity score matched-pair analysis. International journal of radiation oncology, biology, physics, 91 1, 124-32

Zhuang, Ling; Yan, Di; Liang, Jian; Ionascu, Dan; Mangona, Victor; Yang, Kai; Zhou, Jun 2014. Evaluation of image guided motion management methods in lung cancer radiotherapy. Medical physics, 41 3, 031911

Kim, Joshua; Ionascu, Dan; Zhang, Tiezhi 2013. Technical note: algebraic iterative image reconstruction using a cylindrical image grid for tetrahedron beam computed tomography. Medical physics, 40 8, 081909

Zhuang, Ling; Liang, Jian; Yan, Di; Zhang, Tiezhi; Marina, Ovidiu; Ionascu, Dan 2013. An optimization algorithm for 3D real-time lung tumor tracking during arc therapy using kV projection images. Medical physics, 40 10, 101710

Mohammed, Nasiruddin; Kestin, Larry; Grills, Inga; Shah, Chirag; Glide-Hurst, Carri; Yan, Di; Ionascu, Dan 2012. Comparison of IGRT registration strategies for optimal coverage of primary lung tumors and involved nodes based on multiple four-dimensional CT scans obtained throughout the radiotherapy course. International journal of radiation oncology, biology, physics, 82 4, 1541-8

Glide-Hurst, Carri K; Ionascu, Dan; Berbeco, Ross; Yan, Di 2011. Coupling surface cameras with on-board fluoroscopy: a feasibility study. Medical physics, 38 6, 2937-47

Killoran, Joseph H; Gerbaudo, Victor H; Mamede, Marcelo; Ionascu, Dan; Park, Sang-June; Berbeco, Ross 2011. Motion artifacts occurring at the lung/diaphragm interface using 4D CT attenuation correction of 4D PET scans. Journal of applied clinical medical physics, 12 4, 3502

Court, Laurence E; Seco, Joao; Lu, Xing-Qi; Ebe, Kazuyu; Mayo, Charles; Ionascu, Dan; Winey, Brian; Giakoumakis, Nikos; Aristophanous, Michalis; Berbeco, Ross; Rottman, Joerg; Bogdanov, Madeleine; Schofield, Deborah; Lingos, Tania 2010. Use of a realistic breathing lung phantom to evaluate dose delivery errors. Medical physics, 37 11, 5850-7

Court, Laurence; Wagar, Matthew; Berbeco, Ross; Reisner, Adam; Winey, Brian; Schofield, Debbie; Ionascu, Dan; Allen, Aaron M; Popple, Richard; Lingos, Tania 2010. Evaluation of the interplay effect when using RapidArc to treat targets moving in the craniocaudal or right-left direction. Medical physics, 37 1, 4-11

Court, Laurence; Wagar, Matthew; Bogdanov, Madeleine; Ionascu, Dan; Schofield, Deborah; Allen, Aaron; Berbeco, Ross; Lingos, Tania 2010. Use of reduced dose rate when treating moving tumors using dynamic IMRT. Journal of applied clinical medical physics, 12 1, 3276

Park, Sang-June; Ionascu, Dan; Hacker, Fred; Mamon, Harvey; Berbeco, Ross 2009. Automatic marker detection and 3D position reconstruction using cine EPID images for SBRT verification. Medical physics, 36 10, 4536-46

Berbeco, Ross I; Hacker, Fred; Zatwarnicki, Chris; Park, Sang-June; Ionascu, Dan; O'Farrell, Desmond; Mamon, Harvey J 2008. A novel method for estimating SBRT delivered dose with beam's-eye-view images. Medical physics, 35 7, 3225-31

Court, Laurence E; Wagar, Matthew; Ionascu, Dan; Berbeco, Ross; Chin, Lee 2008. Management of the interplay effect when using dynamic MLC sequences to treat moving targets. Medical physics, 35 5, 1926-31

Gruia, Flaviu; Ionascu, Dan; Kubo, Minoru; Ye, Xiong; Dawson, John; Osborne, Robert L; Sligar, S G; Denisov, Ilia; Das, Aditi; Poulos, T L; Terner, James; Champion, Paul M 2008. Low-frequency dynamics of Caldariomyces fumago chloroperoxidase probed by femtosecond coherence spectroscopy. Biochemistry, 47 18, 5156-67

Gruia, Flaviu; Kubo, Minoru; Ye, Xiong; Ionascu, Dan; Lu, Changyuan; Poole, Robert K; Yeh, Syun-Ru; Champion, Paul M 2008. Coherence spectroscopy investigations of the low-frequency vibrations of heme: effects of protein-specific perturbations. Journal of the American Chemical Society, 130 15, 5231-44

Park, Sang-June; Ionascu, Dan; Killoran, Joseph; Mamede, Marcelo; Gerbaudo, Victor H; Chin, Lee; Berbeco, Ross 2008. Evaluation of the combined effects of target size, respiratory motion and background activity on 3D and 4D PET/CT images. Physics in medicine and biology, 53 13, 3661-79

Berbeco, Ross I; Hacker, Fred; Ionascu, Dan; Mamon, Harvey J 2007. Clinical feasibility of using an EPID in CINE mode for image-guided verification of stereotactic body radiotherapy. International journal of radiation oncology, biology, physics, 69 1, 258-66

Gruia, Flaviu; Ye, Xiong; Ionascu, Dan; Kubo, Minoru; Champion, Paul M 2007. Low frequency spectral density of ferrous heme: perturbations induced by axial ligation and protein insertion. Biophysical journal, 93 12, 4404-13

Ionascu, Dan; Jiang, Steve B; Nishioka, Seiko; Shirato, Hiroki; Berbeco, Ross I 2007. Internal-external correlation investigations of respiratory induced motion of lung tumors. Medical physics, 34 10, 3893-903

Ye, Xiong; Ionascu, Dan; Gruia, Florin; Yu, Anchi; Benabbas, Abdelkrim; Champion, Paul M 2007. Temperature-dependent heme kinetics with nonexponential binding and barrier relaxation in the absence of protein conformational substates. Proceedings of the National Academy of Sciences of the United States of America, 104 37, 14682-7

Ionascu, Dan; Gruia, Flaviu; Ye, Xiong; Yu, Anchi; Rosca, Florin; Beck, Chris; Demidov, Andrey; Olson, John S; Champion, Paul M 2005. Temperature-dependent studies of NO recombination to heme and heme proteins. Journal of the American Chemical Society, 127 48, 16921-34

Ye, Xiong; Yu, Anchi; Georgiev, Georgi Y; Gruia, Florin; Ionascu, Dan; Cao, Wenxiang; Sage, J Timothy; Champion, Paul M 2005. CO rebinding to protoheme: investigations of the proximal and distal contributions to the geminate rebinding barrier. Journal of the American Chemical Society, 127 16, 5854-61

Champion, Paul M; Rosca, Florin; Ionascu, Dan; Cao, Wenxiang; Ye, Xiong 2004. Rapid timescale processes and the role of electronic surface coupling in the photolysis of diatomic ligands from heme proteins. Faraday discussions, 127 , 123-35