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Photo of  Nives G. Zimmermann, M.D.

Nives G. Zimmermann, M.D.

Associate Professor of Clinical

Pathology & Laboratory Medicine | College of Medicine

Education/Credentials
  • Medical Degree: University of Zagreb
  • Residency: University of Cincinnati College of Medicine
  • Fellowship: Indiana University
  • Fellowship: Cincinnati Children's Hospital Medical Center
Board Certifications & Licenses

American Board of Pathology (Anatomic and Clinical Pathology) (Certification Date: 20180621)
American Board of Pathology (Hematology) (Certification Date: 20190920)
American Board of Pathology (Pediatric Pathology) (Certification Date: 20200923)

Languages

Croatian

Specialties

Hematopathology
Pathology-Anatomic and Clinical
Pediatric Pathology

Contact Information
Research Interests

Hematopathology

Clinical Interests

Pathology

Peer Reviewed Publications

O'Shea, Kelly M; Rochman, Mark; Shoda, Tetsuo; Zimmermann, Nives; Caldwell, Julie; Rothenberg, Marc E 2020. Eosinophilic esophagitis with extremely high esophageal eosinophil counts. The Journal of allergy and clinical immunology, ,

Zimmermann, Nives; Nassiri, Mehdi; Zhou, Jiehao; Miller, Adam M; Zhang, Shanxiang 2020. Myeloid neoplasm with a novel cryptic PDGFRB rearrangement detected by next-generation sequencing. Cancer genetics, 244 , 55-59

Criss, Benjamin E; Zimmermann, Nives; Butler, Randall T 2019. Previously Unreported Complication of Coronary Artery Bypass Grafting: Suture Rupture Resulting in Patient's Death. Journal of forensic sciences, 64 1, 281-283

Legrand, Fanny; Cao, Yun; Wechsler, Joshua B; Zhu, Xiang; Zimmermann, Nives; Rampertaap, Shakuntala; Monsale, Joseph; Romito, Kimberly; Youngblood, Bradford A; Brock, Emily C; Makiya, Michelle A; Tomasevic, Nenad; Bebbington, Christopher; Maric, Irina; Metcalfe, Dean D; Bochner, Bruce S; Klion, Amy D 2019. Sialic acid-binding immunoglobulin-like lectin (Siglec) 8 in patients with eosinophilic disorders: Receptor expression and targeting using chimeric antibodies. The Journal of allergy and clinical immunology, 143 6, 2227-2237.e10

Prows, Daniel R; Klingler, Andrea; Gibbons, William J; Homan, Shelli M; Zimmermann, Nives 2019. Characterization of a mouse model of hypereosinophilia-associated heart disease. American journal of physiology. Heart and circulatory physiology, 317 2, H405-H414

Zimmermann, Nives; Gibbons, William J; Homan, Shelli M; Prows, Daniel R 2019. Heart disease in a mutant mouse model of spontaneous eosinophilic myocarditis maps to three loci. BMC genomics, 20 1, 727

Shoda, Tetsuo; Wen, Ting; Aceves, Seema S; Abonia, J Pablo; Atkins, Dan; Bonis, Peter A; Caldwell, Julie M; Capocelli, Kelley E; Carpenter, Christina L; Collins, Margaret H; Dellon, Evan S; Eby, Michael D; Gonsalves, Nirmala; Gupta, Sandeep K; Falk, Gary W; Hirano, Ikuo; Menard-Katcher, Paul; Kuhl, Jonathan T; Krischer, Jeffrey P; Leung, John; Mukkada, Vincent A; Spergel, Jonathan M; Trimarchi, Michael P; Yang, Guang-Yu; Zimmermann, Nives; Furuta, Glenn T; Rothenberg, Marc E 2018. Eosinophilic oesophagitis endotype classification by molecular, clinical, and histopathological analyses: a cross-sectional study. The lancet. Gastroenterology & hepatology, 3 7, 477-488

Zimmermann, Nives; Wikenheiser-Brokamp, Kathryn A 2018. Hypereosinophilic syndrome in the differential diagnosis of pulmonary infiltrates with eosinophilia. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 121 2, 179-185

Kano, Gen; Bochner, Bruce S; Zimmermann, Nives 2017. Regulation of Siglec-8-induced intracellular reactive oxygen species production and eosinophil cell death by Src family kinases. Immunobiology, 222 2, 343-349

Zimmermann, Nives; Stanek, Jerzy 2017. Perinatal Case of Fatal Simpson-Golabi-Behmel Syndrome with Hyperplasia of Seminiferous Tubules. The American journal of case reports, 18 , 649-655

Zhu, Xiang; Hogan, Simon Patrick; Molkentin, Jeffery D; Zimmermann, Nives 2016. Cyclophilin D Regulates Necrosis But Not Apoptosis of Murine Eosinophils. American journal of physiology. Gastrointestinal and liver physiology, , ajpgi.00389.2015

Bochner, Bruce S; Zimmermann, Nives 2015. Role of siglecs and related glycan-binding proteins in immune responses and immunoregulation. The Journal of allergy and clinical immunology, 135 3, 598-608

Zimmermann, Nives; Hagen, Matthew C; Schrager, Jason J; Hebbeler-Clark, Renee S; Masineni, Sreeharsha 2015. Utility of frozen section analysis for fungal organisms in soft tissue wound debridement margin determination. Diagnostic pathology, 10 , 188

Zimmermann, Nives; Rothenberg, Marc E 2015. Mechanism of enhanced eosinophil survival in inflammation. Blood, 125 25, 3831-2

Wen, Ting; Mingler, Melissa K; Wahl, Benjamin; Khorki, M Eyad; Pabst, Oliver; Zimmermann, Nives; Rothenberg, Marc E 2014. Carbonic anhydrase IV is expressed on IL-5-activated murine eosinophils. Journal of immunology (Baltimore, Md. : 1950), 192 12, 5481-9

Zhu, Xiang; Mose, Eucabeth; Hogan, Simon P; Zimmermann, Nives 2014. Differential eosinophil and mast cell regulation: mast cell viability and accumulation in inflammatory tissue are independent of proton-sensing receptor GPR65. American journal of physiology. Gastrointestinal and liver physiology, 306 11, G974-82

Collison, Adam; Hatchwell, Luke; Verrills, Nicole; Wark, Peter A B; de Siqueira, Ana Pereira; Tooze, Melinda; Carpenter, Helen; Don, Anthony S; Morris, Jonathan C; Zimmermann, Nives; Bartlett, Nathan W; Rothenberg, Marc E; Johnston, Sebastian L; Foster, Paul S; Mattes, Joerg 2013. The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity. Nature medicine, 19 2, 232-7

Epstein, Tolly G; Kesavalu, Banurekha; Bernstein, Cheryl K; Ryan, Patrick H; Bernstein, Jonathan A; Zimmermann, Nives; Lummus, Zana; Villareal, Manuel S; Smith, Andrew M; Lenz, Peter H; Bernstein, David I 2013. Chronic traffic pollution exposure is associated with eosinophilic, but not neutrophilic inflammation in older adult asthmatics. The Journal of asthma : official journal of the Association for the Care of Asthma, 50 9, 983-9

Kano, Gen; Almanan, Maha; Bochner, Bruce S; Zimmermann, Nives 2013. Mechanism of Siglec-8-mediated cell death in IL-5-activated eosinophils: role for reactive oxygen species-enhanced MEK/ERK activation. The Journal of allergy and clinical immunology, 132 2, 437-45

Mao, Hui; Kano, Gen; Hudson, Sherry A; Brummet, Mary; Zimmermann, Nives; Zhu, Zhou; Bochner, Bruce S 2013. Mechanisms of Siglec-F-induced eosinophil apoptosis: a role for caspases but not for SHP-1, Src kinases, NADPH oxidase or reactive oxygen. PloS one, 8 6, e68143

Zhu, Xiang; Mose, Eucabeth; Zimmermann, Nives 2013. Proton channel HVCN1 is required for effector functions of mouse eosinophils. BMC immunology, 14 , 24

Arumugam, Muthuvel; Ahrens, Richard; Osterfeld, Heather; Kottyan, Leah C; Shang, Xun; Maclennan, John A; Zimmermann, Nives; Zheng, Yi; Finkelman, Fred D; Hogan, Simon P 2011. Increased susceptibility of 129SvEvBrd mice to IgE-Mast cell mediated anaphylaxis. BMC immunology, 12 , 14

Lacy, Paige; Willetts, Lian; Kim, John D; Lo, Andrea N; Lam, Bon; Maclean, Emily I; Moqbel, Redwan; Rothenberg, Marc E; Zimmermann, Nives 2011. Agonist activation of f-actin-mediated eosinophil shape change and mediator release is dependent on Rac2. International archives of allergy and immunology, 156 2, 137-47

Gao, Pei-Song; Shimizu, Kenichi; Grant, Audrey V; Rafaels, Nicholas; Zhou, Lin-Fu; Hudson, Sherry A; Konno, Satoshi; Zimmermann, Nives; Araujo, Maria I; Ponte, Eduardo V; Cruz, Alvaro A; Nishimura, Masaharu; Su, Song-Nan; Hizawa, Nobuyuki; Beaty, Terry H; Mathias, Rasika A; Rothenberg, Marc E; Barnes, Kathleen C; Bochner, Bruce S 2010. Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma. European journal of human genetics : EJHG, 18 6, 713-9

Herbert, De'Broski R; Orekov, Tatyana; Roloson, Amanda; Ilies, Monica; Perkins, Charles; O'Brien, William; Cederbaum, Stephen; Christianson, David W; Zimmermann, Nives; Rothenberg, Marc E; Finkelman, Fred D 2010. Arginase I suppresses IL-12/IL-23p40-driven intestinal inflammation during acute schistosomiasis. Journal of immunology (Baltimore, Md. : 1950), 184 11, 6438-46

Niese, Kathryn A; Chiaramonte, Monica G; Ellies, Lesley G; Rothenberg, Marc E; Zimmermann, Nives 2010. The cationic amino acid transporter 2 is induced in inflammatory lung models and regulates lung fibrosis. Respiratory research, 11 , 87

Kottyan, Leah C; Collier, Ann R; Cao, Khanh H; Niese, Kathryn A; Hedgebeth, Megan; Radu, Caius G; Witte, Owen N; Khurana Hershey, Gurjit K; Rothenberg, Marc E; Zimmermann, Nives 2009. Eosinophil viability is increased by acidic pH in a cAMP- and GPR65-dependent manner. Blood, 114 13, 2774-82

Niese, Kathryn A; Collier, Ann R; Hajek, Amanda R; Cederbaum, Stephen D; O'Brien, William E; Wills-Karp, Marsha; Rothenberg, Marc E; Zimmermann, Nives 2009. Bone marrow cell derived arginase I is the major source of allergen-induced lung arginase but is not required for airway hyperresponsiveness, remodeling and lung inflammatory responses in mice. BMC immunology, 10 , 33

Bergeron, CĂ©line; Boulet, Louis-Philippe; Page, Nathalie; Laviolette, Michel; Zimmermann, Nives; Rothenberg, Marc E; Hamid, Qutayba 2007. Influence of cigarette smoke on the arginine pathway in asthmatic airways: increased expression of arginase I. The Journal of allergy and clinical immunology, 119 2, 391-7

Rothenberg, Marc E; Doepker, Matthew P; Lewkowich, Ian P; Chiaramonte, Monica G; Stringer, Keith F; Finkelman, Fred D; MacLeod, Carol L; Ellies, Lesley G; Zimmermann, Nives 2006. Cationic amino acid transporter 2 regulates inflammatory homeostasis in the lung. Proceedings of the National Academy of Sciences of the United States of America, 103 40, 14895-900

Zimmermann, Nives; Rothenberg, Marc E 2006. The arginine-arginase balance in asthma and lung inflammation. European journal of pharmacology, 533 1-3, 253-62

Fulkerson, Patricia C; Zhu, Hongyan; Williams, David A; Zimmermann, Nives; Rothenberg, Marc E 2005. CXCL9 inhibits eosinophil responses by a CCR3- and Rac2-dependent mechanism. Blood, 106 2, 436-43

Pope, Samuel M; Fulkerson, Patricia C; Blanchard, Carine; Akei, Hiroko Saito; Nikolaidis, Nikolaos M; Zimmermann, Nives; Molkentin, Jeffery D; Rothenberg, Marc E 2005. Identification of a cooperative mechanism involving interleukin-13 and eotaxin-2 in experimental allergic lung inflammation. The Journal of biological chemistry, 280 14, 13952-61

Pope, Samuel M; Zimmermann, Nives; Stringer, Keith F; Karow, Margaret L; Rothenberg, Marc E 2005. The eotaxin chemokines and CCR3 are fundamental regulators of allergen-induced pulmonary eosinophilia. Journal of immunology (Baltimore, Md. : 1950), 175 8, 5341-50

Zimmermann, Nives; Colyer, Jessica L; Koch, Laura E; Rothenberg, Marc E 2005. Analysis of the CCR3 promoter reveals a regulatory region in exon 1 that binds GATA-1. BMC immunology, 6 , 7

Zimmermann, Nives; Doepker, Matthew P; Witte, David P; Stringer, Keith F; Fulkerson, Patricia C; Pope, Samuel M; Brandt, Eric B; Mishra, Anil; King, Nina E; Nikolaidis, Nikolaos M; Wills-Karp, Marsha; Finkelman, Fred D; Rothenberg, Marc E 2005. Expression and regulation of small proline-rich protein 2 in allergic inflammation. American journal of respiratory cell and molecular biology, 32 5, 428-35

Fulkerson, Patricia C; Zimmermann, Nives; Brandt, Eric B; Muntel, Emily E; Doepker, Matthew P; Kavanaugh, Jessica L; Mishra, Anil; Witte, David P; Zhang, Hongwei; Farber, Joshua M; Yang, Ming; Foster, Paul S; Rothenberg, Marc E 2004. Negative regulation of eosinophil recruitment to the lung by the chemokine monokine induced by IFN-gamma (Mig, CXCL9). Proceedings of the National Academy of Sciences of the United States of America, 101 7, 1987-92

Fulkerson, Patricia C; Zimmermann, Nives; Hassman, Lynn M; Finkelman, Fred D; Rothenberg, Marc E 2004. Pulmonary chemokine expression is coordinately regulated by STAT1, STAT6, and IFN-gamma. Journal of immunology (Baltimore, Md. : 1950), 173 12, 7565-74

King, Nina E; Rothenberg, Marc E; Zimmermann, Nives 2004. Arginine in asthma and lung inflammation. The Journal of nutrition, 134 10 Suppl, 2830S-2836S; discuss

King, Nina E; Zimmermann, Nives; Pope, Samuel M; Fulkerson, Patricia C; Nikolaidis, Nikolaos M; Mishra, Anil; Witte, David P; Rothenberg, Marc E 2004. Expression and regulation of a disintegrin and metalloproteinase (ADAM) 8 in experimental asthma. American journal of respiratory cell and molecular biology, 31 3, 257-65

Zimmermann, Nives; Mishra, Anil; King, Nina E; Fulkerson, Patricia C; Doepker, Matthew P; Nikolaidis, Nikolaos M; Kindinger, Laura E; Moulton, Elizabeth A; Aronow, Bruce J; Rothenberg, Marc E 2004. Transcript signatures in experimental asthma: identification of STAT6-dependent and -independent pathways. Journal of immunology (Baltimore, Md. : 1950), 172 3, 1815-24

Aizawa, Hideyuki; Zimmermann, Nives; Carrigan, Patricia E; Lee, James J; Rothenberg, Marc E; Bochner, Bruce S 2003. Molecular analysis of human Siglec-8 orthologs relevant to mouse eosinophils: identification of mouse orthologs of Siglec-5 (mSiglec-F) and Siglec-10 (mSiglec-G). Genomics, 82 5, 521-30

Brandt, Eric B; Strait, Richard T; Hershko, Dan; Wang, Quan; Muntel, Emily E; Scribner, Troy A; Zimmermann, Nives; Finkelman, Fred D; Rothenberg, Marc E 2003. Mast cells are required for experimental oral allergen-induced diarrhea. The Journal of clinical investigation, 112 11, 1666-77

Nikolaidis, Nikolaos M; Zimmermann, Nives; King, Nina E; Mishra, Anil; Pope, Samuel M; Finkelman, Fred D; Rothenberg, Marc E 2003. Trefoil factor-2 is an allergen-induced gene regulated by Th2 cytokines and STAT6 in the lung. American journal of respiratory cell and molecular biology, 29 4, 458-64

Yang, Ming; Hogan, Simon P; Mahalingam, Surendran; Pope, Sam M; Zimmermann, Nives; Fulkerson, Patricia; Dent, Lindsay A; Young, Ian G; Matthaei, Klaus I; Rothenberg, Marc E; Foster, Paul S 2003. Eotaxin-2 and IL-5 cooperate in the lung to regulate IL-13 production and airway eosinophilia and hyperreactivity. The Journal of allergy and clinical immunology, 112 5, 935-43

Zimmermann, Nives; Hershey, Gurjit Khurana; Foster, Paul S; Rothenberg, Marc E 2003. Chemokines in asthma: cooperative interaction between chemokines and IL-13. The Journal of allergy and clinical immunology, 111 2, 227-42; quiz 243

Zimmermann, Nives; King, Nina E; Laporte, Johanne; Yang, Ming; Mishra, Anil; Pope, Sam M; Muntel, Emily E; Witte, David P; Pegg, Anthony A; Foster, Paul S; Hamid, Qutayba; Rothenberg, Marc E 2003. Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis. The Journal of clinical investigation, 111 12, 1863-74

Zimmermann, Nives; Rothenberg, Marc E 2003. Receptor internalization is required for eotaxin-induced responses in human eosinophils. The Journal of allergy and clinical immunology, 111 1, 97-105

Hecht, D; Zimmerman, N; Bedford, M; Avivi, A; Yayon, A 1995. Identification of fibroblast growth factor 9 (FGF9) as a high affinity, heparin dependent ligand for FGF receptors 3 and 2 but not for FGF receptors 1 and 4. Growth factors (Chur, Switzerland), 12 3, 223-33

Zimmermann N.; Hogan S.; Mishra A.; Brandt E.; Bodette T.; Pope S.; Finkelman F.; Rothenberg M. 11-15-2000. Murine eotaxin-2: A constitutive eosinophil chemokine induced by allergen challenge and IL-4 overexp Journal of Immunology, 165 10, 5839-5846

Zimmermann N.; Bernstein J.; Rothenberg M. 11-08-1998. Polymorphisms in the human CC chemokine receptor-3 gene Biochimica et Biophysica Acta - Gene Structure and Expression, 1442 2-3, 170-176

Rothenberg M.E.; Zimmermann N.; Mishra A.; Brandt E.; Birkenberger L.A.; Hogan S.P.; Foster P.S. 10-28-1999. Chemokines and chemokine receptors: Their role in allergic airway disease Journal of Clinical Immunology, 19 5, 250-265

Zimmermann N.; Daugherty B.L.; Kavanaugh J.L.; El-Awar F.Y.; Moulton E.A.; Rothenberg M.E. 10-01-2000. Analysis of the CC chemokine receptor 3 gene reveals a complex 5' exon organization, a functional ro Blood, 96 7, 2346-2354

Zimmermann N.; McBride M.; Yamada Y.; Hudson S.; Jones C.; Cromie K.; Crocker P.; Rothenberg M.; Bochner B. 09-01-2008. Siglec-F antibody administration to mice selectively reduces blood and tissue eosinophils Allergy: European Journal of Allergy and Clinical Immunology, 63 9, 1156-1163

Zimmermann N.; Cavanaugh P.F.; Doney M.K.; Haq N.; Gluckman J.L.; Pavelic Z.P. 08-15-1997. Development of a MIMIC-based polymerase chain reaction technique for the analysis of prostaglandin e Analytical Biochemistry, 251 1, 110-113

Matthews A.; Friend D.; Zimmermann N.; Sarafi M.; Luster A.; Pearlman E.; Wert S.; Rothenberg M. 05-26-1998. Eotaxin is required for the baseline level of tissue eosinophils Proceedings of the National Academy of Sciences of the United States of America, 95 11, 6273-6278

Zimmermann N.; Conkright J.; Rothenberg M. 04-30-1999. CC chemokine receptor-3 undergoes prolonged ligand-induced internalization Journal of Biological Chemistry, 274 18, 12611-12618

Brandt E.; Zimmermann N.; Muntel E.; Yamada Y.; Pope S.; Mishra A.; Hogan S.; Rothenberg M. 04-01-2006. The ?4?7-integrin is dynamically expressed on murine eosinophils and involved in eosinophil traffick Clinical and Experimental Allergy, 36 4, 543-553

Hogan S.P.; Mishra A.; Brandt E.B.; Royalty M.P.; Pope S.M.; Zimmermann N.; Foster P.S.; Rothenberg M.E. 04-01-2001. A pathological function for eotaxin and eosinophils in eosinophilic gastrointestinal inflammation Nature Immunology, 2 4, 353-360

Guo J.; Nutku E.; Yokoi H.; Schnaar R.; Zimmermann N.; Bochner B. 03-01-2007. Siglec-8 and siglec-F: Inhibitory receptors on eosinophils, basophils, and mast cells Allergy and Clinical Immunology International, 19 2, 54-59

Zimmermann N.; Daugherty B.; Stark J.; Rothenberg M. 01-15-2000. Molecular analysis of CCR-3 events in eosinophilic cells Journal of Immunology, 164 2, 1055-1064

Zimmermann N.; Rothenberg M. 01-01-2003. Role of the eotaxin subfamily of chemokines in allergic eosinophilic inflammation Therapeutic Targets in Airway Inflammation, , 421-464

Pope S.M.; Pope S.M.; Brandt E.B.; Mishra A.; Hogan S.P.; Hogan S.P.; Zimmermann N.; Rothenberg M.E.; Matthaei K.I.; Foster P.S. 01-01-2001. IL-13 induces eosinophil recruitment into the lung by an IL-5- and eotaxin-dependent mechanism Journal of Allergy and Clinical Immunology, 108 4, 594-601

Assa'ad A.H.; Spicer R.L.; Nelson D.P.; Zimmermann N.; Rothenberg M.E. 01-01-2000. Hypereosinophilic syndromes Chemical Immunology, 76 , 208-229

Rosa-Rosa L.; Zimmermann N.; Bernstein J.; Rothenberg M.; Khurana Hershey G. 01-01-1999. The R576 IL-4 receptor allele correlates with asthma severity Journal of Allergy and Clinical Immunology, 104 5, 1008-1014

Pavelic Z.; Lasmar M.; Pavelic L.; Sorensen C.; Stambrook P.; Zimmermann N.; Gluckman J. 01-01-1996. Absence of retinoblastoma gene product in human primary oral cavity carcinomas European Journal of Cancer Part B: Oral Oncology, 32 5, 347-351