Education/CredentialsDoctoral Degree: Indiana UniversityFellowship: University of San Fransisco Contact Information Office 513-558-9152 Email huidy@ucmail.uc.edu Research InterestsLipid Metabolism, Atherosclerosis, Diabetes, Obesity, Vascular Biology Our research program focuses on three specific areas relating cholesterol metabolism with individual susceptibility for coronary heart disease. Particular emphasis is placed on the genetic factors that are important for regulation of cholesterol transport and in the maintenance of cell functions in the arterial wall. One area of research uses induced mutant mice (transgenic and knockout mice... Peer Reviewed Publications Davidson, W S; Inge, T H; Sexmith, H; Heink, A; Elder, D; Hui, D Y; Melchior, J T; Kelesidis, T; Shah, A S 2017. Weight loss surgery in adolescents corrects high-density lipoprotein subspecies and their function. International journal of obesity (2005), 41 1, 83-89Hui, David Y 2017. The good side of cholesterol: a requirement for maintenance of intestinal integrity. Journal of lipid research, 58 10, 1935-1936Konaniah, Eddy S; Kuhel, David G; Basford, Joshua E; Weintraub, Neal L; Hui, David Y 2017. Deficiency of LRP1 in Mature Adipocytes Promotes Diet-Induced Inflammation and Atherosclerosis-Brief Report. Arteriosclerosis, thrombosis, and vascular biology, 37 6, 1046-1049Yiew, Nicole K H; Chatterjee, Tapan K; Tang, Yao Liang; Pellenberg, Rod; Stansfield, Brian K; Bagi, Zsolt; Fulton, David J; Stepp, David W; Chen, Weiqin; Patel, Vijay; Kamath, Vinayak M; Litwin, Sheldon E; Hui, David Y; Rudich, Steven M; Kim, Ha Won; Weintraub, Neal L 2017. A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity. The Journal of biological chemistry, 292 15, 6312-6324Cash, J G; Hui, D Y 2016. Liver-specific overexpression of LPCAT3 reduces postprandial hyperglycemia and improves lipoprotein metabolic profile in mice. Nutrition & diabetes, 6 , e206Goodson, M L; Packard, A E B; Buesing, D R; Maney, M; Myers, B; Fang, Y; Basford, J E; Hui, D Y; Ulrich-Lai, Y M; Herman, J P; Ryan, K K 2016. Chronic stress and Rosiglitazone increase indices of vascular stiffness in male rats. Physiology & behavior, , Hamlin, Allyson Naugle; Basford, Joshua E; Jaeschke, Anja; Hui, David Y 2016. Low density lipoprotein receptor-related protein-1 deficiency exacerbates palmitate-induced steatosis and toxicity in hepatocytes. The Journal of biological chemistry, , Hui, David Y 2016. Intestinal phospholipid and lysophospholipid metabolism in cardiometabolic disease. Current opinion in lipidology, 27 5, 507-12Lee, Wan Ru; Sacharidou, Anastasia; Behling-Kelly, Erica; Oltmann, Sarah C; Zhu, Weifei; Ahmed, Mohamed; Gerard, Robert D; Hui, David Y; Abe, Jun-ichi; Shaul, Philip W; Mineo, Chieko 2015. PDZK1 prevents neointima formation via suppression of breakpoint cluster region kinase in vascular smooth muscle. PloS one, 10 4, e0124494Unruh, Dusten; Srinivasan, Ramprasad; Benson, Tyler; Haigh, Stephen; Coyle, Danielle; Batra, Neil; Keil, Ryan; Sturm, Robert; Blanco, Victor; Palascak, Mary; Franco, Robert S; Tong, Wilson; Chatterjee, Tapan; Hui, David Y; Davidson, W Sean; Aronow, Bruce J; Kalfa, Theodosia; Manka, David; Peairs, Abigail; Blomkalns, Andra; Fulton, David J; Brittain, Julia E; Weintraub, Neal L; Bogdanov, Vladimir Y 2015. Red Blood Cell Dysfunction Induced by High-Fat Diet: Potential Implications for Obesity-Related Atherosclerosis. Circulation, 132 20, 1898-908Yiew, Kan Hui; Chatterjee, Tapan K; Hui, David Y; Weintraub, Neal L 2015. Histone Deacetylases and Cardiometabolic Diseases. Arteriosclerosis, thrombosis, and vascular biology, 35 9, 1914-9Chatterjee, Tapan K; Basford, Joshua E; Knoll, Ellen; Tong, Wilson S; Blanco, Victor; Blomkalns, Andra L; Rudich, Steven; Lentsch, Alex B; Hui, David Y; Weintraub, Neal L 2014. HDAC9 knockout mice are protected from adipose tissue dysfunction and systemic metabolic disease during high-fat feeding. Diabetes, 63 1, 176-87Gadang, Vidya; Konaniah, Eddy; Hui, David Y; Jaeschke, Anja 2014. Mixed-Lineage Kinase 3 Deficiency Promotes Neointima Formation Through Increased Activation of the RhoA Pathway in Vascular Smooth Muscle Cells. Arteriosclerosis, thrombosis, and vascular biology, 34 7, 1429-36Hollie, Norris I; Cash, James G; Matlib, M Abdul; Wortman, Matthew; Basford, Joshua E; Abplanalp, William; Hui, David Y 2014. Micromolar changes in lysophosphatidylcholine concentration cause minor effects on mitochondrial permeability but major alterations in function. Biochimica et biophysica acta, 1841 6, 888-95Hollie, Norris I; Konaniah, Eddy S; Goodin, Colleen; Hui, David Y 2014. Group 1B phospholipase A? inactivation suppresses atherosclerosis and metabolic diseases in LDL receptor-deficient mice. Atherosclerosis, 234 2, 377-80Manka, David; Chatterjee, Tapan K; Stoll, Lynn L; Basford, Joshua E; Konaniah, Eddy S; Srinivasan, Ramprasad; Bogdanov, Vladimir Y; Tang, Yaoliang; Blomkalns, Andra L; Hui, David Y; Weintraub, Neal L 2014. Transplanted Perivascular Adipose Tissue Accelerates Injury-Induced Neointimal Hyperplasia: Role of Monocyte Chemoattractant Protein-1. Arteriosclerosis, thrombosis, and vascular biology, , Manoharan, Palanikumar; Basford, Joshua E; Pilcher-Roberts, Robyn; Neumann, Jonathan; Hui, David Y; Lingrel, Jerry B 2014. Reduced levels of microRNAs miR-124a and miR-150 are associated with increased proinflammatory mediator expression in Krüppel-like factor 2 (KLF2)-deficient macrophages. The Journal of biological chemistry, 289 45, 31638-46Omar, Abdullah; Chatterjee, Tapan K; Tang, Yaoliang; Hui, David Y; Weintraub, Neal L 2014. Proinflammatory Phenotype of Perivascular Adipocytes. Arteriosclerosis, thrombosis, and vascular biology, , Ulrich, Victoria; Konaniah, Eddy S; Herz, Joachim; Gerard, Robert D; Jung, Eunjeong; Yuhanna, Ivan S; Ahmed, Mohamed; Hui, David Y; Mineo, Chieko; Shaul, Philip W 2014. Genetic variants of ApoE and ApoER2 differentially modulate endothelial function. Proceedings of the National Academy of Sciences of the United States of America, 111 37, 13493-8Ulrich, Victoria; Konaniah, Eddy S; Lee, Wan-Ru; Khadka, Sadiksha; Shen, Yu-Min; Herz, Joachim; Salmon, Jane E; Hui, David Y; Shaul, Philip W; Mineo, Chieko 2014. Antiphospholipid antibodies attenuate endothelial repair and promote neointima formation in mice. Journal of the American Heart Association, 3 5, e001369Waltmann, Meaghan D; Basford, Joshua E; Konaniah, Eddy S; Weintraub, Neal L; Hui, David Y 2014. Apolipoprotein E receptor-2 deficiency enhances macrophage susceptibility to lipid accumulation and cell death to augment atherosclerotic plaque progression and necrosis. Biochimica et biophysica acta, , Wang, Fei; Kohan, Alison B; Dong, H Henry; Yang, Qing; Xu, Min; Huesman, Sarah; Lou, Danwen; Hui, David Y; Tso, Patrick 2014. Overexpression of apolipoprotein C-III decreases secretion of dietary triglyceride into lymph. Physiological reports, 2 3, e00247Basford, Joshua E; Koch, Sheryl; Anjak, Ahmad; Singh, Vivek P; Krause, Eric G; Robbins, Nathan; Weintraub, Neal L; Hui, David Y; Rubinstein, Jack 2013. Smooth muscle LDL receptor-related protein-1 deletion induces aortic insufficiency and promotes vascular cardiomyopathy in mice. PloS one, 8 11, e82026Chatterjee, Tapan K; Aronow, Bruce J; Tong, Wilson S; Manka, David; Tang, Yaoliang; Bogdanov, Vladimir Y; Unruh, Dusten; Blomkalns, Andra L; Piegore, Mark G; Weintraub, Daniel S; Rudich, Steven M; Kuhel, David G; Hui, David Y; Weintraub, Neal L 2013. Human coronary artery perivascular adipocytes overexpress genes responsible for regulating vascular morphology, inflammation, and hemostasis. Physiological genomics, 45 16, 697-709Gadang, Vidya; Kohli, Rohit; Myronovych, Andriy; Hui, David Y; Perez-Tilve, Diego; Jaeschke, Anja 2013. MLK3 promotes metabolic dysfunction induced by saturated fatty acid-enriched diet. American journal of physiology. Endocrinology and metabolism, 305 4, E549-56Kuhel, David G; Konaniah, Eddy S; Basford, Joshua E; McVey, Courtney; Goodin, Colleen T; Chatterjee, Tapan K; Weintraub, Neal L; Hui, David Y 2013. Apolipoprotein E2 accentuates postprandial inflammation and diet-induced obesity to promote hyperinsulinemia in mice. Diabetes, 62 2, 382-91Shen, Ling; Xiong, Ye; Wang, David Q-H; Howles, Philip; Basford, Joshua E; Wang, Jiang; Xiong, Yu Qing; Hui, David Y; Woods, Stephen C; Liu, Min 2013. Ginsenoside Rb1 reduces fatty liver by activating AMP-activated protein kinase in obese rats. Journal of lipid research, 54 5, 1430-8Wang, Daren; El-Amouri, Salim S; Dai, Mei; Kuan, Chia-Yi; Hui, David Y; Brady, Roscoe O; Pan, Dao 2013. Engineering a lysosomal enzyme with a derivative of receptor-binding domain of apoE enables delivery across the blood-brain barrier. Proceedings of the National Academy of Sciences of the United States of America, 110 8, 2999-3004Cash, James G; Kuhel, David G; Basford, Joshua E; Jaeschke, Anja; Chatterjee, Tapan K; Weintraub, Neal L; Hui, David Y 2012. Apolipoprotein E4 impairs macrophage efferocytosis and potentiates apoptosis by accelerating endoplasmic reticulum stress. The Journal of biological chemistry, 287 33, 27876-84Castañeda, Tamara R; Abplanalp, William; Um, Sung Hee; Pfluger, Paul T; Schrott, Brigitte; Brown, Kimberly; Grant, Erin; Carnevalli, Larissa; Benoit, Stephen C; Morgan, Donald A; Gilham, Dean; Hui, David Y; Rahmouni, Kamal; Thomas, George; Kozma, Sara C; Clegg, Deborah J; Tschöp, Matthias H 2012. Metabolic control by S6 kinases depends on dietary lipids. PloS one, 7 3, e32631Godby, Richard C; Van Den Berg, Yascha W; Srinivasan, Ramprasad; Sturm, Robert; Hui, David Y; Konieczny, Stephen F; Aronow, Bruce J; Ozhegov, Evgeny; Ruf, Wolfram; Versteeg, Henri H; Bogdanov, Vladimir Y 2012. Nonproteolytic properties of murine alternatively spliced tissue factor: implications for integrin-mediated signaling in murine models. Molecular medicine (Cambridge, Mass.), 18 , 771-9Howles, Philip N; Hui, David Y 2012. Physiological role of hepatic NPC1L1 in human cholesterol and lipoprotein metabolism: new perspectives and open questions. Journal of lipid research, 53 11, 2253-5Hui, David Y 2012. Phospholipase A(2) enzymes in metabolic and cardiovascular diseases. Current opinion in lipidology, 23 3, 235-40Lingrel, Jerry B; Pilcher-Roberts, Robyn; Basford, Joshua E; Manoharan, Palanikumar; Neumann, Jon; Konaniah, Eddy S; Srinivasan, Ramprasad; Bogdanov, Vladimir Y; Hui, David Y 2012. Myeloid-specific Krüppel-like factor 2 inactivation increases macrophage and neutrophil adhesion and promotes atherosclerosis. Circulation research, 110 10, 1294-302Liu, Min; Kuhel, David G; Shen, Ling; Hui, David Y; Woods, Stephen C 2012. Apolipoprotein E does not cross the blood-cerebrospinal fluid barrier, as revealed by an improved technique for sampling CSF from mice. American journal of physiology. Regulatory, integrative and comparative physiology, 303 9, R903-8Adams, Michelle R; Konaniah, Eddy; Cash, James G; Hui, David Y 2011. Use of NBD-cholesterol to identify a minor but NPC1L1-independent cholesterol absorption pathway in mouse intestine American journal of physiology. Gastrointestinal and liver physiology, 300 1, G164-9Basford, Joshua E; Wancata, Lauren; Hofmann, Susanna M; Silva, R A Gangani D; Davidson, W Sean; Howles, Philip N; Hui, David Y 2011. Hepatic Deficiency of Low Density Lipoprotein Receptor-related Protein-1 Reduces High Density Lipoprotein Secretion and Plasma Levels in Mice The Journal of biological chemistry, 286 15, 13079-87Chatterjee, Tapan K; Idelman, Gila; Blanco, Victor; Blomkalns, Andra L; Piegore, Mark G; Weintraub, Daniel S; Kumar, Santosh; Rajsheker, Srinivas; Manka, David; Rudich, Steven M; Tang, Yaoliang; Hui, David Y; Bassel-Duby, Rhonda; Olson, Eric N; Lingrel, Jerry B; Ho, Shuk-Mei; Weintraub, Neal L 2011. Histone deacetylase 9 is a negative regulator of adipogenic differentiation. The Journal of biological chemistry, 286 31, 27836-47Hollie, Norris I; Hui, David Y 2011. Group 1B phospholipase A? deficiency protects against diet-induced hyperlipidemia in mice. Journal of lipid research, 52 11, 2005-11Cash, J G; Kuhel, D G; Goodin, C; Hui, D Y 2010. Pancreatic acinar cell-specific overexpression of group 1B phospholipase A(2) exacerbates diet-induced obesity and insulin resistance in mice International journal of obesity (2005), , Chambliss, Ken L; Wu, Qian; Oltmann, Sarah; Konaniah, Eddy S; Umetani, Michihisa; Korach, Kenneth S; Thomas, Gail D; Mineo, Chieko; Yuhanna, Ivan S; Kim, Sung Hoon; Madak-Erdogan, Zeynep; Maggi, Adriana; Dineen, Sean P; Roland, Christina L; Hui, David Y; Brekken, Rolf A; Katzenellenbogen, John A; Katzenellenbogen, Benita S; Shaul, Philip W 2010. Non-nuclear estrogen receptor alpha signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice The Journal of clinical investigation, 120 7, 2319-30Labonté, Eric D; Pfluger, Paul T; Cash, James G; Kuhel, David G; Roja, Juan C; Magness, Daniel P; Jandacek, Ronald J; Tschöp, Matthias H; Hui, David Y 2010. Postprandial lysophospholipid suppresses hepatic fatty acid oxidation: the molecular link between group 1B phospholipase A2 and diet-induced obesity The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 24 7, 2516-24Nawrocki, Andrea R; Hofmann, Susanna M; Teupser, Daniel; Basford, Joshua E; Durand, Jorge L; Jelicks, Linda A; Woo, Connie W; Kuriakose, George; Factor, Stephen M; Tanowitz, Herbert B; Hui, David Y; Tabas, Ira; Scherer, Philipp E 2010. Lack of association between adiponectin levels and atherosclerosis in mice Arteriosclerosis, thrombosis, and vascular biology, 30 6, 1159-65Perez-Tilve, Diego; Hofmann, Susanna M; Basford, Joshua; Nogueiras, Ruben; Pfluger, Paul T; Patterson, James T; Grant, Erin; Wilson-Perez, Hilary E; Granholm, Norman A; Arnold, Myrtha; Trevaskis, James L; Butler, Andrew A; Davidson, William S; Woods, Stephen C; Benoit, Stephen C; Sleeman, Mark W; DiMarchi, Richard D; Hui, David Y; Tschöp, Matthias H 2010. Melanocortin signaling in the CNS directly regulates circulating cholesterol Nature neuroscience, 13 7, 877-82Qin, Zhenyu; Konaniah, Eddy S; Neltner, Bonnie; Nemenoff, Raphael A; Hui, David Y; Weintraub, Neal L 2010. Participation of ATP7A in macrophage mediated oxidation of LDL Journal of lipid research, 51 6, 1471-7Yang, Li; Li, Xiaoming; Ji, Yong; Kohan, Alison B; Wang, David Q-H; Howles, Philip N; Hui, David Y; Lai, Jianghua; Tso, Patrick 2010. Effect of ezetimibe on incretin secretion in response to the intestinal absorption of a mixed meal American journal of physiology. Gastrointestinal and liver physiology, 299 5, G1003-11Zhu, Yanjuan; Kodvawala, Ahmer; Hui, David Y 2010. Apolipoprotein E inhibits toll-like receptor (TLR)-3- and TLR-4-mediated macrophage activation through distinct mechanisms The Biochemical journal, 428 1, 47-54Basford, Joshua E; Moore, Zachary W Q; Zhou, Li; Herz, Joachim; Hui, David Y 2009. Smooth muscle LDL receptor-related protein-1 inactivation reduces vascular reactivity and promotes injury-induced neointima formation Arteriosclerosis, thrombosis, and vascular biology, 29 11, 1772-8Hui, D Y; Cope, M J; Labonté, E D; Chang, H-T; Shao, J; Goka, E; Abousalham, A; Charmot, D; Buysse, J 2009. The phospholipase A(2) inhibitor methyl indoxam suppresses diet-induced obesity and glucose intolerance in mice British journal of pharmacology, 157 7, 1263-9Pinkaew, Decha; Cho, Sung Gook; Hui, David Y; Wiktorowicz, John E; Hutadilok-Towatana, Nongporn; Mahabusarakam, Wilawan; Tonganunt, Moltira; Stafford, Lewis J; Phongdara, Amornrat; Liu, Mingyao; Fujise, Ken 2009. Morelloflavone blocks injury-induced neointimal formation by inhibiting vascular smooth muscle cell migration. Biochimica et biophysica acta, 1790 1, 31-9Faulkner, Loren E; Panagotopulos, Stacey E; Johnson, Jacob D; Woollett, Laura A; Hui, David Y; Witting, Scott R; Maiorano, J Nicholas; Davidson, W Sean 2008. An analysis of the role of a retroendocytosis pathway in ABCA1-mediated cholesterol efflux from macrophages. Journal of lipid research, 49 6, 1322-32Faulkner, Loren E; Panagotopulos, Stacey E; Johnson, Jacob D; Woollett, Laura A; Hui, David Y; Witting, Scott R; Maiorano, J Nicholas; Davidson, W Sean 2008. An analysis of the role of a retroendocytosis pathway in ABCA1-mediated cholesterol efflux from macrophages. Journal of lipid research, 49 6, 1322-32Hofmann, Susanna M; Perez-Tilve, Diego; Greer, Todd M; Coburn, Beth A; Grant, Erin; Basford, Joshua E; Tschöp, Matthias H; Hui, David Y 2008. Defective lipid delivery modulates glucose tolerance and metabolic response to diet in apolipoprotein E-deficient mice. Diabetes, 57 1, 5-12Hui, David Y 2008. Intimal hyperplasia in murine models. Current drug targets, 9 3, 251-60Hui, David Y; Labonté, Eric D; Howles, Philip N 2008. Development and physiological regulation of intestinal lipid absorption. III. Intestinal transporters and cholesterol absorption. American journal of physiology. Gastrointestinal and liver physiology, 294 4, G839-43Labonté, Eric D; Camarota, Lisa M; Rojas, Juan C; Jandacek, Ronald J; Gilham, Dean E; Davies, Joanna P; Ioannou, Yiannis A; Tso, Patrick; Hui, David Y; Howles, Philip N 2008. Reduced absorption of saturated fatty acids and resistance to diet-induced obesity and diabetes by ezetimibe-treated and Npc1l1-/- mice. American journal of physiology. Gastrointestinal and liver physiology, 295 4, G776-83Frolov, Andrey; Hui, David Y 2007. The modern art of atherosclerosis: a picture of colorful plants, cholesterol, and inflammation. Arteriosclerosis, thrombosis, and vascular biology, 27 3, 450-2Gilham, Dean; Labonté, Eric D; Rojas, Juan C; Jandacek, Ronald J; Howles, Philip N; Hui, David Y 2007. Carboxyl ester lipase deficiency exacerbates dietary lipid absorption abnormalities and resistance to diet-induced obesity in pancreatic triglyceride lipase knockout mice. The Journal of biological chemistry, 282 34, 24642-9Hofmann, Susanna M; Zhou, Li; Perez-Tilve, Diego; Greer, Todd; Grant, Erin; Wancata, Lauren; Thomas, Andrew; Pfluger, Paul T; Basford, Joshua E; Gilham, Dean; Herz, Joachim; Tschöp, Matthias H; Hui, David Y 2007. Adipocyte LDL receptor-related protein-1 expression modulates postprandial lipid transport and glucose homeostasis in mice. The Journal of clinical investigation, 117 11, 3271-82Hui, David Y 2007. A no-no for NonO and JNK in extracellular matrix homeostasis and vascular stability. Arteriosclerosis, thrombosis, and vascular biology, 27 8, 1677-8Kim, Ja-Young; van de Wall, Esther; Laplante, Mathieu; Azzara, Anthony; Trujillo, Maria E; Hofmann, Susanna M; Schraw, Todd; Durand, Jorge L; Li, Hua; Li, Guangyu; Jelicks, Linda A; Mehler, Mark F; Hui, David Y; Deshaies, Yves; Shulman, Gerald I; Schwartz, Gary J; Scherer, Philipp E 2007. Obesity-associated improvements in metabolic profile through expansion of adipose tissue. The Journal of clinical investigation, 117 9, 2621-37Labonté, Eric D; Howles, Philip N; Granholm, Norman A; Rojas, Juan C; Davies, Joanna P; Ioannou, Yiannis A; Hui, David Y 2007. Class B type I scavenger receptor is responsible for the high affinity cholesterol binding activity of intestinal brush border membrane vesicles. Biochimica et biophysica acta, 1771 9, 1132-9Nogueiras, Ruben; Wiedmer, Petra; Perez-Tilve, Diego; Veyrat-Durebex, Christelle; Keogh, Julia M; Sutton, Gregory M; Pfluger, Paul T; Castaneda, Tamara R; Neschen, Susanne; Hofmann, Susanna M; Howles, Philip N; Morgan, Donald A; Benoit, Stephen C; Szanto, Ildiko; Schrott, Brigitte; Schürmann, Annette; Joost, Hans-Georg; Hammond, Craig; Hui, David Y; Woods, Stephen C; Rahmouni, Kamal; Butler, Andrew A; Farooqi, I Sadaf; O'Rahilly, Stephen; Rohner-Jeanrenaud, Françoise; Tschöp, Matthias H 2007. The central melanocortin system directly controls peripheral lipid metabolism. The Journal of clinical investigation, 117 11, 3475-88Ting, Harold J; Stice, James P; Schaff, Ulrich Y; Hui, David Y; Rutledge, John C; Knowlton, Anne A; Passerini, Anthony G; Simon, Scott I 2007. Triglyceride-rich lipoproteins prime aortic endothelium for an enhanced inflammatory response to tumor necrosis factor-alpha. Circulation research, 100 3, 381-90Tschöp, Matthias H; Hui, David Y; Horvath, Tamas L 2007. Diet-induced leptin resistance: the heart of the matter. Endocrinology, 148 3, 921-3Davidson, W Sean; Ghering, Amy B; Beish, Lauren; Tubb, Matthew R; Hui, David Y; Pearson, Kevin 2006. The biotin-capture lipid affinity assay: a rapid method for determining lipid binding parameters for apolipoproteins. Journal of lipid research, 47 2, 440-9Labonté, Eric D; Kirby, R Jason; Schildmeyer, Nicholas M; Cannon, April M; Huggins, Kevin W; Hui, David Y 2006. Group 1B phospholipase A2-mediated lysophospholipid absorption directly contributes to postprandial hyperglycemia. Diabetes, 55 4, 935-41Hui, David Y; Basford, Joshua E 2005. Distinct signaling mechanisms for apoE inhibition of cell migration and proliferation. Neurobiology of aging, 26 3, 317-23Hui, David Y; Howles, Philip N 2005. Molecular mechanisms of cholesterol absorption and transport in the intestine. Seminars in cell & developmental biology, 16 2, 183-92Kodvawala, Ahmer; Ghering, Amy B; Davidson, W Sean; Hui, David Y 2005. Carboxyl ester lipase expression in macrophages increases cholesteryl ester accumulation and promotes atherosclerosis. The Journal of biological chemistry, 280 46, 38592-8Moore, Zachary W Q; Hui, David Y 2005. Apolipoprotein E inhibition of vascular hyperplasia and neointima formation requires inducible nitric oxide synthase. Journal of lipid research, 46 10, 2083-90Pham, Thomas; Kodvawala, Ahmer; Hui, David Y 2005. The receptor binding domain of apolipoprotein E is responsible for its antioxidant activity. Biochemistry, 44 20, 7577-82Camarota, Lisa M; Chapman, Jamie M; Hui, David Y; Howles, Philip N 2004. Carboxyl ester lipase cofractionates with scavenger receptor BI in hepatocyte lipid rafts and enhances selective uptake and hydrolysis of cholesteryl esters from HDL3. The Journal of biological chemistry, 279 26, 27599-606Herz, Joachim; Hui, David Y 2004. Lipoprotein receptors in the vascular wall. Current opinion in lipidology, 15 2, 175-81Hui, David Y 2004. Apolipoprotein E-induced cell signaling in the vessel wall. Reviews in endocrine & metabolic disorders, 5 4, 335-41Kirby, R Jason; Howles, Philip N; Hui, David Y 2004. Rate of gastric emptying influences dietary cholesterol absorption efficiency in selected inbred strains of mice. Journal of lipid research, 45 1, 89-98Moore, Zachary W Q; Zhu, Binghua; Kuhel, David G; Hui, David Y 2004. Vascular apolipoprotein e expression and recruitment from circulation to modulate smooth muscle cell response to endothelial denudation. The American journal of pathology, 164 6, 2109-16Huggins, Kevin W; Camarota, Lisa M; Howles, Philip N; Hui, David Y 2003. Pancreatic triglyceride lipase deficiency minimally affects dietary fat absorption but dramatically decreases dietary cholesterol absorption in mice. The Journal of biological chemistry, 278 44, 42899-905Hui, David Y 2003. Effects of HIV protease inhibitor therapy on lipid metabolism. Progress in lipid research, 42 2, 81-92Hui, David Y 2003. HIV protease inhibitors and atherosclerosis. The Journal of clinical investigation, 111 3, 317-8Riddle, Tara M; Fichtenbaum, Carl J; Hui, David Y 2003. Leptin replacement therapy but not dietary polyunsaturated fatty acid alleviates HIV protease inhibitor-induced dyslipidemia and lipodystrophy in mice. Journal of acquired immune deficiency syndromes (1999), 33 5, 564-70Zhu, Yanjuan; Hui, David Y 2003. Apolipoprotein E binding to low density lipoprotein receptor-related protein-1 inhibits cell migration via activation of cAMP-dependent protein kinase A. The Journal of biological chemistry, 278 38, 36257-63Huggins, Kevin W; Boileau, Amy C; Hui, David Y 2002. Protection against diet-induced obesity and obesity- related insulin resistance in Group 1B PLA2-deficient mice. American journal of physiology. Endocrinology and metabolism, 283 5, E994-E1001Hui, David Y; Howles, Philip N 2002. Carboxyl ester lipase: structure-function relationship and physiological role in lipoprotein metabolism and atherosclerosis. Journal of lipid research, 43 12, 2017-30Kirby, R Jason; Zheng, Shuqin; Tso, Patrick; Howles, Philip N; Hui, David Y 2002. Bile salt-stimulated carboxyl ester lipase influences lipoprotein assembly and secretion in intestine: a process mediated via ceramide hydrolysis. The Journal of biological chemistry, 277 6, 4104-9Kuhel, David G; Zhu, Binghua; Witte, David P; Hui, David Y 2002. Distinction in genetic determinants for injury-induced neointimal hyperplasia and diet-induced atherosclerosis in inbred mice. Arteriosclerosis, thrombosis, and vascular biology, 22 6, 955-60Panagotopulos, Stacey E; Witting, Scott R; Horace, Erica M; Hui, David Y; Maiorano, J Nicholas; Davidson, W Sean 2002. The role of apolipoprotein A-I helix 10 in apolipoprotein-mediated cholesterol efflux via the ATP-binding cassette transporter ABCA1. The Journal of biological chemistry, 277 42, 39477-84Riddle, Tara M; Schildmeyer, Nicholas M; Phan, Cam; Fichtenbaum, Carl J; Hui, David Y 2002. The HIV protease inhibitor ritonavir increases lipoprotein production and has no effect on lipoprotein clearance in mice. Journal of lipid research, 43 9, 1458-63Swertfeger, Debi K; Bu, Guojun; Hui, David Y 2002. Low density lipoprotein receptor-related protein mediates apolipoprotein E inhibition of smooth muscle cell migration. The Journal of biological chemistry, 277 6, 4141-6Yao, Lihang; Heubi, James E; Buckley, Donna D; Fierra, Humberto; Setchell, Kenneth D R; Granholm, Norman A; Tso, Patrick; Hui, David Y; Woollett, Laura A 2002. Separation of micelles and vesicles within lumenal aspirates from healthy humans: solubilization of cholesterol after a meal. Journal of lipid research, 43 4, 654-60Zeleny, Michelle; Swertfeger, Debi K; Weisgraber, Karl H; Hui, David Y 2002. Distinct apolipoprotein E isoform preference for inhibition of smooth muscle cell migration and proliferation. Biochemistry, 41 39, 11820-3Zhu, Binghua; Reardon, Catherine A; Getz, Godfrey S; Hui, David Y 2002. Both apolipoprotein E and immune deficiency exacerbate neointimal hyperplasia after vascular injury in mice. Arteriosclerosis, thrombosis, and vascular biology, 22 3, 450-5Cai, S F; Kirby, R J; Howles, P N; Hui, D Y 2001. Differentiation-dependent expression and localization of the class B type I scavenger receptor in intestine. Journal of lipid research, 42 6, 902-9Du, H; Heur, M; Duanmu, M; Grabowski, G A; Hui, D Y; Witte, D P; Mishra, J 2001. Lysosomal acid lipase-deficient mice: depletion of white and brown fat, severe hepatosplenomegaly, and shortened life span. Journal of lipid research, 42 4, 489-500Richmond, B L; Boileau, A C; Zheng, S; Huggins, K W; Granholm, N A; Tso, P; Hui, D Y 2001. Compensatory phospholipid digestion is required for cholesterol absorption in pancreatic phospholipase A(2)-deficient mice. Gastroenterology, 120 5, 1193-202Riddle, T M; Kuhel, D G; Woollett, L A; Fichtenbaum, C J; Hui, D Y 2001. HIV protease inhibitor induces fatty acid and sterol biosynthesis in liver and adipose tissues due to the accumulation of activated sterol regulatory element-binding proteins in the nucleus. The Journal of biological chemistry, 276 40, 37514-9Riddle, T M; Kuhel, D G; Woollett, L A; Fichtenbaum, C J; Hui, D Y 2001. HIV protease inhibitor induces fatty acid and sterol biosynthesis in liver and adipose tissues due to the accumulation of activated sterol regulatory element-binding proteins in the nucleus. The Journal of biological chemistry, 276 40, 37514-9Swertfeger, D K; Hui, D Y 2001. Apolipoprotein E receptor binding versus heparan sulfate proteoglycan binding in its regulation of smooth muscle cell migration and proliferation. The Journal of biological chemistry, 276 27, 25043-8Swertfeger, D K; Hui, D Y 2001. Apolipoprotein E: a cholesterol transport protein with lipid transport-independent cell signaling properties. Frontiers in bioscience : a journal and virtual library, 6 , D526-35Zhu, B; Zhao, G; Witte, D P; Hui, D Y; Fagin, J A 2001. Targeted overexpression of IGF-I in smooth muscle cells of transgenic mice enhances neointimal formation through increased proliferation and cell migration after intraarterial injury. Endocrinology, 142 8, 3598-606Bridges, J P; Davis, H W; Damodarasamy, M; Kuroki, Y; Howles, G; Hui, D Y; McCormack, F X 2000. Pulmonary surfactant proteins A and D are potent endogenous inhibitors of lipid peroxidation and oxidative cellular injury. The Journal of biological chemistry, 275 49, 38848-55Ishigami, M; Swertfeger, D K; Hui, M S; Granholm, N A; Hui, D Y 2000. Apolipoprotein E inhibition of vascular smooth muscle cell proliferation but not the inhibition of migration is mediated through activation of inducible nitric oxide synthase. Arteriosclerosis, thrombosis, and vascular biology, 20 4, 1020-6Keelan, M; Hui, D Y; Wild, G; Clandinin, M T; Thomson, A B 2000. Variability of the intestinal uptake of lipids is genetically determined in mice. Lipids, 35 8, 833-7Kuhel, D G; Zheng, S; Tso, P; Hui, D Y 2000. Adenovirus-mediated human pancreatic lipase gene transfer to rat bile: gene therapy of fat malabsorption. American journal of physiology. Gastrointestinal and liver physiology, 279 5, G1031-6Liang, Y; Medhekar, R; Brockman, H L; Quinn, D M; Hui, D Y 2000. Importance of arginines 63 and 423 in modulating the bile salt-dependent and bile salt-independent hydrolytic activities of rat carboxyl ester lipase. The Journal of biological chemistry, 275 31, 24040-6Richmond, B L; Hui, D Y 2000. Molecular structure and tissue-specific expression of the mouse pancreatic phospholipase A(2) gene. Gene, 244 1-2, 65-72Zhu, B; Kuhel, D G; Witte, D P; Hui, D Y 2000. Apolipoprotein E inhibits neointimal hyperplasia after arterial injury in mice. The American journal of pathology, 157 6, 1839-48Howles, P N; Stemmerman, G N; Fenoglio-Preiser, C M; Hui, D Y 1999. Carboxyl ester lipase activity in milk prevents fat-derived intestinal injury in neonatal mice. The American journal of physiology, 277 3 Pt 1, G653-61Young, S C; Hui, D Y 1999. Pancreatic lipase/colipase-mediated triacylglycerol hydrolysis is required for cholesterol transport from lipid emulsions to intestinal cells. The Biochemical journal, 339 ( Pt 3) , 615-20Hui, D Y 1998. Utility and importance of gene knockout animals for nutritional and metabolic research. The Journal of nutrition, 128 11, 2052-7Ishigami, M; Swertfeger, D K; Granholm, N A; Hui, D Y 1998. Apolipoprotein E inhibits platelet-derived growth factor-induced vascular smooth muscle cell migration and proliferation by suppressing signal transduction and preventing cell entry to G1 phase. The Journal of biological chemistry, 273 32, 20156-61Li, F; Hui, D Y 1998. Synthesis and secretion of the pancreatic-type carboxyl ester lipase by human endothelial cells. The Biochemical journal, 329 ( Pt 3) , 675-9Qin, X; Swertfeger, D K; Zheng, S; Hui, D Y; Tso, P 1998. Apolipoprotein AIV: a potent endogenous inhibitor of lipid oxidation. The American journal of physiology, 274 5 Pt 2, H1836-40Carter, C P; Howles, P N; Hui, D Y 1997. Genetic variation in cholesterol absorption efficiency among inbred strains of mice. The Journal of nutrition, 127 7, 1344-8Hornick, C A; Hui, D Y; DeLamatre, J G 1997. A role for retrosomes in intracellular cholesterol transport from endosomes to the plasma membrane. The American journal of physiology, 273 3 Pt 1, C1075-81Hui, D Y 1997. Use of gene knockout mice to establish lipase function. Methods in enzymology, 286 , 67-80Li, F; Hui, D Y 1997. Modified low density lipoprotein enhances the secretion of bile salt-stimulated cholesterol esterase by human monocyte-macrophages. species-specific difference in macrophage cholesteryl ester hydrolase. The Journal of biological chemistry, 272 45, 28666-71Feaster, S R; Lee, K; Baker, N; Hui, D Y; Quinn, D M 1996. Molecular recognition by cholesterol esterase of active site ligands: structure-reactivity effects for inhibition by aryl carbamates and subsequent carbamylenzyme turnover. Biochemistry, 35 51, 16723-34Howles, P N; Carter, C P; Hui, D Y 1996. Dietary free and esterified cholesterol absorption in cholesterol esterase (bile salt-stimulated lipase) gene-targeted mice. The Journal of biological chemistry, 271 12, 7196-202Hui, D Y 1996. Molecular biology of enzymes involved with cholesterol ester hydrolysis in mammalian tissues. Biochimica et biophysica acta, 1303 1, 1-14Li, F; Huang, Y; Hui, D Y 1996. Bile salt stimulated cholesterol esterase increases uptake of high density lipoprotein-associated cholesteryl esters by HepG2 cells. Biochemistry, 35 21, 6657-63Brodt-Eppley, J; Hui, D Y 1995. Calcium mobilization and protein kinase C activation are required for cholecystokinin stimulation of pancreatic cholesterol esterase secretion. The Biochemical journal, 306 ( Pt 2) , 605-8Brodt-Eppley, J; White, P; Jenkins, S; Hui, D Y 1995. Plasma cholesterol esterase level is a determinant for an atherogenic lipoprotein profile in normolipidemic human subjects. Biochimica et biophysica acta, 1272 2, 69-72Myers-Payne, S C; Hui, D Y; Brockman, H L; Schroeder, F 1995. Cholesterol esterase: a cholesterol transfer protein. Biochemistry, 34 12, 3942-7Brodt-Eppley, J; Hui, D Y 1994. Dietary regulation of cholesterol esterase mRNA level in rat pancreas. Journal of lipid research, 35 1, 27-35DiPersio, L P; Carter, C P; Hui, D Y 1994. Exon 11 of the rat cholesterol esterase gene encodes domains important for intracellular processing and bile salt-modulated activity of the protein. Biochemistry, 33 11, 3442-8Huang, Y; Hui, D Y 1994. Increased cholesterol esterase level by cholesterol loading of rat pancreatoma cells. Biochimica et biophysica acta, 1214 3, 317-22Huang, Y; Hui, D Y 1994. Synergistic effects of bombesin and cholecystokinin on cholesterol esterase biosynthesis and secretion by AR42J cells. Archives of biochemistry and biophysics, 310 1, 54-9DiPersio, L P; Hui, D Y 1993. Aspartic acid 320 is required for optimal activity of rat pancreatic cholesterol esterase. The Journal of biological chemistry, 268 1, 300-4Hui, D Y; Hayakawa, K; Oizumi, J 1993. Lipoamidase activity in normal and mutagenized pancreatic cholesterol esterase (bile salt-stimulated lipase). The Biochemical journal, 291 ( Pt 1) , 65-9Warden, C H; Davis, R C; Yoon, M Y; Hui, D Y; Svenson, K; Xia, Y R; Diep, A; He, K Y; Lusis, A J 1993. Chromosomal localization of lipolytic enzymes in the mouse: pancreatic lipase, colipase, hormone-sensitive lipase, hepatic lipase, and carboxyl ester lipase. Journal of lipid research, 34 8, 1451-5DiPersio, L P; Kissel, J A; Hui, D Y 1992. Purification of pancreatic cholesterol esterase expressed in recombinant baculovirus-infected Sf9 cells. Protein expression and purification, 3 2, 114-20DiPersio, L P; Fontaine, R N; Hui, D Y 1991. Site-specific mutagenesis of an essential histidine residue in pancreatic cholesterol esterase. The Journal of biological chemistry, 266 7, 4033-6Fontaine, R N; Carter, C P; Hui, D Y 1991. Structure of the rat pancreatic cholesterol esterase gene. Biochemistry, 30 28, 7008-14Huang, Y; Hui, D Y 1991. Cholesterol esterase biosynthesis in rat pancreatic AR42J cells. Post-transcriptional activation by gastric hormones. The Journal of biological chemistry, 266 11, 6720-5Yamashita, S; Hui, D Y; Wetterau, J R; Sprecher, D L; Harmony, J A; Sakai, N; Matsuzawa, Y; Tarui, S 1991. Characterization of plasma lipoproteins in patients heterozygous for human plasma cholesteryl ester transfer protein (CETP) deficiency: plasma CETP regulates high-density lipoprotein concentration and composition. Metabolism: clinical and experimental, 40 7, 756-63DiPersio, L P; Fontaine, R N; Hui, D Y 1990. Identification of the active site serine in pancreatic cholesterol esterase by chemical modification and site-specific mutagenesis. The Journal of biological chemistry, 265 28, 16801-6Huang, Y; Hui, D Y 1990. Metabolic fate of pancreas-derived cholesterol esterase in intestine: an in vitro study using Caco-2 cells. Journal of lipid research, 31 11, 2029-37Hui, D Y; Kissel, J A 1990. Sequence identity between human pancreatic cholesterol esterase and bile salt-stimulated milk lipase. FEBS letters, 276 1-2, 131-4Yamashita, S; Hui, D Y; Sprecher, D L; Matsuzawa, Y; Sakai, N; Tarui, S; Kaplan, D; Wetterau, J R; Harmony, J A 1990. Total deficiency of plasma cholesteryl ester transfer protein in subjects homozygous and heterozygous for the intron 14 splicing defect. Biochemical and biophysical research communications, 170 3, 1346-51Yamashita, S; Sprecher, D L; Sakai, N; Matsuzawa, Y; Tarui, S; Hui, D Y 1990. Accumulation of apolipoprotein E-rich high density lipoproteins in hyperalphalipoproteinemic human subjects with plasma cholesteryl ester transfer protein deficiency. The Journal of clinical investigation, 86 3, 688-95Boyles, J K; Zoellner, C D; Anderson, L J; Kosik, L M; Pitas, R E; Weisgraber, K H; Hui, D Y; Mahley, R W; Gebicke-Haerter, P J; Ignatius, M J 1989. A role for apolipoprotein E, apolipoprotein A-I, and low density lipoprotein receptors in cholesterol transport during regeneration and remyelination of the rat sciatic nerve. The Journal of clinical investigation, 83 3, 1015-31Camulli, E D; Linke, M J; Brockman, H L; Hui, D Y 1989. Identity of a cytosolic neutral cholesterol esterase in rat liver with the bile salt stimulated cholesterol esterase in pancreas. Biochimica et biophysica acta, 1005 2, 177-82Kissel, J A; Fontaine, R N; Turck, C W; Brockman, H L; Hui, D Y 1989. Molecular cloning and expression of cDNA for rat pancreatic cholesterol esterase. Biochimica et biophysica acta, 1006 2, 227-36Friedman, G; Wernette-Hammond, M E; Hui, D Y; Mahley, R W; Innerarity, T L 1987. Characterization of lipoprotein receptors on rat Fu5AH hepatoma cells. Journal of lipid research, 28 12, 1482-94Hui, D Y; Brecht, W J; Hall, E A; Friedman, G; Innerarity, T L; Mahley, R W 1986. Isolation and characterization of the apolipoprotein E receptor from canine and human liver. The Journal of biological chemistry, 261 9, 4256-67Innerarity, T L; Hui, D Y; Bersot, T P; Mahley, R W 1986. Type III hyperlipoproteinemia: a focus on lipoprotein receptor-apolipoprotein E2 interactions. Advances in experimental medicine and biology, 201 , 273-88Mahley, R W; Innerarity, T L; Hui, D Y; Weisgraber, K H; Pitas, R E 1986. Pathology: plasma cholesterol levels determined by lipoprotein interactions with cell surface receptors. The Western journal of medicine, 145 3, 372Mahley, R W; Innerarity, T L; Weisgraber, K H; Rall, S C; Hui, D Y; Lalazar, A; Boyles, J K; Taylor, J M; Levy-Wilson, B 1986. Cellular and molecular biology of lipoprotein metabolism: characterization of lipoprotein receptor-ligand interactions. Cold Spring Harbor symposia on quantitative biology, 51 Pt 2 , 821-8Vogel, T; Weisgraber, K H; Zeevi, M I; Ben-Artzi, H; Levanon, A Z; Rall, S C; Innerarity, T L; Hui, D Y; Taylor, J M; Kanner, D 1985. Human apolipoprotein E expression in Escherichia coli: structural and functional identity of the bacterially produced protein with plasma apolipoprotein E. Proceedings of the National Academy of Sciences of the United States of America, 82 24, 8696-700Hui, D Y; Innerarity, T L; Mahley, R W 1984. Defective hepatic lipoprotein receptor binding of beta-very low density lipoproteins from type III hyperlipoproteinemic patients. Importance of apolipoprotein E. The Journal of biological chemistry, 259 2, 860-9Hui, D Y; Innerarity, T L; Milne, R W; Marcel, Y L; Mahley, R W 1984. Binding of chylomicron remnants and beta-very low density lipoproteins to hepatic and extrahepatic lipoprotein receptors. A process independent of apolipoprotein B48. The Journal of biological chemistry, 259 24, 15060-8Harmony, J A; Hui, D Y 1981. Inhibition by membrane-bound low-density lipoproteins of the primary inductive events of mitogen-stimulated lymphocyte activation. Cancer research, 41 9 Pt 2, 3799-802Hui, D Y; Innerarity, T L; Mahley, R W 1981. Lipoprotein binding to canine hepatic membranes. Metabolically distinct apo-E and apo-B,E receptors. The Journal of biological chemistry, 256 11, 5646-55Hui, D Y; Noel, J G; Harmony, J A 1981. Binding of plasma low density lipoproteins to erythrocytes. Biochimica et biophysica acta, 664 3, 513-26Innerarity, T L; Kempner, E S; Hui, D Y; Mahley, R W 1981. Functional unit of the low density lipoprotein receptor of fibroblasts: a 100,000-dalton structure with multiple binding sites. Proceedings of the National Academy of Sciences of the United States of America, 78 7, 4378-82Mahley, R W; Hui, D Y; Innerarity, T L; Weisgraber, K H 1981. Two independent lipoprotein receptors on hepatic membranes of dog, swine, and man. Apo-B,E and apo-E receptors. The Journal of clinical investigation, 68 5, 1197-206Noel, J G; Hui, D Y; Blankenship, D T; Harmony, J A 1981. Reduced immunoregulatory potency of low density lipoproteins with selectively modified arginine and lysine residues of apolipoprotein B. Biochimica et biophysica acta, 665 3, 519-30Hui, D Y; Harmony, J A 1980. Phosphatidylinositol turnover in mitogen-activated lymphocytes. Suppression by low-density lipoproteins. The Biochemical journal, 192 1, 91-8Hui, D Y; Harmony, J A 1980. Inhibition of Ca2+ accumulation in mitogen-activated lymphocytes: role of membrane-bound plasma lipoproteins. Proceedings of the National Academy of Sciences of the United States of America, 77 8, 4764-8Hui, D Y; Harmony, J A 1980. Inhibition by low density lipoproteins of mitogen-stimulated cyclic nucleotide production by lymphocytes. The Journal of biological chemistry, 255 4, 1413-9Hui, D Y; Harmony, J A; Innerarity, T L; Mahley, R W 1980. Immunoregulatory plasma lipoproteins. Role of apoprotein E and apoprotein B. The Journal of biological chemistry, 255 24, 11775-81Hui, D Y; Berebitsky, G L; Harmony, J A 1979. Mitogen-stimulated calcium ion accumulation by lymphocytes. Influence of plasma lipoproteins. The Journal of biological chemistry, 254 11, 4666-73Hui, D Y; Harmony, J A 1979. Interaction of plasma lipoproteins with erythrocytes. II. Modulation of membrane-associated enzymes. Biochimica et biophysica acta, 550 3, 425-34Hui, D Y; Harmony, J A 1979. Interaction of plasma lipoproteins with erythrocytes. I. Alteration of erythrocyte morphology. Biochimica et biophysica acta, 550 3, 407-24Hui, D Y; Harmony, J A 1979. Erythrocyte spectrin alteration induced by low-density lipoprotein. Journal of supramolecular structure, 10 2, 253-63Beisiegel, U; Weber, W; Havinga, J R; Ihrke, G; Hui, D Y; Wernette-Hammond, M E; Turck, C W; Innerarity, T L; Mahley, R W . Apolipoprotein E-binding proteins isolated from dog and human liver. Arteriosclerosis (Dallas, Tex.), 8 3, 288-97Chatterjee, Tapan K; Basford, Joshua E; Yiew, Kan Hui; Stepp, David W; Hui, David Y; Weintraub, Neal L . Role of histone deacetylase 9 in regulating adipogenic differentiation and high fat diet-induced metabolic disease. Adipocyte, 3 4, 333-8Funke, H; Boyles, J; Weisgraber, K H; Ludwig, E H; Hui, D Y; Mahley, R W . Uptake of apolipoprotein E-containing high density lipoproteins by hepatic parenchymal cells. Arteriosclerosis (Dallas, Tex.), 4 5, 452-61Mahley, R W; Hui, D Y; Innerarity, T L; Beisiegel, U . Chylomicron remnant metabolism. Role of hepatic lipoprotein receptors in mediating uptake. Arteriosclerosis (Dallas, Tex.), 9 1 Suppl, I14-8
Research InterestsLipid Metabolism, Atherosclerosis, Diabetes, Obesity, Vascular Biology Our research program focuses on three specific areas relating cholesterol metabolism with individual susceptibility for coronary heart disease. Particular emphasis is placed on the genetic factors that are important for regulation of cholesterol transport and in the maintenance of cell functions in the arterial wall. One area of research uses induced mutant mice (transgenic and knockout mice...
Peer Reviewed Publications Davidson, W S; Inge, T H; Sexmith, H; Heink, A; Elder, D; Hui, D Y; Melchior, J T; Kelesidis, T; Shah, A S 2017. Weight loss surgery in adolescents corrects high-density lipoprotein subspecies and their function. International journal of obesity (2005), 41 1, 83-89Hui, David Y 2017. The good side of cholesterol: a requirement for maintenance of intestinal integrity. Journal of lipid research, 58 10, 1935-1936Konaniah, Eddy S; Kuhel, David G; Basford, Joshua E; Weintraub, Neal L; Hui, David Y 2017. Deficiency of LRP1 in Mature Adipocytes Promotes Diet-Induced Inflammation and Atherosclerosis-Brief Report. Arteriosclerosis, thrombosis, and vascular biology, 37 6, 1046-1049Yiew, Nicole K H; Chatterjee, Tapan K; Tang, Yao Liang; Pellenberg, Rod; Stansfield, Brian K; Bagi, Zsolt; Fulton, David J; Stepp, David W; Chen, Weiqin; Patel, Vijay; Kamath, Vinayak M; Litwin, Sheldon E; Hui, David Y; Rudich, Steven M; Kim, Ha Won; Weintraub, Neal L 2017. A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity. The Journal of biological chemistry, 292 15, 6312-6324Cash, J G; Hui, D Y 2016. Liver-specific overexpression of LPCAT3 reduces postprandial hyperglycemia and improves lipoprotein metabolic profile in mice. Nutrition & diabetes, 6 , e206Goodson, M L; Packard, A E B; Buesing, D R; Maney, M; Myers, B; Fang, Y; Basford, J E; Hui, D Y; Ulrich-Lai, Y M; Herman, J P; Ryan, K K 2016. Chronic stress and Rosiglitazone increase indices of vascular stiffness in male rats. Physiology & behavior, , Hamlin, Allyson Naugle; Basford, Joshua E; Jaeschke, Anja; Hui, David Y 2016. Low density lipoprotein receptor-related protein-1 deficiency exacerbates palmitate-induced steatosis and toxicity in hepatocytes. The Journal of biological chemistry, , Hui, David Y 2016. Intestinal phospholipid and lysophospholipid metabolism in cardiometabolic disease. Current opinion in lipidology, 27 5, 507-12Lee, Wan Ru; Sacharidou, Anastasia; Behling-Kelly, Erica; Oltmann, Sarah C; Zhu, Weifei; Ahmed, Mohamed; Gerard, Robert D; Hui, David Y; Abe, Jun-ichi; Shaul, Philip W; Mineo, Chieko 2015. PDZK1 prevents neointima formation via suppression of breakpoint cluster region kinase in vascular smooth muscle. PloS one, 10 4, e0124494Unruh, Dusten; Srinivasan, Ramprasad; Benson, Tyler; Haigh, Stephen; Coyle, Danielle; Batra, Neil; Keil, Ryan; Sturm, Robert; Blanco, Victor; Palascak, Mary; Franco, Robert S; Tong, Wilson; Chatterjee, Tapan; Hui, David Y; Davidson, W Sean; Aronow, Bruce J; Kalfa, Theodosia; Manka, David; Peairs, Abigail; Blomkalns, Andra; Fulton, David J; Brittain, Julia E; Weintraub, Neal L; Bogdanov, Vladimir Y 2015. Red Blood Cell Dysfunction Induced by High-Fat Diet: Potential Implications for Obesity-Related Atherosclerosis. Circulation, 132 20, 1898-908Yiew, Kan Hui; Chatterjee, Tapan K; Hui, David Y; Weintraub, Neal L 2015. Histone Deacetylases and Cardiometabolic Diseases. Arteriosclerosis, thrombosis, and vascular biology, 35 9, 1914-9Chatterjee, Tapan K; Basford, Joshua E; Knoll, Ellen; Tong, Wilson S; Blanco, Victor; Blomkalns, Andra L; Rudich, Steven; Lentsch, Alex B; Hui, David Y; Weintraub, Neal L 2014. HDAC9 knockout mice are protected from adipose tissue dysfunction and systemic metabolic disease during high-fat feeding. Diabetes, 63 1, 176-87Gadang, Vidya; Konaniah, Eddy; Hui, David Y; Jaeschke, Anja 2014. Mixed-Lineage Kinase 3 Deficiency Promotes Neointima Formation Through Increased Activation of the RhoA Pathway in Vascular Smooth Muscle Cells. Arteriosclerosis, thrombosis, and vascular biology, 34 7, 1429-36Hollie, Norris I; Cash, James G; Matlib, M Abdul; Wortman, Matthew; Basford, Joshua E; Abplanalp, William; Hui, David Y 2014. Micromolar changes in lysophosphatidylcholine concentration cause minor effects on mitochondrial permeability but major alterations in function. Biochimica et biophysica acta, 1841 6, 888-95Hollie, Norris I; Konaniah, Eddy S; Goodin, Colleen; Hui, David Y 2014. Group 1B phospholipase A? inactivation suppresses atherosclerosis and metabolic diseases in LDL receptor-deficient mice. Atherosclerosis, 234 2, 377-80Manka, David; Chatterjee, Tapan K; Stoll, Lynn L; Basford, Joshua E; Konaniah, Eddy S; Srinivasan, Ramprasad; Bogdanov, Vladimir Y; Tang, Yaoliang; Blomkalns, Andra L; Hui, David Y; Weintraub, Neal L 2014. Transplanted Perivascular Adipose Tissue Accelerates Injury-Induced Neointimal Hyperplasia: Role of Monocyte Chemoattractant Protein-1. Arteriosclerosis, thrombosis, and vascular biology, , Manoharan, Palanikumar; Basford, Joshua E; Pilcher-Roberts, Robyn; Neumann, Jonathan; Hui, David Y; Lingrel, Jerry B 2014. Reduced levels of microRNAs miR-124a and miR-150 are associated with increased proinflammatory mediator expression in Krüppel-like factor 2 (KLF2)-deficient macrophages. The Journal of biological chemistry, 289 45, 31638-46Omar, Abdullah; Chatterjee, Tapan K; Tang, Yaoliang; Hui, David Y; Weintraub, Neal L 2014. Proinflammatory Phenotype of Perivascular Adipocytes. Arteriosclerosis, thrombosis, and vascular biology, , Ulrich, Victoria; Konaniah, Eddy S; Herz, Joachim; Gerard, Robert D; Jung, Eunjeong; Yuhanna, Ivan S; Ahmed, Mohamed; Hui, David Y; Mineo, Chieko; Shaul, Philip W 2014. Genetic variants of ApoE and ApoER2 differentially modulate endothelial function. Proceedings of the National Academy of Sciences of the United States of America, 111 37, 13493-8Ulrich, Victoria; Konaniah, Eddy S; Lee, Wan-Ru; Khadka, Sadiksha; Shen, Yu-Min; Herz, Joachim; Salmon, Jane E; Hui, David Y; Shaul, Philip W; Mineo, Chieko 2014. Antiphospholipid antibodies attenuate endothelial repair and promote neointima formation in mice. Journal of the American Heart Association, 3 5, e001369Waltmann, Meaghan D; Basford, Joshua E; Konaniah, Eddy S; Weintraub, Neal L; Hui, David Y 2014. Apolipoprotein E receptor-2 deficiency enhances macrophage susceptibility to lipid accumulation and cell death to augment atherosclerotic plaque progression and necrosis. Biochimica et biophysica acta, , Wang, Fei; Kohan, Alison B; Dong, H Henry; Yang, Qing; Xu, Min; Huesman, Sarah; Lou, Danwen; Hui, David Y; Tso, Patrick 2014. Overexpression of apolipoprotein C-III decreases secretion of dietary triglyceride into lymph. Physiological reports, 2 3, e00247Basford, Joshua E; Koch, Sheryl; Anjak, Ahmad; Singh, Vivek P; Krause, Eric G; Robbins, Nathan; Weintraub, Neal L; Hui, David Y; Rubinstein, Jack 2013. Smooth muscle LDL receptor-related protein-1 deletion induces aortic insufficiency and promotes vascular cardiomyopathy in mice. PloS one, 8 11, e82026Chatterjee, Tapan K; Aronow, Bruce J; Tong, Wilson S; Manka, David; Tang, Yaoliang; Bogdanov, Vladimir Y; Unruh, Dusten; Blomkalns, Andra L; Piegore, Mark G; Weintraub, Daniel S; Rudich, Steven M; Kuhel, David G; Hui, David Y; Weintraub, Neal L 2013. Human coronary artery perivascular adipocytes overexpress genes responsible for regulating vascular morphology, inflammation, and hemostasis. Physiological genomics, 45 16, 697-709Gadang, Vidya; Kohli, Rohit; Myronovych, Andriy; Hui, David Y; Perez-Tilve, Diego; Jaeschke, Anja 2013. MLK3 promotes metabolic dysfunction induced by saturated fatty acid-enriched diet. American journal of physiology. Endocrinology and metabolism, 305 4, E549-56Kuhel, David G; Konaniah, Eddy S; Basford, Joshua E; McVey, Courtney; Goodin, Colleen T; Chatterjee, Tapan K; Weintraub, Neal L; Hui, David Y 2013. Apolipoprotein E2 accentuates postprandial inflammation and diet-induced obesity to promote hyperinsulinemia in mice. Diabetes, 62 2, 382-91Shen, Ling; Xiong, Ye; Wang, David Q-H; Howles, Philip; Basford, Joshua E; Wang, Jiang; Xiong, Yu Qing; Hui, David Y; Woods, Stephen C; Liu, Min 2013. Ginsenoside Rb1 reduces fatty liver by activating AMP-activated protein kinase in obese rats. Journal of lipid research, 54 5, 1430-8Wang, Daren; El-Amouri, Salim S; Dai, Mei; Kuan, Chia-Yi; Hui, David Y; Brady, Roscoe O; Pan, Dao 2013. Engineering a lysosomal enzyme with a derivative of receptor-binding domain of apoE enables delivery across the blood-brain barrier. Proceedings of the National Academy of Sciences of the United States of America, 110 8, 2999-3004Cash, James G; Kuhel, David G; Basford, Joshua E; Jaeschke, Anja; Chatterjee, Tapan K; Weintraub, Neal L; Hui, David Y 2012. Apolipoprotein E4 impairs macrophage efferocytosis and potentiates apoptosis by accelerating endoplasmic reticulum stress. The Journal of biological chemistry, 287 33, 27876-84Castañeda, Tamara R; Abplanalp, William; Um, Sung Hee; Pfluger, Paul T; Schrott, Brigitte; Brown, Kimberly; Grant, Erin; Carnevalli, Larissa; Benoit, Stephen C; Morgan, Donald A; Gilham, Dean; Hui, David Y; Rahmouni, Kamal; Thomas, George; Kozma, Sara C; Clegg, Deborah J; Tschöp, Matthias H 2012. Metabolic control by S6 kinases depends on dietary lipids. PloS one, 7 3, e32631Godby, Richard C; Van Den Berg, Yascha W; Srinivasan, Ramprasad; Sturm, Robert; Hui, David Y; Konieczny, Stephen F; Aronow, Bruce J; Ozhegov, Evgeny; Ruf, Wolfram; Versteeg, Henri H; Bogdanov, Vladimir Y 2012. Nonproteolytic properties of murine alternatively spliced tissue factor: implications for integrin-mediated signaling in murine models. Molecular medicine (Cambridge, Mass.), 18 , 771-9Howles, Philip N; Hui, David Y 2012. Physiological role of hepatic NPC1L1 in human cholesterol and lipoprotein metabolism: new perspectives and open questions. Journal of lipid research, 53 11, 2253-5Hui, David Y 2012. Phospholipase A(2) enzymes in metabolic and cardiovascular diseases. Current opinion in lipidology, 23 3, 235-40Lingrel, Jerry B; Pilcher-Roberts, Robyn; Basford, Joshua E; Manoharan, Palanikumar; Neumann, Jon; Konaniah, Eddy S; Srinivasan, Ramprasad; Bogdanov, Vladimir Y; Hui, David Y 2012. Myeloid-specific Krüppel-like factor 2 inactivation increases macrophage and neutrophil adhesion and promotes atherosclerosis. Circulation research, 110 10, 1294-302Liu, Min; Kuhel, David G; Shen, Ling; Hui, David Y; Woods, Stephen C 2012. Apolipoprotein E does not cross the blood-cerebrospinal fluid barrier, as revealed by an improved technique for sampling CSF from mice. American journal of physiology. Regulatory, integrative and comparative physiology, 303 9, R903-8Adams, Michelle R; Konaniah, Eddy; Cash, James G; Hui, David Y 2011. 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