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Photo of  Iain L. Cartwright, PhD

Iain L. Cartwright, PhD

Associate Professor-Emeritus

Associate Professor of Molecular Genetics and Associate Dean of Graduate Education, College of Medicine

Molecular & Cellular Biosciences | College of Medicine

  • Senior Research Associate: Washington University
  • Postdoctoral Fellowship: Harvard University
  • Doctoral Degree: University of Warwick (Biological Sciences)
  • Master's Degree: Oxford University (Chemistry)
  • Master's Degree: University of Warwick (Molecular Enzymology)
  • Bachelor's Degree: Oxford University (Chemistry)
Contact Information
Research Interests

Research in the Cartwright laboratory addresses important questions related to mechanism in the interaction of arsenic with biological tissues by bringing new ideas, new approaches and new models to this field of toxicological research.  We have chosen to innovate by exploiting a genetically highly amenable, but non-traditional, model organism (i.e., Drosophila) to help shed new light on an important field of investigation, given our contemporary appreciation of the pathological consequences...

Peer Reviewed Publications

Muñiz Ortiz, Jorge G; Shang, Junjun; Catron, Brittany; Landero, Julio; Caruso, Joseph A; Cartwright, Iain L 2011. A transgenic Drosophila model for arsenic methylation suggests a metabolic rationale for differential dose-dependent toxicity endpoints. Toxicological sciences : an official journal of the Society of Toxicology, 121 2, 303-11

States, J Christopher; Barchowsky, Aaron; Cartwright, Iain L; Reichard, John F; Futscher, Bernard W; Lantz, R Clark 2011. Arsenic toxicology: translating between experimental models and human pathology. Environmental health perspectives, 119 10, 1356-63

Ortiz, Jorge G Muñiz; Opoka, Robert; Kane, Daniel; Cartwright, Iain L 2009. Investigating arsenic susceptibility from a genetic perspective in Drosophila reveals a key role for glutathione synthetase. Toxicological sciences : an official journal of the Society of Toxicology, 107 2, 416-26

Polak, Michal; Kroeger, David E; Cartwright, Iain L; Ponce deLeon, Claudia 2004. Genotype-specific responses of fluctuating asymmetry and of preadult survival to the effects of lead and temperature stress in Drosophila melanogaster. Environmental pollution (Barking, Essex : 1987), 127 1, 145-55

Polak, Michal; Opoka, Robert; Cartwright, Iain L 2002. Response of fluctuating asymmetry to arsenic toxicity: support for the developmental selection hypothesis. Environmental pollution (Barking, Essex : 1987), 118 1, 19-28

Nenoi, M; Ichimura, S; Mita, K; Yukawa, O; Cartwright, I L 2001. Regulation of the catalase gene promoter by Sp1, CCAAT-recognizing factors, and a WT1/Egr-related factor in hydrogen peroxide-resistant HP100 cells. Cancer research, 61 15, 5885-94

Pile, L A; Cartwright, I L 2000. GAGA factor-dependent transcription and establishment of DNase hypersensitivity are independent and unrelated events in vivo. The Journal of biological chemistry, 275 2, 1398-404

Cartwright, I L; Cryderman, D E; Gilmour, D S; Pile, L A; Wallrath, L L; Weber, J A; Elgin, S C 1999. Analysis of Drosophila chromatin structure in vivo. Methods in enzymology, 304 , 462-96

Nenoi, M; Cartwright, I L; Mita, K; Ichimura, S 1996. Comparison of the 5' upstream region of the evolutionarily equivalent polyubiquitin gene of humans and Chinese hamsters. Gene, 179 2, 297-9

Nenoi, M; Mita, K; Ichimura, S; Cartwright, I L; Takahashi, E; Yamauchi, M; Tsuji, H 1996. Heterogeneous structure of the polyubiquitin gene UbC of HeLa S3 cells. Gene, 175 1-2, 179-85

Jupe, E R; Sinden, R R; Cartwright, I L 1995. Specialized chromatin structure domain boundary elements flanking a Drosophila heat shock gene locus are under torsional strain in vivo. Biochemistry, 34 8, 2628-33

Rogulski, K R; Cartwright, I L 1995. Multiple interacting elements delineate an ecdysone-dependent regulatory region with secondary responsive character. Journal of molecular biology, 249 2, 298-318

Nenoi, M; Mita, K; Ichimura, S; Cartwright, I L 1994. Novel structure of a Chinese hamster polyubiquitin gene. Biochimica et biophysica acta, 1204 2, 271-8

Noël, P; Cartwright, I L 1994. A Sec62p-related component of the secretory protein translocon from Drosophila displays developmentally complex behavior. The EMBO journal, 13 22, 5253-61

Jupe, E R; Sinden, R R; Cartwright, I L 1993. Stably maintained microdomain of localized unrestrained supercoiling at a Drosophila heat shock gene locus. The EMBO journal, 12 3, 1067-75

Cartwright, I L; Kelly, S E 1991. Probing the nature of chromosomal DNA-protein contacts by in vivo footprinting. BioTechniques, 11 2, 188-90, 192-4, 196 p

Cartwright, I L; Elgin, S C 1989. Nonenzymatic cleavage of chromatin. Methods in enzymology, 170 , 359-69

Kelly, S E; Cartwright, I L 1989. Perturbation of chromatin architecture on ecdysterone induction of Drosophila melanogaster small heat shock protein genes. Molecular and cellular biology, 9 1, 332-5

Cartwright, I L 1987. Developmental switch in chromatin structure associated with alternate promoter usage in the Drosophila melanogaster alcohol dehydrogenase gene. The EMBO journal, 6 10, 3097-101

Cartwright, I L; Elgin, S C 1986. Nucleosomal instability and induction of new upstream protein-DNA associations accompany activation of four small heat shock protein genes in Drosophila melanogaster. Molecular and cellular biology, 6 3, 779-91

Eissenberg, J C; Cartwright, I L; Thomas, G H; Elgin, S C 1985. Selected topics in chromatin structure. Annual review of genetics, 19 , 485-536

Cartwright, I L; Elgin, S C 1984. Chemical footprinting of 5S RNA chromatin in embryos of Drosophila melanogaster. The EMBO journal, 3 13, 3101-8

Selleck, S B; Elgin, S C; Cartwright, I L 1984. Supercoil-dependent features of DNA structure at Drosophila locus 67B1. Journal of molecular biology, 178 1, 17-33

Cartwright, I L; Hertzberg, R P; Dervan, P B; Elgin, S C 1983. Cleavage of chromatin with methidiumpropyl-EDTA . iron(II). Proceedings of the National Academy of Sciences of the United States of America, 80 11, 3213-7

Elgin, S C; Cartwright, I L; Fleischmann, G; Lowenhaupt, K; Keene, M A 1983. Cleavage reagents as probes of DNA sequence organization and chromatin structure: Drosophila melanogaster locus 67B1. Cold Spring Harbor symposia on quantitative biology, 47 Pt 1 , 529-38

Lowenhaupt, K; Cartwright, I L; Keene, M A; Zimmerman, J L; Elgin, S C 1983. Chromatin structure in pre- and postblastula embryos of Drosophila. Developmental biology, 99 1, 194-201

Cartwright, I L; Abmayr, S M; Fleischmann, G; Lowenhaupt, K; Elgin, S C; Keene, M A; Howard, G C 1982. Chromatin structure and gene activity: the role of nonhistone chromosomal proteins. CRC critical reviews in biochemistry, 13 1, 1-86

Cartwright, I L; Elgin, S C 1982. Analysis of chromatin structure and DNA sequence organization: use of the 1,10-phenanthroline-cuprous complex. Nucleic acids research, 10 19, 5835-52

Cartwright, I L; Hutchinson, D W 1980. Azidopolynucleotides as photoaffinity reagents. Nucleic acids research, 8 7, 1675-91

Bendall, M R; Cartwright, I L; Clark, P I; Lowe, G; Nurse, D 1977. Inhibition of papain by N-acyl-aminoacetaldehydes and N-acyl-aminopropanones. Evidence for hemithioacetal formation by a cross-saturation technique in nuclear-magnetic resonance spectroscopy. European journal of biochemistry / FEBS, 79 1, 201-9

Cartwright, I L; Hutchinson, D W 1977. A simple, rapid preparation of alpha[32P]-labelled adenosine diphosphate. Nucleic acids research, 4 7, 2507-10

Cartwright, I L; Hutchinson, D W; Armstrong, V W 1976. The reaction between thiols and 8-azidoadenosine derivatives. Nucleic acids research, 3 9, 2331-9