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Photo of  Tom Thompson, PhD

Tom Thompson, PhD

Professor (F3)

COM Mol Gen T Thompson Lab

Education/Credentials
  • B.S.: Northern Illinois University
  • M.S.: Northern Illinois University
  • PhD: University of Wisconsin
  • Post Doc: Nortwestern University
Contact Information
  • Office 2204 Medical Sciences Building
  • 231 Albert Sabin Way
  • Cincinnati, Ohio 45267
  • Office 513-558-4517
  • Fax 513-558-5604
  • Email Tom.Thompson@uc.edu
  • UC Institute Member Seal

Peer Reviewed Publications

Cotton, Thomas R; Fischer, Gerhard; Wang, Xuelu; McCoy, Jason C; Czepnik, Magdalena; Thompson, Thomas B; Hyvönen, Marko 2018. Structure of the human myostatin precursor and determinants of growth factor latency. The EMBO journal, 37 3, 367-383

Walker, Ryan G; McCoy, Jason C; Czepnik, Magdalena; Mills, Melanie J; Hagg, Adam; Walton, Kelly L; Cotton, Thomas R; Hyvönen, Marko; Lee, Richard T; Gregorevic, Paul; Harrison, Craig A; Thompson, Thomas B 2018. Molecular characterization of latent GDF8 reveals mechanisms of activation. Proceedings of the National Academy of Sciences of the United States of America, 115 5, E866-E875

Bylund, Jeffery B; Trinh, Linh T; Awgulewitsch, Cassandra P; Paik, David T; Jetter, Christopher; Jha, Rajneesh; Zhang, Jianhua; Nolan, Kristof; Xu, Chunhui; Thompson, Thomas B; Kamp, Timothy J; Hatzopoulos, Antonis K 2017. Coordinated Proliferation and Differentiation of Human-Induced Pluripotent Stem Cell-Derived Cardiac Progenitor Cells Depend on Bone Morphogenetic Protein Signaling Regulation by GREMLIN 2. Stem cells and development, 26 9, 678-693

Kattamuri, Chandramohan; Nolan, Kristof; Thompson, Thomas B 2017. Analysis and identification of the Grem2 heparin/heparan sulfate-binding motif. The Biochemical journal, 474 7, 1093-1107

Kattamuri, Chandramohan; Nolan, Kristof; Thompson, Thomas B 2017. Correction: Analysis and identification of the Grem2 heparin/heparan sulfate-binding motif. The Biochemical journal, 474 9, 1529

Melchior, John T; Walker, Ryan G; Cooke, Allison L; Morris, Jamie; Castleberry, Mark; Thompson, Thomas B; Jones, Martin K; Song, Hyun D; Rye, Kerry-Anne; Oda, Michael N; Sorci-Thomas, Mary G; Thomas, Michael J; Heinecke, Jay W; Mei, Xiaohu; Atkinson, David; Segrest, Jere P; Lund-Katz, Sissel; Phillips, Michael C; Davidson, W Sean 2017. A consensus model of human apolipoprotein A-I in its monomeric and lipid-free state. Nature structural & molecular biology, 24 12, 1093-1099

Walker, Ryan G; Czepnik, Magdalena; Goebel, Erich J; McCoy, Jason C; Vujic, Ana; Cho, Miook; Oh, Juhyun; Aykul, Senem; Walton, Kelly L; Schang, Gauthier; Bernard, Daniel J; Hinck, Andrew P; Harrison, Craig A; Martinez-Hackert, Erik; Wagers, Amy J; Lee, Richard T; Thompson, Thomas B 2017. Structural basis for potency differences between GDF8 and GDF11. BMC biology, 15 1, 19

Li, Naisi; Yang, Qiyuan; Walker, Ryan G; Thompson, Thomas B; Du, Min; Rodgers, Buel D 2016. Myostatin Attenuation In Vivo Reduces Adiposity, but Activates Adipogenesis. Endocrinology, 157 1, 282-91

Melchior, John T; Walker, Ryan G; Morris, Jamie; Jones, Martin K; Segrest, Jere P; Lima, Diogo B; Carvalho, Paulo C; Gozzo, Fábio C; Castleberry, Mark; Thompson, Thomas B; Davidson, W Sean 2016. An Evaluation of the Crystal Structure of C-terminal Truncated Apolipoprotein A-I in Solution Reveals Structural Dynamics Related to Lipid Binding. The Journal of biological chemistry, 291 10, 5439-51

Nolan, Kristof; Kattamuri, Chandramohan; Rankin, Scott A; Read, Randy J; Zorn, Aaron M; Thompson, Thomas B 2016. Structure of Gremlin-2 in Complex with GDF5 Gives Insight into DAN-Family-Mediated BMP Antagonism. Cell reports, 16 8, 2077-86

Poggioli, Tommaso; Vujic, Ana; Yang, Peiguo; Macias-Trevino, Claudio; Uygur, Aysu; Loffredo, Francesco S; Pancoast, James R; Cho, Miook; Goldstein, Jill; Tandias, Rachel M; Gonzalez, Emilia; Walker, Ryan G; Thompson, Thomas B; Wagers, Amy J; Fong, Yick W; Lee, Richard T 2016. Circulating Growth Differentiation Factor 11/8 Levels Decline With Age. Circulation research, 118 1, 29-37

Sanders, Lehanna N; Schoenhard, John A; Saleh, Mohamed A; Mukherjee, Amrita; Ryzhov, Sergey; McMaster, William G; Nolan, Kristof; Gumina, Richard J; Thompson, Thomas B; Magnuson, Mark A; Harrison, David G; Hatzopoulos, Antonis K 2016. BMP Antagonist Gremlin 2 Limits Inflammation After Myocardial Infarction. Circulation research, 119 3, 434-49

Walker, Ryan G; Poggioli, Tommaso; Katsimpardi, Lida; Buchanan, Sean M; Oh, Juhyun; Wattrus, Sam; Heidecker, Bettina; Fong, Yick W; Rubin, Lee L; Ganz, Peter; Thompson, Thomas B; Wagers, Amy J; Lee, Richard T 2016. Biochemistry and Biology of GDF11 and Myostatin: Similarities, Differences, and Questions for Future Investigation. Circulation research, 118 7, 1125-42

Yilmaz, Atilgan; Kattamuri, Chandramohan; Ozdeslik, Rana N; Schmiedel, Carolyn; Mentzer, Sarah; Schorl, Christoph; Oancea, Elena; Thompson, Thomas B; Fallon, Justin R 2016. MuSK is a BMP co-receptor that shapes BMP responses and calcium signaling in muscle cells. Science signaling, 9 444, ra87

Deng, Xiaodi; Walker, Ryan G; Morris, Jamie; Davidson, W Sean; Thompson, Thomas B 2015. Role of Conserved Proline Residues in Human Apolipoprotein A-IV Structure and Function. The Journal of biological chemistry, 290 17, 10689-702

Nolan, Kristof; Kattamuri, Chandramohan; Luedeke, David M; Angerman, Elizabeth B; Rankin, Scott A; Stevens, Mariana L; Zorn, Aaron M; Thompson, Thomas B 2015. Structure of neuroblastoma suppressor of tumorigenicity 1 (NBL1): insights for the functional variability across bone morphogenetic protein (BMP) antagonists. The Journal of biological chemistry, 290 8, 4759-71

Walker, Ryan G; Angerman, Elizabeth B; Kattamuri, Chandramohan; Lee, Yun-Sil; Lee, Se-Jin; Thompson, Thomas B 2015. Alternative binding modes identified for growth and differentiation factor-associated serum protein (GASP) family antagonism of myostatin. The Journal of biological chemistry, 290 12, 7506-16

Walker, Ryan G; Thompson, Thomas B 2015. Fibronectin-based scaffold domain proteins that bind myostatin: a patent evaluation of WO2014043344. Expert opinion on therapeutic patents, 25 5, 619-24

Nolan, Kristof; Thompson, Thomas B 2014. The DAN family: Modulators of TGF-? signaling and beyond. Protein science : a publication of the Protein Society, ,

Peng, Jia; Wigglesworth, Karen; Rangarajan, Adithya; Eppig, John J; Thompson, Thomas B; Matzuk, Martin M 2014. Amino acid 72 of mouse and human GDF9 mature domain is responsible for altered homodimer bioactivities but has subtle effects on GDF9:BMP15 heterodimer activities. Biology of reproduction, 91 6, 142

Rodgers, Buel D; Wiedeback, Benjamin D; Hoversten, Knut E; Jackson, Melissa F; Walker, Ryan G; Thompson, Thomas B 2014. Myostatin stimulates, not inihibits, C2C12 myoblast proliferation. Endocrinology, 155 3, 670-5

Walker, Ryan G; Deng, Xiaodi; Melchior, John T; Morris, Jamie; Tso, Patrick; Jones, Martin K; Segrest, Jere P; Thompson, Thomas B; Davidson, W Sean 2014. The structure of human apolipoprotein A-IV as revealed by stable isotope-assisted cross-linking, molecular dynamics, and small angle x-ray scattering. The Journal of biological chemistry, 289 9, 5596-608

Cash, Jennifer N; Angerman, Elizabeth B; Kirby, R Jason; Merck, Lisa; Seibel, William L; Wortman, Matthew D; Papoian, Ruben; Nelson, Sandra; Thompson, Thomas B 2013. Development of a Small-Molecule Screening Method for Inhibitors of Cellular Response to Myostatin and Activin A. Journal of biomolecular screening, ,

Deng, Xiaodi; Morris, Jamie; Chaton, Catherine; Schröder, Gunnar F; Davidson, W Sean; Thompson, Thomas B 2013. Small-angle X-ray scattering of apolipoprotein A-IV reveals the importance of its termini for structural stability. The Journal of biological chemistry, 288 7, 4854-66

Nolan, Kristof; Kattamuri, Chandramohan; Luedeke, David M; Deng, Xiaodi; Jagpal, Amrita; Zhang, Fuming; Linhardt, Robert J; Kenny, Alan P; Zorn, Aaron M; Thompson, Thomas B 2013. Structure of Protein Related to Dan and Cerberus: Insights into the Mechanism of Bone Morphogenetic Protein Antagonism. Structure (London, England : 1993), ,

Peng, Jia; Li, Qinglei; Wigglesworth, Karen; Rangarajan, Adithya; Kattamuri, Chandramohan; Peterson, Randall T; Eppig, John J; Thompson, Thomas B; Matzuk, Martin M 2013. Growth differentiation factor 9:bone morphogenetic protein 15 heterodimers are potent regulators of ovarian functions. Proceedings of the National Academy of Sciences of the United States of America, 110 8, E776-85

Peng, Jia; Li, Qinglei; Wigglesworth, Karen; Rangarajan, Adithya; Kattamuri, Chandramohan; Peterson, Randall T; Eppig, John J; Thompson, Thomas B; Matzuk, Martin M 2013. Reply to Mottershead et al.: GDF9:BMP15 heterodimers are potent regulators of ovarian functions. Proceedings of the National Academy of Sciences of the United States of America, 110 25, E2258

Rejon, Carlis A; Hancock, Mark A; Li, Yining N; Thompson, Thomas B; Hébert, Terence E; Bernard, Daniel J 2013. Activins bind and signal via bone morphogenetic protein receptor type II (BMPR2) in immortalized gonadotrope-like cells. Cellular signalling, 25 12, 2717-26

Cash, Jennifer N; Angerman, Elizabeth B; Kattamuri, Chandramohan; Nolan, Kristof; Zhao, Huaying; Sidis, Yisrael; Keutmann, Henry T; Thompson, Thomas B 2012. Structure of myostatin·follistatin-like 3: N-terminal domains of follistatin-type molecules exhibit alternate modes of binding. The Journal of biological chemistry, 287 2, 1043-53

Cash, Jennifer N; Angerman, Elizabeth B; Keutmann, Henry T; Thompson, Thomas B 2012. Characterization of follistatin-type domains and their contribution to myostatin and activin a antagonism. Molecular endocrinology (Baltimore, Md.), 26 7, 1167-78

Deng, Xiaodi; Davidson, W Sean; Thompson, Thomas B 2012. Improving the diffraction of apoA-IV crystals through extreme dehydration. Acta crystallographica. Section F, Structural biology and crystallization communications, 68 Pt 1, 105-10

Deng, Xiaodi; Morris, Jamie; Dressmen, James; Tubb, Matthew R; Tso, Patrick; Jerome, W Gray; Davidson, W Sean; Thompson, Thomas B 2012. The structure of dimeric apolipoprotein A-IV and its mechanism of self-association. Structure (London, England : 1993), 20 5, 767-79

Kattamuri, Chandramohan; Luedeke, David M; Nolan, Kristof; Rankin, Scott A; Greis, Kenneth D; Zorn, Aaron M; Thompson, Thomas B 2012. Members of the DAN Family Are BMP Antagonists That Form Highly Stable Noncovalent Dimers. Journal of molecular biology, 424 5, 313-27

Kattamuri, Chandramohan; Luedeke, David M; Thompson, Thomas B 2012. Expression and purification of recombinant protein related to DAN and cerberus (PRDC). Protein expression and purification, 82 2, 389-95

Zhang, Fuming; Beaudet, Julie M; Luedeke, David M; Walker, Ryan G; Thompson, Thomas B; Linhardt, Robert J 2012. Analysis of the interaction between heparin and follistatin and heparin and follistatin-ligand complexes using surface plasmon resonance. Biochemistry, 51 34, 6797-803

Syed, Khajamohiddin; Kattamuri, Chandramohan; Thompson, Thomas B; Yadav, Jagjit S 2011. Cytochrome b? reductase-cytochrome b? as an active P450 redox enzyme system in Phanerochaete chrysosporium: atypical properties and in vivo evidence of electron transfer capability to CYP63A2. Archives of biochemistry and biophysics, 509 1, 26-32

Cash, Jennifer N; Rejon, Carlis A; McPherron, Alexandra C; Bernard, Daniel J; Thompson, Thomas B 2009. The structure of myostatin:follistatin 288: insights into receptor utilization and heparin binding. The EMBO journal, 28 17, 2662-76

Stamler, Robin; Keutmann, Henry T; Sidis, Yisrael; Kattamuri, Chandramohan; Schneyer, Alan; Thompson, Thomas B 2008. The structure of FSTL3.activin A complex. Differential binding of N-terminal domains influences follistatin-type antagonist specificity. The Journal of biological chemistry, 283 47, 32831-8

Davidson, W Sean; Thompson, Thomas B 2007. The structure of apolipoprotein A-I in high density lipoproteins. The Journal of biological chemistry, 282 31, 22249-53

Cook, Robert W; Thompson, Thomas B; Kurup, Sudhi P; Jardetzky, Theodore S; Woodruff, Teresa K 2005. Structural basis for a functional antagonist in the transforming growth factor beta superfamily. The Journal of biological chemistry, 280 48, 40177-86

Thompson, Thomas B; Lerch, Thomas F; Cook, Robert W; Woodruff, Teresa K; Jardetzky, Theodore S 2005. The structure of the follistatin:activin complex reveals antagonism of both type I and type II receptor binding. Developmental cell, 9 4, 535-43

Yuan, Ping; Thompson, Thomas B; Wurzburg, Beth A; Paterson, Reay G; Lamb, Robert A; Jardetzky, Theodore S 2005. Structural studies of the parainfluenza virus 5 hemagglutinin-neuraminidase tetramer in complex with its receptor, sialyllactose. Structure (London, England : 1993), 13 5, 803-15

Cook, Robert W; Thompson, Thomas B; Jardetzky, Theodore S; Woodruff, Teresa K 2004. Molecular biology of inhibin action. Seminars in reproductive medicine, 22 3, 269-76

Thompson, Thomas B; Cook, Robert W; Chapman, Stacey C; Jardetzky, Theodore S; Woodruff, Teresa K 2004. Beta A versus beta B: is it merely a matter of expression? Molecular and cellular endocrinology, 225 1-2, 9-17

Thompson, Thomas B; Katayama, Kinya; Watanabe, Kenji; Hutchinson, C Richard; Rayment, Ivan 2004. Structural and functional analysis of tetracenomycin F2 cyclase from Streptomyces glaucescens. A type II polyketide cyclase. The Journal of biological chemistry, 279 36, 37956-63

Thompson, Thomas B; Woodruff, Teresa K; Jardetzky, Theodore S 2003. Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF-beta ligand:receptor interactions. The EMBO journal, 22 7, 1555-66

Bauer, C B; Fonseca, M V; Holden, H M; Thoden, J B; Thompson, T B; Escalante-Semerena, J C; Rayment, I 2001. Three-dimensional structure of ATP:corrinoid adenosyltransferase from Salmonella typhimurium in its free state, complexed with MgATP, or complexed with hydroxycobalamin and MgATP. Biochemistry, 40 2, 361-74

Thomas, M G; Thompson, T B; Rayment, I; Escalante-Semerena, J C 2000. Analysis of the adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase (CobU) enzyme of Salmonella typhimurium LT2. Identification of residue His-46 as the site of guanylylation. The Journal of biological chemistry, 275 36, 27576-86

Thompson, T B; Garrett, J B; Taylor, E A; Meganathan, R; Gerlt, J A; Rayment, I 2000. Evolution of enzymatic activity in the enolase superfamily: structure of o-succinylbenzoate synthase from Escherichia coli in complex with Mg2+ and o-succinylbenzoate. Biochemistry, 39 35, 10662-76

Thompson, T B; Thomas, M G; Escalante-Semerena, J C; Rayment, I 1999. Three-dimensional structure of adenosylcobinamide kinase/adenosylcobinamide phosphate guanylyltransferase (CobU) complexed with GMP: evidence for a substrate-induced transferase active site. Biochemistry, 38 40, 12995-3005

Thompson, T B; Thomas, M G; Escalante-Semerena, J C; Rayment, I 1998. Three-dimensional structure of adenosylcobinamide kinase/adenosylcobinamide phosphate guanylyltransferase from Salmonella typhimurium determined to 2.3 A resolution,. Biochemistry, 37 21, 7686-95

Fisher, A J; Thompson, T B; Thoden, J B; Baldwin, T O; Rayment, I 1996. The 1.5-A resolution crystal structure of bacterial luciferase in low salt conditions. The Journal of biological chemistry, 271 36, 21956-68

Thompson, T B; Chou, K C; Zheng, C 1995. Neural network prediction of the HIV-1 protease cleavage sites. Journal of theoretical biology, 177 4, 369-79

Thompson, T B; Chou, K C; Zheng, C 1995. Analysis of the loop-helix interaction in bundle motif protein structures. Journal of protein chemistry, 14 7, 559-66