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Photo of Tom C. Seegar, PhD

Tom C. Seegar, PhD

Assistant Professor

Molecular Genetics, Biochemistry, & Microbiology | College of Medicine

  • Post-Doc: Harvard Medical School
  • Post-Doc: Massachusetts Institute of Technology
  • Ph.D.: Virginia Commonwealth University
Contact Information

Peer Reviewed Publications

Adhikari, Arijit A; Seegar, Tom C M; Ficarro, Scott B; McCurry, Megan D; Ramachandran, Deepti; Yao, Lina; Chaudhari, Snehal N; Ndousse-Fetter, Sula; Banks, Alexander S; Marto, Jarrod A; Blacklow, Stephen C; Devlin, A Sloan 2020. Development of a covalent inhibitor of gut bacterial bile salt hydrolases. Nature chemical biology, 16 3, 318-326

Susa, Katherine J; Seegar, Tom CM; Blacklow, Stephen C; Kruse, Andrew C 2020. A dynamic interaction between CD19 and the tetraspanin CD81 controls B cell co-receptor trafficking. eLife, 9 ,

Jarrett, Sanchez M; Seegar, Tom C M; Andrews, Mark; Adelmant, Guillaume; Marto, Jarrod A; Aster, Jon C; Blacklow, Stephen C 2019. Extension of the Notch intracellular domain ankyrin repeat stack by NRARP promotes feedback inhibition of Notch signaling. Science signaling, 12 606,

Rogers, Julia M; Waters, Colin T; Seegar, Tom C M; Jarrett, Sanchez M; Hallworth, Amelia N; Blacklow, Stephen C; Bulyk, Martha L 2019. Bispecific Forkhead Transcription Factor FoxN3 Recognizes Two Distinct Motifs with Different DNA Shapes. Molecular cell, 74 2, 245-253.e6

Seegar, Tom CM; Blacklow, Stephen C 2019. Domain integration of ADAM family proteins: Emerging themes from structural studies. Experimental biology and medicine (Maywood, N.J.), 244 17, 1510-1519

McMillan, Brian J; Tibbe, Christine; Drabek, Andrew A; Seegar, Tom C M; Blacklow, Stephen C; Klein, Thomas 2017. Structural Basis for Regulation of ESCRT-III Complexes by Lgd. Cell reports, 19 9, 1750-1757

Seegar, Tom C M; Killingsworth, Lauren B; Saha, Nayanendu; Meyer, Peter A; Patra, Dhabaleswar; Zimmerman, Brandon; Janes, Peter W; Rubinstein, Eric; Nikolov, Dimitar B; Skiniotis, Georgios; Kruse, Andrew C; Blacklow, Stephen C 2017. Structural Basis for Regulated Proteolysis by the ?-Secretase ADAM10. Cell, 171 7, 1638-1648.e7

Zimmerman, Brandon; Kelly, Brendan; McMillan, Brian J; Seegar, Tom C M; Dror, Ron O; Kruse, Andrew C; Blacklow, Stephen C 2016. Crystal Structure of a Full-Length Human Tetraspanin Reveals a Cholesterol-Binding Pocket. Cell, 167 4, 1041-1051.e11