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Photo of Igal Ifergan, Ph.D.

Igal Ifergan, Ph.D.

Asst Professor (F3)

COM Molecular Genetics

Education/Credentials
  • B.S.: Université de Montréal
  • M.S.: Université de Montréal
  • Ph.D.: Université de Montréal
Contact Information
  • 2258 Medical Sciences Building
  • Dept. of Molecular Genetics, Biochemistry & Microbiology
  • 231 Albert Sabin Way
  • Cincinnati, Ohio 45267
  • Office 513-558-7146
  • Email igal.ifergan@uc.edu

Peer Reviewed Publications

Cortez, Jessica T; Montauti, Elena; Shifrut, Eric; Gatchalian, Jovylyn; Zhang, Yusi; Shaked, Oren; Xu, Yuanming; Roth, Theodore L; Simeonov, Dimitre R; Zhang, Yana; Chen, Siqi; Li, Zhongmei; Woo, Jonathan M; Ho, Josephine; Vogel, Ian A; Prator, Grace Y; Zhang, Bin; Lee, Youjin; Sun, Zhaolin; Ifergan, Igal; Van Gool, Frédéric; Hargreaves, Diana C; Bluestone, Jeffrey A; Marson, Alexander; Fang, Deyu 2020. CRISPR screen in regulatory T cells reveals modulators of Foxp3. Nature, 582 7812, 416-420

DeBerge, Matthew; Yu, Shuangjin; Dehn, Shirley; Ifergan, Igal; Yeap, Xin Yi; Filipp, Mallory; Becker, Amanda; Luo, Xunrong; Miller, Stephen; Thorp, Edward B 2020. Monocytes prime autoreactive T cells after myocardial infarction. American journal of physiology. Heart and circulatory physiology, 318 1, H116-H123

Park, Seo J; Riccio, Rachel E; Kopp, Sarah J; Ifergan, Igal; Miller, Stephen D; Longnecker, Richard 2020. Herpesvirus Entry Mediator Binding Partners Mediate Immunopathogenesis of Ocular Herpes Simplex Virus 1 Infection. mBio, 11 3,

Sharma, Sripadh; Ifergan, Igal; Kurz, Jonathan E; Linsenmeier, Robert A; Xu, Dan; Cooper, John G; Miller, Stephen D; Kessler, John A 2020. Intravenous Immunomodulatory Nanoparticle Treatment for Traumatic Brain Injury. Annals of neurology, 87 3, 442-455

Podojil, Joseph R; Chiang, Ming-Yi; Ifergan, Igal; Copeland, Ronald; Liu, Linda N; Maloveste, Sebastien; Langermann, Solomon; Liebenson, David; Balabanov, Roumen; Chi, Hongbo; Chen, Lieping; Vignali, Dario A A; Miller, Stephen D 2018. B7-H4 Modulates Regulatory CD4+ T Cell Induction and Function via Ligation of a Semaphorin 3a/Plexin A4/Neuropilin-1 Complex. Journal of immunology (Baltimore, Md. : 1950), 201 3, 897-907

Xu, Dan; Robinson, Andrew P; Ishii, Toshiyuki; Duncan, D'Anne S; Alden, Tord D; Goings, Gwendolyn E; Ifergan, Igal; Podojil, Joseph R; Penaloza-MacMaster, Pablo; Kearney, Jennifer A; Swanson, Geoffrey T; Miller, Stephen D; Koh, Sookyong 2018. Peripherally derived T regulatory and ?? T cells have opposing roles in the pathogenesis of intractable pediatric epilepsy. The Journal of experimental medicine, 215 4, 1169-1186

Edwards, Rebecca G; Kopp, Sarah J; Ifergan, Igal; Shui, Jr-Wen; Kronenberg, Mitchell; Miller, Stephen D; Longnecker, Richard 2017. Murine Corneal Inflammation and Nerve Damage After Infection With HSV-1 Are Promoted by HVEM and Ameliorated by Immune-Modifying Nanoparticle Therapy. Investigative ophthalmology & visual science, 58 1, 282-291

Ifergan, Igal; Davidson, Todd S; Kebir, Hania; Xu, Dan; Palacios-Macapagal, Daphne; Cann, Jennifer; Rodgers, Jane M; Hunter, Zoe N; Pittet, Camille L; Beddow, Sara; Jones, Clare A; Prat, Alexandre; Sleeman, Matthew A; Miller, Stephen D 2017. Targeting the GM-CSF receptor for the treatment of CNS autoimmunity. Journal of autoimmunity, 84 , 1-11

Jeong, Su Ji; Cooper, John G; Ifergan, Igal; McGuire, Tammy L; Xu, Dan; Hunter, Zoe; Sharma, Sripadh; McCarthy, Derrick; Miller, Stephen D; Kessler, John A 2017. Intravenous immune-modifying nanoparticles as a therapy for spinal cord injury in mice. Neurobiology of disease, 108 , 73-82

Plebanek, Michael P; Angeloni, Nicholas L; Vinokour, Elena; Li, Jia; Henkin, Anna; Martinez-Marin, Dalia; Filleur, Stephanie; Bhowmick, Reshma; Henkin, Jack; Miller, Stephen D; Ifergan, Igal; Lee, Yesung; Osman, Iman; Thaxton, C Shad; Volpert, Olga V 2017. Pre-metastatic cancer exosomes induce immune surveillance by patrolling monocytes at the metastatic niche. Nature communications, 8 1, 1319

Ifergan, Igal; Chen, Siqi; Zhang, Bin; Miller, Stephen D 2016. Cutting Edge: MicroRNA-223 Regulates Myeloid Dendritic Cell-Driven Th17 Responses in Experimental Autoimmune Encephalomyelitis. Journal of immunology (Baltimore, Md. : 1950), 196 4, 1455-1459

Smarr, Charles B; Yap, Woon Teck; Neef, Tobias P; Pearson, Ryan M; Hunter, Zoe N; Ifergan, Igal; Getts, Daniel R; Bryce, Paul J; Shea, Lonnie D; Miller, Stephen D 2016. Biodegradable antigen-associated PLG nanoparticles tolerize Th2-mediated allergic airway inflammation pre- and postsensitization. Proceedings of the National Academy of Sciences of the United States of America, 113 18, 5059-64

Terry, Rachael L; Ifergan, Igal; Miller, Stephen D 2016. Experimental Autoimmune Encephalomyelitis in Mice. Methods in molecular biology (Clifton, N.J.), 1304 , 145-60

Larochelle, Catherine; Cayrol, Romain; Kebir, Hania; Alvarez, Jorge Ivan; Lécuyer, Marc-André; Ifergan, Igal; Viel, Émilie; Bourbonnière, Lyne; Beauseigle, Diane; Terouz, Simone; Hachehouche, Lamia; Gendron, Steve; Poirier, Josée; Jobin, Céline; Duquette, Pierre; Flanagan, Ken; Yednock, Ted; Arbour, Nathalie; Prat, Alexandre 2012. Melanoma cell adhesion molecule identifies encephalitogenic T lymphocytes and promotes their recruitment to the central nervous system. Brain : a journal of neurology, 135 Pt 10, 2906-24

Alvarez, Jorge Ivan; Dodelet-Devillers, Aurore; Kebir, Hania; Ifergan, Igal; Fabre, Pierre J; Terouz, Simone; Sabbagh, Mike; Wosik, Karolina; Bourbonnière, Lyne; Bernard, Monique; van Horssen, Jack; de Vries, Helga E; Charron, Frédéric; Prat, Alexandre 2011. The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence. Science (New York, N.Y.), 334 6063, 1727-31

Cayrol, Romain; Haqqani, Arsalan S; Ifergan, Igal; Dodelet-Devillers, Aurore; Prat, Alexandre 2011. Isolation of human brain endothelial cells and characterization of lipid raft-associated proteins by mass spectroscopy. Methods in molecular biology (Clifton, N.J.), 686 , 275-95

Ifergan, Igal; Kebir, Hania; Alvarez, Jorge I; Marceau, Gabriel; Bernard, Monique; Bourbonnière, Lyne; Poirier, Josée; Duquette, Pierre; Talbot, Pierre J; Arbour, Nathalie; Prat, Alexandre 2011. Central nervous system recruitment of effector memory CD8+ T lymphocytes during neuroinflammation is dependent on ?4 integrin. Brain : a journal of neurology, 134 Pt 12, 3560-77

Ifergan, Igal; Kebir, Hania; Terouz, Simone; Alvarez, Jorge I; Lécuyer, Marc-André; Gendron, Steve; Bourbonnière, Lyne; Dunay, Ildiko R; Bouthillier, Alain; Moumdjian, Robert; Fontana, Adriano; Haqqani, Arsalan; Klopstein, Armelle; Prinz, Marco; López-Vales, Rubèn; Birchler, Thomas; Prat, Alexandre 2011. Role of Ninjurin-1 in the migration of myeloid cells to central nervous system inflammatory lesions. Annals of neurology, 70 5, 751-63

Schneider, Raphael; Mohebiany, Alma Nazlie; Ifergan, Igal; Beauseigle, Diane; Duquette, Pierre; Prat, Alexandre; Arbour, Nathalie 2011. B cell-derived IL-15 enhances CD8 T cell cytotoxicity and is increased in multiple sclerosis patients. Journal of immunology (Baltimore, Md. : 1950), 187 8, 4119-28

Kebir, Hania; Ifergan, Igal; Alvarez, Jorge Ivan; Bernard, Monique; Poirier, Josée; Arbour, Nathalie; Duquette, Pierre; Prat, Alexandre 2009. Preferential recruitment of interferon-gamma-expressing TH17 cells in multiple sclerosis. Annals of neurology, 66 3, 390-402

Schulze-Topphoff, Ulf; Prat, Alexandre; Prozorovski, Timour; Siffrin, Volker; Paterka, Magdalena; Herz, Josephine; Bendix, Ivo; Ifergan, Igal; Schadock, Ines; Mori, Marcelo A; Van Horssen, Jack; Schröter, Friederike; Smorodchenko, Alina; Han, May Htwe; Bader, Michael; Steinman, Lawrence; Aktas, Orhan; Zipp, Frauke 2009. Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system. Nature medicine, 15 7, 788-93

Cayrol, Romain; Wosik, Karolina; Berard, Jennifer L; Dodelet-Devillers, Aurore; Ifergan, Igal; Kebir, Hania; Haqqani, Arsalan S; Kreymborg, Katharina; Krug, Sebastian; Moumdjian, Robert; Bouthillier, Alain; Becher, Burkhard; Arbour, Nathalie; David, Samuel; Stanimirovic, Danica; Prat, Alexandre 2008. Activated leukocyte cell adhesion molecule promotes leukocyte trafficking into the central nervous system. Nature immunology, 9 2, 137-45

Ifergan, Igal; Kébir, Hania; Bernard, Monique; Wosik, Karolina; Dodelet-Devillers, Aurore; Cayrol, Romain; Arbour, Nathalie; Prat, Alexandre 2008. The blood-brain barrier induces differentiation of migrating monocytes into Th17-polarizing dendritic cells. Brain : a journal of neurology, 131 Pt 3, 785-99

Niemelä, Jussi; Ifergan, Igal; Yegutkin, Gennady G; Jalkanen, Sirpa; Prat, Alexander; Airas, Laura 2008. IFN-beta regulates CD73 and adenosine expression at the blood-brain barrier. European journal of immunology, 38 10, 2718-26

Kebir, Hania; Kreymborg, Katharina; Ifergan, Igal; Dodelet-Devillers, Aurore; Cayrol, Romain; Bernard, Monique; Giuliani, Fabrizio; Arbour, Nathalie; Becher, Burkhard; Prat, Alexandre 2007. Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation. Nature medicine, 13 10, 1173-5

Ifergan, Igal; Wosik, Karolina; Cayrol, Romain; Kébir, Hania; Auger, Chantale; Bernard, Monique; Bouthillier, Alain; Moumdjian, Robert; Duquette, Pierre; Prat, Alexandre 2006. Statins reduce human blood-brain barrier permeability and restrict leukocyte migration: relevance to multiple sclerosis. Annals of neurology, 60 1, 45-55

Magnus, Tim; Schreiner, Bettina; Korn, Thomas; Jack, Carolyn; Guo, Hong; Antel, Jack; Ifergan, Igal; Chen, Lieping; Bischof, Felix; Bar-Or, Amit; Wiendl, Heinz 2005. Microglial expression of the B7 family member B7 homolog 1 confers strong immune inhibition: implications for immune responses and autoimmunity in the CNS. The Journal of neuroscience : the official journal of the Society for Neuroscience, 25 10, 2537-46

Kim, Ho Jin; Ifergan, Igal; Antel, Jack P; Seguin, Rosanne; Duddy, Martin; Lapierre, Yves; Jalili, Farzaneh; Bar-Or, Amit 2004. Type 2 monocyte and microglia differentiation mediated by glatiramer acetate therapy in patients with multiple sclerosis. Journal of immunology (Baltimore, Md. : 1950), 172 11, 7144-53

Bar-Or, Amit; Nuttall, Robert K; Duddy, Martin; Alter, Andrea; Kim, Ho Jin; Ifergan, Igal; Pennington, Caroline J; Bourgoin, Pierre; Edwards, Dylan R; Yong, V Wee 2003. Analyses of all matrix metalloproteinase members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosis. Brain : a journal of neurology, 126 Pt 12, 2738-49

Ifergan, Igal; Bernard, Nicole F; Bruneau, Julie; Alary, Michel; Tsoukas, Christos M; Roger, Michel 2002. Allele frequency of three functionally active polymorphisms of the MDR-1 gene in high-risk HIV-negative and HIV-positive Caucasians. AIDS (London, England), 16 17, 2340-2