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Photo of Gary Dean, Ph.D.

Gary Dean, Ph.D.

Professor - Emeritus (FC)

COM Molecular Genetics

  • B.A.: U. California @ Santa Cruz
  • PhD: Yale University
Research Interests

My primary objectives are to understand: the biogenesis, structure, and regulation of expression of chromaffin granule membrane proteins, including synaptotagmin; the biogenic amine transporter; the vacuolar ATPase; the physiology and molecular geneti...

Contact Information
  • Dept. Molecular Genetics, Biochemistry & Microbiology
  • 231 Albert Sabin Way
  • Cincinnati, Ohio 45267-0524
  • Office 513-558-0065
  • Fax 513-558-0014
  • Email

Peer Reviewed Publications

Su, Shengchang; Bangar, Hansraj; Saldanha, Roland; Pemberton, Adin; Aronow, Bruce; Dean, Gary E; Lamkin, Thomas J; Hassett, Daniel J 2014. Construction and characterization of stable, constitutively expressed, chromosomal green and red fluorescent transcriptional fusions in the select agents, Bacillus anthracis, Yersinia pestis, Burkholderia mallei, and Burkholderia pseudomallei. MicrobiologyOpen, 3 5, 610-29

Bowling, B.V., C.A. Huether, L. Wang, M.F. Myers, G.C. Markle, G.E. Dean, E.E. Acra, F.P. Wray, G.A. Jacob 2008. Genetic Literacy of Undergraduate Non-Science Majors and the Impact of Introductory Biology and Genetics Courses BioScience, 58 7, 654

Bowling, Bethany Vice; Acra, Erin E; Wang, Lihshing; Myers, Melanie F; Dean, Gary E; Markle, Glenn C; Moskalik, Christine L; Huether, Carl A 2008. Development and evaluation of a genetics literacy assessment instrument for undergraduates. Genetics, 178 1, 15-22

Sartor, Maureen A; Zorn, Aaron M; Schwanekamp, Jennifer A; Halbleib, Danielle; Karyala, Saikumar; Howell, Michael L; Dean, Gary E; Medvedovic, Mario; Tomlinson, Craig R 2006. A new method to remove hybridization bias for interspecies comparison of global gene expression profiles uncovers an association between mRNA sequence divergence and differential gene expression in Xenopus. Nucleic acids research, 34 1, 185-200

Hewitt, Eric W; Tao, Jing-Xian; Strasser, Jane E; Cutler, Daniel F; Dean, Gary E 2002. Synaptotagmin I-DeltaC2B. A novel synaptotagmin isoform with a single C2 domain in the bovine adrenal medulla. Biochimica et biophysica acta, 1561 1, 76-90

Howell, M L; Alsabbagh, E; Ma, J F; Ochsner, U A; Klotz, M G; Beveridge, T J; Blumenthal, K M; Niederhoffer, E C; Morris, R E; Needham, D; Dean, G E; Wani, M A; Hassett, D J 2000. AnkB, a periplasmic ankyrin-like protein in Pseudomonas aeruginosa, is required for optimal catalase B (KatB) activity and resistance to hydrogen peroxide. Journal of bacteriology, 182 16, 4545-56

Pance, A; Morgan, K; Guest, P C; Bowers, K; Dean, G E; Cutler, D F; Jackson, A P 1999. A PC12 variant lacking regulated secretory organelles: aberrant protein targeting and evidence for a factor inhibiting neuroendocrine gene expression. Journal of neurochemistry, 73 1, 21-30

Strasser, J E; Newman, S L; Ciraolo, G M; Morris, R E; Howell, M L; Dean, G E 1999. Regulation of the macrophage vacuolar ATPase and phagosome-lysosome fusion by Histoplasma capsulatum. Journal of immunology (Baltimore, Md. : 1950), 162 10, 6148-54

Weingart, C., Broitman-Maduro, G., Dean, G., Newman, S., Peppler, M., and Weiss, A. 1999. Effect of labeling treatments on phagocytosis of Bordatella pertussis by human neutrophils Infection & Immunity, 67 8, 4264

Zemlan, F P; Rosenberg, W S; Luebbe, P A; Campbell, T A; Dean, G E; Weiner, N E; Cohen, J A; Rudick, R A; Woo, D 1999. Quantification of axonal damage in traumatic brain injury: affinity purification and characterization of cerebrospinal fluid tau proteins. Journal of neurochemistry, 72 2, 741-50

Hassett, D J; Howell, M L; Ochsner, U A; Vasil, M L; Johnson, Z; Dean, G E 1997. An operon containing fumC and sodA encoding fumarase C and manganese superoxide dismutase is controlled by the ferric uptake regulator in Pseudomonas aeruginosa: fur mutants produce elevated alginate levels. Journal of bacteriology, 179 5, 1452-9

Hassett, D J; Howell, M L; Sokol, P A; Vasil, M L; Dean, G E 1997. Fumarase C activity is elevated in response to iron deprivation and in mucoid, alginate-producing Pseudomonas aeruginosa: cloning and characterization of fumC and purification of native fumC. Journal of bacteriology, 179 5, 1442-51

McLaughlin, L; Zemlan, F P; Dean, G E 1997. Identification of microtubule-associated protein tau isoforms in Alzheimer's paired helical filaments. Brain research bulletin, 43 5, 501-8

Laitala-Leinonen, T; Howell, M L; Dean, G E; Väänänen, H K 1996. Resorption-cycle-dependent polarization of mRNAs for different subunits of V-ATPase in bone-resorbing osteoclasts. Molecular biology of the cell, 7 1, 129-42

Zemlan, F P; Dean, G E 1996. Monoclonal antibody PHF-9 recognizes phosphorylated serine 404 of tau protein and labels paired helical filaments. Journal of neuroscience research, 46 1, 90-7

Pan, Y X; Cheng, J; Xu, J; Rossi, G; Jacobson, E; Ryan-Moro, J; Brooks, A I; Dean, G E; Standifer, K M; Pasternak, G W 1995. Cloning and functional characterization through antisense mapping of a kappa 3-related opioid receptor. Molecular pharmacology, 47 6, 1180-8

Howell, M; Shirvan, A; Stern-Bach, Y; Steiner-Mordoch, S; Strasser, J E; Dean, G E; Schuldiner, S 1994. Cloning and functional expression of a tetrabenazine sensitive vesicular monoamine transporter from bovine chromaffin granules. FEBS letters, 338 1, 16-22

Perler, F B; Davis, E O; Dean, G E; Gimble, F S; Jack, W E; Neff, N; Noren, C J; Thorner, J; Belfort, M 1994. Protein splicing elements: inteins and exteins--a definition of terms and recommended nomenclature. Nucleic acids research, 22 7, 1125-7

Zemlan, F P; Vogelsang, G D; McLaughlin, L; Dean, G E 1994. Alzheimer's paired helical filaments: amyloid precursor protein epitope mapping. Brain research bulletin, 33 4, 387-92

Gu, H H; Xu, J; Gallagher, M; Dean, G E 1993. Peptide splicing in the vacuolar ATPase subunit A from Candida tropicalis. The Journal of biological chemistry, 268 10, 7372-81

Pan, Y X; Gu, H H; Xu, J; Dean, G E 1993. Saccharomyces cerevisiae expression of exogenous vacuolar ATPase subunits B. Biochimica et biophysica acta, 1151 2, 175-85

Schafer, M P; Dean, G E 1993. Cloning and sequence analysis of an H(+)-ATPase-encoding gene from the human dimorphic pathogen Histoplasma capsulatum. Gene, 136 1-2, 295-300

Pan, Y X; Xu, J; Strasser, J E; Howell, M; Dean, G E 1991. Structure and expression of subunit A from the bovine chromaffin cell vacuolar ATPase. FEBS letters, 293 1-2, 89-92

Gu, H H; Gallagher, M J; Rupkey, S; Dean, G E 1990. Gene and derived peptide sequences for C. tropicalis vacuolar ATPase subunit b. Nucleic acids research, 18 24, 7446

Vogelsang, G D; Zemlan, F P; Dean, G E 1990. Purification and solubilization of paired helical filaments from Alzheimer brains. Journal of neurochemistry, 54 1, 148-55

Vogelsang, G D; Zemlan, F P; Dean, G E 1989. Hyperpurification of paired helical filaments reveals elevations in hydroxyproline content and a core structure related peptide fragment. Progress in clinical and biological research, 317 , 791-800

Cuppoletti, J; Strasser, J E; Dean, G E 1988. An immunoreactive 8-azido ATP-labeled protein common to the lysosomal and chromaffin granule membrane. Biochimica et biophysica acta, 946 1, 33-9

Galloway, C J; Dean, G E; Fuchs, R; Mellman, I 1988. Analysis of endosome and lysosome acidification in vitro. Methods in enzymology, 157 , 601-11

Dean, G E; Nelson, P J; Agnew, W S; Rudnick, G 1987. Hydrodynamic properties of the chromaffin granule hydrogen ion pumping adenosinetriphosphatase. Biochemistry, 26 8, 2301-5

Homma, M; Aizawa, S; Dean, G E; Macnab, R M 1987. Identification of the M-ring protein of the flagellar motor of Salmonella typhimurium. Proceedings of the National Academy of Sciences of the United States of America, 84 21, 7483-7

Dean, G E; Nelson, P J; Rudnick, G 1986. Characterization of native and reconstituted hydrogen ion pumping adenosinetriphosphatase of chromaffin granules. Biochemistry, 25 17, 4918-25

Marsh, M; Griffiths, G; Dean, G E; Mellman, I; Helenius, A 1986. Three-dimensional structure of endosomes in BHK-21 cells. Proceedings of the National Academy of Sciences of the United States of America, 83 9, 2899-903

Stader, J; Matsumura, P; Vacante, D; Dean, G E; Macnab, R M 1986. Nucleotide sequence of the Escherichia coli motB gene and site-limited incorporation of its product into the cytoplasmic membrane. Journal of bacteriology, 166 1, 244-52

Aizawa, S I; Dean, G E; Jones, C J; Macnab, R M; Yamaguchi, S 1985. Purification and characterization of the flagellar hook-basal body complex of Salmonella typhimurium. Journal of bacteriology, 161 3, 836-49

Rudnick, G; Humphreys, C J; Dean, G E 1985. Serotonin transport by platelet plasma and granule membranes. Annals of the New York Academy of Sciences, 456 , 277-8

Dean, G E; Fishkes, H; Nelson, P J; Rudnick, G 1984. The hydrogen ion-pumping adenosine triphosphatase of platelet dense granule membrane. Differences from F1F0- and phosphoenzyme-type ATPases. The Journal of biological chemistry, 259 15, 9569-74

Dean, G E; Macnab, R M; Stader, J; Matsumura, P; Burks, C 1984. Gene sequence and predicted amino acid sequence of the motA protein, a membrane-associated protein required for flagellar rotation in Escherichia coli. Journal of bacteriology, 159 3, 991-9

Dean, G E; Aizawa, S I; Macnab, R M 1983. flaAII (motC, cheV) of Salmonella typhimurium is a structural gene involved in energization and switching of the flagellar motor. Journal of bacteriology, 154 1, 84-91

Galloway, C J; Dean, G E; Marsh, M; Rudnick, G; Mellman, I 1983. Acidification of macrophage and fibroblast endocytic vesicles in vitro. Proceedings of the National Academy of Sciences of the United States of America, 80 11, 3334-8

Nelson, P J; Dean, G E; Aronson, P S; Rudnick, G 1983. Hydrogen ion cotransport by the renal brush border glutamate transporter. Biochemistry, 22 23, 5459-63