Feb 25, 2022, 11:39

Pier Paolo Scaglioni, MD, is the Herbert F. Koch Professor of Medicine, and the Division Director for the Division of Hematology/Oncology. Dr. Scaglioni received his medical degree from the University of Modena Medical School, in Italy, in 1989, and completed his Hematology/Oncology fellowship at Memorial Sloan Kettering Cancer Center, New York City, NY, in 2005. Dr. Scaglioni specializes in malignant hematology and is currently the Interim Director of the George L. Strike Bone Marrow Transplant Program at the University of Cincinnati. Dr. Scaglioni also leads a research laboratory which consists of 2 Research Scientists, and a Senior Research Associate. His team is currently studying the effect of KRAS in non-small cell lung cancer. Dr. Scaglioni’s team has identified several cellular networks that are responsible for the survival of KRAS mutant lung cancer. Among these, his research team found that KRAS regulates the metabolism of fatty acid to make the complex lipids necessary for cell proliferation. Furthermore, his team found that KRAS promotes the survival of lung cancer cells by regulating the cellular networks that replace fatty acids that are damaged by free radicals. Because fatty acids have been long studied by metabolic researchers, drugs have been developed for conditions such as obesity and fatty liver disease. A Phase 1 trial using one of those drugs was completed in 2018 to test safety doses. In that trial, the drug appeared to slow tumor growth in 11 of the 17 patients. This drug is now in Phase II trials to measure its effectiveness.

Name : Pier Paolo Scaglioni, MD

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