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Photo of  Kevin Haworth, PhD

Kevin Haworth, PhD

Research Interests

I am interested in understanding the physical mechanisms behind bubble-enhanced ultrasound biotherapies and application of the acoustic signatures of insonified bubbles.  This creates a research program that spans acoustics, signal processing, imagin...

Education/Credentials
  • Doctoral Degree: University of Michigan
  • Master's Degree: University of Michigan
  • Bachelor's Degree: Truman State University
Contact Information
  • UC Institute Member Seal

Peer Reviewed Publications

Bader, Kenneth B; Haworth, Kevin J; Maxwell, Adam D; Holland, Christy K 2018. Post Hoc Analysis of Passive Cavitation Imaging for Classification of Histotripsy-Induced Liquefaction in Vitro. IEEE transactions on medical imaging, 37 1, 106-115

Haworth, Kevin J; Bader, Kenneth B; Rich, Kyle T; Holland, Christy K; Mast, T Douglas 2017. Quantitative Frequency-Domain Passive Cavitation Imaging. IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 64 1, 177-191

Bader, Kenneth B; Haworth, Kevin J; Shekhar, Himanshu; Maxwell, Adam D; Peng, Tao; McPherson, David D; Holland, Christy K 2016. Efficacy of histotripsy combined with rt-PA in vitro. Physics in medicine and biology, 61 14, 5253-74

Haworth, Kevin J; Raymond, Jason L; Radhakrishnan, Kirthi; Moody, Melanie R; Huang, Shao-Ling; Peng, Tao; Shekhar, Himanshu; Klegerman, Melvin E; Kim, Hyunggun; McPherson, David D; Holland, Christy K 2016. Erratum to: "Trans-stent B-mode Ultrasound and Passive Cavitation Imaging" in Ultrasound Med Biol 2016;42(2):518-527. Ultrasound in medicine & biology, 42 5, 1244

Klegerman, Melvin E; Naji, Ali K; Haworth, Kevin J; Zou, Yuejiao; Golunski, Eva; Peng, Tao; Britton, George L; Huang, Shao-Ling; Holland, Christy K; McPherson, David D 2016. Ultrasound-enhanced bevacizumab release from echogenic liposomes for inhibition of atheroma progression. Journal of liposome research, 26 1, 47-56

Mercado, Karla P; Radhakrishnan, Kirthi; Stewart, Kyle; Snider, Lindsay; Ryan, Devin; Haworth, Kevin J 2016. Size-isolation of ultrasound-mediated phase change perfluorocarbon droplets using differential centrifugation. The Journal of the Acoustical Society of America, 139 5, EL142

Radhakrishnan, Kirthi; Holland, Christy K; Haworth, Kevin J 2016. Scavenging dissolved oxygen via acoustic droplet vaporization. Ultrasonics sonochemistry, 31 , 394-403

Sutton, J T; Haworth, K J; Shanmukhappa, S K; Moody, M R; Klegerman, M E; Griffin, J K; Patton, D M; McPherson, D D; Holland, C K 2016. Delivery of bevacizumab to atheromatous porcine carotid tissue using echogenic liposomes. Drug delivery, 23 9, 3594-3605

Haworth, Kevin J; Raymond, Jason L; Radhakrishnan, Kirthi; Moody, Melanie R; Huang, Shao-Ling; Peng, Tao; Shekhar, Himanshu; Klegerman, Melvin E; Kim, Hyunggun; McPherson, David D; Holland, Christy K 2015. Trans-Stent B-Mode Ultrasound And Passive Cavitation Imaging. Ultrasound in medicine & biology, ,

Haworth, Kevin J; Salgaonkar, Vasant A; Corregan, Nicholas M; Holland, Christy K; Mast, T Douglas 2015. Using Passive Cavitation Images to Classify High-Intensity Focused Ultrasound Lesions. Ultrasound in medicine & biology, 41 9, 2420-34

Radhakrishnan, Kirthi; Haworth, Kevin J; Peng, Tao; McPherson, David D; Holland, Christy K 2015. Loss of echogenicity and onset of cavitation from echogenic liposomes: pulse repetition frequency independence. Ultrasound in medicine & biology, 41 1, 208-21

Haworth, Kevin J; Weidner, Christopher R; Abruzzo, Todd A; Shearn, Jason T; Holland, Christy K 2014. Mechanical properties and fibrin characteristics of endovascular coil-clot complexes: relevance to endovascular cerebral aneurysm repair paradigms. Journal of neurointerventional surgery, ,

Raymond, Jason L; Haworth, Kevin J; Bader, Kenneth B; Radhakrishnan, Kirthi; Griffin, Joseph K; Huang, Shao-Ling; McPherson, David D; Holland, Christy K 2014. Broadband Attenuation Measurements of Phospholipid-Shelled Ultrasound Contrast Agents. Ultrasound in medicine & biology, 40 2, 410

Bader, Kenneth B; Radhakrishnan, Kirthi; Haworth, Kevin J; Raymond, Jason L; Huang, Shao-Ling; Peng, Tao; McPherson, David D; Holland, Christy K 2013. Modeling the loss of echogenicity from ultrasound contrast agents. The Journal of the Acoustical Society of America, 134 5, 3977

Koch, Sheryl E; Haworth, Kevin J; Robbins, Nathan; Smith, Margaret A; Lather, Navneet; Anjak, Ahmad; Jiang, Min; Varma, Priyanka; Jones, W Keith; Rubinstein, Jack 2013. Age- and Gender-Related Changes in Ventricular Performance in Wild-Type FVB/N Mice as Evaluated by Conventional and Vector Velocity Echocardiography Imaging: A Retrospective Study. Ultrasound in medicine & biology, 39 11, 2034

Kopechek, Jonathan A; Haworth, Kevin J; Radhakrishnan, Kirthi; Huang, Shao-Ling; Klegerman, Melvin E; McPherson, David D; Holland, Christy K 2013. The impact of bubbles on measurement of drug release from echogenic liposomes. Ultrasonics sonochemistry, 20 4, 1121-30

Littleton, Robert M; Haworth, Kevin J; Tang, Hong; Setchell, Kenneth D R; Nelson, Sandra; Hove, Jay R 2013. Automated in vivo platform for the discovery of functional food treatments of hypercholesterolemia. PloS one, 8 1, e52409

Radhakrishnan, Kirthi; Bader, Kenneth B; Haworth, Kevin J; Kopechek, Jonathan A; Raymond, Jason L; Huang, Shao-Ling; McPherson, David D; Holland, Christy K 2013. Relationship between cavitation and loss of echogenicity from ultrasound contrast agents. Physics in medicine and biology, 58 18, 6541-63

Sutton, Jonathan T; Haworth, Kevin J; Pyne-Geithman, Gail; Holland, Christy K 2013. Ultrasound-mediated drug delivery for cardiovascular disease. Expert opinion on drug delivery, 10 5, 573-92

Haworth, Kevin J; Mast, T Douglas; Radhakrishnan, Kirthi; Burgess, Mark T; Kopechek, Jonathan A; Huang, Shao-Ling; McPherson, David D; Holland, Christy K 2012. Passive imaging with pulsed ultrasound insonations. The Journal of the Acoustical Society of America, 132 1, 544-53

Radhakrishnan, Kirthi; Haworth, Kevin J; Huang, Shao-Ling; Klegerman, Melvin E; McPherson, David D; Holland, Christy K 2012. Stability of echogenic liposomes as a blood pool ultrasound contrast agent in a physiologic flow phantom. Ultrasound in medicine & biology, 38 11, 1970-81

Hitchcock, Kathryn E; Ivancevich, Nikolas M; Haworth, Kevin J; Caudell Stamper, Danielle N; Vela, Deborah C; Sutton, Jonathan T; Pyne-Geithman, Gail J; Holland, Christy K 2011. Ultrasound-enhanced rt-PA thrombolysis in an ex vivo porcine carotid artery model. Ultrasound in medicine & biology, 37 8, 1240-51

Kopechek, Jonathan A; Haworth, Kevin J; Raymond, Jason L; Douglas Mast, T; Perrin, Stephen R; Klegerman, Melvin E; Huang, Shaoling; Porter, Tyrone M; McPherson, David D; Holland, Christy K 2011. Acoustic characterization of echogenic liposomes: frequency-dependent attenuation and backscatter. The Journal of the Acoustical Society of America, 130 5, 3472-81

Zhang, Man; Fabiilli, Mario L; Haworth, Kevin J; Padilla, Frederic; Swanson, Scott D; Kripfgans, Oliver D; Carson, Paul L; Fowlkes, Jeffrey Brian 2011. Acoustic droplet vaporization for enhancement of thermal ablation by high intensity focused ultrasound. Academic radiology, 18 9, 1123-32

Fabiilli, Mario L; Haworth, Kevin J; Sebastian, Ian E; Kripfgans, Oliver D; Carson, Paul L; Fowlkes, J Brian 2010. Delivery of chlorambucil using an acoustically-triggered perfluoropentane emulsion Ultrasound in medicine & biology, 36 8, 1364-75

Zhang, M; Fabiilli, M L; Haworth, K J; Fowlkes, J B; Kripfgans, O D; Roberts, W W; Ives, K A; Carson, P L 2010. Initial investigation of acoustic droplet vaporization for occlusion in canine kidney. Ultrasound in medicine & biology, 36 10, 1691-703

Fabiilli, Mario L; Haworth, Kevin J; Fakhri, Nasir H; Kripfgans, Oliver D; Carson, Paul L; Fowlkes, J Brian 2009. The role of inertial cavitation in acoustic droplet vaporization. IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 56 5, 1006-17

Haworth, Kevin J; Fowlkes, J Brian; Carson, Paul L; Kripfgans, Oliver D 2009. Generalized shot noise model for time-reversal in multiple-scattering media allowing for arbitrary inputs and windowing. The Journal of the Acoustical Society of America, 125 5, 3129-40

Haworth, Kevin J; Fowlkes, J Brian; Carson, Paul L; Kripfgans, Oliver D 2008. Towards aberration correction of transcranial ultrasound using acoustic droplet vaporization. Ultrasound in medicine & biology, 34 3, 435-45

Mercado-Shekhar K.P.;Kleven R.T.;Aponte Rivera H.;Lewis R.;Karani K.B.;Vos H.J.;Abruzzo T.A.;Haworth K.J.;Holland C.K. 12-01-2018. Effect of Clot Stiffness on Recombinant Tissue Plasminogen Activator Lytic Susceptibility in Vitro Ultrasound in Medicine and Biology, 44 12, 2710-2727

Fabiilli M.L.;Sebastian I.E.;Haworth K.J.;Kripfgans O.D.;Carson P.L.;Fowlkes J.B. 12-01-2009. Ultrasonic delivery of a chemotherapeutic agent using Acoustic Droplet Vaporization (ADV) Proceedings - IEEE Ultrasonics Symposium, ,

Fabiilli M.L.;Haworth K.J.;Kripfgans O.D.;Carson P.L.;Fowlkes J.B. 12-01-2008. The role of inertial cavitation in acoustic droplet Vaporization Proceedings - IEEE Ultrasonics Symposium, , 768-771

Haworth K.;Fabiilli M.;Fowlkes J.;Zhang M.;Kripfgans O.;Roberts W.;Carson P. 12-01-2008. Mean echo power as a measure of flow reduction for bubble occlusion therapy Proceedings - IEEE Ultrasonics Symposium, , 776-779

Haworth K.;Kripfgans O. 12-01-2008. Initial growth and coalescence of acoustically vaporized perfluorocarbon microdroplets Proceedings - IEEE Ultrasonics Symposium, , 623-626

Haworth K.;Goldstein B.;Mercado-Shekhar K.;Holland C.;Redington A. 10-31-2017. Dissolved oxygen scavenging by acoustic droplet vaporization using intravascular ultrasound IEEE International Ultrasonics Symposium, IUS, ,

Haworth K.J.;Arunkumar P.;Goldstein B.H.;Su H.;Mercado-Shekhar K.P.;Privitera E.M.;Srivastava R.;Holland C.K.;Redington A.N. 10-31-2017. Dissolved oxygen scavenging by acoustic droplet vaporization using intravascular ultrasound IEEE International Ultrasonics Symposium, IUS, ,

Mercado-Shekhar K.P.;Su H.;Kalaikadal D.S.;Lorenz J.N.;Manglik R.M.;Holland C.K.;Redington A.N.;Haworth K.J. 09-01-2019. Acoustic droplet vaporization-mediated dissolved oxygen scavenging in blood-mimicking fluids, plasma Ultrasonics Sonochemistry, 56 , 114-124

Kripfgans O.D.;Haworth K.J.;Steele D.D.;Swanson S.D. 08-25-2005. Magnetic resonance elastography using time reversed acoustics Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 5746 I, 323-332

Mercado-Shekhar K.P.;Kleven R.;Rivera H.A.;Lewis R.;Karani K.B.;Vos H.J.;Abruzzo T.A.;Haworth K.J.;Holland C.K. 07-01-2019. Erratum to ‘Effect of clot stiffness on recombinant tissue plasminogen activator lytic susceptibilit Ultrasound in Medicine and Biology, 45 7, 1860

Abadi S.H.;Haworth K.J.;Mercado-Shekhar K.P.;Dowling D.R. 07-01-2018. Frequency-sum beamforming for passive cavitation imaging Journal of the Acoustical Society of America, 144 1, 198-209

Haworth K.;Salgaonkar V.;Corregan N.;Holland C.;Mast T. 06-19-2013. Spatial specificity and sensitivity of passive cavitation imaging for monitoring high-intensity focu Proceedings of Meetings on Acoustics, 19 ,

Haworth K.;Raymond J.;Radhakrishnan K.;Moody M.;Huang S.;Peng T.;Shekhar H.;Klegerman M.;Kim H.;McPherson D.;Holland C. 05-01-2016. Erratum to: "Trans-stent B-mode Ultrasound and Passive Cavitation Imaging" in Ultrasound Med Biol 20 Ultrasound in Medicine and Biology, 42 5, 1244

Haworth K.J.;Fowlkes J.B.;Carson P.L.;Kripfgans O.D. 05-01-2010. Erratum: Generalized shot noise model for time-reversal in multiple-scattering media allowing for ar Journal of the Acoustical Society of America, 127 5, 3273

Nguyen K.;Pan H.Y.;Haworth K.;Mahoney E.;Mercado-Shekhar K.P.;Lin C.Y.;Zhang Z.;C. Park Y. 01-01-2019. Multiple-Exposure Drug Release from Stable Nanodroplets by High-Intensity Focused Ultrasound for a P Ultrasound in Medicine and Biology, 45 1, 160-169

Shekhar H.;Palaniappan A.;Peng T.;Lafond M.;Moody M.R.;Haworth K.J.;Huang S.;McPherson D.D.;Holland C.K. 01-01-2019. Characterization and Imaging of Lipid-Shelled Microbubbles for Ultrasound-Triggered Release of Xenon Neurotherapeutics, ,

Schulz M.;Hou G.;Ng V.;Rabiee M.;Cahay M.;Chaudhary S.;Lindley D.;Chauhan D.;Paine M.;Vijayakumar D.;Xu C.;Yin Z.;Haworth K.;Liu Y.;Sundaram M.;Li W.;Mast D.;Shanov V. 01-01-2017. Science to commercialization of carbon nanotube sheet and yarn WSEAS Transactions on Applied and Theoretical Mechanics, 12 , 41-50

Zhang M.;Haworth K.;Swanson S.;Fabiilli M.;Kripfgans O.;Carson P.;Fowlkes J. 01-01-2009. WE?E?304A?05: Acoustic Droplet Vaporization for Enhancement of High Intensity Focused Ultrasound The Medical Physics, 36 6, 2786-2787

Fabiilli M.;Haworth K.;Zhang M.;Fowlkes J.;Kripfgans O.;Roberts W.;Ives K.;Carson P. 01-01-2008. SU?GG?J?196: Vascular Occlusion by Acoustically Vaporized Droplets for Potential Targeted Enhancemen Medical Physics, 35 6, 2724-2725

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