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Photo of  Jack Rubinstein, MD

Jack Rubinstein, MD


Internal Medicine | College of Medicine

  • Fellowship : Michigan State University (Cardiology )
  • Chief Fellow : Michigan State University (Cardiology )
  • Chief Medical Resident : Thomas Jefferson University - Frankford Campus
  • Residency: Albert Einstein Medical Center (Internal Medicine )
  • Research Fellowship: Instituto Nacional de Cardiologia Ignacio Chavez
  • Medical Degree: Universidad Anahuac del Norte - Honors
Board Certifications & Licenses

American Board of Internal Medicine (Cardiovascular Disease) (Certification Date: 2009-11-06) - (Recertification Date: 2019-11-06)


Cardiovascular Disease
Internal Medicine

Contact Information
Research Interests

Advanced Echocardiographic Imaging, Myocardial Energy Utilization.

Clinical Interests


Cardiovascular Disease

Heart Failure


Coronary artery disease

Peripheral Vascular Disease (PVD)

Peer Reviewed Publications

Lam, Chi Keung; Zhao, Wen; Cai, Wenfeng; Vafiadaki, Elizabeth; Florea, Stela M; Ren, Xiaoping; Liu, Yong; Robbins, Nathan; Zhang, Zhiguo; Zhou, Xiaoyang; Jiang, Min; Rubinstein, Jack; Jones, W Keith; Kranias, Evangelia G 2013. Novel role of HAX-1 in ischemic injury protection involvement of heat shock protein 90. Circulation research, 112 1, 79-89

Robbins, Nathan; Koch, Sheryl E; Rubinstein, Jack 2013. Targeting TRPV1 and TRPV2 for potential therapeutic interventions in cardiovascular disease. Translational research : the journal of laboratory and clinical medicine, ,

Yan, Sujuan; Song, Weizhong; Chen, Yamei; Hong, Kui; Rubinstein, Jack; Wang, Hong-Sheng 2013. Low-dose bisphenol A and estrogen increase ventricular arrhythmias following ischemia-reperfusion in female rat hearts. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 56C , 75-80

Chen, Lijuan; Ashraf, Muhammad; Wang, Yingjie; Zhou, Mi; Zhang, John; Qin, Gangjian; Rubinstein, Jack; Weintraub, Neal L; Tang, Yaoliang 2012. The role of notch 1 activation in cardiosphere derived cell differentiation. Stem cells and development, 21 12, 2122-9

Florea, Stela; Anjak, Ahmad; Cai, Wen-Feng; Qian, Jiang; Vafiadaki, Elizabeth; Figueria, Sarah; Haghighi, Kobra; Rubinstein, Jack; Lorenz, John; Kranias, Evangelia G 2012. Constitutive phosphorylation of inhibitor-1 at Ser67 and Thr75 depresses calcium cycling in cardiomyocytes and leads to remodeling upon aging. Basic research in cardiology, 107 5, 279

Haghighi, Kobra; Pritchard, Tracy; Bossuyt, Julie; Waggoner, Jason R; Yuan, Qunying; Fan, Guo-Chang; Osinska, Hanna; Anjak, Ahmad; Rubinstein, Jack; Robbins, Jeffrey; Bers, Donald M; Kranias, Evangelia G 2012. The human phospholamban Arg14-deletion mutant localizes to plasma membrane and interacts with the Na/K-ATPase. Journal of molecular and cellular cardiology, 52 3, 773-82

Koch, Sheryl E; Gao, Xiaoqian; Haar, Lauren; Jiang, Min; Lasko, Valerie M; Robbins, Nathan; Cai, Wenfeng; Brokamp, Cole; Varma, Priyanka; Tranter, Michael; Liu, Yong; Ren, Xiaoping; Lorenz, John N; Wang, Hong-Sheng; Jones, W Keith; Rubinstein, Jack 2012. Probenecid: novel use as a non-injurious positive inotrope acting via cardiac TRPV2 stimulation. Journal of molecular and cellular cardiology, 53 1, 134-44

Koch, Sheryl E; Tranter, Michael; Robbins, Nathan; Luther, Kristin; Singh, Umesh; Jiang, Min; Ren, Xiaoping; Tee, Trisha; Smith, Leah; Varma, Priyanka; Jones, W Keith; Rubinstein, Jack 2012. Probenecid as a Noninjurious Positive Inotrope in an Ischemic Heart Disease Murine Model. Journal of cardiovascular pharmacology and therapeutics, ,

Robbins, Nathan; Koch, Sheryl E; Tranter, Michael; Rubinstein, Jack 2012. The history and future of probenecid. Cardiovascular toxicology, 12 1, 1-9

Gadeela, Nitesh; Rubinstein, Jack; Tamhane, Umesh; Huang, Ruiping; Pathak, Dorothy R; Hosein, Hazel-Ann; Rich, Michael; Dhar, Gaurav; Abela, George S 2011. The impact of circulating cholesterol crystals on vasomotor function implications for no-reflow phenomenon. JACC. Cardiovascular interventions, 4 5, 521-9

Lather, Navneet; Efeovbokhan, Nephertiti; Hakeem, Abdul; Kotaru, Pavan; Abela, George S; Burger, Andrew J; Rubinstein, Jack 2011. Advanced echocardiographic imaging to predict exercise capacity in relatively healthy women. International journal of cardiology, 151 3, 369-71

Patel, Roshan; Janoudi, Abed; Vedre, Ameeth; Aziz, Kusai; Tamhane, Umesh; Rubinstein, Jack; Abela, Oliver G; Berger, Kevin; Abela, George S 2011. Plaque rupture and thrombosis are reduced by lowering cholesterol levels and crystallization with ezetimibe and are correlated with fluorodeoxyglucose positron emission tomography. Arteriosclerosis, thrombosis, and vascular biology, 31 9, 2007-14

Pelosi, Augusta; St John, Linda; Gaymer, Jean; Ferguson, Danielle; Goyal, Sandeep K; Abela, George S; Rubinstein, Jack 2011. Cardiac tissue Doppler and tissue velocity imaging in anesthetized new zealand white rabbits. Journal of the American Association for Laboratory Animal Science : JAALAS, 50 3, 317-21

Huang, Wei; Rubinstein, Jack; Prieto, Alejandro R; Wang, Donna H 2010. Enhanced postmyocardial infarction fibrosis via stimulation of the transforming growth factor-beta-Smad2 signaling pathway: role of transient receptor potential vanilloid type 1 channels. Journal of hypertension, 28 2, 367-76

Huang, Wei; Rubinstein, Jack; Prieto, Alejandro R; Thang, Loc Vinh; Wang, Donna H 2009. Transient receptor potential vanilloid gene deletion exacerbates inflammation and atypical cardiac remodeling after myocardial infarction. Hypertension, 53 2, 243-50

Rubinstein, Jack; Aloka, Feras; Abela, George S 2009. Statin therapy decreases myocardial function as evaluated via strain imaging. Clinical cardiology, 32 12, 684-9

Rubinstein, Jack; Dhoble, Abhijeet; Ferenchick, Gary 2009. Puzzle based teaching versus traditional instruction in electrocardiogram interpretation for medical students--a pilot study. BMC medical education, 9 , 4

Rubinstein, Jack; Pelosi, Augusta; Vedre, Ameeth; Kotaru, Pavan; Abela, George S 2009. Hypercholesterolemia and myocardial function evaluated via tissue doppler imaging. Cardiovascular ultrasound, 7 , 56

Tanaka, Tomoko; Ling, Benjamin C; Rubinstein, Jack H; Crone, Kerry R 2006. Rubinstein-Taybi syndrome in children with tethered spinal cord. Journal of neurosurgery, 105 4 Suppl, 261-4

Rubinstein, Jack 2005. Amiodarone versus sotalol for atrial fibrillation. The New England journal of medicine, 353 6, 627-30; author reply

Wiley, Susan; Swayne, Susan; Rubinstein, Jack H; Lanphear, Nancy E; Stevens, Cathy A 2003. Rubinstein-Taybi syndrome medical guidelines. American journal of medical genetics. Part A, 119A 2, 101-10

Naimi, David R; Munoz, Jose; Rubinstein, Jack; Hostoffer, Robert W . Rubinstein-Taybi syndrome: an immune deficiency as a cause for recurrent infections. Allergy and asthma proceedings : the official journal of regional and state allergy societies, 27 3, 281-4

Rubinstein, Jack; Moghe, Rohit; Mizrachi, Alberto; Dissin, Jonathan . Triptan use preceding life-threatening arrhythmias in charcot-marie-tooth: a case report and review of the literature. Clinical neuropharmacology, 27 1, 14-6