- Fellowship: John Hopkins University
- Fellowship: Johns Hopkins University
- Residency: University of Virginia
- Internship: Mount Sinai School of Medicine
- Bachelor's Degree: Suny Medical Center Stony Brook
- Doctoral Degree: Suny Stony Brook
- Master's Degree: Virginia Commonwealth University
- High School Scholars: New York University School of Medicine
- Fellowship: University of Pennsylvania
American Board of Internal Medicine (Certification Date: 20110822) - (Recertification Date: 20211231)
Clinical Cardiac Electrophysiology
- Medical Sciences Building
- Office 513-558-4721
- Email email@example.com
Atrioventricular Nodal Reentry Tachycardia (AVNRT)
Dr. DeMazumder is a physician-scientist in cardiac electrophysiology (EP). His clinical expertise includes the diagnosis, treatment and prevention of cardiac arrhythmias using cutting-edge approaches, with a particular emphasis on the potentially lethal ventricular arrhythmias and conduction disorders responsible for sudden death. This has remained the focus of Dr. DeMazumder's studies since high school.
More people continue to die suddenly each year (as many as 7 million worldwide) than all other disease-related causes of death combined. The link between the autonomic nervous system, oxidative stress, heart failure and sudden cardiac death is quite strong. The underlying mechanisms remain unclear, hampering development of new, more effective therapies. Using innovative approaches, Dr. DeMazumder's research is aimed at understanding this link in the context of patho/physiological mechanisms, clinically-relevant animal models, novel biosensors, “big data” predictive analytics, and clinical trials.
In this context, Dr. DeMazumder's wet lab employs a variety of in vitro (e.g. patch clamping, fluorescence microscopy, biochemical), ex vivo (e.g., Langendorff-based EP studies), in vivo (e.g., catheter-based EP studies), genetic (e.g., CRISPR/Cas9, in vivo gene transfer), and systemic (e.g., nonlinear dynamics, numerical analysis) approaches to study nerve-myocyte signaling, subcellular oxidative stress, intracellular calcium handling, and ion channel biophysics. His dry lab uses a combination of high performance computing and novel machine and "deep" learning algorithms (some of which were developed by Dr. DeMazumder) to identify "hidden" signatures of brewing critical illness in patients with moderate or advanced disease, as well as in asymptomatic community-based individuals with little or no known disease. These subclinical signatures may be indistinguishable in conventional clinical diagnostics but can be detected using readily available methods in clinical (e.g., ICU, hospital wards, sleep studies) and ambulatory (e.g., implantable devices, "smart" wearables, home) settings.
As a practicing cardiac EP physician, basic scientist and clinical trialist, Dr. DeMazumder’s efforts are aimed at coming “full circle” from bench to the bedside, i.e., by transforming clinical observations into testable research hypotheses, translating basic research findings into medical advances, and designing and evaluating patient treatment protocols in rigorous clinical trials. His curricula vitae are aimed at advancing the quality of life for many, while still being able to care for individuals.
Peer Reviewed Publications
Haghighi, Kobra; Gardner, George; Vafiadaki, Elizabeth; Kumar, Mohit; Green, Lisa C; Ma, Jianyong; Crocker, Jeffrey S; Koch, Sheryl; Arvanitis, Demetrios A; Bidwell, Phillip; Rubinstein, Jack; van de Leur, Rutger; Doevendans, Pieter A; Akar, Fadi G; Tranter, Michael; Wang, Hong-Sheng; Sadayappan, Sakthivel; DeMazumder, Deeptankar; Sanoudou, Despina; Hajjar, Roger J; Stillitano, Francesca; Kranias, Evangelia G 2021. Impaired Right Ventricular Calcium Cycling Is an Early Risk Factor in R14del-Phospholamban Arrhythmias. Journal of personalized medicine, 11 6,
DeMazumder, Deeptankar 2018. The Path of an Early Career Physician and Scientist in Cardiac Electrophysiology. Circulation research, 123 12, 1269-1271
Dey, Swati; DeMazumder, Deeptankar; Sidor, Agnieszka; Foster, D Brian; O'Rourke, Brian 2018. Mitochondrial ROS Drive Sudden Cardiac Death and Chronic Proteome Remodeling in Heart Failure. Circulation research, 123 3, 356-371
Keramati, Ali R; DeMazumder, Deeptankar; Misra, Satish; Chrispin, Jonathan; Assis, Fabrizio R; Raghuram, Chava; Dey, Swati; Calkins, Hugh; Tandri, Harikrishna 2017. Anterior pericardial access to facilitate electrophysiology study and catheter ablation of ventricular arrhythmias: A single tertiary center experience. Journal of cardiovascular electrophysiology, 28 10, 1189-1195