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Photo of  Ricky Y.K. Leung, PhD

Ricky Y.K. Leung, PhD

Research Assistant Professor, Department of Environmental Health, UC College of Medicine

  • PhD: The Chinese University of Hong Kong
  • MPhil: The Chinese University of Hong Kong
  • BSc: The Chinese University of Hong Kong
Research Interests

Dr. Leung’s research has focused upon estrogen signaling in hormone-related cancers. Estrogen receptors in breast cancer are relatively well-studied but their roles in prostate cancer remains controversial. Dr. Leung has discovered several estrogen ...

Contact Information
  • Kettering Laboratory, Room 331
  • 160 Panzeca Way
  • Cincinnati, Ohio 45267
  • Office 513-558-5181
  • Email
  • UC Institute Member Seal

Peer Reviewed Publications

Ho, Shuk-Mei; Cheong, Ana; Lam, Hung-Ming; Hu, Wen-Yang; Shi, Guang-Bin; Zhu, Xuegong; Chen, Jing; Zhang, Xiang; Medvedovic, Mario; Leung, Yuet-Kin; Prins, Gail S 2015. Exposure of Human Prostaspheres to Bisphenol A Epigenetically Regulates SNORD Family Noncoding RNAs via Histone Modification. Endocrinology, 156 11, 3984-95

Panchanathan, Ravichandran; Liu, Hongzhu; Leung, Yuet-Kin; Ho, Shuk-Mei; Choubey, Divaker 2015. Bisphenol A (BPA) stimulates the interferon signaling and activates the inflammasome activity in myeloid cells. Molecular and cellular endocrinology, 415 , 45-55

Zhou, Zilan; Badkas, Apurva; Stevenson, Max; Lee, Joo-Youp; Leung, Yuet-Kin 2015. Herceptin conjugated PLGA-PHis-PEG pH sensitive nanoparticles for targeted and controlled drug delivery. International journal of pharmaceutics, 487 1-2, 81-90

Knower, Kevin C; To, Sarah Q; Leung, Yuet-Kin; Ho, Shuk-Mei; Clyne, Colin D 2014. Endocrine disruption of the epigenome: a breast cancer link. Endocrine-related cancer, 21 2, T33-55

Langevin, Scott M; Pinney, Susan M; Leung, Yuet-Kin; Ho, Shuk-Mei 2014. Does epigenetic drift contribute to age-related increases in breast cancer risk? Epigenomics, 6 4, 367-9

Leung, Yuet-Kin; Chan, Queeny Kwan-Yi; Ng, Chi-Fai; Ma, Fanny Man-Ting; Tse, Ho-Man; To, Ka-Fai; Maranchie, Jodi; Ho, Shuk-Mei; Lau, Kin-Mang 2014. Hsa-miRNA-765 as a key mediator for inhibiting growth, migration and invasion in fulvestrant-treated prostate cancer. PloS one, 9 5, e98037

Yang, Won Seok; Chadalapaka, Gayathri; Cho, Sung-Gook; Lee, Syng-Ook; Jin, Un-Ho; Jutooru, Indira; Choi, Kwangmin; Leung, Yuet-Kin; Ho, Shuk-Mei; Safe, Stephen; Kim, Kyounghyun 2014. The Transcriptional Repressor ZBTB4 Regulates EZH2 Through a MicroRNA-ZBTB4-Specificity Protein Signaling Axis. Neoplasia (New York, N.Y.), 16 12, 1059-69

Brunst, Kelly J; Leung, Yuet-Kin; Ryan, Patrick H; Khurana Hershey, Gurjit K; Levin, Linda; Ji, Hong; Lemasters, Grace K; Ho, Shuk-Mei 2013. Forkhead box protein 3 (FOXP3) hypermethylation is associated with diesel exhaust exposure and risk for childhood asthma. The Journal of allergy and clinical immunology, 131 2, 592-4.e1-3

Lee, Ming-Tsung; Ho, Shuk-Mei; Tarapore, Pheruza; Chung, Irving; Leung, Yuet-Kin 2013. Estrogen receptor beta isoform 5 confers sensitivity of breast cancer cell lines to chemotherapeutic agent-induced apoptosis through interaction with Bcl2L12. Neoplasia (New York, N.Y.), 15 11, 1262-71

Lee, Ming-Tsung; Leung, Yuet-Kin; Chung, Irving; Tarapore, Pheruza; Ho, Shuk-Mei 2013. Estrogen receptor beta (ERbeta1) transactivation is differentially modulated by the transcriptional coregulator Tip60 in a cis-acting element-dependent manner. The Journal of biological chemistry, 288 35, 25038-52

Lee, Ming-Tsung; Ouyang, Bin; Ho, Shuk-Mei; Leung, Yuet-Kin 2013. Differential expression of estrogen receptor beta isoforms in prostate cancer through interplay between transcriptional and translational regulation. Molecular and cellular endocrinology, 376 1-2, 125-35

Ho, Shuk-Mei; Johnson, Abby; Tarapore, Pheruza; Janakiram, Vinothini; Zhang, Xiang; Leung, Yuet-Kin 2012. Environmental epigenetics and its implication on disease risk and health outcomes. ILAR journal / National Research Council, Institute of Laboratory Animal Resources, 53 3-4, 289-305

Lam, Hung-Ming; Suresh Babu, C V; Wang, Jiang; Yuan, Yong; Lam, Ying-Wai; Ho, Shuk-Mei; Leung, Yuet-Kin 2012. Phosphorylation of human estrogen receptor-beta at serine 105 inhibits breast cancer cell migration and invasion. Molecular and cellular endocrinology, 358 1, 27-35

Leung, Yuet-Kin; Lee, Ming-Tsung; Lam, Hung-Ming; Tarapore, Pheruza; Ho, Shuk-Mei 2012. Estrogen receptor-beta and breast cancer: translating biology into clinical practice. Steroids, 77 7, 727-37

Ho, Shuk-Mei; Lee, Ming-Tsung; Lam, Hung-Ming; Leung, Yuet-Kin 2011. Estrogens and prostate cancer: etiology, mediators, prevention, and management. Endocrinology and metabolism clinics of North America, 40 3, 591-614, ix

Leung, Yuet-Kin; Ho, Shuk-Mei 2011. Estrogen receptor beta: switching to a new partner and escaping from estrogen. Science signaling, 4 168, pe19

Ouyang, Bin; Leung, Yuet-Kin; Wang, Vinson; Chung, Ethan; Levin, Linda; Bracken, Bruce; Cheng, Liang; Ho, Shuk-Mei 2011. ?-Methylacyl-CoA racemase spliced variants and their expression in normal and malignant prostate tissues. Urology, 77 1, 249.e1-7

Haynes, Erin N; Heckel, Pamela; Ryan, Patrick; Roda, Sandy; Leung, Yuet-Kin; Sebastian, Kelly; Succop, Paul 2010. Environmental manganese exposure in residents living near a ferromanganese refinery in Southeast Ohio: a pilot study. Neurotoxicology, 31 5, 468-74

Leung, Yuet-Kin; Lam, Hung-Ming; Wu, Shulin; Song, Dan; Levin, Linda; Cheng, Liang; Wu, Chin-Lee; Ho, Shuk-Mei 2010. Estrogen receptor beta2 and beta5 are associated with poor prognosis in prostate cancer, and promote cancer cell migration and invasion. Endocrine-related cancer, 17 3, 675-89

Zhang, Xiang; Wu, Mengchu; Xiao, Hong; Lee, Ming-Tsung; Levin, Linda; Leung, Yuet-Kin; Ho, Shuk-Mei 2010. Methylation of a single intronic CpG mediates expression silencing of the PMP24 gene in prostate cancer. The Prostate, 70 7, 765-76

Hess-Wilson, Janet K; Webb, Siobhan L; Daly, Hannah K; Leung, Yuet-Kin; Boldison, Joanne; Comstock, Clay E S; Sartor, Maureen A; Ho, Shuk-Mei; Knudsen, Karen E 2007. Unique bisphenol A transcriptome in prostate cancer: novel effects on ERbeta expression that correspond to androgen receptor mutation status. Environmental health perspectives, 115 11, 1646-53

Zhang, X; Leung, Y-K; Ho, S-M 2007. AP-2 regulates the transcription of estrogen receptor (ER)-beta by acting through a methylation hotspot of the 0N promoter in prostate cancer cells. Oncogene, 26 52, 7346-54

Ho, Shuk-Mei; Leung, Yuet-Kin; Chung, Irving 2006. Estrogens and antiestrogens as etiological factors and therapeutics for prostate cancer. Annals of the New York Academy of Sciences, 1089 , 177-93

Leung, Yuet-Kin; Gao, Ying; Lau, Kin-Mang; Zhang, Xiang; Ho, Shuk-Mei 2006. ICI 182,780-regulated gene expression in DU145 prostate cancer cells is mediated by estrogen receptor-beta/NFkappaB crosstalk. Neoplasia (New York, N.Y.), 8 4, 242-9

Leung, Yuet-Kin; Ho, John W 2006. Deciphering signaling control by phosphoproteome using mass spectrometry. Protein and peptide letters, 13 5, 467-9

Leung, Yuet-Kin; Mak, Paul; Hassan, Sazzad; Ho, Shuk-Mei 2006. Estrogen receptor (ER)-beta isoforms: a key to understanding ER-beta signaling. Proceedings of the National Academy of Sciences of the United States of America, 103 35, 13162-7

Mak, Paul; Leung, Yuet-Kin; Tang, Wan-Yee; Harwood, Charlotte; Ho, Shuk-Mei 2006. Apigenin suppresses cancer cell growth through ERbeta. Neoplasia (New York, N.Y.), 8 11, 896-904

Ho, John W; Song, Jing Zheng; Leung, Yuet Kin 2005. Activation of p53 by specific agents in potential cancer therapy. Current medicinal chemistry. Anti-cancer agents, 5 2, 131-5

Leung, Yuet-Kin; Lau, Kin-Mang; Mobley, James; Jiang, Zhong; Ho, Shuk-Mei 2005. Overexpression of cytochrome P450 1A1 and its novel spliced variant in ovarian cancer cells: alternative subcellular enzyme compartmentation may contribute to carcinogenesis. Cancer research, 65 9, 3726-34

Leung, Yuet Kin; Wong, Kwong Fai; Lee, Hung Kay; Ho, John W 2004. Cloning and characterization of chironomidae ferrochelatase: copper activation of the purified ferrochelatase. Molecular and cellular biochemistry, 262 1-2, 225-31

Zhu, Xuegong; Leav, Irwin; Leung, Yuet-Kin; Wu, Mengchu; Liu, Qin; Gao, Ying; McNeal, John E; Ho, Shuk-Mei 2004. Dynamic regulation of estrogen receptor-beta expression by DNA methylation during prostate cancer development and metastasis. The American journal of pathology, 164 6, 2003-12

Ho, J.W., Leung, Y.K., and Chan, C.P. 2003. Potential of medicinal herbs in the treatment of liver disorders. Trends in Comparative Biochemistry & Physiology , 9 , 269

Lau, Kin-Mang; Tam, Neville N C; Thompson, Christopher; Cheng, Robert Y S; Leung, Yuet-Kin; Ho, Shuk-Mei 2003. Age-associated changes in histology and gene-expression profile in the rat ventral prostate. Laboratory investigation; a journal of technical methods and pathology, 83 5, 743-57

Leung, Yuet Kin; Ng, Tzi Bun; Ho, John W 2003. Transcriptional regulation of fosl-1 by licorice in rat Clone 9 cells. Life sciences, 73 24, 3109-21

Tam, Neville N C; Gao, Ying; Leung, Yuet-Kin; Ho, Shuk-Mei 2003. Androgenic regulation of oxidative stress in the rat prostate: involvement of NAD(P)H oxidases and antioxidant defense machinery during prostatic involution and regrowth. The American journal of pathology, 163 6, 2513-22

Ho, John W; Leung, Yuet Kin; Chan, Chun Pong 2002. Herbal medicine in the treatment of cancer. Current medicinal chemistry. Anti-cancer agents, 2 2, 209-14

Leung, Yuet Kin; Ho, John W 2002. Induction of UDP-glucuronosyltransferase 1A8 mRNA by 3-methylcholanthene in rat hepatoma cells. Biochemical pharmacology, 63 4, 767-75

Leung, Y K; Ho, J W 2001. Effects of vitamins and common drugs on reduction of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in rat microsomes. Archives of physiology and biochemistry, 109 2, 175-9

Leung, Y K; Ho, J W 2001. Purification and properties of ferrochelatase from Chironomidae larvae. Molecular and cellular biochemistry, 220 1-2, 161-7

Leung, Y K; Ho, J W 1999. Modulation of reduction of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by vitamin C-palmitate. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 124 4, 451-6

Leung, Y K; Ho, J W 1998. Inhibitory effect of nicotine and its metabolites on tolbutamide hydroxylation in rat liver microsomes. Journal of biochemical and biophysical methods, 36 2-3, 87-94

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Department of Environmental & Public Health Sciences
Kettering Lab Building
160 Panzeca Way
Cincinnati, OH 45267-0056
Mail Location: 0056

Phone: 513-558-5701