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Jose A. Cancelas, MD PhD

Department Chair

Education/Credentials
  • MD : Autonomous University of Madrid
  • Specialist: Hospital Ramon y Cajal
  • PhD : University of Alcala de Henares
  • Fellowship: University of Cincinnati
Specialties

Blood Banking and Transfusion Medicine
Hematology

Research Interests

 

  1. Stem Cell Biology & Hematopoietic Microenvironment
  2. Leukemogenesis & Leukemia Therapy
  3. Blood & Cell Therapies
Dr. Cancelas has published over 150 peer-reviewed manuscripts in the areas of hematopoiesis and transfusion/cell therapies. His laboratory is funded by the NIH, US DoD and different private foundations and corporations. Dr. Cancelas  has trained over 40 MD, PhD and MD, PhD professionals. His basic biology laboratory has contribut...

Contact Information

Clinical Interests

Pathology

Peer Reviewed Publications

Adori, Csaba; Daraio, Teresa; Kuiper, Raoul; Barde, Swapnali; Horvathova, Lubica; Yoshitake, Takashi; Ihnatko, Robert; Valladolid-Acebes, Ismael; Vercruysse, Pauline; Wellendorf, Ashley M; Gramignoli, Roberto; Bozoky, Bela; Kehr, Jan; Theodorsson, Elvar; Cancelas, Jose A; Mravec, Boris; Jorns, Carl; Ellis, Ewa; Mulder, Jan; Uhlén, Mathias; Bark, Christina; Hökfelt, Tomas 2021. Disorganization and degeneration of liver sympathetic innervations in nonalcoholic fatty liver disease revealed by 3D imaging. Science advances, 7 30,

Davis, Greg; York, Allen J; Bacon, Willis Clark; Lin, Suh-Chin; McNeal, Monica Malone; Yarawsky, Alexander E; Maciag, Joseph J; Miller, Jeanette L C; Locker, Kathryn C S; Bailey, Michelle; Stone, Rebecca; Hall, Michael; Gonzalez, Judith; Sproles, Alyssa; Woodle, E Steve; Safier, Kristen; Justus, Kristine A; Spearman, Paul; Ware, Russell E; Cancelas, Jose A; Jordan, Michael B; Herr, Andrew B; Hildeman, David A; Molkentin, Jeffery D 2021. Seroprevalence of SARS-CoV-2 infection in Cincinnati Ohio USA from August to December 2020. PloS one, 16 7, e0254667

Fan, Yuping; Teng, Yan; Loison, Fabien; Pang, Aiming; Kasorn, Anongnard; Shao, Xinqi; Zhang, Cunling; Ren, Qian; Yu, Hongbo; Zheng, Yi; Cancelas, Jose A; Manis, John; Chai, Li; Park, Shin-Young; Zhao, Li; Xu, Yuanfu; Feng, Sizhou; Silberstein, Leslie E; Ma, Fengxia; Luo, Hongbo R 2021. Targeting multiple cell death pathways extends the shelf life and preserves the function of human and mouse neutrophils for transfusion. Science translational medicine, 13 604,

Prus, Kristina; Alquist, Caroline R; Cancelas, Jose A; Oh, David 2021. Decrease in serum antibodies to SARS-CoV-2 in convalescent plasma donors over time. Transfusion, 61 2, 651-654

Serrano-Lopez, Juana; Hegde, Shailaja; Kumar, Sachin; Serrano, Josefina; Fang, Jing; Wellendorf, Ashley M; Roche, Paul A; Rangel, Yamileth; Carrington, Leolene J; Geiger, Hartmut; Grimes, H Leighton; Luther, Sanjiv; Maillard, Ivan; Sanchez-Garcia, Joaquin; Starczynowski, Daniel T; Cancelas, Jose A 2021. Inflammation rapidly recruits mammalian GMP and MDP from bone marrow into regional lymphatics. eLife, 10 ,

Althoff, Mark J; Nayak, Ramesh C; Hegde, Shailaja; Wellendorf, Ashley M; Bohan, Breanna; Filippi, Marie-Dominique; Xin, Mei; Lu, Q Richard; Geiger, Hartmut; Zheng, Yi; Diaz-Meco, Maria T; Moscat, Jorge; Cancelas, Jose A 2020. Yap1-Scribble polarization is required for hematopoietic stem cell division and fate. Blood, 136 16, 1824-1836

D?Alessandro, Angelo; Yoshida, Tatsuro; Nestheide, Shawnagay; Nemkov, Travis; Stocker, Sarah; Stefanoni, Davide; Mohmoud, Fatima; Rugg, Neeta; Dunham, Andrew; Cancelas, Jose A 2020. Hypoxic storage of red blood cells improves metabolism and post-transfusion recovery. Transfusion, ,

Gasilina, Anjelika; Premnauth, Gurdat; Gurjar, Purujit; Biesiada, Jacek; Hegde, Shailaja; Milewski, David; Ma, Gang; Kalin, Tanya V; Merino, Edward; Meller, Jarek; Seibel, William; Cancelas, José A; Vinnedge, Lisa Privette; Nassar, Nicolas N 2020. IODVA1, a guanidinobenzimidazole derivative, targets Rac activity and Ras-driven cancer models. PloS one, 15 3, e0229801

Golan, Karin; Singh, Abhishek K; Kollet, Orit; Bertagna, Mayla; Althoff, Mark J; Khatib-Massalha, Eman; Petrovich-Kopitman, Ekaterina; Wellendorf, Ashley M; Massalha, Hassan; Levin-Zaidman, Smadar; Dadosh, Tali; Bohan, Breanna; V Gawali, Mruniya; Dasgupta, Biplab; Lapidot, Tsvee; Cancelas, Jose A 2020. Bone marrow regeneration requires mitochondrial transfer from donor Cx43-expressing hematopoietic progenitors to stroma. Blood, 136 23, 2607-2619

Govindarajah, Vinothini; Lee, Jung-Mi; Solomon, Michael; Goddard, Bryan; Nayak, Ramesh; Nattamai, Kalpana; Geiger, Hartmut; Salomonis, Nathan; Cancelas, Jose A; Reynaud, Damien 2020. FOXO activity adaptation safeguards the hematopoietic stem cell compartment in hyperglycemia. Blood advances, 4 21, 5512-5526

Hegde, Shailaja; Wellendorf, Ashley M; Zheng, Yi; Cancelas, Jose A 2020. Antioxidant prevents clearance of hemostatically competent platelets after long-term cold storage. Transfusion, ,

Kelly, Kathleen; Cancelas, Jose A; Szczepiorkowski, Zbigniew M; Dumont, Deborah F; Rugg, Neeta; Dumont, Larry J 2020. Frozen Platelets-Development and Future Directions. Transfusion medicine reviews, 34 4, 286-293

Nelson, Adam S; Heyenbruch, Daria; Rubinstein, Jeremy D; Sabulski, Anthony; Jodele, Sonata; Thomas, Shawn; Lutzko, Carolyn; Zhu, Xiang; Leemhuis, Thomas; Cancelas, Jose A; Keller, Michael; Bollard, Catherine M; Hanley, Patrick J; Davies, Stella M; Grimley, Michael S 2020. Virus-specific T-cell therapy to treat BK polyomavirus infection in bone marrow and solid organ transplant recipients. Blood advances, 4 22, 5745-5754

Rubinstein, Jeremy D; Zhu, Xiang; Lutzko, Carolyn; Leemhuis, Tom; Cancelas, Jose A; Jodele, Sonata; Bollard, Catherine M; Hanley, Patrick J; Davies, Stella M; Grimley, Michael S; Nelson, Adam S 2020. Complement inhibition does not impair the clinical antiviral capabilities of virus-specific T-cell therapy. Blood advances, 4 14, 3252-3257

Singh, Abhishek K; Cancelas, Jose A 2020. Gap Junctions in the Bone Marrow Lympho-Hematopoietic Stem Cell Niche, Leukemia Progression, and Chemoresistance. International journal of molecular sciences, 21 3,

Yu, Yanan; Choi, Kwangmin; Wu, Jianqiang; Andreassen, Paul R; Dexheimer, Phillip J; Keddache, Mehdi; Brems, Hilde; Spinner, Robert J; Cancelas, Jose A; Martin, Lisa J; Wallace, Margaret R; Legius, Eric; Vogel, Kristine S; Ratner, Nancy 2020. NF1 patient missense variants predict a role for ATM in modifying neurofibroma initiation. Acta neuropathologica, 139 1, 157-174

Boucher, Alexander A; Luchtman-Jones, Lori; Palumbo, Joseph S; Cancelas, Jose A; Abu-El-Haija, Maisam; Jenkins, Todd M; Lin, Tom K; Nathan, Jaimie D 2019. Extreme Thrombocytosis after Pediatric Pancreatectomy with Islet Autotransplantation Is Unique Compared to Other Postsplenectomy States. Journal of pediatric surgery, ,

Cancelas, Jose A 2019. Future of platelet formulations with improved clotting profile: a short review on human safety and efficacy data. Transfusion, 59 S2, 1467-1473

Nayak, R C; Hegde, S; Althoff, M J; Wellendorf, A M; Mohmoud, F; Perentesis, J; Reina-Campos, M; Reynaud, D; Zheng, Y; Diaz-Meco, M T; Moscat, J; Cancelas, J A 2019. The signaling axis atypical protein kinase C ?/?-Satb2 mediates leukemic transformation of B-cell progenitors. Nature communications, 10 1, 46

Nayak, Ramesh C; Cancelas, Jose A 2019. Ubiquitination is not omnipresent in myeloid leukemia. Haematologica, 104 9, 1694-1696

Trump, Lisa R; Nayak, Ramesh C; Singh, Abhishek K; Emberesh, Sana; Wellendorf, Ashley M; Lutzko, Carolyn M; Cancelas, Jose A 2019. Neutrophils Derived from Genetically Modified Human Induced Pluripotent Stem Cells Circulate and Phagocytose Bacteria In Vivo. Stem cells translational medicine, 8 6, 557-567

Fang, Jing; Muto, Tomoya; Kleppe, Maria; Bolanos, Lyndsey C; Hueneman, Kathleen M; Walker, Callum S; Sampson, Leesa; Wellendorf, Ashley M; Chetal, Kashish; Choi, Kwangmin; Salomonis, Nathan; Choi, Yongwon; Zheng, Yi; Cancelas, Jose A; Levine, Ross L; Starczynowski, Daniel T 2018. TRAF6 Mediates Basal Activation of NF-?B Necessary for Hematopoietic Stem Cell Homeostasis. Cell reports, 22 5, 1250-1262

Hegde, Shailaja; Akbar, Huzoor; Zheng, Yi; Cancelas, Jose A 2018. Towards increasing shelf life and haemostatic potency of stored platelet concentrates. Current opinion in hematology, 25 6, 500-508

Lee, Jung-Mi; Govindarajah, Vinothini; Goddard, Bryan; Hinge, Ashwini; Muench, David E; Filippi, Marie-Dominique; Aronow, Bruce; Cancelas, Jose A; Salomonis, Nathan; Grimes, H Leighton; Reynaud, Damien 2018. Obesity alters the long-term fitness of the hematopoietic stem cell compartment through modulation of Gfi1 expression. The Journal of experimental medicine, 215 2, 627-644

Mock, Donald M; Nalbant, Demet; Kyosseva, Svetlana V; Schmidt, Robert L; An, Guohua; Matthews, Nell I; Vlaar, Alexander P J; van Bruggen, Robin; de Korte, Dirk; Strauss, Ronald G; Cancelas, José A; Franco, Robert S; Veng-Pedersen, Peter; Widness, John A 2018. Development, validation, and potential applications of biotinylated red blood cells for posttransfusion kinetics and other physiological studies: evidenced-based analysis and recommendations. Transfusion, 58 8, 2068-2081

Nalbant, Demet; Cancelas, José A; Mock, Donald M; Kyosseva, Svetlana V; Schmidt, Robert L; Cress, Gretchen A; Zimmerman, M Bridget; Strauss, Ronald G; Widness, John A 2018. In premature infants there is no decrease in 24-hour posttransfusion allogeneic red blood cell recovery after 42 days of storage. Transfusion, 58 2, 352-358

Niu, Haixia; Cancelas, Jose A 2018. Twisting the bone marrow stem cell niche. Haematologica, 103 12, 1937-1939

Roy, Swarnava; Rai, Parul; Eiymo Mwa Mpollo, Marthe-Sandrine; Chang, Kyung-Hee; Rizvi, Tilat; Shanmukhappa, Shiva Kumar; VandenHeuvel, Katherine; Aronow, Bruce; Inagami, Tadashi; Cancelas, Jose A; Malik, Punam 2018. Angiotensin receptor signaling in sickle cell anemia has a reno-protective effect on urine concentrating ability but results in sickle glomerulopathy. American journal of hematology, 93 7, E177-E181

Serrano-Lopez, Juana; Nattamai, Kalpana; Pease, Nicholas A; Shephard, Miranda S; Wellendorf, Ashley M; Sertorio, Mathieu; Smith, Eric A; Geiger, Hartmut; Wells, Susanne I; Cancelas, Jose A; Privette Vinnedge, Lisa M 2018. Loss of DEK induces radioresistance of murine restricted hematopoietic progenitors. Experimental hematology, 59 , 40-50.e3

Singh, Abhishek K; Althoff, Mark J; Cancelas, Jose A 2018. Signaling Pathways Regulating Hematopoietic Stem Cell and Progenitor Aging. Current stem cell reports, 4 2, 166-181

Slichter, Sherrill J; Dumont, Larry J; Cancelas, Jose A; Jones, MeLinh; Gernsheimer, Terry B; Szczepiorkowski, Zbigniew M; Dunbar, Nancy M; Prakash, Gautham; Medlin, Stephen; Rugg, Neeta; Kinne, Bridget; Macdonald, Victor W; Housler, Greggory; Valiyaveettil, Manoj; Hmel, Peter; Ransom, Janet H 2018. Safety and efficacy of cryopreserved platelets in bleeding patients with thrombocytopenia. Transfusion, 58 9, 2129-2138

Wang, Jieyu; Hayashi, Yoshihiro; Yokota, Asumi; Xu, Zefeng; Zhang, Yue; Huang, Rui; Yan, Xiaomei; Liu, Hongyun; Ma, Liping; Azam, Mohammad; Bridges, James P; Cancelas, Jose A; Kalfa, Theodosia A; An, Xiuli; Xiao, Zhijian; Huang, Gang 2018. Expansion of EPOR-negative macrophages besides erythroblasts by elevated EPOR signaling in erythrocytosis mouse models. Haematologica, 103 1, 40-50

Zhang, Cuiping; D'Alessandro, Angelo; Wellendorf, Ashley M; Mohmoud, Fatima; Serrano-Lopez, Juana; Perentesis, John P; Komurov, Kakajan; Alexe, Gabriela; Stegmaier, Kimberly; Whitsett, Jeffrey A; Grimes, H Leighton; Cancelas, Jose A 2018. KLF5 controls glutathione metabolism to suppress p190-BCR-ABL+ B-cell lymphoblastic leukemia. Oncotarget, 9 51, 29665-29679

Cancelas, J A; Gottschall, J L; Rugg, N; Graminske, S; Schott, M A; North, A; Huang, N; Mufti, N; Erickson, A; Rico, S; Corash, L 2017. Red blood cell concentrates treated with the amustaline (S-303) pathogen reduction system and stored for 35 days retain post-transfusion viability: results of a two-centre study. Vox sanguinis, 112 3, 210-218

Cancelas, Jose A; Rugg, Neeta; Nestheide, Shawnagay; Hill, Sarah E; Emanuele, R Martin; Mckenzie, Douglas S 2017. The purified vepoloxamer prevents haemolysis in 42-day stored, DEHP/PVC-free red blood cell units. Blood transfusion = Trasfusione del sangue, 15 2, 165-171

Cancelas, Jose A; Slichter, Sherrill J; Rugg, Neeta; Pratt, P Gayle; Nestheide, Shawnagay; Corson, Jill; Pellham, Esther; Huntington, Marty; Goodrich, Raymond P 2017. Red blood cells derived from whole blood treated with riboflavin and ultraviolet light maintain adequate survival in vivo after 21 days of storage. Transfusion, 57 5, 1218-1225

Choi, Kwangmin; Komurov, Kakajan; Fletcher, Jonathan S; Jousma, Edwin; Cancelas, Jose A; Wu, Jianqiang; Ratner, Nancy 2017. An inflammatory gene signature distinguishes neurofibroma Schwann cells and macrophages from cells in the normal peripheral nervous system. Scientific reports, 7 , 43315

Daily, Kenneth; Ho Sui, Shannan J; Schriml, Lynn M; Dexheimer, Phillip J; Salomonis, Nathan; Schroll, Robin; Bush, Stacy; Keddache, Mehdi; Mayhew, Christopher; Lotia, Samad; Perumal, Thanneer M; Dang, Kristen; Pantano, Lorena; Pico, Alexander R; Grassman, Elke; Nordling, Diana; Hide, Winston; Hatzopoulos, Antonis K; Malik, Punam; Cancelas, Jose A; Lutzko, Carolyn; Aronow, Bruce J; Omberg, Larsson 2017. Molecular, phenotypic, and sample-associated data to describe pluripotent stem cell lines and derivatives. Scientific data, 4 , 170030

Guidi, Novella; Sacma, Mehmet; Ständker, Ludger; Soller, Karin; Marka, Gina; Eiwen, Karina; Weiss, Johannes M; Kirchhoff, Frank; Weil, Tanja; Cancelas, Jose A; Florian, Maria Carolina; Geiger, Hartmut 2017. Osteopontin attenuates aging-associated phenotypes of hematopoietic stem cells. The EMBO journal, 36 10, 1463

Guidi, Novella; Sacma, Mehmet; Ständker, Ludger; Soller, Karin; Marka, Gina; Eiwen, Karina; Weiss, Johannes M; Kirchhoff, Frank; Weil, Tanja; Cancelas, Jose A; Florian, Maria Carolina; Geiger, Hartmut 2017. Osteopontin attenuates aging-associated phenotypes of hematopoietic stem cells. The EMBO journal, 36 7, 840-853

Kesarwani, Meenu; Kincaid, Zachary; Gomaa, Ahmed; Huber, Erika; Rohrabaugh, Sara; Siddiqui, Zain; Bouso, Muhammad F; Latif, Tahir; Xu, Ming; Komurov, Kakajan; Mulloy, James C; Cancelas, Jose A; Grimes, H Leighton; Azam, Mohammad 2017. Targeting c-FOS and DUSP1 abrogates intrinsic resistance to tyrosine-kinase inhibitor therapy in BCR-ABL-induced leukemia. Nature medicine, 23 4, 472-482

Noel, John G; Ramser, Benjamin J; Cancelas, Jose A; McCormack, Francis X; Gardner, Jason C 2017. Thermal injury of the skin induces G-CSF-dependent attenuation of EPO-mediated STAT signaling and erythroid differentiation arrest in mice. Experimental hematology, 56 , 16-30

Schmidt, Robert L; Mock, Donald M; Franco, Robert S; Cohen, Robert M; North, Anne K; Cancelas, José A; Geisen, Christof; Strauss, Ronald G; Vlaar, Alexander P; Nalbant, Demet; Widness, John A 2017. Antibodies to biotinylated red blood cells in adults and infants: improved detection, partial characterization, and dependence on red blood cell-biotin dose. Transfusion, 57 6, 1488-1496

Worsham, D Nicole; Reems, Jo-Anna; Szczepiorkowski, Zbigniew M; McKenna, David H; Leemhuis, Thomas; Mathew, Aby J; Cancelas, Jose A 2017. Clinical methods of cryopreservation for donor lymphocyte infusions vary in their ability to preserve functional T-cell subpopulations. Transfusion, 57 6, 1555-1565

Cancelas, Jose A; Rugg, Neeta 2016. Plasma Protein Timings: Relative Contributions of Storage Time, Donor Age and Donation Season. EBioMedicine, 12 , 32-33

Cancelas, Jose A; Scott, Edward P; Bill, Jerome R 2016. Continuous CD34+ cell collection by a new device is safe and more efficient than by a standard collection procedure: results of a two-center, crossover, randomized trial. Transfusion, 56 11, 2824-2832

Hegde, Shailaja; Cancelas, Jose A 2016. Dissecting the metabolic pathways controlling platelet survival in vivo: are our platelets what they eat? Transfusion, 56 8, 1928-31

Salomonis, Nathan; Dexheimer, Phillip J; Omberg, Larsson; Schroll, Robin; Bush, Stacy; Huo, Jeffrey; Schriml, Lynn; Ho Sui, Shannan; Keddache, Mehdi; Mayhew, Christopher; Shanmukhappa, Shiva Kumar; Wells, James; Daily, Kenneth; Hubler, Shane; Wang, Yuliang; Zambidis, Elias; Margolin, Adam; Hide, Winston; Hatzopoulos, Antonis K; Malik, Punam; Cancelas, Jose A; Aronow, Bruce J; Lutzko, Carolyn 2016. Integrated Genomic Analysis of Diverse Induced Pluripotent Stem Cells from the Progenitor Cell Biology Consortium. Stem cell reports, 7 1, 110-25

Serrano-Lopez, Juana; Cancelas, Jose A 2016. Mom Knows Best: Imprinted Control of Hematopoietic Stem Cell Quiescence. Cell stem cell, 18 2, 158-60

Wu, Jianqiang; Keng, Vincent W; Patmore, Deanna M; Kendall, Jed J; Patel, Ami V; Jousma, Edwin; Jessen, Walter J; Choi, Kwangmin; Tschida, Barbara R; Silverstein, Kevin A T; Fan, Danhua; Schwartz, Eric B; Fuchs, James R; Zou, Yuanshu; Kim, Mi-Ok; Dombi, Eva; Levy, David E; Huang, Gang; Cancelas, Jose A; Stemmer-Rachamimov, Anat O; Spinner, Robert J; Largaespada, David A; Ratner, Nancy 2016. Insertional Mutagenesis Identifies a STAT3/Arid1b/?-catenin Pathway Driving Neurofibroma Initiation. Cell reports, 14 8, 1979-90

Cancelas, Jose A 2015. Granulocyte transfusion: questions remain. Blood, 126 18, 2082-3

Cancelas, Jose A; Dumont, Larry J; Maes, Lou A; Rugg, Neeta; Herschel, Louise; Whitley, Pamela H; Szczepiokowski, Zbigniew M; Siegel, Alan H; Hess, John R; Zia, Majid 2015. Additive solution-7 reduces the red blood cell cold storage lesion. Transfusion, 55 3, 491-8

Chang, Kyung Hee; Nayak, Ramesh C; Roy, Swarnava; Perumbeti, Ajay; Wellendorf, Ashley M; Bezold, Katie Y; Pirman, Megan; Hill, Sarah E; Starnes, Joseph; Loberg, Anastacia; Zhou, Xuan; Inagami, Tadashi; Zheng, Yi; Malik, Punam; Cancelas, Jose A 2015. Vasculopathy-associated hyperangiotensinemia mobilizes haematopoietic stem cells/progenitors through endothelial AT?R and cytoskeletal dysregulation. Nature communications, 6 , 5914

Dumont, Larry J; Cancelas, Jose A; Maes, Lou Ann; Rugg, Neeta; Whitley, Pamela; Herschel, Louise; Siegal, Alan H; Szczepiorkowski, Zbigniew M; Hess, John R; Zia, Majid 2015. Overnight, room temperature hold of whole blood followed by 42-day storage of red blood cells in additive solution-7. Transfusion, 55 3, 485-90

Dumont, Larry J; Cancelas, Jose A; Maes, Lou Ann; Rugg, Neeta; Whitley, Pamela; Herschel, Louise; Siegel, Alan H; Szczepiorkowski, Zbigniew M; Hess, John R; Zia, Majid 2015. The bioequivalence of frozen plasma prepared from whole blood held overnight at room temperature compared to fresh-frozen plasma prepared within eight hours of collection. Transfusion, 55 3, 476-84

González-Nieto, Daniel; Chang, Kyung-Hee; Fasciani, Ilaria; Nayak, Ramesh; Fernandez-García, Laura; Barrio, Luis C; Cancelas, José A 2015. Connexins: Intercellular Signal Transmitters in Lymphohematopoietic Tissues. International review of cell and molecular biology, 318 , 27-62

Nayak, Ramesh C; Trump, Lisa R; Aronow, Bruce J; Myers, Kasiani; Mehta, Parinda; Kalfa, Theodosia; Wellendorf, Ashley M; Valencia, C Alexander; Paddison, Patrick J; Horwitz, Marshall S; Grimes, H Leighton; Lutzko, Carolyn; Cancelas, Jose A 2015. Pathogenesis of ELANE-mutant severe neutropenia revealed by induced pluripotent stem cells. The Journal of clinical investigation, 125 8, 3103-16

Cancelas, Jose A; Padmanabhan, Anand; Le, Tuan; Ambruso, Daniel R; Rugg, Neeta; Worsham, D Nicole; Pinkard, Susan L; Graminske, Sharon; Buck, Jennifer; Goldberg, Julie; Bill, Jerry 2014. Spectra Optia granulocyte apheresis collections result in higher collection efficiency of viable, functional neutrophils in a randomized, crossover, multicenter trial. Transfusion, ,

Chang, Kyung Hee; Sengupta, Amitava; Nayak, Ramesh C; Duran, Angeles; Lee, Sang Jun; Pratt, Ronald G; Wellendorf, Ashley M; Hill, Sarah E; Watkins, Marcus; Gonzalez-Nieto, Daniel; Aronow, Bruce J; Starczynowski, Daniel T; Civitelli, Roberto; Diaz-Meco, Maria T; Moscat, Jorge; Cancelas, Jose A 2014. p62 is required for stem cell/progenitor retention through inhibition of IKK/NF-?B/Ccl4 signaling at the bone marrow macrophage-osteoblast niche. Cell reports, 9 6, 2084-97

Fang, Jing; Barker, Brenden; Bolanos, Lyndsey; Liu, Xiaona; Jerez, Andres; Makishima, Hideki; Christie, Susanne; Chen, Xiaoting; Rao, Dinesh S; Grimes, H Leighton; Komurov, Kakajan; Weirauch, Matthew T; Cancelas, Jose A; Maciejewski, Jaroslaw P; Starczynowski, Daniel T 2014. Myeloid malignancies with chromosome 5q deletions acquire a dependency on an intrachromosomal NF-?B gene network. Cell reports, 8 5, 1328-38

Mock, Donald M; Widness, John A; Veng-Pedersen, Peter; Strauss, Ronald G; Cancelas, Jose A; Cohen, Robert M; Lindsell, Christopher J; Franco, Robert S 2014. Measurement of posttransfusion red cell survival with the biotin label. Transfusion medicine reviews, 28 3, 114-25

Privette Vinnedge, L M; Benight, N M; Wagh, P K; Pease, N A; Nashu, M A; Serrano-Lopez, J; Adams, A K; Cancelas, J A; Waltz, S E; Wells, S I 2014. The DEK oncogene promotes cellular proliferation through paracrine Wnt signaling in Ron receptor-positive breast cancers. Oncogene, ,

Tidwell, Timothy; Wechsler, Jeremy; Nayak, Ramesh C; Trump, Lisa; Salipante, Stephen J; Cheng, Jerry C; Donadieu, Jean; Glaubach, Taly; Corey, Seth J; Grimes, H Leighton; Lutzko, Carolyn; Cancelas, Jose A; Horwitz, Marshall S 2014. Neutropenia-associated ELANE mutations disrupting translation initiation produce novel neutrophil elastase isoforms. Blood, 123 4, 562-9

Velu, Chinavenmeni S; Chaubey, Aditya; Phelan, James D; Horman, Shane R; Wunderlich, Mark; Guzman, Monica L; Jegga, Anil G; Zeleznik-Le, Nancy J; Chen, Jianjun; Mulloy, James C; Cancelas, Jose A; Jordan, Craig T; Aronow, Bruce J; Marcucci, Guido; Bhat, Balkrishen; Gebelein, Brian; Grimes, H Leighton 2014. Therapeutic antagonists of microRNAs deplete leukemia-initiating cell activity. The Journal of clinical investigation, 124 1, 222-36

Yamada, Yoshiyuki; Cancelas, Jose A; Rothenberg, Marc E 2014. Murine models of eosinophilic leukemia: a model of FIP1L1-PDGFR? initiated chronic eosinophilic leukemia/systemic mastocytosis. Methods in molecular biology (Clifton, N.J.), 1178 , 309-20

Dumont, Larry J; Cancelas, Jose A; Dumont, Deborah F; Siegel, Alan H; Szczepiorkowski, Zbigniew M; Rugg, Neeta; Pratt, P Gayle; Worsham, D Nicole; Hartman, Elizabeth L; Dunn, Susan K; O'Leary, Margaret; Ransom, Janet H; Michael, Rodney A; Macdonald, Victor W 2013. A randomized controlled trial evaluating recovery and survival of 6% dimethyl sulfoxide-frozen autologous platelets in healthy volunteers. Transfusion, 53 1, 128-37

Dumont, Larry J; Cancelas, Jose A; Graminske, Sharon; Friedman, Kenneth D; Vassallo, Ralph R; Whitley, Pamela H; Rugg, Neeta; Dumont, Deborah F; Herschel, Louise; Siegal, Alan H; Szczepiorkowski, Zbigniew M; Fender, Logan; Razatos, Anna 2013. In vitro and in vivo quality of leukoreduced apheresis platelets stored in a new platelet additive solution. Transfusion, 53 5, 972-80

Guo, Fukun; Zhang, Shuangmin; Grogg, Matthew; Cancelas, Jose A; Varney, Melinda E; Starczynowski, Daniel T; Du, Wei; Yang, Jun-Qi; Liu, Wei; Thomas, George; Kozma, Sara; Pang, Qishen; Zheng, Yi 2013. Mouse gene targeting reveals an essential role of mTOR in hematopoietic stem cell engraftment and hematopoiesis. Haematologica, 98 9, 1353-8

Mayes, Debra A; Rizvi, Tilat A; Titus-Mitchell, Haley; Oberst, Rachel; Ciraolo, Georgianne M; Vorhees, Charles V; Robinson, Andrew P; Miller, Stephen D; Cancelas, Jose A; Stemmer-Rachamimov, Anat O; Ratner, Nancy 2013. Nf1 loss and Ras hyperactivation in oligodendrocytes induce NOS-driven defects in myelin and vasculature. Cell reports, 4 6, 1197-212

Nayak, Ramesh C; Chang, Kyung-Hee; Vaitinadin, Nataraja-Sarma; Cancelas, Jose A 2013. Rho GTPases control specific cytoskeleton-dependent functions of hematopoietic stem cells. Immunological reviews, 256 1, 255-68

Prada, Carlos E; Jousma, Edwin; Rizvi, Tilat A; Wu, Jianqiang; Dunn, R Scott; Mayes, Debra A; Cancelas, Jose A; Dombi, Eva; Kim, Mi-Ok; West, Brian L; Bollag, Gideon; Ratner, Nancy 2013. Neurofibroma-associated macrophages play roles in tumor growth and response to pharmacological inhibition. Acta neuropathologica, 125 1, 159-68

Raman, R; Kumar, R S; Hinge, A; Kumar, S; Nayak, R; Xu, J; Szczur, K; Cancelas, J A; Filippi, M-D 2013. p190-B RhoGAP regulates the functional composition of the mesenchymal microenvironment. Leukemia, 27 11, 2209-19

Taniguchi Ishikawa, E; Chang, K H; Nayak, R; Olsson, H A; Ficker, A M; Dunn, S K; Madhu, M N; Sengupta, A; Whitsett, J A; Grimes, H L; Cancelas, J A 2013. Klf5 controls bone marrow homing of stem cells and progenitors through Rab5-mediated ?1/?2-integrin trafficking. Nature communications, 4 , 1660

Zhou, Xuan; Florian, Maria Carolina; Arumugam, Paritha; Chen, Xiaoyi; Cancelas, Jose A; Lang, Richard; Malik, Punam; Geiger, Hartmut; Zheng, Yi 2013. RhoA GTPase controls cytokinesis and programmed necrosis of hematopoietic progenitors. The Journal of experimental medicine, 210 11, 2371-85

Chang, Kyung Hee; Sanchez-Aguilera, Abel; Shen, Shuhong; Sengupta, Amitava; Madhu, Malav N; Ficker, Ashley M; Dunn, Susan K; Kuenzi, Ashley M; Arnett, Jorden L; Santho, Rebecca A; Agirre, Xabier; Perentesis, John P; Deininger, Michael W; Zheng, Yi; Bustelo, Xose R; Williams, David A; Cancelas, Jose A 2012. Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival. Blood, 120 4, 800-11

Geiger, Hartmut; Pawar, Snehalata A; Kerschen, Edward J; Nattamai, Kalpana J; Hernandez, Irene; Liang, Hai Po H; Fernández, Jose Á; Cancelas, Jose A; Ryan, Marnie A; Kustikova, Olga; Schambach, Axel; Fu, Qiang; Wang, Junru; Fink, Louis M; Petersen, Karl-Uwe; Zhou, Daohong; Griffin, John H; Baum, Christopher; Weiler, Hartmut; Hauer-Jensen, Martin 2012. Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity. Nature medicine, 18 7, 1123-9

Gonzalez-Nieto, Daniel; Li, Lina; Kohler, Anja; Ghiaur, Gabriel; Ishikawa, Eri; Sengupta, Amitava; Madhu, Malav; Arnett, Jorden L; Santho, Rebecca A; Dunn, Susan K; Fishman, Glenn I; Gutstein, David E; Civitelli, Roberto; Barrio, Luis C; Gunzer, Matthias; Cancelas, Jose A 2012. Connexin-43 in the osteogenic BM niche regulates its cellular composition and the bidirectional traffic of hematopoietic stem cells and progenitors. Blood, 119 22, 5144-54

Ishikawa, Eri Taniguchi; Cancelas, Jose A 2012. Lack of communication rusts and ages stem cells. Cell cycle (Georgetown, Tex.), 11 17, 3149-50

Konstantinidis, Diamantis G; Pushkaran, Suvarnamala; Johnson, James F; Cancelas, Jose A; Manganaris, Stefanos; Harris, Chad E; Williams, David A; Zheng, Yi; Kalfa, Theodosia A 2012. Signaling and cytoskeletal requirements in erythroblast enucleation. Blood, 119 25, 6118-27

Sengupta, Amitava; Ficker, Ashley M; Dunn, Susan K; Madhu, Malav; Cancelas, Jose A 2012. Bmi1 reprograms CML B-lymphoid progenitors to become B-ALL-initiating cells. Blood, 119 2, 494-502

Taniguchi Ishikawa, Eri; Gonzalez-Nieto, Daniel; Ghiaur, Gabriel; Dunn, Susan K; Ficker, Ashley M; Murali, Bhuvana; Madhu, Malav; Gutstein, David E; Fishman, Glenn I; Barrio, Luis C; Cancelas, Jose A 2012. Connexin-43 prevents hematopoietic stem cell senescence through transfer of reactive oxygen species to bone marrow stromal cells. Proceedings of the National Academy of Sciences of the United States of America, 109 23, 9071-6

Cancelas, J A 2011. On how Rac controls hematopoietic stem cell activity. Transfusion, 51 Suppl 4 , 153S-159S

Cancelas, Jose A 2011. Adhesion, migration, and homing of murine hematopoietic stem cells and progenitors. Methods in molecular biology (Clifton, N.J.), 750 , 187-96

Cancelas, Jose A; Dumont, Larry J; Rugg, Neeta; Szczepiorkowski, Zbigniew M; Herschel, Louis; Siegel, Alan; Pratt, P Gayle; Worsham, D Nicole; Erickson, Anne; Propst, Meisa; North, Anne; Sherman, Claire D; Mufti, Nina A; Reed, William F; Corash, Laurence 2011. Stored red blood cell viability is maintained after treatment with a second-generation S-303 pathogen inactivation process. Transfusion, 51 11, 2367-76

Cancelas, Jose A; Rugg, Neeta; Fletcher, Dana; Pratt, P Gayle; Worsham, D Nicole; Dunn, Susan K; Marschner, Susanne; Reddy, Heather L; Goodrich, Raymond P 2011. In vivo viability of stored red blood cells derived from riboflavin plus ultraviolet light-treated whole blood. Transfusion, 51 7, 1460-8

Cancelas, Jose A; Rugg, Neeta; Pratt, P Gayle; Worsham, D Nicole; Pehta, Joan C; Banks, Kate; Davenport, Robertson D; Judd, W John 2011. Infusion of P-Capt prion-filtered red blood cell products demonstrate acceptable in vivo viability and no evidence of neoantigen formation. Transfusion, 51 10, 2228-36

Cardigan, R; Van der Meer, P F; Pergande, C; Cookson, P; Baumann-Baretti, B; Cancelas, J A; Devine, D; Gulliksson, H; Vassallo, R; de Wildt-Eggen, J 2011. Coagulation factor content of plasma produced from whole blood stored for 24 hours at ambient temperature: results from an international multicenter BEST Collaborative study. Transfusion, 51 Suppl 1 , 50S-57S

Mayes, Debra A; Rizvi, Tilat A; Cancelas, Jose A; Kolasinski, Nathan T; Ciraolo, Georgianne M; Stemmer-Rachamimov, Anat O; Ratner, Nancy 2011. Perinatal or adult Nf1 inactivation using tamoxifen-inducible PlpCre each cause neurofibroma formation. Cancer research, 71 13, 4675-85

Sengupta, Amitava; Cancelas, Jose A 2011. A conundrum in mammalian hematopoietic stem cell polarity. Cell cycle (Georgetown, Tex.), 10 24, 4191-2

Sengupta, Amitava; Duran, Angeles; Ishikawa, Eri; Florian, Maria Carolina; Dunn, Susan K; Ficker, Ashley M; Leitges, Michael; Geiger, Hartmut; Diaz-Meco, Maria; Moscat, Jorge; Cancelas, Jose A 2011. Atypical protein kinase C (aPKCzeta and aPKClambda) is dispensable for mammalian hematopoietic stem cell activity and blood formation. Proceedings of the National Academy of Sciences of the United States of America, 108 24, 9957-62

Shang, Xun; Cancelas, Jose A; Li, Lina; Guo, Fukun; Liu, Wei; Johnson, James F; Ficker, Ashley; Daria, Deidre; Geiger, Hartmut; Ratner, Nancy; Zheng, Yi 2011. R-Ras and Rac GTPase cross-talk regulates hematopoietic progenitor cell migration, homing, and mobilization. The Journal of biological chemistry, 286 27, 24068-78

van der Meer, Pieter F; Cancelas, Jose A; Cardigan, Rebecca; Devine, Dana V; Gulliksson, Hans; Sparrow, Rosemary L; Vassallo, Ralph R; de Wildt-Eggen, Janny; Baumann-Baretti, Bärbel; Hess, John R 2011. Evaluation of overnight hold of whole blood at room temperature before component processing: effect of red blood cell (RBC) additive solutions on in vitro RBC measures. Transfusion, 51 Suppl 1 , 15S-24S

van der Meer, Pieter F; Cancelas, Jose A; Vassallo, Ralph R; Rugg, Neeta; Einarson, Mindy; Hess, John R 2011. Evaluation of the overnight hold of whole blood at room temperature, before component processing: platelets (PLTs) from PLT-rich plasma. Transfusion, 51 Suppl 1 , 45S-49S

Kalfa, Theodosia A; Pushkaran, Suvarnamala; Zhang, Xiaoling; Johnson, James F; Pan, Dao; Daria, Deidre; Geiger, Hartmut; Cancelas, Jose A; Williams, David A; Zheng, Yi 2010. Rac1 and Rac2 GTPases are necessary for early erythropoietic expansion in the bone marrow but not in the spleen. Haematologica, 95 1, 27-35

Miller, S J; Lan, Z D; Hardiman, A; Wu, J; Kordich, J J; Patmore, D M; Hegde, R S; Cripe, T P; Cancelas, J A; Collins, M H; Ratner, N 2010. Inhibition of Eyes Absent Homolog 4 expression induces malignant peripheral nerve sheath tumor necrosis. Oncogene, 29 3, 368-79

Mulloy, James C; Cancelas, Jose A; Filippi, Marie-Dominique; Kalfa, Theodosia A; Guo, Fukun; Zheng, Yi 2010. Rho GTPases in hematopoiesis and hemopathies. Blood, 115 5, 936-47

Ryan, Marnie A; Nattamai, Kalpana J; Xing, Ellen; Schleimer, David; Daria, Deidre; Sengupta, Amitava; Köhler, Anja; Liu, Wei; Gunzer, Matthias; Jansen, Michael; Ratner, Nancy; Le Cras, Timothy D; Waterstrat, Amanda; Van Zant, Gary; Cancelas, Jose A; Zheng, Yi; Geiger, Hartmut 2010. Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilization. Nature medicine, 16 10, 1141-6

Sanchez-Aguilera, A; Rattmann, I; Drew, D Z; Müller, L U W; Summey, V; Lucas, D M; Byrd, J C; Croce, C M; Gu, Y; Cancelas, J A; Johnston, P; Moritz, T; Williams, D A 2010. Involvement of RhoH GTPase in the development of B-cell chronic lymphocytic leukemia. Leukemia, 24 1, 97-104

Sengupta, Amitava; Arnett, Jorden; Dunn, Susan; Williams, David A; Cancelas, Jose A 2010. Rac2 GTPase deficiency depletes BCR-ABL+ leukemic stem cells and progenitors in vivo. Blood, 116 1, 81-4

Sengupta, Amitava; Cancelas, Jose A 2010. Cancer stem cells: a stride towards cancer cure? Journal of cellular physiology, 225 1, 7-14

Yamada, Yoshiyuki; Cancelas, Jose A 2010. FIP1L1/PDGFR alpha-associated systemic mastocytosis. International archives of allergy and immunology, 152 Suppl 1 , 101-5

Cancelas, Jose A; Williams, David A 2009. Rho GTPases in hematopoietic stem cell functions. Current opinion in hematology, 16 4, 249-54

Mahller, Yonatan Y; Williams, Jon P; Baird, William H; Mitton, Bryan; Grossheim, Jonathan; Saeki, Yoshinaga; Cancelas, Jose A; Ratner, Nancy; Cripe, Timothy P 2009. Neuroblastoma cell lines contain pluripotent tumor initiating cells that are susceptible to a targeted oncolytic virus. PloS one, 4 1, e4235

Milsom, Michael D; Lee, Andrew W; Zheng, Yi; Cancelas, Jose A 2009. Fanca-/- hematopoietic stem cells demonstrate a mobilization defect which can be overcome by administration of the Rac inhibitor NSC23766. Haematologica, 94 7, 1011-5

Yamada, Yoshiyuki; Cancelas, Jose A; Rothenberg, Marc E 2009. Murine model of hypereosinophilic syndromes/chronic eosinophilic leukemia. International archives of allergy and immunology, 149 Suppl 1 , 102-7

Ghiaur, Gabriel; Ferkowicz, Michael J; Milsom, Michael D; Bailey, Jeff; Witte, David; Cancelas, Jose A; Yoder, Mervin C; Williams, David A 2008. Rac1 is essential for intraembryonic hematopoiesis and for the initial seeding of fetal liver with definitive hematopoietic progenitor cells. Blood, 111 7, 3313-21

Guo, Fukun; Cancelas, Jose A; Hildeman, David; Williams, David A; Zheng, Yi 2008. Rac GTPase isoforms Rac1 and Rac2 play a redundant and crucial role in T-cell development. Blood, 112 5, 1767-75

Mahller, Yonatan Y; Vaikunth, Sachin S; Ripberger, Maria C; Baird, William H; Saeki, Yoshinaga; Cancelas, Jose A; Crombleholme, Timothy M; Cripe, Timothy P 2008. Tissue inhibitor of metalloproteinase-3 via oncolytic herpesvirus inhibits tumor growth and vascular progenitors. Cancer research, 68 4, 1170-9

Müller, L U W; Schore, R J; Zheng, Y; Thomas, E K; Kim, M-O; Cancelas, J A; Gu, Y; Williams, D A 2008. Rac guanosine triphosphatases represent a potential target in AML. Leukemia, 22 9, 1803-6

Thomas, E K; Cancelas, J A; Zheng, Y; Williams, D A 2008. Rac GTPases as key regulators of p210-BCR-ABL-dependent leukemogenesis. Leukemia, 22 5, 898-904

Wei, Junping; Wunderlich, Mark; Fox, Catherine; Alvarez, Sara; Cigudosa, Juan C; Wilhelm, Jamie S; Zheng, Yi; Cancelas, Jose A; Gu, Yi; Jansen, Michael; Dimartino, Jorge F; Mulloy, James C 2008. Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia. Cancer cell, 13 6, 483-95

Williams, David A; Zheng, Yi; Cancelas, Jose A 2008. Rho GTPases and regulation of hematopoietic stem cell localization. Methods in enzymology, 439 , 365-93

Williams, Jon P; Wu, Jianqiang; Johansson, Gunnar; Rizvi, Tilat A; Miller, Shyra C; Geiger, Hartmut; Malik, Punam; Li, Wenling; Mukouyama, Yoh-suke; Cancelas, Jose A; Ratner, Nancy 2008. Nf1 mutation expands an EGFR-dependent peripheral nerve progenitor that confers neurofibroma tumorigenic potential. Cell stem cell, 3 6, 658-69

Wu, Jianqiang; Williams, Jon P; Rizvi, Tilat A; Kordich, Jennifer J; Witte, David; Meijer, Dies; Stemmer-Rachamimov, Anat O; Cancelas, Jose A; Ratner, Nancy 2008. Plexiform and dermal neurofibromas and pigmentation are caused by Nf1 loss in desert hedgehog-expressing cells. Cancer cell, 13 2, 105-16

Yamada, Yoshiyuki; Sanchez-Aguilera, Abel; Brandt, Eric B; McBride, Melissa; Al-Moamen, Nabeel J H; Finkelman, Fred D; Williams, David A; Cancelas, Jose A; Rothenberg, Marc E 2008. FIP1L1/PDGFRalpha synergizes with SCF to induce systemic mastocytosis in a murine model of chronic eosinophilic leukemia/hypereosinophilic syndrome. Blood, 112 6, 2500-7

Akbar, H; Kim, J; Funk, K; Cancelas, J A; Shang, X; Chen, L; Johnson, J F; Williams, D A; Zheng, Y 2007. Genetic and pharmacologic evidence that Rac1 GTPase is involved in regulation of platelet secretion and aggregation. Journal of thrombosis and haemostasis : JTH, 5 8, 1747-55

Kelly, Patrick F; Radtke, Susan; von Kalle, Christof; Balcik, Brenden; Bohn, Kimberley; Mueller, Robin; Schuesler, Todd; Haren, Moira; Reeves, Lilith; Cancelas, Jose A; Leemhuis, Thomas; Harris, Richard; Auerbach, Arleen D; Smith, Franklin O; Davies, Stella M; Williams, David A 2007. Stem cell collection and gene transfer in Fanconi anemia. Molecular therapy : the journal of the American Society of Gene Therapy, 15 1, 211-9

Thomas, Emily K; Cancelas, Jose A; Chae, Hee-Don; Cox, Adrienne D; Keller, Patricia J; Perrotti, Danilo; Neviani, Paolo; Druker, Brian J; Setchell, Kenneth D R; Zheng, Yi; Harris, Chad E; Williams, David A 2007. Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease. Cancer cell, 12 5, 467-78

Yang, Linda; Wang, Lei; Geiger, Hartmut; Cancelas, Jose A; Mo, Jun; Zheng, Yi 2007. Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrow. Proceedings of the National Academy of Sciences of the United States of America, 104 12, 5091-6

Yang, Linda; Wang, Lei; Kalfa, Theodosia A; Cancelas, Jose A; Shang, Xun; Pushkaran, Suvarnamala; Mo, Jun; Williams, David A; Zheng, Yi 2007. Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis. Blood, 110 12, 3853-61

AuBuchon, James P; Cancelas, Jose A; Herschel, Louise; Roger, Jill; Rugg, Neeta; Pratt, Patricia G; Joines, Amy; Gormas, Jennifer F; Zia, Majid; Spearman, Michael R 2006. In vitro and in vivo evaluation of LEUKOSEP HRC-600-C leukoreduction filtration system for red cells. Transfusion, 46 8, 1311-5

Cancelas, Jose A; Jansen, Michael; Williams, David A 2006. The role of chemokine activation of Rac GTPases in hematopoietic stem cell marrow homing, retention, and peripheral mobilization. Experimental hematology, 34 8, 976-85

Cancelas, Jose A; Williams, David A 2006. Stem cell mobilization by beta2-agonists. Nature medicine, 12 3, 278-9

Ghiaur, Gabriel; Lee, Andrew; Bailey, Jeff; Cancelas, Jose A; Zheng, Yi; Williams, David A 2006. Inhibition of RhoA GTPase activity enhances hematopoietic stem and progenitor cell proliferation and engraftment. Blood, 108 6, 2087-94

Williams, David A; Cancelas, Jose A 2006. Leukaemia: niche retreats for stem cells. Nature, 444 7121, 827-8

Williams, David A; Xu, Haiming; Cancelas, Jose A 2006. Children are not little adults: just ask their hematopoietic stem cells. The Journal of clinical investigation, 116 10, 2593-6

Yamada, Yoshiyuki; Rothenberg, Marc E; Cancelas, Jose A 2006. Current concepts on the pathogenesis of the hypereosinophilic syndrome/chronic eosinophilic leukemia. Translational oncogenomics, 1 , 53-63

Yamada, Yoshiyuki; Rothenberg, Marc E; Lee, Andrew W; Akei, Hiroko Saito; Brandt, Eric B; Williams, David A; Cancelas, Jose A 2006. The FIP1L1-PDGFRA fusion gene cooperates with IL-5 to induce murine hypereosinophilic syndrome (HES)/chronic eosinophilic leukemia (CEL)-like disease. Blood, 107 10, 4071-9

Cancelas, Jose A; Lee, Andrew W; Prabhakar, Rethinasamy; Stringer, Keith F; Zheng, Yi; Williams, David A 2005. Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization. Nature medicine, 11 8, 886-91

Chandra, Saurabh; Levran, Orna; Jurickova, Ingrid; Maas, Chiel; Kapur, Rick; Schindler, Detlev; Henry, Rashida; Milton, Kelly; Batish, Sat Dev; Cancelas, Jose A; Hanenberg, Helmut; Auerbach, Arleen D; Williams, David A 2005. A rapid method for retrovirus-mediated identification of complementation groups in Fanconi anemia patients. Molecular therapy : the journal of the American Society of Gene Therapy, 12 5, 976-84

Jansen, Michael; Yang, Feng-Chun; Cancelas, José A; Bailey, Jeff R; Williams, David A 2005. Rac2-deficient hematopoietic stem cells show defective interaction with the hematopoietic microenvironment and long-term engraftment failure. Stem cells (Dayton, Ohio), 23 3, 335-46

Gu, Yi; Filippi, Marie-Dominique; Cancelas, Jose A; Siefring, Jamie E; Williams, Emily P; Jasti, Aparna C; Harris, Chad E; Lee, Andrew W; Prabhakar, Rethinasamy; Atkinson, Simon J; Kwiatkowski, David J; Williams, David A 2003. Hematopoietic cell regulation by Rac1 and Rac2 guanosine triphosphatases. Science (New York, N.Y.), 302 5644, 445-9

Puig, T; Kádár, E; Limón, A; Cancelas, J A; Eixarch, H; Luquín, L; García, M; Barquinero, J 2002. Myeloablation enhances engraftment of transduced murine hematopoietic cells, but does not influence long-term expression of the transgene. Gene therapy, 9 21, 1472-9

Risques, R A; Moreno, V; Marcuello, E; Petriz, J; Cancelas, J A; Sancho, F J; Torregrosa, A; Capella, G; Peinado, M A 2001. Redefining the significance of aneuploidy in the prognostic assessment of colorectal cancer. Laboratory investigation; a journal of technical methods and pathology, 81 3, 307-15

Cancelas, J A; Koevoet, W L; de Koning, A E; Mayen, A E; Rombouts, E J; Ploemacher, R E 2000. Connexin-43 gap junctions are involved in multiconnexin-expressing stromal support of hemopoietic progenitors and stem cells. Blood, 96 2, 498-505

Cabezudo, E; Querol, S; Cancelas, J A; García, J 1999. Comparison of volumetric capillary cytometry with standard flow cytometry for routine enumeration of CD34+ cells. Transfusion, 39 8, 864-72

Capmany, G; Querol, S; Cancelas, J A; García, J 1999. Short-term, serum-free, static culture of cord blood-derived CD34+ cells: effects of FLT3-L and MIP-1alpha on in vitro expansion of hematopoietic progenitor cells. Haematologica, 84 8, 675-82

Petit, J; Boqué, C; Cancelas, J A; Sarrà, J; Muñoz, J; Garcia, J; Grañena, A 1999. Feasibility of ESHAP + G-CSF as peripheral blood hematopoietic progenitor cell mobilisation regimen in resistant and relapsed lymphoma: a single-center study of 22 patients. Leukemia & lymphoma, 34 1-2, 119-27

Querol, S; Cancelas, J A; Amat, L; Capmany, G; Garcia, J 1999. Effect of glycosylation of recombinant human granulocytic colony-stimulating factor on expansion cultures of umbilical cord blood CD34+ cells. Haematologica, 84 6, 493-8

Salazar, R; Solá, C; Maroto, P; Tabernero, J M; Brunet, J; Verger, G; Valentí, V; Cancelas, J A; Ojeda, B; Mendoza, L; Rodríguez, M; Montesinos, J; López-López, J J 1999. Infectious complications in 126 patients treated with high-dose chemotherapy and autologous peripheral blood stem cell transplantation. Bone marrow transplantation, 23 1, 27-33

Solá, C.; Maroto, P.; Salazar, R.; Mesía, R.; Mendoza, L.; Brunet, J.; López-Pousa, A.; Tabernero, J. M.; Montesinos, J.; Pericay, C.; Martínez, C.; Cancelas, J. A.; López-López, J. J. 1999. Bone Marrow Transplantation: Prognostic Factors of Peripheral Blood Stem Cell Mobilization with Cyclophosphamide and Filgrastim (r-metHuG-CSF): The CD34+ Cell Dose Positively Affects the Time to Hematopoietic Recovery and Supportive Requirements after High-Dose Chemotherapy. Hematology (Amsterdam, Netherlands), 4 3, 195-209

Martín-Satué, M; Marrugat, R; Cancelas, J A; Blanco, J 1998. Enhanced expression of alpha(1,3)-fucosyltransferase genes correlates with E-selectin-mediated adhesion and metastatic potential of human lung adenocarcinoma cells. Cancer research, 58 7, 1544-50

Querol, S; Capmany, G; Cancelas, J A; García, J 1998. Expansion of cord blood progenitor cells. Bone marrow transplantation, 21 Suppl 3 , S77-80

van Hennik, P B; Verstegen, M M; Bierhuizen, M F; Limón, A; Wognum, A W; Cancelas, J A; Barquinero, J; Ploemacher, R E; Wagemaker, G 1998. Highly efficient transduction of the green fluorescent protein gene in human umbilical cord blood stem cells capable of cobblestone formation in long-term cultures and multilineage engraftment of immunodeficient mice. Blood, 92 11, 4013-22

Canals, C; Torrico, C; Picón, M; Amill, B; Cancelas, J A; Fraga, G; Badell, I; Cubells, J; Olivé, T; Ortega, J; Vivancos, P; García, J 1997. Immunomagnetic bone marrow purging in children with acute lymphoblastic leukemia. Journal of hematotherapy, 6 3, 261-8

Gallardo, D; García-López, J; Sureda, A; Canals, C; Ferra, C; Cancelas, J A; Berlanga, J J; Brunet, S; Boqué, C; Picón, M; Torrico, C; Amill, B; Martino, R; Martínez, C; Martín-Henao, G; Domingo-Albós, A; Grañena, A 1997. Low-dose donor CD8+ cells in the CD4-depleted graft prevent allogeneic marrow graft rejection and severe graft-versus-host disease for chronic myeloid leukemia patients in first chronic phase. Bone marrow transplantation, 20 11, 945-52

Limón, A; Briones, J; Puig, T; Carmona, M; Fornas, O; Cancelas, J A; Nadal, M; García, J; Rueda, F; Barquinero, J 1997. High-titer retroviral vectors containing the enhanced green fluorescent protein gene for efficient expression in hematopoietic cells. Blood, 90 9, 3316-21

Martínez, C; Sureda, A; Martino, R; Cancelas, J A; Madoz, P; García, J; Brunet, S 1997. Efficient peripheral blood stem cell mobilization with low-dose G-CSF (50 microg/m2) after salvage chemotherapy for lymphoma. Bone marrow transplantation, 20 10, 855-8

Serke, S; Arseniev, L; Watts, M; Fritsch, G; Ingles-Esteve, J; Johnsen, H E; Linch, D; Cancelas, J A; Meyer, O; Kadar, J G; Huhn, D; Matcham, J 1997. Imprecision of counting CFU-GM colonies and CD34-expressing cells. Bone marrow transplantation, 20 1, 57-61

Boqué, C; Petit, J; Sarrá, J; Cancelas, J A; Muñoz, J; Español, J I; de la Banda, E; Aventin, A; Berlanga, J; Ferrá, C; Amill, B; Torrico, C; Azqueta, C; Llucià, M; García, J; Grañena, A 1996. Mobilization of peripheral stem cells with intensive chemotherapy (ICE regimen) and G-CSF in chronic myeloid leukemia. Bone marrow transplantation, 18 5, 879-84

Martín-Henao, G A; Inglés-Esteve, J; Cancelas, J A; García, J 1996. Isolation of CD34+ hematopoietic progenitor cells in chronic myeloid leukemia by magnetic activated cell sorting (MACS). Bone marrow transplantation, 18 3, 603-9

Cancelas, J A; Querol, S 1995. Graft failure after an umbilical cord blood transplant in a patient with severe aplastic anemia. Blood, 86 9, 3610

Cancelas, J A; Querol, S; Canals, C; Bertran, J; Limon, A; Amill, B; Petriz, J; Garcia-Lopez, J 1995. CD34+ cell positive selection from mobilized peripheral blood by an indirect immunomagnetic method: effect of the type of mobilization and assessment of tumor depletion ability. Journal of hematotherapy, 4 6, 531-8

López-Jimenez, J; Cancelas, J A; García-Laraña, J; Sastre, J L; Cerveró, C; Zamora, C; Megido, M; Hernández-Jodra, M; Lasa, E; Pérez-Oteyza, J 1995. Posttransfusion hepatitis after induction chemotherapy in acute nonlymphoblastic leukemia: implications for long-term management and outcome. Transfusion, 35 4, 313-8

Cancelas, J A; Alvarez, F; Navarro, J L; César, J M 1994. [Splenic irradiation as a treatment for chronic idiopathic thrombocytopenic purpura]. Sangre, 39 2, 152-3

Cancelas, J A; García-Avello, A; García-Frade, L J 1994. High plasma levels of plasminogen activator inhibitor 1 (PAI-1) in polycythemia vera and essential thrombocythemia are associated with thrombosis. Thrombosis research, 75 5, 513-20

Cancelas, J A; Hernández-Jodra, M; Zamora, C; Perez-Oteyza, J; Brieva, J A; Roldan, E; Navas, G; Garcia-Laraña, J; Lopez, J; Odriozola, J 1994. Circulating stem cell collection in lymphoma and myeloma after mobilization with cyclophosphamide and granulocyte colony-stimulating factor for autologous transplantation. Vox sanguinis, 67 4, 362-7

Cancelas, J A; Lopez, J; Cabezudo, E; Navas, E; Garcia Laraña, J; Jimenez Mena, M; Diz, P; Perez de Oteyza, J; Villalon, L; Sanchez-Sousa, A 1994. Native valve endocarditis due to Candida parapsilosis: a late complication after bone marrow transplantation-related fungemia. Bone marrow transplantation, 13 3, 333-4

Cancelas, J A; López-Jiménez, J; González, C; Calbo, M A; García Laraña, J 1994. [Cerebral toxoplasmosis with atypical presentation in a bone marrow transplant patient]. Medicina clínica, 103 10, 383-4

Garcia-Avello, A; Garcia-Frade, L J; Gandarias, C; Ocaña, J; Cancelas, J A; Lasso, M 1994. High F1.2 fragment of prothrombin, thrombin-antithrombin III complex (TAT) and soluble fibrin plasma levels demonstrate hypercoagulability induced during loco-regional thrombolytic therapy with rt-PA. Thrombosis research, 73 2, 109-15

López, J; Cancelas, J A; Valiño, J M; García-Laraña, J; Sastre, J L; Pérez-Oteyza, J; Cerveró, C; García-Avello, A; Cabezudo, E; Arranz, M I 1994. [Pentoxifylline is not useful in the prevention of toxicity associated with bone marrow transplantation]. Medicina clínica, 102 13, 485-8

Lopez-Jimenez, J; Cancelas, J A; Valiño, J M; Garcia-Laraña, J; Garcia-Avello, A; Arranz, M I; Perez-Oteyza, J; Ramos, P; Odriozola, J 1994. Effects of oral pentoxifylline on TNF-alpha levels, transplant-related toxicities and engraftment after bone marrow transplantation. Bone marrow transplantation, 14 6, 1011-2

Lousa, M; Sastre, J L; Cancelas, J A; Gobernado, J M; Pardo, A 1994. Study of antiphospholipid antibodies in a patient with Sneddon's syndrome and her family. Stroke; a journal of cerebral circulation, 25 5, 1071-4

Sastre, J L; Escribano, L; Montilla, P; Ulibarrena, C; Cancelas, J A 1994. [Hypereosinophilic syndrome induced by GM-CSF in a patient with AIDS. Possible response to alpha-interferon treatment]. Sangre, 39 5, 398-9

Sastre, J L; Pérez-Oteyza, J; López, J; Cerveró, C; Sánchez-Sousa, A; García-Laraña, J; Cancelas, J A; Odriozola, J; Navarro, J L 1994. [Pulmonary mucormycosis in leukemic patients. Apropos of 2 cases]. Sangre, 39 1, 53-5

Lopez, J; Ulibarrena, C; Gonzalez-Porque, P; Navas, G; Roldan, E; Cancelas, J A; Perez-Oteyza, J; Burgaleta, C; García-Laraña, J; Sastre, J L 1993. Amylase-producing Bence Jones multiple myeloma with pancreatitis-like symptoms. Acta haematologica, 90 2, 99-101

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