Office of Research
Clinical Trials

Leading the Future of Clinical Medicine
The College of Medicine is a hub for groundbreaking clinical research. With over 30 specialized research units, our teams are dedicated to translating laboratory discoveries into life-saving clinical applications. From neurology to oncology, we provide the infrastructure and expertise necessary to push the boundaries of modern medicine.

Browse our Research Units below to view current study listings.

Clinical Trials Search

Brian Grawe, MD

Brian Grawe, MD

Sports

Studying Whether Tranexamic Acid Improves Visualization and Recovery in Rotator Cuff Surgery

This study is testing whether adding a small amount of tranexamic acid (TXA), a medication that helps reduce bleeding, to the irrigation fluid used during shoulder arthroscopy can improve the clarity of the surgical view and affect early recovery. When surgeons operate with a camera inside the shoulder, bleeding can cloud the view, making surgery more difficult. TXA might help reduce this bleeding. Adults who are scheduled for arthroscopic rotator cuff repair may be invited to join. After giving consent, patients are randomly assigned to one of two groups: Standard saline irrigation, or Saline irrigation with a low dose of TXA mixed in. Neither the patient nor the surgeon will know which one is used to keep the study fair. The surgery is performed using the usual minimally invasive technique. The video from the procedure is recorded so that surgeons can later rate how clear the view was at different points in the operation. After surgery, patients will have their shoulder movement checked, complete short surveys, measure pain at 8, 24, and 48 hours, and have their swelling measured. Doctors will also review the medical record for information such as operative time, bleeding, hemoglobin changes, and any complications. Patients continue routine clinic follow‑up at 6 weeks and then at 3, 6, 12, and 24 months, completing questionnaires about pain, function, and health. All visits are part of standard postoperative care; no extra visits are required. The purpose of this double‑blind study is to find out whether TXA can safely improve visualization during surgery and possibly help with pain control or reduce complications. The results may help guide future shoulder surgery practices.

Toan T. Le, MD

Toan T. Le, MD

Joints

Phase 2

Cyclic Irrigation Expanded Access

This expanded access program offers the VT-X7 system, which delivers vancomycin and tobramycin by cyclic irrigation, to people having exchange surgery to treat a prosthetic joint infection (PJI) of the hip or knee who lack other treatment options. Eligible people are adults 22 to 84 years old who are scheduled for implant removal and who have a confirmed PJI. The program is for patients who may have failed prior exchange surgery. Certain people are not allowed to join, including those with recent bloodstream infection, infection in more than one joint, severe kidney disease, pregnancy, known allergies to the study antibiotics or certain implant materials, active cancer chemotherapy, high dose steroids, some immune problems, recent substance abuse, or other issues that would make study participation unsafe. Treatment involves the surgical removal of the prosthesis and use of the VT-X7 irrigation system during the exchange procedure, with hospital care and follow-up as directed by the study site. The aim is to give access to this antibiotic irrigation approach and to observe how well it is tolerated and works for these patients.

Learn More about Cyclic Irrigation Expanded Access
Brian Grawe, MD

Brian Grawe, MD

Sports

Comparing Two Biceps Tenodesis Techniques to Understand Recovery and Shoulder Function

This study compares two common ways of performing biceps tenodesis, a surgery used to treat shoulder pain caused by problems with the biceps tendon. One method, done by Dr. Grawe, uses an arthroscope and repairs the tendon above the pectoral muscle (arthroscopic supra‑pectoral). The other method, used by Dr. Utz, Dr. Summers, and Dr. Branam, uses an open incision below the muscle (open sub‑pectoral). Both are standard procedures used widely in shoulder surgery. Adults who are advised to undergo biceps tenodesis may be invited to participate. After agreeing to join the study, patients will complete short questionnaires about shoulder function and general health, and their shoulder motion will be measured. The type of surgery they receive will be based on the surgeon performing the procedure-not by randomization. After surgery, participants return for follow‑up visits at 6 weeks and at 3, 6, 12, and 24 months. At these visits, doctors check healing, shoulder movement, and symptoms. Patients also complete questionnaires to track pain and shoulder function. A routine ultrasound at the 3‑month visit helps evaluate how the tendon is healing. The study also includes a scar assessment to understand patient satisfaction with the appearance of their incision. The purpose of the study is to learn whether one surgical technique leads to better recovery, improved strength, less pain, or better cosmetic results. Both surgeries are standard treatments and pose no additional risks or costs beyond normal care. The information learned will help guide future patients and surgeons in choosing the most effective approach for biceps tendon problems.

Samir Sabharwal, MD

Samir Sabharwal, MD

Oncology

Comparing Two Surgical Options for Stabilizing Metastatic Bone Disease in the Upper Thigh (PERFORM)

The PERFORM study is a major international research trial comparing two ways of treating cancer‑related bone disease in the upper part of the thigh bone (proximal femur). Some patients develop weak or broken bones in this area when cancer spreads to the skeleton, and surgery is often needed to help them walk safely and reduce pain. The study compares two surgical options: Resection and reconstruction - removing the damaged section of bone and replacing it with an implant. Internal fixation - strengthening the bone using plates, screws, or a rod placed inside the bone. Patients who qualify will be randomly assigned to one of the two procedures. Doctors want to know which option helps patients live longer, stay mobile, and spend more days at home during the year after surgery. The study also measures quality of life, physical function, pain levels, and time spent in hospitals or care facilities. About 334 patients from hospitals across Canada, the U.S., and other countries will participate. Everyone will be followed for one year after their surgery, with check‑ins and questionnaires at several time points. All surgeries and follow‑up visits are standard medical care. The goal of PERFORM is to provide strong evidence to guide surgeons on the best treatment for people with metastatic bone disease in the femur. By comparing these two common surgical approaches, the study will help determine which one offers better long‑term outcomes and quality of life for cancer patients.

Samir Sabharwal, MD

Samir Sabharwal, MD

Oncology

Using a Blood Test to Tailor Blood‑Clot Prevention After Surgery for Metastatic Bone Disease

Cancer patients with metastatic disease that has spread to the bones are at high risk for blood clots, especially after surgery. This study explores whether using a special blood test called thromboelastography (TEG) can help doctors choose the safest and most effective blood‑thinner medication for each individual patient. Before surgery, a small blood sample is tested using Rapid TEG to see how quickly and strongly the patient's blood forms clots. Based on this test, patients are placed into groups ranging from "low clotting tendency" to "high clotting tendency." Each group has a matching treatment plan to help prevent dangerous blood clots after surgery, using medications like aspirin or low‑molecular‑weight heparin (enoxaparin). All participants also have an ultrasound scan of both legs to check for blood clots before surgery, and a second scan six weeks later. Patients are monitored for signs of deep vein thrombosis (DVT), pulmonary embolism (PE), bleeding, need for transfusion, or return to the operating room. Participants complete short questionnaires measuring physical function, pain, and anxiety before surgery and again at several follow‑up visits through the first year. These help the research team understand how patients feel and function during recovery. No experimental treatments are used-only tests and medications that are already part of standard orthopedic and cancer care. The information learned will help doctors design a larger future study and may lead to more personalized, safer blood‑clot prevention for patients with metastatic bone disease.

H. Claude Sagi, MD

H. Claude Sagi, MD

Trauma

Using Exam Under Anesthesia to Guide Pelvic Surgery for Partially Unstable (B-Type) Injuries

This study will help surgeons decide how best to treat certain partially unstable pelvic fractures ("B‑Type" injuries). During surgery, doctors perform an exam under anesthesia (EUA) that gently stresses the pelvis to see how stable it is. Based on what the exam shows, some patients will not need fixation, some will need fixation in the front (anterior), and others may benefit from fixation in both the front and back (anterior + posterior). When both surgical choices are reasonable, patients will be randomly assigned to one of the two standard options (front only or front + back). Randomization is a fair way to compare treatments that are both commonly used. The goal is to improve recovery and function, reduce complications like loss of alignment or hardware failure, and avoid unnecessary procedures. After surgery (or nonoperative care if no fixation is needed), participants will return for routine clinic visits with X‑rays at about 6 weeks, 3 months, 6 months, and 12 months. At these visits, doctors will check healing and ask participants to complete short questionnaires about their day‑to‑day function and well‑being. All personal information is kept secure. Consent includes an explanation of privacy protections and what participation involves. This study may help future patients by showing when it is safe to use less surgery and when additional stabilization improves outcomes.

H. Claude Sagi, MD

H. Claude Sagi, MD

Trauma

Comparing Two Surgical Approaches for Repairing Posterior Wall Hip Socket Fractures

This study looks at two ways surgeons repair a specific type of hip fracture called a posterior wall acetabular fracture. Both techniques use metal plates to support the bone as it heals. Participants are randomly assigned to one of the two standard surgical treatments and will have regular checkups with X‑rays for up to one year. The goal is to learn whether one method leads to better healing or recovery.

Michael J. Beltran, MD

Michael J. Beltran, MD

Trauma

Comparing Two Surgical Approaches for Fixing Posterior Malleolus Fragments in Ankle Fractures

This study looks at two accepted surgical approaches used to repair a specific part of the ankle-the posterior malleolus-in patients who have trimalleolar ankle fractures. In some patients, surgeons directly fix the broken piece of bone in the back of the ankle. In others, surgeons use indirect techniques to reduce and stabilize the fragment without directly exposing it. Both methods are commonly used today, but it is not known which leads to better stability and long‑term recovery. Patients who require surgery and meet the study's criteria will be invited to participate. Before surgery, each person receives standard X‑rays and a CT scan, and fills out questionnaires about their daily function and overall health. During surgery, after the main ankle bones are fixed, the surgeon performs a series of stress tests on the ankle joint to see whether the syndesmosis-the ligaments between the tibia and fibula-needs to be stabilized. These tests are standard and help determine the best treatment for each patient. The surgery itself and all choices about implants, positioning, and fixation are made by the treating surgeon based on their usual clinical practice. After surgery, patients return for checkups at about 6 weeks, 3 months, 6 months, and 12 months. At these visits, patients complete short surveys about pain, activity, and function, and receive routine X‑rays (except at the initial 2‑week wound check). The goal of the study is to find out whether directly fixing the posterior malleolus fragment leads to better ankle stability, fewer complications, and improved function compared with indirect treatment. The study does not add extra costs, procedures, or risks beyond standard care. What we learn may help guide future treatment decisions and improve recovery for patients with this type of ankle fracture.

Toan T. Le, MD

Toan T. Le, MD

Joints

Phase 3

REGN7508 vs ASA After TKA

This Phase 3 study looks at REGN7508, an experimental drug, compared with aspirin (acetylsalicylic acid) to prevent symptomatic blood clots after elective, one-side total knee replacement in adults. Participants are randomly assigned and neither they nor the study staff know which treatment they receive (double-blind). The main goal is to compare the rate of symptomatic venous thromboembolism (VTE) and VTE-related death up to 30 days after surgery. The study also watches for confirmed deep vein thrombosis (DVT) and pulmonary embolism (PE), time to events, bleeding events, and any side effects up to 90 days. Researchers will measure how much study drug is in the blood over time and check whether participants make antibodies against REGN7508. People with recent major bleeding, certain bleeding disorders, prior clotting disorders, platelet problems, or who received specific pre-op blood thinners are excluded.

Learn More about REGN7508 vs ASA After TKA
Phillip R. Ross, MD

Phillip R. Ross, MD

Hand

Using Ultrasound to Track Median Nerve Recovery After Carpal Tunnel Release Surgery

Carpal tunnel release is a common surgery for relieving pressure on the median nerve in the wrist. While most patients improve, some continue to have symptoms. This study explores whether ultrasound can help track the healing of the median nerve after surgery and whether changes seen on ultrasound relate to how patients feel and function. Ultrasound is quick, painless, and widely available. Before surgery, patients will have an ultrasound exam that measures the size of the median nerve and blood flow within it. These same measurements will be repeated at later follow‑up visits. Researchers will look at whether the nerve becomes smaller, less swollen, or changes in blood flow as healing occurs. Patients also complete simple questionnaires about hand function, symptoms, and daily activities. Doctors will check strength, sensation, and other routine exam findings. By comparing ultrasound images with patient‑reported outcomes, the study aims to learn whether ultrasound could become an easy way to measure recovery after carpal tunnel surgery. All surgeries, exams, and imaging are part of standard care except for the additional research‑guided ultrasound assessments. The information gained may help future patients and doctors better understand the healing process and identify early signs of improvement or persistent problems.

Steven E. Zhang, MD

Spine

How Operating Table Positioning Affects Spine Alignment During Surgery

When patients have spine surgery, they are placed face‑down on special pads that support the chest and pelvis. Small changes in where these pads are positioned may affect the curve and alignment of the spine during surgery. This study aims to find out how much those pad positions matter. Adults having spine surgery with Dr. Zhang may be invited to join. After anesthesia and before surgery begins, three X‑rays of the lower spine and pelvis are taken: one with the pads in the normal position used for surgery, one with the pads shifted slightly upward, and one with the pads shifted slightly downward. Only the normal X‑ray is part of routine care; the other two are performed for the study. After the images are taken, the pads are returned to the normal position and surgery proceeds as planned. Researchers will measure angles in the spine from each X‑ray to see how the position of the pads affects alignment. The goal is to understand whether certain pad placements change the spine's curve and whether these changes could impact surgical planning or outcomes. The study does not change the surgery itself and involves only minimal extra time and two additional X‑rays. All other aspects of care are standard. The information gathered may help surgeons position patients more precisely in the future and improve alignment during spine surgery.

Brian Grawe, MD

Brian Grawe, MD

Sports

Comparing Two Stemless Shoulder Replacement Implants to Improve Function and Patient Outcomes

This study compares two different stemless shoulder replacement implants-the Nano and Sidus components-to learn whether one offers better function, comfort, or recovery for patients needing an anatomic total shoulder arthroplasty (TSA). Both implants are FDA‑approved and routinely used by the surgeon, and the surgery itself follows standard medical practice. Adult patients who are recommended for TSA by Dr. Grawe may be invited to participate. After giving consent, they complete a few short questionnaires about shoulder function and general health, and their range of motion is measured. They are then randomly assigned to receive either the Nano or the Sidus implant. Randomization ensures a fair comparison between the two options. The shoulder replacement surgery is performed in the usual way, with the only difference being the specific stemless implant used. After surgery, patients return for checkups at approximately 6 months, 12 months, and 24 months. At each visit, they complete the same questionnaires and have X‑rays and range of motion testing to evaluate healing and progress. The goal of this research is to determine whether one implant provides better outcomes than the other and to help surgeons choose the best option for future patients. There are no additional procedures, costs, or risks beyond standard care, and both implants represent established shoulder replacement options already widely used in clinical practice.

Michael J. Beltran, MD

Michael J. Beltran, MD

Trauma | Joints

FASTER-HIP: Studying the Best Surgery for Certain Hip Fractures

FASTER-HIP is a research study comparing two common surgeries for certain hip fractures in older adults. The goal is to find out which surgery leads to better recovery, fewer complications, and helps patients stay active and independent.

H. Claude Sagi, MD

H. Claude Sagi, MD

Trauma

Continuous Passive Motion After Fixation

This study will test whether using a continuous passive motion (CPM) machine after surgery helps control pain and reduce narcotic use in people who had surgery to fix certain pelvis or knee fractures. Adults with an isolated acetabular fracture, supracondylar femur fracture, or tibial plateau fracture who have had surgery will be asked to join. Participants are randomized to either a CPM plus usual physical therapy or usual care with physical therapy alone. The CPM is started after surgery and used while the patient is awake in bed for two hours on and two hours off when not working with physical therapy. Nurses and therapists will record daily pain scores and track pain medications during the hospital stay. Incisions will be checked daily and any problems will be monitored. At one year, participants will complete standard functional surveys to compare recovery. Data are recorded in the electronic health record.

Learn More about Continuous Passive Motion After Fixation
Matt M. Florczynski, MD

Matt M. Florczynski, MD

Hand

Comparing Surgical Options for Treating Recurrent Carpal Tunnel Symptoms After a Prior Release

This study compares three different surgical approaches used when carpal tunnel symptoms return after a previous surgery. Some people experience relief at first, but symptoms later come back, and doctors must decide which type of revision surgery will give the best results. Because there is not enough research comparing these options, this study is designed to help provide clearer answers. Adults who have recurrent carpal tunnel symptoms and have tried nonsurgical treatments such as splinting or injections may qualify to participate. After completing a baseline evaluation, including hand strength testing and questionnaires, participants are randomly assigned to one of three revision procedures. All three techniques are currently used in clinical practice. After surgery, participants will return for follow‑up visits at several points over two years. At each visit they will complete surveys and have simple hand function checks to track improvement in symptoms, comfort, and daily use of the hand. By comparing recovery, hand function, and symptom improvement across different revision procedures, the study aims to help surgeons choose the best option for future patients. The study also looks at whether pre‑surgery symptoms, nerve test results, or imaging findings can help predict how well someone will recover after revision surgery.

Michael J. Beltran, MD

Michael J. Beltran, MD

Trauma

Bead Pouch versus Wound VAC Trial

This trial will enroll 312 adults with severe open fractures of the tibia who need more than one surgical washout (irrigation and debridement). Participants are randomly assigned to one of two temporary wound treatments used between surgeries: an antibiotic cement bead pouch (beads placed in the wound and sealed with an occlusive dressing) or negative pressure wound therapy (NPWT or Wound VAC). The assigned treatment is given at the end of the first washout surgery. Patients are followed at about 6 weeks, 3 months, and 6 months. The main goal is to see which treatment leads to fewer serious problems by 6 months, using a ranked composite outcome that looks first at death, then at injury related amputation, then at unplanned reoperations for wound or healing problems, and finally at clinical fracture healing measured by a standard trauma function tool. Secondary analyses look at each of those outcomes separately. Safety and outcome events will be reviewed by independent committees.

Learn More about Bead Pouch versus Wound VAC Trial
Brian Grawe, MD

Brian Grawe, MD

Sports

Understanding Patient Outcomes and Recovery After Shoulder Injuries Treated at UC Orthopaedics

This study is designed to help doctors better understand how people recover from shoulder injuries and what factors influence long‑term outcomes. Researchers will look at past medical records of patients who were treated for shoulder injuries at UC Orthopaedics, whether they had surgery or were treated without an operation. Information such as age, type of injury, treatment received, and follow‑up care will be reviewed to learn more about how different patients recover. Patients will also be asked to complete short surveys that describe their pain levels, shoulder function, and how their injury affects their daily life. These surveys are widely used in orthopedics to understand a patient's overall well‑being and recovery progress. Completion can be done from home using a phone or computer. In addition, patients will have the option to return to clinic for a free shoulder exam performed by an orthopedic provider. This physical exam helps measure strength, movement, and overall shoulder function, giving researchers a more complete picture of recovery. By combining information from medical records, patient surveys, and optional physical exams, this study aims to identify trends in recovery and help doctors provide better care for future patients with shoulder injuries.

Brian Grawe, MD

Brian Grawe, MD

Sports

Phase 3

Testing ZILRETTA for Shoulder Osteoarthritis Pain Relief

This study is checking whether a medication called ZILRETTA helps with shoulder pain caused by osteoarthritis, compared to a saltwater injection (placebo) and another medication (TCA-IR). People taking part need to have shoulder osteoarthritis and be between 50 and 80 years old. They will get either ZILRETTA, TCA-IR, or a placebo shot in the arm. Doctors will follow up with them for several months to see how the pain changes and ensure safety. Up to 250 people will join, and their experiences with pain and any side effects will be closely monitored through regular check-ups and diaries. The main goal is to see if ZILRETTA can really help reduce pain better than the other treatments.

Learn More about Testing ZILRETTA for Shoulder Osteoarthritis Pain Relief
Michael J. Beltran, MD

Michael J. Beltran, MD

Trauma

Comparing Surgical vs Nonsurgical Care for Fragility Pelvic Fractures: The FLIPER Pilot Study

Fragility fractures of the pelvis are increasing as the population ages. Doctors often treat these injuries either with surgery or with nonsurgical care focused on early movement and rehabilitation. It is not yet clear which option works best for which patients, and previous studies have had limitations. The FLIPER pilot study is designed to prepare for a larger, more definitive study by testing whether it's practical to compare these treatments fairly and safely. People aged 60 and older with a specific type of low‑energy pelvic fracture (LC1) may be eligible. After consent, the research team collects information from the hospital chart and from the patient or a family member. The care team decides whether surgery or nonsurgical care is best, based on their usual clinical judgment. About four months after the injury, participants (or their caregivers) are contacted to see how they are doing. The study focuses on three important outcomes at about four months: Survival (whether the patient is still living), Ability to walk across a room, and "Days at home," meaning the number of days not spent in a hospital or facility. The team will also ask patients and surgeons if they would be willing to take part in a future randomized study that directly compares surgery to nonsurgical care. This helps researchers learn whether a larger trial would be acceptable and realistic. No experimental treatments are involved. All care decisions are made by the medical team as part of normal practice. The information learned from this pilot will guide the design of a larger study to improve treatment decisions and outcomes for older adults with fragility pelvic fractures.

Richard T. Laughlin, MD

Richard T. Laughlin, MD

Foot and Ankle

Evaluating Recovery After Staged Fusion Procedures for Hindfoot Infections and Nonunions

This study is looking at how people recover after having staged surgery to treat an infected hindfoot nonunion, a serious condition where the bones in the back of the foot fail to heal and become infected. Treatment often requires multiple surgeries and long recovery periods. By reviewing past medical records and asking patients to complete short surveys, the research team hopes to better understand what recovery looks like after this type of complex foot and ankle surgery. Researchers will review information already in the patient's medical record, such as age, injury type, medical history, treatments received, and any complications. Patients who are willing to participate will be contacted by phone or email and asked to complete surveys about their pain, mobility, daily functioning, and overall well‑being. These surveys are commonly used in orthopedics to understand patient recovery and quality of life after surgery. By learning more about patients' experiences and long‑term outcomes, the study aims to improve future care for people facing similar infections and nonhealing injuries in the foot and ankle.

Brian Grawe, MD

Brian Grawe, MD

Sports

Comparing Two Stemless Shoulder Replacement Implants to Improve Function and Patient Recovery

This study compares two different stemless shoulder replacement implants-the Nano and Osseofit components-to determine whether one leads to better function, less pain, or easier recovery for patients undergoing anatomic total shoulder arthroplasty (TSA). Both implants are commonly used and part of normal surgical practice. Adults recommended for TSA by Dr. Grawe may be invited to participate. Once patients agree to join the study, they complete short surveys about arm and shoulder function and overall health. Their shoulder range of motion is also measured. They are then randomly assigned to receive either the Nano or the Osseofit implant during their standard shoulder replacement surgery. After surgery, patients return for routine follow‑up visits at around 6 months, 12 months, and 24 months. At each visit, they complete the same questionnaires, have their shoulder examined, and receive X‑rays. This helps the research team understand how well each implant works over time. The purpose of the study is to learn whether one stemless implant provides better outcomes, quicker recovery, or improved function. Both devices are FDA‑approved, widely used, and safe, and no part of the study involves experimental treatments. The results may help guide future patients and surgeons in choosing the most effective option for shoulder replacement.

H. Claude Sagi, MD

H. Claude Sagi, MD

Trauma

Comparing Two Surgical Methods to Help Tibia Fractures Heal: Internal Compression vs Backslapping

This study is comparing two common ways surgeons help a broken shinbone (tibia) heal after placing a metal rod inside the bone. One method uses a technique called "backslapping" that allows small movements at the screw holes (dynamic locking). The other method uses the rod to gently squeeze the fracture together (internal compression) and then holds it firmly (static locking). Both methods are standard and use approved implants. Adults with a straight‑across tibia fracture may qualify. Participants are randomly assigned to one of the two methods. Everyone may put full weight on the leg right after surgery unless the treating team advises otherwise for safety. Patients return for checkups with X‑rays at around 6, 12, 24, and 52 weeks so the team can measure healing and any complications. The study's main goal is to learn which method leads to faster and more reliable bone healing and to understand any differences in risks like implant breakage, infection, or the need for additional procedures. What we learn may help future patients and surgeons choose the approach that offers the best chance of strong, timely healing.

Brian Grawe, MD

Brian Grawe, MD

Sports

Phase 3

CARTISTEM Debridement Knee Trial

This is a randomized, double-blind Phase 3 trial testing CARTISTEM against standard surgical debridement in adults with a moderate knee cartilage defect and knee osteoarthritis. CARTISTEM is a treatment made from donated umbilical cord blood stem cells mixed into a gel that is placed into the cartilage defect during surgery. Participants will be randomly assigned to receive CARTISTEM or debridement and will be followed for 24 months. The main goals are to see whether CARTISTEM reduces pain (measured by a 0–100 pain scale) and improves knee function (WOMAC function score) more than debridement at two years. The study will also use MRI scans to look at cartilage repair and osteoarthritis changes. People must meet health and imaging requirements and agree to the study rules and rehabilitation program to take part.

Learn More about CARTISTEM Debridement Knee Trial
Toan T. Le, MD

Toan T. Le, MD

Joints

Phase 2

PLG0206 to Prevent Knee PJI Recurrence

This study tests whether a single irrigation of the investigational drug PLG0206, given during a DAIR surgery for an infected knee replacement, can reduce infection recurrence and is safe. People who qualify will have the usual DAIR surgery at their hospital. After cleaning the joint, the study drug or a matching placebo will be given as one final wash inside the knee. All participants will receive standard post-operative care, including any antibiotics their doctors order. Participants will be followed for about 12 months to watch for return or persistence of infection, any surgeries needed later, safety problems, knee function, and blood tests. Follow-up includes clinic visits and phone or virtual check-ins at set times over the year. The main goal is to compare how many people in each group have treatment failure (infection return) within 12 months.

Learn More about PLG0206 to Prevent Knee PJI Recurrence
Brian Grawe, MD

Brian Grawe, MD

Sports

Studying Shoulder Replacement Outcomes Using a Custom Baseplate for Severe Glenoid Bone Loss

This study looks at how well people do after a reverse shoulder replacement when they have severe bone loss in the socket of the shoulder (the glenoid). In these cases, a standard implant may not fit securely, so surgeons use a custom‑designed baseplate created from each patient's CT scan. The goal is to better understand early recovery, function, and implant stability in patients who receive these individualized implants. Patients who had this surgery between 2021 and 2024 and are willing to participate will be included. The study collects information from past medical records and from a new clinic visit. During this visit, patients complete short questionnaires about shoulder function and pain and undergo a routine exam that measures how far the shoulder can move. Patients also receive a CT scan so researchers can check how stable the baseplate is and whether screws or components have shifted. All surgeries were already completed as part of normal medical care. The study does not involve any new procedures, additional surgery, or experimental treatments. The custom baseplates used were designed from CT imaging to match each patient's anatomy and were implanted by a shoulder specialist. The information gathered will help surgeons understand how well these custom implants perform in the first months after surgery and whether they offer advantages for people with major glenoid bone loss. Findings may guide future treatment decisions and improve the quality of care for shoulder replacement patients with complex anatomy.