Office of Research
Clinical Trials

Leading the Future of Clinical Medicine
The College of Medicine is a hub for groundbreaking clinical research. With over 30 specialized research units, our teams are dedicated to translating laboratory discoveries into life-saving clinical applications. From neurology to oncology, we provide the infrastructure and expertise necessary to push the boundaries of modern medicine.

Browse our Research Units below to view current study listings.

Clinical Trials Search

Jordan Kharofa, MD

Jordan Kharofa, MD

Gastrointestinal Cancer

Phase 3

Higher Dose Radiation Therapy for Advanced Pancreatic Cancer Trial

This study is exploring if giving higher doses of radiation can help people with advanced pancreatic cancer live longer. Participants must have already undergone 4-6 months of chemotherapy and have stable disease without progression. There are two groups in the study. One group will receive standard treatment, which could include continuing chemotherapy, a normal dose of radiation, or observation. The other group will receive higher doses of radiation over a shorter period to see if it prolongs their survival. Patients will have regular follow-ups and will be checked through blood tests, imaging scans, and tissue biopsies. They are monitored over a period that includes every three-month checkups for two years and then yearly for another three years. This study aims to not only see if survival improves but examine side effects, quality of life, and any changes in disease progression.

This study may be appropriate for those with: Metastatic Cancer

Learn More about Higher Dose Radiation Therapy for Advanced Pancreatic Cancer Trial
Davendra Sohal, MD, MPH

Davendra Sohal, MD, MPH

Gastrointestinal Cancer

Testing the Use of Chemotherapy After Surgery for High-Risk Pancreatic Neuroendocrine Tumors

This phase II trial studies the effect of capecitabine and temozolomide after surgery in treating patients with high-risk well-differentiated pancreatic neuroendocrine tumors. Chemotherapy drugs, such as capecitabine and temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving capecitabine and temozolomide after surgery could prevent or delay the return of cancer in patients with high-risk well-differentiated pancreatic neuroendocrine tumors.

This study may be appropriate for those with: Newly Diagnosed Cancer

Learn More about Testing the Use of Chemotherapy After Surgery for High-Risk Pancreatic Neuroendocrine Tumors
Davendra Sohal, MD, MPH

Davendra Sohal, MD, MPH

Gastrointestinal Cancer

Phase 2

Efficacy and Safety of Adjuvant in Patients With Resected Pancreatic Ductal Adenocarcinoma

This study is evaluating an experimental drug called autogene cevumeran in patients with pancreatic ductal adenocarcinoma that has been resected (surgically removed). The goal is to find out whether combining these newer therapies (atezolizumab and autogene cevumeran) with standard chemotherapy is safe and more effective at reducing the risk of cancer returning compared to chemotherapy alone.

This study may be appropriate for those with: Newly Diagnosed Cancer

Learn More about Efficacy and Safety of Adjuvant in Patients With Resected Pancreatic Ductal Adenocarcinoma
Davendra Sohal, MD, MPH

Davendra Sohal, MD, MPH

Phase 1 - Solid Tumor | Gastrointestinal Cancer

CA-4948 Added to Standard Chemotherapy to Treat Metastatic or Unresectable Pancreatic Cancer

The usual approach for patients with pancreatic ductal adenocarcinoma is treatment with chemotherapy drugs gemcitabine and nab-paclitaxel. Gemcitabine is a chemotherapy drug that blocks the cells from making DNA and may kill cancer cells. Paclitaxel is in a class of medications called anti-microtubule agents. It stops cancer cells from growing and dividing and may kill them. Nab-paclitaxel is an albumin-stabilized nanoparticle formulation of paclitaxel which may have fewer side effects and work better than other forms of paclitaxel. Giving CA-4948 in combination with gemcitabine and nab-paclitaxel may shrink or stabilize metastatic or unresectable pancreatic ductal adenocarcinoma.

This study may be appropriate for those with: Metastatic Cancer

Learn More about CA-4948 Added to Standard Chemotherapy to Treat Metastatic or Unresectable Pancreatic Cancer
Davendra Sohal, MD, MPH

Davendra Sohal, MD, MPH

Phase 1 - Solid Tumor

Phase 1

Testing LY3962673 in KRAS G12D-Mutant Solid Tumors

This study is examining a new drug, LY3962673, which aims to treat certain types of advanced cancer that have a specific mutation known as KRAS G12D. These cancers include pancreatic, lung, and colorectal cancers. The study is testing how safe LY3962673 is when used alone and in combination with other chemotherapy drugs, as well as how well it works in reducing tumor size. It will last about five years, and participants will undergo various assessments to track their response to the treatment. The study hopes to determine both the best way to use the drug and its effectiveness over time. Participants who previously had treatments that didn't fully work for these specific cancers might qualify.

This study may be appropriate for those with: Metastatic Cancer

Learn More about Testing LY3962673 in KRAS G12D-Mutant Solid Tumors
Davendra Sohal, MD, MPH

Davendra Sohal, MD, MPH

Gastrointestinal Cancer

Phase 1

Study of RAS Inhibitors in GI Tumors

This clinical study is investigating new drugs called RAS inhibitors for treating gastrointestinal cancers, focusing mainly on colorectal and pancreatic cancers. The goal is to see if these drugs are safe, how well they are tolerated by patients, and if they show any early signs of fighting the cancer. Researchers are combining these RAS inhibitors with standard cancer treatments or other new drugs to find the most effective therapy. The study has three main parts, each testing a different combination of drugs: 1. **Part A**: This part looks at RMC-6236 combined with 5-fluorouracil-based treatments in patients who have not received prior treatment for their unresectable or metastatic colorectal cancer or metastatic pancreatic cancer. 2. **Part B**: In this segment, RMC-6236 is paired with cetuximab, and sometimes with mFOLFOX6, for patients with unresectable or metastatic colorectal cancer or those who have either previously treated or newly diagnosed metastatic pancreatic cancer. 3. **Part C**: This section tests RMC-6236 combined with gemcitabine and nab-paclitaxel in patients who have newly diagnosed metastatic pancreatic cancer. Each part of the study is open-label, meaning that both the doctors and the patients know which treatments are being given. The study consists of two phases: Dose Exploration to find the right dose levels and Dose Expansion to further evaluate the selected doses. To join the study, participants must be adults with specific types of cancer and good overall health. They should not have had major surgery 28 days before starting the study, and cannot have certain health issues like primary CNS tumors or GI problems that might affect the drug's absorption. The main outcomes of the study include monitoring for adverse events, understanding how the drug moves through the body, and measuring how well the drug works against the cancer. These measurements will include looking at how long and how well patients respond to the treatment, how long they live without the cancer getting worse, and their overall survival time. The study is currently recruiting participants and holds promise for finding more effective treatments for GI cancers involving mutations in the RAS gene.

This study may be appropriate for those with: Metastatic Cancer

Learn More about Study of RAS Inhibitors in GI Tumors
Davendra Sohal, MD, MPH

Davendra Sohal, MD, MPH

Gastrointestinal Cancer

Phase 2

Relacorilant With Chemo for Pancreas

This is a Phase 2, single-arm study testing relacorilant combined with standard chemotherapy (nab-paclitaxel and gemcitabine) in people with newly diagnosed metastatic pancreatic ductal adenocarcinoma. Participants take relacorilant by mouth around the days they receive chemotherapy. Chemotherapy infusions are given on Days 1, 8, and 15 of each 28-day cycle. Treatment continues until the cancer gets worse, side effects cannot be managed, or another stopping reason occurs. The study will measure how long patients live without cancer growth, overall survival, tumor responses, changes in a tumor blood marker (CA19-9), safety, and drug levels in the blood.

This study may be appropriate for those with: Metastatic Cancer

Learn More about Relacorilant With Chemo for Pancreas
Olugbenga Olowokure, MD

Olugbenga Olowokure, MD

Gastrointestinal Cancer

Phase 3

Panitumumab for KRAS Wild Type Pancreas

This is a phase III randomized trial for adults with pancreatic ductal adenocarcinoma that cannot be removed by surgery or that has spread, whose tumors are KRAS wild type and BRAF V600E wild type by tissue testing. Participants are assigned to one of two groups. One group receives standard second line chemotherapy (one of several standard regimens) alone. The other group receives the same chemotherapy plus panitumumab, an antibody that targets EGFR on tumor cells. Treatment is given in 28 day cycles, typically with drug infusions on days 1 and 15, and continues until the cancer progresses or side effects are unacceptable. The main goal is to see whether adding panitumumab improves overall survival. The study also compares tumor response, progression free survival, side effects, and quality of life. Blood and tumor samples may be collected and stored for future research. Participants are followed for up to three years after randomization.

This study may be appropriate for those with: Metastatic Cancer

Learn More about Panitumumab for KRAS Wild Type Pancreas
Davendra Sohal, MD, MPH

Davendra Sohal, MD, MPH

Phase 1 - Solid Tumor

Phase 1

Study of PF-07934040 for Advanced Tumors with KRAS Gene Mutations

This clinical study is testing a new cancer medicine called PF-07934040. The study focuses on people with advanced solid tumors, which are cancers that don't go away or stay away after treatment. These tumors have a specific genetic mutation in the KRAS gene, which can make cancer cells grow quickly. The study includes people with types of cancer such as non-small cell lung cancer (NSCLC), colorectal cancer (CRC), and pancreatic ductal adenocarcinoma (PDAC). The study is in Phase 1, meaning it's looking at how safe the medicine is and what effects it has. Researchers also want to find the best dose to give to patients. The medicine can be taken alone or with other cancer treatments. Participants will take PF-07934040 as a pill twice a day in cycles of either 21 or 28 days. Those who are also getting other treatments will have those given by IV at the clinic. The study will last up to four years, with participants visiting the clinic 1 to 4 times every cycle. They can continue the treatment as long as it helps control their cancer. After stopping the medicine (usually around two years), they will be followed for two more years to check on their health. To join the study, participants must have a KRAS gene mutation and show that their cancer has not responded to standard treatments. They must also have a good level of daily functioning and at least one measurable tumor that has not been treated with radiation. There are also specific criteria for different cancer types, such as the number of previous treatments. People cannot join if they have certain health problems, like lung diseases that need steroids, immune system issues, or severe nerve damage. They also can't participate if they've had major surgery or radiation therapy recently, or if they have allergies to the study treatments. The study aims to learn if PF-07934040 is safe and effective in treating these advanced cancers. It will measure safety through any side effects and lab test changes. It will also look at how many participants respond to the treatment, how long it takes for the medicine to reach its peak in the body, and how long it stays there.

This study may be appropriate for those with: Relapsed / Refractory Cancer

Learn More about Study of PF-07934040 for Advanced Tumors with KRAS Gene Mutations