Leading the Future of Clinical Medicine
The College of Medicine is a hub for groundbreaking clinical research. With over 30 specialized research units, our teams are dedicated to translating laboratory discoveries into life-saving clinical applications. From neurology to oncology, we provide the infrastructure and expertise necessary to push the boundaries of modern medicine.
Browse our Research Units below to view current study listings.
Greg R. Dion, MD
Laryngology
Adults having airway surgery may allow small cell samples to be collected and grown in the lab. This research helps scientists study airway diseases and test new treatments but does not change patient care.
Ahmad R. Sedaghat, MD
Rhinology
This research aims to learn more about conditions that cause long-lasting sinus and nasal inflammation, such as chronic sinusitis and allergies. People already receiving routine care may be asked to provide small samples of nasal mucus, blood, or tissue during regular clinic visits. Researchers will compare these samples with symptoms and treatment results over time to understand why some patients respond better to medical treatments than others. The goal is to support more personalized care in the future.
Brittany N. Krekeler, PHD,CCC-SLP
Dysphagia Rehab
Healthy adults complete swallowing and tongue exercises during a single x-ray swallow study visit. The goal is to understand how these exercises move swallowing muscles.
Katie M. Phillips, MD
Rhinology
This study aims to understand why people with chronic sinus problems sometimes experience sudden flare-ups. Adults with chronic sinusitis will have nasal samples taken during a flare-up and again about a month later. The study does not change medical care but may help improve future treatments.
Greg R. Dion, MD
Laryngology
Adults undergoing airway surgery will have airway samples collected to study bacteria that may affect healing and disease.
Brittany N. Krekeler, PHD,CCC-SLP
Dysphagia Rehab
This study will use videofluoroscopy (a moving X-ray of swallowing) to measure how people of different ages swallow. The team will test about 280 healthy adults across the adult age span and will also collect data from three clinical groups at risk for swallowing problems: people with Parkinson disease, people with COPD, and people recently having had a stroke. The goal is to build clear normal ranges for swallowing measures (like airway protection, residue left after swallowing, timing of airway closure, and how well the throat squeezes) and to find practical cutoff points that help tell normal from disordered swallowing. The results aim to help clinicians interpret swallowing tests more reliably and guide diagnosis and treatment decisions.
Daniel Q. Sun, MD
Otology
During routine ear surgery, small pieces of tissue that would otherwise be thrown away are studied in the lab to improve future hearing treatments.
Brittany N. Krekeler, PHD,CCC-SLP
Dysphagia Rehab
This study is exploring how eating a normal meal may cause tongue fatigue and whether this differs by age. Healthy younger and older adults will complete simple tongue strength tasks before and after eating a standardized meal. These tasks help researchers understand how eating affects the muscles used for chewing and swallowing. Participation involves a single visit and does not change medical care. The results may help improve understanding of fatigue related to eating as people age.
Katie M. Phillips, MD
Rhinology
Adults having sinus surgery will receive either standard or improved written instructions. About one week later, they will answer questions about how helpful and clear the instructions were.
Katie M. Phillips, MD
Rhinology
Adults with chronic sinusitis undergoing sinus surgery may have discarded tissue studied to understand different biological patterns of the disease.
Katie M. Phillips, MD
Rhinology
Adults having sinus surgery may join this study, which compares disease patterns across different groups. Participation involves data collection around routine care.
Ahmad R. Sedaghat, MD
Rhinology
This study aims to better understand how people with chronic sinus problems think about when their symptoms are "under control" and what they consider a flare-up. Adults with chronic sinus disease will be asked to share their experiences during interviews, either by phone, video, or in clinic. Researchers will look for common themes in these conversations to help create clearer, patient-centered ways for doctors and patients to talk about symptoms and treatment success. Participation involves interviews only and does not change medical care.
Brittany N. Krekeler, PHD,CCC-SLP
Dysphagia Rehab
Adults having a routine swallow x-ray can join a brief tongue strength test to see how tongue function relates to swallowing.
Ahmad R. Sedaghat, MD
Rhinology
This study interviews adults with chronic sinus problems to understand how they recognize flare-ups and symptom control. The goal is to improve future symptom tracking and care.
Ahmad R. Sedaghat, MD
Rhinology
Adults having sinus surgery may provide samples to help researchers understand inflammation and improve treatments.
Daniel Q. Sun, MD
Otology
Adults undergoing ear surgery may allow discarded tissue to be studied in the lab to improve future drug delivery to the ear.
Greg R. Dion, MD
Laryngology
Adults will have brief ultrasound scans of the neck to help train a computer system to recognize airway structures, which may aid future emergency care.
Katie M. Phillips, MD
Rhinology
Phase 3
This Phase 3 study will test itepekimab, a laboratory-made antibody that targets IL-33, in adults with chronic rhinosinusitis and nasal polyps that are not well controlled by standard care. Participants will continue intranasal corticosteroid spray and be randomly assigned to one of two itepekimab dose schedules or to placebo. The trial is double-blind and runs up to 52 weeks of treatment with screening before and safety follow-up after. Main goals are to see if itepekimab reduces polyp size and nasal congestion by 24 weeks, and to assess benefits through 52 weeks including sense of smell, CT scan changes, quality of life, lung function in those with asthma, and whether fewer people need steroid courses or sinus surgery. Safety will be monitored throughout, including adverse events and immune responses to the drug. Each participant will have about 9 site visits plus 20 phone or home contacts over the study period.
Greg R. Dion, MD
Laryngology | Head and Neck Cancer
This study looks at how the bacteria in the mouth and throat change for people having surgery for head and neck cancer. Some patients receive a free flap, which means tissue is moved from another part of the body to help with reconstruction. Others have surgery without a free flap. Participants provide simple swab samples before surgery and again about six weeks after surgery. These samples help researchers learn how surgery affects the natural bacteria in the mouth and throat. The study does not provide direct medical benefit, but what we learn may help improve future cancer care
Aaron Friedman, MD
Laryngology
This study looks at growths in the voice box and airway caused by a virus. When adults have planned procedures to treat these growths, a small amount of tissue (and sometimes blood) is collected and used to grow cells in the lab. Researchers study the virus and genes and test different medicines on the lab grown cells to see what works best. There are no extra study visits. Participation continues while a person receives usual care. The main risk is a privacy breach, and steps are taken to protect information. Results are not shared with participants. About 50 adults are expected to take part.
Rebecca J. Howell, MD
Laryngology
Adults with and without vocal fold paralysis will take part during a standard swallowing test. Researchers will record how the voice box moves during swallowing and speaking to better understand swallowing safety. There is no direct benefit to participants.
Rebecca J. Howell, MD
Laryngology
Adults having surgery for a weak or paralyzed vocal cord will have their recovery tracked over time through routine follow-up visits and questionnaires. The study helps improve future care.
Greg R. Dion, MD
Laryngology
Adults who have had their voice box removed and use a voice prosthesis may join during a regular clinic visit. A special camera is added briefly to the routine exam to record how tissues vibrate to create voice. The study does not change care and offers no direct benefit.
Aaron Friedman, MD
Laryngology
Phase 3
This study is testing a vaccine for adults with repeated airway growths that often need surgery. Participants receive four vaccine injections and are followed to see if surgery is needed less often and if symptoms improve.
Greg R. Dion, MD
Laryngology
Adults already undergoing voice-related surgery may allow unused fat tissue to be studied. No extra procedures are added, and care is unchanged.
Daniel Q. Sun, MD
Otology
Adults receiving cochlear implants will have their hearing and quality of life followed over time to improve future care.
Brittany N. Krekeler, PHD,CCC-SLP
Dysphagia Rehab
Adults aged 50 or older referred for a swallow test may participate in a study using ultrasound alongside standard X-ray tests. Some may also try ultrasound feedback during therapy.
Rebecca J. Howell, MD
Laryngology
Adults with normal or swallowing problems will have ultrasound imaging during swallowing tasks to better understand how the tongue and throat move. This may improve future swallowing evaluations.
Alice Tang, MD
Head and Neck Cancer
Women who have had surgery for head and neck cancer are invited to share their experiences in a one-time interview. The goal is to better understand emotional, social, and daily life impacts after treatment.
Daniel Q. Sun, MD
Otology
Adults with and without hearing loss will undergo MRI scans to study brain changes related to hearing.
Brittany N. Krekeler, PHD,CCC-SLP
Dysphagia Rehab
Healthy adults will undergo ultrasound imaging while swallowing to establish normal movement patterns.
Aaron Friedman, MD
Laryngology
Adults with recurrent respiratory papillomas will track their voice using surveys and a mobile app over time to understand how treatments affect voice quality.
Daniel Q. Sun, MD
Otology
Adults with hearing loss in one ear answer surveys about their hearing device, how often they use it, and how it affects daily life. Participation involves questionnaires by phone or in clinic.
Brittany N. Krekeler, PHD,CCC-SLP
Dysphagia Rehab
Adults who have swallowing problems after stroke will perform tongue exercises or a comparison activity. Swallowing tests before and after help determine if exercises improve function.
