Raphael Kopan, Ph.D., PhD

Demitrack, Elise S; Gifford, Gail B; Keeley, Theresa M; Carulli, Alexis J; VanDussen, Kelli L; Thomas, Dafydd; Giordano, Thomas J; Liu, Zhenyi; Kopan, Raphael; Samuelson, Linda C 2015. Notch signaling regulates gastric antral LGR5 stem cell function. The EMBO journal, 34 20, 2522-36

Hass, Matthew R; Liow, Hien-Haw; Chen, Xiaoting; Sharma, Ankur; Inoue, Yukiko U; Inoue, Takayoshi; Reeb, Ashley; Martens, Andrew; Fulbright, Mary; Raju, Saravanan; Stevens, Michael; Boyle, Scott; Park, Joo-Seop; Weirauch, Matthew T; Brent, Michael R; Kopan, Raphael 2015. SpDamID: Marking DNA Bound by Protein Complexes Identifies Notch-Dimer Responsive Enhancers. Molecular cell, 59 4, 685-97

Liu, Zhenyi; Brunskill, Eric; Boyle, Scott; Chen, Shuang; Turkoz, Mustafa; Guo, Yuxuan; Grant, Rachel; Kopan, Raphael 2015. Second-generation Notch1 activity-trap mouse line (N1IP::CreHI) provides a more comprehensive map of cells experiencing Notch1 activity. Development (Cambridge, England), 142 6, 1193-202

Liu, Zhenyi; Brunskill, Eric; Varnum-Finney, Barbara; Zhang, Chi; Zhang, Andrew; Jay, Patrick Y; Bernstein, Irv; Morimoto, Mitsuru; Kopan, Raphael 2015. The intracellular domains of Notch1 and Notch2 are functionally equivalent during development and carcinogenesis. Development (Cambridge, England), 142 14, 2452-63

Liu, Zhenyi; Schneider, Daniel L; Kornfeld, Kerry; Kopan, Raphael 2015. Corrigendum: Simple Copy Number Determination with Reference Query Pyrosequencing (RQPS). Cold Spring Harbor protocols, 2015 10, pdb.corr090167

Boyle, Scott C; Liu, Zhenyi; Kopan, Raphael 2014. Notch signaling is required for the formation of mesangial cells from a stromal mesenchyme precursor during kidney development. Development (Cambridge, England), 141 2, 346-54

Ilagan, Ma Xenia G; Kopan, Raphael 2014. Monitoring Notch activation in cultured mammalian cells: luciferase complementation imaging assays. Methods in molecular biology (Clifton, N.J.), 1187 , 155-68

Ilagan, Ma Xenia G; Kopan, Raphael 2014. Monitoring Notch activation in cultured mammalian cells: transcriptional reporter assays. Methods in molecular biology (Clifton, N.J.), 1187 , 143-54

Kopan, Raphael; Chen, Shuang; Little, Melissa 2014. Nephron progenitor cells: shifting the balance of self-renewal and differentiation. Current topics in developmental biology, 107 , 293-331

Kopan, Raphael; Chen, Shuang; Liu, Zhenyi 2014. Alagille, Notch, and robustness: why duplicating systems does not ensure redundancy. Pediatric nephrology (Berlin, Germany), 29 4, 651-7

Chillakuri, Chandramouli R; Sheppard, Devon; Ilagan, Ma Xenia G; Holt, Laurie R; Abbott, Felicity; Liang, Shaoyan; Kopan, Raphael; Handford, Penny A; Lea, Susan M 2013. Structural analysis uncovers lipid-binding properties of Notch ligands. Cell reports, 5 4, 861-7

Groot, Arjan J; Cobzaru, Cristina; Weber, Silvio; Saftig, Paul; Blobel, Carl P; Kopan, Raphael; Vooijs, Marc; Franzke, Claus-Werner 2013. Epidermal ADAM17 is dispensable for notch activation. The Journal of investigative dermatology, 133 9, 2286-8

Ilagan, Ma Xenia G; Kopan, Raphael 2013. Selective blockade of transport via SERCA inhibition: the answer for oncogenic forms of Notch? Cancer cell, 23 3, 267-9

Liu, Zhenyi; Chen, Shuang; Boyle, Scott; Zhu, Yu; Zhang, Andrew; Piwnica-Worms, David R; Ilagan, Ma Xenia G; Kopan, Raphael 2013. The extracellular domain of Notch2 increases its cell-surface abundance and ligand responsiveness during kidney development. Developmental cell, 25 6, 585-98

Liu, Zhiyong; Liu, Zhenyi; Walters, Bradley J; Owen, Thomas; Kopan, Raphael; Zuo, Jian 2013. In vivo visualization of Notch1 proteolysis reveals the heterogeneity of Notch1 signaling activity in the mouse cochlea. PloS one, 8 5, e64903

Satpathy, Ansuman T; Briseño, Carlos G; Lee, Jacob S; Ng, Dennis; Manieri, Nicholas A; Kc, Wumesh; Wu, Xiaodi; Thomas, Stephanie R; Lee, Wan-Ling; Turkoz, Mustafa; McDonald, Keely G; Meredith, Matthew M; Song, Christina; Guidos, Cynthia J; Newberry, Rodney D; Ouyang, Wenjun; Murphy, Theresa L; Stappenbeck, Thaddeus S; Gommerman, Jennifer L; Nussenzweig, Michel C; Colonna, Marco; Kopan, Raphael; Murphy, Kenneth M 2013. Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens. Nature immunology, 14 9, 937-48

Yockey, Laura J; Demehri, Shadmehr; Turkoz, Mustafa; Turkoz, Ahu; Ahern, Philip P; Jassim, Omar; Manivasagam, Sindhu; Kearney, John F; Gordon, Jeffrey I; Kopan, Raphael 2013. The absence of a microbiota enhances TSLP expression in mice with defective skin barrier but does not affect the severity of their allergic inflammation. The Journal of investigative dermatology, 133 12, 2714-21

Zhao, Zhong-Qiu; Huo, Fu-Quan; Jeffry, Joseph; Hampton, Lori; Demehri, Shadmehr; Kim, Seungil; Liu, Xian-Yu; Barry, Devin M; Wan, Li; Liu, Zhong-Chun; Li, Hui; Turkoz, Ahu; Ma, Kaijie; Cornelius, Lynn A; Kopan, Raphael; Battey, James F; Zhong, Jian; Chen, Zhou-Feng 2013. Chronic itch development in sensory neurons requires BRAF signaling pathways. The Journal of clinical investigation, 123 11, 4769-80

Barak, Hila; Huh, Sung-Ho; Chen, Shuang; Jeanpierre, Cécile; Martinovic, Jelena; Parisot, Mélanie; Bole-Feysot, Christine; Nitschké, Patrick; Salomon, Rémi; Antignac, Corinne; Ornitz, David M; Kopan, Raphael 2012. FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man. Developmental cell, 22 6, 1191-207

Demehri, Shadmehr; Turkoz, Ahu; Manivasagam, Sindhu; Yockey, Laura J; Turkoz, Mustafa; Kopan, Raphael 2012. Elevated epidermal thymic stromal lymphopoietin levels establish an antitumor environment in the skin. Cancer cell, 22 4, 494-505

Kopan, Raphael 2012. Notch signaling. Cold Spring Harbor perspectives in biology, 4 10,

Lee, Jacob S; Cella, Marina; McDonald, Keely G; Garlanda, Cecilia; Kennedy, Gregory D; Nukaya, Manabu; Mantovani, Alberto; Kopan, Raphael; Bradfield, Christopher A; Newberry, Rodney D; Colonna, Marco 2012. AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch. Nature immunology, 13 2, 144-51

Mascia, Francesca; Denning, Mitchell; Kopan, Raphael; Yuspa, Stuart H 2012. The black box illuminated: signals and signaling. The Journal of investigative dermatology, 132 3 Pt 2, 811-9

Morimoto, Mitsuru; Nishinakamura, Ryuichi; Saga, Yumiko; Kopan, Raphael 2012. Different assemblies of Notch receptors coordinate the distribution of the major bronchial Clara, ciliated and neuroendocrine cells. Development (Cambridge, England), 139 23, 4365-73

Sato, Chihiro; Turkoz, Mustafa; Dearborn, Joshua T; Wozniak, David F; Kopan, Raphael; Hass, Matthew R 2012. Loss of RBPj in postnatal excitatory neurons does not cause neurodegeneration or memory impairments in aged mice. PloS one, 7 10, e48180

Tu, Xiaolin; Chen, Jianquan; Lim, Joohyun; Karner, Courtney M; Lee, Seung-Yon; Heisig, Julia; Wiese, Cornelia; Surendran, Kameswaran; Kopan, Raphael; Gessler, Manfred; Long, Fanxin 2012. Physiological notch signaling maintains bone homeostasis via RBPjk and Hey upstream of NFATc1. PLoS genetics, 8 3, e1002577

Zheng, Jin; Watanabe, Hirotaka; Wines-Samuelson, Mary; Zhao, Huailong; Gridley, Thomas; Kopan, Raphael; Shen, Jie 2012. Conditional deletion of Notch1 and Notch2 genes in excitatory neurons of postnatal forebrain does not cause neurodegeneration or reduction of Notch mRNAs and proteins. The Journal of biological chemistry, 287 24, 20356-68

Boyle, Scott C; Kim, Mijin; Valerius, M Todd; McMahon, Andrew P; Kopan, Raphael 2011. Notch pathway activation can replace the requirement for Wnt4 and Wnt9b in mesenchymal-to-epithelial transition of nephron stem cells. Development (Cambridge, England), 138 19, 4245-54

Ilagan, Ma Xenia G; Lim, Sora; Fulbright, Mary; Piwnica-Worms, David; Kopan, Raphael 2011. Real-time imaging of notch activation with a luciferase complementation-based reporter. Science signaling, 4 181, rs7

Liu, Zhenyi; Turkoz, Ahu; Jackson, Erin N; Corbo, Joseph C; Engelbach, John A; Garbow, Joel R; Piwnica-Worms, David R; Kopan, Raphael 2011. Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice. The Journal of clinical investigation, 121 2, 800-8

Pellegrinet, Luca; Rodilla, Veronica; Liu, Zhenyi; Chen, Shuang; Koch, Ute; Espinosa, Lluis; Kaestner, Klaus H; Kopan, Raphael; Lewis, Julian; Radtke, Freddy 2011. Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells. Gastroenterology, 140 4, 1230-1240.e1-7

Raphael, Kopan 2011. Deuterium reveals the dynamics of notch activation. Structure (London, England : 1993), 19 4, 443-4

Surendran, Kameswaran; Kopan, Raphael 2011. Chromatin-based mechanisms of renal epithelial differentiation. Journal of the American Society of Nephrology : JASN, 22 7, 1208-12

Vooijs, Marc; Liu, Zhenyi; Kopan, Raphael 2011. Notch: architect, landscaper, and guardian of the intestine. Gastroenterology, 141 2, 448-59

Arnett, Kelly L; Hass, Matthew; McArthur, Debbie G; Ilagan, Ma Xenia G; Aster, Jon C; Kopan, Raphael; Blacklow, Stephen C 2010. Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes. Nature structural & molecular biology, 17 11, 1312-7

Costantini, Frank; Kopan, Raphael 2010. Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development. Developmental cell, 18 5, 698-712

Dumortier, Alexis; Durham, André-Dante; Di Piazza, Matteo; Vauclair, Sophie; Koch, Ute; Ferrand, Gisèle; Ferrero, Isabel; Demehri, Shadmehr; Song, Lynda Li; Farr, Andrew G; Leonard, Warren J; Kopan, Raphael; Miele, Lucio; Hohl, Daniel; Finke, Daniela; Radtke, Freddy 2010. Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin. PloS one, 5 2, e9258

Johnson, Scott E; Ilagan, M Xenia G; Kopan, Raphael; Barrick, Doug 2010. Thermodynamic analysis of the CSL x Notch interaction: distribution of binding energy of the Notch RAM region to the CSL beta-trefoil domain and the mode of competition with the viral transactivator EBNA2. The Journal of biological chemistry, 285 9, 6681-92

Liu, Zhenyi; Schneider, Daniel L; Kornfeld, Kerry; Kopan, Raphael 2010. Simple copy number determination with reference query pyrosequencing (RQPS). Cold Spring Harbor protocols, 2010 9, pdb.prot5491

Morimoto, Mitsuru; Liu, Zhenyi; Cheng, Hui-Teng; Winters, Niki; Bader, David; Kopan, Raphael 2010. Canonical Notch signaling in the developing lung is required for determination of arterial smooth muscle cells and selection of Clara versus ciliated cell fate. Journal of cell science, 123 Pt 2, 213-24

Surendran, Kameswaran; Boyle, Scott; Barak, Hila; Kim, Mijin; Stomberski, Colin; McCright, Brent; Kopan, Raphael 2010. The contribution of Notch1 to nephron segmentation in the developing kidney is revealed in a sensitized Notch2 background and can be augmented by reducing Mint dosage. Developmental biology, 337 2, 386-95

Surendran, Kameswaran; Selassie, Meron; Liapis, Helen; Krigman, Hannah; Kopan, Raphael 2010. Reduced Notch signaling leads to renal cysts and papillary microadenomas. Journal of the American Society of Nephrology : JASN, 21 5, 819-32

Tong, Youren; Yamaguchi, Hiroo; Giaime, Emilie; Boyle, Scott; Kopan, Raphael; Kelleher, Raymond J; Shen, Jie 2010. Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice. Proceedings of the National Academy of Sciences of the United States of America, 107 21, 9879-84

Zhao, Guojun; Liu, Zhenyi; Ilagan, Ma Xenia G; Kopan, Raphael 2010. Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin. The Journal of neuroscience : the official journal of the Society for Neuroscience, 30 5, 1648-56

Bazzi, Hisham; Demehri, Shadmehr; Potter, Christopher S; Barber, Alison G; Awgulewitsch, Alexander; Kopan, Raphael; Christiano, Angela M 2009. Desmoglein 4 is regulated by transcription factors implicated in hair shaft differentiation. Differentiation; research in biological diversity, 78 5, 292-300

Cai, Jing; Lee, Jonghyeob; Kopan, Raphael; Ma, Liang 2009. Genetic interplays between Msx2 and Foxn1 are required for Notch1 expression and hair shaft differentiation. Developmental biology, 326 2, 420-30

Cras-Méneur, Corentin; Li, Lin; Kopan, Raphael; Permutt, M Alan 2009. Presenilins, Notch dose control the fate of pancreatic endocrine progenitors during a narrow developmental window. Genes & development, 23 17, 2088-101

Demehri, Shadmehr; Kopan, Raphael 2009. Notch signaling in bulge stem cells is not required for selection of hair follicle fate. Development (Cambridge, England), 136 6, 891-6

Demehri, Shadmehr; Morimoto, Mitsuru; Holtzman, Michael J; Kopan, Raphael 2009. Skin-derived TSLP triggers progression from epidermal-barrier defects to asthma. PLoS biology, 7 5, e1000067

Demehri, Shadmehr; Turkoz, Ahu; Kopan, Raphael 2009. Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment. Cancer cell, 16 1, 55-66

Hass, Matthew R; Sato, Chihiro; Kopan, Raphael; Zhao, Guojun 2009. Presenilin: RIP and beyond. Seminars in cell & developmental biology, 20 2, 201-10

Kopan, Raphael; Ilagan, Maria Xenia G 2009. The canonical Notch signaling pathway: unfolding the activation mechanism. Cell, 137 2, 216-33

Liu, Zhenyi; Obenauf, Anna C; Speicher, Michael R; Kopan, Raphael 2009. Rapid identification of homologous recombinants and determination of gene copy number with reference/query pyrosequencing (RQPS). Genome research, 19 11, 2081-9

Morimoto, Mitsuru; Kopan, Raphael 2009. rtTA toxicity limits the usefulness of the SP-C-rtTA transgenic mouse. Developmental biology, 325 1, 171-8

Riesenberg, Amy N; Liu, Zhenyi; Kopan, Raphael; Brown, Nadean L 2009. Rbpj cell autonomous regulation of retinal ganglion cell and cone photoreceptor fates in the mouse retina. The Journal of neuroscience : the official journal of the Society for Neuroscience, 29 41, 12865-77

van Tetering, Geert; van Diest, Paul; Verlaan, Ingrid; van der Wall, Elsken; Kopan, Raphael; Vooijs, Marc 2009. Metalloprotease ADAM10 is required for Notch1 site 2 cleavage. The Journal of biological chemistry, 284 45, 31018-27

Bai, Shuting; Kopan, Raphael; Zou, Wei; Hilton, Matthew J; Ong, Chin-tong; Long, Fanxin; Ross, F Patrick; Teitelbaum, Steven L 2008. NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells. The Journal of biological chemistry, 283 10, 6509-18

Demehri, Shadmehr; Liu, Zhenyi; Lee, Jonghyeob; Lin, Meei-Hua; Crosby, Seth D; Roberts, Christopher J; Grigsby, Perry W; Miner, Jeffrey H; Farr, Andrew G; Kopan, Raphael 2008. Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity. PLoS biology, 6 5, e123

Hilton, Matthew J; Tu, Xiaolin; Wu, Ximei; Bai, Shuting; Zhao, Haibo; Kobayashi, Tatsuya; Kronenberg, Henry M; Teitelbaum, Steven L; Ross, F Patrick; Kopan, Raphael; Long, Fanxin 2008. Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. Nature medicine, 14 3, 306-14

Lee, Jonghyeob; Wu, Wei; Kopan, Raphael 2008. Murine vibrissae cultured in serum-free medium reinitiate anagen. The Journal of investigative dermatology, 128 2, 482-5

Ong, Chin-Tong; Sedy, John R; Murphy, Kenneth M; Kopan, Raphael 2008. Notch and presenilin regulate cellular expansion and cytokine secretion but cannot instruct Th1/Th2 fate acquisition. PloS one, 3 7, e2823

Cheng, Hui-Teng; Kim, Mijin; Valerius, M Todd; Surendran, Kameswaran; Schuster-Gossler, Karin; Gossler, Achim; McMahon, Andrew P; Kopan, Raphael 2007. Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron. Development (Cambridge, England), 134 4, 801-11

Ilagan, Maria Xenia G; Kopan, Raphael 2007. SnapShot: notch signaling pathway. Cell, 128 6, 1246

Khandelwal, Abha; Chandu, Dilip; Roe, Catherine M; Kopan, Raphael; Quatrano, Ralph S 2007. Moonlighting activity of presenilin in plants is independent of gamma-secretase and evolutionarily conserved. Proceedings of the National Academy of Sciences of the United States of America, 104 33, 13337-42

Kopan, Raphael; Cheng, Hui-Teng; Surendran, Kameswaran 2007. Molecular insights into segmentation along the proximal-distal axis of the nephron. Journal of the American Society of Nephrology : JASN, 18 7, 2014-20

Lee, Jonghyeob; Basak, Jacob M; Demehri, Shadmehr; Kopan, Raphael 2007. Bi-compartmental communication contributes to the opposite proliferative behavior of Notch1-deficient hair follicle and epidermal keratinocytes. Development (Cambridge, England), 134 15, 2795-806

Lubman, Olga Y; Ilagan, Ma Xenia G; Kopan, Raphael; Barrick, Doug 2007. Quantitative dissection of the Notch:CSL interaction: insights into the Notch-mediated transcriptional switch. Journal of molecular biology, 365 3, 577-89

Vooijs, Marc; Ong, Chin-Tong; Hadland, Brandon; Huppert, Stacey; Liu, Zhenyi; Korving, Jeroen; van den Born, Maaike; Stappenbeck, Thaddeus; Wu, Yumei; Clevers, Hans; Kopan, Raphael 2007. Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE. Development (Cambridge, England), 134 3, 535-44

Barrick, Doug; Kopan, Raphael 2006. The Notch transcription activation complex makes its move. Cell, 124 5, 883-5

Chandu, Dilip; Huppert, Stacey S; Kopan, Raphael 2006. Analysis of transmembrane domain mutants is consistent with sequential cleavage of Notch by gamma-secretase. Journal of neurochemistry, 96 1, 228-35

Keller, Preston C; Tomita, Taisuke; Hayashi, Ikuo; Chandu, Dilip; Weber, Jason D; Cistola, David P; Kopan, Raphael 2006. A faster migrating variant masquerades as NICD when performing in vitro gamma-secretase assays with bacterially expressed Notch substrates. Biochemistry, 45 16, 5351-8

Ogura, Toshihiko; Mio, Kazuhiro; Hayashi, Ikuo; Miyashita, Hiroyuki; Fukuda, Rie; Kopan, Raphael; Kodama, Tatsuhiko; Hamakubo, Takao; Iwatsubo, Takeshi; Iwastubo, Takeshi; Tomita, Taisuke; Sato, Chikara 2006. Three-dimensional structure of the gamma-secretase complex. Biochemical and biophysical research communications, 343 2, 525-34

Ong, Chin-Tong; Cheng, Hui-Teng; Chang, Li-Wei; Ohtsuka, Toshiyuki; Kageyama, Ryoichiro; Stormo, Gary D; Kopan, Raphael 2006. Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability. The Journal of biological chemistry, 281 8, 5106-19

Weinmaster, Gerry; Kopan, Raphael 2006. A garden of Notch-ly delights. Development (Cambridge, England), 133 17, 3277-82

Yang, Xudong; Tomita, Taisuke; Wines-Samuelson, Mary; Beglopoulos, Vassilios; Tansey, Malú G; Kopan, Raphael; Shen, Jie 2006. Notch1 signaling influences v2 interneuron and motor neuron development in the spinal cord. Developmental neuroscience, 28 1-2, 102-17

Cheng, Hui-Teng; Kopan, Raphael 2005. The role of Notch signaling in specification of podocyte and proximal tubules within the developing mouse kidney. Kidney international, 68 5, 1951-2

Huppert, Stacey S; Ilagan, Ma Xenia G; De Strooper, Bart; Kopan, Raphael 2005. Analysis of Notch function in presomitic mesoderm suggests a gamma-secretase-independent role for presenilins in somite differentiation. Developmental cell, 8 5, 677-88

Kiernan, Amy E; Cordes, Ralf; Kopan, Raphael; Gossler, Achim; Gridley, Thomas 2005. The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear. Development (Cambridge, England), 132 19, 4353-62

Lubman, Olga Y; Kopan, Raphael; Waksman, Gabriel; Korolev, Sergey 2005. The crystal structure of a partial mouse Notch-1 ankyrin domain: repeats 4 through 7 preserve an ankyrin fold. Protein science : a publication of the Protein Society, 14 5, 1274-81

Pan, Yonghua; Liu, Zhenyi; Shen, Jie; Kopan, Raphael 2005. Notch1 and 2 cooperate in limb ectoderm to receive an early Jagged2 signal regulating interdigital apoptosis. Developmental biology, 286 2, 472-82

Hadland, Brandon K; Huppert, Stacey S; Kanungo, Jyotshnabala; Xue, Yingzi; Jiang, Rulang; Gridley, Thomas; Conlon, Ronald A; Cheng, Alec M; Kopan, Raphael; Longmore, Gregory D 2004. A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development. Blood, 104 10, 3097-105

Koo, Edward H; Kopan, Raphael 2004. Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration. Nature medicine, 10 Suppl , S26-33

Kopan, Raphael; Ilagan, Ma Xenia G 2004. Gamma-secretase: proteasome of the membrane? Nature reviews. Molecular cell biology, 5 6, 499-504

Lubman, Olga Y; Korolev, Sergey V; Kopan, Raphael 2004. Anchoring notch genetics and biochemistry; structural analysis of the ankyrin domain sheds light on existing data. Molecular cell, 13 5, 619-26

Nichols, Amy M; Pan, Yonghua; Herreman, An; Hadland, Brandon K; De Strooper, Bart; Kopan, Raphael; Huppert, Stacey S 2004. Notch pathway is dispensable for adipocyte specification. Genesis (New York, N.Y. : 2000), 40 1, 40-4

Pan, Yonghua; Lin, Meei-Hua; Tian, Xiaolin; Cheng, Hui-Teng; Gridley, Thomas; Shen, Jie; Kopan, Raphael 2004. gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis. Developmental cell, 7 5, 731-43

Vooijs, Marc; Schroeter, Eric H; Pan, Yonghua; Blandford, Mary; Kopan, Raphael 2004. Ectodomain shedding and intramembrane cleavage of mammalian Notch proteins is not regulated through oligomerization. The Journal of biological chemistry, 279 49, 50864-73

Wolfe, Michael S; Kopan, Raphael 2004. Intramembrane proteolysis: theme and variations. Science (New York, N.Y.), 305 5687, 1119-23

Yang, Xudong; Klein, Rüdiger; Tian, Xiaolin; Cheng, Hui-Teng; Kopan, Raphael; Shen, Jie 2004. Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway. Developmental biology, 269 1, 81-94

Cheng, Hui-Teng; Miner, Jeffrey H; Lin, MeeiHua; Tansey, Malú G; Roth, Kevin; Kopan, Raphael 2003. Gamma-secretase activity is dispensable for mesenchyme-to-epithelium transition but required for podocyte and proximal tubule formation in developing mouse kidney. Development (Cambridge, England), 130 20, 5031-42

Hu, Qi-Dong; Ang, Beng-Ti; Karsak, Meliha; Hu, Wei-Ping; Cui, Xiao-Ying; Duka, Tanya; Takeda, Yasuo; Chia, Wendy; Sankar, Natesan; Ng, Yee-Kong; Ling, Eng-Ang; Maciag, Thomas; Small, Deena; Trifonova, Radianna; Kopan, Raphael; Okano, Hideyuki; Nakafuku, Masato; Chiba, Shigeru; Hirai, Hisamaru; Aster, Jon C; Schachner, Melitta; Pallen, Catherine J; Watanabe, Kazutada; Xiao, Zhi-Cheng 2003. F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation. Cell, 115 2, 163-75

Lin, Meei-Hua; Kopan, Raphael 2003. Long-range, nonautonomous effects of activated Notch1 on tissue homeostasis in the nail. Developmental biology, 263 2, 343-59

Schroeter, Eric H; Ilagan, Ma Xenia G; Brunkan, Anne L; Hecimovic, Silva; Li, Yue-ming; Xu, Min; Lewis, Huw D; Saxena, Meera T; De Strooper, Bart; Coonrod, Archie; Tomita, Taisuke; Iwatsubo, Takeshi; Moore, Chad L; Goate, Alison; Wolfe, Michael S; Shearman, Mark; Kopan, Raphael 2003. A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis. Proceedings of the National Academy of Sciences of the United States of America, 100 22, 13075-80

Selkoe, Dennis; Kopan, Raphael 2003. Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration. Annual review of neuroscience, 26 , 565-97

Kopan, Raphael 2002. Notch: a membrane-bound transcription factor. Journal of cell science, 115 Pt 6, 1095-7

Kopan, Raphael; Goate, Alison 2002. Aph-2/Nicastrin: an essential component of gamma-secretase and regulator of Notch signaling and Presenilin localization. Neuron, 33 3, 321-4

Kopan, Raphael; Lee, Jonghyeob; Lin, Meei-Hua; Syder, Andrew J; Kesterson, John; Crutchfield, Neil; Li, Caroline R; Wu, Wei; Books, Jason; Gordon, Jeffrey I 2002. Genetic mosaic analysis indicates that the bulb region of coat hair follicles contains a resident population of several active multipotent epithelial lineage progenitors. Developmental biology, 242 1, 44-57

Michelson, Alan; Kopan, Raphael 2002. Differentiation and gene regulation: toward a holistic understanding of animal development: intercellular communication and transcriptional regulation are two sides of the same coin. Current opinion in genetics & development, 12 5, 499-502