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Photo of  Katherine Holland-Bouley, MD,PhD

Katherine Holland-Bouley, MD,PhD

Professor of Clinical-Affiliate

Pediatrics | College of Medicine

  • Medical Degree: Washington University
  • Doctoral Degree: Washington University (Pharmacology)
  • Internship: Boston Children's Hospital (Pediatrics)
  • Residency: St Louis Children's Hospital (Pediatric Neurology)
Contact Information
Research Interests

Mechanisms of Epileptogenisis

Peer Reviewed Publications

Arya, Ravindra; Tenney, Jeffrey R; Horn, Paul S; Greiner, Hansel M; Holland, Katherine D; Leach, James L; Gelfand, Michael J; Rozhkov, Leonid; Fujiwara, Hisako; Rose, Douglas F; Franz, David N; Mangano, Francesco T 2015. Long-term outcomes of resective epilepsy surgery after invasive presurgical evaluation in children with tuberous sclerosis complex and bilateral multiple lesions. Journal of neurosurgery. Pediatrics, 15 1, 26-33

Arya, Ravindra; Wilson, J Adam; Vannest, Jennifer; Byars, Anna W; Greiner, Hansel M; Buroker, Jason; Fujiwara, Hisako; Mangano, Francesco T; Holland, Katherine D; Horn, Paul S; Crone, Nathan E; Rose, Douglas F 2015. Electrocorticographic language mapping in children by high-gamma synchronization during spontaneous conversation: comparison with conventional electrical cortical stimulation. Epilepsy research, 110 , 78-87

Greiner, Mary V; Greiner, Hansel M; Caré, Marguerite M; Owens, Deanna; Shapiro, Robert; Holland, Katherine 2015. Adding Insult to Injury: Nonconvulsive Seizures in Abusive Head Trauma. Journal of child neurology, ,

Jain, Sejal V; Horn, Paul S; Simakajornboon, Narong; Beebe, Dean W; Holland, Katherine; Byars, Anna W; Glauser, Tracy A 2015. Melatonin improves sleep in children with epilepsy: a randomized, double-blind, crossover study. Sleep medicine, 16 5, 637-44

Jiang, Yifei; Pun, Raymund Y K; Peariso, Katrina; Holland, Katherine D; Lian, Qingquan; Danzer, Steve C 2015. Olfactory Bulbectomy Leads to the Development of Epilepsy in Mice. PloS one, 10 9, e0138178

Arya, Ravindra; Greiner, Hansel M; Horn, Paul S; Turner, Michele; Holland, Katherine D; Mangano, Francesco T 2014. Corpus callosotomy for childhood-onset drug-resistant epilepsy unresponsive to vagus nerve stimulation. Pediatric neurology, 51 6, 800-5

Arya, Ravindra; Greiner, Hansel M; Lewis, Amanda; Horn, Paul S; Mangano, Francesco T; Gonsalves, Cornelia; Holland, Katherine D 2014. Predictors of response to vagus nerve stimulation in childhood-onset medically refractory epilepsy. Journal of child neurology, 29 12, 1652-9

Arya, Ravindra; Holland, Katherine D 2014. In response to comments on Adverse events related to extraoperative invasive EEG monitoring with subdural grid electrodes: a systematic review and meta-analysis. Epilepsia, 55 1, 195-6

Brahimaj, Bledi; Greiner, Hansel M; Leach, James L; Horn, Paul S; Stevenson, Charles B; Miles, Lili; Byars, Anna; Holland, Katherine; Sutton, Mary; Mangano, Francesco T 2014. The surgical management of pediatric brain tumors causing epilepsy: consideration of the epileptogenic zone. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 30 8, 1383-91

Greiner, Hansel M; Horn, Paul S; Arya, Ravindra; Holland, Katherine; Turner, Michele; Alsaidi, Mohammed H; Leach, James L; Mangano, Francesco T 2014. Acute postoperative seizures and long-term outcome following pediatric epilepsy surgery. Seizure, 23 6, 483-6

Leach, James L; Miles, Lili; Henkel, David M; Greiner, Hansel M; Kukreja, Marcia K; Holland, Katherine D; Rose, Douglas F; Zhang, Bin; Mangano, Francesco T 2014. Magnetic resonance imaging abnormalities in the resection region correlate with histopathological type, gliosis extent, and postoperative outcome in pediatric cortical dysplasia. Journal of neurosurgery. Pediatrics, 14 1, 68-80

Vanoye, Carlos G; Gurnett, Christina A; Holland, Katherine D; George, Alfred L; Kearney, Jennifer A 2014. Novel SCN3A variants associated with focal epilepsy in children. Neurobiology of disease, 62 , 313-22

Xiang, Jing; Tenney, Jeffrey R; Korman, Abraham M; Leiken, Kimberly; Rose, Douglas F; Harris, Elana; Yuan, Weihong; Horn, Paul S; Holland, Katherine; Loring, David W; Glauser, Tracy A 2014. Quantification of Interictal Neuromagnetic Activity in Absence Epilepsy with Accumulated Source Imaging. Brain topography, ,

Arya, Ravindra; Greiner, Hansel M; Lewis, Amanda; Mangano, Francesco T; Gonsalves, Cornelia; Holland, Katherine D; Glauser, Tracy A 2013. Vagus nerve stimulation for medically refractory absence epilepsy. Seizure, 22 4, 267-70

Arya, Ravindra; Mangano, Francesco T; Horn, Paul S; Holland, Katherine D; Rose, Douglas F; Glauser, Tracy A 2013. Adverse events related to extraoperative invasive EEG monitoring with subdural grid electrodes: a systematic review and meta-analysis. Epilepsia, 54 5, 828-39

Greiner, Hansel M; Horn, Paul S; Holland, Katherine; Collins, James; Hershey, Andrew D; Glauser, Tracy A 2013. mRNA blood expression patterns in new-onset idiopathic pediatric epilepsy. Epilepsia, 54 2, 272-9

Ngamprasertwong, Pornswan; Michelfelder, Erik C; Arbabi, Shahriar; Choi, Yun Suk; Statile, Christopher; Ding, Lili; Boat, Anne; Eghtesady, Pirooz; Holland, Katherine; Sadhasivam, Senthilkumar 2013. Anesthetic techniques for fetal surgery: effects of maternal anesthesia on intraoperative fetal outcomes in a sheep model. Anesthesiology, 118 4, 796-808

Castro, Olagide W; Santos, Victor R; Pun, Raymund Y K; McKlveen, Jessica M; Batie, Matthew; Holland, Katherine D; Gardner, Margaret; Garcia-Cairasco, Norberto; Herman, James P; Danzer, Steve C 2012. Impact of corticosterone treatment on spontaneous seizure frequency and epileptiform activity in mice with chronic epilepsy. PloS one, 7 9, e46044

Greiner, Hansel M; Holland, Katherine; Leach, James L; Horn, Paul S; Hershey, Andrew D; Rose, Douglas F 2012. Nonconvulsive Status Epilepticus: The Encephalopathic Pediatric Patient. Pediatrics, ,

Greiner, Hansel M; Tillema, Jan-Mendelt; Hallinan, Barbara E; Holland, Katherine; Lee, Ki-Hyeong; Crone, Kerry R 2012. Corpus callosotomy for treatment of pediatric refractory status epilepticus. Seizure : the journal of the British Epilepsy Association, ,

Holland, Katherine; Shinnar, Shlomo 2012. Status epilepticus in children. Handbook of clinical neurology, 108 , 795-812

Pun, Raymund Y K; Rolle, Isaiah J; Lasarge, Candi L; Hosford, Bethany E; Rosen, Jules M; Uhl, Juli D; Schmeltzer, Sarah N; Faulkner, Christian; Bronson, Stefanie L; Murphy, Brian L; Richards, David A; Holland, Katherine D; Danzer, Steve C 2012. Excessive activation of mTOR in postnatally generated granule cells is sufficient to cause epilepsy. Neuron, 75 6, 1022-34

Fountain-Capal, Jamie K; Holland, Katherine D; Gilbert, Donald L; Hallinan, Barbara E 2011. When should clinicians order genetic testing for Dravet syndrome? Pediatric neurology, 45 5, 319-23

Greiner, Hansel M; Park, Yong D; Holland, Katherine; Horn, Paul S; Byars, Anna W; Mangano, Francesco T; Smith, Joseph R; Lee, Mark R; Lee, Ki-Hyeong 2011. Scalp EEG does not predict hemispherectomy outcome. Seizure : the journal of the British Epilepsy Association, 20 10, 758-63

Holland, Katherine D; Hallinan, Barbara E 2010. What causes epileptic encephalopathy in infancy?: the answer may lie in our genes. Neurology, 75 13, 1132-3

Krueger, Darcy A; Care, Marguerite M; Holland, Katherine; Agricola, Karen; Tudor, Cynthia; Mangeshkar, Prajakta; Wilson, Kimberly A; Byars, Anna; Sahmoud, Tarek; Franz, David Neal 2010. Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis. The New England journal of medicine, 363 19, 1801-11

Standridge, Shannon M; Holland, Katherine D; Horn, Paul S 2010. Cardiac arrhythmias and ictal events within an epilepsy monitoring unit. Pediatric neurology, 42 3, 201-5

Holland, Katherine; Kaye, Andrew H 2009. Spinal tumors in neurofibromatosis-2: management considerations - a review. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 16 2, 169-77

Holland, Katherine D 2008. SCN1A variant in a Scandinavian GEFS+ family: a wolf in sheep's clothing? Acta neurologica Scandinavica, 118 5, 344-5; author reply

Holland, Katherine D; Buchhalter, Jeffrey 2008. Hemiconvulsion-hemiplegia-epilepsy syndrome: another case for epilepsy surgery. Neurology, 70 22 Pt 2, 2097-8

Holland, Katherine D; Kearney, Jennifer A; Glauser, Tracy A; Buck, Gerri; Keddache, Mehdi; Blankston, John R; Glaaser, Ian W; Kass, Robert S; Meisler, Miriam H 2008. Mutation of sodium channel SCN3A in a patient with cryptogenic pediatric partial epilepsy. Neuroscience letters, 433 1, 65-70

Lachhwani, Deepak K; Loddenkemper, Tobias; Holland, Katherine D; Kotagal, Prakash; Mascha, Edward; Bingaman, William; Wyllie, Elaine 2008. Discontinuation of medications after successful epilepsy surgery in children. Pediatric neurology, 38 5, 340-4

Holland, Katherine D; Glauser, Tracy A 2007. Response to carbamazepine in children with newly diagnosed partial onset epilepsy. Neurology, 69 6, 596-9

Levisohn, Paul M; Holland, Katherine D 2007. Topiramate or valproate in patients with juvenile myoclonic epilepsy: a randomized open-label comparison. Epilepsy & behavior : E&B, 10 4, 547-52

Loddenkemper, Tobias; Holland, Katherine D; Stanford, Lisa D; Kotagal, Prakash; Bingaman, William; Wyllie, Elaine 2007. Developmental outcome after epilepsy surgery in infancy. Pediatrics, 119 5, 930-5

Holland, Katherine D; Fleming, Michelle T; Cheek, Susannah; Moran, Jennifer L; Beier, David R; Meisler, Miriam H 2006. De novo exon duplication in a new allele of mouse Glra1 (spasmodic). Genetics, 174 4, 2245-7

Chapman, Kevin; Holland, Katherine; Erenberg, Gerald 2003. Seizure exacerbation associated with oxcarbazepine in idiopathic focal epilepsy of childhood. Neurology, 61 7, 1012-3

Holland, Katherine D; Wyllie, Elaine 2002. Outcome after surgical treatment. Neurosurgery clinics of North America, 13 1, 135-44, ix

Graham, Devon L; Herring, Nicole R; Schaefer, Tori L; Holland, Katherine D; Vorhees, Charles V; Williams, Michael T . Electroencephalographic and convulsive effects of binge doses of (+)-methamphetamine, 5-methoxydiisopropyltryptamine, and (±)-3,4-methylenedioxymethamphetamine in rats. The open neuropsychopharmacology journal, 5 , 1-8