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Photo of Yanbo Fan, MD, Ph.D.

Yanbo Fan, MD, Ph.D.

Assistant Professor

Cancer Biology | College of Medicine

Education/Credentials
  • Bachelor's Degree: Hebei Medical University
  • Doctoral Degree: Peking University
  • Fellowship: University of Michigan
Research Interests

The main focuses of my laboratory are: 1) The roles of TFEB in angiogenesis, aortic aneurysm and tumor vascular biology. 2) Identification of novel molecular targets for the treatment of vascular diseases.

Contact Information

Peer Reviewed Publications

Du, Wa; Ren, Lu; Hamblin, Milton H; Fan, Yanbo 2021. Endothelial Cell Glucose Metabolism and Angiogenesis. Biomedicines, 9 2,

Liang, Wenying; Lu, Haocheng; Sun, Jinjian; Zhao, Guizhen; Wang, Huilun; Guo, Yanhong; Eitzman, Daniel; Chen, Y Eugene; Fan, Yanbo#; Zhang, Jifeng 2021. KLF11 Protects against Venous Thrombosis via Suppressing Tissue Factor Expression. Thrombosis and haemostasis, ,

Liang, Wenying; Lu, Haocheng; Sun, Jinjian; Zhao, Guizhen; Wang, Huilun; Guo, Yanhong; Eitzman, Daniel; Chen, Y Eugene; Fan, Yanbo; Zhang, Jifeng 2021. KLF11 Protects against Venous Thrombosis via Suppressing Tissue Factor Expression. Thrombosis and haemostasis, ,

Liang, Wenying; Lu, Haocheng; Sun, Jinjian; Zhao, Guizhen; Wang, Huilun; Guo, Yanhong; Eitzman, Daniel; Chen, Y Eugene; Fan, Yanbo; Zhang, Jifeng 2021. KLF11 Protects against Venous Thrombosis via Suppressing Tissue Factor Expression. Thrombosis and haemostasis, ,

Liang, Wenying; Lu, Haocheng; Sun, Jinjian; Zhao, Guizhen; Wang, Huilun; Guo, Yanhong; Eitzman, Daniel; Chen, Y Eugene; Fan, Yanbo; Zhang, Jifeng 2021. KLF11 Protects against Venous Thrombosis via Suppressing Tissue Factor Expression. Thrombosis and haemostasis, ,

Liu, Yuhao; Zhao, Ying; Shukha, Yousef; Lu, Haocheng; Wang, Lu; Liu, Zhipeng; Liu, Cai; Zhao, Yang; Wang, Huilun; Zhao, Guizhen; Liang, Wenying; Fan, Yanbo; Chang, Lin; Yurdagul, Arif; Pattillo, Christopher B; Orr, A Wayne; Aviram, Michael; Wen, Bo; Garcia-Barrio, Minerva T; Zhang, Jifeng; Liu, Wanqing; Sun, Duxin; Hayek, Tony; Chen, Y Eugene; Rom, Oren 2021. Dysregulated oxalate metabolism is a driver and therapeutic target in atherosclerosis. Cell reports, 36 4, 109420

Lu, Haocheng; Sun, Jinjian; Hamblin, Milton H; Chen, Y Eugene; Fan, Yanbo 2021. Transcription factor EB regulates cardiovascular homeostasis. EBioMedicine, 63 , 103207

Zhao, Guizhen; Chang, Ziyi; Zhao, Yang; Guo, Yanhong; Lu, Haocheng; Liang, Wenying; Rom, Oren; Wang, Huilun; Sun, Jinjian; Zhu, Tianqing; Fan, Yanbo; Chang, Lin; Yang, Bo; Garcia-Barrio, Minerva T; Chen, Y Eugene; Zhang, Jifeng 2021. KLF11 protects against abdominal aortic aneurysm through inhibition of endothelial cell dysfunction. JCI insight, 6 5,

Chang, Ziyi; Zhao, Guizhen; Zhao, Yang; Lu, Haocheng; Xiong, Wenhao; Liang, Wenying; Sun, Jinjian; Wang, Huilun; Zhu, Tianqing; Rom, Oren; Guo, Yanhong; Fan, Yanbo; Chang, Lin; Yang, Bo; Garcia-Barrio, Minerva T; Lin, Jiandie D; Chen, Y Eugene; Zhang, Jifeng 2020. BAF60a Deficiency in Vascular Smooth Muscle Cells Prevents Abdominal Aortic Aneurysm by Reducing Inflammation and Extracellular Matrix Degradation. Arteriosclerosis, thrombosis, and vascular biology, 40 10, 2494-2507

Lu, Haocheng; Sun, Jinjian; Liang, Wenying; Chang, Ziyi; Rom, Oren; Zhao, Yang; Zhao, Guizhen; Xiong, Wenhao; Wang, Huilun; Zhu, Tianqing; Guo, Yanhong; Chang, Lin; Garcia-Barrio, Minerva T; Zhang, Jifeng; Chen, Y Eugene; Fan, Yanbo 2020. Cyclodextrin Prevents Abdominal Aortic Aneurysm via Activation of Vascular Smooth Muscle Cell TFEB. Circulation, ,

Rom, Oren; Liu, Yuhao; Liu, Zhipeng; Zhao, Ying; Wu, Jianfeng; Ghrayeb, Alia; Villacorta, Luis; Fan, Yanbo; Chang, Lin; Wang, Lu; Liu, Cai; Yang, Dongshan; Song, Jun; Rech, Jason C; Guo, Yanhong; Wang, Huilun; Zhao, Guizhen; Liang, Wenying; Koike, Yui; Lu, Haocheng; Koike, Tomonari; Hayek, Tony; Pennathur, Subramaniam; Xi, Chuanwu; Wen, Bo; Sun, Duxin; Garcia-Barrio, Minerva T; Aviram, Michael; Gottlieb, Eyal; Mor, Inbal; Liu, Wanqing; Zhang, Jifeng; Chen, Y Eugene 2020. Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome. Science translational medicine, 12 572,

Sun, Jinjian; Lu, Haocheng; Liang, Wenying; Zhao, Guizhen; Ren, Lu; Hu, Die; Chang, Ziyi; Liu, Yuhao; Garcia-Barrio, Minerva T; Zhang, Jifeng; Chen, Y Eugene; Fan, Yanbo 2020. Endothelial TFEB (Transcription Factor EB) Improves Glucose Tolerance via Upregulation of IRS (Insulin Receptor Substrate) 1 and IRS2. Arteriosclerosis, thrombosis, and vascular biology, , ATVBAHA120315310

Sun, Yifang; Venugopal, Jessica; Guo, Chiao; Fan, Yanbo; Li, Jianping; Gong, Yanjun; Chen, Y Eugene; Zhang, Haoming; Eitzman, Daniel T 2020. Clopidogrel Resistance in a Murine Model of Diet-Induced Obesity Is Mediated by the Interleukin-1 Receptor and Overcome With DT-678. Arteriosclerosis, thrombosis, and vascular biology, , ATVBAHA120314146

Zhang, Xuejing; Tang, Xuelian; Ma, Feifei; Fan, Yanbo; Sun, Ping; Zhu, Tianqing; Zhang, Jifeng; Hamblin, Milton H; Chen, Y Eugene; Yin, Ke-Jie 2020. Endothelium-targeted overexpression of Krüppel-like factor 11 protects the blood-brain barrier function after ischemic brain injury. Brain pathology (Zurich, Switzerland), ,

Zhao, Yang; Chang, Ziyi; Zhao, Guizhen; Lu, Haocheng; Xiong, Wenhao; Liang, Wenying; Wang, Huilun; Villacorta, Luis; Garcia-Barrio, Minerva T; Zhu, Tianqing; Guo, Yanhong; Fan, Yanbo; Chang, Lin; Schopfer, Francisco J; Freeman, Bruce A; Zhang, Jifeng; Chen, Y Eugene 2020. Suppression of Vascular Macrophage Activation by Nitro-Oleic Acid and its Implication for Abdominal Aortic Aneurysm Therapy. Cardiovascular drugs and therapy, ,

Liang, Wenying*; Fan, Yanbo*,#; Lu, Haocheng; Chang, Ziyi; Hu, Wenting; Sun, Jinjian; Wang, Huilun; Zhu, Tianqing; Wang, Jintao; Adili, Reheman; Garcia-Barrio, Minerva T; Holinstat, Michael; Eitzman, Daniel; Zhang, Jifeng; Chen, Y Eugene 2019. KLF11 (Krüppel-Like Factor 11) Inhibits Arterial Thrombosis via Suppression of Tissue Factor in the Vascular Wall. Arteriosclerosis, thrombosis, and vascular biology, 39 3, 402-412

Lu, Haocheng; Sun, Jinjian; Liang, Wenying; Zhang, Jifeng; Rom, Oren; Garcia-Barrio, Minerva T; Li, Shengdi; Villacorta, Luis; Schopfer, Francisco J; Freeman, Bruce A; Chen, Y Eugene; Fan, Yanbo 2019. Novel gene regulatory networks identified in response to nitro-conjugated linoleic acid in human endothelial cells. Physiological genomics, 51 6, 224-233

Rom, Oren; Xu, Guan; Guo, Yanhong; Zhu, Yunhao; Wang, Huilun; Zhang, Jifeng; Fan, Yanbo; Liang, Wenying; Lu, Haocheng; Liu, Yuhao; Aviram, Michael; Liu, Zhipeng; Kim, Seongho; Liu, Wanqing; Wang, Xueding; Chen, Y Eugene; Villacorta, Luis 2019. Nitro-fatty acids protect against steatosis and fibrosis during development of nonalcoholic fatty liver disease in mice. EBioMedicine, 41 , 62-72

Chang, Lin; Xiong, Wenhao; Zhao, Xiangjie; Fan, Yanbo; Guo, Yanhong; Garcia-Barrio, Minerva; Zhang, Jifeng; Jiang, Zhisheng; Lin, Jiandie D; Chen, Y Eugene 2018. Bmal1 in Perivascular Adipose Tissue Regulates Resting-Phase Blood Pressure Through Transcriptional Regulation of Angiotensinogen. Circulation, 138 1, 67-79

Fan, Yanbo#; Lu, Haocheng; Liang, Wenying; Garcia-Barrio, Minerva T; Guo, Yanhong; Zhang, Ji; Zhu, Tianqing; Hao, Yibai; Zhang, Jifeng; Chen, Y Eugene 2018. Endothelial TFEB (Transcription Factor EB) Positively Regulates Postischemic Angiogenesis. Circulation research, 122 7, 945-957

Hu, Wenting; Lu, Haocheng; Zhang, Jifeng; Fan, Yanbo; Chang, Ziyi; Liang, Wenying; Wang, Huilun; Zhu, Tianqing; Garcia-Barrio, Minerva T; Peng, Daoquan; Chen, Y Eugene; Guo, Yanhong 2018. Krüppel-like factor 14, a coronary artery disease associated transcription factor, inhibits endothelial inflammation via NF-?B signaling pathway. Atherosclerosis, 278 , 39-48

Qiao, Congzhen; Li, Shengdi; Lu, Haocheng; Meng, Fan; Fan, Yanbo; Guo, Yanhong; Chen, Y Eugene; Zhang, Jifeng 2018. Laminar Flow Attenuates Macrophage Migration Inhibitory Factor Expression in Endothelial Cells. Scientific reports, 8 1, 2360

Xiong, Wenhao; Zhao, Xiangjie; Villacorta, Luis; Rom, Oren; Garcia-Barrio, Minerva T; Guo, Yanhong; Fan, Yanbo; Zhu, Tianqing; Zhang, Jifeng; Zeng, Rong; Chen, Y Eugene; Jiang, Zhisheng; Chang, Lin 2018. Brown Adipocyte-Specific PPAR? (Peroxisome Proliferator-Activated Receptor ?) Deletion Impairs Perivascular Adipose Tissue Development and Enhances Atherosclerosis in Mice. Arteriosclerosis, thrombosis, and vascular biology, 38 8, 1738-1747

Fan, Yanbo#; Lu, Haocheng; Liang, Wenying; Hu, Wenting; Zhang, Jifeng; Chen, Y Eugene 2017. Krüppel-like factors and vascular wall homeostasis. Journal of molecular cell biology, 9 5, 352-363

Lu, Haocheng*; Fan, Yanbo*,#; Qiao, Congzhen; Liang, Wenying; Hu, Wenting; Zhu, Tianqing; Zhang, Jifeng; Chen, Y Eugene 2017. TFEB inhibits endothelial cell inflammation and reduces atherosclerosis. Science signaling, 10 464,

Zhang, Jifeng; Niimi, Manabu; Yang, Dongshan; Liang, Jingyan; Xu, Jie; Kimura, Tokuhide; Mathew, Anna V; Guo, Yanhong; Fan, Yanbo; Zhu, Tianqing; Song, Jun; Ackermann, Rose; Koike, Yui; Schwendeman, Anna; Lai, Liangxue; Pennathur, Subramaniam; Garcia-Barrio, Minerva; Fan, Jianglin; Chen, Y Eugene 2017. Deficiency of Cholesteryl Ester Transfer Protein Protects Against Atherosclerosis in Rabbits. Arteriosclerosis, thrombosis, and vascular biology, 37 6, 1068-1075

Fan, Yanbo; Lu, Haocheng; Guo, Yanhong; Zhu, Tianqing; Garcia-Barrio, Minerva T; Jiang, Zhisheng; Willer, Cristen J; Zhang, Jifeng; Chen, Y Eugene 2016. Hepatic Transmembrane 6 Superfamily Member 2 Regulates Cholesterol Metabolism in Mice. Gastroenterology, 150 5, 1208-1218

Fan, Yanbo; Willer, Cristen J; Chen, Y Eugene 2016. Reply. Gastroenterology, 151 5, 1034-1035

Zhang, Ji; Qiao, Congzhen; Chang, Lin; Guo, Yanhong; Fan, Yanbo; Villacorta, Luis; Chen, Y Eugene; Zhang, Jifeng 2016. Cardiomyocyte Overexpression of FABP4 Aggravates Pressure Overload-Induced Heart Hypertrophy. PloS one, 11 6, e0157372

Guo, Yanhong; Fan, Yanbo; Zhang, Jifeng; Lomberk, Gwen A; Zhou, Zhou; Sun, Lijie; Mathison, Angela J; Garcia-Barrio, Minerva T; Zhang, Ji; Zeng, Lixia; Li, Lei; Pennathur, Subramaniam; Willer, Cristen J; Rader, Daniel J; Urrutia, Raul; Chen, Y Eugene 2015. Perhexiline activates KLF14 and reduces atherosclerosis by modulating ApoA-I production. The Journal of clinical investigation, 125 10, 3819-30

Yin, Ke-Jie; Hamblin, Milton; Fan, Yanbo; Zhang, Jifeng; Chen, Y Eugene 2015. Krüpple-like factors in the central nervous system: novel mediators in stroke. Metabolic brain disease, 30 2, 401-10

Holmen, Oddgeir L*; Zhang, He*; Fan, Yanbo*; Hovelson, Daniel H; Schmidt, Ellen M; Zhou, Wei; Guo, Yanhong; Zhang, Ji; Langhammer, Arnulf; Løchen, Maja-Lisa; Ganesh, Santhi K; Vatten, Lars; Skorpen, Frank; Dalen, Håvard; Zhang, Jifeng; Pennathur, Subramaniam; Chen, Jin; Platou, Carl; Mathiesen, Ellisiv B; Wilsgaard, Tom; Njølstad, Inger; Boehnke, Michael; Chen, Y Eugene; Abecasis, Gonçalo R; Hveem, Kristian; Willer, Cristen J 2014. Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk. Nature genetics, 46 4, 345-51

Guo, Yanhong; Fan, Yanbo; Zhang, Jifeng; Chang, Lin; Lin, Jiandie D; Chen, Y Eugene 2013. Peroxisome proliferator-activated receptor ? coactivator 1? (PGC-1?) protein attenuates vascular lesion formation by inhibition of chromatin loading of minichromosome maintenance complex in smooth muscle cells. The Journal of biological chemistry, 288 7, 4625-36

Liu, Ling; Zhou, Zhou; Huang, Shengping; Guo, Yanhong; Fan, Yanbo; Zhang, Ji; Zhang, Jifeng; Fu, Mingui; Chen, Y Eugene 2013. Zc3h12c inhibits vascular inflammation by repressing NF-?B activation and pro-inflammatory gene expression in endothelial cells. The Biochemical journal, 451 1, 55-60

Yang, Dongshan; Zhang, Jifeng; Xu, Jie; Zhu, Tianqing; Fan, Yanbo; Fan, Jianglin; Chen, Y Eugene 2013. Production of apolipoprotein C-III knockout rabbits using zinc finger nucleases. Journal of visualized experiments : JoVE, 81, e50957

Yin, Ke-Jie*; Fan, Yanbo*; Hamblin, Milton; Zhang, Jifeng; Zhu, Tainqing; Li, Siming; Hawse, John R; Subramaniam, Malayannan; Song, Chao-Zhong; Urrutia, Raul; Lin, Jiandie D; Chen, Y Eugene 2013. KLF11 mediates PPAR? cerebrovascular protection in ischaemic stroke. Brain : a journal of neurology, 136 Pt 4, 1274-87

Fan, Yanbo; Guo, Yanhong; Zhang, Jifeng; Subramaniam, Malayannan; Song, Chao-Zhong; Urrutia, Raul; Chen, Y Eugene 2012. Krüppel-like factor-11, a transcription factor involved in diabetes mellitus, suppresses endothelial cell activation via the nuclear factor-?B signaling pathway. Arteriosclerosis, thrombosis, and vascular biology, 32 12, 2981-8

Fan, Yanbo; Chen, Y Eugene 2011. Combined therapeutic strategy to improve vascular endothelial function after implantation of sirolimus-eluting stents. Circulation journal : official journal of the Japanese Circulation Society, 75 5, 1051-2

Fan, Yanbo; Guo, Yanhong; Hamblin, Milton; Chang, Lin; Zhang, Jifeng; Chen, Y Eugene 2011. Inhibition of gluconeogenic genes by calcium-regulated heat-stable protein 1 via repression of peroxisome proliferator-activated receptor ?. The Journal of biological chemistry, 286 47, 40584-94

Hamblin, Milton; Chang, Lin; Fan, Yanbo; Zhang, Jifeng; Chen, Y Eugene 2009. PPARs and the cardiovascular system. Antioxidants & redox signaling, 11 6, 1415-52

Zhang, Peng; Wang, Ying; Fan, Yanbo; Tang, Zhihui; Wang, Nanping 2009. Overexpression of adiponectin receptors potentiates the antiinflammatory action of subeffective dose of globular adiponectin in vascular endothelial cells. Arteriosclerosis, thrombosis, and vascular biology, 29 1, 67-74

Fan, Yanbo; Wang, Ying; Tang, Zhihui; Zhang, Hong; Qin, Xiaomei; Zhu, Yi; Guan, Youfei; Wang, Xian; Staels, Bart; Chien, Shu; Wang, Nanping 2008. Suppression of pro-inflammatory adhesion molecules by PPAR-delta in human vascular endothelial cells. Arteriosclerosis, thrombosis, and vascular biology, 28 2, 315-21

Qin, Xiaomei; Xie, Xuefen; Fan, Yanbo; Tian, Jianwei; Guan, Youfei; Wang, Xian; Zhu, Yi; Wang, Nanping 2008. Peroxisome proliferator-activated receptor-delta induces insulin-induced gene-1 and suppresses hepatic lipogenesis in obese diabetic mice. Hepatology (Baltimore, Md.), 48 2, 432-41

Tang, Zhihui; Wang, Ying; Fan, Yanbo; Zhu, Yi; Chien, Shu; Wang, Nanping 2008. Suppression of c-Cbl tyrosine phosphorylation inhibits neointimal formation in balloon-injured rat arteries. Circulation, 118 7, 764-72

Zhang, Hong; Li, Yuanyuan; Fan, Yanbo; Wu, Jing; Zhao, Beilei; Guan, Youfei; Chien, Shu; Wang, Nanping 2008. Klotho is a target gene of PPAR-gamma. Kidney international, 74 6, 732-9

Zhou, Yunfeng; Zhang, Xiaoyan; Chen, Lihong; Wu, Jing; Dang, Huaixin; Wei, Mingfen; Fan, Yanbo; Zhang, Yahua; Zhu, Yi; Wang, Nanping; Breyer, Matthew D; Guan, Youfei 2008. Expression profiling of hepatic genes associated with lipid metabolism in nephrotic rats. American journal of physiology. Renal physiology, 295 3, F662-71

Qin, Xiaomei; Tian, Jianwei; Zhang, Peng; Fan, Yanbo; Chen, Li; Guan, Youfei; Fu, Yi; Zhu, Yi; Chien, Shu; Wang, Nanping 2007. Laminar shear stress up-regulates the expression of stearoyl-CoA desaturase-1 in vascular endothelial cells. Cardiovascular research, 74 3, 506-14