Brain Tumor Center

The UC Brain Tumor Center integrates the research and translational activities of an interdisciplinary team of clinicians and scientists from across the University of Cincinnati and its partner institutions. It is the only academic medical center in the Greater Cincinnati region that offers treatment for all cancers that occur within the brain, and it seeks to discover new diagnostic and therapeutic strategies for tumors that arise in the brain as well as tumors that have spread (metastasized) to the brain.

Research Interests

Researchers in the Brain Tumor Center specialize in primary brain tumors such as glioma and medulloblastoma, as well as metastatic brain tumors. Current areas of focus include:

• Cancer genome vulnerabilities and targeted therapeutics.
• Tumor cell metabolism.
• Immune-cancer cell interactions.
• Tumor Modeling and Patient-derived xenografts.
• Advanced Magnetic Resonance Imaging (MR Imaging).
• Brain vascularization and drug pharmacokinetics.

Clinical Trials

• UCCI-BN-16-01: A Phase 0/1 Pharmacokinetic and Pharmacodynamics and Safety and Tolerability Study of Letrozole in Combination with Standard Therapy in Recurrent High Grade Gliomas.
• A071801: Phase III Trial of Post-Surgical Single Fraction Stereotactic Radiosurgery (SRS) Compared With Fractionated SRS (FSRS) For Resected Metastatic Brain Disease
• NRG-BN003: Determine the Extent of Clinical Benefit of the Addition of Adjuvant Radiotherapy (RT) to Gross Total Resection (GTR) for Patients With Newly Diagnosed World Health Organization (WHO) Grade II Meningioma.
• UCCI-BN-20-01 ChemoBrain Project- The Use of Active vs Receptive Music Listening to Reduce Symptoms of Chemobrain in Breast Cancer Survivors
• Spring Works/MEK-NF-201- Phase 2b Clinical Study of PD-0325901 (MEK inhibitor) in Patients with NF1-associated PN
• A071702: A Phase II Study of Checkpoint Blockade Immunotherapy in Patients with Somatically Hypermutated Recurrent Glioblastoma
• Soma Sengupta, the COVID study