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Yi Zheng, PhD

Professor-Affiliate

Co-Director, Cincinnati Children's Cancer and Blood Diseases Institute, Director, Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Affiliate Faculty Cancer Biology

Pediatrics | College of Medicine

Contact Information

Peer Reviewed Publications

Zhang, Dongsheng; Tang, Wenjuan; Niu, Haitao; Tse, William; Ruan, Hai-Bin; Dolznig, Helmut; Knösel, Thomas; Karl-Heinz, Friedrich; Themanns, Madeleine; Wang, Jiang; Song, Mingquan; Denson, Lee; Kenner, Lukas; Moriggl, Richard; Zheng, Yi; Han, Xiaonan 2024. Monogenic deficiency in murine intestinal Cdc42 leads to mucosal inflammation that induces crypt dysplasia. Genes & diseases, 11 1, 413-429

Dandamudi, Akhila; Akbar, Huzoor; Cancelas, Jose; Zheng, Yi 2023. Rho GTPase Signaling in Platelet Regulation and Implication for Antiplatelet Therapies. International journal of molecular sciences, 24 3,

Dandamudi, Akhila; Seibel, William; Tourdot, Benjamin; Cancelas, Jose A; Akbar, Huzoor; Zheng, Yi 2023. Structure-Activity Relationship Analysis of Rhosin, a RhoA GTPase Inhibitor, Reveals a New Class of Antiplatelet Agents. International journal of molecular sciences, 24 4,

Fan, Cuiqing; Wunderlich, Mark; Cai, Xiongwei; Yan, Zijun; Zhang, Feng; Davis, Ashley Kuenzi; Xu, Lingli; Guo, Fukun; Lu, Q Richard; Azam, Mohammad; Tian, Weidong; Zheng, Yi 2023. Kinase-independent role of mTOR and on-/off-target effects of an mTOR kinase inhibitor. Leukemia, 37 10, 2073-2081

Katayama, Kei-Ichi; Zheng, Yi; Inoue, Norimitsu 2023. Rac is required for the survival of cortical neurons. Experimental neurology, 361 , 114316

Li, Yuehuan; Martin, Taylor Elijah; Hancock, Jonathan Matthew; Li, Rong; Viswanathan, Suvitha; Lydon, John P; Zheng, Yi; Ye, Xiaoqin 2023. Visualization of preimplantation uterine fluid absorption in mice using Alexa Fluor™ 488 Hydrazide†. Biology of reproduction, 108 2, 204-217

Modur, Vishnu; Muhammad, Belal; Yang, Jun-Qi; Zheng, Yi; Komurov, Kakajan; Guo, Fukun 2023. Mechanism of inert inflammation in an immune checkpoint blockade-resistant tumor subtype bearing transcription elongation defects. Cell reports, 42 4, 112364

Wang, Chen; Tu, Zhaowei; Cai, Xiongwei; Wang, Weinan; Davis, Ashely K; Nattamai, Kalpana; Paranjpe, Aditi; Dexheimer, Philip; Wu, Jianqiang; Huang, Frank Lei; Geiger, Hartmut; Huang, Gang; Zheng, Yi 2023. A critical role of RUNX1 in governing megakaryocyte-primed hematopoietic stem cell differentiation. Blood advances, 7 11, 2590-2605

Zhang, Cuiping; Cui, Xiaojing; Liu, Yi; Wang, Fang; Signer, Robert; Nattamai, Kapana; Zhou, Daohong; Zheng, Yi; Geiger, Hartmut; Wan, Fengyi; Liang, Ying 2023. Latexin deletion protects against radiation-induced hematopoietic damages via selective activation of Bcl-2 prosurvival pathway. Haematologica, 108 12, 3464-3470

Akwii, Racheal Grace; Sajib, Md Sanaullah; Zahra, Fatema Tuz; Tullar, Paul; Zabet-Moghaddam, Masoud; Zheng, Yi; Silvio Gutkind, J; Doci, Colleen L; Mikelis, Constantinos M 2022. Angiopoietin-2-induced lymphatic endothelial cell migration drives lymphangiogenesis via the β1 integrin-RhoA-formin axis. Angiogenesis, 25 3, 373-396

Amoah, Amanda; Keller, Anja; Emini, Ramiz; Hoenicka, Markus; Liebold, Andreas; Vollmer, Angelika; Eiwen, Karina; Soller, Karin; Sakk, Vadim; Zheng, Yi; Florian, Maria Carolina; Geiger, Hartmut 2022. Aging of human hematopoietic stem cells is linked to changes in Cdc42 activity. Haematologica, 107 2, 393-402

Hegde, Shailaja; Gasilina, Anjelika; Wunderlich, Mark; Lin, Yuan; Buchholzer, Marcel; Krumbach, Oliver H F; Akbarzadeh, Mohammad; Ahmadian, Mohammad Reza; Seibel, William; Zheng, Yi; Perentesis, John P; Mizukawa, Benjamin E; Vinnedge, Lisa Privette; Cancelas, José A; Nassar, Nicolas N 2022. Inhibition of the RacGEF VAV3 by the small molecule IODVA1 impedes RAC signaling and overcomes resistance to tyrosine kinase inhibition in acute lymphoblastic leukemia. Leukemia, 36 3, 637-647

Hegde, Shailaja; Zheng, Yi; Cancelas, Jose A 2022. Novel blood derived hemostatic agents for bleeding therapy and prophylaxis. Current opinion in hematology, 29 6, 281-289

Kalim, Khalid W; Yang, Jun-Qi; Wunderlich, Mark; Modur, Vishnu; Nguyen, Phuong; Li, Yuan; Wen, Ting; Davis, Ashley Kuenzi; Verma, Ravinder; Lu, Qing Richard; Jegga, Anil G; Zheng, Yi; Guo, Fukun 2022. Targeting of Cdc42 GTPase in regulatory T cells unleashes antitumor T-cell immunity. Journal for immunotherapy of cancer, 10 11,

Katayama, Kei-Ichi; Zheng, Yi; Inoue, Norimitsu 2022. Rac-deficient cerebellar granule neurons die before they migrate to the internal granule layer. Scientific reports, 12 1, 14848

Kim, Kee-Beom; Kim, Dong-Wook; Kim, Youngchul; Tang, Jun; Kirk, Nicole; Gan, Yongyu; Kim, Bongjun; Fang, Bingliang; Park, Jae-Ll; Zheng, Yi; Park, Kwon-Sik 2022. WNT5A-RHOA Signaling Is a Driver of Tumorigenesis and Represents a Therapeutically Actionable Vulnerability in Small Cell Lung Cancer. Cancer research, 82 22, 4219-4233

Kim, Young-Woong; Zara, Greta; Kang, HyunJun; Branciamore, Sergio; O'Meally, Denis; Feng, Yuxin; Kuan, Chia-Yi; Luo, Yingjun; Nelson, Michael S; Brummer, Alex B; Rockne, Russell; Chen, Zhen Bouman; Zheng, Yi; Cardoso, Angelo A; Carlesso, Nadia 2022. Integration of single-cell transcriptomes and biological function reveals distinct behavioral patterns in bone marrow endothelium. Nature communications, 13 1, 7235

Montserrat-Vazquez, Sara; Ali, Noelle J; Matteini, Francesca; Lozano, Javier; Zhaowei, Tu; Mejia-Ramirez, Eva; Marka, Gina; Vollmer, Angelika; Soller, Karin; Sacma, Mehmet; Sakk, Vadim; Mularoni, Loris; Mallm, Jan Philipp; Plass, Mireya; Zheng, Yi; Geiger, Hartmut; Florian, M Carolina 2022. Transplanting rejuvenated blood stem cells extends lifespan of aged immunocompromised mice. NPJ Regenerative medicine, 7 1, 78

Nalapareddy, Kodandaramireddy; Zheng, Yi; Geiger, Hartmut 2022. Aging of intestinal stem cells. Stem cell reports, 17 4, 734-740

Romano, Laurel; Seu, Katie G; Papoin, Julien; Muench, David E; Konstantinidis, Diamantis; Olsson, André; Schlum, Katrina; Chetal, Kashish; Chasis, Joel Anne; Mohandas, Narla; Barnes, Betsy J; Zheng, Yi; Grimes, H Leighton; Salomonis, Nathan; Blanc, Lionel; Kalfa, Theodosia A 2022. Erythroblastic islands foster granulopoiesis in parallel to terminal erythropoiesis. Blood, 140 14, 1621-1634

Tu, Zhaowei; Fan, Cuiqing; Davis, Ashely K; Hu, Mengwen; Wang, Chen; Dandamudi, Akhila; Seu, Katie G; Kalfa, Theodosia A; Lu, Q Richard; Zheng, Yi 2022. Autism-associated chromatin remodeler CHD8 regulates erythroblast cytokinesis and fine-tunes the balance of Rho GTPase signaling. Cell reports, 40 2, 111072

Tu, Zhaowei; Zheng, Yi 2022. Role of ATP-dependent chromatin remodelers in hematopoietic stem and progenitor cell maintenance. Current opinion in hematology, 29 4, 174-180

Zhang, Zheng; Zhang, Feng; Davis, Ashley Kuenzi; Xin, Mei; Walz, Gerd; Tian, Weidong; Zheng, Yi 2022. CDC42 controlled apical-basal polarity regulates intestinal stem cell to transit amplifying cell fate transition via YAP-EGF-mTOR signaling. Cell reports, 38 2, 110009

Chlon, Timothy M; Stepanchick, Emily; Hershberger, Courtney E; Daniels, Noah J; Hueneman, Kathleen M; Kuenzi Davis, Ashley; Choi, Kwangmin; Zheng, Yi; Gurnari, Carmelo; Haferlach, Torsten; Padgett, Richard A; Maciejewski, Jaroslaw P; Starczynowski, Daniel T 2021. Germline DDX41 mutations cause ineffective hematopoiesis and myelodysplasia. Cell stem cell, 28 11, 1966-1981.e6

Duan, Xin; Perveen, Rehana; Dandamudi, Akhila; Adili, Reheman; Johnson, James; Funk, Kevin; Berryman, Mark; Davis, Ashley Kuenzi; Holinstat, Michael; Zheng, Yi; Akbar, Huzoor 2021. Pharmacologic targeting of Cdc42 GTPase by a small molecule Cdc42 activity-specific inhibitor prevents platelet activation and thrombosis. Scientific reports, 11 1, 13170

Fan, Cuiqing; Zhao, Chuntao; Zhang, Feng; Kesarwani, Meenu; Tu, Zhaowei; Cai, Xiongwei; Davis, Ashley Kuenzi; Xu, Lingli; Hochstetler, Cindy L; Chen, Xiaoyi; Guo, Fukun; Huang, Gang; Azam, Mohammad; Tian, Weidong; Lu, Q Richard; Zheng, Yi 2021. Adaptive responses to mTOR gene targeting in hematopoietic stem cells reveal a proliferative mechanism evasive to mTOR inhibition. Proceedings of the National Academy of Sciences of the United States of America, 118 1,

Fan, Yuping; Teng, Yan; Loison, Fabien; Pang, Aiming; Kasorn, Anongnard; Shao, Xinqi; Zhang, Cunling; Ren, Qian; Yu, Hongbo; Zheng, Yi; Cancelas, Jose A; Manis, John; Chai, Li; Park, Shin-Young; Zhao, Li; Xu, Yuanfu; Feng, Sizhou; Silberstein, Leslie E; Ma, Fengxia; Luo, Hongbo R 2021. Targeting multiple cell death pathways extends the shelf life and preserves the function of human and mouse neutrophils for transfusion. Science translational medicine, 13 604,

Guidi, Novella; Marka, Gina; Sakk, Vadim; Zheng, Yi; Florian, Maria Carolina; Geiger, Hartmut 2021. An aged bone marrow niche restrains rejuvenated hematopoietic stem cells. Stem cells (Dayton, Ohio), 39 8, 1101-1106

Hegde, Shailaja; Wellendorf, Ashley M; Zheng, Yi; Cancelas, Jose A 2021. Antioxidant prevents clearance of hemostatically competent platelets after long-term cold storage. Transfusion, 61 2, 557-567

Kalim, Khalid W; Yang, Jun-Qi; Modur, Vishnu; Nguyen, Phuong; Li, Yuan; Zheng, Yi; Guo, Fukun 2021. Graded RhoA GTPase Expression in Treg Cells Distinguishes Tumor Immunity From Autoimmunity. Frontiers in immunology, 12 , 726393

Kandi, Ravinder; Senger, Katharina; Grigoryan, Ani; Soller, Karin; Sakk, Vadim; Schuster, Tanja; Eiwen, Karina; Menon, Manoj B; Gaestel, Matthias; Zheng, Yi; Florian, Maria Carolina; Geiger, Hartmut 2021. Cdc42-Borg4-Septin7 axis regulates HSC polarity and function. EMBO reports, 22 12, e52931

Lin, Yuan; Lu, Shaoyong; Zhang, Jian; Zheng, Yi 2021. Structure of an inactive conformation of GTP-bound RhoA GTPase. Structure (London, England : 1993), 29 6, 553-563.e5

Lin, Yuan; Watanabe-Chailland, Miki; Zheng, Yi 2021. Protocol for structural and biochemical analyses of RhoA GTPase. STAR protocols, 2 2, 100541

Nakamura, Yuka; Ueno, Masaki; Niehaus, Jesse K; Lang, Richard A; Zheng, Yi; Yoshida, Yutaka 2021. Modulation of Both Intrinsic and Extrinsic Factors Additively Promotes Rewiring of Corticospinal Circuits after Spinal Cord Injury. The Journal of neuroscience : the official journal of the Society for Neuroscience, 41 50, 10247-10260

Nalapareddy, Kodandaramireddy; Hassan, Aishlin; Sampson, Leesa L; Zheng, Yi; Geiger, Hartmut 2021. Suppression of elevated Cdc42 activity promotes the regenerative potential of aged intestinal stem cells. iScience, 24 4, 102362

Sertorio, Mathieu; Nowrouzi, Ali; Akbarpour, Mahdi; Chetal, Kashish; Salomonis, Nathan; Brons, Stephan; Mascia, Anthony; Ionascu, Dan; McCauley, Shelby; Kupneski, Taylor; Köthe, Andreas; Debus, Jürgen; Perentesis, John P; Abdollahi, Amir; Zheng, Yi; Wells, Susanne I 2021. Differential transcriptome response to proton versus X-ray radiation reveals novel candidate targets for combinatorial PT therapy in lymphoma. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 155 , 293-303

Sheng, Yue; Ma, Rui; Yu, Chunjie; Wu, Qiong; Zhang, Steven; Paulsen, Kimberly; Zhang, Jiwang; Ni, Hongyu; Huang, Yong; Zheng, Yi; Qian, Zhijian 2021. Role of c-Myc haploinsufficiency in the maintenance of HSCs in mice. Blood, 137 5, 610-623

Tu, Zhaowei; Wang, Chen; Davis, Ashley K; Hu, Mengwen; Zhao, Chuntao; Xin, Mei; Lu, Q Richard; Zheng, Yi 2021. The chromatin remodeler CHD8 governs hematopoietic stem/progenitor survival by regulating ATM-mediated P53 protein stability. Blood, 138 3, 221-233

Zhang, Bin; Nguyen, Le Xuan Truong; Zhao, Dandan; Frankhouser, David E; Wang, Huafeng; Hoang, Dinh Hoa; Qiao, Junjing; Abundis, Christina; Brehove, Matthew; Su, Yu-Lin; Feng, Yuxin; Stein, Anthony; Ghoda, Lucy; Dorrance, Adrianne; Perrotti, Danilo; Chen, Zhen; Han, Anjia; Pichiorri, Flavia; Jin, Jie; Jovanovic-Talisman, Tijana; Caligiuri, Michael A; Kuo, Calvin J; Yoshimura, Akihiko; Li, Ling; Rockne, Russell C; Kortylewski, Marcin; Zheng, Yi; Carlesso, Nadia; Kuo, Ya-Huei; Marcucci, Guido 2021. Treatment-induced arteriolar revascularization and miR-126 enhancement in bone marrow niche protect leukemic stem cells in AML. Journal of hematology & oncology, 14 1, 122

Zhang, Zheng; Liu, Ming; Zheng, Yi 2021. Role of Rho GTPases in stem cell regulation. Biochemical Society transactions, 49 6, 2941-2955

Althoff, Mark; Nayak, Ramesh; Hegde, Shailaja; Wellendorf, Ashley; Bohan, Breanna; Filippi, Marie-Dominique; Xin, Mei; Lu, Richard; Geiger, Hartmut; Zheng, Yi; Diaz-Meco, Maria T; Moscat, Jorge; Cancelas, Jose A 2020. Yap1-Scribble polarization is required for hematopoietic stem cell division and fate. Blood, ,

Florian, Maria Carolina; Leins, Hanna; Gobs, Michael; Han, Yang; Marka, Gina; Soller, Karin; Vollmer, Angelika; Sakk, Vadim; Nattamai, Kalpana J; Rayes, Ahmad; Zhao, Xueheng; Setchell, Kenneth; Mulaw, Medhanie; Wagner, Wolfgang; Zheng, Yi; Geiger, Hartmut 2020. Inhibition of Cdc42 activity extends lifespan and decreases circulating inflammatory cytokines in aged female C57BL/6 mice. Aging cell, , e13208

Muto, Tomoya; Walker, Callum S; Choi, Kwangmin; Hueneman, Kathleen; Smith, Molly A; Gul, Zartash; Garcia-Manero, Guillermo; Ma, Averil; Zheng, Yi; Starczynowski, Daniel T 2020. Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs. Nature immunology, 21 5, 535-545

Papaioannou, Dimitrios; Petri, Andreas; Dovey, Oliver M; Terreri, Sara; Wang, Eric; Collins, Frances A; Woodward, Lauren A; Walker, Allison E; Nicolet, Deedra; Pepe, Felice; Kumchala, Prasanthi; Bill, Marius; Walker, Christopher J; Karunasiri, Malith; Mrózek, Krzysztof; Gardner, Miranda L; Camilotto, Virginia; Zitzer, Nina; Cooper, Jonathan L; Cai, Xiongwei; Rong-Mullins, Xiaoqing; Kohlschmidt, Jessica; Archer, Kellie J; Freitas, Michael A; Zheng, Yi; Lee, Robert J; Aifantis, Iannis; Vassiliou, George; Singh, Guramrit; Kauppinen, Sakari; Bloomfield, Clara D; Dorrance, Adrienne M; Garzon, Ramiro 2020. Author Correction: The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia. Nature communications, 11 1, 3878

Papaioannou, Dimitrios; Petri, Andreas; Dovey, Oliver M; Terreri, Sara; Wang, Eric; Collins, Frances A; Woodward, Lauren A; Walker, Allison E; Nicolet, Deedra; Pepe, Felice; Kumchala, Prasanthi; Bill, Marius; Walker, Christopher J; Karunasiri, Malith; Mrózek, Krzysztof; Gardner, Miranda L; Camilotto, Virginia; Zitzer, Nina; Cooper, Jonathan L; Cai, Xiongwei; Rong-Mullins, Xiaoqing; Kohlschmidt, Jessica; Archer, Kellie J; Freitas, Michael A; Zheng, Yi; Lee, Robert J; Aifantis, Iannis; Vassiliou, George; Singh, Guramrit; Kauppinen, Sakari; Bloomfield, Clara D; Dorrance, Adrienne M; Garzon, Ramiro 2020. Publisher Correction: The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia. Nature communications, 11 1, 204

Sheng, Yue; Ma, Rui; Yu, Chunjie; Wu, Qiong; Zhang, Steven; Paulsen, Kimberly; Zhang, Jiwang; Ni, Hongyu; Huang, Yong; Zheng, Yi; Qian, Zhijian 2020. Role of c-Myc haploinsufficiency in the maintenance of HSCs. Blood, ,

Sheng, Yue; Ma, Rui; Yu, Chunjie; Wu, Qiong; Zhang, Steven; Paulsen, Kimberly; Zhang, Jiwang; Ni, Hongyu; Huang, Yong; Zheng, Yi; Qian, Zhijian 2020. Role of c-Myc haploinsufficiency in the maintenance of HSCs. Blood, ,

Hochstetler, Cindy L; Feng, Yuxin; Sacma, Mehmet; Davis, Ashley K; Rao, Mahil; Kuan, Chia-Yi; You, Li-Ru; Geiger, Hartmut; Zheng, Yi 2019. KRasG12D expression in the bone marrow vascular niche affects hematopoiesis with inflammatory signals. Experimental hematology, ,

Nayak, R C; Hegde, S; Althoff, M J; Wellendorf, A M; Mohmoud, F; Perentesis, J; Reina-Campos, M; Reynaud, D; Zheng, Y; Diaz-Meco, M T; Moscat, J; Cancelas, J A 2019. The signaling axis atypical protein kinase C ?/?-Satb2 mediates leukemic transformation of B-cell progenitors. Nature communications, 10 1, 46

Nguyen, Phuong; Chakrabarti, Jayati; Li, Yuan; Kalim, Khalid W; Zhang, Mengnan; Zhang, Lin; Zheng, Yi; Guo, Fukun 2019. Rational Targeting of Cdc42 Overcomes Drug Resistance of Multiple Myeloma. Frontiers in oncology, 9 , 958

Papaioannou, Dimitrios; Petri, Andreas; Dovey, Oliver M; Terreri, Sara; Wang, Eric; Collins, Frances A; Woodward, Lauren A; Walker, Allison E; Nicolet, Deedra; Pepe, Felice; Kumchala, Prasanthi; Bill, Marius; Walker, Christopher J; Karunasiri, Malith; Mrózek, Krzysztof; Gardner, Miranda L; Camilotto, Virginia; Zitzer, Nina; Cooper, Jonathan L; Cai, Xiongwei; Rong-Mullins, Xiaoqing; Kohlschmidt, Jessica; Archer, Kellie J; Freitas, Michael A; Zheng, Yi; Lee, Robert J; Aifantis, Iannis; Vassiliou, George; Singh, Guramrit; Kauppinen, Sakari; Bloomfield, Clara D; Dorrance, Adrienne M; Garzon, Ramiro 2019. The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia. Nature communications, 10 1, 5351

Xie, Yangyang; Gao, Li; Xu, Chunhui; Chu, Liming; Gao, Lei; Wu, Ruichi; Liu, Yu; Liu, Ting; Sun, Xiao-Jian; Ren, Ruibao; Tang, Jingyan; Zheng, Yi; Zhou, Yong; Shen, Shuhong 2019. ARHGEF12 regulates erythropoiesis and is involved in erythroid regeneration after chemotherapy in acute lymphoblastic leukemia patients. Haematologica, ,

Yang, Jun-Qi; Kalim, Khalid W; Li, Yuan; Duan, Xin; Nguyen, Phuong; Khurana Hershey, Gurjit K; Kroner, John; Ruff, Brandy; Zhang, Li; Salomonis, Nathan; Rochman, Mark; Wen, Ting; Zheng, Yi; Guo, Fukun 2019. Rational targeting Cdc42 restrains Th2 cell differentiation and prevents allergic airway inflammation. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 49 1, 92-107

Yang, Jun-Qi; Kalim, Khalid W; Li, Yuan; Zheng, Yi; Guo, Fukun 2019. Ablation of RhoA impairs Th17 cell differentiation and alleviates house dust mite-triggered allergic airway inflammation. Journal of leukocyte biology, ,

Zahra, Fatema Tuz; Sajib, Md Sanaullah; Ichiyama, Yusuke; Akwii, Racheal Grace; Tullar, Paul E; Cobos, Christopher; Minchew, Shelby A; Doçi, Colleen L; Zheng, Yi; Kubota, Yoshiaki; Gutkind, J Silvio; Mikelis, Constantinos M 2019. Endothelial RhoA GTPase is essential for in vitro endothelial functions but dispensable for physiological in vivo angiogenesis. Scientific reports, 9 1, 11666

Zhang, Cuiping; Fondufe-Mittendorf, Yvonne N; Wang, Chi; Chen, Jin; Cheng, Qiang; Zhou, Daohong; Zheng, Yi; Geiger, Hartmut; Liang, Ying 2019. Latexin regulation by HMGB2 is required for hematopoietic stem cell maintenance. Haematologica, ,

Zhou, Wei; Yang, Yingying; Mei, Congjin; Dong, Panpan; Mu, Shasha; Wu, Hongchu; Zhou, Yonghua; Zheng, Yi; Guo, Fukun; Yang, Jun-Qi 2019. Inhibition of Rho-Kinase Downregulates Th17 Cells and Ameliorates Hepatic Fibrosis by Schistosoma japonicum Infection. Cells, 8 10,

Akbar, H; Duan, X; Piatt, R; Saleem, S; Davis, A K; Tandon, N N; Bergmeier, W; Zheng, Y 2018. Small molecule targeting the Rac1-NOX2 interaction prevents collagen-related peptide and thrombin-induced reactive oxygen species generation and platelet activation. Journal of thrombosis and haemostasis : JTH, 16 10, 2083-2096

Cai, Xiongwei; Zheng, Yi; Speck, Nancy A 2018. A Western Blotting Protocol for Small Numbers of Hematopoietic Stem Cells. Journal of visualized experiments : JoVE, 138,

Cai, Xiongwei; Zhou, Xuan; Zheng, Yi 2018. In Vivo Rescue Assay of RhoA-Deficient Hematopoietic Stem and Progenitor Cells. Methods in molecular biology (Clifton, N.J.), 1821 , 247-256

Chadwick, Michelle L; Lane, Adam; Thomas, Dana; Smith, Amanda R; White, Angela R; Davidson, Dominique; Feng, Yuxin; Boscolo, Elisa; Zheng, Yi; Adams, Denise M; Gupta, Anita; Veillette, André; Chow, Lionel M L 2018. Combined mTOR and MEK inhibition is an effective therapy in a novel mouse model for angiosarcoma. Oncotarget, 9 37, 24750-24765

Du, Wei; Liu, Wei; Mizukawa, Benjamin; Shang, Xun; Sipple, Jared; Wunderlich, Mark; Geiger, Hartmut; Davies, Stella; Mulloy, James; Pang, Qishen; Zheng, Yi 2018. A non-myeloablative conditioning approach for long-term engraftment of human and mouse hematopoietic stem cells. Leukemia, 32 9, 2041-2046

Fang, Jing; Muto, Tomoya; Kleppe, Maria; Bolanos, Lyndsey C; Hueneman, Kathleen M; Walker, Callum S; Sampson, Leesa; Wellendorf, Ashley M; Chetal, Kashish; Choi, Kwangmin; Salomonis, Nathan; Choi, Yongwon; Zheng, Yi; Cancelas, Jose A; Levine, Ross L; Starczynowski, Daniel T 2018. TRAF6 Mediates Basal Activation of NF-?B Necessary for Hematopoietic Stem Cell Homeostasis. Cell reports, 22 5, 1250-1262

Florian, M Carolina; Klose, Markus; Sacma, Mehmet; Jablanovic, Jelena; Knudson, Luke; Nattamai, Kalpana J; Marka, Gina; Vollmer, Angelika; Soller, Karin; Sakk, Vadim; Cabezas-Wallscheid, Nina; Zheng, Yi; Mulaw, Medhanie A; Glauche, Ingmar; Geiger, Hartmut 2018. Aging alters the epigenetic asymmetry of HSC division. PLoS biology, 16 9, e2003389

Grigoryan, Ani; Guidi, Novella; Senger, Katharina; Liehr, Thomas; Soller, Karin; Marka, Gina; Vollmer, Angelika; Markaki, Yolanda; Leonhardt, Heinrich; Buske, Christian; Lipka, Daniel B; Plass, Christoph; Zheng, Yi; Mulaw, Medhanie A; Geiger, Hartmut; Florian, Maria Carolina 2018. LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells. Genome biology, 19 1, 189

Hayashi, Yoshihiro; Zhang, Yue; Yokota, Asumi; Yan, Xiaomei; Liu, Jinqin; Choi, Kwangmin; Li, Bing; Sashida, Goro; Peng, Yanyan; Xu, Zefeng; Huang, Rui; Zhang, Lulu; Freudiger, George M; Wang, Jingya; Dong, Yunzhu; Zhou, Yile; Wang, Jieyu; Wu, Lingyun; Bu, Jiachen; Chen, Aili; Zhao, Xinghui; Sun, Xiujuan; Chetal, Kashish; Olsson, Andre; Watanabe, Miki; Romick-Rosendale, Lindsey E; Harada, Hironori; Shih, Lee-Yung; Tse, William; Bridges, James P; Caligiuri, Michael A; Huang, Taosheng; Zheng, Yi; Witte, David P; Wang, Qian-Fei; Qu, Cheng-Kui; Salomonis, Nathan; Grimes, H Leighton; Nimer, Stephen D; Xiao, Zhijian; Huang, Gang 2018. Pathobiological Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes. Cancer discovery, 8 11, 1438-1457

Hegde, Shailaja; Akbar, Huzoor; Zheng, Yi; Cancelas, Jose A 2018. Towards increasing shelf life and haemostatic potency of stored platelet concentrates. Current opinion in hematology, 25 6, 500-508

Jiang, Xi; Hu, Chao; Ferchen, Kyle; Nie, Ji; Cui, Xiaolong; Chen, Chih-Hong; Cheng, Liting; Zuo, Zhixiang; Seibel, William; He, Chunjiang; Tang, Yixuan; Skibbe, Jennifer R; Wunderlich, Mark; Reinhold, William C; Dong, Lei; Shen, Chao; Arnovitz, Stephen; Ulrich, Bryan; Lu, Jiuwei; Weng, Hengyou; Su, Rui; Huang, Huilin; Wang, Yungui; Li, Chenying; Qin, Xi; Mulloy, James C; Zheng, Yi; Diao, Jiajie; Jin, Jie; Li, Chong; Liu, Paul P; He, Chuan; Chen, Yuan; Chen, Jianjun 2018. Author Correction: Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia. Nature communications, 9 1, 670

Kalim, Khalid W; Yang, Jun-Qi; Li, Yuan; Meng, Yan; Zheng, Yi; Guo, Fukun 2018. Reciprocal Regulation of Glycolysis-Driven Th17 Pathogenicity and Regulatory T Cell Stability by Cdc42. Journal of immunology (Baltimore, Md. : 1950), 200 7, 2313-2326

Liu, Wei; Du, Wei; Shang, Xun; Wang, Lei; Evelyn, Chris; Florian, Maria Carolina; A Ryan, Marnie; Rayes, Ahmad; Zhao, Xueheng; Setchell, Kenneth; Meller, Jarek; Guo, Fukun; Nassar, Nicolas; Geiger, Hartmut; Pang, Qishen; Zheng, Yi 2018. Rational identification of a Cdc42 inhibitor presents a new regimen for long-term hematopoietic stem cell mobilization. Leukemia, ,

Lv, Jiawen; Zeng, Junchao; Guo, Fukun; Li, Yiran; Xu, Mengying; Cheng, Yuanxiong; Zhang, Lin; Cai, Shaoxi; Chen, Yinghua; Zheng, Yi; Hu, Guodong 2018. Endothelial Cdc42 deficiency impairs endothelial regeneration and vascular repair after inflammatory vascular injury. Respiratory research, 19 1, 27

Maliken, Bryan D; Kanisicak, Onur; Karch, Jason; Khalil, Hadi; Fu, Xing; Boyer, Justin G; Prasad, Vikram; Zheng, Yi; Molkentin, Jeffery D 2018. Gata4-Dependent Differentiation of c-Kit+ Derived Endothelial Cells Underlies Artefactual Cardiomyocyte Regeneration in the Heart. Circulation, ,

Mizukawa, Benjamin; O'Brien, Eric; Mulloy, James C; Zheng, Yi 2018. Cell Polarity and Division Symmetry Analyses in Transformed Blood Cells. Methods in molecular biology (Clifton, N.J.), 1821 , 257-266

Sertorio, Mathieu; Perentesis, John P; Vatner, Ralph E; Mascia, Anthony E; Zheng, Yi; Wells, Susanne I 2018. Cancer Cell Metabolism: Implications for X-ray and Particle Radiation Therapy. International journal of particle therapy, 5 1, 40-48

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