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Photo of  Zhongyun Dong, MD,PhD

Zhongyun Dong, MD,PhD


Internal Medicine | College of Medicine

  • Fellowship: The University of Texas MD Anderson Cancer Center
  • Doctoral Degree: Peking Union Medical College (Immunology)
  • Master's Degree: Peking Union Medical College (Immunology)
  • Medical Degree: Anhui Medical University
Contact Information
Research Interests

Prostate Cancer, IFN-b Gene Therapy, Angiogenesis, PCNA inhibitor, Androgen receptor inhibitor, Androgen receptor

Peer Reviewed Publications

Dong, Zhongyun; Meller, Jaroslaw; Succop, Paul; Wang, Jiang; Wikenheiser-Brokamp, Kathryn; Starnes, Sandra; Lu, Shan 2014. Secretory phospholipase A2-IIa upregulates HER/HER2-elicited signaling in lung cancer cells. International journal of oncology, 45 3, 978-84

Chou, Da-Tren; Hong, Daeho; Saha, Partha; Ferrero, Jordan; Lee, Boeun; Tan, Zongqing; Dong, Zhongyun; Kumta, Prashant N 2013. In vitro and in vivo corrosion, cytocompatibility and mechanical properties of biodegradable Mg-Y-Ca-Zr alloys as implant materials. Acta biomaterialia, 9 10, 8518-33

Hong, Daeho; Saha, Partha; Chou, Da-Tren; Lee, Boeun; Collins, Boyce E; Tan, Zongqing; Dong, Zhongyun; Kumta, Prashant N 2013. In vitro degradation and cytotoxicity response of Mg-4% Zn-0.5% Zr (ZK40) alloy as a potential biodegradable material. Acta biomaterialia, 9 10, 8534-47

Cui, L., Chen, P., Tan, Z., and Dong, Z. 2012. Hemostatic gelatin sponge is a superior matrix to Matrigel for estabishment of LNCaP human prostate cancer in nude mice Prostate, DOI:10 1002/, pros. 22520

Cui, L., Dillehay, K. L., Chen, W., Shen, D., Dong, Z., W. Li 2012. Association of the CYP1B1 Leu432Val polymorphism with the risk of prostate cancer: a meta-analysis Mol Biol Reports, 39 , 7465-71

Cui, Lingling; Chen, Pingping; Tan, Zongqing; Li, Wenjie; Dong, Zhongyun 2012. Hemostatic gelatin sponge is a superior matrix to matrigel for establishment of LNCaP human prostate cancer in nude mice. The Prostate, 72 15, 1669-77

Oleksowicz, L., Jiu, Y., Bracken, R.B, Gaitonde, K., Burke, B., Succop, P., Levin, L., Dong, Z., and Lu,S. 2012. Secretory Phospholipase A2-lla is a Target Gene of the HER/HER2-Elicited Pathway and Potential Plasma Biomarket for Poor Prognosis of Prostate Cancer Prostate, 72 , 1140-49

Oleksowicz, Leslie; Liu, Yin; Bracken, R Bruce; Gaitonde, Krishnanath; Burke, Barbara; Succop, Paul; Levin, Linda; Dong, Zhongyun; Lu, Shan 2012. Secretory phospholipase A2-IIa is a target gene of the HER/HER2-elicited pathway and a potential plasma biomarker for poor prognosis of prostate cancer. The Prostate, 72 10, 1140-9

Tan, Z., Chen, P., Schneider, N., Glover, S., Cui, L., Torgue, J., Rixe, O., Spitz, H. B., an Dong, Z. 2012. Significant systemic therapeutic effects of high-LET immunoradiation by Pb-trastuzumab against prostatic tumors of androgen-independent human prostate cancer in mice Int J. Oncol, 40 , 1881-1888

Tan, Z., Wortman, M., Dillehay, K.L., Seibel, W., Evelyn, C. R., Smith, S. J., Malkas, L., Zheng, Y., Lu, S., and Dong, Z. 2012. Small molecule targeting of PCNA chromatin association inhibits tumor cell growth Mol Pharmacol, 81 , 811-9

Tan, Zongqing; Chen, Pingping; Schneider, Nathan; Glover, Samuel; Cui, Lingling; Torgue, Julien; Rixe, Olivier; Spitz, Henry B; Dong, Zhongyun 2012. Significant systemic therapeutic effects of high-LET immunoradiation by 212Pb-trastuzumab against prostatic tumors of androgen-independent human prostate cancer in mice. International journal of oncology, 40 6, 1881-8

Tan, Zongqing; Wortman, Matthew; Dillehay, Kelsey L; Seibel, William L; Evelyn, Chris R; Smith, Shanna J; Malkas, Linda H; Zheng, Yi; Lu, Shan; Dong, Zhongyun 2012. Small-molecule targeting of proliferating cell nuclear antigen chromatin association inhibits tumor cell growth. Molecular pharmacology, 81 6, 811-9

Xue, D., Yun Y., Tan Z., Dong Z., and M. J. Schultz 2012. In Vivo and In Vitro degradation behavior of magnesium alloys as biomaterials J. Mat. Sci. Tech., ,

Yun, Y., Pixley, S., X. Cui, T., Dong, Z., Collins, B., Shanov, V., Ko, S., Pai1, D., Yarmolenko, S., Schulz, M. J., and J. Sankar 2012. Carbon Nanomaterials: From Therapeutics to Regenerative Medicine Nanomedicine and Biotherapeutic Discovery, 2 , 1000104

Dong, Zhongyun; Liu, Yin; Levin, Linda; Oleksowicz, Leslie; Wang, Jiang; Lu, Shan 2011. Vav3 oncogene is involved in regulation of secretory phospholipase A2-IIa expression in prostate cancer. Oncology reports, 25 6, 1511-6

Kupert, E., Anderson, M. Liu, Y., Succop, P., Levin, L., Wang, J., Wikenheisser-Brokamp, K., Chen, P., Ponney, S., Macdonald, T., Dong, Z., Starnes, S. and Lu, S. 2011. Plasma secretory phospholipase A2-lla as a potential biomarker for lung cancer in patients with solitary pulmonary nodules BMC Cancer, 11 , 513

Kupert, Elena; Anderson, Marshall; Liu, Yin; Succop, Paul; Levin, Linda; Wang, Jiang; Wikenheiser-brokamp, Kathryn; Chen, Pingping; Pinney, Susan M; Macdonald, Trudy; Dong, Zhongyun; Starnes, Sandra; Lu, Shan 2011. Plasma secretory phospholipase A2-IIa as a potential biomarker for lung cancer in patients with solitary pulmonary nodules. BMC cancer, 11 , 513

Cho, Hoon-Sung; Dong, Zhongyun; Pauletti, Giovanni M; Zhang, Jiaming; Xu, Hong; Gu, Hongchen; Wang, Lumin; Ewing, Rodney C; Huth, Christopher; Wang, Feng; Shi, Donglu 2010. Fluorescent, superparamagnetic nanospheres for drug storage, targeting, and imaging: a multifunctional nanocarrier system for cancer diagnosis and treatment. ACS nano, 4 9, 5398-404

Dong, Zhongyun; Liu, Yin; Scott, Kieran F; Levin, Linda; Gaitonde, Krishnanath; Bracken, R Bruce; Burke, Barbara; Zhai, Qihui Jim; Wang, Jiang; Oleksowicz, Leslie; Lu, Shan 2010. Secretory phospholipase A2-IIa is involved in prostate cancer progression and may potentially serve as a biomarker for prostate cancer. Carcinogenesis, 31 11, 1948-55

Liu, Yin; Wu, Xiaoyang; Dong, Zhongyun; Lu, Shan 2010. The molecular mechanism of Vav3 oncogene on upregulation of androgen receptor activity in prostate cancer cells. International journal of oncology, 36 3, 623-33

Lu, Shan; Tan, Zongqin; Wortman, Matt; Lu, Shan; Dong, Zhongyun 2010. Regulation of heat shock protein 70-1 expression by androgen receptor and its signaling in human prostate cancer cells. International journal of oncology, 36 2, 459-67

Lu, Shan; Tan, Zongqin; Wortman, Matthew; Lu, Shan; Dong, Zhongyun 2010. Preferential induction of G1 arrest in androgen-responsive human prostate cancer cells by androgen receptor signaling antagonists DL3 and antiandrogen bicalutamide. Cancer letters, 298 2, 250-7

Meng, Qinghang; Peng, Zhimin; Chen, Liang; Si, Jutong; Dong, Zhongyun; Xia, Ying 2010. Nuclear Factor-?B modulates cellular glutathione and prevents oxidative stress in cancer cells. Cancer letters, 299 1, 45-53

Yun, YeoHeung; Dong, Zhongyun; Tan, Zongqing; Schulz, Mark J 2010. Development of an electrode cell impedance method to measure osteoblast cell activity in magnesium-conditioned media. Analytical and bioanalytical chemistry, 396 8, 3009-15

Yun, Yeo-Heung; Eteshola, Edward; Bhattacharya, Amit; Dong, Zhongyun; Shim, Joon-Sub; Conforti, Laura; Kim, Dogyoon; Schulz, Mark J; Ahn, Chong H; Watts, Nelson 2009. Tiny medicine: nanomaterial-based biosensors. Sensors (Basel, Switzerland), 9 11, 9275-99

Guo, Yan; Shi, Donglu; Lian, Jie; Dong, Zhongyun; Wang, Wei; Cho, Hoonsung; Liu, Guokui; Wang, Lumin; Ewing, Rodney C 2008. Quantum dot conjugated hydroxylapatite nanoparticles for in vivo imaging. Nanotechnology, 19 17, 175102

Lee, Kiwon; Liu, Yin; Mo, Jun Qin; Zhang, Jinsong; Dong, Zhongyun; Lu, Shan 2008. Vav3 oncogene activates estrogen receptor and its overexpression may be involved in human breast cancer. BMC cancer, 8 , 158

Liu, Yin; Mo, Jun Qin; Hu, Qiande; Boivin, Gregory; Levin, Linda; Lu, Shan; Yang, Dianer; Dong, Zhongyun; Lu, Shan 2008. Targeted overexpression of vav3 oncogene in prostatic epithelium induces nonbacterial prostatitis and prostate cancer. Cancer research, 68 15, 6396-406

Lu, Shan; Lee, Juwon; Revelo, Monica; Wang, Xiaohong; Lu, Shan; Dong, Zhongyun 2007. Smad3 is overexpressed in advanced human prostate cancer and necessary for progressive growth of prostate cancer cells in nude mice. Clinical cancer research : an official journal of the American Association for Cancer Research, 13 19, 5692-702

Lu, Shan; Wang, Amy; Lu, Shan; Dong, Zhongyun 2007. A novel synthetic compound that interrupts androgen receptor signaling in human prostate cancer cells. Molecular cancer therapeutics, 6 7, 2057-64

Wang, Daren; Lu, Shan; Dong, Zhongyun 2007. Regulation of TGF-beta1 gene transcription in human prostate cancer cells by nitric oxide. The Prostate, 67 16, 1825-33

Yun, YeoHeung; Bange, Adam; Shanov, Vesselin N; Heineman, William R; Halsall, H Brian; Dong, Zhongyun; Jazieh, Abdul; Tu, Yi; Wong, Danny; Pixley, Sarah; Behbehani, Michael; Schulz, Mark J 2007. A carbon nanotube needle biosensor. Journal of nanoscience and nanotechnology, 7 7, 2293-300

Yun, Yeoheung; Dong, Zhongyun; Shanov, Vesselin N; Schulz, Mark J 2007. Electrochemical impedance measurement of prostate cancer cells using carbon nanotube array electrodes in a microfluidic channel. Nanotechnology, 18 46, 465505

Yun, Yeoheung; Gollapudi, Ram; Shanov, Vesselin; Schulz, Mark J; Dong, Zhongyun; Jazieh, Abdul; Heineman, William R; Halsall, H Brian; Wong, Danny K Y; Bange, Adam; Tu, Yi; Subramaniam, Srinivas 2007. Carbon nanotubes grown on stainless steel to form plate and probe electrodes for chemical/biological sensing. Journal of nanoscience and nanotechnology, 7 3, 891-7

Dong, Zhongyun; Liu, Yin; Lu, Shan; Wang, Amy; Lee, Kiwon; Wang, Lu-Hai; Revelo, Monica; Lu, Shan 2006. Vav3 oncogene is overexpressed and regulates cell growth and androgen receptor activity in human prostate cancer. Molecular endocrinology (Baltimore, Md.), 20 10, 2315-25

Lee, Juwon; Wang, Amy; Hu, Qiande; Lu, Shan; Dong, Zhongyun 2006. Adenovirus-mediated interferon-beta gene transfer inhibits angiogenesis in and progression of orthotopic tumors of human prostate cancer cells in nude mice. International journal of oncology, 29 6, 1405-12

Lu, Shan; Dong, Zhongyun 2006. Characterization of TGF-beta-regulated interleukin-8 expression in human prostate cancer cells. The Prostate, 66 9, 996-1004

Zhang, Fahao; Lee, Juwon; Wang, Daren; Dong, Zhongyun 2006. Differential growth of IFN-beta-engineered tumor cells in nude and IFN receptor-null mice. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 26 2, 108-18

Liu, Guozhen; Zhang, Fahao; Lee, Juwon; Dong, Zhongyun 2005. Selective induction of interleukin-8 expression in metastatic melanoma cells by transforming growth factor-beta 1. Cytokine, 31 3, 241-9

Uehara, Hisanori; Troncoso, Patricia; Johnston, Dennis; Bucana, Corazon D; Dinney, Colin; Dong, Zhongyun; Fidler, Isaiah J; Pettaway, Curtis A 2005. Expression of interleukin-8 gene in radical prostatectomy specimens is associated with advanced pathologic stage. The Prostate, 64 1, 40-9

Zhang, Fahao; Lee, Juwon; Lu, Shan; Pettaway, Curtis A; Dong, Zhongyun 2005. Blockade of transforming growth factor-beta signaling suppresses progression of androgen-independent human prostate cancer in nude mice. Clinical cancer research : an official journal of the American Association for Cancer Research, 11 12, 4512-20

Lu, Weixin; Su, Jindong; Kim, Lee Su; Bucana, Corazon D; Donawho, Cherrie; He, Junqing; Fidler, Isaiah J; Dong, Zhongyun 2003. Active specific immunotherapy against occult brain metastasis. Cancer research, 63 6, 1345-50

Ozawa, Shutaro; Lu, Weixin; Bucana, Corazon D; Kanayama, Hiro-Omi; Shinohara, Hisashi; Fidler, Isaiah J; Dong, Zhongyun 2003. Regression of primary murine colon cancer and occult liver metastasis by intralesional injection of lyophilized preparation of insect cells producing murine interferon-beta. International journal of oncology, 22 5, 977-84

Davies, Michael A; Kim, Sun J; Parikh, Nila U; Dong, Zhongyun; Bucana, Corazon D; Gallick, Gary E 2002. Adenoviral-mediated expression of MMAC/PTEN inhibits proliferation and metastasis of human prostate cancer cells. Clinical cancer research : an official journal of the American Association for Cancer Research, 8 6, 1904-14

Harmey, Judith H; Bucana, Corazon D; Lu, Weixin; Byrne, Anne Marie; McDonnell, Susan; Lynch, Conor; Bouchier-Hayes, David; Dong, Zhongyun 2002. Lipopolysaccharide-induced metastatic growth is associated with increased angiogenesis, vascular permeability and tumor cell invasion. International journal of cancer. Journal international du cancer, 101 5, 415-22

Izawa, Jonathan I; Sweeney, Paul; Perrotte, Paul; Kedar, Daniel; Dong, Zhongyun; Slaton, Joel W; Karashima, Takashi; Inoue, Keji; Benedict, William F; Dinney, Colin P N 2002. Inhibition of tumorigenicity and metastasis of human bladder cancer growing in athymic mice by interferon-beta gene therapy results partially from various antiangiogenic effects including endothelial cell apoptosis. Clinical cancer research : an official journal of the American Association for Cancer Research, 8 4, 1258-70

Lu, Weixin; Dong, Zhongyun; Donawho, Cherrie; Fidler, Isaiah J 2002. Specific immunotherapy against occult cancer metastases. International journal of cancer. Journal international du cancer, 100 4, 480-5

Makar, Tapas Kumar; Wilt, Susan; Dong, Zhongyun; Fishman, Paul; Mouradian, M Maral; Dhib-Jalbut, Suhayl 2002. IFN-beta gene transfer into the central nervous system using bone marrow cells as a delivery system. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 22 7, 783-91

Takeuchi, Osamu; Sato, Shintaro; Horiuchi, Takao; Hoshino, Katsuaki; Takeda, Kiyoshi; Dong, Zhongyun; Modlin, Robert L; Akira, Shizuo 2002. Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. Journal of immunology (Baltimore, Md. : 1950), 169 1, 10-4

Zhang, Fahao; Lu, Weixin; Dong, Zhongyun 2002. Tumor-infiltrating macrophages are involved in suppressing growth and metastasis of human prostate cancer cells by INF-beta gene therapy in nude mice. Clinical cancer research : an official journal of the American Association for Cancer Research, 8 9, 2942-51

Shi D.;Cho H.;Huth C.;Wang F.;Dong Z.;Pauletti G.;Lian J.;Wang W.;Liu G.;Bud'Ko S.;Wang L.;Ewing R. 12-18-2009. Conjugation of quantum dots and Fe<inf>3</inf> O<inf>4</inf> on carbon nanot Applied Physics Letters, 95 22,

Yun Y.H.;Shanov V.;Schulz M.J.;Dong Z.;Jazieh A.;Heineman W.R.;Halsall H.B.;Wong D.K.Y.;Bange A.;Tu Y.;Subramaniam S. 12-14-2006. High sensitivity carbon nanotube tower electrodes Sensors and Actuators, B: Chemical, 120 1, 298-304

Koo Y.;Lee H.;Dong Z.;Kotoka R.;Sankar J.;Huang N.;Yun Y. 12-01-2017. The Effects of Static and Dynamic Loading on Biodegradable Magnesium Pins in Vitro and in Vivo Scientific Reports, 7 1,

Dillehay K.;Lu S.;Dong Z. 12-01-2014. Antitumor effects of a novel small molecule targeting PCNA chromatin association in prostate cancer Molecular Cancer Therapeutics, 13 12, 2817-2826

Jang Y.;Tan Z.;Jurey C.;Collins B.;Badve A.;Dong Z.;Park C.;Kim C.S.;Sankar J.;Yun Y. 12-01-2014. Systematic understanding of corrosion behavior of plasma electrolytic oxidation treated AZ31 magnesi Materials Science and Engineering C, 45 , 45-55

Yun Y.H.;Shanov V.N.;Bange A.;Heineman W.R.;Halsall H.B.;Seth G.;Pixley S.K.;Behbehani M.;Bhattacharya A.;Dong Z.;Yarmolenko S.;Kang I.;Schulz M.J. 12-01-2009. Carbon nanotube smart materials for biology and medicine NanoScience in Biomedicine, , 451-484

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Shi D.;Guo Y.;Dong Z.;Lian J.;Wang W.;Liu G.;Wang L.;Ewing R. 11-19-2007. Quantum-dot-activated luminescent carbon nanotubes via a nano scale surface functionalization for in Advanced Materials, 19 22, 4033-4037

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Schneider N.;Lobaugh M.;Tan Z.;Sandwall P.;Chen P.;Glover S.;Cui L.;Murry M.;Dong Z.;Torgue J.;Spitz H. 04-01-2013. Biodistribution of <sup>212</sup>Pb conjugated trastuzumab in mice Journal of Radioanalytical and Nuclear Chemistry, 296 1, 75-81

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Wu J.;Zhao D.;Ohodnicki J.M.;Lee B.;Roy A.;Yao R.;Chen S.;Dong Z.;Heineman W.R.;Kumta P.N. 03-12-2018. In Vitro and in Vivo Evaluation of Multiphase Ultrahigh Ductility Mg-Li-Zn Alloys for Cardiovascular ACS Biomaterials Science and Engineering, 4 3, 919-932

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