Education/CredentialsPhD: The Rockefeller University (Neurobiology and Genetics)BS: Fordham University (Natural Sciences) Contact Information Medical Sciences Building 3005 Office 513-558-7963 Email kruyeraa@ucmail.uc.edu Research InterestsMost research to date has focused on transcriptional, epigenetic, electrophysiological and morphological adaptations within neurons to understand drug addiction and relapse. Instead, Dr. Kruyer and her lab use single cell approaches to characterize astroglial subpopulations within the basal ganglia, the collection of brain nuclei that orchestrate motivated behaviors, including drug seeking. The principal findings of this work demonstrate a dynamic role for astrocytes in suppression of relapse-like behavio... Peer Reviewed Publications Kruyer A, Kalivas PW, Scofield MD. 2023. Astrocyte regulation of synaptic signaling in psychiatric disorders Neuropsychopharmacology, 48 1, 21-36Fu X, Bian C, Kruyer A, Zhou Z, Luo Z, Haque A, Wagner A, Lang R, Fitting S, Robinson C, McRae-Clark A, Amato D, Jiang W. 2022. Cocaine administration protects gut mucosa barrier and reduces plasma level of TNF-a Current Psychopharmacology, 11 2, 1Hodebourg R, Kalivas PW, Kruyer A. 2022. Extrasynaptic therapeutic targets in substance use and stress disorders Trends in Pharmacological Sciences, 43 1, 56-68Huang Y, Kruyer A, Syed S, Kayasandik CB, Papadakis M, Labate D. 2022. Automated detection of GFAP-labeled astrocytes in micrographs using YOLOv5 Scientific Reports, 12 1, Kruyer A, Angelis A, Garcia-Keller C, Li H, Kalivas PW. 2022. Plasticity in astrocyte subpopulations regulates heroin relapse Science Advances, 3 32, Kruyer A. 2022. Astrocyte heterogeneity in regulation of synaptic activity Cells, 11 19, 3135Chioma VC, Kruyer A, Bobadilla AC, Angelis A, Ellison Z, Hodebourg R, Scofield MD, Kalivas PW. 2021. Heroin seeking and extinction from seeking activate matrix metalloproteinases at synapses on distinct populations of accumbens cells Biological Psychiatry, 89 10, 947-58Garcia-Keller C, Carter JS, Kruyer A, Kearns AM, Hopkins JL, Hodebourg R, Kalivas PW, Reichel CM. 2021. Behavioral and accumbens synaptic plasticity induced by cues associated with restraint stress Neuropsychopharmacology, 46 10, 1848-56Kruyer A*, Parilla-Carerro J*, Powell C, Brandt L, Gutwinski S, Angelis A, Chalhoub R, Amato D. 2021. Accumbens D2-MSN hyperactivity drives antipsychotic-induced behavioral supersensitivity Molecular Psychiatry, , Kruyer A, Dixon D, Angelis A, Amato D, Kalivas PW. 2021. Astrocytes in the ventral pallidum extinguish heroin seeking through GAT-3 upregulation and morphological plasticity at D1-MSN terminals Molecular Psychiatry, , Kruyer A and Kalivas PW. 2020. Astrocytes as cellular mediators of cue reactivity in addiction Current Opinion in Pharmacology, 56 , 1-6Kruyer A*, Chioma V*, Kalivas PW. 2020. The opioid-addicted tetrapartite synapse Biological Psychiatry, 87 1, 34-43Amato D, Kruyer A, Samaha AN, Heinz, A. 2019. Hypofunctional dopamine uptake and antipsychotic treatment-resistant schizophrenia Frontiers in Psychiatry, 10 , Cortes-Canteli M, Kruyer A, Fernandez-Nueda I, Marcos-Diaz A, Richards AT, Jno-Charles OC, Rodriguez I, Callejas S, Norris EH, Sanchez-Gonzalez J, Ruiz-Cabello J, Ibanez B, Strickland S, Fuster V. 2019. Long-term anticoagulation with dabigatran delays Alzheimer’s disease pathogenesis in the TgCRND8 mouse model Journal of the American College of Cardiology, 74 15, 1910-23Kruyer A, Ball LE, Townsend DM, Kalivas PW, Uys JD. 2019. Post-translational S-glutathionylation of cofilin increases actin cycling during cocaine seeking PLoS One, 14 9, Kruyer A, Scofield MD, Wood D, Reissner KJ, Kalivas PW. 2019. Heroin cue-evoked astrocytic structural plasticity at nucleus accumbens synapses inhibits heroin seeking Biological Psychiatry, 86 11, 811-819Chung YC, Kruyer A, Yao Y, Feierman E, Richards A, Strickland S, Norris EH. 2016. Hyperhomocysteinemia exacerbates Alzheimer’s disease pathology by way of the Aβ-fibrinogen interaction Journal of Thrombosis and Haemostasis, 14 7, 1442-52Kruyer A, Soplop N, Strickland S, Norris EH. 2015. Chronic hypertension leads to neurodegeneration in the TgSwDI mouse model of Alzheimer’s disease Hypertension, 66 1, 175-82Chen ZL, Yao Y, Norris EH, Kruyer A, Jno-Charles O, Akhmerov A, Strickland S. 2013. Ablation of astrocytic laminin impairs vascular smooth muscle cell function and leads to hemorrhagic stroke Journal of Cell Biology, 202 2, 381-95Lowry ER, Kruyer A, Norris EH, Cederroth CR, Strickland S. 2013. The GluK4 kainate receptor subunit regulates memory, mood, and excitotoxic neurodegeneration Neuroscience, 235 , 215-25Zhou Y, Kruyer A, Ho A, Kreek MJ. 2012. Cocaine place conditioning increases pro-opiomelanocortin gene expression in rat hypothalamus Neuroscience Letters, 530 1, 59-63Morris JZ, Bergman L, Kruyer A, Gertsberg M, Guigova A, Arias R, Pogorzelska M. 2008. Mutations in the Drosophila mitochondrial tRNA amidotransferase, bene/gatA, cause growth defects in mitotic and endoreplicating tissues Genetics, 178 2, 979-87
Research InterestsMost research to date has focused on transcriptional, epigenetic, electrophysiological and morphological adaptations within neurons to understand drug addiction and relapse. Instead, Dr. Kruyer and her lab use single cell approaches to characterize astroglial subpopulations within the basal ganglia, the collection of brain nuclei that orchestrate motivated behaviors, including drug seeking. The principal findings of this work demonstrate a dynamic role for astrocytes in suppression of relapse-like behavio...
Peer Reviewed Publications Kruyer A, Kalivas PW, Scofield MD. 2023. Astrocyte regulation of synaptic signaling in psychiatric disorders Neuropsychopharmacology, 48 1, 21-36Fu X, Bian C, Kruyer A, Zhou Z, Luo Z, Haque A, Wagner A, Lang R, Fitting S, Robinson C, McRae-Clark A, Amato D, Jiang W. 2022. Cocaine administration protects gut mucosa barrier and reduces plasma level of TNF-a Current Psychopharmacology, 11 2, 1Hodebourg R, Kalivas PW, Kruyer A. 2022. Extrasynaptic therapeutic targets in substance use and stress disorders Trends in Pharmacological Sciences, 43 1, 56-68Huang Y, Kruyer A, Syed S, Kayasandik CB, Papadakis M, Labate D. 2022. Automated detection of GFAP-labeled astrocytes in micrographs using YOLOv5 Scientific Reports, 12 1, Kruyer A, Angelis A, Garcia-Keller C, Li H, Kalivas PW. 2022. Plasticity in astrocyte subpopulations regulates heroin relapse Science Advances, 3 32, Kruyer A. 2022. Astrocyte heterogeneity in regulation of synaptic activity Cells, 11 19, 3135Chioma VC, Kruyer A, Bobadilla AC, Angelis A, Ellison Z, Hodebourg R, Scofield MD, Kalivas PW. 2021. Heroin seeking and extinction from seeking activate matrix metalloproteinases at synapses on distinct populations of accumbens cells Biological Psychiatry, 89 10, 947-58Garcia-Keller C, Carter JS, Kruyer A, Kearns AM, Hopkins JL, Hodebourg R, Kalivas PW, Reichel CM. 2021. Behavioral and accumbens synaptic plasticity induced by cues associated with restraint stress Neuropsychopharmacology, 46 10, 1848-56Kruyer A*, Parilla-Carerro J*, Powell C, Brandt L, Gutwinski S, Angelis A, Chalhoub R, Amato D. 2021. Accumbens D2-MSN hyperactivity drives antipsychotic-induced behavioral supersensitivity Molecular Psychiatry, , Kruyer A, Dixon D, Angelis A, Amato D, Kalivas PW. 2021. Astrocytes in the ventral pallidum extinguish heroin seeking through GAT-3 upregulation and morphological plasticity at D1-MSN terminals Molecular Psychiatry, , Kruyer A and Kalivas PW. 2020. Astrocytes as cellular mediators of cue reactivity in addiction Current Opinion in Pharmacology, 56 , 1-6Kruyer A*, Chioma V*, Kalivas PW. 2020. The opioid-addicted tetrapartite synapse Biological Psychiatry, 87 1, 34-43Amato D, Kruyer A, Samaha AN, Heinz, A. 2019. Hypofunctional dopamine uptake and antipsychotic treatment-resistant schizophrenia Frontiers in Psychiatry, 10 , Cortes-Canteli M, Kruyer A, Fernandez-Nueda I, Marcos-Diaz A, Richards AT, Jno-Charles OC, Rodriguez I, Callejas S, Norris EH, Sanchez-Gonzalez J, Ruiz-Cabello J, Ibanez B, Strickland S, Fuster V. 2019. Long-term anticoagulation with dabigatran delays Alzheimer’s disease pathogenesis in the TgCRND8 mouse model Journal of the American College of Cardiology, 74 15, 1910-23Kruyer A, Ball LE, Townsend DM, Kalivas PW, Uys JD. 2019. Post-translational S-glutathionylation of cofilin increases actin cycling during cocaine seeking PLoS One, 14 9, Kruyer A, Scofield MD, Wood D, Reissner KJ, Kalivas PW. 2019. Heroin cue-evoked astrocytic structural plasticity at nucleus accumbens synapses inhibits heroin seeking Biological Psychiatry, 86 11, 811-819Chung YC, Kruyer A, Yao Y, Feierman E, Richards A, Strickland S, Norris EH. 2016. Hyperhomocysteinemia exacerbates Alzheimer’s disease pathology by way of the Aβ-fibrinogen interaction Journal of Thrombosis and Haemostasis, 14 7, 1442-52Kruyer A, Soplop N, Strickland S, Norris EH. 2015. Chronic hypertension leads to neurodegeneration in the TgSwDI mouse model of Alzheimer’s disease Hypertension, 66 1, 175-82Chen ZL, Yao Y, Norris EH, Kruyer A, Jno-Charles O, Akhmerov A, Strickland S. 2013. Ablation of astrocytic laminin impairs vascular smooth muscle cell function and leads to hemorrhagic stroke Journal of Cell Biology, 202 2, 381-95Lowry ER, Kruyer A, Norris EH, Cederroth CR, Strickland S. 2013. The GluK4 kainate receptor subunit regulates memory, mood, and excitotoxic neurodegeneration Neuroscience, 235 , 215-25Zhou Y, Kruyer A, Ho A, Kreek MJ. 2012. Cocaine place conditioning increases pro-opiomelanocortin gene expression in rat hypothalamus Neuroscience Letters, 530 1, 59-63Morris JZ, Bergman L, Kruyer A, Gertsberg M, Guigova A, Arias R, Pogorzelska M. 2008. Mutations in the Drosophila mitochondrial tRNA amidotransferase, bene/gatA, cause growth defects in mitotic and endoreplicating tissues Genetics, 178 2, 979-87
Kruyer A, Kalivas PW, Scofield MD. 2023. Astrocyte regulation of synaptic signaling in psychiatric disorders Neuropsychopharmacology, 48 1, 21-36Fu X, Bian C, Kruyer A, Zhou Z, Luo Z, Haque A, Wagner A, Lang R, Fitting S, Robinson C, McRae-Clark A, Amato D, Jiang W. 2022. Cocaine administration protects gut mucosa barrier and reduces plasma level of TNF-a Current Psychopharmacology, 11 2, 1Hodebourg R, Kalivas PW, Kruyer A. 2022. Extrasynaptic therapeutic targets in substance use and stress disorders Trends in Pharmacological Sciences, 43 1, 56-68Huang Y, Kruyer A, Syed S, Kayasandik CB, Papadakis M, Labate D. 2022. Automated detection of GFAP-labeled astrocytes in micrographs using YOLOv5 Scientific Reports, 12 1, Kruyer A, Angelis A, Garcia-Keller C, Li H, Kalivas PW. 2022. Plasticity in astrocyte subpopulations regulates heroin relapse Science Advances, 3 32, Kruyer A. 2022. Astrocyte heterogeneity in regulation of synaptic activity Cells, 11 19, 3135Chioma VC, Kruyer A, Bobadilla AC, Angelis A, Ellison Z, Hodebourg R, Scofield MD, Kalivas PW. 2021. Heroin seeking and extinction from seeking activate matrix metalloproteinases at synapses on distinct populations of accumbens cells Biological Psychiatry, 89 10, 947-58Garcia-Keller C, Carter JS, Kruyer A, Kearns AM, Hopkins JL, Hodebourg R, Kalivas PW, Reichel CM. 2021. Behavioral and accumbens synaptic plasticity induced by cues associated with restraint stress Neuropsychopharmacology, 46 10, 1848-56Kruyer A*, Parilla-Carerro J*, Powell C, Brandt L, Gutwinski S, Angelis A, Chalhoub R, Amato D. 2021. Accumbens D2-MSN hyperactivity drives antipsychotic-induced behavioral supersensitivity Molecular Psychiatry, , Kruyer A, Dixon D, Angelis A, Amato D, Kalivas PW. 2021. Astrocytes in the ventral pallidum extinguish heroin seeking through GAT-3 upregulation and morphological plasticity at D1-MSN terminals Molecular Psychiatry, , Kruyer A and Kalivas PW. 2020. Astrocytes as cellular mediators of cue reactivity in addiction Current Opinion in Pharmacology, 56 , 1-6Kruyer A*, Chioma V*, Kalivas PW. 2020. The opioid-addicted tetrapartite synapse Biological Psychiatry, 87 1, 34-43Amato D, Kruyer A, Samaha AN, Heinz, A. 2019. Hypofunctional dopamine uptake and antipsychotic treatment-resistant schizophrenia Frontiers in Psychiatry, 10 , Cortes-Canteli M, Kruyer A, Fernandez-Nueda I, Marcos-Diaz A, Richards AT, Jno-Charles OC, Rodriguez I, Callejas S, Norris EH, Sanchez-Gonzalez J, Ruiz-Cabello J, Ibanez B, Strickland S, Fuster V. 2019. Long-term anticoagulation with dabigatran delays Alzheimer’s disease pathogenesis in the TgCRND8 mouse model Journal of the American College of Cardiology, 74 15, 1910-23Kruyer A, Ball LE, Townsend DM, Kalivas PW, Uys JD. 2019. Post-translational S-glutathionylation of cofilin increases actin cycling during cocaine seeking PLoS One, 14 9, Kruyer A, Scofield MD, Wood D, Reissner KJ, Kalivas PW. 2019. Heroin cue-evoked astrocytic structural plasticity at nucleus accumbens synapses inhibits heroin seeking Biological Psychiatry, 86 11, 811-819Chung YC, Kruyer A, Yao Y, Feierman E, Richards A, Strickland S, Norris EH. 2016. Hyperhomocysteinemia exacerbates Alzheimer’s disease pathology by way of the Aβ-fibrinogen interaction Journal of Thrombosis and Haemostasis, 14 7, 1442-52Kruyer A, Soplop N, Strickland S, Norris EH. 2015. Chronic hypertension leads to neurodegeneration in the TgSwDI mouse model of Alzheimer’s disease Hypertension, 66 1, 175-82Chen ZL, Yao Y, Norris EH, Kruyer A, Jno-Charles O, Akhmerov A, Strickland S. 2013. Ablation of astrocytic laminin impairs vascular smooth muscle cell function and leads to hemorrhagic stroke Journal of Cell Biology, 202 2, 381-95Lowry ER, Kruyer A, Norris EH, Cederroth CR, Strickland S. 2013. The GluK4 kainate receptor subunit regulates memory, mood, and excitotoxic neurodegeneration Neuroscience, 235 , 215-25Zhou Y, Kruyer A, Ho A, Kreek MJ. 2012. Cocaine place conditioning increases pro-opiomelanocortin gene expression in rat hypothalamus Neuroscience Letters, 530 1, 59-63Morris JZ, Bergman L, Kruyer A, Gertsberg M, Guigova A, Arias R, Pogorzelska M. 2008. Mutations in the Drosophila mitochondrial tRNA amidotransferase, bene/gatA, cause growth defects in mitotic and endoreplicating tissues Genetics, 178 2, 979-87