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Photo of  Soona Shin, PhD

Soona Shin, PhD

Associate Professor-Affiliate

Surgery | College of Medicine

  • Postdoctoral Study: University of Pennsylvania (Genetics)
  • Doctoral Degree: Johns Hopkins University (Pharmacology and Molecular Sciences)
  • Master's Degree: Seoul National University (Pharmacy)
Contact Information

Peer Reviewed Publications

Rivas, Maria; Johnston, Michael E; Gulati, Ruhi; Kumbaji, Meenasri; Margues Aguiar, Talita Ferreira; Timchenko, Lubov; Krepischi, Ana; Shin, Soona; Bondoc, Alexander; Tiao, Gregory; Geller, James; Timchenko, Nikolai 2021. HDAC1-Dependent Repression of Markers of Hepatocytes and P21 Is Involved in Development of Pediatric Liver Cancer. Cellular and molecular gastroenterology and hepatology, ,

Lee, Sanghoon; Zhou, Ping; Whyte, Senyo; Shin, Soona 2020. Adeno-Associated Virus Serotype 8-Mediated Genetic Labeling of Cholangiocytes in the Neonatal Murine Liver. Pharmaceutics, 12 4,

Cast, Ashley; Valanejad, Leila; Wright, Mary; Nguyen, Phuong; Gupta, Anita; Zhu, Liqin; Shin, Soona; Timchenko, Nikolai 2018. C/EBP?-dependent preneoplastic tumor foci are the origin of hepatocellular carcinoma and aggressive pediatric liver cancer. Hepatology (Baltimore, Md.), 67 5, 1857-1871

D'Souza, Amber M; Jiang, Yanjun; Cast, Ashley; Valanejad, Leila; Wright, Mary; Lewis, Kyle; Kumbaji, Meenasri; Shah, Sheeniza; Smithrud, David; Karns, Rebekah; Shin, Soona; Timchenko, Nikolai 2018. Gankyrin Promotes Tumor-Suppressor Protein Degradation to Drive Hepatocyte Proliferation. Cellular and molecular gastroenterology and hepatology, 6 3, 239-255

Lee, Sanghoon; Zhou, Ping; Gupta, Anita; Shin, Soona 2018. Reactive Ductules Are Associated With Angiogenesis and Tumor Cell Proliferation in Pediatric Liver Cancer. Hepatology communications, 2 10, 1199-1212

Aoki, Reina; Shoshkes-Carmel, Michal; Gao, Nan; Shin, Soona; May, Catherine L; Golson, Maria L; Zahm, Adam M; Ray, Michael; Wiser, Caroline L; Wright, Christopher V E; Kaestner, Klaus H 2016. Foxl1-expressing mesenchymal cells constitute the intestinal stem cell niche. Cellular and molecular gastroenterology and hepatology, 2 2, 175-188

Shin, Soona; Wangensteen, Kirk J; Teta-Bissett, Monica; Wang, Yue J; Mosleh-Shirazi, Elham; Buza, Elizabeth L; Greenbaum, Linda E; Kaestner, Klaus H 2016. Genetic lineage tracing analysis of the cell of origin of hepatotoxin-induced liver tumors in mice. Hepatology (Baltimore, Md.), 64 4, 1163-1177

Shin, Soona; Upadhyay, Naman; Greenbaum, Linda E; Kaestner, Klaus H 2015. Ablation of Foxl1-Cre-labeled hepatic progenitor cells and their descendants impairs recovery of mice from liver injury. Gastroenterology, 148 1, 192-202.e3

Shin, Soona; Kaestner, Klaus H 2014. The origin, biology, and therapeutic potential of facultative adult hepatic progenitor cells. Current topics in developmental biology, 107 , 269-92

Shin, Soona; Le Lay, John; Everett, Logan J; Gupta, Rana; Rafiq, Kiran; Kaestner, Klaus H 2014. CREB mediates the insulinotropic and anti-apoptotic effects of GLP-1 signaling in adult mouse ?-cells. Molecular metabolism, 3 8, 803-12

Bochkis, Irina Mikhailovna; Shin, Soona; Kaestner, Klaus Hermann 2013. Bile acid-induced inflammatory signaling in mice lacking Foxa2 in the liver leads to activation of mTOR and age-onset obesity. Molecular metabolism, 2 4, 447-56

Shin, Soona; Walton, Gabriel; Aoki, Reina; Brondell, Karrie; Schug, Jonathan; Fox, Alan; Smirnova, Olga; Dorrell, Craig; Erker, Laura; Chu, Andrew S; Wells, Rebecca G; Grompe, Markus; Greenbaum, Linda E; Kaestner, Klaus H 2011. Foxl1-Cre-marked adult hepatic progenitors have clonogenic and bilineage differentiation potential. Genes & development, 25 11, 1185-92

Lee, Won-Hee; Choi, Joon-Seok; Byun, Mi-Ran; Koo, Kyo-Tan; Shin, Soona; Lee, Seung-Ki; Surh, Young-Joon 2010. Functional inactivation of triosephosphate isomerase through phosphorylation during etoposide-induced apoptosis in HeLa cells: potential role of Cdk2. Toxicology, 278 2, 224-8

Wakabayashi, Nobunao; Shin, Soona; Slocum, Stephen L; Agoston, Elin S; Wakabayashi, Junko; Kwak, Mi-Kyoung; Misra, Vikas; Biswal, Shyam; Yamamoto, Masayuki; Kensler, Thomas W 2010. Regulation of notch1 signaling by nrf2: implications for tissue regeneration. Science signaling, 3 130, ra52

Wakabayashi, Nobunao; Slocum, Stephen L; Skoko, John J; Shin, Soona; Kensler, Thomas W 2010. When NRF2 talks, who's listening? Antioxidants & redox signaling, 13 11, 1649-63

Sackett, Sara D; Gao, Yan; Shin, Soona; Esterson, Yonah B; Tsingalia, Akivaga; Hurtt, Reginald S; Brondell, Karrie; Kaestner, Klaus H; Greenbaum, Linda E 2009. Foxl1 promotes liver repair following cholestatic injury in mice. Laboratory investigation; a journal of technical methods and pathology, 89 12, 1387-96

Shin, Soona; Wakabayashi, Junko; Yates, Melinda S; Wakabayashi, Nobunao; Dolan, Patrick M; Aja, Susan; Liby, Karen T; Sporn, Michael B; Yamamoto, Masayuki; Kensler, Thomas W 2009. Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide. European journal of pharmacology, 620 1-3, 138-44

Choi, Joon-Seok; Shin, Soona; Jin, Ying Hua; Yim, Hyungshin; Koo, Kyo-Tan; Chun, Kwang-Hoon; Oh, You-Take; Lee, Won Hee; Lee, Seung-Ki 2007. Cyclin-dependent protein kinase 2 activity is required for mitochondrial translocation of Bax and disruption of mitochondrial transmembrane potential during etoposide-induced apoptosis. Apoptosis : an international journal on programmed cell death, 12 7, 1229-41

Kwak, Mi-Kyoung; Cho, Jeong-Min; Huang, Bo; Shin, Soona; Kensler, Thomas W 2007. Role of increased expression of the proteasome in the protective effects of sulforaphane against hydrogen peroxide-mediated cytotoxicity in murine neuroblastoma cells. Free radical biology & medicine, 43 5, 809-17

Shin, Soona; Wakabayashi, Nobunao; Misra, Vikas; Biswal, Shyam; Lee, Gum Hwa; Agoston, Elin S; Yamamoto, Masayuki; Kensler, Thomas W 2007. NRF2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesis. Molecular and cellular biology, 27 20, 7188-97

Jin, Ying Hua; Choi, JoonSeok; Shin, Soona; Lee, Kwang Youl; Park, Jeong Hill; Lee, Seung Ki 2003. Panaxadiol selectively inhibits cyclin A-associated Cdk2 activity by elevating p21WAF1/CIP1 protein levels in mammalian cells. Carcinogenesis, 24 11, 1767-72