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Alexander J. Bondoc, MD

Associate Professor of Clinical-Affiliate

Surgery | College of Medicine

Education/Credentials
  • Fellowship: Cincinnati Children's Hospital Medical Center (Research)
  • Residency: University of Cincinnati (General Surgery)
  • Medical Degree: University of Michigan
  • Bachelor's Degree: Georgetown University (English Literature)
Board Certifications & Licenses

American Board of Surgery (Pediatric Surgery) (Certification Date: 2017-04-25)
American Board of Surgery (Certification Date: 2013-03-18) - (Recertification Date: 2023-10-13)

Contact Information
Research Interests

Biliary atresia, surgical oncology

Clinical Interests

General Surgery

Peer Reviewed Publications

Glaser, Kathryn; Schepers, Emily J; Zwolshen, Harrison M; Lake, Charissa M; Timchenko, Nikolai A; Karns, Rebekah A; Cairo, Stefano; Geller, James I; Tiao, Gregory M; Bondoc, Alexander J 2024. EZH2 is a key component of hepatoblastoma tumor cell growth. Pediatric blood & cancer, 71 2, e30774

Gulati, Ruhi; Fleifil, Yasmeen; Jennings, Katherine; Bondoc, Alex; Tiao, Greg; Geller, James; Timchenko, Lubov; Timchenko, Nikolai 2024. Inhibition of Histone Deacetylase Activity Increases Cisplatin Efficacy to Eliminate Metastatic Cells in Pediatric Liver Cancers. Cancers, 16 13,

Gulati, Ruhi; Lutz, Maggie; Hanlon, Margaret; Cast, Ashley; Karns, Rebekah; Geller, James; Bondoc, Alex; Tiao, Gregory; Timchenko, Lubov; Timchenko, Nikolai A 2024. Cellular origin and molecular mechanisms of lung metastases in patients with aggressive hepatoblastoma. Hepatology communications, 8 2,

Kastenberg, Zachary J; Short, Scott S; Riehle, Kimberly J; Utria, Alan; Lautz, Timothy B; Ott, Katherine C; Murphy, Andrew J; Mansfield, Sara; Lal, Dave R; Hallis, Brian; Murphy, Joseph T; Roach, Jonathan P; Polites, Stephanie F; Beckhorn, Catherine; Tracy, Elisabeth T; Fialkowski, Elizabeth A; Seemann, Natashia M; Bütter, Andreana M; Rich, Barrie S; Glick, Richard D; Bondoc, Alex J; Ofori-Atta, Blessing S; Presson, Angela P; Chen, Stephanie Y; Zamora, Abigail K; Kim, Eugene S; Vasudevan, Sanjeev; Rinehardt, Hannah N; Malek, Marcus M; Lapidus-Krol, Eveline; Putra, Juan; Superina, Riccardo A; Langham, Max R; Meyers, Rebecka L; Tiao, Greg; Dasgupta, Roshni; Baertschiger, Reto 2024. Management of undifferentiated embryonal sarcoma of the liver: A Pediatric Surgical Oncology Research Collaborative study. Pediatric blood & cancer, 71 6, e30975

Riehle, Kimberly J; Vasudevan, Sanjeev A; Bondoc, Alexander; Cuenca, Alex G; Garnier, Hanna; Kastenberg, Zachary; Roach, Jonathan; Weldon, Christopher B; Karpelowsky, Jonathan; Hishiki, Tomoro; Tiao, Gregory 2024. Surgical management of liver tumors. Pediatric blood & cancer, , e31155

Temple, Haley; Donnelly, Bryan; Mohanty, Sujit K; Mowery, Sarah; Poling, Holly M; Pasula, Rajamouli; Hartman, Stephen; Singh, Akaljot; Mourya, Reena; Bondoc, Alexander; Meller, Jaroslaw; Jegga, Anil G; Oyama, Kei; McNeal, Monica; Spearman, Paul; Tiao, Greg 2024. Specific binding sites on Rhesus rotavirus capsid protein dictates the method of endocytosis inducing the murine model of biliary atresia. American journal of physiology. Gastrointestinal and liver physiology, ,

Farooqui, Zishaan; Cortez, Alexander R; PottsIII, John R; Tiao, Gregory M; von Allmen, Daniel; Quillin, Ralph C; Bondoc, Alexander J; Garrison, Aaron P 2023. 10 Year Analysis of Pediatric Surgery Fellowship Match and Operative Experience: Concerning Trends? Annals of surgery, 277 2, e475-e482

Farooqui, Zishaan; Johnston, Michael; Schepers, Emily; Brewer, Nathalie; Hartman, Stephen; Jenkins, Todd; Bondoc, Alexander; Pai, Ahna; Geller, James; Tiao, Gregory M 2023. Quality of Life Outcomes for Patients Who Underwent Conventional Resection and Liver Transplantation for Locally Advanced Hepatoblastoma. Children (Basel, Switzerland), 10 5,

Hall, Ashton D; Kumar, Julia E; Mazur, Jan P; Bondoc, Alexander J; Giffin, Bruce F; Bryant, Whitney K 2023. Dr. Allen Oldfather Whipple (1881-1963): Namesake of the pancreaticoduodenectomy. Journal of medical biography, , 9677720231197430

Hsu, Benson; Bondoc, Alexander; Cuenca, Alex G; Hittle Gigli, Kristin; Laventhal, Naomi; Nakagawa, Thomas 2023. Pediatric Organ Donation and Transplantation: Across the Care Continuum. Pediatrics, 152 2,

Kastenberg, Zachary J; Baertschiger, Reto M; Cuenca, Alex G; Galvan, Nhu Thao Nguyen; Lemoine, Caroline P; Roach, Jonathan P; Walther, Ashley E; Dunn, Stephen P; Goss, John A; Healey, Patrick J; Karpelowsky, Jonathan; Kim, Eugene S; Langham, Max R; Meyers, Rebecka L; Superina, Riccardo A; Tiao, Greg M; Weldon, Christopher B; Bondoc, Alex J; Riehle, Kimberly J; Vasudevan, Sanjeev A 2023. Critical elements of pediatric liver cancer surgery. Seminars in pediatric surgery, 32 5, 151340

Pandurangi, Sindhu; Kim, Seung; Asai, Akihiro; Bondoc, Alexander; Balistreri, William; Campbell, Kathleen; Miethke, Alexander; Peters, Anna; Rogers, Michael; Taylor, Amy; Attia, Suzanna Labib; Gibbons, Troy; Mullapudi, Bhargava; Sheridan, Rachel; Tiao, Greg; Bezerra, Jorge A 2023. Customized Postoperative Therapy Improves Bile Drainage in Biliary Atresia: A Single Center Preliminary Report. Journal of pediatric surgery, 58 8, 1483-1488

Rogers, Michael E; Ambrosino, Teresa; Hatcher, Laura; Bondoc, Alex; Tiao, Greg; Peters, Anna L 2023. Anti-thymocyte globulin induction with delayed introduction of tacrolimus preserves renal function in pediatric liver transplant recipients. Pediatric transplantation, 27 4, e14509

Schepers, Emily J; Glaser, Kathryn; Zwolshen, Harrison M; Hartman, Stephen J; Bondoc, Alexander J 2023. Structural and Functional Impact of Posttranslational Modification of Glypican-3 on Liver Carcinogenesis. Cancer research, 83 12, 1933-1940

Schepers, Emily J; Lake, Charissa; Glaser, Kathryn; Bondoc, Alexander J 2023. Inhibition of Glypican-3 Cleavage Results in Reduced Cell Proliferation in a Liver Cancer Cell Line. The Journal of surgical research, 282 , 118-128

Somers, Katherine M; Tabbouche, Rachel Bernstein; Bondoc, Alexander; Towbin, Alexander J; Ranganathan, Sarangarajan; Tiao, Greg; Geller, James I 2023. Retreatment with Cisplatin May Provide a Survival Advantage for Children with Relapsed/Refractory Hepatoblastoma: An Institutional Experience. Cancers, 15 15,

Whyte, Senyo S; Karns, Rebekah; Min, Kyung-Won; Cho, Jung-Hyun; Lee, Sanghoon; Lake, Charissa; Bondoc, Alexander; Yoon, Je-Hyun; Shin, Soona 2023. Integrated analysis using ToppMiR uncovers altered miRNA- mRNA regulatory networks in pediatric hepatocellular carcinoma-A pilot study. Cancer reports (Hoboken, N.J.), 6 1, e1685

Bondoc, Alexander; Barker, Mitzi; Mullapudi, Bhargava; Miethke, Alexander; Tiao, Gregory 2022. Pediatric Living Donor Liver Transplantation Outcomes-Is it Time for Outcome Optimization of Technical Aspects of Transplantation Using Learning Networks? Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 28 6, 928-930

Bondoc, Alexander; Peters, Anna; Taylor, Amy; Tiao, Greg 2022. Underestimating and Underdiagnosing Biliary Atresia: We Can Do Better. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 28 5, 756-757

Fan, Li; Pan, Qingfei; Yang, Wentao; Koo, Selene C; Tian, Cheng; Li, Liyuan; Lu, Meifen; Brown, Anthony; Ju, Bensheng; Easton, John; Ranganathan, Sarangarajan; Shin, Soona; Bondoc, Alexander; Yang, Jun J; Yu, Jiyang; Zhu, Liqin 2022. A developmentally prometastatic niche to hepatoblastoma in neonatal liver mediated by the Cxcl1/Cxcr2 axis. Hepatology (Baltimore, Md.), 76 5, 1275-1290

Gulati, Ruhi; Johnston, Michael; Rivas, Maria; Cast, Ashley; Kumbaji, Meenasri; Hanlon, Margaret A; Lee, Sanghoon; Zhou, Ping; Lake, Charissa; Schepers, Emily; Min, Kyung-Won; Yoon, Je-Hyun; Karns, Rebekah; Reid, Lola M; Lopez-Terrada, Dolores; Timchenko, Lubov; Parameswaran, Sreeja; Weirauch, Matthew T; Ranganathan, Sarangarajan; Bondoc, Alexander; Geller, James; Tiao, Gregory; Shin, Soona; Timchenko, Nikolai 2022. β-catenin cancer-enhancing genomic regions axis is involved in the development of fibrolamellar hepatocellular carcinoma. Hepatology communications, 6 10, 2950-2963

Rogers, Michael E; Delman, Aaron; Campbell, Kathleen; Miethke, Alexander; Tiao, Greg; Mullapudi, Bhargava; Bondoc, Alex 2022. Children undergoing early liver re-transplantation for primary non-function have improved survival. Pediatric transplantation, 26 7, e14347

Short, Scott S; Kastenberg, Zachary J; Wei, Guo; Bondoc, Alex; Dasgupta, Roshni; Tiao, Greg M; Watters, Erin; Heaton, Todd E; Lotakis, Dimitra; La Quaglia, Michael P; Murphy, Andrew J; Davidoff, Andrew M; Mansfield, Sara A; Langham, Max R; Lautz, Timothy B; Superina, Riccardo A; Ott, Katherine C; Malek, Marcus M; Morgan, Katrina M; Kim, Eugene S; Zamora, Abigail; Lascano, Danny; Roach, Jonathan; Murphy, Joseph T; Rothstein, David H; Vasudevan, Sanjeev A; Whitlock, Richard; Lal, Dave R; Hallis, Brian; Bütter, Andreana; Baertschiger, Reto M; Lapidus-Krol, Eveline; Putra, Juan; Tracy, Elisabeth R; Aldrink, Jennifer H; Apfeld, Jordan; Le, Hau D; Park, Keon Y; Rich, Barrie S; Glick, Richard D; Fialkowski, Elizabeth A; Utria, Alan F; Meyers, Rebecka L; Riehle, Kimberly J 2022. Histologic type predicts disparate outcomes in pediatric hepatocellular neoplasms: A Pediatric Surgical Oncology Research Collaborative study. Cancer, 128 14, 2786-2795

Bondoc, Alexander; Glaser, Kathryn; Jin, Kang; Lake, Charissa; Cairo, Stefano; Geller, James; Tiao, Gregory; Aronow, Bruce 2021. Identification of distinct tumor cell populations and key genetic mechanisms through single cell sequencing in hepatoblastoma. Communications biology, 4 1, 1049

Goldstein, Seth D; Heaton, Todd E; Bondoc, Alexander; Dasgupta, Roshni; Abdelhafeez, Abdelhafeez; Davidoff, Andrew M; Lautz, Timothy B 2021. Evolving applications of fluorescence guided surgery in pediatric surgical oncology: A practical guide for surgeons. Journal of pediatric surgery, 56 2, 215-223

Johnston, Michael Edward; Rivas, Maria Prates; Nicolle, Delphine; Gorse, Aurore; Gulati, Ruhi; Kumbaji, Meenasri; Weirauch, Matthew T; Bondoc, Alexander; Cairo, Stefano; Geller, James; Tiao, Gregory; Timchenko, Nikolai 2021. Olaparib Inhibits Tumor Growth of Hepatoblastoma in Patient-Derived Xenograft Models. Hepatology (Baltimore, Md.), 74 4, 2201-2215

Lake, Charissa M; Bondoc, Alexander J; Dasgupta, Roshni; Jenkins, Todd M; Towbin, Alexander J; Smith, Ethan A; Alonso, Maria H; Geller, James I; Tiao, Gregory M 2021. Indocyanine green is a sensitive adjunct in the identification and surgical management of local and metastatic hepatoblastoma. Cancer medicine, 10 13, 4322-4343

Mohanty, Sujit K; Donnelly, Bryan; Temple, Haley; Bondoc, Alexander; McNeal, Monica; Tiao, Greg 2021. T-Bet Deficiency Attenuates Bile Duct Injury in Experimental Biliary Atresia. Cells, 10 12,

Rivas, Maria; Johnston, Michael E; Gulati, Ruhi; Kumbaji, Meenasri; Margues Aguiar, Talita Ferreira; Timchenko, Lubov; Krepischi, Ana; Shin, Soona; Bondoc, Alexander; Tiao, Gregory; Geller, James; Timchenko, Nikolai 2021. HDAC1-Dependent Repression of Markers of Hepatocytes and P21 Is Involved in Development of Pediatric Liver Cancer. Cellular and molecular gastroenterology and hepatology, 12 5, 1669-1682

Slagle, Cara L; Goldstein, Stuart L; Gavigan, Hailey W; Rowe, James A; Krallman, Kelli A; Kaplan, Heather C; Liu, Chunyan; Ehrlich, Shelley R; Kotagal, Meera; Bondoc, Alexander J; Poindexter, Brenda B 2021. Association between Elevated Urine Neutrophil Gelatinase-Associated Lipocalin and Postoperative Acute Kidney Injury in Neonates. The Journal of pediatrics, 238 , 193-201.e2

Stone, Hillarey K; VandenHeuvel, Katherine; Bondoc, Alexander; Flores, Francisco X; Hooper, David K; Varnell, Charles D 2021. Primary hyperoxaluria diagnosed after kidney transplant: A review of the literature and case report of aggressive renal replacement therapy and lumasiran to prevent allograft loss. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 21 12, 4061-4067

D'Souza, Amber M; Towbin, Alexander J; Gupta, Anita; Alonso, Maria; Nathan, Jaimie D; Bondoc, Alex; Tiao, Greg; Geller, James I 2020. Clinical heterogeneity of pediatric hepatocellular carcinoma. Pediatric blood & cancer, 67 6, e28307

Kassam, Al-Faraaz; Goddard, Gillian R; Johnston, Michael E; Cortez, Alexander R; Trout, Andrew T; Jenkins, Todd M; Miethke, Alexander G; Campbell, Kathleen M; Bezerra, Jorge A; Balistreri, William F; Nathan, Jaimie D; Alonso, Maria H; Tiao, Gregory M; Bondoc, Alexander J 2020. Natural Course of Pediatric Portal Hypertension. Hepatology communications, 4 9, 1346-1352

Malik, Astha; Thanekar, Unmesha; Amarachintha, Surya; Mourya, Reena; Nalluri, Shreya; Bondoc, Alexander; Shivakumar, Pranavkumar 2020. "Complimenting the Complement": Mechanistic Insights and Opportunities for Therapeutics in Hepatocellular Carcinoma. Frontiers in oncology, 10 , 627701

Lake, Charissa M; Tiao, Gregory M; Bondoc, Alexander J 2019. Surgical management of locally-advanced and metastatic hepatoblastoma. Seminars in pediatric surgery, 28 6, 150856

Lim, Irene Isabel P; Bondoc, Alexander J; Geller, James I; Tiao, Gregory M 2018. Hepatoblastoma-The Evolution of Biology, Surgery, and Transplantation. Children (Basel, Switzerland), 6 1,

Chang, Alex L; Cortez, Alexander R; Bondoc, Alexander; Schauer, Daniel P; Fitch, Angela; Shah, Shimul A; Woodle, Steve E; Diwan, Tayyab 2016. Metabolic syndrome in liver transplantation: A preoperative and postoperative concern. Surgery, 160 4, 1111-7

Reznichenko, Aleksandr A; Bondoc, Alexander; Paterno, Flavio; Shah, Shimul A 2016. Hepatic Artery Pseudoaneurysm After Liver Transplantation. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 20 7, 1405-6

Mohanty, Sujit K; Donnelly, Bryan; Bondoc, Alexander; Jafri, Mubeen; Walther, Ashley; Coots, Abigail; McNeal, Monica; Witte, David; Tiao, Gregory M 2013. Rotavirus replication in the cholangiocyte mediates the temporal dependence of murine biliary atresia. PloS one, 8 7, e69069

Bondoc, Alexander J; Taylor, Janice A; Alonso, Maria H; Nathan, Jaimie D; Wang, Yu; Balistreri, William F; Bezerra, Jorge A; Ryckman, Frederick C; Tiao, Gregory M 2012. The beneficial impact of revision of Kasai portoenterostomy for biliary atresia: an institutional study. Annals of surgery, 255 3, 570-6

Wang, Wei; Donnelly, Bryan; Bondoc, Alexander; Mohanty, Sujit K; McNeal, Monica; Ward, Richard; Sestak, Karol; Zheng, Shan; Tiao, Greg 2011. The rhesus rotavirus gene encoding VP4 is a major determinant in the pathogenesis of biliary atresia in newborn mice. Journal of virology, 85 17, 9069-77

Bondoc, Alexander J; Jafri, Mubeen A; Donnelly, Bryan; Mohanty, Sujit K; McNeal, Monica M; Ward, Richard L; Tiao, Greg M 2009. Prevention of the murine model of biliary atresia after live rotavirus vaccination of dams. Journal of pediatric surgery, 44 8, 1479-90

Jafri, Mubeen; Donnelly, Bryan; Bondoc, Alex; Allen, Steven; Tiao, Greg 2009. Cholangiocyte secretion of chemokines in experimental biliary atresia. Journal of pediatric surgery, 44 3, 500-7

Jafri, Mubeen; Donnelly, Bryan; Allen, Steven; Bondoc, Alex; McNeal, Monica; Rennert, Paul D; Weinreb, Paul H; Ward, Richard; Tiao, Greg 2008. Cholangiocyte expression of alpha2beta1-integrin confers susceptibility to rotavirus-induced experimental biliary atresia. American journal of physiology. Gastrointestinal and liver physiology, 295 1, G16-G26

Lake C.M.;Tiao G.M.;Bondoc A.J. 12-01-2019. Surgical management of locally-advanced and metastatic hepatoblastoma Seminars in Pediatric Surgery, 28 6,

Cortez A.R.;Kassam A.F.;Jenkins T.M.;Nathan C.J.;Nathan J.D.;Alonso M.H.;Ryckman F.C.;Tiao G.M.;Bondoc A.J. 11-01-2019. The role of surgical shunts in the treatment of pediatric portal hypertension Surgery (United States), 166 5, 907-913

D'Souza A.;Shah R.;Gupta A.;Towbin A.;Alonso M.;Nathan J.;Bondoc A.;Tiao G.;Geller J. 11-01-2018. Surgical management of children and adolescents with upfront completely resected hepatocellular carc Pediatric Blood and Cancer, 65 11,

Lobeck I.N.;Bondoc A.;Nolan H.;Frischer J.S.;Campbell K.M.;Ryan T.D.;Goldstein S.L.;Nathan J.D.;Alonso M.H.;Tiao G.M. 11-01-2018. Extracorporeal Membrane Oxygenation in a Patient with Biliary Atresia: Case and Review of Extracorpo ASAIO journal (American Society for Artificial Internal Organs : 1992), 64 6, e191-e195

Knod J.;Bondoc A.;Garrison A.;Bischoff A.;Dickie B.;Frischer J. 11-01-2015. Concurrent esophageal atresia with tracheoesophageal fistula and Hirschsprung disease Journal of Pediatric Surgery Case Reports, 3 11, 499-500

Bondoc A.;Abu-El-Haija M.;Nathan J. 08-01-2017. Pediatric pancreas transplantation, including total pancreatectomy with islet autotransplantation Seminars in Pediatric Surgery, 26 4, 250-256

Kocoshis S.;Goldschmidt M.;Nathan J.;El-Chammas K.;Bondoc A.;Tiao G.;Alonso M.;Ubesie A.;Cole C.;Kaul A. 07-01-2019. Esophageal dysmotility: An intrinsic feature of megacystis, microcolon, hypoperistalsis syndrome (MM Journal of Pediatric Surgery, 54 7, 1303-1307

Reznichenko A.;Bondoc A.;Paterno F.;Shah S. 07-01-2016. Hepatic Artery Pseudoaneurysm After Liver Transplantation Journal of Gastrointestinal Surgery, 20 7, 1405-1406

Mohanty S.K.;Lobeck I.;Donnelly B.;Dupree P.;Walther A.;Mowery S.;Coots A.;Bondoc A.;Sheridan R.M.;Poling H.M.;Temple H.;McNeal M.;Sestak K.;Bansal R.;Tiao G. 01-01-2019. Rotavirus Reassortant–Induced Murine Model of Liver Fibrosis Parallels Human Biliary Atresia Hepatology, ,

Bondoc A.;Tiao G. 01-01-2010. Reply to Letter to the Editor by Petersen et al Journal of Pediatric Surgery, 45 1, 286-287