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Photo of  Thomas Geracioti, MD

Thomas Geracioti, MD

Professor - Emeritus (FC)

COM Psychiatry

Education/Credentials
  • Bachelor's Degree: Northwestern University
  • Medical Degree: University of Cincinnati College of Medicine
  • Residency: University of California, San Francisco
  • Fellowship: National Institute of Mental Health
Board Certifications & Licenses

American Board of Psychiatry and Neurology (Psychiatry) (Certification Date: 04/30/1991)

Clinical Interest

Psychiatry

Research Interests

Dr. Geracioti is a psychoneuroendocrinologist at UC and conducts clinical psychoendrocrinology research at the Cincinnati Department of Veterans Affairs Medical Center.

Contact Information
  • Cincinnati Department of Veterans Affairs Medical Center
  • 3200 Vine Street
  • Cincinnati, Ohio 45220
  • Office 513-748-9825
  • Fax 513-475-6967
  • Email thomas.geracioti@uc.edu

Peer Reviewed Publications

Agorastos, Agorastos; Hauger, Richard L; Barkauskas, Donald A; Moeller-Bertram, Tobias; Clopton, Paul L; Haji, Uzair; Lohr, James B; Geracioti, Thomas D; Patel, Piyush M; Chrousos, George P; Baker, Dewleen G 2014. Circadian rhythmicity, variability and correlation of interleukin-6 levels in plasma and cerebrospinal fluid of healthy men. Psychoneuroendocrinology, 44 , 71-82

Geracioti, Thomas D 2014. Tramadol treatment of combat-related posttraumatic stress disorder. Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists, 26 3, 217-21

Sah, Renu; Ekhator, Nosakhare N; Jefferson-Wilson, Lena; Horn, Paul S; Geracioti, Thomas D 2014. Cerebrospinal fluid neuropeptide Y in combat veterans with and without posttraumatic stress disorder. Psychoneuroendocrinology, 40 , 277-83

Baker, Dewleen G; Bertram, Tobias Moeller; Patel, Piyush M; Barkauskas, Donald A; Clopton, Paul; Patel, Sejal; Geracioti, Thomas D; Haji, Uzair; O'Connor, Daniel T; Nievergelt, Caroline M; Hauger, Richard L 2013. Characterization of cerebrospinal fluid (CSF) and plasma NPY levels in normal volunteers over a 24-h timeframe. Psychoneuroendocrinology, 38 10, 2378-82

Barzman, Drew H; Mossman, Douglas; Appel, Kacey; Blom, Thomas J; Strawn, Jeffrey R; Ekhator, Nosa N; Patel, Bianca; DelBello, Melissa P; Sorter, Michael; Klein, David; Geracioti, Thomas D 2013. The association between salivary hormone levels and children's inpatient aggression: a pilot study. The Psychiatric quarterly, 84 4, 475-84

Dodge, Heather S; Ekhator, Nosakhare N; Jefferson-Wilson, Lena; Fischer, Mark; Jansen, Ian; Horn, Paul S; Hurford, William E; Geracioti, Thomas D 2013. Cigarette smokers have reduced risk for post-dural puncture headache. Pain physician, 16 1, E25-30

Geracioti, Thomas D; Jefferson-Wilson, Lena; Strawn, Jeffrey R; Baker, Dewleen G; Dashevsky, Boris A; Horn, Paul S; Ekhator, Nosakhare N 2013. Effect of traumatic imagery on cerebrospinal fluid dopamine and serotonin metabolites in posttraumatic stress disorder. Journal of psychiatric research, 47 7, 995-8

Sah, R; Geracioti, T D 2013. Neuropeptide Y and posttraumatic stress disorder. Molecular psychiatry, 18 6, 646-55

Carpenter, Linda L; Shattuck, Thaddeus T; Tyrka, Audrey R; Geracioti, Thomas D; Price, Lawrence H 2011. Effect of childhood physical abuse on cortisol stress response. Psychopharmacology, 214 1, 367-75

Strawn, Jeffrey R; Adler, Caleb M; Fleck, David E; Hanseman, Dennis; Maue, Danielle K; Bitter, Samantha; Kraft, Elizabeth M; Geracioti, Thomas D; Strakowski, Stephen M; DelBello, Melissa P 2010. Post-traumatic stress symptoms and trauma exposure in youth with first episode bipolar disorder. Early intervention in psychiatry, 4 2, 169-73

Strawn, Jeffrey R; Keeshin, Brooks R; DelBello, Melissa P; Geracioti, Thomas D; Putnam, Frank W 2010. Psychopharmacologic treatment of posttraumatic stress disorder in children and adolescents: a review. The Journal of clinical psychiatry, 71 7, 932-41

Strawn, Jeffrey R; Pyne-Geithman, Gail J; Ekhator, Nosakhare N; Horn, Paul S; Uhde, Thomas W; Shutter, Lori A; Baker, Dewleen G; Geracioti, Thomas D 2010. Low cerebrospinal fluid and plasma orexin-A (hypocretin-1) concentrations in combat-related posttraumatic stress disorder. Psychoneuroendocrinology, 35 7, 1001-7

Sah, Renu; Ekhator, Nosakhare N; Strawn, Jeffrey R; Sallee, Floyd R; Baker, Dewleen G; Horn, Paul S; Geracioti, Thomas D 2009. Low cerebrospinal fluid neuropeptide Y concentrations in posttraumatic stress disorder. Biological psychiatry, 66 7, 705-7

Strawn, Jeffrey R; Delbello, Melissa P; Geracioti, Thomas D 2009. Prazosin treatment of an adolescent with posttraumatic stress disorder. Journal of child and adolescent psychopharmacology, 19 5, 599-600

Geracioti, Thomas D; Baker, Dewleen G; Kasckow, John W; Strawn, Jeffrey R; Jeffrey Mulchahey, J; Dashevsky, Boris A; Horn, Paul S; Ekhator, Nosakhare N 2008. Effects of trauma-related audiovisual stimulation on cerebrospinal fluid norepinephrine and corticotropin-releasing hormone concentrations in post-traumatic stress disorder. Psychoneuroendocrinology, 33 4, 416-24

Strawn, J R; Geracioti, T D 2008. Noradrenergic dysfunction and the psychopharmacology of posttraumatic stress disorder. Depression and anxiety, 25 3, 260-71

Strawn, Jeffrey R; Dowling, Brian P; Geracioti, Thomas D 2008. Pregabalin treatment of posttraumatic stress disorder. Journal of clinical psychopharmacology, 28 5, 596-7

Strawn, Jeffrey R; Geracioti, Thomas D 2007. The treatment of generalized anxiety disorder with pregabalin, an atypical anxiolytic. Neuropsychiatric disease and treatment, 3 2, 237-43

Geracioti, Thomas D; Carpenter, Linda L; Owens, Michael J; Baker, Dewleen G; Ekhator, Nosakhare N; Horn, Paul S; Strawn, Jeffrey R; Sanacora, Gerard; Kinkead, Becky; Price, Lawrence H; Nemeroff, Charles B 2006. Elevated cerebrospinal fluid substance p concentrations in posttraumatic stress disorder and major depression. The American journal of psychiatry, 163 4, 637-43

Baker, Dewleen G; Ekhator, Nosa N; Kasckow, John W; Dashevsky, Boris; Horn, Paul S; Bednarik, Ludmila; Geracioti, Thomas D 2005. Higher levels of basal serial CSF cortisol in combat veterans with posttraumatic stress disorder. The American journal of psychiatry, 162 5, 992-4

Geracioti, Thomas D 2005. DHEA supplementation of systemic glucocorticoids for treatment of poison ivy dermatitis. International journal of dermatology, 44 11, 974-6

Gold, Philip W; Wong, Ma-Li; Goldstein, David S; Gold, Herman K; Ronsaville, Donna S; Esler, Murray; Alesci, Salvatore; Masood, Anwar; Licinio, Julio; Geracioti, Thomas D; Perini, Giulia; DeBellis, Michael D; Holmes, Courtney; Vgontzas, Alexandros N; Charney, Dennis S; Chrousos, George P; McCann, Samuel M; Kling, Mitchel A 2005. Cardiac implications of increased arterial entry and reversible 24-h central and peripheral norepinephrine levels in melancholia. Proceedings of the National Academy of Sciences of the United States of America, 102 23, 8303-8

Lee, Royce; Geracioti, Thomas D; Kasckow, John W; Coccaro, Emil F 2005. Childhood trauma and personality disorder: positive correlation with adult CSF corticotropin-releasing factor concentrations. The American journal of psychiatry, 162 5, 995-7

Kasckow, John W; Mulchahey, James J; Geracioti, Thomas D 2004. Effects of the vanilloid agonist olvanil and antagonist capsazepine on rat behaviors. Progress in neuro-psychopharmacology & biological psychiatry, 28 2, 291-5

Strawn, J R; Ekhator, N N; D'Souza, B B; Geracioti, T D 2004. Pituitary-thyroid state correlates with central dopaminergic and serotonergic activity in healthy humans. Neuropsychobiology, 49 2, 84-7

Geracioti, Thomas D; Kling, Mitchel A; Post, Robert M; Gold, Philip W 2003. Antithyroid antibody-linked symptoms in borderline personality disorder. Endocrine, 21 2, 153-8

Richtand, Neil M; Welge, Jeffrey A; Levant, Beth; Logue, Aaron D; Hayes, Scott; Pritchard, Laurel M; Geracioti, Thomas D; Coolen, Lique M; Berger, S Paul 2003. Altered behavioral response to dopamine D3 receptor agonists 7-OH-DPAT and PD 128907 following repetitive amphetamine administration. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 28 8, 1422-32

Strawn, J R; Ekhator, N N; Anthenelli, R M; Baker, D G; Maxwell, R A; Hill, K K; Geracioti, T D 2002. Intra- and inter-individual relationships between central and peripheral serotonergic activity in humans: a serial cerebrospinal fluid sampling study. Life sciences, 71 10, 1219-25

Anthenelli, R M; Maxwell, R A; Geracioti, T D; Hauger, R 2001. Stress hormone dysregulation at rest and after serotonergic stimulation among alcohol-dependent men with extended abstinence and controls. Alcoholism, clinical and experimental research, 25 5, 692-703

Baker, D G; Ekhator, N N; Kasckow, J W; Hill, K K; Zoumakis, E; Dashevsky, B A; Chrousos, G P; Geracioti, T D 2001. Plasma and cerebrospinal fluid interleukin-6 concentrations in posttraumatic stress disorder. Neuroimmunomodulation, 9 4, 209-17

Geracioti, T D; Baker, D G; Ekhator, N N; West, S A; Hill, K K; Bruce, A B; Schmidt, D; Rounds-Kugler, B; Yehuda, R; Keck, P E; Kasckow, J W 2001. CSF norepinephrine concentrations in posttraumatic stress disorder. The American journal of psychiatry, 158 8, 1227-30

Kasckow, J W; Baker, D; Geracioti, T D 2001. Corticotropin-releasing hormone in depression and post-traumatic stress disorder. Peptides, 22 5, 845-51

Kasckow, J W; Hagan, M; Mulchahey, J J; Baker, D G; Ekhator, N N; Strawn, J R; Nicholson, W; Orth, D N; Loosen, P T; Geracioti, T D 2001. The effect of feeding on cerebrospinal fluid corticotropin-releasing hormone levels in humans. Brain research, 904 2, 218-24

Mulchahey, J J; Ekhator, N N; Zhang, H; Kasckow, J W; Baker, D G; Geracioti, T D 2001. Cerebrospinal fluid and plasma testosterone levels in post-traumatic stress disorder and tobacco dependence. Psychoneuroendocrinology, 26 3, 273-85

Pisarska, M; Mulchahey, J J; Sheriff, S; Geracioti, T D; Kasckow, J W 2001. Regulation of corticotropin-releasing hormone in vitro. Peptides, 22 5, 705-12

Strawn, J R; Ekhator, N N; Geracioti, T D 2001. In-use stability of monoamine metabolites in human cerebrospinal fluid. Journal of chromatography. B, Biomedical sciences and applications, 760 2, 301-6

Pisarska, M; Mulchahey, J J; Welge, J A; Geracioti, T D; Kasckow, J W 2000. Age-related alterations in emotional behaviors and amygdalar corticotropin-releasing factor (CRF) and CRF-binding protein expression in aged Fischer 344 rats. Brain research, 877 2, 184-90

Richtand, N M; Logue, A D; Welge, J A; Perdiue, J; Tubbs, L J; Spitzer, R H; Sethuraman, G; Geracioti, T D 2000. The dopamine D3 receptor antagonist nafadotride inhibits development of locomotor sensitization to amphetamine. Brain research, 867 1-2, 239-42

Wong, M L; Kling, M A; Munson, P J; Listwak, S; Licinio, J; Prolo, P; Karp, B; McCutcheon, I E; Geracioti, T D; DeBellis, M D; Rice, K C; Goldstein, D S; Veldhuis, J D; Chrousos, G P; Oldfield, E H; McCann, S M; Gold, P W 2000. Pronounced and sustained central hypernoradrenergic function in major depression with melancholic features: relation to hypercortisolism and corticotropin-releasing hormone. Proceedings of the National Academy of Sciences of the United States of America, 97 1, 325-30

Baker, D G; West, S A; Nicholson, W E; Ekhator, N N; Kasckow, J W; Hill, K K; Bruce, A B; Orth, D N; Geracioti, T D 1999. Serial CSF corticotropin-releasing hormone levels and adrenocortical activity in combat veterans with posttraumatic stress disorder. The American journal of psychiatry, 156 4, 585-8

Geracioti, T D; Ekhator, N N; Nicholson, W E; Arndt, S; Loosen, P T; Orth, D N 1999. Intra- and inter-individual correlations between cholecystokinin and corticotropin-releasing hormone concentrations in human cerebrospinal fluid. Depression and anxiety, 10 2, 77-80

Geracioti, T D; West, S A; Baker, D G; Hill, K K; Ekhator, N N; Wortman, M D; Keck, P E; Norman, A B 1999. Low CSF concentration of a dopamine metabolite in tobacco smokers. The American journal of psychiatry, 156 1, 130-2

Hagan, M M; Havel, P J; Seeley, R J; Woods, S C; Ekhator, N N; Baker, D G; Hill, K K; Wortman, M D; Miller, A H; Gingerich, R L; Geracioti, T D 1999. Cerebrospinal fluid and plasma leptin measurements: covariability with dopamine and cortisol in fasting humans. The Journal of clinical endocrinology and metabolism, 84 10, 3579-85

Hill, K K; West, S A; Ekhator, N N; Bruce, A B; Wortman, M D; Baker, D G; Geracioti, T D 1999. The effect of lumbar puncture stress on dopamine and serotonin metabolites in human cerebrospinal fluid. Neuroscience letters, 276 1, 25-8

Kasckow, J W; Regmi, A; Sheriff, S; Mulchahey, J; Geracioti, T D 1999. Regulation of corticotropin-releasing factor messenger RNA by nicotine in an immortalized amygdalar cell line. Life sciences, 65 25, 2709-14

Baker, D G; Boat, B W; Grinvalsky, H T; Geracioti, T D 1998. Interpersonal trauma and animal-related experiences in female and male military veterans: implications for program development. Military medicine, 163 1, 20-5

Chang, K D; Keck, P E; Stanton, S P; McElroy, S L; Strakowski, S M; Geracioti, T D 1998. Differences in thyroid function between bipolar manic and mixed states. Biological psychiatry, 43 10, 730-3

Geracioti, T D; Keck, P E; Ekhator, N N; West, S A; Baker, D G; Hill, K K; Bruce, A B; Wortman, M D 1998. Continuous covariability of dopamine and serotonin metabolites in human cerebrospinal fluid. Biological psychiatry, 44 3, 228-33

Geracioti, T D; Parker, S; Lowther, N B; Wortman, M; Richtand, N M 1998. A case of treatment-refractory psychosis responsive to sertindole. Schizophrenia research, 30 1, 105-8

Baker, D G; West, S A; Orth, D N; Hill, K K; Nicholson, W E; Ekhator, N N; Bruce, A B; Wortman, M D; Keck, P E; Geracioti, T D 1997. Cerebrospinal fluid and plasma beta-endorphin in combat veterans with post-traumatic stress disorder. Psychoneuroendocrinology, 22 7, 517-29

Geracioti, T D; Loosen, P T; Ekhator, N N; Schmidt, D; Chambliss, B; Baker, D G; Kasckow, J W; Richtand, N M; Keck, P E; Ebert, M H 1997. Uncoupling of serotonergic and noradrenergic systems in depression: preliminary evidence from continuous cerebrospinal fluid sampling. Depression and anxiety, 6 3, 89-94

Geracioti, T D; Loosen, P T; Orth, D N 1997. Low cerebrospinal fluid corticotropin-releasing hormone concentrations in eucortisolemic depression. Biological psychiatry, 42 3, 165-74

Kasckow, J W; Regmi, A; Gill, P S; Parkes, D G; Geracioti, T D 1997. Regulation of corticotropin-releasing factor (CRF) messenger ribonucleic acid and CRF peptide in the amygdala: studies in primary amygdalar cultures. Endocrinology, 138 11, 4774-82

Kirwin, P D; Anderson, G M; Chappell, P B; Saberski, L; Leckman, J F; Geracioti, T D; Heninger, G R; Price, L H; McDougle, C J 1997. Assessment of diurnal variation of cerebrospinal fluid tryptophan and 5-hydroxyindoleacetic acid in healthy human females. Life sciences, 60 12, 899-907

Geracioti, T D 1995. Venlafaxine treatment of panic disorder: a case series. The Journal of clinical psychiatry, 56 9, 408-10

Geracioti, T D; Loosen, P T; Ebert, M H; Schmidt, D; Ekhator, N N 1995. Fasting and postprandial cerebrospinal fluid glucose concentrations in healthy women and in an obese binge eater. The International journal of eating disorders, 18 4, 365-9

Geracioti, T D 1994. Valproic acid treatment of episodic explosiveness related to brain injury. The Journal of clinical psychiatry, 55 9, 416-7

Geracioti, T D; Loosen, P T; Ebert, M H; Ekhator, N N; Burns, D; Nicholson, W E; Orth, D N 1994. Concentrations of corticotropin-releasing hormone, norepinephrine, MHPG, 5-hydroxyindoleacetic acid, and tryptophan in the cerebrospinal fluid of alcoholic patients: serial sampling studies. Neuroendocrinology, 60 6, 635-42

Kling, M A; DeBellis, M D; O'Rourke, D K; Listwak, S J; Geracioti, T D; McCutcheon, I E; Kalogeras, K T; Oldfield, E H; Gold, P W 1994. Diurnal variation of cerebrospinal fluid immunoreactive corticotropin-releasing hormone levels in healthy volunteers. The Journal of clinical endocrinology and metabolism, 79 1, 233-9

Kling, M A; Geracioti, T D; Licinio, J; Michelson, D; Oldfield, E H; Gold, P W 1994. Effects of electroconvulsive therapy on the CRH-ACTH-cortisol system in melancholic depression: preliminary findings. Psychopharmacology bulletin, 30 3, 489-94

De Bellis, M D; Gold, P W; Geracioti, T D; Listwak, S J; Kling, M A 1993. Association of fluoxetine treatment with reductions in CSF concentrations of corticotropin-releasing hormone and arginine vasopressin in patients with major depression. The American journal of psychiatry, 150 4, 656-7

Geracioti, T D; Nicholson, W E; Orth, D N; Ekhator, N N; Loosen, P T 1993. Cholecystokinin in human cerebrospinal fluid: concentrations, dynamics, molecular forms and relationship to fasting and feeding in health, depression and alcoholism. Brain research, 629 2, 260-8

Loosen, P T; Chambliss, B; Ekhator, N; Burns, D; Geracioti, T D; Orth, D N 1993. Thyroid and adrenal dysfunction in abstinent alcoholic men: locus of disturbance. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 9 4, 255-66

Babe, K S; Peterson, A M; Loosen, P T; Geracioti, T D 1992. The pathogenesis of Munchausen syndrome. A review and case report. General hospital psychiatry, 14 4, 273-6

Geracioti, T D; Liddle, R A; Altemus, M; Demitrack, M A; Gold, P W 1992. Regulation of appetite and cholecystokinin secretion in anorexia nervosa. The American journal of psychiatry, 149 7, 958-61

Geracioti, T D; Loosen, P T; Gold, P W; Kling, M A 1992. Cortisol, thyroid hormone, and mood in atypical depression: a longitudinal case study. Biological psychiatry, 31 5, 515-9

Geracioti, T D; Orth, D N; Ekhator, N N; Blumenkopf, B; Loosen, P T 1992. Serial cerebrospinal fluid corticotropin-releasing hormone concentrations in healthy and depressed humans. The Journal of clinical endocrinology and metabolism, 74 6, 1325-30

Geracioti, T D; Post, R M 1991. Onset of panic disorder associated with rare use of cocaine. Biological psychiatry, 29 4, 403-6

Geracioti, T D; Kling, M A; Joseph-Vanderpool, J R; Kanayama, S; Rosenthal, N E; Gold, P W; Liddle, R A 1989. Meal-related cholecystokinin secretion in eating and affective disorders. Psychopharmacology bulletin, 25 3, 444-9

Kling, M A; Perini, G I; Demitrack, M A; Geracioti, T D; Linnoila, M; Chrousos, G P; Gold, P W 1989. Stress-responsive neurohormonal systems and the symptom complex of affective illness. Psychopharmacology bulletin, 25 3, 312-8

Kling, M A; Whitfield, H J; Brandt, H A; Demitrack, M A; Kalogeras, K; Geracioti, T D; Perini, G I; Calabrese, J R; Chrousos, G P; Gold, P W 1989. Effects of glucocorticoid antagonism with RU 486 on pituitary-adrenal function in patients with major depression: time-dependent enhancement of plasma ACTH secretion. Psychopharmacology bulletin, 25 3, 466-72

Smith, M A; Kling, M A; Whitfield, H J; Brandt, H A; Demitrack, M A; Geracioti, T D; Chrousos, G P; Gold, P W 1989. Corticotropin-releasing hormone: from endocrinology to psychobiology. Hormone research, 31 1-2, 66-71

Geracioti, T D; Liddle, R A 1988. Impaired cholecystokinin secretion in bulimia nervosa. The New England journal of medicine, 319 11, 683-8

Geracioti, T D; Van Dyke, C; Mueller, J; Merrin, E 1987. The onset of Munchausen's syndrome. General hospital psychiatry, 9 6, 405-9

Geracioti, T D 1986. Biology and consciousness. Psychosomatics, 27 4, 240, 243

De Bellis, M D; Geracioti, T D; Altemus, M; Kling, M A . Cerebrospinal fluid monoamine metabolites in fluoxetine-treated patients with major depression and in healthy volunteers. Biological psychiatry, 33 8-9, 636-41

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Strawn, Jeffrey R; Ekhator, Nosakhare N; Horn, Paul S; Baker, Dewleen G; Geracioti, Thomas D . Blood pressure and cerebrospinal fluid norepinephrine in combat-related posttraumatic stress disorder. Psychosomatic medicine, 66 5, 757-9