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Photo of Caroline Billingsley, MD

Caroline Billingsley, MD

Associate Professor of Clinical

Obstetrics & Gynecology | College of Medicine

  • Fellowship: The Ohio State University Wexner Medical Center (Gynecology Oncology)
  • Residency: Medical University of South Carolina
  • Bachelor's Degree: College of Charleston (Biology, Philosophy)
Board Certifications & Licenses

American Board of Obstetrics and Gynecology (Gynecologic Oncology) (Certification Date: 2018-04-13) - (Recertification Date: 2022-12-31)
American Board of Obstetrics and Gynecology (Certification Date: 2016-11-11) - (Recertification Date: 2022-12-31)


Gynecologic Oncology
Obstetrics and Gynecology

Contact Information
Research Interests

Gynecologic Oncology, Advanced Pelvic Surgery, Minimally Invasive Surgery - Robotic Surgery, Fertility Sparing Options, Oncofertility

Clinical Interests

Gynecologic Oncology


Adnexal Disease

Adnexal Tumors

Cervical Cancer


Embryonal Carcinoma

Embryonal Tumors

Endometrial Cancer

Endometrial Stromal Sarcoma


Fallopian Tube Cancer


Germ Cell and Embryona Cancers

Germ Cell Tumor

Gestational Trophoblastic Neoplasia

Human Papilloma Virus (HPV)

Krukenberg Tumor

Other Complicated Gynecologic Cancers

Ovarian Cancer

Ovarian Cyst

Pelvic Cancers

Pelvic Masses

Placenta Accreta

Precancer in the Vagina

Precancer in the Vulva

Precancers in the Cervix

Uterine Fibroids (Uterine leiomyoma)

Uterine Hemorrhage

Uterine Polyps (Endometrial Polyps)

Uterine Sarcoma

Vaginal Cancer

Vulvar Cancer

Peer Reviewed Publications

Bedard, Mary C; Chihanga, Tafadzwa; Carlile, Adrean; Jackson, Robert; Brusadelli, Marion G; Lee, Denis; VonHandorf, Andrew; Rochman, Mark; Dexheimer, Phillip J; Chalmers, Jeffrey; Nuovo, Gerard; Lehn, Maria; Williams, David E J; Kulkarni, Aditi; Carey, Molly; Jackson, Amanda; Billingsley, Caroline; Tang, Alice; Zender, Chad; Patil, Yash; Wise-Draper, Trisha M; Herzog, Thomas J; Ferris, Robert L; Kendler, Ady; Aronow, Bruce J; Kofron, Matthew; Rothenberg, Marc E; Weirauch, Matthew T; Van Doorslaer, Koenraad; Wikenheiser-Brokamp, Kathryn A; Lambert, Paul F; Adam, Mike; Steven Potter, S; Wells, Susanne I 2023. Single cell transcriptomic analysis of HPV16-infected epithelium identifies a keratinocyte subpopulation implicated in cancer. Nature communications, 14 1, 1975

Khadraoui, Hanaa; Herzog, Thomas J; Jackson, Amanda; Billingsley, Caroline 2023. Acute pulmonary complications in the setting of high risk gestational trophoblastic neoplasia and induction of chemotherapy. Gynecologic oncology reports, 48 , 101224

Mirza, Mansoor R; Chase, Dana M; Slomovitz, Brian M; dePont Christensen, René; Novák, Zoltán; Black, Destin; Gilbert, Lucy; Sharma, Sudarshan; Valabrega, Giorgio; Landrum, Lisa M; Hanker, Lars C; Stuckey, Ashley; Boere, Ingrid; Gold, Michael A; Auranen, Annika; Pothuri, Bhavana; Cibula, David; McCourt, Carolyn; Raspagliesi, Francesco; Shahin, Mark S; Gill, Sarah E; Monk, Bradley J; Buscema, Joseph; Herzog, Thomas J; Copeland, Larry J; Tian, Min; He, Zangdong; Stevens, Shadi; Zografos, Eleftherios; Coleman, Robert L; Powell, Matthew A 2023. Dostarlimab for Primary Advanced or Recurrent Endometrial Cancer. The New England journal of medicine, 388 23, 2145-2158

Baucom, Amanda; Herzog, Thomas; Jackson, Amanda; Wahab, Shaun A; Billingsley, Caroline 2021. A case of placenta previa with increta with a history of pelvic radiation. Gynecologic oncology reports, 37 , 100800

Loreen, Amy; Polen-De, Clarissa; Monk, Bradley J; Jackson, Amanda L; Billingsley, Caroline C; Herzog, Thomas J 2021. The role of blinded independent radiologic review in ovarian cancer clinical trials: Discerning the value. Gynecologic oncology, 161 2, 491-495

Perry, Madeline F; Jackson, Amanda L; Herzog, Thomas J; Billingsley, Caroline C 2020. Early diagnosis and treatment challenges of endodermal sinus tumors: A case report. Case reports in women's health, 27 , e00198

Wolf, Jennifer L; Billingsley, Caroline C; Kendler, Ady; Jackson, Amanda L 2020. Cervical Stratified Mucin-Producing Intraepithelial Lesion: A Systematic Review of Diagnosis and Management. Journal of lower genital tract disease, 24 3, 259-264

Wolf, Jennifer; Jackson, Amanda; Herzog, Thomas; Kendler, Ady; Wahab, Shaun A; Billingsley, Caroline 2020. A case of a unique presentation of a primary vaginal endometrioid adenocarcinoma arising in the setting of a recurrent peritoneal inclusion cyst fistulized to the vagina. Gynecologic oncology reports, 33 , 100585

Billingsley, Caroline; Jackson, Amanda; Loreen, Amy 2019. 29-year-old with dyspareunia and vulvar mass: An unusual diagnosis of Bartholin's gland carcinoma. Gynecologic oncology reports, 27 , 15-18

Rothenberger, Rodger; Jackson, Amanda; Kendler, Ady; Herzog, Thomas; Billingsley, Caroline 2019. An unusual case of uterine PEComa presenting with disseminated intravascular coagulation. Gynecologic oncology reports, 29 , 76-78

Hadad, Laura K; Billingsley, Caroline C 2017. Posterior reversible encephalopathy syndrome (PRES) associated with ovarian cancer and voltage-gated potassium channel antibodies: A case report. Gynecologic oncology reports, 20 , 67-69

Backes, Floor J; Billingsley, Caroline C; Martin, Douglas D; Tierney, Brent J; Eisenhauer, Eric L; Cohn, David E; O'Malley, David M; Salani, Ritu; Copeland, Larry J; Fowler, Jeffrey M 2014. Does intra-operative radiation at the time of pelvic exenteration improve survival for patients with recurrent, previously irradiated cervical, vaginal, or vulvar cancer? Gynecologic oncology, 135 1, 95-9

Billingsley C, Foote J, Korte J, Gagliardi E, M Kohler, Creasman WT. 12-2013. Evaluation of risk factors for infectious morbidity of postoperative gynecologic oncology patients: A Time for a New Paradigm? Clinical Ovarian and other Gynecologic Cancer, ,

Salani R.;Billingsley C.;Crafton S. 12-2013. Reply: Cancer and pregnancy: An overview for obstetricians and gynecologists American Journal of Obstetrics and Gynecology, 211 1, 83

Goodfellow PJ, Billingsley CC, Lankes HA, Ali S, Cohn DE, Broaddus RD, et al. 11-2015. Combined MSI, MLH1 methylation analysis and IHC for Lynch syndrome screening for 1002 endometrial cancers from GOG210: An NRG Oncology/Gynecologic Oncology Group study Journal of Clinical Oncology, 33 36, 4301

Backes F.;Billingsley C.;Martin D.;Tierney B.;Eisenhauer E.;Cohn D.;O'Malley D.;Salani R.;Copeland L.;Fowler J. 10-2014. Does intra-operative radiation at the time of pelvic exenteration improve survival for patients with recurrent, previously irradiated cervical, vaginal, or vulvar cancer? Gynecologic Oncology, 135 1, 95-99

Huffman L.B.;Randolph L.K.;McCann G.A.;Billingsley C.;Hopkins M.;Cohn D.E.;Hundley A.F. 10-2013. Options for repair of rectus abdominis myocutaneous perineal/vaginal flap prolapse: A case series Gynecologic Oncology Case Reports, 7 , 1-3

Billingsley C.C.;Jacobson S.N.;Crafton S.M.;Crim A.K.;Li Q.;Hade E.M.;Cohn D.E.;Fowler J.M.;Copeland L.J.;Salani R.;Backes F.J.;O'Malley D.M. 09-2015. Evaluation of the Hematologic Safety of Same Day Versus Standard Administration (24- to 72-Hour Delay) of Pegfilgrastim in Gynecology Oncology Patients Undergoing Cytotoxic Chemotherapy International Journal of Gynecological Cancer, 25 7, 1331-1336

Billingsley C.;Kenne K.;Cansino C.;Backes F.;Cohn D.;O'Malley D.;Copeland L.;Fowler J.;Salani R. 06-2015. The Use of Transvaginal Ultrasound in Type II Endometrial Cancer International Journal of Gynecological Cancer, 25 5, 858-862

Dempsey A.;Billingsley C.;Savage A.;Korte J. 06-01-2012. Predictors of long-acting reversible contraception use among unmarried young adults American Journal of Obstetrics and Gynecology, 206 6, 526.e1-526.e5

Billingsley C.;Kohler M.;Creasman W.;Madory J.;Young J. 04-01-2012. A case of parametrial lymph node involvement in stage IA2 squamous cell carcinoma of the cervix trea Journal of Lower Genital Tract Disease, 16 2, 145-148

Billingsley C.;Cohn D.;Mutch D.;Stephens J.;Suarez A.;Goodfellow P. 02-2015. Polymerase ε (POLE) mutations in endometrial cancer: clinical outcomes and implications for Lynch Syndrome testing Cancer, 121 3, 386-394

Billingsley CC, O’Malley D, Hays J 02-2015. The role of anti-angiogenic therapy in the management of gynecologic malignancies: A review Journal of OncoPathology, 3 1, 77-87

Salani R.;Billingsley C.;Crafton S. 01-01-2014. Cancer and pregnancy: An overview for obstetricians and gynecologists American Journal of Obstetrics and Gynecology, 211 1, 7-14