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Photo of  Agnes Luo, PHD

Agnes Luo, PHD


Professor and Vice Chair for Research

Molecular & Cellular Biosciences | College of Medicine

  • Research Fellow: National Institute of Drug Abuse, NIH
  • Post Doctoral Fellow: National Institute of Drug Abuse, NIH
  • Ph D: University of Rochester (Molecular Toxicology)
  • Bachelor of Science: Nanjing University (Environmental Biology)
Contact Information
Research Interests

Molecular Genetics, Neuroinflammation, Neuroprotection and Regeneration, Stem Cells and Regenerative Medicine, Animal Models of Neurological Diseases.

Peer Reviewed Publications

Bedolla, Alicia M; McKinsey, Gabriel L; Ware, Kierra; Santander, Nicolas; Arnold, Thomas D; Luo, Yu 2024. A comparative evaluation of the strengths and potential caveats of the microglial inducible CreER mouse models Cell reports, 43 1, 113660

Bedolla, Alicia; Wegman, Elliot; Weed, Max; Paranjpe, Aditi; Alkhimovitch, Anastasia; Ifergan, Igal; McClain, Lucas; Luo, Yu 2023. Microglia-derived TGF-β1 ligand maintains microglia homeostasis via autocrine mechanism and is critical for normal cognitive function in adult mouse brain bioRxiv : the preprint server for biology, ,

Glotfelty, Elliot J; Hsueh, Shih-Chang; Claybourne, Quia; Bedolla, Alicia; Kopp, Katherine O; Wallace, Tonya; Zheng, Binhai; Luo, Yu; Karlsson, Tobias E; McDevitt, Ross A; Olson, Lars; Greig, Nigel H 2023. Microglial Nogo delays recovery following traumatic brain injury in mice Glia, 71 10, 2473-2494

Bedolla, Alicia; Taranov, Aleksandr; Luo, Fucheng; Wang, Jiapeng; Turcato, Flavia; Fugate, Elizabeth M; Greig, Nigel H; Lindquist, Diana M; Crone, Steven A; Goto, June; Luo, Yu 2022. Diphtheria toxin induced but not CSF1R inhibitor mediated microglia ablation model leads to the loss of CSF/ventricular spaces in vivo that is independent of cytokine upregulation Journal of neuroinflammation, 19 1, 3

Lecca, Daniela; Jung, Yoo Jin; Scerba, Michael T; Hwang, Inho; Kim, Yu Kyung; Kim, Sun; Modrow, Sydney; Tweedie, David; Hsueh, Shih-Chang; Liu, Dong; Luo, Weiming; Glotfelty, Elliot; Li, Yazhou; Wang, Jia-Yi; Luo, Yu; Hoffer, Barry J; Kim, Dong Seok; McDevitt, Ross A; Greig, Nigel H 2022. Role of chronic neuroinflammation in neuroplasticity and cognitive function: A hypothesis Alzheimer and Dementia, ,

Luo, Fucheng; Wang, Jiapeng; Zhang, Zhen; You, Zhen; Bedolla, Alicia; Okwubido-Williams, FearGod; Huang, L Frank; Silver, Jerry; Luo, Yu 2022. Inhibition of CSPG receptor PTPs promotes migration of newly born neuroblasts, axonal sprouting, and recovery from stroke Cell reports, 40 4, 111137

Turcato, Flavia Correa; Wegman, Elliot; Lu, Tao; Ferguson, Nathan; Luo, Yu 2022. Dopaminergic neurons are not a major Sonic hedgehog ligand source for striatal cholinergic or PV interneurons iScience, 25 11, 105278

Wang, Jiapeng; Ware, Kierra; Bedolla, Alicia; Allgire, Emily; Turcato, Flavia Correa; Weed, Maxwell; Sah, Renu; Luo, Yu 2022. Disruption of Sonic Hedgehog Signaling Accelerates Age-Related Neurogenesis Decline and Abolishes Stroke-Induced Neurogenesis and Leads to Increased Anxiety Behavior in Stroke Mice Translational stroke research, ,

Ware, Kierra; Wegman, Elliot; Bedolla, Alicia; Luo, Yu 2022. Major Caveats Discovered in the Genetic Cell Ablation Model Used to Study Microglia Functions Translational stroke research, ,

Boyne, Pierce; Awosika, Oluwole O; Luo, Yu 2021. Mapping the corticoreticular pathway from cortex-wide anterograde axonal tracing in the mouse Journal of neuroscience research, 99 12, 3392-3405

Gu, Yuning; Gao, Huiyun; Kim, Kihwan; Liu, Yuchi; Ramos-Estebanez, Ciro; Luo, Yu; Wang, Yunmei; Yu, Xin 2021. Dynamic oxygen-17 MRI with adaptive temporal resolution using golden-means-based 3D radial sampling. Magnetic resonance in medicine, 85 6, 3112-3124

Luo, Fucheng; Zhang, Zhen; Luo, Yu 2021. Differential Role of p53 in Oligodendrocyte Survival in Response to Various Stresses: Experimental Autoimmune Encephalomyelitis, Cuprizone Intoxication or White Matter Stroke International journal of molecular sciences, 22 23,

Luo, Fucheng; Zhang, Zhen; Barnett, Austin; Bellinger, Tania J; Turcato, Flavia; Schmidt, Kelly; Luo, Yu 2020. Cuprizone-induced demyelination under physiological and post-stroke condition leads to decreased neurogenesis response in adult mouse brain Experimental neurology, 326 , 113168

Hu, Di; Sun, Xiaoyan; Liao, Xudong; Zhang, Xinwen; Zarabi, Sara; Schimmer, Aaron; Hong, Yuning; Ford, Christopher; Luo, Yu; Qi, Xin 2019. Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity. Acta neuropathologica, 137 6, 939-960

Jin, Yongming; Barnett, Austin; Zhang, Yifan; Yu, Xin; Luo, Yu 2017. Poststroke Sonic Hedgehog Agonist Treatment Improves Functional Recovery by Enhancing Neurogenesis and Angiogenesis Stroke, 48 6, 1636-1645

Lu, Tao; Kim, Paul; Luo, Yu 2017. Tp53 gene mediates distinct dopaminergic neuronal damage in different dopaminergic neurotoxicant models. Neural regeneration research, 12 9, 1413-1417

Filichia, Emily; Hoffer, Barry; Qi, Xin; Luo, Yu 2016. Inhibition of Drp1 mitochondrial translocation provides neural protection in dopaminergic system in a Parkinson's disease model induced by MPTP Scientific reports, 6 , 32656

Guo, Xing; Sun, XiaoYan; Hu, Di; Wang, Ya-Juan; Fujioka, Hisashi; Vyas, Rajan; Chakrapani, Sudha; Joshi, Amit Umesh; Luo, Yu; Mochly-Rosen, Daria; Qi, Xin 2016. VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease Nature communications, 7 , 12646

Qi, Xin; Davis, Brandon; Chiang, Yung-Hsiao; Filichia, Emily; Barnett, Austin; Greig, Nigel H; Hoffer, Barry; Luo, Yu 2016. Dopaminergic neuron-specific deletion of p53 gene is neuroprotective in an experimental Parkinson's disease model Journal of neurochemistry, 138 5, 746-57

Sheng, Yang; Filichia, Emily; Shick, Elizabeth; Preston, Kenzie L; Phillips, Karran A; Cooperman, Leslie; Lin, Zhicheng; Tesar, Paul; Hoffer, Barry J; Luo, Yu 2016. Lower Dopamine D2 Receptor Expression Levels in Human Dopaminergic Neurons Derived From Opioid-Dependent iPSCs The American journal of psychiatry, 173 4, 429-31

Wang, Jing-Ya; Huang, Ya-Ni; Chiu, Chong-Chi; Tweedie, David; Luo, Weiming; Pick, Chaim G; Chou, Szu-Yi; Luo, Yu; Hoffer, Barry J; Greig, Nigel H; Wang, Jia-Yi 2016. Erratum to: Pomalidomide mitigates neuronal loss, neuroinflammation, and behavioral impairments induced by traumatic brain injury in rat. Journal of neuroinflammation, 13 1, 228

Wang, Jin-Ya; Huang, Ya-Ni; Chiu, Chong-Chi; Tweedie, David; Luo, Weiming; Pick, Chaim G; Chou, Szu-Yi; Luo, Yu; Hoffer, Barry J; Greig, Nigel H; Wang, Jia-Yi 2016. Pomalidomide mitigates neuronal loss, neuroinflammation, and behavioral impairments induced by traumatic brain injury in rat Journal of neuroinflammation, 13 1, 168

Yang, Ling-Yu; Greig, Nigel H; Huang, Ya-Ni; Hsieh, Tsung-Hsun; Tweedie, David; Yu, Qian-Sheng; Hoffer, Barry J; Luo, Yu; Kao, Yu-Chieh; Wang, Jia-Yi 2016. Post-traumatic administration of the p53 inactivator pifithrin-O oxygen analogue reduces hippocampal neuronal loss and improves cognitive deficits after experimental traumatic brain injury Neurobiology of disease, 96 , 216-226

Yu Luo, Hui Shen, Hua‐Shan Liu, Seong‐Jin Yu, David Reiner, Brandon K. Harvey, Barry J. Hoffer, Yihong Yang, and Yun Wang 2013. CART peptide induces neuroregeneration in stroke rats Journal of Cerebral Blood Flow and Metabolism , 33 2, 300-10

Yu Luo, Chi-Chung Kuo, Hui Shen, Jenny Chou, Nigel H. Greig, Barry J. Hoffer, Yun Wang 2009. Delayed treatment with a p53 inhibitor enhances functional recovery in stroke brain Ann Neurol, 65 5, 520-30

Yu Luo, Feng Xing, Rita Guiliano, Howard J. Federoff 2008. Identification of a novel Nurr1 interacting protein J Neurosci, 28 37, 9277-86