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Photo of Rhett Kovall, Ph.D.

Rhett Kovall, Ph.D.

Professor (F3)

COM Mol Gen Kovall Lab

Education/Credentials
  • B.A.: University of Colorado
  • Ph.D.: University of Oregon, Institute of Molecular Biology
  • Post Doc: Columbia University
Research Interests

My research interests involve understanding at the molecular level how transcription is regulated in the Notch signaling pathway. The Notch pathway is a highly conserved cell-to-cell signaling mechanism in metazoans that is essential for embryonic develop...

Contact Information
  • University of Cincinnati College of Medicine
  • Department of Molecular Genetics, Biochemistry and Microbiology
  • 231 Albert Sabin Way MSB2201
  • Cincinnati, Ohio 45267-0524
  • Office 513-558-4631
  • Email rhett.kovall@uc.edu

Peer Reviewed Publications

Miesfeld, Joel B; Moon, Myung-Soon; Riesenberg, Amy N; Contreras, Ashley N; Kovall, Rhett A; Brown, Nadean L 2018. Rbpj direct regulation of Atoh7 transcription in the embryonic mouse retina. Scientific reports, 8 1, 10195

Oswald, Franz; Kovall, Rhett A 2018. CSL-Associated Corepressor and Coactivator Complexes. Advances in experimental medicine and biology, 1066 , 279-295

Kovall, Rhett A; Gebelein, Brian; Sprinzak, David; Kopan, Raphael 2017. The Canonical Notch Signaling Pathway: Structural and Biochemical Insights into Shape, Sugar, and Force. Developmental cell, 41 3, 228-241

Nagel, Anja C; Auer, Jasmin S; Schulz, Adriana; Pfannstiel, Jens; Yuan, Zhenyu; Collins, Courtney E; Kovall, Rhett A; Preiss, Anette 2017. Phosphorylation of Suppressor of Hairless impedes its DNA-binding activity. Scientific reports, 7 1, 11820

Tabaja, Nassif; Yuan, Zhenyu; Oswald, Franz; Kovall, Rhett A 2017. Structure-function analysis of RBPJ-interacting and tubulin-associated (RITA) reveals regions critical for repression of Notch target genes. The Journal of biological chemistry, ,

Xu, Tao; Park, Sung-Soo; Giaimo, Benedetto Daniele; Hall, Daniel; Ferrante, Francesca; Ho, Diana M; Hori, Kazuya; Anhezini, Lucas; Ertl, Iris; Bartkuhn, Marek; Zhang, Honglai; Milon, Eléna; Ha, Kimberly; Conlon, Kevin P; Kuick, Rork; Govindarajoo, Brandon; Zhang, Yang; Sun, Yuqing; Dou, Yali; Basrur, Venkatesha; Elenitoba-Johnson, Kojo Sj; Nesvizhskii, Alexey I; Ceron, Julian; Lee, Cheng-Yu; Borggrefe, Tilman; Kovall, Rhett A; Rual, Jean-François 2017. RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1. The EMBO journal, 36 21, 3232-3249

Oswald, Franz; Rodriguez, Patrick; Giaimo, Benedetto Daniele; Antonello, Zeus A; Mira, Laura; Mittler, Gerhard; Thiel, Verena N; Collins, Kelly J; Tabaja, Nassif; Cizelsky, Wiebke; Rothe, Melanie; Kühl, Susanne J; Kühl, Michael; Ferrante, Francesca; Hein, Kerstin; Kovall, Rhett A; Dominguez, Maria; Borggrefe, Tilman 2016. A phospho-dependent mechanism involving NCoR and KMT2D controls a permissive chromatin state at Notch target genes. Nucleic acids research, 44 10, 4703-20

Yuan, Zhenyu; Praxenthaler, Heiko; Tabaja, Nassif; Torella, Rubben; Preiss, Anette; Maier, Dieter; Kovall, Rhett A 2016. Structure and Function of the Su(H)-Hairless Repressor Complex, the Major Antagonist of Notch Signaling in Drosophila melanogaster. PLoS biology, 14 7, e1002509

Contreras, Ashley N; Yuan, Zhenyu; Kovall, Rhett A 2015. Thermodynamic binding analysis of Notch transcription complexes from D. melanogaster. Protein science : a publication of the Protein Society, ,

Collins, Kelly J; Yuan, Zhenyu; Kovall, Rhett A 2014. Structure and function of the CSL-KyoT2 corepressor complex: a negative regulator of notch signaling. Structure (London, England : 1993), 22 1, 70-81

Su, Shengchang; Panmanee, Warunya; Wilson, Jeffrey J; Mahtani, Harry K; Li, Qian; Vanderwielen, Bradley D; Makris, Thomas M; Rogers, Melanie; McDaniel, Cameron; Lipscomb, John D; Irvin, Randall T; Schurr, Michael J; Lancaster, Jack R; Kovall, Rhett A; Hassett, Daniel J 2014. Catalase (KatA) plays a role in protection against anaerobic nitric oxide in Pseudomonas aeruginosa. PloS one, 9 3, e91813

Torella, Rubben; Li, Jinghua; Kinrade, Eddie; Cerda-Moya, Gustavo; Contreras, Ashley N; Foy, Robert; Stojnic, Robert; Glen, Robert C; Kovall, Rhett A; Adryan, Boris; Bray, Sarah J 2014. A combination of computational and experimental approaches identifies DNA sequence constraints associated with target site binding specificity of the transcription factor CSL. Nucleic acids research, 42 16, 10550-63

Kovall, Rhett A 2012. In notch, one ANK repeat is not like the other. Structure (London, England : 1993), 20 2, 202-4

Yuan, Zhenyu; Friedmann, David R; Vanderwielen, Bradley D; Collins, Kelly J; Kovall, Rhett A 2012. Characterization of CSL (CBF-1, Su(H), Lag-1) Mutants Reveals Differences in Signaling Mediated by Notch1 and Notch2. The Journal of biological chemistry, 287 42, 34904-16

Bahassi, El Mustapha; Yin, Moying; Robbins, Susan B; Li, Ya-Qin; Conrady, Deborah G; Yuan, Zhenyu; Kovall, Rhett A; Herr, Andrew B; Stambrook, Peter J 2011. A human cancer-predisposing polymorphism in Cdc25A is embryonic lethal in the mouse and promotes ASK-1 mediated apoptosis. Cell division, 6 1, 4

Kurth, Patricia; Preiss, Anette; Kovall, Rhett A; Maier, Dieter 2011. Molecular analysis of the notch repressor-complex in Drosophila: characterization of potential hairless binding sites on suppressor of hairless. PloS one, 6 11, e27986

Maier, Dieter; Kurth, Patricia; Schulz, Adriana; Russell, Andrew; Yuan, Zhenyu; Gruber, Kim; Kovall, Rhett A; Preiss, Anette 2011. Structural and functional analysis of the repressor complex in the Notch signaling pathway of Drosophila melanogaster. Molecular biology of the cell, 22 17, 3242-52

VanderWielen, Bradley D; Yuan, Zhenyu; Friedmann, David R; Kovall, Rhett A 2011. Transcriptional repression in the Notch pathway: thermodynamic characterization of CSL-MINT (Msx2-interacting nuclear target protein) complexes. The Journal of biological chemistry, 286 17, 14892-902

Conrady, Deborah G; Flagler, Michael J; Friedmann, David R; Vander Wielen, Bradley D; Kovall, Rhett A; Weiss, Alison A; Herr, Andrew B 2010. Molecular basis of differential B-pentamer stability of Shiga toxins 1 and 2. PloS one, 5 12, e15153

Friedmann, David R; Kovall, Rhett A 2010. Thermodynamic and structural insights into CSL-DNA complexes. Protein science : a publication of the Protein Society, 19 1, 34-46

Kovall, Rhett A; Blacklow, Stephen C 2010. Mechanistic insights into Notch receptor signaling from structural and biochemical studies. Current topics in developmental biology, 92 , 31-71

Friedmann, David R; Wilson, Jeffrey J; Kovall, Rhett A 2008. RAM-induced allostery facilitates assembly of a notch pathway active transcription complex. The Journal of biological chemistry, 283 21, 14781-91

Kovall, R A 2008. More complicated than it looks: assembly of Notch pathway transcription complexes. Oncogene, 27 38, 5099-109

Kovall, Rhett A 2007. Structures of CSL, Notch and Mastermind proteins: piecing together an active transcription complex. Current opinion in structural biology, 17 1, 117-27

Wilson, Jeffrey J; Kovall, Rhett A 2006. Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA. Cell, 124 5, 985-96

Kovall, Rhett A; Hendrickson, Wayne A 2004. Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNA. The EMBO journal, 23 17, 3441-51

Min, K Christopher; Kovall, Rhett A; Hendrickson, Wayne A 2003. Crystal structure of human alpha-tocopherol transfer protein bound to its ligand: implications for ataxia with vitamin E deficiency. Proceedings of the National Academy of Sciences of the United States of America, 100 25, 14713-8

Kovall, R A; Matthews, B W 1999. Type II restriction endonucleases: structural, functional and evolutionary relationships. Current opinion in chemical biology, 3 5, 578-83

Kovall, R A; Matthews, B W 1998. Structural, functional, and evolutionary relationships between lambda-exonuclease and the type II restriction endonucleases. Proceedings of the National Academy of Sciences of the United States of America, 95 14, 7893-7

Rhett Kovall and Brian W. Matthews 1997. Toroidal Structure of Lambda-Exonuclease Science, 277 5333, 1824-1827