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Photo of  Jack Rubinstein, MD

Jack Rubinstein, MD

Associate Professor of Clinical

Internal Medicine | College of Medicine

  • Medical Degree: Universidad Anahuac del Norte - Honors
  • Research Fellowship: Instituto Nacional de Cardiologia Ignacio Chavez
  • Residency: Albert Einstein Medical Center
  • Chief Medical Resident : Thomas Jefferson University - Frankford Campus
  • Fellowship : Michigan State University
  • Chief Fellow : Michigan State University
Board Certifications & Licenses

American Board of Internal Medicine (Cardiovascular Disease) (Certification Date: 20091106)

Clinical Interest

Cardiovascular Disease


Cardiovascular Disease
Internal Medicine

Research Interests

Advanced Echocardiographic Imaging, Myocardial Energy Utilization.

Contact Information

Peer Reviewed Publications

Lam, Chi Keung; Zhao, Wen; Cai, Wenfeng; Vafiadaki, Elizabeth; Florea, Stela M; Ren, Xiaoping; Liu, Yong; Robbins, Nathan; Zhang, Zhiguo; Zhou, Xiaoyang; Jiang, Min; Rubinstein, Jack; Jones, W Keith; Kranias, Evangelia G 2013. Novel role of HAX-1 in ischemic injury protection involvement of heat shock protein 90. Circulation research, 112 1, 79-89

Robbins, Nathan; Koch, Sheryl E; Rubinstein, Jack 2013. Targeting TRPV1 and TRPV2 for potential therapeutic interventions in cardiovascular disease. Translational research : the journal of laboratory and clinical medicine, ,

Yan, Sujuan; Song, Weizhong; Chen, Yamei; Hong, Kui; Rubinstein, Jack; Wang, Hong-Sheng 2013. Low-dose bisphenol A and estrogen increase ventricular arrhythmias following ischemia-reperfusion in female rat hearts. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 56C , 75-80

Chen, Lijuan; Ashraf, Muhammad; Wang, Yingjie; Zhou, Mi; Zhang, John; Qin, Gangjian; Rubinstein, Jack; Weintraub, Neal L; Tang, Yaoliang 2012. The role of notch 1 activation in cardiosphere derived cell differentiation. Stem cells and development, 21 12, 2122-9

Florea, Stela; Anjak, Ahmad; Cai, Wen-Feng; Qian, Jiang; Vafiadaki, Elizabeth; Figueria, Sarah; Haghighi, Kobra; Rubinstein, Jack; Lorenz, John; Kranias, Evangelia G 2012. Constitutive phosphorylation of inhibitor-1 at Ser67 and Thr75 depresses calcium cycling in cardiomyocytes and leads to remodeling upon aging. Basic research in cardiology, 107 5, 279

Haghighi, Kobra; Pritchard, Tracy; Bossuyt, Julie; Waggoner, Jason R; Yuan, Qunying; Fan, Guo-Chang; Osinska, Hanna; Anjak, Ahmad; Rubinstein, Jack; Robbins, Jeffrey; Bers, Donald M; Kranias, Evangelia G 2012. The human phospholamban Arg14-deletion mutant localizes to plasma membrane and interacts with the Na/K-ATPase. Journal of molecular and cellular cardiology, 52 3, 773-82

Koch, Sheryl E; Gao, Xiaoqian; Haar, Lauren; Jiang, Min; Lasko, Valerie M; Robbins, Nathan; Cai, Wenfeng; Brokamp, Cole; Varma, Priyanka; Tranter, Michael; Liu, Yong; Ren, Xiaoping; Lorenz, John N; Wang, Hong-Sheng; Jones, W Keith; Rubinstein, Jack 2012. Probenecid: novel use as a non-injurious positive inotrope acting via cardiac TRPV2 stimulation. Journal of molecular and cellular cardiology, 53 1, 134-44

Koch, Sheryl E; Tranter, Michael; Robbins, Nathan; Luther, Kristin; Singh, Umesh; Jiang, Min; Ren, Xiaoping; Tee, Trisha; Smith, Leah; Varma, Priyanka; Jones, W Keith; Rubinstein, Jack 2012. Probenecid as a Noninjurious Positive Inotrope in an Ischemic Heart Disease Murine Model. Journal of cardiovascular pharmacology and therapeutics, ,

Robbins, Nathan; Koch, Sheryl E; Tranter, Michael; Rubinstein, Jack 2012. The history and future of probenecid. Cardiovascular toxicology, 12 1, 1-9

Gadeela, Nitesh; Rubinstein, Jack; Tamhane, Umesh; Huang, Ruiping; Pathak, Dorothy R; Hosein, Hazel-Ann; Rich, Michael; Dhar, Gaurav; Abela, George S 2011. The impact of circulating cholesterol crystals on vasomotor function implications for no-reflow phenomenon. JACC. Cardiovascular interventions, 4 5, 521-9

Lather, Navneet; Efeovbokhan, Nephertiti; Hakeem, Abdul; Kotaru, Pavan; Abela, George S; Burger, Andrew J; Rubinstein, Jack 2011. Advanced echocardiographic imaging to predict exercise capacity in relatively healthy women. International journal of cardiology, 151 3, 369-71

Patel, Roshan; Janoudi, Abed; Vedre, Ameeth; Aziz, Kusai; Tamhane, Umesh; Rubinstein, Jack; Abela, Oliver G; Berger, Kevin; Abela, George S 2011. Plaque rupture and thrombosis are reduced by lowering cholesterol levels and crystallization with ezetimibe and are correlated with fluorodeoxyglucose positron emission tomography. Arteriosclerosis, thrombosis, and vascular biology, 31 9, 2007-14

Pelosi, Augusta; St John, Linda; Gaymer, Jean; Ferguson, Danielle; Goyal, Sandeep K; Abela, George S; Rubinstein, Jack 2011. Cardiac tissue Doppler and tissue velocity imaging in anesthetized new zealand white rabbits. Journal of the American Association for Laboratory Animal Science : JAALAS, 50 3, 317-21

Huang, Wei; Rubinstein, Jack; Prieto, Alejandro R; Wang, Donna H 2010. Enhanced postmyocardial infarction fibrosis via stimulation of the transforming growth factor-beta-Smad2 signaling pathway: role of transient receptor potential vanilloid type 1 channels. Journal of hypertension, 28 2, 367-76

Huang, Wei; Rubinstein, Jack; Prieto, Alejandro R; Thang, Loc Vinh; Wang, Donna H 2009. Transient receptor potential vanilloid gene deletion exacerbates inflammation and atypical cardiac remodeling after myocardial infarction. Hypertension, 53 2, 243-50

Rubinstein, Jack; Aloka, Feras; Abela, George S 2009. Statin therapy decreases myocardial function as evaluated via strain imaging. Clinical cardiology, 32 12, 684-9

Rubinstein, Jack; Dhoble, Abhijeet; Ferenchick, Gary 2009. Puzzle based teaching versus traditional instruction in electrocardiogram interpretation for medical students--a pilot study. BMC medical education, 9 , 4

Rubinstein, Jack; Pelosi, Augusta; Vedre, Ameeth; Kotaru, Pavan; Abela, George S 2009. Hypercholesterolemia and myocardial function evaluated via tissue doppler imaging. Cardiovascular ultrasound, 7 , 56

Tanaka, Tomoko; Ling, Benjamin C; Rubinstein, Jack H; Crone, Kerry R 2006. Rubinstein-Taybi syndrome in children with tethered spinal cord. Journal of neurosurgery, 105 4 Suppl, 261-4

Rubinstein, Jack 2005. Amiodarone versus sotalol for atrial fibrillation. The New England journal of medicine, 353 6, 627-30; author reply

Wiley, Susan; Swayne, Susan; Rubinstein, Jack H; Lanphear, Nancy E; Stevens, Cathy A 2003. Rubinstein-Taybi syndrome medical guidelines. American journal of medical genetics. Part A, 119A 2, 101-10

Naimi, David R; Munoz, Jose; Rubinstein, Jack; Hostoffer, Robert W . Rubinstein-Taybi syndrome: an immune deficiency as a cause for recurrent infections. Allergy and asthma proceedings : the official journal of regional and state allergy societies, 27 3, 281-4

Rubinstein, Jack; Moghe, Rohit; Mizrachi, Alberto; Dissin, Jonathan . Triptan use preceding life-threatening arrhythmias in charcot-marie-tooth: a case report and review of the literature. Clinical neuropharmacology, 27 1, 14-6