Education/CredentialsMaster of Science: University of CincinnatiBachelor of Science: University of CincinnatiDO: Ohio University Heritage College of Osteopathic Medicine Contact Information Medical Sciences Building Office 513-558-4231 Email robbinnn@ucmail.uc.edu Research InterestsCardiovascular Disease; Mechanisms underlying Heart Failure progression; Cardiac function; Translational Research; Clinical Trials; Basic Science; Echocardiography; Drug Development Peer Reviewed Publications Rubinstein, Jack; Robbins, Nathan; Evans, Karen; Foster, Gabrielle; Mcconeghy, Kevin; Onadeko, Toluwalope; Bunke, Julie; Parent, Melanie; Luo, Xi; Joseph, Jacob; Wu, Wen-Chih 2022. Repurposing Probenecid for the Treatment of Heart Failure (Re-Prosper-HF): a study protocol for a randomized placebo-controlled clinical trial. Trials, 23 1, 266Kirschner, Akiva; Koch, Sheryl E; Robbins, Nathan; Karthik, Felix; Mudigonda, Parvathi; Ramasubramanian, Ranjani; Nieman, Michelle L; Lorenz, John N; Rubinstein, Jack 2021. Pharmacologic Inhibition of Pain Response to Incomplete Vascular Occlusion Blunts Cardiovascular Preconditioning Response. Cardiovascular toxicology, 21 11, 889-900Li, Yutian; Deng, Shan; Wang, Xiaohong; Huang, Wei; Chen, Jing; Robbins, Nathan; Mu, Xingjiang; Essandoh, Kobina; Peng, Tianqing; Jegga, Anil G; Rubinstein, Jack; Adams, David E; Wang, Yigang; Peng, Jiangtong; Fan, Guo-Chang 2021. Sectm1a deficiency aggravates inflammation-triggered cardiac dysfunction through disruption of LXRα signalling in macrophages. Cardiovascular research, 117 3, 890-902O'Connor, Brian; Robbins, Nathan; Koch, Sheryl E; Rubinstein, Jack 2021. TRPV2 channel-based therapies in the cardiovascular field. Molecular underpinnings of clinically relevant therapies. Progress in biophysics and molecular biology, 159 , 118-125Horimatsu, Tetsuo; Blomkalns, Andra L; Ogbi, Mourad; Moses, Mary; Kim, David; Patel, Sagar; Gilreath, Nicole; Reid, Lauren; Benson, Tyler W; Pye, Jonathan; Ahmadieh, Samah; Thompson, Allie; Robbins, Nathan; Mann, Adrien; Edgell, Ashlee; Benjamin, Stephanie; Stansfield, Brian K; Huo, Yuqing; Fulton, David J; Agarwal, Gautam; Singh, Nagendra; Offermanns, Stefan; Weintraub, Neal L; Kim, Ha Won 2020. Niacin protects against abdominal aortic aneurysm formation via GPR109A independent mechanisms: role of NAD+/nicotinamide. Cardiovascular research, 116 14, 2226-2238Onusko, Evan; McDermott, Michael R; Robbins, Nathan; Liu, Guansheng; Kranias, Evangelia G; Rubinstein, Jack; Koch, Sheryl E 2020. Probenecid treatment improves outcomes in a novel mouse model of peripartum cardiomyopathy. PloS one, 15 3, e0230386Gardner, George T; Travers, Joshua G; Qian, Jiang; Liu, Guan-Sheng; Haghighi, Kobra; Robbins, Nathan; Jiang, Min; Li, Yutian; Fan, Guo-Chang; Rubinstein, Jack; Blaxall, Burns C; Kranias, Evangelia G 2019. Phosphorylation of Hsp20 Promotes Fibrotic Remodeling and Heart Failure. JACC. Basic to translational science, 4 2, 188-199Green, Lisa C; Anthony, Sarah R; Slone, Samuel; Lanzillotta, Lindsey; Nieman, Michelle L; Wu, Xiaoqing; Robbins, Nathan; Jones, Shannon M; Roy, Sudeshna; Owens, A Phillip; Aube, Jeffrey; Xu, Liang; Lorenz, John N; Blaxall, Burns C; Rubinstein, Jack; Benoit, Joshua B; Tranter, Michael 2019. Human antigen R as a therapeutic target in pathological cardiac hypertrophy. JCI insight, 4 4, Robbins, Nathan; Hooker, Edmond A; Hart, Kim W; Kapur, Sangita; Blomkalns, Andra 2019. Computed tomographic quantification of periaortic adipose tissue volume as a correlate of cardiovascular disease. Cardiology journal, 26 6, 802-804Daly, Patrick; Kayse, Regina; Rudick, Steven; Robbins, Nathan; Scheler, Jennifer; Harris, David; O'Donnell, Robert; Dwivedi, Alok K; Gerson, Myron C 2018. Feasibility and safety of exercise stress testing using an anti-gravity treadmill with Tc-99m tetrofosmin single-photon emission computed tomography (SPECT) myocardial perfusion imaging: A pilot non-randomized controlled study. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 25 4, 1092-1097Jones, Shannon M; Mann, Adrien; Conrad, Kelsey; Saum, Keith; Hall, David E; McKinney, Lisa M; Robbins, Nathan; Thompson, Joel; Peairs, Abigail D; Camerer, Eric; Rayner, Katey J; Tranter, Michael; Mackman, Nigel; Owens, A Phillip 2018. PAR2 (Protease-Activated Receptor 2) Deficiency Attenuates Atherosclerosis in Mice. Arteriosclerosis, thrombosis, and vascular biology, 38 6, 1271-1282Koch, Sheryl E; Nieman, Michelle L; Robbins, Nathan; Slone, Samuel; Worley, Mariah; Green, Lisa C; Chen, Yamei; Barlow, Alexandria; Tranter, Michael; Wang, HongSheng; Lorenz, John N; Rubinstein, Jack 2018. Tranilast Blunts the Hypertrophic and Fibrotic Response to Increased Afterload Independent of Cardiomyocyte Transient Receptor Potential Vanilloid 2 Channels. Journal of cardiovascular pharmacology, 72 1, 40-48Liu, Guan-Sheng; Gardner, George; Adly, George; Jiang, Min; Cai, Wen-Feng; Lam, Chi Keung; Alogaili, Fawzi; Robbins, Nathan; Rubinstein, Jack; Kranias, Evangelia G 2018. A novel human S10F-Hsp20 mutation induces lethal peripartum cardiomyopathy. Journal of cellular and molecular medicine, 22 8, 3911-3919Owens, A Phillip; Robbins, Nathan; Saum, Keith; Jones, Shannon M; Kirschner, Akiva; Woo, Jessica G; McCoy, Connie; Slone, Samuel; Rothenberg, Marc E; Urbina, Elaine M; Tranter, Michael; Rubinstein, Jack 2018. Tefillin use induces remote ischemic preconditioning pathways in healthy men. American journal of physiology. Heart and circulatory physiology, 315 6, H1748-H1758Robbins, Nathan; Gilbert, Mark; Kumar, Mohit; McNamara, James W; Daly, Patrick; Koch, Sheryl E; Conway, Ginger; Effat, Mohamed; Woo, Jessica G; Sadayappan, Sakthivel; Rubinstein, Jack 2018. Probenecid Improves Cardiac Function in Patients With Heart Failure With Reduced Ejection Fraction In Vivo and Cardiomyocyte Calcium Sensitivity In Vitro. Journal of the American Heart Association, 7 2, Jones, Shannon; Mann, Adrien; Worley, Mariah C; Fulford, Logan; Hall, David; Karani, Rajiv; Jiang, Min; Robbins, Nathan; Rubinstein, Jack; Koch, Sheryl E 2017. The role of transient receptor potential vanilloid 2 channel in cardiac aging. Aging clinical and experimental research, 29 5, 863-873Koch, Sheryl E; Mann, Adrien; Jones, Shannon; Robbins, Nathan; Alkhattabi, Abdullah; Worley, Mariah C; Gao, Xu; Lasko-Roiniotis, Valerie M; Karani, Rajiv; Fulford, Logan; Jiang, Min; Nieman, Michelle; Lorenz, John N; Rubinstein, Jack 2017. Transient receptor potential vanilloid 2 function regulates cardiac hypertrophy via stretch-induced activation. Journal of hypertension, 35 3, 602-611Naticchioni, Mindi; Karani, Rajiv; Smith, Margaret A; Onusko, Evan; Robbins, Nathan; Jiang, Min; Radzyukevich, Tatiana; Fulford, Logan; Gao, Xu; Apel, Ryan; Heiny, Judith; Rubinstein, Jack; Koch, Sheryl E 2015. Transient Receptor Potential Vanilloid 2 Regulates Myocardial Response to Exercise. PloS one, 10 9, e0136901Mann, Adrien; Thompson, Allie; Robbins, Nathan; Blomkalns, Andra L 2014. Localization, identification, and excision of murine adipose depots. Journal of visualized experiments : JoVE, 94, Robbins, Nathan; Thompson, Allie; Mann, Adrien; Blomkalns, Andra L 2014. Isolation and excision of murine aorta; a versatile technique in the study of cardiovascular disease. Journal of visualized experiments : JoVE, 93, e52172Rubinstein, Jack; Lasko, Valerie M; Koch, Sheryl E; Singh, Vivek P; Carreira, Vinicius; Robbins, Nathan; Patel, Amit R; Jiang, Min; Bidwell, Philip; Kranias, Evangelia G; Jones, W Keith; Lorenz, John N 2014. Novel role of transient receptor potential vanilloid 2 in the regulation of cardiac performance. American journal of physiology. Heart and circulatory physiology, 306 4, H574-84Basford, Joshua E; Koch, Sheryl; Anjak, Ahmad; Singh, Vivek P; Krause, Eric G; Robbins, Nathan; Weintraub, Neal L; Hui, David Y; Rubinstein, Jack 2013. Smooth muscle LDL receptor-related protein-1 deletion induces aortic insufficiency and promotes vascular cardiomyopathy in mice. PloS one, 8 11, e82026Koch, Sheryl E; Haworth, Kevin J; Robbins, Nathan; Smith, Margaret A; Lather, Navneet; Anjak, Ahmad; Jiang, Min; Varma, Priyanka; Jones, W Keith; Rubinstein, Jack 2013. Age- and gender-related changes in ventricular performance in wild-type FVB/N mice as evaluated by conventional and vector velocity echocardiography imaging: a retrospective study. Ultrasound in medicine & biology, 39 11, 2034-43Koch, Sheryl E; Tranter, Michael; Robbins, Nathan; Luther, Kristin; Singh, Umesh; Jiang, Min; Ren, Xiaoping; Tee, Trisha; Smith, Leah; Varma, Priyanka; Jones, W Keith; Rubinstein, Jack 2013. Probenecid as a noninjurious positive inotrope in an ischemic heart disease murine model. Journal of cardiovascular pharmacology and therapeutics, 18 3, 280-9Lam CK, Zhao W, Cai W, Vafiadaki E, Florea SM, Ren X, Liu Y, Robbins N, Zhang Z, Zhou X, Jiang M, Rubinstein J, Jones WK, and Kranias EG 2013. Novel Role of HAX-1 in Ischemic Injury Protection: Involvement of Hsp90 Circulation Research, 112 1, 79Robbins, Nathan; Koch, Sheryl E; Rubinstein, Jack 2013. Targeting TRPV1 and TRPV2 for potential therapeutic interventions in cardiovascular disease. Translational research : the journal of laboratory and clinical medicine, 161 6, 469-76Koch, Sheryl E; Gao, Xiaoqian; Haar, Lauren; Jiang, Min; Lasko, Valerie M; Robbins, Nathan; Cai, Wenfeng; Brokamp, Cole; Varma, Priyanka; Tranter, Michael; Liu, Yong; Ren, Xiaoping; Lorenz, John N; Wang, Hong-Sheng; Jones, W Keith; Rubinstein, Jack 2012. Probenecid: novel use as a non-injurious positive inotrope acting via cardiac TRPV2 stimulation. Journal of molecular and cellular cardiology, 53 1, 134-44Robbins, Nathan; Koch, Sheryl E; Tranter, Michael; Rubinstein, Jack 2012. The history and future of probenecid. Cardiovascular toxicology, 12 1, 1-9
Research InterestsCardiovascular Disease; Mechanisms underlying Heart Failure progression; Cardiac function; Translational Research; Clinical Trials; Basic Science; Echocardiography; Drug Development
Peer Reviewed Publications Rubinstein, Jack; Robbins, Nathan; Evans, Karen; Foster, Gabrielle; Mcconeghy, Kevin; Onadeko, Toluwalope; Bunke, Julie; Parent, Melanie; Luo, Xi; Joseph, Jacob; Wu, Wen-Chih 2022. Repurposing Probenecid for the Treatment of Heart Failure (Re-Prosper-HF): a study protocol for a randomized placebo-controlled clinical trial. Trials, 23 1, 266Kirschner, Akiva; Koch, Sheryl E; Robbins, Nathan; Karthik, Felix; Mudigonda, Parvathi; Ramasubramanian, Ranjani; Nieman, Michelle L; Lorenz, John N; Rubinstein, Jack 2021. Pharmacologic Inhibition of Pain Response to Incomplete Vascular Occlusion Blunts Cardiovascular Preconditioning Response. Cardiovascular toxicology, 21 11, 889-900Li, Yutian; Deng, Shan; Wang, Xiaohong; Huang, Wei; Chen, Jing; Robbins, Nathan; Mu, Xingjiang; Essandoh, Kobina; Peng, Tianqing; Jegga, Anil G; Rubinstein, Jack; Adams, David E; Wang, Yigang; Peng, Jiangtong; Fan, Guo-Chang 2021. Sectm1a deficiency aggravates inflammation-triggered cardiac dysfunction through disruption of LXRα signalling in macrophages. Cardiovascular research, 117 3, 890-902O'Connor, Brian; Robbins, Nathan; Koch, Sheryl E; Rubinstein, Jack 2021. TRPV2 channel-based therapies in the cardiovascular field. Molecular underpinnings of clinically relevant therapies. Progress in biophysics and molecular biology, 159 , 118-125Horimatsu, Tetsuo; Blomkalns, Andra L; Ogbi, Mourad; Moses, Mary; Kim, David; Patel, Sagar; Gilreath, Nicole; Reid, Lauren; Benson, Tyler W; Pye, Jonathan; Ahmadieh, Samah; Thompson, Allie; Robbins, Nathan; Mann, Adrien; Edgell, Ashlee; Benjamin, Stephanie; Stansfield, Brian K; Huo, Yuqing; Fulton, David J; Agarwal, Gautam; Singh, Nagendra; Offermanns, Stefan; Weintraub, Neal L; Kim, Ha Won 2020. Niacin protects against abdominal aortic aneurysm formation via GPR109A independent mechanisms: role of NAD+/nicotinamide. Cardiovascular research, 116 14, 2226-2238Onusko, Evan; McDermott, Michael R; Robbins, Nathan; Liu, Guansheng; Kranias, Evangelia G; Rubinstein, Jack; Koch, Sheryl E 2020. Probenecid treatment improves outcomes in a novel mouse model of peripartum cardiomyopathy. PloS one, 15 3, e0230386Gardner, George T; Travers, Joshua G; Qian, Jiang; Liu, Guan-Sheng; Haghighi, Kobra; Robbins, Nathan; Jiang, Min; Li, Yutian; Fan, Guo-Chang; Rubinstein, Jack; Blaxall, Burns C; Kranias, Evangelia G 2019. Phosphorylation of Hsp20 Promotes Fibrotic Remodeling and Heart Failure. JACC. Basic to translational science, 4 2, 188-199Green, Lisa C; Anthony, Sarah R; Slone, Samuel; Lanzillotta, Lindsey; Nieman, Michelle L; Wu, Xiaoqing; Robbins, Nathan; Jones, Shannon M; Roy, Sudeshna; Owens, A Phillip; Aube, Jeffrey; Xu, Liang; Lorenz, John N; Blaxall, Burns C; Rubinstein, Jack; Benoit, Joshua B; Tranter, Michael 2019. Human antigen R as a therapeutic target in pathological cardiac hypertrophy. JCI insight, 4 4, Robbins, Nathan; Hooker, Edmond A; Hart, Kim W; Kapur, Sangita; Blomkalns, Andra 2019. Computed tomographic quantification of periaortic adipose tissue volume as a correlate of cardiovascular disease. Cardiology journal, 26 6, 802-804Daly, Patrick; Kayse, Regina; Rudick, Steven; Robbins, Nathan; Scheler, Jennifer; Harris, David; O'Donnell, Robert; Dwivedi, Alok K; Gerson, Myron C 2018. Feasibility and safety of exercise stress testing using an anti-gravity treadmill with Tc-99m tetrofosmin single-photon emission computed tomography (SPECT) myocardial perfusion imaging: A pilot non-randomized controlled study. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 25 4, 1092-1097Jones, Shannon M; Mann, Adrien; Conrad, Kelsey; Saum, Keith; Hall, David E; McKinney, Lisa M; Robbins, Nathan; Thompson, Joel; Peairs, Abigail D; Camerer, Eric; Rayner, Katey J; Tranter, Michael; Mackman, Nigel; Owens, A Phillip 2018. PAR2 (Protease-Activated Receptor 2) Deficiency Attenuates Atherosclerosis in Mice. Arteriosclerosis, thrombosis, and vascular biology, 38 6, 1271-1282Koch, Sheryl E; Nieman, Michelle L; Robbins, Nathan; Slone, Samuel; Worley, Mariah; Green, Lisa C; Chen, Yamei; Barlow, Alexandria; Tranter, Michael; Wang, HongSheng; Lorenz, John N; Rubinstein, Jack 2018. Tranilast Blunts the Hypertrophic and Fibrotic Response to Increased Afterload Independent of Cardiomyocyte Transient Receptor Potential Vanilloid 2 Channels. Journal of cardiovascular pharmacology, 72 1, 40-48Liu, Guan-Sheng; Gardner, George; Adly, George; Jiang, Min; Cai, Wen-Feng; Lam, Chi Keung; Alogaili, Fawzi; Robbins, Nathan; Rubinstein, Jack; Kranias, Evangelia G 2018. A novel human S10F-Hsp20 mutation induces lethal peripartum cardiomyopathy. Journal of cellular and molecular medicine, 22 8, 3911-3919Owens, A Phillip; Robbins, Nathan; Saum, Keith; Jones, Shannon M; Kirschner, Akiva; Woo, Jessica G; McCoy, Connie; Slone, Samuel; Rothenberg, Marc E; Urbina, Elaine M; Tranter, Michael; Rubinstein, Jack 2018. Tefillin use induces remote ischemic preconditioning pathways in healthy men. American journal of physiology. Heart and circulatory physiology, 315 6, H1748-H1758Robbins, Nathan; Gilbert, Mark; Kumar, Mohit; McNamara, James W; Daly, Patrick; Koch, Sheryl E; Conway, Ginger; Effat, Mohamed; Woo, Jessica G; Sadayappan, Sakthivel; Rubinstein, Jack 2018. Probenecid Improves Cardiac Function in Patients With Heart Failure With Reduced Ejection Fraction In Vivo and Cardiomyocyte Calcium Sensitivity In Vitro. Journal of the American Heart Association, 7 2, Jones, Shannon; Mann, Adrien; Worley, Mariah C; Fulford, Logan; Hall, David; Karani, Rajiv; Jiang, Min; Robbins, Nathan; Rubinstein, Jack; Koch, Sheryl E 2017. The role of transient receptor potential vanilloid 2 channel in cardiac aging. Aging clinical and experimental research, 29 5, 863-873Koch, Sheryl E; Mann, Adrien; Jones, Shannon; Robbins, Nathan; Alkhattabi, Abdullah; Worley, Mariah C; Gao, Xu; Lasko-Roiniotis, Valerie M; Karani, Rajiv; Fulford, Logan; Jiang, Min; Nieman, Michelle; Lorenz, John N; Rubinstein, Jack 2017. Transient receptor potential vanilloid 2 function regulates cardiac hypertrophy via stretch-induced activation. Journal of hypertension, 35 3, 602-611Naticchioni, Mindi; Karani, Rajiv; Smith, Margaret A; Onusko, Evan; Robbins, Nathan; Jiang, Min; Radzyukevich, Tatiana; Fulford, Logan; Gao, Xu; Apel, Ryan; Heiny, Judith; Rubinstein, Jack; Koch, Sheryl E 2015. Transient Receptor Potential Vanilloid 2 Regulates Myocardial Response to Exercise. PloS one, 10 9, e0136901Mann, Adrien; Thompson, Allie; Robbins, Nathan; Blomkalns, Andra L 2014. Localization, identification, and excision of murine adipose depots. Journal of visualized experiments : JoVE, 94, Robbins, Nathan; Thompson, Allie; Mann, Adrien; Blomkalns, Andra L 2014. Isolation and excision of murine aorta; a versatile technique in the study of cardiovascular disease. Journal of visualized experiments : JoVE, 93, e52172Rubinstein, Jack; Lasko, Valerie M; Koch, Sheryl E; Singh, Vivek P; Carreira, Vinicius; Robbins, Nathan; Patel, Amit R; Jiang, Min; Bidwell, Philip; Kranias, Evangelia G; Jones, W Keith; Lorenz, John N 2014. Novel role of transient receptor potential vanilloid 2 in the regulation of cardiac performance. American journal of physiology. Heart and circulatory physiology, 306 4, H574-84Basford, Joshua E; Koch, Sheryl; Anjak, Ahmad; Singh, Vivek P; Krause, Eric G; Robbins, Nathan; Weintraub, Neal L; Hui, David Y; Rubinstein, Jack 2013. Smooth muscle LDL receptor-related protein-1 deletion induces aortic insufficiency and promotes vascular cardiomyopathy in mice. PloS one, 8 11, e82026Koch, Sheryl E; Haworth, Kevin J; Robbins, Nathan; Smith, Margaret A; Lather, Navneet; Anjak, Ahmad; Jiang, Min; Varma, Priyanka; Jones, W Keith; Rubinstein, Jack 2013. Age- and gender-related changes in ventricular performance in wild-type FVB/N mice as evaluated by conventional and vector velocity echocardiography imaging: a retrospective study. Ultrasound in medicine & biology, 39 11, 2034-43Koch, Sheryl E; Tranter, Michael; Robbins, Nathan; Luther, Kristin; Singh, Umesh; Jiang, Min; Ren, Xiaoping; Tee, Trisha; Smith, Leah; Varma, Priyanka; Jones, W Keith; Rubinstein, Jack 2013. Probenecid as a noninjurious positive inotrope in an ischemic heart disease murine model. Journal of cardiovascular pharmacology and therapeutics, 18 3, 280-9Lam CK, Zhao W, Cai W, Vafiadaki E, Florea SM, Ren X, Liu Y, Robbins N, Zhang Z, Zhou X, Jiang M, Rubinstein J, Jones WK, and Kranias EG 2013. Novel Role of HAX-1 in Ischemic Injury Protection: Involvement of Hsp90 Circulation Research, 112 1, 79Robbins, Nathan; Koch, Sheryl E; Rubinstein, Jack 2013. Targeting TRPV1 and TRPV2 for potential therapeutic interventions in cardiovascular disease. Translational research : the journal of laboratory and clinical medicine, 161 6, 469-76Koch, Sheryl E; Gao, Xiaoqian; Haar, Lauren; Jiang, Min; Lasko, Valerie M; Robbins, Nathan; Cai, Wenfeng; Brokamp, Cole; Varma, Priyanka; Tranter, Michael; Liu, Yong; Ren, Xiaoping; Lorenz, John N; Wang, Hong-Sheng; Jones, W Keith; Rubinstein, Jack 2012. Probenecid: novel use as a non-injurious positive inotrope acting via cardiac TRPV2 stimulation. Journal of molecular and cellular cardiology, 53 1, 134-44Robbins, Nathan; Koch, Sheryl E; Tranter, Michael; Rubinstein, Jack 2012. The history and future of probenecid. Cardiovascular toxicology, 12 1, 1-9
Rubinstein, Jack; Robbins, Nathan; Evans, Karen; Foster, Gabrielle; Mcconeghy, Kevin; Onadeko, Toluwalope; Bunke, Julie; Parent, Melanie; Luo, Xi; Joseph, Jacob; Wu, Wen-Chih 2022. Repurposing Probenecid for the Treatment of Heart Failure (Re-Prosper-HF): a study protocol for a randomized placebo-controlled clinical trial. Trials, 23 1, 266Kirschner, Akiva; Koch, Sheryl E; Robbins, Nathan; Karthik, Felix; Mudigonda, Parvathi; Ramasubramanian, Ranjani; Nieman, Michelle L; Lorenz, John N; Rubinstein, Jack 2021. Pharmacologic Inhibition of Pain Response to Incomplete Vascular Occlusion Blunts Cardiovascular Preconditioning Response. Cardiovascular toxicology, 21 11, 889-900Li, Yutian; Deng, Shan; Wang, Xiaohong; Huang, Wei; Chen, Jing; Robbins, Nathan; Mu, Xingjiang; Essandoh, Kobina; Peng, Tianqing; Jegga, Anil G; Rubinstein, Jack; Adams, David E; Wang, Yigang; Peng, Jiangtong; Fan, Guo-Chang 2021. Sectm1a deficiency aggravates inflammation-triggered cardiac dysfunction through disruption of LXRα signalling in macrophages. Cardiovascular research, 117 3, 890-902O'Connor, Brian; Robbins, Nathan; Koch, Sheryl E; Rubinstein, Jack 2021. TRPV2 channel-based therapies in the cardiovascular field. Molecular underpinnings of clinically relevant therapies. Progress in biophysics and molecular biology, 159 , 118-125Horimatsu, Tetsuo; Blomkalns, Andra L; Ogbi, Mourad; Moses, Mary; Kim, David; Patel, Sagar; Gilreath, Nicole; Reid, Lauren; Benson, Tyler W; Pye, Jonathan; Ahmadieh, Samah; Thompson, Allie; Robbins, Nathan; Mann, Adrien; Edgell, Ashlee; Benjamin, Stephanie; Stansfield, Brian K; Huo, Yuqing; Fulton, David J; Agarwal, Gautam; Singh, Nagendra; Offermanns, Stefan; Weintraub, Neal L; Kim, Ha Won 2020. Niacin protects against abdominal aortic aneurysm formation via GPR109A independent mechanisms: role of NAD+/nicotinamide. Cardiovascular research, 116 14, 2226-2238Onusko, Evan; McDermott, Michael R; Robbins, Nathan; Liu, Guansheng; Kranias, Evangelia G; Rubinstein, Jack; Koch, Sheryl E 2020. Probenecid treatment improves outcomes in a novel mouse model of peripartum cardiomyopathy. PloS one, 15 3, e0230386Gardner, George T; Travers, Joshua G; Qian, Jiang; Liu, Guan-Sheng; Haghighi, Kobra; Robbins, Nathan; Jiang, Min; Li, Yutian; Fan, Guo-Chang; Rubinstein, Jack; Blaxall, Burns C; Kranias, Evangelia G 2019. Phosphorylation of Hsp20 Promotes Fibrotic Remodeling and Heart Failure. JACC. Basic to translational science, 4 2, 188-199Green, Lisa C; Anthony, Sarah R; Slone, Samuel; Lanzillotta, Lindsey; Nieman, Michelle L; Wu, Xiaoqing; Robbins, Nathan; Jones, Shannon M; Roy, Sudeshna; Owens, A Phillip; Aube, Jeffrey; Xu, Liang; Lorenz, John N; Blaxall, Burns C; Rubinstein, Jack; Benoit, Joshua B; Tranter, Michael 2019. Human antigen R as a therapeutic target in pathological cardiac hypertrophy. JCI insight, 4 4, Robbins, Nathan; Hooker, Edmond A; Hart, Kim W; Kapur, Sangita; Blomkalns, Andra 2019. Computed tomographic quantification of periaortic adipose tissue volume as a correlate of cardiovascular disease. Cardiology journal, 26 6, 802-804Daly, Patrick; Kayse, Regina; Rudick, Steven; Robbins, Nathan; Scheler, Jennifer; Harris, David; O'Donnell, Robert; Dwivedi, Alok K; Gerson, Myron C 2018. Feasibility and safety of exercise stress testing using an anti-gravity treadmill with Tc-99m tetrofosmin single-photon emission computed tomography (SPECT) myocardial perfusion imaging: A pilot non-randomized controlled study. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 25 4, 1092-1097Jones, Shannon M; Mann, Adrien; Conrad, Kelsey; Saum, Keith; Hall, David E; McKinney, Lisa M; Robbins, Nathan; Thompson, Joel; Peairs, Abigail D; Camerer, Eric; Rayner, Katey J; Tranter, Michael; Mackman, Nigel; Owens, A Phillip 2018. PAR2 (Protease-Activated Receptor 2) Deficiency Attenuates Atherosclerosis in Mice. Arteriosclerosis, thrombosis, and vascular biology, 38 6, 1271-1282Koch, Sheryl E; Nieman, Michelle L; Robbins, Nathan; Slone, Samuel; Worley, Mariah; Green, Lisa C; Chen, Yamei; Barlow, Alexandria; Tranter, Michael; Wang, HongSheng; Lorenz, John N; Rubinstein, Jack 2018. Tranilast Blunts the Hypertrophic and Fibrotic Response to Increased Afterload Independent of Cardiomyocyte Transient Receptor Potential Vanilloid 2 Channels. Journal of cardiovascular pharmacology, 72 1, 40-48Liu, Guan-Sheng; Gardner, George; Adly, George; Jiang, Min; Cai, Wen-Feng; Lam, Chi Keung; Alogaili, Fawzi; Robbins, Nathan; Rubinstein, Jack; Kranias, Evangelia G 2018. A novel human S10F-Hsp20 mutation induces lethal peripartum cardiomyopathy. Journal of cellular and molecular medicine, 22 8, 3911-3919Owens, A Phillip; Robbins, Nathan; Saum, Keith; Jones, Shannon M; Kirschner, Akiva; Woo, Jessica G; McCoy, Connie; Slone, Samuel; Rothenberg, Marc E; Urbina, Elaine M; Tranter, Michael; Rubinstein, Jack 2018. Tefillin use induces remote ischemic preconditioning pathways in healthy men. American journal of physiology. Heart and circulatory physiology, 315 6, H1748-H1758Robbins, Nathan; Gilbert, Mark; Kumar, Mohit; McNamara, James W; Daly, Patrick; Koch, Sheryl E; Conway, Ginger; Effat, Mohamed; Woo, Jessica G; Sadayappan, Sakthivel; Rubinstein, Jack 2018. Probenecid Improves Cardiac Function in Patients With Heart Failure With Reduced Ejection Fraction In Vivo and Cardiomyocyte Calcium Sensitivity In Vitro. Journal of the American Heart Association, 7 2, Jones, Shannon; Mann, Adrien; Worley, Mariah C; Fulford, Logan; Hall, David; Karani, Rajiv; Jiang, Min; Robbins, Nathan; Rubinstein, Jack; Koch, Sheryl E 2017. The role of transient receptor potential vanilloid 2 channel in cardiac aging. Aging clinical and experimental research, 29 5, 863-873Koch, Sheryl E; Mann, Adrien; Jones, Shannon; Robbins, Nathan; Alkhattabi, Abdullah; Worley, Mariah C; Gao, Xu; Lasko-Roiniotis, Valerie M; Karani, Rajiv; Fulford, Logan; Jiang, Min; Nieman, Michelle; Lorenz, John N; Rubinstein, Jack 2017. Transient receptor potential vanilloid 2 function regulates cardiac hypertrophy via stretch-induced activation. Journal of hypertension, 35 3, 602-611Naticchioni, Mindi; Karani, Rajiv; Smith, Margaret A; Onusko, Evan; Robbins, Nathan; Jiang, Min; Radzyukevich, Tatiana; Fulford, Logan; Gao, Xu; Apel, Ryan; Heiny, Judith; Rubinstein, Jack; Koch, Sheryl E 2015. Transient Receptor Potential Vanilloid 2 Regulates Myocardial Response to Exercise. PloS one, 10 9, e0136901Mann, Adrien; Thompson, Allie; Robbins, Nathan; Blomkalns, Andra L 2014. Localization, identification, and excision of murine adipose depots. Journal of visualized experiments : JoVE, 94, Robbins, Nathan; Thompson, Allie; Mann, Adrien; Blomkalns, Andra L 2014. Isolation and excision of murine aorta; a versatile technique in the study of cardiovascular disease. Journal of visualized experiments : JoVE, 93, e52172Rubinstein, Jack; Lasko, Valerie M; Koch, Sheryl E; Singh, Vivek P; Carreira, Vinicius; Robbins, Nathan; Patel, Amit R; Jiang, Min; Bidwell, Philip; Kranias, Evangelia G; Jones, W Keith; Lorenz, John N 2014. Novel role of transient receptor potential vanilloid 2 in the regulation of cardiac performance. American journal of physiology. Heart and circulatory physiology, 306 4, H574-84Basford, Joshua E; Koch, Sheryl; Anjak, Ahmad; Singh, Vivek P; Krause, Eric G; Robbins, Nathan; Weintraub, Neal L; Hui, David Y; Rubinstein, Jack 2013. Smooth muscle LDL receptor-related protein-1 deletion induces aortic insufficiency and promotes vascular cardiomyopathy in mice. PloS one, 8 11, e82026Koch, Sheryl E; Haworth, Kevin J; Robbins, Nathan; Smith, Margaret A; Lather, Navneet; Anjak, Ahmad; Jiang, Min; Varma, Priyanka; Jones, W Keith; Rubinstein, Jack 2013. Age- and gender-related changes in ventricular performance in wild-type FVB/N mice as evaluated by conventional and vector velocity echocardiography imaging: a retrospective study. Ultrasound in medicine & biology, 39 11, 2034-43Koch, Sheryl E; Tranter, Michael; Robbins, Nathan; Luther, Kristin; Singh, Umesh; Jiang, Min; Ren, Xiaoping; Tee, Trisha; Smith, Leah; Varma, Priyanka; Jones, W Keith; Rubinstein, Jack 2013. Probenecid as a noninjurious positive inotrope in an ischemic heart disease murine model. Journal of cardiovascular pharmacology and therapeutics, 18 3, 280-9Lam CK, Zhao W, Cai W, Vafiadaki E, Florea SM, Ren X, Liu Y, Robbins N, Zhang Z, Zhou X, Jiang M, Rubinstein J, Jones WK, and Kranias EG 2013. Novel Role of HAX-1 in Ischemic Injury Protection: Involvement of Hsp90 Circulation Research, 112 1, 79Robbins, Nathan; Koch, Sheryl E; Rubinstein, Jack 2013. Targeting TRPV1 and TRPV2 for potential therapeutic interventions in cardiovascular disease. Translational research : the journal of laboratory and clinical medicine, 161 6, 469-76Koch, Sheryl E; Gao, Xiaoqian; Haar, Lauren; Jiang, Min; Lasko, Valerie M; Robbins, Nathan; Cai, Wenfeng; Brokamp, Cole; Varma, Priyanka; Tranter, Michael; Liu, Yong; Ren, Xiaoping; Lorenz, John N; Wang, Hong-Sheng; Jones, W Keith; Rubinstein, Jack 2012. Probenecid: novel use as a non-injurious positive inotrope acting via cardiac TRPV2 stimulation. Journal of molecular and cellular cardiology, 53 1, 134-44Robbins, Nathan; Koch, Sheryl E; Tranter, Michael; Rubinstein, Jack 2012. The history and future of probenecid. Cardiovascular toxicology, 12 1, 1-9