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Photo of Liang Niu

Liang Niu

Assistant Professor

  • Ph.D.: Ohio State University
  • Ph.D.: Ohio State University
  • M.S.: Peking University
  • B.S.: Hubei University
Research Interests

1) Statistical bioinformatics (methodology): RNA-Seq, ChIA-PET, methylation array and PacBio sequencing; 2) Statistical bioinformatics (consulting): data analysis for RNA-Seq, ChIA-PET, methylation array, and mass spectrometry; 3) Biostatistical consulting: study planning and design, power calculations, and statistical modeling and analysis; 4) Data mining of public domain omics datasets (such as TCGA datasets).

Contact Information
  • Kettering Laboratory Room 143
  • 160 Panzeca Way
  • Cincinnati, Ohio 45267
  • Office 513-558-7221
  • Email

Peer Reviewed Publications

Manju Sharma, Shuangmin Zhang, Liang Niu, David M Lewinsohn, Xiang Zhang and Shouxiong Huang 2020. Mucosal-Associated Invariant T Cells Develop an Innate-Like Transcriptomic Program in Anti-mycobacterial Responses Frontiers in Immunology, 11 , 1136

Zongli Xu, Changchun Xie, Jack Taylor and Liang Niu 2020. ipDMR: Identification of differentially methylated regions with interval P values Bioinformatics, btaa732 ,

Alexis D. Greene, Jessica A. Kendziorski, Jeanette M. Buckholz, Liang Niu, Changchun Xie, Susan M. Pinney, Katherine A. Burns 2019. Elevated serum chemokines are independently associated with both endometriosis and uranium exposure Reproductive Toxicology, 84 , 26-31

Chunmin Ge, Chrystelle L. Vilfranc, Lixiao Che, Raj K. Pandita, Shashank Hambarde, Paul R. Andreassen, Liang Niu, Olugbenga Olowokure, Shimul Shah, Susan E. Waltz, Lee Zou, Jiang Wang, Tej K. Pandita, Chunying Du 2019. The BRUCE‐ATR Signaling Axis Is Required for Accurate DNA Replication and Suppression of Liver Cancer Development Hepatology, , 10.1002/hep.30529

Scott M Langevin, Damaris Kuhnell, Liang Niu, Jacek Biesiada, Yuet-Kin Leung, Ranjan Deka, Aimin Chen, Mario Medvedovic, Karl T Kelsey, Susan Kasper and Xiang Zhang 2019. Comprehensive mapping of the methylation landscape of 16 CpG-dense regions in oral and pharyngeal squamous cell carcinoma Epigenomics, 11 9, 987-1002

Weichun Huang, Mario Medvedovic, Jingwen Zhang, Liang Niu 2019. ChIAPoP: a new tool for ChIA-PET data analysis Nucleic Acids Research, , gkz062

Xueheng Zhao, Liang Niu, Carlo Clerici, Roberta Russo, Melissa Byrd and Kenneth D.R. Setchell 2019. Data analysis of MS-based clinical lipidomics studies with crossover design: A tutorial mini-review of statistical methods Clinical Mass Spectrometry, 13 , 5-17

Sulsal‐Ul Haque, Liang Niu, Damaris Kuhnell, Jacob Hendershot, Jacek Biesiada, Wen Niu, Matthew C. Hagan, Karl T. Kelsey, Keith A. Casper, Trisha M. Wise‐Draper, Mario Medvedovic, Scott M. Langevin 2018. Differential expression and prognostic value of long non-coding RNA in HPV-negative head and neck squamous cell carcinoma Head & Neck, 40 , 1555–1564

Yuet-Kin Leung, Bin Ouyang, Liang Niu, Changchun Xie, Jun Ying, Mario Medvedovic, Aimin Chen, Pal Weihe, Damaskini Valvi, Philippe Grandjean, Shuk-Mei Ho 2018. Identification of sex-specific DNA methylation changes driven by specific chemicals in cord blood in a Faroese birth cohort Epigenetics, 13 3, 290-300

Hongqi Liu, Xizhi Feng, Kelli N. Ennis, Catherine A. Behrmann, Pranjal Sarma, Tony T. Jiang, Satoshi Kofuji, Liang Niu, Yiwen Stratton, Hala Elnakat Thomas, Sang-Oh Yoon, Atsuo T. Sasaki, David R. Plas 2017. Pharmacologic Targeting of S6K1 in PTEN-Deficient Neoplasia Cell reports, 18 9, 2088

Manju Sharma, Xiang Zhang, Shuangmin Zhang, Liang Niu, Shuk-mei Ho, Aimin Chen, Shouxiong Huang 2017. Inhibition of endocytic lipid antigen presentation by common lipophilic environmental pollutants Scientific Reports, 7 , 2085

Zongli Xu, Sabine A. S. Langie, Patrick De Boever, Jack A. Taylor and Liang Niu 2017. RELIC: a novel dye-bias correction method for Illumina Methylation BeadChip BMC Genomics, 18 4,

Liang Chen, Zhimin Peng, Qinghang Meng, Maureen Mongan, Jingcai Wang, Maureen Sartor, Jing Chen, Liang Niu, Mario Medvedovic, Winston Kao, Ying Xia 2016. Loss of IκB kinase β promotes myofibroblast transformation and senescence through activation of the ROS-TGFβ autocrine loop Protein & Cell, 7 5, 338–350

Liang Niu, Zongli Xu and Jack A. Taylor 2016. RCP: a novel probe design bias correction method for Illumina Methylation BeadChip Bioinformatics, 32 17, 2659-2663

Zongli Xu, Jack A. Taylor, Yuet-Kin Leung, Shuk-Mei Ho and Liang Niu 2016. oxBS-MLE: An efficient method to estimate 5-methylcytosine and 5-hydroxymethylcytosine in paired bisulfite and oxidative bisulfite treated DNA Bioinformatics, 32 23, 3667-3669

Zongli Xu, Liang Niu, Leping Li and Jack A. Taylor 2016. ENmix: a novel background correction method for Illumina HumanMethylation450 BeadChip Nucleic Acids Research, 44 3, e20

Jing Dong, Jingyun Yang, Greg Tranah, Nora Franceschini, Neeta Parimi, Gorka Alkorta-Aranburu, Zongli Xu, Alvaro Alonso, Steven R. Cummings, Myriam Fornage, Xuemei Huang, Stephen Kritchevsky, Yongmei Liu, Stephanie London, Liang Niu, Robert S. Wilson, Philip L. De Jager, Lei Yu, Andrew B. Singleton, Tamara Harris, Thomas H. Mosley Jr, Jayant M. Pinto, David A. Bennett and Honglei Chen 2015. Genome-wide Meta-analysis on the Sense of Smell Among US Older Adults Medicine, 94 47, e1892

Liang Niu and Shili Lin 2015. A Bayesian mixture model for chromatin interaction data Statistical Applications in Genetics and Molecular Biology, 14 1, 53-64

Liang Niu, Guoliang Li and Shili Lin 2014. Statistical models for detecting differential chromatin interactions mediated by a protein PLoS ONE, 9 5, e97560

Liang Niu, Weichun Huang, David M. Umbach and Leping Li 2014. IUTA: a tool for effectively detecting differential isoform usage from RNA-Seq data BMC Genomics, 15 862,

Yuanyuan Li, Weichun Huang, Liang Niu, David M. Umbach, Shay Covo and Leping Li 2013. Characterization of constitutive CTCF/cohesin loci: a possible role in establishing topological domains in mammalian genomes BMC Genomics, 14 553,

Cai Heng Li, Liang Niu, Akos Seress and Ronald Solomon 2010. The vertex primitive and vertex bi-primitive s-arc regular graphs Journal of Combinatorial Theory, Series B, 100 4, 359–366