Education/CredentialsPostdoc: University of Pennsylvania (Cancer Biology)Ph.D.: Washington University (Immunology)Bachelor's Degree: University of Notre Dame (Biological Sciences) Contact Information Email plasd@ucmail.uc.edu Research InterestsThe Plas lab aims to discover mechanisms that link cancer-causing mutations to oncogenic metabolism in cancers affected by mutations in PTEN and PI3K, including cancers of the blood, brain, and breast. Current work is investigating the metabolic and apoptotic effects of targeting the protein kinase S6K1, using both genetic approaches and emerging experimental therapeutics. Peer Reviewed Publications Garrett, Matthew C; Albano, Rebecca; Carnwath, Troy; Elahi, Lubayna; Behrmann, Catherine A; Pemberton, Merissa; Woo, Daniel; O'Brien, Eric; VanCauwenbergh, Brett; Perentesis, John; Shah, Sanjit; Hagan, Matthew; Kendler, Ady; Zhao, Chuntao; Paranjpe, Aditi; Roskin, Krishna; Kornblum, Harley; Plas, David R; Lu, Q Richard 2023. HDAC1 and HDAC6 are essential for driving growth in IDH1 mutant glioma. Scientific reports, 13 1, 12433Shin, Sejeong; Han, Min-Joon; Jedrychowski, Mark P; Zhang, Ziyang; Shokat, Kevan M; Plas, David R; Dephoure, Noah; Yoon, Sang-Oh 2023. mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching. Cell reports, 42 8, 112868Verma, Rita; Aggarwal, Parul; Bischoff, Megan E; Reigle, James; Secic, Dina; Wetzel, Collin; VandenHeuvel, Katherine; Biesiada, Jacek; Ehmer, Birgit; Landero Figueroa, Julio A; Plas, David R; Medvedovic, Mario; Meller, Jarek; Czyzyk-Krzeska, Maria F 2023. Microtubule-associated protein MAP1LC3C regulates lysosomal exocytosis and induces zinc reprogramming in renal cancer cells. The Journal of biological chemistry, 299 5, 104663Garrett, Matthew C; Albano, Rebecca; Carnwath, Troy; Shah, Sanjit; Woo, Daniel; Lamba, Michael; Plas, David R; Paranjpe, Aditi; Roskin, Krishna; Zhao, Chuntao; Lu, Richard 2022. Chromatin structure predicts survival in glioma patients. Scientific reports, 12 1, 8221Karve, Aniruddha S; Desai, Janki M; Dave, Nimita; Wise-Draper, Trisha M; Gudelsky, Gary A; Phoenix, Timothy N; DasGupta, Biplab; Sengupta, Soma; Plas, David R; Desai, Pankaj B 2022. Potentiation of temozolomide activity against glioblastoma cells by aromatase inhibitor letrozole. Cancer chemotherapy and pharmacology, 90 4, 345-356Bischoff, Megan E; Zang, Yuanwei; Chu, Johnson; Price, Adam D; Ehmer, Birgit; Talbot, Nicholas J; Newbold, Michael J; Paul, Anurag; Guan, Jun-Lin; Plas, David R; Meller, Jarek; Czyzyk-Krzeska, Maria F 2021. Selective MAP1LC3C (LC3C) autophagy requires noncanonical regulators and the C-terminal peptide. The Journal of cell biology, 220 7, Czyzyk-Krzeska, Maria F; Landero Figueroa, Julio A; Gulati, Shuchi; Cunningham, John T; Meller, Jarek; ShamsaeI, Behrouz; Vemuri, Bhargav; Plas, David R 2021. Molecular and Metabolic Subtypes in Sporadic and Inherited Clear Cell Renal Cell Carcinoma. Genes, 12 3, Czyzyk-Krzeska, Maria F; Meller, Jarek; Landero Figueroa, Julio A; Plas, David R; Cunningham, John T 2021. Metabolic subtypes of clear cell renal cell carcinoma defined by tobacco smoking. Molecular & cellular oncology, 8 2, 1859917Koehler, Abigail; Karve, Aniruddha; Desai, Pankaj; Arbiser, Jack; Plas, David R; Qi, Xiaoyang; Read, Renee D; Sasaki, Atsuo T; Gawali, Vaibhavkumar S; Toukam, Donatien K; Bhattacharya, Debanjan; Kallay, Laura; Pomeranz Krummel, Daniel A; Sengupta, Soma 2021. Reuse of Molecules for Glioblastoma Therapy. Pharmaceuticals (Basel, Switzerland), 14 2, Qing, Ying; Dong, Lei; Gao, Lei; Li, Chenying; Li, Yangchan; Han, Li; Prince, Emily; Tan, Brandon; Deng, Xiaolan; Wetzel, Collin; Shen, Chao; Gao, Min; Chen, Zhenhua; Li, Wei; Zhang, Bin; Braas, Daniel; Ten Hoeve, Johanna; Sanchez, Gerardo Javier; Chen, Huiying; Chan, Lai N; Chen, Chun-Wei; Ann, David; Jiang, Lei; Müschen, Markus; Marcucci, Guido; Plas, David R; Li, Zejuan; Su, Rui; Chen, Jianjun 2021. R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m6A/PFKP/LDHB axis. Molecular cell, 81 5, 922-939.e9Reigle, James; Secic, Dina; Biesiada, Jacek; Wetzel, Collin; Shamsaei, Behrouz; Chu, Johnson; Zang, Yuanwei; Zhang, Xiang; Talbot, Nicholas J; Bischoff, Megan E; Zhang, Yongzhen; Thakar, Charuhas V; Gaitonde, Krishnanath; Sidana, Abhinav; Bui, Hai; Cunningham, John T; Zhang, Qing; Schmidt, Laura S; Linehan, W Marston; Medvedovic, Mario; Plas, David R; Figueroa, Julio A Landero; Meller, Jarek; Czyzyk-Krzeska, Maria F 2021. Tobacco smoking induces metabolic reprogramming of renal cell carcinoma. The Journal of clinical investigation, 131 1, Wang, Chenran; Haas, Michael A; Yeo, Syn Kok; Paul, Ritama; Yang, Fuchun; Vallabhapurapu, Subrahmanya; Qi, Xiaoyang; Plas, David R; Guan, Jun-Lin 2021. Autophagy mediated lipid catabolism facilitates glioma progression to overcome bioenergetic crisis. British journal of cancer, , Ren, Yan; Sivaganesan, Siva; Clark, Nicholas A; Zhang, Lixia; Biesiada, Jacek; Niu, Wen; Plas, David R; Medvedovic, Mario 2020. Predicting mechanism of action of cellular perturbations with pathway activity signatures. Bioinformatics (Oxford, England), , Sarma, Pranjal; Plas, David R 2020. Choreography of methylation: KDM4C histone demethylation enables ALKBH5 m6A RNA demethylation to sustain AML stem cells. Blood science (Baltimore, Md.), 2 4, 144-145Sliz, Anna; Locker, Kathryn C S; Lampe, Kristin; Godarova, Alzbeta; Plas, David R; Janssen, Edith M; Jones, Helen; Herr, Andrew B; Hoebe, Kasper 2019. Gab3 is required for IL-2- and IL-15-induced NK cell expansion and limits trophoblast invasion during pregnancy. Science immunology, 4 38, Wang, Chenran; Haas, Michael A; Yang, Fuchun; Yeo, Syn; Okamoto, Takako; Chen, Song; Wen, Jian; Sarma, Pranjal; Plas, David R; Guan, Jun-Lin 2019. Autophagic lipid metabolism sustains mTORC1 activity in TSC-deficient neural stem cells. Nature metabolism, 1 11, 1127-1140Su, Rui; Dong, Lei; Li, Chenying; Nachtergaele, Sigrid; Wunderlich, Mark; Qing, Ying; Deng, Xiaolan; Wang, Yungui; Weng, Xiaocheng; Hu, Chao; Yu, Mengxia; Skibbe, Jennifer; Dai, Qing; Zou, Dongling; Wu, Tong; Yu, Kangkang; Weng, Hengyou; Huang, Huilin; Ferchen, Kyle; Qin, Xi; Zhang, Bin; Qi, Jun; Sasaki, Atsuo T; Plas, David R; Bradner, James E; Wei, Minjie; Marcucci, Guido; Jiang, Xi; Mulloy, James C; Jin, Jie; He, Chuan; Chen, Jianjun 2018. R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling. Cell, 172 1-2, 90-105.e23Berman, Adi Y; Manna, Subrata; Schwartz, Naomi S; Katz, Yardena E; Sun, Yang; Behrmann, Catherine A; Yu, Jane J; Plas, David R; Alayev, Anya; Holz, Marina K 2017. ERRα regulates the growth of triple-negative breast cancer cells via S6K1-dependent mechanism. Signal transduction and targeted therapy, 2 , Li, Chenggang; Liu, Xiaolei; Liu, Yang; Zhang, Erik; Medepalli, Kantha; Masuda, Kohei; Li, Na; Kopras, Elizabeth J; Kwiatkowski, David J; Borchers, Michael T; Wikenheiser-Brokamp, Kathryn A; Osterburg, Andrew; Mays, Maxwell; Sun, Yang; Plas, David R; Sun, Julia L; Franz, David N; Capal, Jamie K; Alayev, Anya; Holz, Marina K; Krueger, Darcy A; Siroky, Brian J; Yu, Jane J 2017. Tuberin Regulates Prostaglandin Receptor-mediated Viability, via Rheb, in mTORC1-hyperactive Cells. Molecular cancer research : MCR, , Liu, Hongqi; Feng, Xizhi; Ennis, Kelli N; Behrmann, Catherine A; Sarma, Pranjal; Jiang, Tony T; Kofuji, Satoshi; Niu, Liang; Stratton, Yiwen; Thomas, Hala Elnakat; Yoon, Sang-Oh; Sasaki, Atsuo T; Plas, David R 2017. Pharmacologic Targeting of S6K1 in PTEN-Deficient Neoplasia. Cell reports, 18 9, 2088-2095Orr-Asman, Melissa A; Chu, Zhengtao; Jiang, Min; Worley, Mariah; LaSance, Kathleen; Koch, Sheryl E; Carreira, Vinicius S; Dahche, Hanan M; Plas, David R; Komurov, Kakajan; Qi, Xiaoyang; Mercer, Carol A; Anthony, Lowell B; Rubinstein, Jack; Thomas, Hala E 2017. mTOR Kinase Inhibition Effectively Decreases Progression of a Subset of Neuroendocrine Tumors that Progress on Rapalog Therapy and Delays Cardiac Impairment. Molecular cancer therapeutics, 16 11, 2432-2441Yoon, Sang-Oh; Shin, Sejeong; Karreth, Florian A; Buel, Gwen R; Jedrychowski, Mark P; Plas, David R; Dedhar, Shoukat; Gygi, Steven P; Roux, Philippe P; Dephoure, Noah; Blenis, John 2017. Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition. Molecular cell, , Ghosh, Joydeep; Kobayashi, Michihiro; Ramdas, Baskar; Chatterjee, Anindya; Ma, Peilin; Mali, Raghuveer Singh; Carlesso, Nadia; Liu, Yan; Plas, David R; Chan, Rebecca J; Kapur, Reuben 2016. S6K1 regulates hematopoietic stem cell self-renewal and leukemia maintenance. The Journal of clinical investigation, 126 7, 2621-5Shin, Sejeong; Buel, Gwen R; Wolgamott, Laura; Plas, David R; Asara, John M; Blenis, John; Yoon, Sang-Oh 2015. ERK2 Mediates Metabolic Stress Response to Regulate Cell Fate. Molecular cell, 59 3, 382-98Vallabhapurapu, Subrahmanya D; Noothi, Sunil K; Pullum, Derek A; Lawrie, Charles H; Pallapati, Rachel; Potluri, Veena; Kuntzen, Christian; Khan, Sohaib; Plas, David R; Orlowski, Robert Z; Chesi, Marta; Kuehl, W Michael; Bergsagel, P Leif; Karin, Michael; Vallabhapurapu, Sivakumar 2015. Transcriptional repression by the HDAC4-RelB-p52 complex regulates multiple myeloma survival and growth. Nature communications, 6 , 8428Hall, Daniel P; Cost, Nicholas G; Hegde, Shailaja; Kellner, Emily; Mikhaylova, Olga; Stratton, Yiwen; Ehmer, Birgit; Abplanalp, William A; Pandey, Raghav; Biesiada, Jacek; Harteneck, Christian; Plas, David R; Meller, Jarek; Czyzyk-Krzeska, Maria F 2014. TRPM3 and miR-204 establish a regulatory circuit that controls oncogenic autophagy in clear cell renal cell carcinoma. Cancer cell, 26 5, 738-53Unruh, Dusten; Turner, Kevin; Srinivasan, Ramprasad; Kocatürk, Begüm; Qi, Xiaoyang; Chu, Zhengtao; Aronow, Bruce J; Plas, David R; Gallo, Catherine A; Kalthoff, Holger; Kirchhofer, Daniel; Ruf, Wolfram; Ahmad, Syed A; Lucas, Fred V; Versteeg, Henri H; Bogdanov, Vladimir Y 2014. Alternatively spliced tissue factor contributes to tumor spread and activation of coagulation in pancreatic ductal adenocarcinoma. International journal of cancer. Journal international du cancer, 134 1, 9-20Barger, JF; Gallo, CA; Tandon, P; Liu, H; Sullivan, A; Grimes, HL; Plas, DR 2013. S6K1 determines the metabolic requirements for BCR-ABL survival Oncogene, 32 4, 453-61Ma, Li; Tao, Yongzhen; Duran, Angeles; Llado, Victoria; Galvez, Anita; Barger, Jennifer F; Castilla, Elias A; Chen, Jing; Yajima, Tomoko; Porollo, Aleksey; Medvedovic, Mario; Brill, Laurence M; Plas, David R; Riedl, Stefan J; Leitges, Michael; Diaz-Meco, Maria T; Richardson, Adam D; Moscat, Jorge 2013. Control of nutrient stress-induced metabolic reprogramming by PKC? in tumorigenesis. Cell, 152 3, 599-611Raynor, Jana; Sholl, Allyson; Plas, David R; Bouillet, Philippe; Chougnet, Claire A; Hildeman, David A 2013. IL-15 Fosters Age-Driven Regulatory T Cell Accrual in the Face of Declining IL-2 Levels. Frontiers in immunology, 4 , 161Aksoylar H, Lampe K, Barnes M, Plas DR, Hoebe K 2012. Loss of immunological tolerance in Gimap5-deficient mice is associated with loss of Foxo transcription factor expression in CD4+ lymphocytes Journal of Immunology, 188 1, 146Aksoylar, H Ibrahim; Lampe, Kristin; Barnes, Michael J; Plas, David R; Hoebe, Kasper 2012. Loss of immunological tolerance in Gimap5-deficient mice is associated with loss of Foxo in CD4+ T cells. Journal of immunology (Baltimore, Md. : 1950), 188 1, 146-54Czyzyk-Krzeska, Maria F; Meller, Jarek; Plas, David R 2012. Not all autophagy is equal. Autophagy, 8 7, 1155-6Mikhaylova, Olga; Stratton, Yiwen; Hall, Daniel; Kellner, Emily; Ehmer, Birgit; Drew, Angela F; Gallo, Catherine A; Plas, David R; Biesiada, Jacek; Meller, Jarek; Czyzyk-Krzeska, Maria F 2012. VHL-regulated MiR-204 suppresses tumor growth through inhibition of LC3B-mediated autophagy in renal clear cell carcinoma. Cancer cell, 21 4, 532-46Barger JF, Gallo CA, Torni KA, Merk L, Seibel WL, Nelson S, Plas DR 2011. Identification of Akt-selective cytotoxic compounds that enhance cytotoxic responses to rapamycin Cancer Biology & Therapy, 10 12, 1256Chougnet CA, Tripathi P, Lages CS, Raynor J, Sholl A, Fink P, Plas DR, Hildeman DA 2011. A major role for Bim in regulatory T cell homeostasis Journal of Immunology, 186 1, 156Chougnet, Claire A; Tripathi, Pulak; Lages, Celine S; Raynor, Jana; Sholl, Allyson; Fink, Pamela; Plas, David R; Hildeman, David A 2011. A major role for Bim in regulatory T cell homeostasis. Journal of immunology (Baltimore, Md. : 1950), 186 1, 156-63Coloff JL, MacIntyre AN, Nichols AN, Liu T, Gallo CA, Plas DR, Rathmell JC 2011. Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition Cancer Research, 71 15, 5204Coloff, Jonathan L; Macintyre, Andrew N; Nichols, Amanda G; Liu, Tingyu; Gallo, Catherine A; Plas, David R; Rathmell, Jeffrey C 2011. Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition. Cancer research, 71 15, 5204-13Giridhar PV, Funk HM, Gallo CA, Porollo A, Mercer CA, Plas DR, Drew AF 2011. Interleukin-6 receptor enhances early colonization of the murine omentum by upregulation of a mannose family receptor, LY75, in ovarian tumor cells Clinical and Experimental Metastasis, 28 8, 887Giridhar, Premkumar Vummidi; Funk, Holly M; Gallo, Catherine A; Porollo, Aleksey; Mercer, Carol A; Plas, David R; Drew, Angela F 2011. Interleukin-6 receptor enhances early colonization of the murine omentum by upregulation of a mannose family receptor, LY75, in ovarian tumor cells. Clinical & experimental metastasis, 28 8, 887-97Sommermann T, O’Neill , Plas DR, and Cahir-McFarland E 2011. IKKβ and NFκB transcription govern AKT-induced GLUT1 plasma membrane trafficking in B-lymphocytes Cancer Research, 71 23, 7291Sommermann, Thomas G; O'Neill, Kathleen; Plas, David R; Cahir-McFarland, Ellen 2011. IKK? and NF-?B transcription govern lymphoma cell survival through AKT-induced plasma membrane trafficking of GLUT1. Cancer research, 71 23, 7291-300Tandon P, Gallo CA, Khatri S, Barger, JF, Yepiskoposyan H, Plas DR 2011. Requirement for S6K1 to mediate glycolysis and apoptosis resistance induced by Pten-deficiency Proceedings of the National Academy of Sciences (USA), 108 6, 2361Tandon, Preeti; Gallo, Catherine A; Khatri, Shikha; Barger, Jennifer F; Yepiskoposyan, Hasmik; Plas, David R 2011. Requirement for ribosomal protein S6 kinase 1 to mediate glycolysis and apoptosis resistance induced by Pten deficiency. Proceedings of the National Academy of Sciences of the United States of America, 108 6, 2361-5Zhang Y, Johansson E, Miller ML, Jänicke RU, Ferguson DJ, Plas D, Meller J, Anderson MW 2011. Identification of a Conserved Anti-apoptotic Protein that Modulates the Mitochondrial Apoptosis Pathway Plos One, 6 9, e25284Barger JF, Plas DR 2010. Balancing biosynthesis and bioenergetics: metabolic programs in oncogenesis Endocrine-related cancer, , Barger, Jennifer F; Gallo, Catherine A; Torni, Kyle A; Merk, Lisa; Seibel, William L; Nelson, Sandra; Plas, David R 2010. Identification of Akt-selective cytotoxic compounds that enhance cytotoxic responses to rapamycin. Cancer biology & therapy, 10 12, 1256-61Khatri S, Yepiskoposyan H, Gallo CA, Tandon P, Plas DR 2010. FOXO3a regulates glycolysis via transcriptional control of tumor suppressor TSC1 The Journal of biological chemistry, 285 21, 15960-5Khatri S, Plas DR 2009. Targeting bioenergetics to enhance cancer chemotherapy: mitochondria SLP into apoptosis Cancer biology & therapy, 8 17, 1659-61Plas DR, Thomas G 2009. Tubers and tumors: rapamycin therapy for benign and malignant tumors Current opinion in cell biology, 21 2, 230-6Jones, Russell G; Plas, David R; Kubek, Sara; Buzzai, Monica; Mu, James; Xu, Yang; Birnbaum, Morris J; Thompson, Craig B 2005. AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Molecular cell, 18 3, 283-93Plas, David R; Thompson, Craig B 2005. Akt-dependent transformation: there is more to growth than just surviving. Oncogene, 24 50, 7435-42Arsham, Andrew M; Plas, David R; Thompson, Craig B; Simon, M Celeste 2004. Akt and hypoxia-inducible factor-1 independently enhance tumor growth and angiogenesis. Cancer research, 64 10, 3500-7Bauer, Daniel E; Harris, Marian H; Plas, David R; Lum, Julian J; Hammerman, Peter S; Rathmell, Jeffrey C; Riley, James L; Thompson, Craig B 2004. Cytokine stimulation of aerobic glycolysis in hematopoietic cells exceeds proliferative demand. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 18 11, 1303-5Elstrom, Rebecca L; Bauer, Daniel E; Buzzai, Monica; Karnauskas, Robyn; Harris, Marian H; Plas, David R; Zhuang, Hongming; Cinalli, Ryan M; Alavi, Abass; Rudin, Charles M; Thompson, Craig B 2004. Akt stimulates aerobic glycolysis in cancer cells. Cancer research, 64 11, 3892-9Karnauskas, Robyn; Niu, Qun; Talapatra, Sunit; Plas, David R; Greene, Marianne E; Crispino, John D; Rudin, Charles M 2003. Bcl-x(L) and Akt cooperate to promote leukemogenesis in vivo. Oncogene, 22 5, 688-98Plas, David R; Thompson, Craig B 2003. Akt activation promotes degradation of tuberin and FOXO3a via the proteasome. The Journal of biological chemistry, 278 14, 12361-6Rathmell, Jeffrey C; Fox, Casey J; Plas, David R; Hammerman, Peter S; Cinalli, Ryan M; Thompson, Craig B 2003. Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. Molecular and cellular biology, 23 20, 7315-28Arsham, Andrew M; Plas, David R; Thompson, Craig B; Simon, M Celeste 2002. Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1 alpha nor sufficient for HIF-1-dependent target gene transcription. The Journal of biological chemistry, 277 17, 15162-70Frauwirth, Kenneth A; Riley, James L; Harris, Marian H; Parry, Richard V; Rathmell, Jeffrey C; Plas, David R; Elstrom, Rebecca L; June, Carl H; Thompson, Craig B 2002. The CD28 signaling pathway regulates glucose metabolism. Immunity, 16 6, 769-77Plas, David R; Rathmell, Jeffrey C; Thompson, Craig B 2002. Homeostatic control of lymphocyte survival: potential origins and implications. Nature immunology, 3 6, 515-21Plas, David R; Thompson, Craig B 2002. Cell metabolism in the regulation of programmed cell death. Trends in endocrinology and metabolism: TEM, 13 2, 75-8Plas, D R; Talapatra, S; Edinger, A L; Rathmell, J C; Thompson, C B 2001. Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology. The Journal of biological chemistry, 276 15, 12041-8Vander Heiden, M G; Plas, D R; Rathmell, J C; Fox, C J; Harris, M H; Thompson, C B 2001. Growth factors can influence cell growth and survival through effects on glucose metabolism. Molecular and cellular biology, 21 17, 5899-912Dustin, L B; Plas, D R; Wong, J; Hu, Y T; Soto, C; Chan, A C; Thomas, M L 1999. Expression of dominant-negative src-homology domain 2-containing protein tyrosine phosphatase-1 results in increased Syk tyrosine kinase activity and B cell activation. Journal of immunology (Baltimore, Md. : 1950), 162 5, 2717-24Plas, D R; Williams, C B; Kersh, G J; White, L S; White, J M; Paust, S; Ulyanova, T; Allen, P M; Thomas, M L 1999. Cutting edge: the tyrosine phosphatase SHP-1 regulates thymocyte positive selection. Journal of immunology (Baltimore, Md. : 1950), 162 10, 5680-4Wang, L L; Blasioli, J; Plas, D R; Thomas, M L; Yokoyama, W M 1999. Specificity of the SH2 domains of SHP-1 in the interaction with the immunoreceptor tyrosine-based inhibitory motif-bearing receptor gp49B. Journal of immunology (Baltimore, Md. : 1950), 162 3, 1318-23Plas, D R; Thomas, M L 1998. Negative regulation of antigen receptor signaling in lymphocytes. Journal of molecular medicine (Berlin, Germany), 76 8, 589-95Matsumoto, M; Lo, S F; Carruthers, C J; Min, J; Mariathasan, S; Huang, G; Plas, D R; Martin, S M; Geha, R S; Nahm, M H; Chaplin, D D 1996. Affinity maturation without germinal centres in lymphotoxin-alpha-deficient mice. Nature, 382 6590, 462-6Plas, D R; Johnson, R; Pingel, J T; Matthews, R J; Dalton, M; Roy, G; Chan, A C; Thomas, M L 1996. Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling. Science (New York, N.Y.), 272 5265, 1173-6Moe, A J; Plas, D R; Powell, K A; Smith, C H . Riboflavin uptake in microvillous and basal membrane vesicles isolated from full-term human placentas. Placenta, 15 2, 137-46
Research InterestsThe Plas lab aims to discover mechanisms that link cancer-causing mutations to oncogenic metabolism in cancers affected by mutations in PTEN and PI3K, including cancers of the blood, brain, and breast. Current work is investigating the metabolic and apoptotic effects of targeting the protein kinase S6K1, using both genetic approaches and emerging experimental therapeutics.
Peer Reviewed Publications Garrett, Matthew C; Albano, Rebecca; Carnwath, Troy; Elahi, Lubayna; Behrmann, Catherine A; Pemberton, Merissa; Woo, Daniel; O'Brien, Eric; VanCauwenbergh, Brett; Perentesis, John; Shah, Sanjit; Hagan, Matthew; Kendler, Ady; Zhao, Chuntao; Paranjpe, Aditi; Roskin, Krishna; Kornblum, Harley; Plas, David R; Lu, Q Richard 2023. HDAC1 and HDAC6 are essential for driving growth in IDH1 mutant glioma. Scientific reports, 13 1, 12433Shin, Sejeong; Han, Min-Joon; Jedrychowski, Mark P; Zhang, Ziyang; Shokat, Kevan M; Plas, David R; Dephoure, Noah; Yoon, Sang-Oh 2023. mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching. Cell reports, 42 8, 112868Verma, Rita; Aggarwal, Parul; Bischoff, Megan E; Reigle, James; Secic, Dina; Wetzel, Collin; VandenHeuvel, Katherine; Biesiada, Jacek; Ehmer, Birgit; Landero Figueroa, Julio A; Plas, David R; Medvedovic, Mario; Meller, Jarek; Czyzyk-Krzeska, Maria F 2023. Microtubule-associated protein MAP1LC3C regulates lysosomal exocytosis and induces zinc reprogramming in renal cancer cells. The Journal of biological chemistry, 299 5, 104663Garrett, Matthew C; Albano, Rebecca; Carnwath, Troy; Shah, Sanjit; Woo, Daniel; Lamba, Michael; Plas, David R; Paranjpe, Aditi; Roskin, Krishna; Zhao, Chuntao; Lu, Richard 2022. Chromatin structure predicts survival in glioma patients. Scientific reports, 12 1, 8221Karve, Aniruddha S; Desai, Janki M; Dave, Nimita; Wise-Draper, Trisha M; Gudelsky, Gary A; Phoenix, Timothy N; DasGupta, Biplab; Sengupta, Soma; Plas, David R; Desai, Pankaj B 2022. Potentiation of temozolomide activity against glioblastoma cells by aromatase inhibitor letrozole. Cancer chemotherapy and pharmacology, 90 4, 345-356Bischoff, Megan E; Zang, Yuanwei; Chu, Johnson; Price, Adam D; Ehmer, Birgit; Talbot, Nicholas J; Newbold, Michael J; Paul, Anurag; Guan, Jun-Lin; Plas, David R; Meller, Jarek; Czyzyk-Krzeska, Maria F 2021. Selective MAP1LC3C (LC3C) autophagy requires noncanonical regulators and the C-terminal peptide. The Journal of cell biology, 220 7, Czyzyk-Krzeska, Maria F; Landero Figueroa, Julio A; Gulati, Shuchi; Cunningham, John T; Meller, Jarek; ShamsaeI, Behrouz; Vemuri, Bhargav; Plas, David R 2021. Molecular and Metabolic Subtypes in Sporadic and Inherited Clear Cell Renal Cell Carcinoma. Genes, 12 3, Czyzyk-Krzeska, Maria F; Meller, Jarek; Landero Figueroa, Julio A; Plas, David R; Cunningham, John T 2021. Metabolic subtypes of clear cell renal cell carcinoma defined by tobacco smoking. Molecular & cellular oncology, 8 2, 1859917Koehler, Abigail; Karve, Aniruddha; Desai, Pankaj; Arbiser, Jack; Plas, David R; Qi, Xiaoyang; Read, Renee D; Sasaki, Atsuo T; Gawali, Vaibhavkumar S; Toukam, Donatien K; Bhattacharya, Debanjan; Kallay, Laura; Pomeranz Krummel, Daniel A; Sengupta, Soma 2021. Reuse of Molecules for Glioblastoma Therapy. Pharmaceuticals (Basel, Switzerland), 14 2, Qing, Ying; Dong, Lei; Gao, Lei; Li, Chenying; Li, Yangchan; Han, Li; Prince, Emily; Tan, Brandon; Deng, Xiaolan; Wetzel, Collin; Shen, Chao; Gao, Min; Chen, Zhenhua; Li, Wei; Zhang, Bin; Braas, Daniel; Ten Hoeve, Johanna; Sanchez, Gerardo Javier; Chen, Huiying; Chan, Lai N; Chen, Chun-Wei; Ann, David; Jiang, Lei; Müschen, Markus; Marcucci, Guido; Plas, David R; Li, Zejuan; Su, Rui; Chen, Jianjun 2021. R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m6A/PFKP/LDHB axis. Molecular cell, 81 5, 922-939.e9Reigle, James; Secic, Dina; Biesiada, Jacek; Wetzel, Collin; Shamsaei, Behrouz; Chu, Johnson; Zang, Yuanwei; Zhang, Xiang; Talbot, Nicholas J; Bischoff, Megan E; Zhang, Yongzhen; Thakar, Charuhas V; Gaitonde, Krishnanath; Sidana, Abhinav; Bui, Hai; Cunningham, John T; Zhang, Qing; Schmidt, Laura S; Linehan, W Marston; Medvedovic, Mario; Plas, David R; Figueroa, Julio A Landero; Meller, Jarek; Czyzyk-Krzeska, Maria F 2021. Tobacco smoking induces metabolic reprogramming of renal cell carcinoma. The Journal of clinical investigation, 131 1, Wang, Chenran; Haas, Michael A; Yeo, Syn Kok; Paul, Ritama; Yang, Fuchun; Vallabhapurapu, Subrahmanya; Qi, Xiaoyang; Plas, David R; Guan, Jun-Lin 2021. Autophagy mediated lipid catabolism facilitates glioma progression to overcome bioenergetic crisis. British journal of cancer, , Ren, Yan; Sivaganesan, Siva; Clark, Nicholas A; Zhang, Lixia; Biesiada, Jacek; Niu, Wen; Plas, David R; Medvedovic, Mario 2020. Predicting mechanism of action of cellular perturbations with pathway activity signatures. Bioinformatics (Oxford, England), , Sarma, Pranjal; Plas, David R 2020. Choreography of methylation: KDM4C histone demethylation enables ALKBH5 m6A RNA demethylation to sustain AML stem cells. Blood science (Baltimore, Md.), 2 4, 144-145Sliz, Anna; Locker, Kathryn C S; Lampe, Kristin; Godarova, Alzbeta; Plas, David R; Janssen, Edith M; Jones, Helen; Herr, Andrew B; Hoebe, Kasper 2019. Gab3 is required for IL-2- and IL-15-induced NK cell expansion and limits trophoblast invasion during pregnancy. Science immunology, 4 38, Wang, Chenran; Haas, Michael A; Yang, Fuchun; Yeo, Syn; Okamoto, Takako; Chen, Song; Wen, Jian; Sarma, Pranjal; Plas, David R; Guan, Jun-Lin 2019. Autophagic lipid metabolism sustains mTORC1 activity in TSC-deficient neural stem cells. Nature metabolism, 1 11, 1127-1140Su, Rui; Dong, Lei; Li, Chenying; Nachtergaele, Sigrid; Wunderlich, Mark; Qing, Ying; Deng, Xiaolan; Wang, Yungui; Weng, Xiaocheng; Hu, Chao; Yu, Mengxia; Skibbe, Jennifer; Dai, Qing; Zou, Dongling; Wu, Tong; Yu, Kangkang; Weng, Hengyou; Huang, Huilin; Ferchen, Kyle; Qin, Xi; Zhang, Bin; Qi, Jun; Sasaki, Atsuo T; Plas, David R; Bradner, James E; Wei, Minjie; Marcucci, Guido; Jiang, Xi; Mulloy, James C; Jin, Jie; He, Chuan; Chen, Jianjun 2018. R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling. Cell, 172 1-2, 90-105.e23Berman, Adi Y; Manna, Subrata; Schwartz, Naomi S; Katz, Yardena E; Sun, Yang; Behrmann, Catherine A; Yu, Jane J; Plas, David R; Alayev, Anya; Holz, Marina K 2017. ERRα regulates the growth of triple-negative breast cancer cells via S6K1-dependent mechanism. Signal transduction and targeted therapy, 2 , Li, Chenggang; Liu, Xiaolei; Liu, Yang; Zhang, Erik; Medepalli, Kantha; Masuda, Kohei; Li, Na; Kopras, Elizabeth J; Kwiatkowski, David J; Borchers, Michael T; Wikenheiser-Brokamp, Kathryn A; Osterburg, Andrew; Mays, Maxwell; Sun, Yang; Plas, David R; Sun, Julia L; Franz, David N; Capal, Jamie K; Alayev, Anya; Holz, Marina K; Krueger, Darcy A; Siroky, Brian J; Yu, Jane J 2017. Tuberin Regulates Prostaglandin Receptor-mediated Viability, via Rheb, in mTORC1-hyperactive Cells. Molecular cancer research : MCR, , Liu, Hongqi; Feng, Xizhi; Ennis, Kelli N; Behrmann, Catherine A; Sarma, Pranjal; Jiang, Tony T; Kofuji, Satoshi; Niu, Liang; Stratton, Yiwen; Thomas, Hala Elnakat; Yoon, Sang-Oh; Sasaki, Atsuo T; Plas, David R 2017. Pharmacologic Targeting of S6K1 in PTEN-Deficient Neoplasia. Cell reports, 18 9, 2088-2095Orr-Asman, Melissa A; Chu, Zhengtao; Jiang, Min; Worley, Mariah; LaSance, Kathleen; Koch, Sheryl E; Carreira, Vinicius S; Dahche, Hanan M; Plas, David R; Komurov, Kakajan; Qi, Xiaoyang; Mercer, Carol A; Anthony, Lowell B; Rubinstein, Jack; Thomas, Hala E 2017. mTOR Kinase Inhibition Effectively Decreases Progression of a Subset of Neuroendocrine Tumors that Progress on Rapalog Therapy and Delays Cardiac Impairment. Molecular cancer therapeutics, 16 11, 2432-2441Yoon, Sang-Oh; Shin, Sejeong; Karreth, Florian A; Buel, Gwen R; Jedrychowski, Mark P; Plas, David R; Dedhar, Shoukat; Gygi, Steven P; Roux, Philippe P; Dephoure, Noah; Blenis, John 2017. Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition. Molecular cell, , Ghosh, Joydeep; Kobayashi, Michihiro; Ramdas, Baskar; Chatterjee, Anindya; Ma, Peilin; Mali, Raghuveer Singh; Carlesso, Nadia; Liu, Yan; Plas, David R; Chan, Rebecca J; Kapur, Reuben 2016. S6K1 regulates hematopoietic stem cell self-renewal and leukemia maintenance. The Journal of clinical investigation, 126 7, 2621-5Shin, Sejeong; Buel, Gwen R; Wolgamott, Laura; Plas, David R; Asara, John M; Blenis, John; Yoon, Sang-Oh 2015. ERK2 Mediates Metabolic Stress Response to Regulate Cell Fate. Molecular cell, 59 3, 382-98Vallabhapurapu, Subrahmanya D; Noothi, Sunil K; Pullum, Derek A; Lawrie, Charles H; Pallapati, Rachel; Potluri, Veena; Kuntzen, Christian; Khan, Sohaib; Plas, David R; Orlowski, Robert Z; Chesi, Marta; Kuehl, W Michael; Bergsagel, P Leif; Karin, Michael; Vallabhapurapu, Sivakumar 2015. Transcriptional repression by the HDAC4-RelB-p52 complex regulates multiple myeloma survival and growth. Nature communications, 6 , 8428Hall, Daniel P; Cost, Nicholas G; Hegde, Shailaja; Kellner, Emily; Mikhaylova, Olga; Stratton, Yiwen; Ehmer, Birgit; Abplanalp, William A; Pandey, Raghav; Biesiada, Jacek; Harteneck, Christian; Plas, David R; Meller, Jarek; Czyzyk-Krzeska, Maria F 2014. TRPM3 and miR-204 establish a regulatory circuit that controls oncogenic autophagy in clear cell renal cell carcinoma. Cancer cell, 26 5, 738-53Unruh, Dusten; Turner, Kevin; Srinivasan, Ramprasad; Kocatürk, Begüm; Qi, Xiaoyang; Chu, Zhengtao; Aronow, Bruce J; Plas, David R; Gallo, Catherine A; Kalthoff, Holger; Kirchhofer, Daniel; Ruf, Wolfram; Ahmad, Syed A; Lucas, Fred V; Versteeg, Henri H; Bogdanov, Vladimir Y 2014. Alternatively spliced tissue factor contributes to tumor spread and activation of coagulation in pancreatic ductal adenocarcinoma. International journal of cancer. Journal international du cancer, 134 1, 9-20Barger, JF; Gallo, CA; Tandon, P; Liu, H; Sullivan, A; Grimes, HL; Plas, DR 2013. S6K1 determines the metabolic requirements for BCR-ABL survival Oncogene, 32 4, 453-61Ma, Li; Tao, Yongzhen; Duran, Angeles; Llado, Victoria; Galvez, Anita; Barger, Jennifer F; Castilla, Elias A; Chen, Jing; Yajima, Tomoko; Porollo, Aleksey; Medvedovic, Mario; Brill, Laurence M; Plas, David R; Riedl, Stefan J; Leitges, Michael; Diaz-Meco, Maria T; Richardson, Adam D; Moscat, Jorge 2013. Control of nutrient stress-induced metabolic reprogramming by PKC? in tumorigenesis. Cell, 152 3, 599-611Raynor, Jana; Sholl, Allyson; Plas, David R; Bouillet, Philippe; Chougnet, Claire A; Hildeman, David A 2013. IL-15 Fosters Age-Driven Regulatory T Cell Accrual in the Face of Declining IL-2 Levels. Frontiers in immunology, 4 , 161Aksoylar H, Lampe K, Barnes M, Plas DR, Hoebe K 2012. Loss of immunological tolerance in Gimap5-deficient mice is associated with loss of Foxo transcription factor expression in CD4+ lymphocytes Journal of Immunology, 188 1, 146Aksoylar, H Ibrahim; Lampe, Kristin; Barnes, Michael J; Plas, David R; Hoebe, Kasper 2012. Loss of immunological tolerance in Gimap5-deficient mice is associated with loss of Foxo in CD4+ T cells. Journal of immunology (Baltimore, Md. : 1950), 188 1, 146-54Czyzyk-Krzeska, Maria F; Meller, Jarek; Plas, David R 2012. Not all autophagy is equal. Autophagy, 8 7, 1155-6Mikhaylova, Olga; Stratton, Yiwen; Hall, Daniel; Kellner, Emily; Ehmer, Birgit; Drew, Angela F; Gallo, Catherine A; Plas, David R; Biesiada, Jacek; Meller, Jarek; Czyzyk-Krzeska, Maria F 2012. VHL-regulated MiR-204 suppresses tumor growth through inhibition of LC3B-mediated autophagy in renal clear cell carcinoma. Cancer cell, 21 4, 532-46Barger JF, Gallo CA, Torni KA, Merk L, Seibel WL, Nelson S, Plas DR 2011. Identification of Akt-selective cytotoxic compounds that enhance cytotoxic responses to rapamycin Cancer Biology & Therapy, 10 12, 1256Chougnet CA, Tripathi P, Lages CS, Raynor J, Sholl A, Fink P, Plas DR, Hildeman DA 2011. A major role for Bim in regulatory T cell homeostasis Journal of Immunology, 186 1, 156Chougnet, Claire A; Tripathi, Pulak; Lages, Celine S; Raynor, Jana; Sholl, Allyson; Fink, Pamela; Plas, David R; Hildeman, David A 2011. A major role for Bim in regulatory T cell homeostasis. Journal of immunology (Baltimore, Md. : 1950), 186 1, 156-63Coloff JL, MacIntyre AN, Nichols AN, Liu T, Gallo CA, Plas DR, Rathmell JC 2011. Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition Cancer Research, 71 15, 5204Coloff, Jonathan L; Macintyre, Andrew N; Nichols, Amanda G; Liu, Tingyu; Gallo, Catherine A; Plas, David R; Rathmell, Jeffrey C 2011. Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition. Cancer research, 71 15, 5204-13Giridhar PV, Funk HM, Gallo CA, Porollo A, Mercer CA, Plas DR, Drew AF 2011. Interleukin-6 receptor enhances early colonization of the murine omentum by upregulation of a mannose family receptor, LY75, in ovarian tumor cells Clinical and Experimental Metastasis, 28 8, 887Giridhar, Premkumar Vummidi; Funk, Holly M; Gallo, Catherine A; Porollo, Aleksey; Mercer, Carol A; Plas, David R; Drew, Angela F 2011. Interleukin-6 receptor enhances early colonization of the murine omentum by upregulation of a mannose family receptor, LY75, in ovarian tumor cells. Clinical & experimental metastasis, 28 8, 887-97Sommermann T, O’Neill , Plas DR, and Cahir-McFarland E 2011. IKKβ and NFκB transcription govern AKT-induced GLUT1 plasma membrane trafficking in B-lymphocytes Cancer Research, 71 23, 7291Sommermann, Thomas G; O'Neill, Kathleen; Plas, David R; Cahir-McFarland, Ellen 2011. IKK? and NF-?B transcription govern lymphoma cell survival through AKT-induced plasma membrane trafficking of GLUT1. Cancer research, 71 23, 7291-300Tandon P, Gallo CA, Khatri S, Barger, JF, Yepiskoposyan H, Plas DR 2011. Requirement for S6K1 to mediate glycolysis and apoptosis resistance induced by Pten-deficiency Proceedings of the National Academy of Sciences (USA), 108 6, 2361Tandon, Preeti; Gallo, Catherine A; Khatri, Shikha; Barger, Jennifer F; Yepiskoposyan, Hasmik; Plas, David R 2011. Requirement for ribosomal protein S6 kinase 1 to mediate glycolysis and apoptosis resistance induced by Pten deficiency. Proceedings of the National Academy of Sciences of the United States of America, 108 6, 2361-5Zhang Y, Johansson E, Miller ML, Jänicke RU, Ferguson DJ, Plas D, Meller J, Anderson MW 2011. Identification of a Conserved Anti-apoptotic Protein that Modulates the Mitochondrial Apoptosis Pathway Plos One, 6 9, e25284Barger JF, Plas DR 2010. Balancing biosynthesis and bioenergetics: metabolic programs in oncogenesis Endocrine-related cancer, , Barger, Jennifer F; Gallo, Catherine A; Torni, Kyle A; Merk, Lisa; Seibel, William L; Nelson, Sandra; Plas, David R 2010. Identification of Akt-selective cytotoxic compounds that enhance cytotoxic responses to rapamycin. Cancer biology & therapy, 10 12, 1256-61Khatri S, Yepiskoposyan H, Gallo CA, Tandon P, Plas DR 2010. FOXO3a regulates glycolysis via transcriptional control of tumor suppressor TSC1 The Journal of biological chemistry, 285 21, 15960-5Khatri S, Plas DR 2009. Targeting bioenergetics to enhance cancer chemotherapy: mitochondria SLP into apoptosis Cancer biology & therapy, 8 17, 1659-61Plas DR, Thomas G 2009. Tubers and tumors: rapamycin therapy for benign and malignant tumors Current opinion in cell biology, 21 2, 230-6Jones, Russell G; Plas, David R; Kubek, Sara; Buzzai, Monica; Mu, James; Xu, Yang; Birnbaum, Morris J; Thompson, Craig B 2005. AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Molecular cell, 18 3, 283-93Plas, David R; Thompson, Craig B 2005. Akt-dependent transformation: there is more to growth than just surviving. Oncogene, 24 50, 7435-42Arsham, Andrew M; Plas, David R; Thompson, Craig B; Simon, M Celeste 2004. Akt and hypoxia-inducible factor-1 independently enhance tumor growth and angiogenesis. Cancer research, 64 10, 3500-7Bauer, Daniel E; Harris, Marian H; Plas, David R; Lum, Julian J; Hammerman, Peter S; Rathmell, Jeffrey C; Riley, James L; Thompson, Craig B 2004. Cytokine stimulation of aerobic glycolysis in hematopoietic cells exceeds proliferative demand. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 18 11, 1303-5Elstrom, Rebecca L; Bauer, Daniel E; Buzzai, Monica; Karnauskas, Robyn; Harris, Marian H; Plas, David R; Zhuang, Hongming; Cinalli, Ryan M; Alavi, Abass; Rudin, Charles M; Thompson, Craig B 2004. Akt stimulates aerobic glycolysis in cancer cells. Cancer research, 64 11, 3892-9Karnauskas, Robyn; Niu, Qun; Talapatra, Sunit; Plas, David R; Greene, Marianne E; Crispino, John D; Rudin, Charles M 2003. Bcl-x(L) and Akt cooperate to promote leukemogenesis in vivo. Oncogene, 22 5, 688-98Plas, David R; Thompson, Craig B 2003. Akt activation promotes degradation of tuberin and FOXO3a via the proteasome. The Journal of biological chemistry, 278 14, 12361-6Rathmell, Jeffrey C; Fox, Casey J; Plas, David R; Hammerman, Peter S; Cinalli, Ryan M; Thompson, Craig B 2003. Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. Molecular and cellular biology, 23 20, 7315-28Arsham, Andrew M; Plas, David R; Thompson, Craig B; Simon, M Celeste 2002. Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1 alpha nor sufficient for HIF-1-dependent target gene transcription. The Journal of biological chemistry, 277 17, 15162-70Frauwirth, Kenneth A; Riley, James L; Harris, Marian H; Parry, Richard V; Rathmell, Jeffrey C; Plas, David R; Elstrom, Rebecca L; June, Carl H; Thompson, Craig B 2002. The CD28 signaling pathway regulates glucose metabolism. Immunity, 16 6, 769-77Plas, David R; Rathmell, Jeffrey C; Thompson, Craig B 2002. Homeostatic control of lymphocyte survival: potential origins and implications. Nature immunology, 3 6, 515-21Plas, David R; Thompson, Craig B 2002. Cell metabolism in the regulation of programmed cell death. Trends in endocrinology and metabolism: TEM, 13 2, 75-8Plas, D R; Talapatra, S; Edinger, A L; Rathmell, J C; Thompson, C B 2001. Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology. The Journal of biological chemistry, 276 15, 12041-8Vander Heiden, M G; Plas, D R; Rathmell, J C; Fox, C J; Harris, M H; Thompson, C B 2001. Growth factors can influence cell growth and survival through effects on glucose metabolism. Molecular and cellular biology, 21 17, 5899-912Dustin, L B; Plas, D R; Wong, J; Hu, Y T; Soto, C; Chan, A C; Thomas, M L 1999. Expression of dominant-negative src-homology domain 2-containing protein tyrosine phosphatase-1 results in increased Syk tyrosine kinase activity and B cell activation. Journal of immunology (Baltimore, Md. : 1950), 162 5, 2717-24Plas, D R; Williams, C B; Kersh, G J; White, L S; White, J M; Paust, S; Ulyanova, T; Allen, P M; Thomas, M L 1999. Cutting edge: the tyrosine phosphatase SHP-1 regulates thymocyte positive selection. Journal of immunology (Baltimore, Md. : 1950), 162 10, 5680-4Wang, L L; Blasioli, J; Plas, D R; Thomas, M L; Yokoyama, W M 1999. Specificity of the SH2 domains of SHP-1 in the interaction with the immunoreceptor tyrosine-based inhibitory motif-bearing receptor gp49B. Journal of immunology (Baltimore, Md. : 1950), 162 3, 1318-23Plas, D R; Thomas, M L 1998. Negative regulation of antigen receptor signaling in lymphocytes. Journal of molecular medicine (Berlin, Germany), 76 8, 589-95Matsumoto, M; Lo, S F; Carruthers, C J; Min, J; Mariathasan, S; Huang, G; Plas, D R; Martin, S M; Geha, R S; Nahm, M H; Chaplin, D D 1996. Affinity maturation without germinal centres in lymphotoxin-alpha-deficient mice. Nature, 382 6590, 462-6Plas, D R; Johnson, R; Pingel, J T; Matthews, R J; Dalton, M; Roy, G; Chan, A C; Thomas, M L 1996. Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling. Science (New York, N.Y.), 272 5265, 1173-6Moe, A J; Plas, D R; Powell, K A; Smith, C H . Riboflavin uptake in microvillous and basal membrane vesicles isolated from full-term human placentas. Placenta, 15 2, 137-46
Garrett, Matthew C; Albano, Rebecca; Carnwath, Troy; Elahi, Lubayna; Behrmann, Catherine A; Pemberton, Merissa; Woo, Daniel; O'Brien, Eric; VanCauwenbergh, Brett; Perentesis, John; Shah, Sanjit; Hagan, Matthew; Kendler, Ady; Zhao, Chuntao; Paranjpe, Aditi; Roskin, Krishna; Kornblum, Harley; Plas, David R; Lu, Q Richard 2023. HDAC1 and HDAC6 are essential for driving growth in IDH1 mutant glioma. Scientific reports, 13 1, 12433Shin, Sejeong; Han, Min-Joon; Jedrychowski, Mark P; Zhang, Ziyang; Shokat, Kevan M; Plas, David R; Dephoure, Noah; Yoon, Sang-Oh 2023. mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching. Cell reports, 42 8, 112868Verma, Rita; Aggarwal, Parul; Bischoff, Megan E; Reigle, James; Secic, Dina; Wetzel, Collin; VandenHeuvel, Katherine; Biesiada, Jacek; Ehmer, Birgit; Landero Figueroa, Julio A; Plas, David R; Medvedovic, Mario; Meller, Jarek; Czyzyk-Krzeska, Maria F 2023. Microtubule-associated protein MAP1LC3C regulates lysosomal exocytosis and induces zinc reprogramming in renal cancer cells. The Journal of biological chemistry, 299 5, 104663Garrett, Matthew C; Albano, Rebecca; Carnwath, Troy; Shah, Sanjit; Woo, Daniel; Lamba, Michael; Plas, David R; Paranjpe, Aditi; Roskin, Krishna; Zhao, Chuntao; Lu, Richard 2022. Chromatin structure predicts survival in glioma patients. Scientific reports, 12 1, 8221Karve, Aniruddha S; Desai, Janki M; Dave, Nimita; Wise-Draper, Trisha M; Gudelsky, Gary A; Phoenix, Timothy N; DasGupta, Biplab; Sengupta, Soma; Plas, David R; Desai, Pankaj B 2022. Potentiation of temozolomide activity against glioblastoma cells by aromatase inhibitor letrozole. Cancer chemotherapy and pharmacology, 90 4, 345-356Bischoff, Megan E; Zang, Yuanwei; Chu, Johnson; Price, Adam D; Ehmer, Birgit; Talbot, Nicholas J; Newbold, Michael J; Paul, Anurag; Guan, Jun-Lin; Plas, David R; Meller, Jarek; Czyzyk-Krzeska, Maria F 2021. Selective MAP1LC3C (LC3C) autophagy requires noncanonical regulators and the C-terminal peptide. The Journal of cell biology, 220 7, Czyzyk-Krzeska, Maria F; Landero Figueroa, Julio A; Gulati, Shuchi; Cunningham, John T; Meller, Jarek; ShamsaeI, Behrouz; Vemuri, Bhargav; Plas, David R 2021. Molecular and Metabolic Subtypes in Sporadic and Inherited Clear Cell Renal Cell Carcinoma. Genes, 12 3, Czyzyk-Krzeska, Maria F; Meller, Jarek; Landero Figueroa, Julio A; Plas, David R; Cunningham, John T 2021. Metabolic subtypes of clear cell renal cell carcinoma defined by tobacco smoking. Molecular & cellular oncology, 8 2, 1859917Koehler, Abigail; Karve, Aniruddha; Desai, Pankaj; Arbiser, Jack; Plas, David R; Qi, Xiaoyang; Read, Renee D; Sasaki, Atsuo T; Gawali, Vaibhavkumar S; Toukam, Donatien K; Bhattacharya, Debanjan; Kallay, Laura; Pomeranz Krummel, Daniel A; Sengupta, Soma 2021. Reuse of Molecules for Glioblastoma Therapy. Pharmaceuticals (Basel, Switzerland), 14 2, Qing, Ying; Dong, Lei; Gao, Lei; Li, Chenying; Li, Yangchan; Han, Li; Prince, Emily; Tan, Brandon; Deng, Xiaolan; Wetzel, Collin; Shen, Chao; Gao, Min; Chen, Zhenhua; Li, Wei; Zhang, Bin; Braas, Daniel; Ten Hoeve, Johanna; Sanchez, Gerardo Javier; Chen, Huiying; Chan, Lai N; Chen, Chun-Wei; Ann, David; Jiang, Lei; Müschen, Markus; Marcucci, Guido; Plas, David R; Li, Zejuan; Su, Rui; Chen, Jianjun 2021. R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m6A/PFKP/LDHB axis. Molecular cell, 81 5, 922-939.e9Reigle, James; Secic, Dina; Biesiada, Jacek; Wetzel, Collin; Shamsaei, Behrouz; Chu, Johnson; Zang, Yuanwei; Zhang, Xiang; Talbot, Nicholas J; Bischoff, Megan E; Zhang, Yongzhen; Thakar, Charuhas V; Gaitonde, Krishnanath; Sidana, Abhinav; Bui, Hai; Cunningham, John T; Zhang, Qing; Schmidt, Laura S; Linehan, W Marston; Medvedovic, Mario; Plas, David R; Figueroa, Julio A Landero; Meller, Jarek; Czyzyk-Krzeska, Maria F 2021. Tobacco smoking induces metabolic reprogramming of renal cell carcinoma. The Journal of clinical investigation, 131 1, Wang, Chenran; Haas, Michael A; Yeo, Syn Kok; Paul, Ritama; Yang, Fuchun; Vallabhapurapu, Subrahmanya; Qi, Xiaoyang; Plas, David R; Guan, Jun-Lin 2021. Autophagy mediated lipid catabolism facilitates glioma progression to overcome bioenergetic crisis. British journal of cancer, , Ren, Yan; Sivaganesan, Siva; Clark, Nicholas A; Zhang, Lixia; Biesiada, Jacek; Niu, Wen; Plas, David R; Medvedovic, Mario 2020. Predicting mechanism of action of cellular perturbations with pathway activity signatures. Bioinformatics (Oxford, England), , Sarma, Pranjal; Plas, David R 2020. Choreography of methylation: KDM4C histone demethylation enables ALKBH5 m6A RNA demethylation to sustain AML stem cells. Blood science (Baltimore, Md.), 2 4, 144-145Sliz, Anna; Locker, Kathryn C S; Lampe, Kristin; Godarova, Alzbeta; Plas, David R; Janssen, Edith M; Jones, Helen; Herr, Andrew B; Hoebe, Kasper 2019. Gab3 is required for IL-2- and IL-15-induced NK cell expansion and limits trophoblast invasion during pregnancy. Science immunology, 4 38, Wang, Chenran; Haas, Michael A; Yang, Fuchun; Yeo, Syn; Okamoto, Takako; Chen, Song; Wen, Jian; Sarma, Pranjal; Plas, David R; Guan, Jun-Lin 2019. Autophagic lipid metabolism sustains mTORC1 activity in TSC-deficient neural stem cells. Nature metabolism, 1 11, 1127-1140Su, Rui; Dong, Lei; Li, Chenying; Nachtergaele, Sigrid; Wunderlich, Mark; Qing, Ying; Deng, Xiaolan; Wang, Yungui; Weng, Xiaocheng; Hu, Chao; Yu, Mengxia; Skibbe, Jennifer; Dai, Qing; Zou, Dongling; Wu, Tong; Yu, Kangkang; Weng, Hengyou; Huang, Huilin; Ferchen, Kyle; Qin, Xi; Zhang, Bin; Qi, Jun; Sasaki, Atsuo T; Plas, David R; Bradner, James E; Wei, Minjie; Marcucci, Guido; Jiang, Xi; Mulloy, James C; Jin, Jie; He, Chuan; Chen, Jianjun 2018. R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling. Cell, 172 1-2, 90-105.e23Berman, Adi Y; Manna, Subrata; Schwartz, Naomi S; Katz, Yardena E; Sun, Yang; Behrmann, Catherine A; Yu, Jane J; Plas, David R; Alayev, Anya; Holz, Marina K 2017. ERRα regulates the growth of triple-negative breast cancer cells via S6K1-dependent mechanism. Signal transduction and targeted therapy, 2 , Li, Chenggang; Liu, Xiaolei; Liu, Yang; Zhang, Erik; Medepalli, Kantha; Masuda, Kohei; Li, Na; Kopras, Elizabeth J; Kwiatkowski, David J; Borchers, Michael T; Wikenheiser-Brokamp, Kathryn A; Osterburg, Andrew; Mays, Maxwell; Sun, Yang; Plas, David R; Sun, Julia L; Franz, David N; Capal, Jamie K; Alayev, Anya; Holz, Marina K; Krueger, Darcy A; Siroky, Brian J; Yu, Jane J 2017. Tuberin Regulates Prostaglandin Receptor-mediated Viability, via Rheb, in mTORC1-hyperactive Cells. Molecular cancer research : MCR, , Liu, Hongqi; Feng, Xizhi; Ennis, Kelli N; Behrmann, Catherine A; Sarma, Pranjal; Jiang, Tony T; Kofuji, Satoshi; Niu, Liang; Stratton, Yiwen; Thomas, Hala Elnakat; Yoon, Sang-Oh; Sasaki, Atsuo T; Plas, David R 2017. Pharmacologic Targeting of S6K1 in PTEN-Deficient Neoplasia. Cell reports, 18 9, 2088-2095Orr-Asman, Melissa A; Chu, Zhengtao; Jiang, Min; Worley, Mariah; LaSance, Kathleen; Koch, Sheryl E; Carreira, Vinicius S; Dahche, Hanan M; Plas, David R; Komurov, Kakajan; Qi, Xiaoyang; Mercer, Carol A; Anthony, Lowell B; Rubinstein, Jack; Thomas, Hala E 2017. mTOR Kinase Inhibition Effectively Decreases Progression of a Subset of Neuroendocrine Tumors that Progress on Rapalog Therapy and Delays Cardiac Impairment. Molecular cancer therapeutics, 16 11, 2432-2441Yoon, Sang-Oh; Shin, Sejeong; Karreth, Florian A; Buel, Gwen R; Jedrychowski, Mark P; Plas, David R; Dedhar, Shoukat; Gygi, Steven P; Roux, Philippe P; Dephoure, Noah; Blenis, John 2017. Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition. Molecular cell, , Ghosh, Joydeep; Kobayashi, Michihiro; Ramdas, Baskar; Chatterjee, Anindya; Ma, Peilin; Mali, Raghuveer Singh; Carlesso, Nadia; Liu, Yan; Plas, David R; Chan, Rebecca J; Kapur, Reuben 2016. S6K1 regulates hematopoietic stem cell self-renewal and leukemia maintenance. The Journal of clinical investigation, 126 7, 2621-5Shin, Sejeong; Buel, Gwen R; Wolgamott, Laura; Plas, David R; Asara, John M; Blenis, John; Yoon, Sang-Oh 2015. ERK2 Mediates Metabolic Stress Response to Regulate Cell Fate. Molecular cell, 59 3, 382-98Vallabhapurapu, Subrahmanya D; Noothi, Sunil K; Pullum, Derek A; Lawrie, Charles H; Pallapati, Rachel; Potluri, Veena; Kuntzen, Christian; Khan, Sohaib; Plas, David R; Orlowski, Robert Z; Chesi, Marta; Kuehl, W Michael; Bergsagel, P Leif; Karin, Michael; Vallabhapurapu, Sivakumar 2015. Transcriptional repression by the HDAC4-RelB-p52 complex regulates multiple myeloma survival and growth. Nature communications, 6 , 8428Hall, Daniel P; Cost, Nicholas G; Hegde, Shailaja; Kellner, Emily; Mikhaylova, Olga; Stratton, Yiwen; Ehmer, Birgit; Abplanalp, William A; Pandey, Raghav; Biesiada, Jacek; Harteneck, Christian; Plas, David R; Meller, Jarek; Czyzyk-Krzeska, Maria F 2014. TRPM3 and miR-204 establish a regulatory circuit that controls oncogenic autophagy in clear cell renal cell carcinoma. Cancer cell, 26 5, 738-53Unruh, Dusten; Turner, Kevin; Srinivasan, Ramprasad; Kocatürk, Begüm; Qi, Xiaoyang; Chu, Zhengtao; Aronow, Bruce J; Plas, David R; Gallo, Catherine A; Kalthoff, Holger; Kirchhofer, Daniel; Ruf, Wolfram; Ahmad, Syed A; Lucas, Fred V; Versteeg, Henri H; Bogdanov, Vladimir Y 2014. Alternatively spliced tissue factor contributes to tumor spread and activation of coagulation in pancreatic ductal adenocarcinoma. International journal of cancer. Journal international du cancer, 134 1, 9-20Barger, JF; Gallo, CA; Tandon, P; Liu, H; Sullivan, A; Grimes, HL; Plas, DR 2013. S6K1 determines the metabolic requirements for BCR-ABL survival Oncogene, 32 4, 453-61Ma, Li; Tao, Yongzhen; Duran, Angeles; Llado, Victoria; Galvez, Anita; Barger, Jennifer F; Castilla, Elias A; Chen, Jing; Yajima, Tomoko; Porollo, Aleksey; Medvedovic, Mario; Brill, Laurence M; Plas, David R; Riedl, Stefan J; Leitges, Michael; Diaz-Meco, Maria T; Richardson, Adam D; Moscat, Jorge 2013. Control of nutrient stress-induced metabolic reprogramming by PKC? in tumorigenesis. Cell, 152 3, 599-611Raynor, Jana; Sholl, Allyson; Plas, David R; Bouillet, Philippe; Chougnet, Claire A; Hildeman, David A 2013. IL-15 Fosters Age-Driven Regulatory T Cell Accrual in the Face of Declining IL-2 Levels. Frontiers in immunology, 4 , 161Aksoylar H, Lampe K, Barnes M, Plas DR, Hoebe K 2012. Loss of immunological tolerance in Gimap5-deficient mice is associated with loss of Foxo transcription factor expression in CD4+ lymphocytes Journal of Immunology, 188 1, 146Aksoylar, H Ibrahim; Lampe, Kristin; Barnes, Michael J; Plas, David R; Hoebe, Kasper 2012. Loss of immunological tolerance in Gimap5-deficient mice is associated with loss of Foxo in CD4+ T cells. Journal of immunology (Baltimore, Md. : 1950), 188 1, 146-54Czyzyk-Krzeska, Maria F; Meller, Jarek; Plas, David R 2012. Not all autophagy is equal. Autophagy, 8 7, 1155-6Mikhaylova, Olga; Stratton, Yiwen; Hall, Daniel; Kellner, Emily; Ehmer, Birgit; Drew, Angela F; Gallo, Catherine A; Plas, David R; Biesiada, Jacek; Meller, Jarek; Czyzyk-Krzeska, Maria F 2012. VHL-regulated MiR-204 suppresses tumor growth through inhibition of LC3B-mediated autophagy in renal clear cell carcinoma. Cancer cell, 21 4, 532-46Barger JF, Gallo CA, Torni KA, Merk L, Seibel WL, Nelson S, Plas DR 2011. Identification of Akt-selective cytotoxic compounds that enhance cytotoxic responses to rapamycin Cancer Biology & Therapy, 10 12, 1256Chougnet CA, Tripathi P, Lages CS, Raynor J, Sholl A, Fink P, Plas DR, Hildeman DA 2011. A major role for Bim in regulatory T cell homeostasis Journal of Immunology, 186 1, 156Chougnet, Claire A; Tripathi, Pulak; Lages, Celine S; Raynor, Jana; Sholl, Allyson; Fink, Pamela; Plas, David R; Hildeman, David A 2011. A major role for Bim in regulatory T cell homeostasis. Journal of immunology (Baltimore, Md. : 1950), 186 1, 156-63Coloff JL, MacIntyre AN, Nichols AN, Liu T, Gallo CA, Plas DR, Rathmell JC 2011. Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition Cancer Research, 71 15, 5204Coloff, Jonathan L; Macintyre, Andrew N; Nichols, Amanda G; Liu, Tingyu; Gallo, Catherine A; Plas, David R; Rathmell, Jeffrey C 2011. Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition. Cancer research, 71 15, 5204-13Giridhar PV, Funk HM, Gallo CA, Porollo A, Mercer CA, Plas DR, Drew AF 2011. Interleukin-6 receptor enhances early colonization of the murine omentum by upregulation of a mannose family receptor, LY75, in ovarian tumor cells Clinical and Experimental Metastasis, 28 8, 887Giridhar, Premkumar Vummidi; Funk, Holly M; Gallo, Catherine A; Porollo, Aleksey; Mercer, Carol A; Plas, David R; Drew, Angela F 2011. Interleukin-6 receptor enhances early colonization of the murine omentum by upregulation of a mannose family receptor, LY75, in ovarian tumor cells. Clinical & experimental metastasis, 28 8, 887-97Sommermann T, O’Neill , Plas DR, and Cahir-McFarland E 2011. IKKβ and NFκB transcription govern AKT-induced GLUT1 plasma membrane trafficking in B-lymphocytes Cancer Research, 71 23, 7291Sommermann, Thomas G; O'Neill, Kathleen; Plas, David R; Cahir-McFarland, Ellen 2011. IKK? and NF-?B transcription govern lymphoma cell survival through AKT-induced plasma membrane trafficking of GLUT1. Cancer research, 71 23, 7291-300Tandon P, Gallo CA, Khatri S, Barger, JF, Yepiskoposyan H, Plas DR 2011. Requirement for S6K1 to mediate glycolysis and apoptosis resistance induced by Pten-deficiency Proceedings of the National Academy of Sciences (USA), 108 6, 2361Tandon, Preeti; Gallo, Catherine A; Khatri, Shikha; Barger, Jennifer F; Yepiskoposyan, Hasmik; Plas, David R 2011. Requirement for ribosomal protein S6 kinase 1 to mediate glycolysis and apoptosis resistance induced by Pten deficiency. Proceedings of the National Academy of Sciences of the United States of America, 108 6, 2361-5Zhang Y, Johansson E, Miller ML, Jänicke RU, Ferguson DJ, Plas D, Meller J, Anderson MW 2011. Identification of a Conserved Anti-apoptotic Protein that Modulates the Mitochondrial Apoptosis Pathway Plos One, 6 9, e25284Barger JF, Plas DR 2010. Balancing biosynthesis and bioenergetics: metabolic programs in oncogenesis Endocrine-related cancer, , Barger, Jennifer F; Gallo, Catherine A; Torni, Kyle A; Merk, Lisa; Seibel, William L; Nelson, Sandra; Plas, David R 2010. Identification of Akt-selective cytotoxic compounds that enhance cytotoxic responses to rapamycin. Cancer biology & therapy, 10 12, 1256-61Khatri S, Yepiskoposyan H, Gallo CA, Tandon P, Plas DR 2010. FOXO3a regulates glycolysis via transcriptional control of tumor suppressor TSC1 The Journal of biological chemistry, 285 21, 15960-5Khatri S, Plas DR 2009. Targeting bioenergetics to enhance cancer chemotherapy: mitochondria SLP into apoptosis Cancer biology & therapy, 8 17, 1659-61Plas DR, Thomas G 2009. Tubers and tumors: rapamycin therapy for benign and malignant tumors Current opinion in cell biology, 21 2, 230-6Jones, Russell G; Plas, David R; Kubek, Sara; Buzzai, Monica; Mu, James; Xu, Yang; Birnbaum, Morris J; Thompson, Craig B 2005. AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Molecular cell, 18 3, 283-93Plas, David R; Thompson, Craig B 2005. Akt-dependent transformation: there is more to growth than just surviving. Oncogene, 24 50, 7435-42Arsham, Andrew M; Plas, David R; Thompson, Craig B; Simon, M Celeste 2004. Akt and hypoxia-inducible factor-1 independently enhance tumor growth and angiogenesis. Cancer research, 64 10, 3500-7Bauer, Daniel E; Harris, Marian H; Plas, David R; Lum, Julian J; Hammerman, Peter S; Rathmell, Jeffrey C; Riley, James L; Thompson, Craig B 2004. Cytokine stimulation of aerobic glycolysis in hematopoietic cells exceeds proliferative demand. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 18 11, 1303-5Elstrom, Rebecca L; Bauer, Daniel E; Buzzai, Monica; Karnauskas, Robyn; Harris, Marian H; Plas, David R; Zhuang, Hongming; Cinalli, Ryan M; Alavi, Abass; Rudin, Charles M; Thompson, Craig B 2004. Akt stimulates aerobic glycolysis in cancer cells. Cancer research, 64 11, 3892-9Karnauskas, Robyn; Niu, Qun; Talapatra, Sunit; Plas, David R; Greene, Marianne E; Crispino, John D; Rudin, Charles M 2003. Bcl-x(L) and Akt cooperate to promote leukemogenesis in vivo. Oncogene, 22 5, 688-98Plas, David R; Thompson, Craig B 2003. Akt activation promotes degradation of tuberin and FOXO3a via the proteasome. The Journal of biological chemistry, 278 14, 12361-6Rathmell, Jeffrey C; Fox, Casey J; Plas, David R; Hammerman, Peter S; Cinalli, Ryan M; Thompson, Craig B 2003. Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. Molecular and cellular biology, 23 20, 7315-28Arsham, Andrew M; Plas, David R; Thompson, Craig B; Simon, M Celeste 2002. Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1 alpha nor sufficient for HIF-1-dependent target gene transcription. The Journal of biological chemistry, 277 17, 15162-70Frauwirth, Kenneth A; Riley, James L; Harris, Marian H; Parry, Richard V; Rathmell, Jeffrey C; Plas, David R; Elstrom, Rebecca L; June, Carl H; Thompson, Craig B 2002. The CD28 signaling pathway regulates glucose metabolism. Immunity, 16 6, 769-77Plas, David R; Rathmell, Jeffrey C; Thompson, Craig B 2002. Homeostatic control of lymphocyte survival: potential origins and implications. Nature immunology, 3 6, 515-21Plas, David R; Thompson, Craig B 2002. Cell metabolism in the regulation of programmed cell death. Trends in endocrinology and metabolism: TEM, 13 2, 75-8Plas, D R; Talapatra, S; Edinger, A L; Rathmell, J C; Thompson, C B 2001. Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology. The Journal of biological chemistry, 276 15, 12041-8Vander Heiden, M G; Plas, D R; Rathmell, J C; Fox, C J; Harris, M H; Thompson, C B 2001. Growth factors can influence cell growth and survival through effects on glucose metabolism. Molecular and cellular biology, 21 17, 5899-912Dustin, L B; Plas, D R; Wong, J; Hu, Y T; Soto, C; Chan, A C; Thomas, M L 1999. Expression of dominant-negative src-homology domain 2-containing protein tyrosine phosphatase-1 results in increased Syk tyrosine kinase activity and B cell activation. Journal of immunology (Baltimore, Md. : 1950), 162 5, 2717-24Plas, D R; Williams, C B; Kersh, G J; White, L S; White, J M; Paust, S; Ulyanova, T; Allen, P M; Thomas, M L 1999. Cutting edge: the tyrosine phosphatase SHP-1 regulates thymocyte positive selection. Journal of immunology (Baltimore, Md. : 1950), 162 10, 5680-4Wang, L L; Blasioli, J; Plas, D R; Thomas, M L; Yokoyama, W M 1999. Specificity of the SH2 domains of SHP-1 in the interaction with the immunoreceptor tyrosine-based inhibitory motif-bearing receptor gp49B. Journal of immunology (Baltimore, Md. : 1950), 162 3, 1318-23Plas, D R; Thomas, M L 1998. Negative regulation of antigen receptor signaling in lymphocytes. Journal of molecular medicine (Berlin, Germany), 76 8, 589-95Matsumoto, M; Lo, S F; Carruthers, C J; Min, J; Mariathasan, S; Huang, G; Plas, D R; Martin, S M; Geha, R S; Nahm, M H; Chaplin, D D 1996. Affinity maturation without germinal centres in lymphotoxin-alpha-deficient mice. Nature, 382 6590, 462-6Plas, D R; Johnson, R; Pingel, J T; Matthews, R J; Dalton, M; Roy, G; Chan, A C; Thomas, M L 1996. Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling. Science (New York, N.Y.), 272 5265, 1173-6Moe, A J; Plas, D R; Powell, K A; Smith, C H . Riboflavin uptake in microvillous and basal membrane vesicles isolated from full-term human placentas. Placenta, 15 2, 137-46