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Photo of  Phillip Owens, PhD

Phillip Owens, PhD

Associate Professor

Internal Medicine | College of Medicine

  • Doctoral Degree: University of Kentucky
Contact Information
Research Interests

The primary focus of my research is to examine the effects of coagulation proteins, proteases, and receptors in the pathogenesis cardiovascular disease (CVD), specifically atherosclerosis and abdominal aortic aneurysms (AAAs).  We utilize genetically modified mice and mouse models of disease to generate data and attempt to verify these results in the human condition, when possible, with retrospective clinical data or human specimens.  While several drug therapies exist for atherosclerosis, there...

Peer Reviewed Publications

Green, Lisa C; Anthony, Sarah R; Slone, Samuel; Lanzillotta, Lindsey; Nieman, Michelle L; Wu, Xiaoqing; Robbins, Nathan; Jones, Shannon M; Roy, Sudeshna; Owens, A Phillip; Aube, Jeffrey; Xu, Liang; Lorenz, John N; Blaxall, Burns C; Rubinstein, Jack; Benoit, Joshua B; Tranter, Michael 2019. Human antigen R as a therapeutic target in pathological cardiac hypertrophy. JCI insight, 4 4,

Posma, Jens J; Grover, Steven P; Hisada, Yohei; Owens, A Phillip; Antoniak, Silvio; Spronk, Henri M; Mackman, Nigel 2019. Roles of Coagulation Proteases and PARs (Protease-Activated Receptors) in Mouse Models of Inflammatory Diseases. Arteriosclerosis, thrombosis, and vascular biology, 39 1, 13-24

Cameron, Scott J; Russell, Hannah M; Owens, A Phillip 2018. Antithrombotic therapy in abdominal aortic aneurysm: beneficial or detrimental? Blood, 132 25, 2619-2628

Jones, Shannon M; Mann, Adrien; Conrad, Kelsey; Saum, Keith; Hall, David E; McKinney, Lisa M; Robbins, Nathan; Thompson, Joel; Peairs, Abigail D; Camerer, Eric; Rayner, Katey J; Tranter, Michael; Mackman, Nigel; Owens, A Phillip 2018. PAR2 (Protease-Activated Receptor 2) Deficiency Attenuates Atherosclerosis in Mice. Arteriosclerosis, thrombosis, and vascular biology, 38 6, 1271-1282

Owens, A Phillip; Robbins, Nathan; Saum, Keith; Jones, Shannon M; Kirschner, Akiva; Woo, Jessica G; McCoy, Connie; Slone, Samuel; Rothenberg, Marc E; Urbina, Elaine M; Tranter, Michael; Rubinstein, Jack 2018. Tefillin use induces remote ischemic preconditioning pathways in healthy men. American journal of physiology. Heart and circulatory physiology, 315 6, H1748-H1758

Sundermann, Alexandra C; Saum, Keith; Conrad, Kelsey A; Russell, Hannah M; Edwards, Todd L; Mani, Kevin; Björck, Martin; Wanhainen, Anders; Owens, A Phillip 2018. Prognostic value of D-dimer and markers of coagulation for stratification of abdominal aortic aneurysm growth. Blood advances, 2 22, 3088-3096

Kopec, Anna K; Abrahams, Sara R; Thornton, Sherry; Palumbo, Joseph S; Mullins, Eric S; Divanovic, Senad; Weiler, Hartmut; Owens, A Phillip; Mackman, Nigel; Goss, Ashley; van Ryn, Joanne; Luyendyk, James P; Flick, Matthew J 2017. Thrombin promotes diet-induced obesity through fibrin-driven inflammation. The Journal of clinical investigation, 127 8, 3152-3166

Boulaftali, Yacine; Owens, A Phillip; Beale, Ashley; Piatt, Raymond; Casari, Caterina; Lee, Robert H; Conley, Pamela B; Paul, David S; Mackman, Nigel; Bergmeier, Wolfgang 2016. CalDAG-GEFI Deficiency Reduces Atherosclerotic Lesion Development in Mice. Arteriosclerosis, thrombosis, and vascular biology, 36 5, 792-9

Rautou, Pierre-Emmanuel; Tatsumi, Kohei; Antoniak, Silvio; Owens, A Phillip; Sparkenbaugh, Erica; Holle, Lori A; Wolberg, Alisa S; Kopec, Anna K; Pawlinski, Rafal; Luyendyk, James P; Mackman, Nigel 2016. Hepatocyte tissue factor contributes to the hypercoagulable state in a mouse model of chronic liver injury. Journal of hepatology, 64 1, 53-9

Østerud, B; Unruh, D; Olsen, J O; Kirchhofer, D; Owens, A P; Bogdanov, V Y 2015. Procoagulant and proinflammatory effects of red blood cells on lipopolysaccharide-stimulated monocytes. Journal of thrombosis and haemostasis : JTH, 13 9, 1676-82

Owens, A Phillip; Edwards, Todd L; Antoniak, Silvio; Geddings, Julia E; Jahangir, Eiman; Wei, Wei-Qi; Denny, Joshua C; Boulaftali, Yacine; Bergmeier, Wolfgang; Daugherty, Alan; Sampson, Uchechukwu K A; Mackman, Nigel 2015. Platelet Inhibitors Reduce Rupture in a Mouse Model of Established Abdominal Aortic Aneurysm. Arteriosclerosis, thrombosis, and vascular biology, 35 9, 2032-41

Antoniak SA, Owens P, Baunacke M, Williams JC, Lee RD, Weithaeuser A, Sheridan PA, Malz R, Luyendyk JP, Esserman DA, Trejo J, Blaxall BC, Pawlinski R, Beck MA, Rauch U, Mackman N 2013. PAR-1 Contributes to the Innate Immune Response During Viral Infection The Journal of Clinical Investigation, 123 3, 1310

Boulaftali Y, Hess PR, Getz TM, Cholka A, Stolla M, Mackman N, Owens AP, Ware J, Kahn ML, Bergmeier W 2013. Platelet ITAM Signaling is Critical for Vascular Integrity in Inflammation. The Journal of Clinical Investigation, 123 2, 908

Sweet DT, Chen Z, Givens CS, Owens AP, Rojas M, Tzima E 2013. Endothelial Shc Regulates Arteriogenesis Through Dual Control of Arterial Specification and Inflammation via the Notch and NF-κB Pathways. Circulation Research, 113 1, 32

Aruna Poduri, A. Phillip Owens III, Deborah A. Howatt, Jessica J. Moorleghen, Anju Balakrishnan, Lisa A. Cassis, and Alan Daugherty 2012. Regional Variation in Aortic AT1b Receptor mRNA Abundance is Associated with Contractility but Unrelated to Atherosclerosis and Aortic Aneurysms PLoS One, 7 10, e48462

Owens AP, Passam FH, Antoniak S, Marshall SM, McDaniel AL, Rudel L, Williams JC, Hubbard BK, Dutton J, Wang J, Tobias PS, Curtiss LK, Daugherty A, Kirchhofer D, Luyendyk JP, Moriarty PM, Nagarajan S, Furie BC, Furie B, Johns DG, Temel RE, Mackman N 2012. Monocyte Tissue Factor-dependent Activation of coagulation in Hypercholesterolemic Mice and Monkeys is Inhibited by Simvastatin. The Journal of Clinical Investigation, 122 2, 558

Owens AP, Howatt DA, Moore KJ, Tobias PS, Curtiss LA, Cassis LA, Daugherty A 2011. MyD88 Deficiency Attenuates Angiotensin II-induced Abdominal Aortic Aneurysm Formation Independent of Signaling Through Toll-like Receptors 2 and 4 Arteriosclerosis, Thrombosis, and Vascular Biology, 12 , 2813

Daugherty A.;Tall A.;Daemen M.;Falk E.;Fisher E.;García-Cardeña G.;Lusis A.;Owens A.;Rosenfeld M.;Virmani R. 09-01-2017. Recommendation on design, execution, and reporting of animal atherosclerosis studies: A scientific s Circulation Research, 121 6, e53-e79

Daugherty A.;Tall A.R.;Daemen M.J.A.P.;Falk E.;Fisher E.A.;García-Cardeña G.;Lusis A.J.;Owens A.P.;Rosenfeld M.E.;Virmani R. 09-01-2017. Recommendation on Design, Execution, and Reporting of Animal Atherosclerosis Studies: A Scientific S Arteriosclerosis, Thrombosis, and Vascular Biology, 37 9, e131-e157

Saum K.;Campos B.;Celdran-Bonafonte D.;Nayak L.;Sangwung P.;Thakar C.;Roy-Chaudhury P.;Owens A. 01-01-2018. Uremic advanced glycation end products and protein-bound solutes induce endothelial dysfunction thro Journal of the American Heart Association, 7 1,

Owens A.P.;MacKman N. 01-01-2012. Sources of tissue factor that contribute to thrombosis after rupture of an atherosclerotic plaque Thrombosis Research, 129 SUPPL. 2,