Today is Thursday, Dec. 12, 2019

Department of Environmental Health

Center for Environmental Genetics

Integrative Technologies Support Core

The purpose of the CEG Integrative Technologies Support Core (ITS) is to provide investigators with access to state-of-the-art instrumentation and technologies in a manner that enhances overall research effectiveness, cost effectiveness, and utilization of time and manpower. In the spirit of “not duplicating services,” the CEG has used a model of providing direct subsidies (see below) for CEG members to use technology cores/facilities already existing at UC and Cincinnati Children’s Hospital Medical Center. These include

Tier I  subsidies\matching funds up to $5,000
  • Genomics, Epigenomics and Sequencing Core & Genotyping  (Tier I)
  • Flow Cytometry (Tier I)
  • Confocal Microscopy (Tier I)

 

Tier II  subsidies\matching funds up to $2,000
  • Inhalation Core (Tier II)
  • Transgenic Animal and Genome Editing Core (Tier II) (CCHMC)
  • ProteomicsCore (Tier II) (UC)
  • NMR-based Metabolomics Core (Tier II)
  • Animal Behavioral Core (Tier II)
  • Fernald Community Cohort Resources (Tier II)
  • Pluripotent Stem Cell Facility (Tier II) (CCHMC)
  • Metallomics Core (Tier II)

 

Selection, stratification and continuation of a core/facility are based on (1) current and anticipated usage, (2) quality of services provided, (3) the technological novelty and the investigative power of the services provided, and (4) consistency with the vision of the CEG to integrate basic, translational and clinical EHS research for the betterment of human health. Cores/facilities may be added, re-tiered, or removed based on the these criteria.

The majority of the ITS budget is to be used in the form of in-kind subsidies to allow members to leverage NIH/NIEHS- or foundation-funded EHS research. Recipients of CEG Pilot awards can use their awards as matching funds for qualified, subsidized services. The remaining portion of the budget pays for expert advice offered by selected core/facility leaders or key personnel who will provide pre-experimental or pre-grant application consultations.

To apply for an ITS subsidy, please provide all details required on the following application form and submit in c/o the CEG program director. Applications must include a written cost quote from the core manager\services provider. To download a fillable Word form, click here.  PDF form, click here.

All requests must be relevant to the mission of the CEG and the study of gene-environment interactions (GxE).  “Gene” in this context is broadly defined: i.e., individual genes/gene components, gene products, genomics, functional genomics, proteomics, metabolomics, epigenomics. “Environment” in this context is defined based on the language used by the NIEHS for environmentally relevant toxicants:

Examples of environmentally relevant toxicants include industrial chemicals or manufacturing byproducts, metals, pesticides, herbicides, air pollutants and other inhaled toxicants, particulates or fibers, and fungal/bacterial or biologically derived toxins. Agents considered non-responsive include, but are not limited to: alcohol, drugs of abuse, pharmaceuticals, chemotherapeutic agents, radiation which is not a result of an ambient environmental exposure, and infectious or parasitic agents, except when agents are disease co-factors to an environmental toxicant exposure to produce the biological effect.... However, it is appropriate to include these factors as part of research to define effects of the exposome, and these factors may be a part of applications focused on the totality of a person’s environmental exposure.  [our emphasis added]

Note that, while environmental tobacco smoke (secondhand smoke) is considered a fundable topic, (direct) smoking is not.

All requests that include use of human subjects or human specimens must include a consultation with the CEG Integrative Health Sciences Core by using the Research Central portal of the Center for Clinical and Translational Science and Training: https://cctst.uc.edu. When queried regarding project information, note project affiliation (if applicable) and indicate the Center for Environmental Genetics.

Research supported by the Center for Environmental Genetics should cite NIEHS P30-ES006096