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Department of

Surgery

Photo of  Charles Caldwell, PhD

Charles Caldwell, PhD

Professor of Surgery; Director, Division of Research

Education/Credentials
  • Bachelor's Degree: University of California - San Diego
  • Doctoral Degree: San Diego State University
  • Postdoctoral Training: National Institutes of Health
Contact Information
  • Medical Sciences Building
  • SRU Room G479
  • 231 Albert Sabin Way
  • Cincinnati, Ohio 45267
  • Office 513-558-1974
  • Email charles.caldwell@uc.edu

Peer Reviewed Publications

Hoehn, Richard S; Jernigan, Peter L; Chang, Alex L; Edwards, Michael J; Caldwell, Charles C; Gulbins, Erich; Pritts, Timothy A 2016. Acid Sphingomyelinase Inhibition Prevents Hemolysis During Erythrocyte Storage. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 39 1, 331-40

Hoehn, Richard S; Jernigan, Peter L; Japtok, Lukasz; Chang, Alex L; Midura, Emily F; Caldwell, Charles C; Kleuser, Burkhard; Lentsch, Alex B; Edwards, Michael J; Gulbins, Erich; Pritts, Timothy A 2016. Acid Sphingomyelinase Inhibition in Stored Erythrocytes Reduces Transfusion-Associated Lung Inflammation. Annals of surgery, ,

Johnson, Bobby L; Rice, Teresa C; Xia, Brent T; Boone, Kirsten I; Green, Ellis A; Gulbins, Erich; Caldwell, Charles C 2016. Amitriptyline Usage Exacerbates the Immune Suppression Following Burn Injury. Shock (Augusta, Ga.), ,

Kuethe, Joshua W; Armocida, Stephanie M; Midura, Emily F; Rice, Teresa C; Hildeman, David A; Healy, Daniel P; Caldwell, Charles C 2016. Fecal Microbiota Transplant Restores Mucosal Integrity in a Murine Model of Burn Injury. Shock (Augusta, Ga.), 45 6, 647-52

Midura, Emily F; Kuethe, Joshua W; Rice, Teresa C; Veile, Rosalie; England, Lisa G; Friend, Lou Ann; Caldwell, Charles C; Goodman, Michael D 2016. Impact of Platelets and Platelet-Derived Microparticles on Hypercoagulability Following Burn Injury. Shock (Augusta, Ga.), 45 1, 82-7

Midura, Emily F; Prakash, Priya S; Johnson, Bobby L; Rice, Teresa C; Kunz, Natalia; Caldwell, Charles C 2016. Impact of caspase-8 and PKA in regulating neutrophil-derived microparticle generation. Biochemical and biophysical research communications, 469 4, 917-22

Rice, Teresa C; Seitz, Aaron P; Edwards, Michael J; Gulbins, Erich; Caldwell, Charles C 2016. Sphingosine rescues burn-injured mice from pulmonary Pseudomonas aeruginosa infection. Journal of leukocyte biology, ,

Kuethe, Joshua W; Midura, Emily F; Rice, Teresa C; Caldwell, Charles C 2015. Peritoneal wash contents used to predict mortality in a murine sepsis model. The Journal of surgical research, ,

Midura, Emily F; Jernigan, Peter L; Kuethe, Joshua W; Friend, Lou Ann; Veile, Rosalie; Makley, Amy T; Caldwell, Charles C; Goodman, Michael D 2015. Microparticles impact coagulation after traumatic brain injury. The Journal of surgical research, 197 1, 25-31

Siegl, Daniel; Midura, Emily F; Annecke, Thorsten; Conzen, Peter; Caldwell, Charles C; Tschoep, Johannes 2015. The effect of ghrelin upon the early immune response in lean and obese mice during sepsis. PloS one, 10 4, e0122211

Wang, Xiaohong; Gu, Haitao; Qin, Dongze; Yang, Liwang; Huang, Wei; Essandoh, Kobina; Wang, Yigang; Caldwell, Charles C; Peng, Tianqing; Zingarelli, Basilia; Fan, Guo-Chang 2015. Exosomal miR-223 Contributes to Mesenchymal Stem Cell-Elicited Cardioprotection in Polymicrobial Sepsis. Scientific reports, 5 , 13721

Wilson, Gregory C; Freeman, Christopher M; Kuethe, Joshua W; Quillin, Ralph C; Nojima, Hiroyuki; Schuster, Rebecca; Blanchard, John; Edwards, Michael J; Caldwell, Charles C; Lentsch, Alex B 2015. CXC chemokine receptor-4 signaling limits hepatocyte proliferation after hepatic ischemia-reperfusion in mice. American journal of physiology. Gastrointestinal and liver physiology, 308 8, G702-9

Freeman, Christopher M; Quillin, Ralph C; Wilson, Gregory C; Nojima, Hiroyuki; Johnson, Bobby L; Sutton, Jeffrey M; Schuster, Rebecca M; Blanchard, John; Edwards, Michael J; Caldwell, Charles C; Lentsch, Alex B 2014. Characterization of microparticles after hepatic ischemia-reperfusion injury. PloS one, 9 5, e97945

Johnson, Bobby L; Iii, ; Kuethe, Josh W; Caldwell, Charles C 2014. Neutrophil derived microvesicles: emerging role of a key mediator to the immune response. Endocrine, metabolic & immune disorders drug targets, 14 3, 210-7

Kuethe, Joshua W; Prakash, Priya S; Midura, Emily F; Johnson, Bobby L; Kasten, Kevin R; Caldwell, Charles C 2014. Thymic stromal lymphopoietin mediates the host response and increases mortality during sepsis. The Journal of surgical research, 191 1, 19-24

Lehmann, Christian; Sharawi, Nivin; Al-Banna, Nadia; Corbett, Nathan; Kuethe, Joshua W; Caldwell, Charles C 2014. Novel approaches to the development of anti-sepsis drugs. Expert opinion on drug discovery, 9 5, 523-31

Siegl, Daniel; Annecke, Thorsten; Johnson, Bobby L; Schlag, Christian; Martignoni, Andre; Huber, Nadine; Conzen, Peter; Caldwell, Charles C; Tschöp, Johannes 2014. Obesity-induced hyperleptinemia improves survival and immune response in a murine model of sepsis. Anesthesiology, 121 1, 98-114

Wang, Xiaohong; Huang, Wei; Yang, Yang; Wang, Yigang; Peng, Tianqing; Chang, Jiang; Caldwell, Charles C; Zingarelli, Basilia; Fan, Guo-Chang 2014. Loss of duplexmiR-223 (5p and 3p) aggravates myocardial depression and mortality in polymicrobial sepsis. Biochimica et biophysica acta, 1842 5, 701-11

Yang, Sung; Stepien, David; Hanseman, Dennis; Robinson, Bryce; Goodman, Michael D; Pritts, Timothy A; Caldwell, Charles C; Remick, Daniel G; Lentsch, Alex B 2014. Substance P mediates reduced pneumonia rates after traumatic brain injury. Critical care medicine, 42 9, 2092-100

Johnson, Bobby L; Goetzman, Holly S; Prakash, Priya S; Caldwell, Charles C 2013. Mechanisms underlying mouse TNF-? stimulated neutrophil derived microparticle generation. Biochemical and biophysical research communications, 437 4, 591-6

Van Sweringen, Heather L; Sakai, Nozomu; Quillin, Ralph C; Bailey, Jeff; Schuster, Rebecca; Blanchard, John; Goetzman, Holly; Caldwell, Charles C; Edwards, Michael J; Lentsch, Alex B 2013. Roles of hepatocyte and myeloid CXC chemokine receptor-2 in liver recovery and regeneration after ischemia/reperfusion in mice. Hepatology (Baltimore, Md.), 57 1, 331-8

Belizaire, Ritha M; Prakash, Priya S; Richter, Jillian R; Robinson, Bryce R; Edwards, Michael J; Caldwell, Charles C; Lentsch, Alex B; Pritts, Timothy A 2012. Microparticles from stored red blood cells activate neutrophils and cause lung injury after hemorrhage and resuscitation. Journal of the American College of Surgeons, 214 4, 648-55; discussion 6

Nowak, Jeffrey E; Harmon, Kelli; Caldwell, Charles C; Wong, Hector R 2012. Prophylactic zinc supplementation reduces bacterial load and improves survival in a murine model of sepsis. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 13 5, e323-9

Prakash, Priya S; Caldwell, Charles C; Lentsch, Alex B; Pritts, Timothy A; Robinson, Bryce R H 2012. Human microparticles generated during sepsis in patients with critical illness are neutrophil-derived and modulate the immune response. The journal of trauma and acute care surgery, 73 2, 401-6; discussion 40

Standage, Stephen W; Caldwell, Charles C; Zingarelli, Basilia; Wong, Hector R 2012. Reduced peroxisome proliferator-activated receptor ? expression is associated with decreased survival and increased tissue bacterial load in sepsis. Shock (Augusta, Ga.), 37 2, 164-9

Unsinger, Jacqueline; Burnham, Carey-Ann D; McDonough, Jacquelyn; Morre, Michel; Prakash, Priya S; Caldwell, Charles C; Dunne, W Michael; Hotchkiss, Richard S 2012. Interleukin-7 ameliorates immune dysfunction and improves survival in a 2-hit model of fungal sepsis. The Journal of infectious diseases, 206 4, 606-16

Caldwell, Charles C; Hotchkiss, Richard S 2011. The first step in utilizing immune-modulating therapies: immune status determination. Critical care (London, England), 15 1, 108

Clarke, Callisia; Kuboki, Satoshi; Sakai, Nozomu; Kasten, Kevin R; Tevar, Amit D; Schuster, Rebecca; Blanchard, John; Caldwell, Charles C; Edwards, Michael J; Lentsch, Alex B 2011. CXC chemokine receptor-1 is expressed by hepatocytes and regulates liver recovery after hepatic ischemia/reperfusion injury. Hepatology (Baltimore, Md.), 53 1, 261-71

Adediran, Samuel G; Dauplaise, Derrick J; Kasten, Kevin R; Tschöp, Johannes; Dattilo, Jonathan; Goetzman, Holly S; England, Lisa G; Cave, Cindy M; Robinson, Chad T; Caldwell, Charles C 2010. Early infection during burn-induced inflammatory response results in increased mortality and p38-mediated neutrophil dysfunction. American journal of physiology. Regulatory, integrative and comparative physiology, 299 3, R918-25

Kasten, Kevin R; Goetzman, Holly S; Reid, Maria R; Rasper, Alison M; Adediran, Samuel G; Robinson, Chad T; Cave, Cindy M; Solomkin, Joseph S; Lentsch, Alex B; Johannigman, Jay A; Caldwell, Charles C 2010. Divergent adaptive and innate immunological responses are observed in humans following blunt trauma. BMC immunology, 11 , 4

Kasten, Kevin R; Muenzer, Jared T; Caldwell, Charles C 2010. Neutrophils are significant producers of IL-10 during sepsis. Biochemical and biophysical research communications, 393 1, 28-31

Kasten, Kevin R; Prakash, Priya S; Unsinger, Jacqueline; Goetzman, Holly S; England, Lisa G; Cave, Cindy M; Seitz, Aaron P; Mazuski, Cristina N; Zhou, Tony T; Morre, Michel; Hotchkiss, Richard S; Hildeman, David A; Caldwell, Charles C 2010. Interleukin-7 (IL-7) treatment accelerates neutrophil recruitment through gamma delta T-cell IL-17 production in a murine model of sepsis. Infection and immunity, 78 11, 4714-22

Kasten, Kevin R; Tschöp, Johannes; Adediran, Samuel G; Hildeman, David A; Caldwell, Charles C 2010. T cells are potent early mediators of the host response to sepsis. Shock (Augusta, Ga.), 34 4, 327-36

Kasten, Kevin R; Tschöp, Johannes; Goetzman, Holly S; England, Lisa G; Dattilo, Jonathan R; Cave, Cindy M; Seitz, Aaron P; Hildeman, David A; Caldwell, Charles C 2010. T-cell activation differentially mediates the host response to sepsis. Shock (Augusta, Ga.), 34 4, 377-83

Kasten, Kevin Richard; Tschöp, Johannes; Tschöp, Matthias Hans; Caldwell, Charles Curtis 2010. The cannabinoid 2 receptor as a potential therapeutic target for sepsis. Endocrine, metabolic & immune disorders drug targets, 10 3, 224-34

Tschöp, Johannes; Dattilo, Jonathan R; Prakash, Priya S; Kasten, Kevin R; Tschöp, Matthias H; Caldwell, Charles C 2010. The leptin system: a potential target for sepsis induced immune suppression. Endocrine, metabolic & immune disorders drug targets, 10 4, 336-47

Tschöp, Johannes; Nogueiras, Ruben; Haas-Lockie, Sarah; Kasten, Kevin R; Castañeda, Tamara R; Huber, Nadine; Guanciale, Kelsey; Perez-Tilve, Diego; Habegger, Kirk; Ottaway, Nickki; Woods, Stephen C; Oldfield, Brian; Clarke, Iain; Chua, Streamson; Farooqi, I Sadaf; O'Rahilly, Stephen; Caldwell, Charles C; Tschöp, Matthias H 2010. CNS leptin action modulates immune response and survival in sepsis. The Journal of neuroscience : the official journal of the Society for Neuroscience, 30 17, 6036-47

Unsinger, Jacqueline; McGlynn, Margaret; Kasten, Kevin R; Hoekzema, Andrew S; Watanabe, Eizo; Muenzer, Jared T; McDonough, Jacquelyn S; Tschoep, Johannes; Ferguson, Thomas A; McDunn, Jonathan E; Morre, Michel; Hildeman, David A; Caldwell, Charles C; Hotchkiss, Richard S 2010. IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis. Journal of immunology (Baltimore, Md. : 1950), 184 7, 3768-79

Caldwell, Charles C; Chen, Yi; Goetzmann, Holly S; Hao, Yonghua; Borchers, Michael T; Hassett, Daniel J; Young, Lisa R; Mavrodi, Dmitri; Thomashow, Linda; Lau, Gee W 2009. Pseudomonas aeruginosa exotoxin pyocyanin causes cystic fibrosis airway pathogenesis. The American journal of pathology, 175 6, 2473-88

Hassett, Daniel J; Sutton, Mark D; Schurr, Michael J; Herr, Andrew B; Caldwell, Charles C; Matu, Joseph O 2009. Pseudomonas aeruginosa hypoxic or anaerobic biofilm infections within cystic fibrosis airways. Trends in microbiology, 17 3, 130-8

Kuboki, Satoshi; Sakai, Nozomu; Tschöp, Johannes; Edwards, Michael J; Lentsch, Alex B; Caldwell, Charles C 2009. Distinct contributions of CD4+ T cell subsets in hepatic ischemia/reperfusion injury. American journal of physiology. Gastrointestinal and liver physiology, 296 5, G1054-9

Tschöp, Johannes; Kasten, Kevin R; Nogueiras, Ruben; Goetzman, Holly S; Cave, Cynthia M; England, Lisa G; Dattilo, Jonathan; Lentsch, Alex B; Tschöp, Matthias H; Caldwell, Charles C 2009. The cannabinoid receptor 2 is critical for the host response to sepsis. Journal of immunology (Baltimore, Md. : 1950), 183 1, 499-505

Tschöp, Johannes; Martignoni, André; Reid, Maria D; Adediran, Samuel G; Gardner, Jason; Noel, Greg J; Ogle, Cora K; Neely, Alice N; Caldwell, Charles C 2009. Differential immunological phenotypes are exhibited after scald and flame burns. Shock (Augusta, Ga.), 31 2, 157-63

Caldwell, Charles C; Lentsch, Alex B 2008. Ischemia-driven expression of CD73 confers tissue protection during liver ischemia/reperfusion. Gastroenterology, 135 5, 1460-2

Caldwell, Charles C; Martignoni, Andre; Leonis, Mike A; Ondiveeran, Hari Kumar; Fox-Robichaud, Alison E; Waltz, Susan E 2008. Ron receptor tyrosine kinase-dependent hepatic neutrophil recruitment and survival benefit in a murine model of bacterial peritonitis. Critical care medicine, 36 5, 1585-93

Martignoni, André; Tschöp, Johannes; Goetzman, Holly S; Choi, Lisa G; Reid, Maria D; Johannigman, Jay A; Lentsch, Alex B; Caldwell, Charles C 2008. CD4-expressing cells are early mediators of the innate immune system during sepsis. Shock (Augusta, Ga.), 29 5, 591-7

Tschöp, Johannes; Martignoni, André; Goetzman, Holly S; Choi, Lisa G; Wang, Quan; Noel, John G; Ogle, Cora K; Pritts, Timothy A; Johannigman, Jay A; Lentsch, Alex B; Caldwell, Charles C 2008. Gammadelta T cells mitigate the organ injury and mortality of sepsis. Journal of leukocyte biology, 83 3, 581-8

Caldwell, Charles C; Tschoep, Johannes; Lentsch, Alex B 2007. Lymphocyte function during hepatic ischemia/reperfusion injury. Journal of leukocyte biology, 82 3, 457-64

Huang, Julie H; Cárdenas-Navia, L Isabel; Caldwell, Charles C; Plumb, Troy J; Radu, Caius G; Rocha, Paulo N; Wilder, Tuere; Bromberg, Jonathan S; Cronstein, Bruce N; Sitkovsky, Michail; Dewhirst, Mark W; Dustin, Michael L 2007. Requirements for T lymphocyte migration in explanted lymph nodes. Journal of immunology (Baltimore, Md. : 1950), 178 12, 7747-55

Noel, John G; Osterburg, Andrew; Wang, Quan; Guo, Xialing; Byrum, Denise; Schwemberger, Sandy; Goetzman, Holly; Caldwell, Charles C; Ogle, Cora K 2007. Thermal injury elevates the inflammatory monocyte subpopulation in multiple compartments. Shock (Augusta, Ga.), 28 6, 684-93

Thiel, Manfred; Caldwell, Charles C; Kreth, Simone; Kuboki, Satoshi; Chen, P; Smith, Patrick; Ohta, Akio; Lentsch, Alex B; Lukashev, Dmitry; Sitkovsky, Michail V 2007. Targeted deletion of HIF-1alpha gene in T cells prevents their inhibition in hypoxic inflamed tissues and improves septic mice survival. PloS one, 2 9, e853

Wetzel, Cynthia C; Leonis, Mike A; Dent, Arlene; Olson, Meredith A; Longmeier, Angela M; Ney, Paul A; Boivin, Greg P; Kader, Sarah A; Caldwell, Charles C; Degen, Sandra J F; Waltz, Susan E 2007. Short-form Ron receptor is required for normal IFN-gamma production in concanavalin A-induced acute liver injury. American journal of physiology. Gastrointestinal and liver physiology, 292 1, G253-61

Caldwell, Charles C; Okaya, Tomohisa; Martignoni, Andre; Husted, Thomas; Schuster, Rebecca; Lentsch, Alex B 2005. Divergent functions of CD4+ T lymphocytes in acute liver inflammation and injury after ischemia-reperfusion. American journal of physiology. Gastrointestinal and liver physiology, 289 5, G969-76

Noel, John G; Guo, Xialing; Wells-Byrum, Denise; Schwemberger, Sandy; Caldwell, Charles C; Ogle, Cora K 2005. Effect of thermal injury on splenic myelopoiesis. Shock (Augusta, Ga.), 23 2, 115-22

Okaya, Tomohisa; Blanchard, John; Schuster, Rebecca; Kuboki, Satoshi; Husted, Thomas; Caldwell, Charles C; Zingarelli, Basilia; Wong, Hector; Solomkin, Joseph S; Lentsch, Alex B 2005. Age-dependent responses to hepatic ischemia/reperfusion injury. Shock (Augusta, Ga.), 24 5, 421-7

Lukashev, Dmitriy E; Caldwell, Charles C; Chen, Pearl; Apasov, Sergey G; Margulies, David H; Sitkovsky, Michail V 2003. A serine/threonine phosphorylation site in the ectodomain of a T cell receptor beta chain is required for activation by superantigen. Journal of receptor and signal transduction research, 23 1, 33-52

Lukashev, Dmitriy E; Smith, Patrick T; Caldwell, Charles C; Ohta, Akio; Apasov, Sergey G; Sitkovsky, Michail V 2003. Analysis of A2a receptor-deficient mice reveals no significant compensatory increases in the expression of A2b, A1, and A3 adenosine receptors in lymphoid organs. Biochemical pharmacology, 65 12, 2081-90

Olah, Mark E; Caldwell, Charles C 2003. Adenosine receptors and mammalian toll-like receptors: synergism in macrophages. Molecular interventions, 3 7, 370-4

Thiel, Manfred; Caldwell, Charles C; Sitkovsky, Michail V 2003. The critical role of adenosine A2A receptors in downregulation of inflammation and immunity in the pathogenesis of infectious diseases. Microbes and infection / Institut Pasteur, 5 6, 515-26

Wen, Long T; Caldwell, Charles C; Knowles, Aileen F 2003. Poly(ADP-ribose) polymerase activation and changes in Bax protein expression associated with extracellular ATP-mediated apoptosis in human embryonic kidney 293-P2X7 cells. Molecular pharmacology, 63 3, 706-13

Kojima, Hidefumi; Gu, Hua; Nomura, Saeko; Caldwell, Charles C; Kobata, Tetsuji; Carmeliet, Peter; Semenza, Gregg L; Sitkovsky, Michail V 2002. Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1alpha -deficient chimeric mice. Proceedings of the National Academy of Sciences of the United States of America, 99 4, 2170-4

Caldwell, C C; Hornyak, S C; Pendleton, E; Campbell, D; Knowles, A F 2001. Regulation of chicken gizzard ecto-ATPase activity by modulators that affect its oligomerization status. Archives of biochemistry and biophysics, 387 1, 107-16

Caldwell, C C; Kojima, H; Lukashev, D; Armstrong, J; Farber, M; Apasov, S G; Sitkovsky, M V 2001. Differential effects of physiologically relevant hypoxic conditions on T lymphocyte development and effector functions. Journal of immunology (Baltimore, Md. : 1950), 167 11, 6140-9

Zhou, P; Freidag, B L; Caldwell, C C; Seder, R A 2001. Perforin is required for primary immunity to Histoplasma capsulatum. Journal of immunology (Baltimore, Md. : 1950), 166 3, 1968-74

Caldwell, C C; Davis, M D; Knowles, A F 1999. Ectonucleotidases of avian gizzard smooth muscle and liver plasma membranes: a comparative study. Archives of biochemistry and biophysics, 362 1, 46-58

Redegeld, F A; Caldwell, C C; Sitkovsky, M V 1999. Ecto-protein kinases: ecto-domain phosphorylation as a novel target for pharmacological manipulation? Trends in pharmacological sciences, 20 11, 453-9

Hurt, R D; Dale, L C; Fredrickson, P A; Caldwell, C C; Lee, G A; Offord, K P; Lauger, G G; Mar?si?, Z; Neese, L W; Lundberg, T G 1994. Nicotine patch therapy for smoking cessation combined with physician advice and nurse follow-up. One-year outcome and percentage of nicotine replacement. JAMA, 271 8, 595-600

Myers, T F; Patrinos, M E; Muraskas, J; Caldwell, C C; Lambert, G H; Anderson, C L 1987. Dynamic trend monitoring of cerebral blood flow velocity in newborn infants. The Journal of pediatrics, 110 4, 611-6

Caldwell, C C; Hurley, R M; Anderson, C L; Ahmed, G S; Myers, T F 1985. Nonimmune hydrops fetalis managed with peritoneal dialysis. American journal of perinatology, 2 3, 211-3

Caldwell, C C; Stankiewicz, J; Anderson, C L; Ahmed, G S; Myers, T F 1985. Intubation-related tracheal stenosis in very-low-birth-weight infants. Diagnosis and treatment. American journal of diseases of children (1960), 139 6, 618-20

Anderson, C L; Collin, M F; O'Keefe, J P; Challapalli, M; Myers, T F; Caldwell, C C; Ahmed, G S 1984. A widespread epidemic of mild necrotizing enterocolitis of unknown cause. American journal of diseases of children (1960), 138 10, 979-83

Puczynski, M S; Dvonch, V M; Menendez, C E; Caldwell, C C 1984. Osteomyelitis of the great toe secondary to phlebotomy. Clinical orthopaedics and related research, 190, 239-40

Caldwell, C C; Levkoff, A H; Purohit, D M 1977. Paroxysmal supraventricular tachycardia in a neonate: a complication of racemic epinephrine inhalation for post-extubation stridor. Clinical pediatrics, 16 6, 579-80

Purohit, D M; Caldwell, C C; Webb, H N; Levkoff, A H 1976. Effects of assisted ventilation on echocardiographic findings in two infants with patent ductus arteriosus. The Journal of thoracic and cardiovascular surgery, 72 2, 294-5

Caldwell C.; Chen P.; Lukashev D.; Ohta A.; Sitkovsky M. 12-28-2001. Differential Regulation of Two Alternatively Spliced Isoforms of Hypoxia-inducible Factor-1? in Acti Journal of Biological Chemistry, 276 52, 48754-48763

Becker K.; Boldrin F.; Caldwell C.; Edwards M.; Goodman M.; Gulbins A.; Gulbins E.; Kleuser B.; Kornhuber J.; Müller C.; Schumacher F.; Soddemann M.; Szabo I.; Wilker B. 12-01-2018. Antidepressants regulate autophagy by targeting acid sphingomyelinase Molecular Psychiatry, 23 12, 2251

Becker K.; Boldrin F.; Caldwell C.; Edwards M.; Goodman M.; Gulbins A.; Gulbins E.; Kleuser B.; Kornhuber J.; Müller C.; Schumacher F.; Soddemann M.; Szabo I.; Wilker B. 12-01-2018. Antidepressants act by inducing autophagy controlled by sphingomyelin–ceramide Molecular Psychiatry, 23 12, 2324-2346

Barra M.; Caldwell C.C.; Hauenschild E.; Hecht L.; Helbig F.; Kalies K.; Kalies K.U.; Klinger M.; Kunz N.; Ludwig R.J.; Maass S.; Soellner S.; Westermann J. 12-01-2017. Nanoparticles prepared from porcine cells support the healing of cutaneous inflammation in mice and Experimental Dermatology, 26 12, 1199-1206

Becker K.; Caldwell C.; Edwards M.; Fraunholz M.; Gulbins E.; Ma J. 12-01-2017. Staphylococcus aureus ?-Toxin Induces Inflammatory Cytokines via Lysosomal Acid Sphingomyelinase and Cellular Physiology and Biochemistry, 43 6, 2170-2184

Caldwell C.; Dahms A.; Davis M.; Stitt O. 12-01-1998. Kinetic differentiation of ecto-aptase sub-families from chicken smooth muscle and liver FASEB Journal, 12 8,

Caldwell C.; Hornyak S.; Stephen Dahms A. 12-01-1998. Probes at the chicken smooth muscle ECTO-ATPASE: A comprehensive regulatory model FASEB Journal, 12 8,

Caldwell C.; Campbell D.; Dahms A.; Gospaderic T. 12-01-1997. Modulation of smooth muscle ecto-atpase activity by lipid covalent/ non-covalent probes FASEB Journal, 11 9,

Baker J.; Boudreau R.; Caldwell C.; Edwards M.; Gulbins E.; Seitz A. 11-01-2018. Sphingolipids and innate immunity: A new approach to infection in the post-antibiotic era? Surgical Infections, 19 8, 792-803

Becker K.; Caldwell C.; Edwards M.; Gulbins E.; Kamler M.; Koch A.; Li X.; Schuchman E.; Seitz A.; Steinmann J. 11-01-2017. Neutrophils Kill Reactive Oxygen Species-Resistant Pseudomonas aeruginosa by Sphingosine Cellular Physiology and Biochemistry, 43 4, 1603-1616

Caldwell C.; Gulbins E.; Nomellini V.; Pugh A.; Rice T.; Seitz A. 11-01-2017. Sphingosine rescues aged mice from pulmonary pseudomonas infection Journal of Surgical Research, 219 , 354-359

Biberthaler P.; Caldwell C.; Ditsch A.; Hanschen M.; Hefele F.; Huber-Wagner S.; Krysiak N.; van Griensven M. 10-11-2019. Trauma Induces Interleukin-17A Expression on Th17 Cells and CD4+ Regulatory T Cells as Well as Plate Frontiers in Immunology, 10 ,

Beckmann N.; Caldwell C.; Pugh A. 10-01-2018. Burn injury alters the intestinal microbiome's taxonomic composition and functional gene expression PLoS ONE, 13 10,

Becker K.; Boudreau R.; Caldwell C.; Couch C.; Edwards M.; Gulbins E.; Martin G.; Seitz A. 10-01-2017. Sphingosine's role in epithelial host defense: A natural antimicrobial and novel therapeutic Biochimie, 141 , 91-96

Caldwell C.; Gulbins E.; Pugh A.; Rice T.; Seitz A.; Whitacre B.; Xia B. 10-01-2017. Bronchoalveolar Lavage Microvesicles Protect Burn-Injured Mice from Pulmonary Infection Journal of the American College of Surgeons, 225 4, 538-547

Caldwell C.; Johnson B.; Kalies K.; Kunz N.; Midura E.; Prakash P.; Rice T. 10-01-2017. Neutrophil derived microparticles increase mortality and the counter-inflammatory response in a muri Biochimica et Biophysica Acta - Molecular Basis of Disease, 1863 10, 2554-2563

Caldwell C.; Dahms A.S.; Jarvis A.; Norman V.; Quinonez C.; Stemm M.; Urbina A. 09-29-1997. Regulatory differences among avian Ecto-ATPases Biochemical and Biophysical Research Communications, 238 3, 728-732

Becker K.; Caldwell C.; Edwards M.; Fraunholz M.; Gulbins E.; Keitsch S.; Riethmüller J.; Sehl C.; Soddemann M.; Wilker B. 09-25-2018. Pulmonary infection of cystic fibrosis mice with Staphylococcus aureus requires expression of ?-Toxi Biological Chemistry, 399 10, 1203-1213

Caldwell C.; Pugh A.; Rice T.; Schneider B. 09-01-2017. Balance Between the Proinflammatory and Anti-Inflammatory Immune Responses with Blood Transfusion in Critical Care Nursing Clinics of North America, 29 3, 331-340

Caldwell C.C.; Gemoll T.; Habermann J.K.; Kalies K.; Kalies K.U.; Klinger M.; Kunz N.; Seitz A.P.; Whitacre B.E.; Xia B.T. 09-01-2017. Cell-Derived Nanoparticles are Endogenous Modulators of Sepsis with Therapeutic Potential Shock, 48 3, 346-354

Auteri N.; Caldwell C.; Goetzman H.; Nomellini V.; Pugh A. 08-10-2017. A murine model of persistent inflammation, immune suppression, and catabolism syndrome International Journal of Molecular Sciences, 18 8,

Baker J.; Beck S.; Becker K.; Caldwell C.; Edwards M.; Gobble R.; Gulbins E.; Kamler M.; Kleuser B.; Schumacher F.; Seitz A.; Soddemann M.; Wilker B. 08-01-2019. Sphingosine-coating of plastic surfaces prevents ventilator-associated pneumonia Journal of Molecular Medicine, 97 8, 1195-1211

Becker K.; Boudreau R.; Brodlie M.; Caldwell C.; Edwards M.; Gardner A.; Grassmé H.; Gulbins E.; Kamler M.; Kleuser B.; Riethmüller J.; Schuchman E.; Seitz A. 08-01-2018. Sphingolipids as targets for inhalation treatment of cystic fibrosis Advanced Drug Delivery Reviews, 133 , 66-75

Boudreau R.M.; Caldwell C.C.; Friend L.A.; Goetzman H.; Goodman M.D.; Johnson M.; Makley A.T.; Veile R. 07-01-2017. Impact of tranexamic acid on coagulation and inflammation in murine models of traumatic brain injury Journal of Surgical Research, 215 , 47-54

Becker K.; Brodlie M.; Caldwell C.; Edwards M.; Gardner A.; Grassmé H.; Gulbins E.; Henry B.; Kamler M.; Lang S.; Riethmüller J.; Schuchman E.; Seitz A.; Steinmann J.; Ward C.; Ziobro R. 06-14-2017. ?1-Integrin Accumulates in Cystic Fibrosis Luminal Airway Epithelial Membranes and Decreases Sphingo Cell Host and Microbe, 21 6, 707-718.e8

Apasov S.; Caldwell C.; Kojima H.; Koshiba M.; Lukashev D.; Ohta A.; Sitkovsky M.; Thiel M. 06-07-2004. Physiological control of immune response and inflammatory tissue damage by hypoxia-inducible factors Annual Review of Immunology, 22 , 657-682

Bittmann I.; Caldwell C.; Chouker A.; Jackson E.; Lukashev D.; Ohta A.; Sitkovsky M.; Smith P.; Thiel M. 06-01-2005. Oxygenation inhibits the physiological tissue-protecting mechanism and thereby exacerbates acute inf PLoS Biology, 3 6, 1088-1100

Beckmann N.; Caldwell C.; Goodman M.; Nomellini V.; Veile R.; Winer L. 05-01-2019. Consumptive coagulopathy is associated with organ dysfunction during PICS American Journal of Physiology - Lung Cellular and Molecular Physiology, 316 5, L946-L952

Caldwell C.; Crouser E.; Hotchkiss R. 05-01-2019. What Is the Skinny on Obesity during Sepsis? Critical Care Medicine, 47 5, 735-736

Caldwell C.; Friend L.; Goodman M.; Makley A.; Martin G.; Moran R.; Pritts T.; Pugh A.; Veile R. 04-01-2019. Microvesicles generated following traumatic brain injury induce platelet dysfunction via adenosine d Journal of Trauma and Acute Care Surgery, 86 4, 592-599

Caldwell C.; Deng S.; Essandoh K.; Fan G.; Huang W.; Li Y.; Mu X.; Peng J.; Peng T.; Pugh A.; Wang R.; Wang X.; Wang Y.; Yu K. 04-01-2018. Circulating Exosomes Isolated from Septic Mice Induce Cardiovascular Hyperpermeability Through Promo Shock, 49 4, 429-441

Caldwell C.C.; Goetzman H.S.; Konishi T.; Lentsch A.B.; Schuster R.M. 03-01-2020. Fibrotic liver has prompt recovery after ischemia-reperfusion injury American journal of physiology. Gastrointestinal and liver physiology, 318 3, G390-G400

Beckmann N.; Caldwell C.; Goetzman H.; Goodman M.; Gulbins E.; Kim Y.; Nomellini V.; Veile R.; Winer L.; Xia B. 03-01-2019. Amitriptyline Treatment Mitigates Sepsis-Induced Tumor Necrosis Factor Expression and Coagulopathy Shock, 51 3, 356-363

Abplanalp W.; Caldwell C.; Gulbins E.; Jung A.; Kim Y.; Lentsch A.; Pritts T.; Schuster R. 03-01-2018. Endocytosis of red blood cell microparticles by pulmonary endothelial cells is mediated by Rab5 Shock, 49 3, 288-294

Armocida S.; Caldwell C.; Gulbins E.; Healy D.; Hildeman D.; Jain A.; Kuethe J.; Midura E.; Rice T. 03-01-2017. Burn injury influences the T cell homeostasis in a butyrate-acid sphingomyelinase dependent manner Cellular Immunology, 313 , 25-31

Apasov S.; Armstrong J.M.; Caldwell C.; Chen J.F.; Chen P.; Figler H.; Fink S.; Linden J.; Schwarzschild M.A.; Sitkovsky M.; Smith P.T.; Sullivan G. 02-15-2001. Gene dose effect reveals G<inf>S</inf>-coupled A<inf>2A</inf> adenosine rece Biochemical Journal, 354 1, 123-130

Abplanalp W.; Caldwell C.; Chang A.; Goodman M.; Jung A.; Kim Y.; Pritts T.; Xia B. 02-01-2018. Microparticles from stored red blood cells promote a hypercoagulable state in a murine model of tran Surgery (United States), 163 2, 423-429

Abplanalp W.; Caldwell C.; Goodman M.; Jung A.; Kim Y.; Lentsch A.; Pritts T.; Schuster R. 01-01-2020. Microparticles from aged packed red blood cell units stimulate pulmonary microthrombus formation via Thrombosis Research, 185 , 160-166

Beckmann N.; Caldwell C.; Gulbins E.; Nomellini V.; Pritts T.; Pugh A.; Winer L.; Xia B. 01-01-2019. Amitriptyline reduces inflammation and mortality in a murine model of sepsis Cellular Physiology and Biochemistry, 52 3, 565-579

Caldwell C.; Goetzman H.; Konishi T.; Lentsch A.; Schuster R. 01-01-2019. Cell-specific regulatory effects of CXCR2 on cholestatic liver injury American Journal of Physiology - Gastrointestinal and Liver Physiology, 317 6, G773-G783

Becker K.; Caldwell C.; Edwards M.; Fahsel B.; Fraunholz M.; Grassmé H.; Gulbins E.; Keitsch S.; Kemper H.; Kohnen M.; Li C.; Mayeres J.; Sehl C.; Seitz A.; Soddemann M.; Wilker B. 01-01-2018. Staphylococcus aureus alpha-toxin disrupts endothelial-cell tight junctions via acid sphingomyelinas Infection and Immunity, 86 1,

Caldwell C.; Friend L.; Goodman M.; Johnson M.; Kim Y.; Makley A.; Martin G.; Veile R.; Xia B. 01-01-2018. Platelet function changes in a time-dependent manner following traumatic brain injury in a murine mo Shock, 50 5, 551-556

Caldwell C.; Kaplan L.; Nomellini V.; Sims C. 01-01-2018. Chronic Critical Illness and Persistent Inflammation: What can we Learn from the Elderly, Injured, S Shock, 49 1, 4-14

Caldwell C.; Chang A.; Edwards M.; Gulbins E.; Hoehn R.; Japtok L.; Jernigan P.; Kleuser B.; Lentsch A.; Midura E.; Pritts T. 01-01-2017. Acid sphingomyelinase inhibition in stored erythrocytes reduces transfusion-associated lung inflamma Annals of Surgery, 265 1, 218-226

Becker K.; Biedermann T.; Bormann T.; Caldwell C.; Döring G.; Edwards M.; Effinger F.; Gebhardt M.; Gulbins E.; Karlsson M.; Leadbetter E.; Müller-Hermelink E.; Siegmann N.; Tighe M.; Ulrich M.; Wermeling F.; Worbs D. 01-01-2014. Invariant natural killer T (iNKT) cells prevent autoimmunity, but induce pulmonary inflammation in c Cellular Physiology and Biochemistry, 34 1, 56-70

Burkovskiy I.; Caldwell C.; Kelly M.; Kuethe J.; Lehmann C.; Zhou J. 01-01-2014. Inhibition of the cannabinoid 2 receptor in CNS-injury induced immunodeficiency syndrome Medical Hypotheses, 82 6, 736-739

Borchers M.; Caldwell C.; Chen Y.; Goetzmann H.; Hao Y.; Hassett D.; Lau G.; Mavrodi D.; Thomashow L.; Young L. 01-01-2009. Pseudomonas aeruginosa exotoxin pyocyanin causes cystic fibrosis airway pathogenesis American Journal of Pathology, 175 6, 2473-2488

Caldwell C.; Fekete C.; Klein M.; Liposits Z.; Nogueiras R.; Reizes O.; Rohner-Jeanrenaud F.; Suchanek P.; Tschöp J.; Tschöp M.; Veyrat-Durebex C.; Watanabe M.; Wittmann G.; Woods S. 01-01-2008. Peripheral, but Not Central, CB1 antagonism provides food intake-independent metabolic benefits in d Diabetes, 57 11, 2977-2991

Bezerra J.; Caldwell C.; Chougnet C.; McNeal M.; Mohanty S.; Sabla G.; Shivakumar P.; Stringer K.; Ward R. 01-01-2007. Effector Role of Neonatal Hepatic CD8<sup>+</sup> Lymphocytes in Epithelial Injury and A Gastroenterology, 133 1, 268-277

Kuethe, Joshua W; Mintz-Cole, Rachael; Johnson, Bobby L; Midura, Emily F; Caldwell, Charles C; Schneider, Barbara St Pierre . Assessing the immune status of critically ill trauma patients by flow cytometry. Nursing research, 63 6, 426-34