Education/CredentialsGeneral Surgery Residency: University of CincinnatiResearch Fellowship: University of CincinnatiMedical Degree: Rush Medical College Bachelor's Degree: Vanderbilt University Contact Information Veterans Admin Med Ctr Office 513-861-3100 Email willia3@ucmail.uc.edu Research InterestsCritical Care, Advanced Laparoscopy Peer Reviewed Publications Fischer, D R; Sun, X; Williams, A B; Gang, G; Pritts, T A; James, J H; Molloy, M; Fischer, J E; Paul, R J; Hasselgren, P O 2001. Dantrolene reduces serum TNFalpha and corticosterone levels and muscle calcium, calpain gene expression, and protein breakdown in septic rats. Shock (Augusta, Ga.), 15 3, 200-7Hobler, S C; Wang, J J; Williams, A B; Melandri, F; Sun, X; Fischer, J E; Hasselgren, P O 1999. Sepsis is associated with increased ubiquitinconjugating enzyme E214k mRNA in skeletal muscle. The American journal of physiology, 276 2 Pt 2, R468-73Williams, A B; Decourten-Myers, G M; Fischer, J E; Luo, G; Sun, X; Hasselgren, P O 1999. Sepsis stimulates release of myofilaments in skeletal muscle by a calcium-dependent mechanism. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 13 11, 1435-43Hobler, S C; Williams, A B; Fischer, J E; Hasselgren, P O 1998. IGF-I stimulates protein synthesis but does not inhibit protein breakdown in muscle from septic rats. The American journal of physiology, 274 2 Pt 2, R571-6Williams, A B; Luchette, F A; Papaconstantinou, H T; Lim, E; Hurst, J M; Johannigman, J A; Davis, K 1997. The effect of early versus late fasciotomy in the management of extremity trauma. Surgery, 122 4, 861-6Williams A.;Wang J.J.;Wang L.I.;Sun X.;Fischer J.E.;Hasselgren P.O. 12-01-1998. Sepsis in mice stimulates muscle proteolysis in the absence of IL-6 American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 275 6 44-6, Mammen J.;James L.;Molloy M.;Williams A.;Wray C.;Sussman J. 09-01-2007. The relationship of lymph node dissection and colon cancer survival in the Veterans Affairs Central American Journal of Surgery, 194 3, 349-354Hobler S.C.;Williams A.;Fischer D.;Wang J.J.;Sun X.;Fischer J.E.;Monaco J.J.;Hasselgren P.O. 08-01-1999. Activity and expression of the 20S proteasome are increased in skeletal muscle during sepsis American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 277 2 46-2, Williams A.;Sun X.;Fischer J.;Hasselgren P. 01-01-1999. The expression of genes in the ubiquitin-proteasome proteolytic pathway is increased in skeletal mus Surgery, 126 4, 744-750
Peer Reviewed Publications Fischer, D R; Sun, X; Williams, A B; Gang, G; Pritts, T A; James, J H; Molloy, M; Fischer, J E; Paul, R J; Hasselgren, P O 2001. Dantrolene reduces serum TNFalpha and corticosterone levels and muscle calcium, calpain gene expression, and protein breakdown in septic rats. Shock (Augusta, Ga.), 15 3, 200-7Hobler, S C; Wang, J J; Williams, A B; Melandri, F; Sun, X; Fischer, J E; Hasselgren, P O 1999. Sepsis is associated with increased ubiquitinconjugating enzyme E214k mRNA in skeletal muscle. The American journal of physiology, 276 2 Pt 2, R468-73Williams, A B; Decourten-Myers, G M; Fischer, J E; Luo, G; Sun, X; Hasselgren, P O 1999. Sepsis stimulates release of myofilaments in skeletal muscle by a calcium-dependent mechanism. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 13 11, 1435-43Hobler, S C; Williams, A B; Fischer, J E; Hasselgren, P O 1998. IGF-I stimulates protein synthesis but does not inhibit protein breakdown in muscle from septic rats. The American journal of physiology, 274 2 Pt 2, R571-6Williams, A B; Luchette, F A; Papaconstantinou, H T; Lim, E; Hurst, J M; Johannigman, J A; Davis, K 1997. The effect of early versus late fasciotomy in the management of extremity trauma. Surgery, 122 4, 861-6Williams A.;Wang J.J.;Wang L.I.;Sun X.;Fischer J.E.;Hasselgren P.O. 12-01-1998. Sepsis in mice stimulates muscle proteolysis in the absence of IL-6 American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 275 6 44-6, Mammen J.;James L.;Molloy M.;Williams A.;Wray C.;Sussman J. 09-01-2007. The relationship of lymph node dissection and colon cancer survival in the Veterans Affairs Central American Journal of Surgery, 194 3, 349-354Hobler S.C.;Williams A.;Fischer D.;Wang J.J.;Sun X.;Fischer J.E.;Monaco J.J.;Hasselgren P.O. 08-01-1999. Activity and expression of the 20S proteasome are increased in skeletal muscle during sepsis American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 277 2 46-2, Williams A.;Sun X.;Fischer J.;Hasselgren P. 01-01-1999. The expression of genes in the ubiquitin-proteasome proteolytic pathway is increased in skeletal mus Surgery, 126 4, 744-750
Fischer, D R; Sun, X; Williams, A B; Gang, G; Pritts, T A; James, J H; Molloy, M; Fischer, J E; Paul, R J; Hasselgren, P O 2001. Dantrolene reduces serum TNFalpha and corticosterone levels and muscle calcium, calpain gene expression, and protein breakdown in septic rats. Shock (Augusta, Ga.), 15 3, 200-7Hobler, S C; Wang, J J; Williams, A B; Melandri, F; Sun, X; Fischer, J E; Hasselgren, P O 1999. Sepsis is associated with increased ubiquitinconjugating enzyme E214k mRNA in skeletal muscle. The American journal of physiology, 276 2 Pt 2, R468-73Williams, A B; Decourten-Myers, G M; Fischer, J E; Luo, G; Sun, X; Hasselgren, P O 1999. Sepsis stimulates release of myofilaments in skeletal muscle by a calcium-dependent mechanism. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 13 11, 1435-43Hobler, S C; Williams, A B; Fischer, J E; Hasselgren, P O 1998. IGF-I stimulates protein synthesis but does not inhibit protein breakdown in muscle from septic rats. The American journal of physiology, 274 2 Pt 2, R571-6Williams, A B; Luchette, F A; Papaconstantinou, H T; Lim, E; Hurst, J M; Johannigman, J A; Davis, K 1997. The effect of early versus late fasciotomy in the management of extremity trauma. Surgery, 122 4, 861-6Williams A.;Wang J.J.;Wang L.I.;Sun X.;Fischer J.E.;Hasselgren P.O. 12-01-1998. Sepsis in mice stimulates muscle proteolysis in the absence of IL-6 American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 275 6 44-6, Mammen J.;James L.;Molloy M.;Williams A.;Wray C.;Sussman J. 09-01-2007. The relationship of lymph node dissection and colon cancer survival in the Veterans Affairs Central American Journal of Surgery, 194 3, 349-354Hobler S.C.;Williams A.;Fischer D.;Wang J.J.;Sun X.;Fischer J.E.;Monaco J.J.;Hasselgren P.O. 08-01-1999. Activity and expression of the 20S proteasome are increased in skeletal muscle during sepsis American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 277 2 46-2, Williams A.;Sun X.;Fischer J.;Hasselgren P. 01-01-1999. The expression of genes in the ubiquitin-proteasome proteolytic pathway is increased in skeletal mus Surgery, 126 4, 744-750