Today is

Department of

Psychiatry and Behavioral Neuroscience

Photo of  Robert McNamara, PhD

Robert McNamara, PhD

Professor of Psychiatry and Neuroscience Director, Lipidomics Research Program

Education/Credentials
  • Doctoral Degree: University of Victoria
  • Post-Doctoral Training: Northwestern University and University of Florida

Contact Information
  • UC Department of Psychiatry and Behavioral Neuroscience
  • PO Box 670559
  • Cincinnati, Ohio 45267-0559
  • Office (513) 558-5601

Peer Reviewed Publications

Display All

McNamara, Robert K; Almeida, Daniel M 2019. Omega-3 Polyunsaturated Fatty Acid Deficiency and Progressive Neuropathology in Psychiatric Disorders: A Review of Translational Evidence and Candidate Mechanisms. Harvard review of psychiatry, ,

Luft, Marissa J; Lamy, Martine; DelBello, Melissa P; McNamara, Robert K; Strawn, Jeffrey R 2018. Antidepressant-Induced Activation in Children and Adolescents: Risk, Recognition and Management. Current problems in pediatric and adolescent health care, 48 2, 50-62

McNamara, Robert K; Kalt, Wilhelmina; Shidler, Marcelle D; McDonald, Jane; Summer, Suzanne S; Stein, Amanda L; Stover, Amanda N; Krikorian, Robert 2018. Cognitive response to fish oil, blueberry, and combined supplementation in older adults with subjective cognitive impairment. Neurobiology of aging, 64 , 147-156

McNamara, Robert K; Schurdak, Jennifer D; Asch, Ruth H; Peters, Bart D; Lindquist, Diana M 2018. Deficits in Docosahexaenoic Acid Accrual during Adolescence Reduce Rat Forebrain White Matter Microstructural Integrity: An in vivo Diffusion Tensor Imaging Study. Developmental neuroscience, 40 1, 84-92

Paterson, Janis; Medvedev, Oleg N; Sumich, Alexander; Tautolo, El-Shadan; Krägeloh, Christian U; Sisk, Rose; McNamara, Robert K; Berk, Michael; Narayanan, Ajit; Siegert, Richard J 2018. Distinguishing transient versus stable aspects of depression in New Zealand Pacific Island children using Generalizability Theory. Journal of affective disorders, 227 , 698-704

Peng, Jiangtong; Li, Yutian; Wang, Xiaohong; Deng, Shan; Holland, Jenna; Yates, Emily; Chen, Jing; Gu, Haitao; Essandoh, Kobina; Mu, Xingjiang; Wang, Boyu; McNamara, Robert K; Peng, Tianqing; Jegga, Anil G; Liu, Tiemin; Nakamura, Takahisa; Huang, Kai; Perez-Tilve, Diego; Fan, Guo-Chang 2018. An Hsp20-FBXO4 Axis Regulates Adipocyte Function through Modulating PPAR? Ubiquitination. Cell reports, 23 12, 3607-3620

Robinson, Delbert G; Gallego, Juan A; John, Majnu; Hanna, Lauren A; Zhang, Jian-Ping; Birnbaum, Michael L; Greenberg, Jessica; Naraine, Melissa; Peters, Bart D; McNamara, Robert K; Malhotra, Anil K; Szeszko, Philip R 2018. A potential role for adjunctive omega-3 polyunsaturated fatty acids for depression and anxiety symptoms in recent onset psychosis: Results from a 16?week randomized placebo-controlled trial for participants concurrently treated with risperidone. Schizophrenia research, ,

Wulsin, Lawson R; Blom, Thomas J; Durling, Michelle; Welge, Jeffrey A; DelBello, Melissa P; Adler, Caleb M; McNamara, Robert K; Strakowski, Stephen M 2018. Cardiometabolic risks and omega-3 index in recent-onset bipolar I disorder. Bipolar disorders, 20 7, 658-665

Almeida, Daniel M; Jandacek, Ronald J; Weber, Wade A; McNamara, Robert K 2017. Docosahexaenoic acid biostatus is associated with event-related functional connectivity in cortical attention networks of typically developing children. Nutritional neuroscience, 20 4, 246-254

Lindquist, Diana M; Asch, Ruth H; Schurdak, Jennifer D; McNamara, Robert K 2017. Effects of dietary-induced alterations in rat brain docosahexaenoic acid accrual on phospholipid metabolism and mitochondrial bioenergetics: An in vivo31P MRS study. Journal of psychiatric research, 95 , 143-146

McNamara, Robert K; Asch, Ruth H; Lindquist, Diana M; Krikorian, Robert 2017. Role of polyunsaturated fatty acids in human brain structure and function across the lifespan: An update on neuroimaging findings. Prostaglandins, leukotrienes, and essential fatty acids, ,

McNamara, Robert K; Asch, Ruth H; Schurdak, Jennifer D; Lindquist, Diana M 2017. Glutamate homeostasis in the adult rat prefrontal cortex is altered by cortical docosahexaenoic acid accrual during adolescence: An in vivo1H MRS study. Psychiatry research. Neuroimaging, 270 , 39-45

McNamara, Robert K; Schurdak, Jennifer D; Asch, Ruth H; Lindquist, Diana M 2017. Omega-3 fatty acid deficiency impairs frontostriatal recruitment following repeated amphetamine treatment in rats: A 7 Tesla in vivo phMRI study. Nutritional neuroscience, , 1-9

McNamara, Robert K; Szeszko, Philip R; Smesny, Stefan; Ikuta, Toshikazu; DeRosse, Pamela; Vaz, Frédéric M; Milleit, Berko; Hipler, Uta-Christina; Wiegand, Cornelia; Hesse, Jana; Amminger, G Paul; Malhotra, Anil K; Peters, Bart D 2017. Polyunsaturated fatty acid biostatus, phospholipase A2 activity and brain white matter microstructure across adolescence. Neuroscience, 343 , 423-433

Messamore, Erik; Almeida, Daniel M; Jandacek, Ronald J; McNamara, Robert K 2017. Polyunsaturated fatty acids and recurrent mood disorders: Phenomenology, mechanisms, and clinical application. Progress in lipid research, 66 , 1-13

Boespflug, E L; McNamara, R K; Eliassen, J C; Schidler, M D; Krikorian, R 2016. Fish Oil Supplementation Increases Event-Related Posterior Cingulate Activation in Older Adults with Subjective Memory Impairment. The journal of nutrition, health & aging, 20 2, 161-9

Lavoie, Suzie; Whitford, Thomas J; Benninger, Franz; Feucht, Martha; Kim, Sung-Wan; Klier, Claudia M; McNamara, Robert K; Rice, Simon; Schäfer, Miriam R; Amminger, G Paul 2016. Correlates of electroencephalographic resting states and erythrocyte membrane docosahexaenoic and eicosapentaenoic acid levels in individuals at ultra-high risk of psychosis. The Australian and New Zealand journal of psychiatry, 50 1, 56-63

Lotrich, Francis E; Sears, Barry; McNamara, Robert K 2016. Polyunsaturated fatty acids moderate the effect of poor sleep on depression risk. Prostaglandins, leukotrienes, and essential fatty acids, 106 , 19-25

McNamara, Robert K 2016. Role of Omega-3 Fatty Acids in the Etiology, Treatment, and Prevention of Depression: Current Status and Future Directions. Journal of nutrition & intermediary metabolism, 5 , 96-106

McNamara, Robert K; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Chu, Wen-Jang; Weber, Wade A; Welge, Jeffrey A; Strawn, Jeffrey R; Adler, Caleb M; DelBello, Melissa P 2016. Effects of fish oil supplementation on prefrontal metabolite concentrations in adolescents with major depressive disorder: a preliminary 1H MRS study. Nutritional neuroscience, 19 4, 145-55

McNamara, Robert K; Jandacek, Ronald; Tso, Patrick; Blom, Thomas J; Welge, Jeffrey A; Strawn, Jeffrey R; Adler, Caleb M; Strakowski, Stephen M; DelBello, Melissa P 2016. Adolescents with or at ultra-high risk for bipolar disorder exhibit erythrocyte docosahexaenoic acid and eicosapentaenoic acid deficits: a candidate prodromal risk biomarker. Early intervention in psychiatry, 10 3, 203-11

McNamara, Robert K; Moser, Ann B; Jones, Richard I; Jandacek, Ronald; Patino, L Rodrigo; Strawn, Jeffrey R; Strakowski, Stephen M; DelBello, Melissa P 2016. Familial risk for bipolar disorder is not associated with impaired peroxisomal function: Dissociation from docosahexaenoic acid deficits. Psychiatry research, 246 , 803-807

McNamara, Robert K; Welge, Jeffrey A 2016. Meta-analysis of erythrocyte polyunsaturated fatty acid biostatus in bipolar disorder. Bipolar disorders, 18 3, 300-6

Messamore, Erik; McNamara, Robert K 2016. Detection and treatment of omega-3 fatty acid deficiency in psychiatric practice: Rationale and implementation. Lipids in health and disease, 15 , 25

Scola, Gustavo; McNamara, Robert K; Croarkin, Paul E; Leffler, Jarrod M; Cullen, Kathryn R; Geske, Jennifer R; Biernacka, Joanna M; Frye, Mark A; DelBello, Melissa P; Andreazza, Ana C 2016. Lipid peroxidation biomarkers in adolescents with or at high-risk for bipolar disorder. Journal of affective disorders, 192 , 176-83

Welge, Jeffrey A; Saliba, Lawrence J; Strawn, Jeffrey R; Eliassen, James C; Patino, L Rodrigo; Adler, Caleb M; Weber, Wade; Schneider, Marguerite Reid; Barzman, Drew H; Strakowski, Stephen M; DelBello, Melissa P; McNamara, Robert K 2016. Neurofunctional Differences Among Youth With and at Varying Risk for Developing Mania. Journal of the American Academy of Child and Adolescent Psychiatry, 55 11, 980-989

Amminger, G P; Mechelli, A; Rice, S; Kim, S-W; Klier, C M; McNamara, R K; Berk, M; McGorry, P D; Schäfer, M R 2015. Predictors of treatment response in young people at ultra-high risk for psychosis who received long-chain omega-3 fatty acids. Translational psychiatry, 5 , e495

McNamara, Robert K 2015. Mitigation of Inflammation-Induced Mood Dysregulation by Long-Chain Omega-3 Fatty Acids. Journal of the American College of Nutrition, 34 Suppl 1 , 48-55

McNamara, Robert K; Jandacek, Ronald; Tso, Patrick; Blom, Thomas J; Welge, Jeffrey A; Strawn, Jeffrey R; Adler, Caleb M; DelBello, Melissa P; Strakowski, Stephen M 2015. First-episode bipolar disorder is associated with erythrocyte membrane docosahexaenoic acid deficits: Dissociation from clinical response to lithium or quetiapine. Psychiatry research, 230 2, 447-53

McNamara, Robert K; Vannest, Jennifer J; Valentine, Christina J 2015. Role of perinatal long-chain omega-3 fatty acids in cortical circuit maturation: Mechanisms and implications for psychopathology. World journal of psychiatry, 5 1, 15-34

Wehry, Anna M; McNamara, Robert K; Adler, Caleb M; Eliassen, James C; Croarkin, Paul; Cerullo, Michael A; DelBello, Melissa P; Strawn, Jeffrey R 2015. Neurostructural impact of co-occurring anxiety in pediatric patients with major depressive disorder: a voxel-based morphometry study. Journal of affective disorders, 171 , 54-9

Able, Jessica A; Liu, Yanhong; Jandacek, Ronald; Rider, Therese; Tso, Patrick; McNamara, Robert K 2014. Omega-3 fatty acid deficient male rats exhibit abnormal behavioral activation in the forced swim test following chronic fluoxetine treatment: association with altered 5-HT1A and alpha2A adrenergic receptor expression. Journal of psychiatric research, 50 , 42-50

McNamara, Robert K; Rider, Therese; Jandacek, Ronald; Tso, Patrick 2014. Abnormal fatty acid pattern in the superior temporal gyrus distinguishes bipolar disorder from major depression and schizophrenia and resembles multiple sclerosis. Psychiatry research, 215 3, 560-7

McNamara, Robert K; Strimpfel, Jennifer; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Welge, Jeffrey A; Strawn, Jeffrey R; Delbello, Melissa P 2014. Detection and Treatment of Long-Chain Omega-3 Fatty Acid Deficiency in Adolescents with SSRI-Resistant Major Depressive Disorder. PharmaNutrition, 2 2, 38-46

Strawn, Jeffrey R; Adler, Caleb M; McNamara, Robert K; Welge, Jeffrey A; Bitter, Samantha M; Mills, Neil P; Barzman, Drew H; Cerullo, Michael A; Chang, Kiki D; Strakowski, Stephen M; DelBello, Melissa P 2014. Antidepressant tolerability in anxious and depressed youth at high risk for bipolar disorder: a prospective naturalistic treatment study. Bipolar disorders, 16 5, 523-30

Lotrich, Francis E; Sears, Barry; McNamara, Robert K 2013. Anger induced by interferon-alpha is moderated by ratio of arachidonic acid to omega-3 fatty acids. Journal of psychosomatic research, 75 5, 475-83

Lotrich, Francis E; Sears, Barry; McNamara, Robert K 2013. Elevated ratio of arachidonic acid to long-chain omega-3 fatty acids predicts depression development following interferon-alpha treatment: relationship with interleukin-6. Brain, behavior, and immunity, 31 , 48-53

McNamara, Robert K 2013. Long-chain omega-3 fatty acid deficiency in mood disorders: rationale for treatment and prevention. Current drug discovery technologies, 10 3, 233-44

McNamara, Robert K 2013. Deciphering the role of docosahexaenoic acid in brain maturation and pathology with magnetic resonance imaging. Prostaglandins, leukotrienes, and essential fatty acids, 88 1, 33-42

McNamara, Robert K; Able, Jessica A; Liu, Yanhong; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Lipton, Jack W 2013. Omega-3 fatty acid deficiency does not alter the effects of chronic fluoxetine treatment on central serotonin turnover or behavior in the forced swim test in female rats. Pharmacology, biochemistry, and behavior, 114-115 , 1-8

McNamara, Robert K; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Dwivedi, Yogesh; Pandey, Ghanshyam N 2013. Adult medication-free schizophrenic patients exhibit long-chain omega-3 Fatty Acid deficiency: implications for cardiovascular disease risk. Cardiovascular psychiatry and neurology, 2013 , 796462

McNamara, Robert K; Jandacek, Ronald; Tso, Patrick; Dwivedi, Yogesh; Ren, Xinguo; Pandey, Ghanshyam N 2013. Lower docosahexaenoic acid concentrations in the postmortem prefrontal cortex of adult depressed suicide victims compared with controls without cardiovascular disease. Journal of psychiatric research, 47 9, 1187-91

McNamara, Robert K; Jandacek, Ronald; Tso, Patrick; Weber, Wade; Chu, Wen-Jang; Strakowski, Stephen M; Adler, Caleb M; Delbello, Melissa P 2013. Low docosahexaenoic acid status is associated with reduced indices in cortical integrity in the anterior cingulate of healthy male children: a 1H MRS Study. Nutritional neuroscience, 16 4, 183-90

McNamara, Robert K; Strawn, Jeffrey R 2013. Role of Long-Chain Omega-3 Fatty Acids in Psychiatric Practice. PharmaNutrition, 1 2, 41-49

McNamara, Robert K; Lotrich, Francis E 2012. Elevated immune-inflammatory signaling in mood disorders: a new therapeutic target? Expert review of neurotherapeutics, 12 9, 1143-61

McNamara, Robert K; Magrisso, I Jack; Hofacer, Rylon; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Benoit, Stephen C 2012. Omega-3 fatty acid deficiency augments risperidone-induced hepatic steatosis in rats: positive association with stearoyl-CoA desaturase. Pharmacological research, 66 4, 283-91

McNamara, Robert K; Strawn, Jeffrey R; Chang, Kiki D; DelBello, Melissa P 2012. Interventions for youth at high risk for bipolar disorder and schizophrenia. Child and adolescent psychiatric clinics of North America, 21 4, 739-51

Richtand, Neil M; Ahlbrand, Rebecca; Horn, Paul; Tambyraja, Rabindra; Grainger, Molly; Bronson, Stefanie L; McNamara, Robert K 2012. Fluoxetine and aripiprazole treatment following prenatal immune activation exert longstanding effects on rat locomotor response. Physiology & behavior, 106 2, 171-7

Schneider, Marguerite Reid; DelBello, Melissa P; McNamara, Robert K; Strakowski, Stephen M; Adler, Caleb M 2012. Neuroprogression in bipolar disorder. Bipolar disorders, 14 4, 356-74

Hofacer, Rylon; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Magrisso, I Jack; Benoit, Stephen C; McNamara, Robert K 2011. Omega-3 fatty acid deficiency selectively up-regulates delta6-desaturase expression and activity indices in rat liver: prevention by normalization of omega-3 fatty acid status. Nutrition research (New York, N.Y.), 31 9, 715-22

Liu, Yanhong; McNamara, Robert K 2011. Elevated Delta-6 desaturase (FADS2) gene expression in the prefrontal cortex of patients with bipolar disorder. Journal of psychiatric research, 45 2, 269-72

McNamara, Robert K 2011. Omega-3 fatty acid deficiency: a preventable risk factor for schizophrenia? Schizophrenia research, 129 2-3, 215-6

McNamara, Robert K; Jandacek, Ronald 2011. Investigation of postmortem brain polyunsaturated fatty acid composition in psychiatric disorders: limitations, challenges, and future directions. Journal of psychiatric research, 45 1, 44-6

McNamara, Robert K; Jandacek, Ronald; Rider, Therese; Tso, Patrick 2011. Chronic risperidone normalizes elevated pro-inflammatory cytokine and C-reactive protein production in omega-3 fatty acid deficient rats. European journal of pharmacology, 652 1-3, 152-6

McNamara, Robert K; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Cole-Strauss, Allyson; Lipton, Jack W 2011. Atypical antipsychotic medications increase postprandial triglyceride and glucose levels in male rats: relationship with stearoyl-CoA desaturase activity. Schizophrenia research, 129 1, 66-73

McNamara, Robert K; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Cole-Strauss, Allyson; Lipton, Jack W 2011. Differential effects of antipsychotic medications on polyunsaturated fatty acid biosynthesis in rats: Relationship with liver delta6-desaturase expression. Schizophrenia research, 129 1, 57-65

McNamara, Robert K; Liu, Yanhong 2011. Reduced expression of fatty acid biosynthesis genes in the prefrontal cortex of patients with major depressive disorder. Journal of affective disorders, 129 1-3, 359-63

Richtand, Neil M; Ahlbrand, Rebecca; Horn, Paul; Stanford, Kevin; Bronson, Stefanie L; McNamara, Robert K 2011. Effects of risperidone and paliperidone pre-treatment on locomotor response following prenatal immune activation. Journal of psychiatric research, 45 9, 1194-201

McNamara, Robert K 2010. DHA deficiency and prefrontal cortex neuropathology in recurrent affective disorders. The Journal of nutrition, 140 4, 864-8

McNamara, Robert K; Able, Jessica A; Rider, Therese; Tso, Patrick; Jandacek, Ronald 2010. Effect of chronic fluoxetine treatment on male and female rat erythrocyte and prefrontal cortex fatty acid composition. Progress in neuro-psychopharmacology & biological psychiatry, 34 7, 1317-21

McNamara, Robert K; Able, Jessica; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Eliassen, James C; Alfieri, David; Weber, Wade; Jarvis, Kelly; DelBello, Melissa P; Strakowski, Stephen M; Adler, Caleb M 2010. Docosahexaenoic acid supplementation increases prefrontal cortex activation during sustained attention in healthy boys: a placebo-controlled, dose-ranging, functional magnetic resonance imaging study. The American journal of clinical nutrition, 91 4, 1060-7

McNamara, Robert K; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Dwivedi, Yogesh; Pandey, Ghanshyam N 2010. Selective deficits in erythrocyte docosahexaenoic acid composition in adult patients with bipolar disorder and major depressive disorder. Journal of affective disorders, 126 1-2, 303-11

McNamara, Robert K; Nandagopal, Jayasree J; Strakowski, Stephen M; DelBello, Melissa P 2010. Preventative strategies for early-onset bipolar disorder: towards a clinical staging model. CNS drugs, 24 12, 983-96

Richtand, Neil M; Liu, Yanhong; Ahlbrand, Rebecca; Sullivan, Juliana R; Newman, Amy Hauck; McNamara, Robert K 2010. Dopaminergic regulation of dopamine D3 and D3nf receptor mRNA expression. Synapse (New York, N.Y.), 64 8, 634-43

Liu, Yanhong; Jandacek, Ronald; Rider, Therese; Tso, Patrick; McNamara, Robert K 2009. Elevated delta-6 desaturase (FADS2) expression in the postmortem prefrontal cortex of schizophrenic patients: relationship with fatty acid composition. Schizophrenia research, 109 1-3, 113-20

McNamara, Robert K 2009. Membrane omega-3 Fatty Acid deficiency as a preventable risk factor for comorbid coronary heart disease in major depressive disorder. Cardiovascular psychiatry and neurology, 2009 , 362795

McNamara, Robert K; Able, Jessica A; Jandacek, Ronald; Rider, Therese; Tso, Patrick 2009. Chronic risperidone treatment preferentially increases rat erythrocyte and prefrontal cortex omega-3 fatty acid composition: evidence for augmented biosynthesis. Schizophrenia research, 107 2-3, 150-7

McNamara, Robert K; Able, Jessica; Jandacek, Ronald; Rider, Therese; Tso, Patrick 2009. Gender differences in rat erythrocyte and brain docosahexaenoic acid composition: role of ovarian hormones and dietary omega-3 fatty acid composition. Psychoneuroendocrinology, 34 4, 532-9

McNamara, Robert K; Able, Jessica; Jandacek, Ronald; Rider, Therese; Tso, Patrick 2009. Inbred C57BL/6J and DBA/2J mouse strains exhibit constitutive differences in regional brain fatty acid composition. Lipids, 44 1, 1-8

McNamara, Robert K; Able, Jessica; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Lindquist, Diana M 2009. Perinatal n-3 fatty acid deficiency selectively reduces myo-inositol levels in the adult rat PFC: an in vivo (1)H-MRS study. Journal of lipid research, 50 3, 405-11

McNamara, Robert K; Able, Jessica; Liu, Yanhong; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Lipton, Jack W 2009. Omega-3 fatty acid deficiency during perinatal development increases serotonin turnover in the prefrontal cortex and decreases midbrain tryptophan hydroxylase-2 expression in adult female rats: dissociation from estrogenic effects. Journal of psychiatric research, 43 6, 656-63

McNamara, Robert K; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Dwivedi, Yogesh; Roberts, Rosalinda C; Conley, Robert R; Pandey, Ghanshyam N 2009. Fatty acid composition of the postmortem prefrontal cortex of adolescent male and female suicide victims. Prostaglandins, leukotrienes, and essential fatty acids, 80 1, 19-26

McNamara, Robert K; Able, Jessica; Jandacek, Ronald; Rider, Therese; Tso, Patrick 2008. WITHDRAWN: Published in error by the publisher: Constitutive differences in regional brain fatty acid content of inbred C57BL/6J and DBA/2J mouse strains. Journal of lipid research, ,

McNamara, Robert K; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Stanford, Kevin E; Hahn, Chang-Gyu; Richtand, Neil M 2008. Deficits in docosahexaenoic acid and associated elevations in the metabolism of arachidonic acid and saturated fatty acids in the postmortem orbitofrontal cortex of patients with bipolar disorder. Psychiatry research, 160 3, 285-99

McNamara, Robert K; Sullivan, Juliana; Richtand, Neil M 2008. Omega-3 fatty acid deficiency augments amphetamine-induced behavioral sensitization in adult mice: prevention by chronic lithium treatment. Journal of psychiatric research, 42 6, 458-68

McNamara, Robert K; Sullivan, Juliana; Richtand, Neil M; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Campbell, Nick; Lipton, Jack 2008. Omega-3 fatty acid deficiency augments amphetamine-induced behavioral sensitization in adult DBA/2J mice: relationship with ventral striatum dopamine concentrations. Synapse (New York, N.Y.), 62 10, 725-35

Richtand, Neil M; McNamara, Robert K 2008. Serotonin and dopamine interactions in psychosis prevention. Progress in brain research, 172 , 141-53

Richtand, Neil M; Welge, Jeffrey A; Logue, Aaron D; Keck, Paul E; Strakowski, Stephen M; McNamara, Robert K 2008. Role of serotonin and dopamine receptor binding in antipsychotic efficacy. Progress in brain research, 172 , 155-75

McNamara, Robert K; Hahn, Chang-Gyu; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Stanford, Kevin E; Richtand, Neil M 2007. Selective deficits in the omega-3 fatty acid docosahexaenoic acid in the postmortem orbitofrontal cortex of patients with major depressive disorder. Biological psychiatry, 62 1, 17-24

McNamara, Robert K; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Hahn, Chang-Gyu; Richtand, Neil M; Stanford, Kevin E 2007. Abnormalities in the fatty acid composition of the postmortem orbitofrontal cortex of schizophrenic patients: gender differences and partial normalization with antipsychotic medications. Schizophrenia research, 91 1-3, 37-50

Pritchard, Laurel M; Newman, Amy Hauck; McNamara, Robert K; Logue, Aaron D; Taylor, Benjamin; Welge, Jeffrey A; Xu, Ming; Zhang, Jianhua; Richtand, Neil M 2007. The dopamine D3 receptor antagonist NGB 2904 increases spontaneous and amphetamine-stimulated locomotion. Pharmacology, biochemistry, and behavior, 86 4, 718-26

Richtand, Neil M; Welge, Jeffrey A; Logue, Aaron D; Keck, Paul E; Strakowski, Stephen M; McNamara, Robert K 2007. Dopamine and serotonin receptor binding and antipsychotic efficacy. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 32 8, 1715-26

Hussain, Rifat J; Stumpo, Deborah J; Blackshear, Perry J; Lenox, Robert H; Abel, Ted; McNamara, Robert K 2006. Myristoylated alanine rich C kinase substrate (MARCKS) heterozygous mutant mice exhibit deficits in hippocampal mossy fiber-CA3 long-term potentiation. Hippocampus, 16 5, 495-503

McNamara, R K; Levant, B; Taylor, B; Ahlbrand, R; Liu, Y; Sullivan, J R; Stanford, K; Richtand, N M 2006. C57BL/6J mice exhibit reduced dopamine D3 receptor-mediated locomotor-inhibitory function relative to DBA/2J mice. Neuroscience, 143 1, 141-53

McNamara, Robert K; Logue, Aaron; Stanford, Kevin; Xu, Ming; Zhang, Jianhua; Richtand, Neil M 2006. Dose-response analysis of locomotor activity and stereotypy in dopamine D3 receptor mutant mice following acute amphetamine. Synapse (New York, N.Y.), 60 5, 399-405

Richtand, Neil M; Taylor, Benjamin; Welge, Jeffrey A; Ahlbrand, Rebecca; Ostrander, Michelle M; Burr, Jeffrey; Hayes, Scott; Coolen, Lique M; Pritchard, Laurel M; Logue, Aaron; Herman, James P; McNamara, Robert K 2006. Risperidone pretreatment prevents elevated locomotor activity following neonatal hippocampal lesions. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 31 1, 77-89

Delgado, Pedro L; Brannan, Stephen K; Mallinckrodt, Craig H; Tran, Pierre V; McNamara, Robert K; Wang, Fujun; Watkin, John G; Detke, Michael J 2005. Sexual functioning assessed in 4 double-blind placebo- and paroxetine-controlled trials of duloxetine for major depressive disorder. The Journal of clinical psychiatry, 66 6, 686-92

McNamara, Robert K; Hussain, Rifat J; Simon, Erica J; Stumpo, Deborah J; Blackshear, Perry J; Abel, Ted; Lenox, Robert H 2005. Effect of myristoylated alanine-rich C kinase substrate (MARCKS) overexpression on hippocampus-dependent learning and hippocampal synaptic plasticity in MARCKS transgenic mice. Hippocampus, 15 5, 675-83

Detke, Michael J; Wiltse, Curtis G; Mallinckrodt, Craig H; McNamara, Robert K; Demitrack, Mark A; Bitter, Istvan 2004. Duloxetine in the acute and long-term treatment of major depressive disorder: a placebo- and paroxetine-controlled trial. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 14 6, 457-70

Greist, John; McNamara, Robert K; Mallinckrodt, Craig H; Rayamajhi, Jyoti N; Raskin, Joel 2004. Incidence and duration of antidepressant-induced nausea: duloxetine compared with paroxetine and fluoxetine. Clinical therapeutics, 26 9, 1446-55

McNamara, Robert K; Lenox, Robert H 2004. Acute restraint stress reduces protein kinase C gamma in the hippocampus of C57BL/6 but not DBA/2 mice. Neuroscience letters, 368 3, 293-6

Bymaster, Frank P; McNamara, Robert K; Tran, Pierre V 2003. New approaches to developing antidepressants by enhancing monoaminergic neurotransmission. Expert opinion on investigational drugs, 12 4, 531-43

McNamara, Robert K; Vasquez, Patricia A; Mathe, Aleksander A; Lenox, Robert H 2003. Differential expression and regulation of myristoylated alanine-rich C kinase substrate (MARCKS) in the hippocampus of C57/BL6J and DBA/2J mice. Journal of neurochemistry, 85 2, 462-8

Tran, Pierre V; Bymaster, Frank P; McNamara, Robert K; Potter, William Z 2003. Dual monoamine modulation for improved treatment of major depressive disorder. Journal of clinical psychopharmacology, 23 1, 78-86

Huot, Rebecca L; Plotsky, Paul M; Lenox, Robert H; McNamara, Robert K 2002. Neonatal maternal separation reduces hippocampal mossy fiber density in adult Long Evans rats. Brain research, 950 1-2, 52-63

Krucker, Thomas; Siggins, George R; McNamara, Robert K; Lindsley, Kristen A; Dao, Alan; Allison, David W; De Lecea, Luis; Lovenberg, Timothy W; Sutcliffe, J Gregor; Gerendasy, Dan D 2002. Targeted disruption of RC3 reveals a calmodulin-based mechanism for regulating metaplasticity in the hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience, 22 13, 5525-35

McNamara, Robert K; Huot, Rebecca L; Lenox, Robert H; Plotsky, Paul M 2002. Postnatal maternal separation elevates the expression of the postsynaptic protein kinase C substrate RC3, but not presynaptic GAP-43, in the developing rat hippocampus. Developmental neuroscience, 24 6, 485-94

McNamara, R K; Jiang, Y; Streit, W J; Lenox, R H 2000. Facial motor neuron regeneration induces a unique spatial and temporal pattern of myristoylated alanine-rich C kinase substrate expression. Neuroscience, 97 3, 581-9

McNamara, R K; Lenox, R H 2000. Differential regulation of primary protein kinase C substrate (MARCKS, MLP, GAP-43, RC3) mRNAs in the hippocampus during kainic acid-induced seizures and synaptic reorganization. Journal of neuroscience research, 62 3, 416-26

Klein, R L; McNamara, R K; King, M A; Lenox, R H; Muzyczka, N; Meyer, E M 1999. Generation of aberrant sprouting in the adult rat brain by GAP-43 somatic gene transfer. Brain research, 832 1-2, 136-44

McNamara, R K; Hyde, T M; Kleinman, J E; Lenox, R H 1999. Expression of the myristoylated alanine-rich C kinase substrate (MARCKS) and MARCKS-related protein (MRP) in the prefrontal cortex and hippocampus of suicide victims. The Journal of clinical psychiatry, 60 Suppl 2 , 21-6; discussion 40-

McNamara, R K; Wees, E A; Lenox, R H 1999. Differential subcellular redistribution of protein kinase C isozymes in the rat hippocampus induced by kainic acid. Journal of neurochemistry, 72 4, 1735-43

Petitto, J M; McNamara, R K; Gendreau, P L; Huang, Z; Jackson, A J 1999. Impaired learning and memory and altered hippocampal neurodevelopment resulting from interleukin-2 gene deletion. Journal of neuroscience research, 56 4, 441-6

Ramakers, G M; McNamara, R K; Lenox, R H; De Graan, P N 1999. Differential changes in the phosphorylation of the protein kinase C substrates myristoylated alanine-rich C kinase substrate and growth-associated protein-43/B-50 following Schaffer collateral long-term potentiation and long-term depression. Journal of neurochemistry, 73 5, 2175-83

Harrison, J K; Jiang, Y; Chen, S; Xia, Y; Maciejewski, D; McNamara, R K; Streit, W J; Salafranca, M N; Adhikari, S; Thompson, D A; Botti, P; Bacon, K B; Feng, L 1998. Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia. Proceedings of the National Academy of Sciences of the United States of America, 95 18, 10896-901

Lenox, R H; McNamara, R K; Papke, R L; Manji, H K 1998. Neurobiology of lithium: an update. The Journal of clinical psychiatry, 59 Suppl 6 , 37-47

McNamara, R K; Lenox, R H 1998. Distribution of the protein kinase C substrates MARCKS and MRP in the postnatal developing rat brain. The Journal of comparative neurology, 397 3, 337-56

McNamara, R K; Stumpo, D J; Morel, L M; Lewis, M H; Wakeland, E K; Blackshear, P J; Lenox, R H 1998. Effect of reduced myristoylated alanine-rich C kinase substrate expression on hippocampal mossy fiber development and spatial learning in mutant mice: transgenic rescue and interactions with gene background. Proceedings of the National Academy of Sciences of the United States of America, 95 24, 14517-22

McNamara, R K; Lenox, R H 1997. Comparative distribution of myristoylated alanine-rich C kinase substrate (MARCKS) and F1/GAP-43 gene expression in the adult rat brain. The Journal of comparative neurology, 379 1, 48-71

McNamara, R K; Skelton, R W 1997. Tolerance develops to the spatial learning deficit produced by diazepam in rats. Pharmacology, biochemistry, and behavior, 56 3, 383-9

Gilbert, T H; McNamara, R K; Corcoran, M E 1996. Kindling of hippocampal field CA1 impairs spatial learning and retention in the Morris water maze. Behavioural brain research, 82 1, 57-66

Kinney, W R; McNamara, R K; Valcourt, E; Routtenberg, A 1996. Prolonged alteration in E-box binding after a single systemic kainate injection: potential relation to F1/GAP-43 gene expression. Brain research. Molecular brain research, 38 1, 25-36

Lenox, R H; McNamara, R K; Watterson, J M; Watson, D G 1996. Myristoylated alanine-rich C kinase substrate (MARCKS): a molecular target for the therapeutic action of mood stabilizers in the brain? The Journal of clinical psychiatry, 57 Suppl 13 , 23-31; discussion 32

McNamara, R K; Davis, T M; Skelton, R W 1996. Effect of aging on the spatial learning deficit produced by diazepam in rats. Progress in neuro-psychopharmacology & biological psychiatry, 20 5, 873-81

McNamara, R K; Namgung, U; Routtenberg, A 1996. Distinctions between hippocampus of mouse and rat: protein F1/GAP-43 gene expression, promoter activity, and spatial memory. Brain research. Molecular brain research, 40 2, 177-87

McNamara, R K; Skelton, R W 1996. Baclofen, a selective GABAB receptor agonist, dose-dependently impairs spatial learning in rats. Pharmacology, biochemistry, and behavior, 53 2, 303-8

McNamara, R K; Routtenberg, A 1995. NMDA receptor blockade prevents kainate induction of protein F1/GAP-43 mRNA in hippocampal granule cells and subsequent mossy fiber sprouting in the rat. Brain research. Molecular brain research, 33 1, 22-8

McNamara, R K; Corcoran, M E 1993. CL 218,872 a triazolopyridazine with a selective affinity for the benzodiazepine BZ1 receptor subtype, retards the development and expression of amygdaloid-kindled seizures: effects of flumazenil. Epilepsy research, 16 1, 19-26

McNamara, R K; dePape, G E; Skelton, R W 1993. Differential effects of benzodiazepine receptor agonists on hippocampal long-term potentiation and spatial learning in the Morris water maze. Brain research, 626 1-2, 63-70

McNamara, R K; Kirkby, R D; dePape, G E; Skelton, R W; Corcoran, M E 1993. Differential effects of kindling and kindled seizures on place learning in the Morris water maze. Hippocampus, 3 2, 149-52

McNamara, R K; Skeleton, R W 1993. Effects of intracranial infusions of chlordiazepoxide on spatial learning in the Morris water maze. I. Neuroanatomical specificity. Behavioural brain research, 59 1-2, 175-91

McNamara, R K; Skelton, R W 1993. Effects of intracranial infusions of chlordiazepoxide on spatial learning in the Morris water maze. II. Neuropharmacological specificity. Behavioural brain research, 59 1-2, 193-204

McNamara, R K; Kirkby, R D; dePape, G E; Corcoran, M E 1992. Limbic seizures, but not kindling, reversibly impair place learning in the Morris water maze. Behavioural brain research, 50 1-2, 167-75

McNamara, R K; Skelton, R W 1992. Assessment of a cholinergic contribution to chlordiazepoxide-induced deficits of place learning in the Morris water maze. Pharmacology, biochemistry, and behavior, 41 3, 529-38

McNamara, R K; Skelton, R W 1992. Pharmacological dissociation between the spatial learning deficits produced by morphine and diazepam. Psychopharmacology, 108 1-2, 147-52

McNamara, R K; Skelton, R W 1992. Like diazepam, CL 218,872, a selective ligand for the benzodiazepine omega 1 receptor subtype, impairs place learning in the Morris water maze. Psychopharmacology, 107 2-3, 347-51

Skelton, R W; McNamara, R K 1992. Bilateral knife cuts to the perforant path disrupt spatial learning in the Morris water maze. Hippocampus, 2 1, 73-80

McNamara, R K; Skelton, R W 1991. Diazepam impairs acquisition but not performance in the Morris water maze. Pharmacology, biochemistry, and behavior, 38 3, 651-8

McNamara, R K; Whishaw, I Q 1990. Blockade of hoarding in rats by diazepam: an analysis of the anxiety and object value hypotheses of hoarding. Psychopharmacology, 101 2, 214-21

Whishaw, I Q; Oddie, S D; McNamara, R K; Harris, T L; Perry, B S 1990. Psychophysical methods for study of sensory-motor behavior using a food-carrying (hoarding) task in rodents. Journal of neuroscience methods, 32 2, 123-33

Asch R.; Lindquist D.; McNamara R.; Schurdak J. 12-30-2017. Omega-3 fatty acid deficiency impairs frontostriatal recruitment following repeated amphetamine trea Nutritional Neuroscience, , 1-9

McNamara R. 12-20-2012. Depressive disorders and inflammation Nutrition and Physical Activity in Inflammatory Diseases, , 273-298

McNamara R. 12-04-2015. Role of dietary fatty acids in mood disorders Handbook of Lipids in Human Function: Fatty Acids, , 423-456

McNamara R. 12-01-2009. Modulation of polyunsaturated fatty acid biosynthesis by antipsychotic medications: Implications for Clinical Lipidology, 4 6, 809-820

Chen G.; Lenox R.; Manji H.; McNamara R. 12-01-1999. Signalling pathways in the brain: Cellular transduction of mood stabilisation in the treatment of ma Australian and New Zealand Journal of Psychiatry, 33 SUPPL.,

Abonia P.; Adler C.; Barzman D.; DelBello M.; Durling M.; Eliassen J.; Lin P.; McNamara R.; Mossman D. 11-30-2014. Correlations of inflammatory gene pathways, corticolimbic functional activities, and aggression in p Psychiatry Research - Neuroimaging, 224 2, 107-111

McNamara R. 09-01-2016. Role of Omega-3 fatty acids in the etiology, treatment, and prevention of depression: Current status Journal of Nutrition and Intermediary Metabolism, 5 , 96-106

McNamara R. 05-01-2013. Developmental long-chain omega-3 fatty acid deficiency and prefrontal cortex pathology in psychiatri Prefrontal Cortex: Developmental Differences, Executive and Cognitive Functions and Role in Neurological Disorders, , 1-38

Dwivedi Y.; Jandacek R.; McNamara R.; Pandey G.; Rider T.; Tso P. 04-03-2013. Adult medication-free schizophrenic patients exhibit long-chain omega-3 fatty acid deficiency: Impli Cardiovascular Psychiatry and Neurology, 2013 ,

McNamara R.; Strawn J. 04-01-2013. Role of long-chain omega-3 fatty acids in psychiatric practice PharmaNutrition, 1 2, 41-49

McNamara R. 03-01-2013. The omega-3 fatty acid deficiency syndrome: Opportunities for disease prevention The Omega-3 Fatty Acid Deficiency Syndrome: Opportunities for Disease Prevention, , 1-445

McNamara R. 03-01-2013. The Omega-3 Deficiency Syndrome The Omega-3 Fatty Acid Deficiency Syndrome: Opportunities for Disease Prevention, ,

Mcnamara R. 01-01-2015. Dietary fats and mood disorders - translating research into practice Lipid Technology, 27 11, 251-254

McNamara R.; Valentine C. 01-01-2015. Role of long-chain omega-3 fatty acids in cognitive and emotional development Nutrition for Brain Health and Cognitive Performance, , 151-187

DelBello M.; Jandacek R.; McNamara R.; Rider T.; Strawn J.; Strimpfel J.; Tso P.; Welge J. 01-01-2014. Detection and treatment of long-chain omega-3 fatty acid deficiency in adolescents with SSRI-resista PharmaNutrition, 2 2, 38-46

Adler C.; Chu W.; Delbello M.; Jandacek R.; McNamara R.; Strakowski S.; Tso P.; Weber W. 01-01-2013. Low docosahexaenoic acid status is associated with reduced indices in cortical integrity in the ante Nutritional Neuroscience, 16 4, 183-190

Dwivedi Y.; Jandacek R.; McNamara R.; Pandey G.; Ren X.; Tso P. 01-01-2013. Lower docosahexaenoic acid concentrations in the postmortem prefrontal cortex of adult depressed sui Journal of Psychiatric Research, 47 9, 1187-1191

Lenox R.; McNamara R. 01-01-2004. The myristoylated alanine-rich C kinase substrate: A lithium-regulated protein linking cellular sign Clinical Neuroscience Research, 4 3-4 SPEC. ISS., 155-169

McNamara R.; Skelton R. 01-01-1993. Benzodiazepine receptor antagonists flumazenil and CGS 8216 and inverse-agonist ?-CCM nhance spatial Psychobiology, 21 2, 101-108

McNamara R.; Skelton R. 01-01-1991. Pretraining morphine impairs acquisition and performance in the Morris water maze: Motivation reduct Psychobiology, 19 4, 313-322

. http://www.ncbi.nlm.nih.gov/pubmed?term=mcnamara%20rk , ,

Detke, Michael J; Lu, Yili; Goldstein, David J; McNamara, Robert K; Demitrack, Mark A . Duloxetine 60 mg once daily dosing versus placebo in the acute treatment of major depression. Journal of psychiatric research, 36 6, 383-90

Hofacer, Rylon; Magrisso, I Jack; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Benoit, Stephen C; McNamara, Robert K . Omega-3 fatty acid deficiency increases stearoyl-CoA desaturase expression and activity indices in rat liver: positive association with non-fasting plasma triglyceride levels. Prostaglandins, leukotrienes, and essential fatty acids, 86 1-2, 71-7

McNamara, R K; Skelton, R W . The neuropharmacological and neurochemical basis of place learning in the Morris water maze. Brain research. Brain research reviews, 18 1, 33-49

McNamara, Robert K . Evaluation of docosahexaenoic acid deficiency as a preventable risk factor for recurrent affective disorders: current status, future directions, and dietary recommendations. Prostaglandins, leukotrienes, and essential fatty acids, 81 2-3, 223-31

McNamara, Robert K . The emerging role of omega-3 fatty acids in psychiatry. Prostaglandins, leukotrienes, and essential fatty acids, 75 4-5, 223-5

McNamara, Robert K; Carlson, Susan E . Role of omega-3 fatty acids in brain development and function: potential implications for the pathogenesis and prevention of psychopathology. Prostaglandins, leukotrienes, and essential fatty acids, 75 4-5, 329-49

McNamara, Robert K; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Cole-Strauss, Allyson; Lipton, Jack W . Omega-3 fatty acid deficiency increases constitutive pro-inflammatory cytokine production in rats: relationship with central serotonin turnover. Prostaglandins, leukotrienes, and essential fatty acids, 83 4-6, 185-91

McNamara, Robert K; Liu, Yanhong; Jandacek, Ronald; Rider, Therese; Tso, Patrick . The aging human orbitofrontal cortex: decreasing polyunsaturated fatty acid composition and associated increases in lipogenic gene expression and stearoyl-CoA desaturase activity. Prostaglandins, leukotrienes, and essential fatty acids, 78 4-5, 293-304

McNamara, Robert K; Ostrander, Michelle; Abplanalp, William; Richtand, Neil M; Benoit, Stephen C; Clegg, Debbie J . Modulation of phosphoinositide-protein kinase C signal transduction by omega-3 fatty acids: implications for the pathophysiology and treatment of recurrent neuropsychiatric illness. Prostaglandins, leukotrienes, and essential fatty acids, 75 4-5, 237-57