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Department of

Psychiatry and Behavioral Neuroscience

Photo of  Lesley Arnold, MD

Lesley Arnold, MD

Professor of Psychiatry; Director of the Women’s Health Research Program

Education/Credentials
  • Bachelor's Degree: Cornell University
  • Medical Degree: University of Cincinnati College of Medicine
  • Residency: University of Cincinnati College of Medicine

Board Certifications & Licenses
  • American Board of Psychiatry and Neurology (Psychiatry) 01/30/1992
Contact Information
  • Stetson Building
  • Suite 3200
  • 260 Stetson Street
  • Cincinnati, Ohio 45219
  • Office 513-558-7700
  • Email lesley.arnold@uc.edu

Peer Reviewed Publications

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Arnold, Lesley M 2010. The pathophysiology, diagnosis and treatment of fibromyalgia. The Psychiatric clinics of North America, 33 2, 375-408

Arnold, Lesley M; Clauw, Daniel J 2010. Fibromyalgia syndrome: practical strategies for improving diagnosis and patient outcomes. The American journal of medicine, 123 6, S2

Arnold, Lesley M; Clauw, Daniel; Wang, Fujun; Ahl, Jonna; Gaynor, Paula J; Wohlreich, Madelaine M 2010. Flexible Dosed Duloxetine in the Treatment of Fibromyalgia: A Randomized, Double-blind, Placebo-controlled Trial. The Journal of rheumatology, ,

Arnold, Lesley M; Gendreau, R Michael; Palmer, Robert H; Gendreau, Judy F; Wang, Yong 2010. Efficacy and safety of milnacipran 100 mg/day in patients with fibromyalgia: Results of a randomized, double-blind, placebo-controlled trial. Arthritis and rheumatism, ,

Arnold, Lesley; Mease, Philip; Silverman, Stuart 2010. Pregabalin: an alpha2-delta (alpha2-delta) ligand for the management of fibromyalgia. The American journal of managed care, 16 5 Suppl, S138-43

Kashikar-Zuck, Susmita; Flowers, Stacy R; Verkamp, Emily; Ting, Tracy V; Lynch-Jordan, Anne M; Graham, T Brent; Passo, Murray; Schikler, Kenneth N; Hashkes, Philip J; Spalding, Steven; Banez, Gerard; Richards, Margaret M; Powers, Scott W; Arnold, Lesley M; Lovell, Daniel 2010. Actigraphy-based physical activity monitoring in adolescents with juvenile primary fibromyalgia syndrome. The journal of pain : official journal of the American Pain Society, 11 9, 885-93

Kashikar-Zuck, Susmita; Johnston, Megan; Ting, Tracy V; Graham, Brent T; Lynch-Jordan, Anne M; Verkamp, Emily; Passo, Murray; Schikler, Kenneth N; Hashkes, Philip J; Spalding, Steven; Banez, Gerard; Richards, Margaret M; Powers, Scott W; Arnold, Lesley M; Lovell, Daniel 2010. Relationship between School Absenteeism and Depressive Symptoms among Adolescents with Juvenile Fibromyalgia. Journal of pediatric psychology, 35 9, 996-1004

Arnold, Lesley M 2009. Strategies for managing fibromyalgia. The American journal of medicine, 122 12 Suppl, S31-43

Arnold, Lesley M 2009. Advances in the management of fibromyalgia. CNS spectrums, 14 10 Suppl 8, 12-6; discussion 17-

Arnold, Lesley M 2009. Pain and the brain: chronic widespread pain. The Journal of clinical psychiatry, 70 4, e10

Arnold, Lesley M; Clauw, Daniel J; Wohlreich, Madelaine M; Wang, Fujun; Ahl, Jonna; Gaynor, Paula J; Chappell, Amy S 2009. Efficacy of duloxetine in patients with fibromyalgia: pooled analysis of 4 placebo-controlled clinical trials. Primary care companion to the Journal of clinical psychiatry, 11 5, 237-44

Choy, Ernest H; Arnold, Lesley M; Clauw, Daniel J; Crofford, Leslie J; Glass, Jennifer M; Simon, Lee S; Martin, Susan A; Strand, C Vibeke; Williams, David A; Mease, Philip J 2009. Content and criterion validity of the preliminary core dataset for clinical trials in fibromyalgia syndrome. The Journal of rheumatology, 36 10, 2330-4

Hudson, James I; Arnold, Lesley M; Bradley, Laurence A; Choy, Ernest H S; Mease, Philip J; Wang, Fujun; Ahl, Jonna; Wohlreich, Madelaine M 2009. What makes patients with fibromyalgia feel better? Correlations between Patient Global Impression of Improvement and changes in clinical symptoms and function: a pooled analysis of 4 randomized placebo-controlled trials of duloxetine. The Journal of rheumatology, 36 11, 2517-22

Mease, Philip; Arnold, Lesley M; Choy, Ernest H; Clauw, Daniel J; Crofford, Leslie J; Glass, Jennifer M; Martin, Susan A; Morea, Jessica; Simon, Lee; Strand, C Vibeke; Williams, David A 2009. Fibromyalgia syndrome module at OMERACT 9: domain construct. The Journal of rheumatology, 36 10, 2318-29

Arnold, Lesley M 2008. Management of fibromyalgia and comorbid psychiatric disorders. The Journal of clinical psychiatry, 69 Suppl 2 , 14-9

Arnold, Lesley M; Bradley, Laurence A; Clauw, Daniel J; Glass, Jennifer M; Goldenberg, Don L 2008. Multidisciplinary care and stepwise treatment for fibromyalgia. The Journal of clinical psychiatry, 69 12, e35

Arnold, Lesley M; Bradley, Laurence A; Clauw, Daniel J; Glass, Jennifer M; Goldenberg, Don L 2008. Evaluating and diagnosing fibromyalgia and comorbid psychiatric disorders. The Journal of clinical psychiatry, 69 10, e28

Arnold, Lesley M; Crofford, Leslie J; Mease, Philip J; Burgess, Somali Misra; Palmer, Susan C; Abetz, Linda; Martin, Susan A 2008. Patient perspectives on the impact of fibromyalgia. Patient education and counseling, 73 1, 114-20

Arnold, Lesley M; Jain, Rakesh; Glazer, William M 2008. Pain and the brain. The Journal of clinical psychiatry, 69 9, e25

Arnold, Lesley M; Russell, I Jon; Diri, E W; Duan, W Rachel; Young, James P; Sharma, Uma; Martin, Susan A; Barrett, Jeannette A; Haig, George 2008. A 14-week, randomized, double-blinded, placebo-controlled monotherapy trial of pregabalin in patients with fibromyalgia. The journal of pain : official journal of the American Pain Society, 9 9, 792-805

Lawrence, Reva C; Felson, David T; Helmick, Charles G; Arnold, Lesley M; Choi, Hyon; Deyo, Richard A; Gabriel, Sherine; Hirsch, Rosemarie; Hochberg, Marc C; Hunder, Gene G; Jordan, Joanne M; Katz, Jeffrey N; Kremers, Hilal Maradit; Wolfe, Frederick 2008. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. Arthritis and rheumatism, 58 1, 26-35

Mease, Philip J; Russell, I Jon; Arnold, Lesley M; Florian, Hana; Young, James P; Martin, Susan A; Sharma, Uma 2008. A randomized, double-blind, placebo-controlled, phase III trial of pregabalin in the treatment of patients with fibromyalgia. The Journal of rheumatology, 35 3, 502-14

Mease, Phillip J; Arnold, Lesley M; Crofford, Leslie J; Williams, David A; Russell, I Jon; Humphrey, Louise; Abetz, Linda; Martin, Susan A 2008. Identifying the clinical domains of fibromyalgia: contributions from clinician and patient Delphi exercises. Arthritis and rheumatism, 59 7, 952-60

Russell, I Jon; Mease, Philip J; Smith, Timothy R; Kajdasz, Daniel K; Wohlreich, Madelaine M; Detke, Michael J; Walker, Daniel J; Chappell, Amy S; Arnold, Lesley M 2008. Efficacy and safety of duloxetine for treatment of fibromyalgia in patients with or without major depressive disorder: Results from a 6-month, randomized, double-blind, placebo-controlled, fixed-dose trial. Pain, 136 3, 432-44

Arnold, Lesley M 2007. Duloxetine and other antidepressants in the treatment of patients with fibromyalgia. Pain medicine (Malden, Mass.), 8 Suppl 2 , S63-74

Arnold, Lesley M; Goldenberg, Don L; Stanford, Sharon B; Lalonde, Justine K; Sandhu, H S; Keck, Paul E; Welge, Jeffrey A; Bishop, Fred; Stanford, Kevin E; Hess, Evelyn V; Hudson, James I 2007. Gabapentin in the treatment of fibromyalgia: a randomized, double-blind, placebo-controlled, multicenter trial. Arthritis and rheumatism, 56 4, 1336-44

Arnold, Lesley M; Pritchett, Yili Lu; D'Souza, Deborah N; Kajdasz, Daniel K; Iyengar, Smriti; Wernicke, Joachim F 2007. Duloxetine for the treatment of fibromyalgia in women: pooled results from two randomized, placebo-controlled clinical trials. Journal of women's health (2002), 16 8, 1145-56

Mease, Philip; Arnold, Lesley M; Bennett, Robert; Boonen, Annelies; Buskila, Dan; Carville, Serena; Chappell, Amy; Choy, Ernest; Clauw, Daniel; Dadabhoy, Dina; Gendreau, Michael; Goldenberg, Don; Littlejohn, Geoffrey; Martin, Susan; Perera, Philip; Russell, I Jon; Simon, Lee; Spaeth, Michael; Williams, David; Crofford, Leslie 2007. Fibromyalgia syndrome. The Journal of rheumatology, 34 6, 1415-25

Pigott, Teresa A; Prakash, Apurva; Arnold, Lesley M; Aaronson, Scott T; Mallinckrodt, Craig H; Wohlreich, Madelaine M 2007. Duloxetine versus escitalopram and placebo: an 8-month, double-blind trial in patients with major depressive disorder. Current medical research and opinion, 23 6, 1303-18

Strakowski, Stephen M; DelBello, Melissa P; Fleck, David E; Adler, Caleb M; Anthenelli, Robert M; Keck, Paul E; Arnold, Lesley M; Amicone, Jennifer 2007. Effects of co-occurring cannabis use disorders on the course of bipolar disorder after a first hospitalization for mania. Archives of general psychiatry, 64 1, 57-64

Arnold, Lesley M 2006. Management of psychiatric comorbidity in fibromyalgia. Current psychiatry reports, 8 3, 241-5

Arnold, Lesley M 2006. Biology and therapy of fibromyalgia. New therapies in fibromyalgia. Arthritis research & therapy, 8 4, 212

Arnold, Lesley M; Hudson, James I; Keck, Paul E; Auchenbach, Megan B; Javaras, Kristin N; Hess, Evelyn V 2006. Comorbidity of fibromyalgia and psychiatric disorders. The Journal of clinical psychiatry, 67 8, 1219-25

Arnold, Lesley M 2005. The nature of painful and somatic complaints in depressive disorders. CNS spectrums, 10 12 Suppl 19, 4-5

Arnold, Lesley M; Rosen, Amy; Pritchett, Yili Lu; D'Souza, Deborah N; Goldstein, David J; Iyengar, Smriti; Wernicke, Joachim F 2005. A randomized, double-blind, placebo-controlled trial of duloxetine in the treatment of women with fibromyalgia with or without major depressive disorder. Pain, 119 1-3, 5-15

Mease, Philip J; Clauw, Daniel J; Arnold, Lesley M; Goldenberg, Don L; Witter, James; Williams, David A; Simon, Lee S; Strand, C Vibeke; Bramson, Candace; Martin, Susan; Wright, Timothy M; Littman, Bruce; Wernicke, J F; Gendreau, R Michael; Crofford, Leslie J 2005. Fibromyalgia syndrome. The Journal of rheumatology, 32 11, 2270-7

Strakowski, Stephen M; DelBello, Melissa P; Fleck, David E; Adler, Caleb M; Anthenelli, Robert M; Keck, Paul E; Arnold, Lesley M; Amicone, Jennifer 2005. Effects of co-occurring alcohol abuse on the course of bipolar disorder following a first hospitalization for mania. Archives of general psychiatry, 62 8, 851-8

Arnold, Lesley M; Hudson, James I 2004. Comment on: Familial aggregation of depression in fibromyalgia: a community-based test of alternative hypotheses, Raphael et al., Pain 110 (2004) 449-460. Pain, 112 3, 409-10; author reply

Arnold, Lesley M; Hudson, James I; Hess, Evelyn V; Ware, Avis E; Fritz, Deborah A; Auchenbach, Megan B; Starck, Linsey O; Keck, Paul E 2004. Family study of fibromyalgia. Arthritis and rheumatism, 50 3, 944-52

Arnold, Lesley M; Keck, Paul E; Collins, Jacqueline; Wilson, Rodgers; Fleck, David E; Corey, Kimberly B; Amicone, Jennifer; Adebimpe, Victor R; Strakowski, Stephen M 2004. Ethnicity and first-rank symptoms in patients with psychosis. Schizophrenia research, 67 2-3, 207-12

Arnold, Lesley M; Lu, Yili; Crofford, Leslie J; Wohlreich, Madelaine; Detke, Michael J; Iyengar, Smriti; Goldstein, David J 2004. A double-blind, multicenter trial comparing duloxetine with placebo in the treatment of fibromyalgia patients with or without major depressive disorder. Arthritis and rheumatism, 50 9, 2974-84

Arnold, Lesley M; Strakowski, Stephen M; Schwiers, Michael L; Amicone, Jennifer; Fleck, David E; Corey, Kimberly B; Farrow, Jenni E 2004. Sex, ethnicity, and antipsychotic medication use in patients with psychosis. Schizophrenia research, 66 2-3, 169-75

Bennett, Aurora J; Arnold, Lesley M 2004. Use of a computerized evaluation system in a psychiatry clerkship. Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry, 28 3, 197-203

Hudson, James I; Arnold, Lesley M; Keck, Paul E; Auchenbach, Megan B; Pope, Harrison G 2004. Family study of fibromyalgia and affective spectrum disorder. Biological psychiatry, 56 11, 884-91

McElroy, Susan L; Shapira, Nathan A; Arnold, Lesley M; Keck, Paul E; Rosenthal, Norman R; Wu, Shu-Chen; Capece, Julie A; Fazzio, Lydia; Hudson, James I 2004. Topiramate in the long-term treatment of binge-eating disorder associated with obesity. The Journal of clinical psychiatry, 65 11, 1463-9

Arnold, Lesley M 2003. Gender differences in bipolar disorder. The Psychiatric clinics of North America, 26 3, 595-620

McElroy, Susan L; Arnold, Lesley M; Shapira, Nathan A; Keck, Paul E; Rosenthal, Norman R; Karim, M Rezaul; Kamin, Marc; Hudson, James I 2003. Topiramate in the treatment of binge eating disorder associated with obesity: a randomized, placebo-controlled trial. The American journal of psychiatry, 160 2, 255-61

Strakowski, Stephen M; Keck, Paul E; Arnold, Lesley M; Collins, Jacqueline; Wilson, Rodgers M; Fleck, David E; Corey, Kimberly B; Amicone, Jennifer; Adebimpe, Victor R 2003. Ethnicity and diagnosis in patients with affective disorders. The Journal of clinical psychiatry, 64 7, 747-54

Arnold, Lesley M 2002. Phenomenology and therapeutic options for dermatotillomania. Expert review of neurotherapeutics, 2 5, 725-30

Arnold, Lesley M; Hess, Evelyn V; Hudson, James I; Welge, Jeffrey A; Berno, Sarah E; Keck, Paul E 2002. A randomized, placebo-controlled, double-blind, flexible-dose study of fluoxetine in the treatment of women with fibromyalgia. The American journal of medicine, 112 3, 191-7

Arnold, Lesley M; McElroy, Susan L; Hudson, James I; Welge, Jeffrey A; Bennett, Aurora J; Keck, Paul E 2002. A placebo-controlled, randomized trial of fluoxetine in the treatment of binge-eating disorder. The Journal of clinical psychiatry, 63 11, 1028-33

Arnold, Lesley M. 1999. A Case Series of Women With Postpartum-Onset Obsessive-Compulsive Disorder. Primary care companion to the Journal of clinical psychiatry, 1 4, 103-108

Arnold, Lesley M . Understanding fatigue in major depressive disorder and other medical disorders. Psychosomatics, 49 3, 185-90

Arnold, Lesley M; Crofford, Leslie J; Martin, Susan A; Young, James P; Sharma, Uma . The effect of anxiety and depression on improvements in pain in a randomized, controlled trial of pregabalin for treatment of fibromyalgia. Pain medicine (Malden, Mass.), 8 8, 633-8

Arnold, Lesley M; Hudson, James I; Wang, Fujun; Wohlreich, Madelaine M; Prakash, Apurva; Kajdasz, Daniel K; Chappell, Amy S . Comparisons of the efficacy and safety of duloxetine for the treatment of fibromyalgia in patients with versus without major depressive disorder. The Clinical journal of pain, 25 6, 461-8

Arnold, Lesley M; Meyers, Adam L; Sunderajan, Prabha; Montano, C Brendan; Kass, Ethan; Trivedi, Madhukar; Wohlreich, Madelaine M . The effect of pain on outcomes in a trial of duloxetine treatment of major depressive disorder. Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists, 20 4, 187-93

Bennett, Aurora J; Arnold, Lesley M; Welge, Jeffrey A . Use of standardized patients during a psychiatry clerkship. Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry, 30 3, 185-90

Bennett, Aurora J; Roman, Brenda; Arnold, Lesley M; Kay, Jerald; Goldenhar, Linda M . Professionalism deficits among medical students: models of identification and intervention. Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry, 29 5, 426-32