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Department of

Neurology and Rehabilitation Medicine

Photo of  Kim Seroogy, PhD

Kim Seroogy, PhD

Vice Chair of Basic Research, Professor of Neurology, and Director of the Neuroscience Graduate Program

Education/Credentials
  • Bachelor's Degree: University of Wisconsin-Eau Claire
  • Doctoral Degree: University of California-Irvine
  • Fellowship: Karolinska Institute, Department of Histology & Neurobiology
  • Fellowship: University of North Carolina-Chapel Hill, Department of Physiology

Research/Clinical Interests

Neurology, Parkinson's Disease

Contact Information
  • Stetson Building
  • Suite 2300
  • 260 Stetson Street
  • Cincinnati, Ohio 45267-0525
  • Office 513-558-2968
  • Fax 513-558-4887
  • Email kim.seroogy@uc.edu

Peer Reviewed Publications

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Brumovsky, Pablo R; Seal, Rebecca P; Lundgren, Kerstin H; Seroogy, Kim B; Watanabe, Masahiko; Gebhart, G F 2013. Expression of vesicular glutamate transporters in sensory and autonomic neurons innervating the mouse bladder. The Journal of urology, 189 6, 2342-9

Hemmerle, A M; Dickerson, J W; Herman, J P; Seroogy, K B 2013. Stress exacerbates experimental Parkinson's disease. Molecular psychiatry, ,

Malet, M; Vieytes, C A; Lundgren, K H; Seal, R P; Tomasella, E; Seroogy, K B; Hökfelt, T; Gebhart, G F; Brumovsky, P R 2013. Transcript expression of vesicular glutamate transporters in lumbar dorsal root ganglia and the spinal cord of mice - Effects of peripheral axotomy or hindpaw inflammation. Neuroscience, 248C , 95-111

McKlveen, Jessica M; Myers, Brent; Flak, Jonathan N; Bundzikova, Jana; Solomon, Matia B; Seroogy, Kim B; Herman, James P 2013. Role of prefrontal cortex glucocorticoid receptors in stress and emotion. Biological psychiatry, 74 9, 672-9

Hemmerle, Ann M; Dickerson, Jonathan W; Herring, Nicole R; Schaefer, Tori L; Vorhees, Charles V; Williams, Michael T; Seroogy, Kim B 2012. (±)3,4-methylenedioxymethamphetamine ("Ecstacy") treatment modulates expression of neurotrophins and their receptors in multiple regions of adult rat brain. The Journal of comparative neurology, ,

Hemmerle, Ann M; Herman, James P; Seroogy, Kim B 2012. Stress, depression and Parkinson's disease. Experimental neurology, 233 1, 79-86

Suidan, Georgette L; Dickerson, Jonathan W; Johnson, Holly L; Chan, Theresa W; Pavelko, Kevin D; Pirko, Istvan; Seroogy, Kim B; Johnson, Aaron J 2012. Preserved vascular integrity and enhanced survival following neuropilin-1 inhibition in a mouse model of CD8 T cell-initiated CNS vascular permeability. Journal of neuroinflammation, 9 , 218

Braun, A A; Herring, N R; Schaefer, T L; Hemmerle, A M; Dickerson, J W; Seroogy, K B; Vorhees, C V; Williams, M T 2011. Neurotoxic (+)-methamphetamine treatment in rats increases brain-derived neurotrophic factor and tropomyosin receptor kinase B expression in multiple brain regions. Neuroscience, 184 , 164-71

Brumovsky, Pablo R; Robinson, David R; La, Jun-Ho; Seroogy, Kim B; Lundgren, Kerstin H; Albers, Kathryn M; Kiyatkin, Michael E; Seal, Rebecca P; Edwards, Robert H; Watanabe, Masahiko; Hökfelt, Tomas; Gebhart, G F 2011. Expression of vesicular glutamate transporters type 1 and 2 in sensory and autonomic neurons innervating the mouse colorectum. The Journal of comparative neurology, 519 16, 3346-66

Brumovsky, Pablo R; Seroogy, Kim B; Lundgren, Kerstin H; Watanabe, Masahiko; Hökfelt, Tomas; Gebhart, G F 2011. Some lumbar sympathetic neurons develop a glutamatergic phenotype after peripheral axotomy with a note on VGLUT?-positive perineuronal baskets. Experimental neurology, 230 2, 258-72

Suidan, Georgette L; Dickerson, Jonathan W; Chen, Yi; McDole, Jeremiah R; Tripathi, Pulak; Pirko, Istvan; Seroogy, Kim B; Johnson, Aaron J 2010. CD8 T cell-initiated vascular endothelial growth factor expression promotes central nervous system vascular permeability under neuroinflammatory conditions. Journal of immunology (Baltimore, Md. : 1950), 184 2, 1031-40

Dickerson, J W; Hemmerle, A M; Numan, S; Lundgren, K H; Seroogy, K B 2009. Decreased expression of ErbB4 and tyrosine hydroxylase mRNA and protein in the ventral midbrain of aged rats. Neuroscience, 163 1, 482-9

Yurek, David M; Fletcher, Anita M; Smith, George M; Seroogy, Kim B; Ziady, Assem G; Molter, Joseph; Kowalczyk, Tomasz H; Padegimas, Linas; Cooper, Mark J 2009. Long-term transgene expression in the central nervous system using DNA nanoparticles. Molecular therapy : the journal of the American Society of Gene Therapy, 17 4, 641-50

Cass, Wayne A; Peters, Laura E; Harned, Michael E; Seroogy, Kim B 2006. Protection by GDNF and other trophic factors against the dopamine-depleting effects of neurotoxic doses of methamphetamine. Annals of the New York Academy of Sciences, 1074 , 272-81

Numan, Suzanne; Gall, Christine M; Seroogy, Kim B 2005. Developmental expression of neurotrophins and their receptors in postnatal rat ventral midbrain. Journal of molecular neuroscience : MN, 27 2, 245-60

Yurek, David M; Zhang, Lixin; Fletcher-Turner, Anita; Seroogy, Kim B 2004. Supranigral injection of neuregulin1-beta induces striatal dopamine overflow. Brain research, 1028 1, 116-9

Zhang, Lixin; Fletcher-Turner, Anita; Marchionni, Mark A; Apparsundaram, Subbu; Lundgren, Kerstin H; Yurek, David M; Seroogy, Kim B 2004. Neurotrophic and neuroprotective effects of the neuregulin glial growth factor-2 on dopaminergic neurons in rat primary midbrain cultures. Journal of neurochemistry, 91 6, 1358-68

Dimayuga, Filomena O; Ding, Qunxing; Keller, Jeffrey N; Marchionni, Mark A; Seroogy, Kim B; Bruce-Keller, Annadora J 2003. The neuregulin GGF2 attenuates free radical release from activated microglial cells. Journal of neuroimmunology, 136 1-2, 67-74

Hicks, R R; Zhang, L; Atkinson, A; Stevenon, M; Veneracion, M; Seroogy, K B 2002. Environmental enrichment attenuates cognitive deficits, but does not alter neurotrophin gene expression in the hippocampus following lateral fluid percussion brain injury. Neuroscience, 112 3, 631-7

Lee, Jaewon; Seroogy, Kim B; Mattson, Mark P 2002. Dietary restriction enhances neurotrophin expression and neurogenesis in the hippocampus of adult mice. Journal of neurochemistry, 80 3, 539-47

Kornblum, H I; Yanni, D S; Easterday, M C; Seroogy, K B 2000. Expression of the EGF receptor family members ErbB2, ErbB3, and ErbB4 in germinal zones of the developing brain and in neurosphere cultures containing CNS stem cells. Developmental neuroscience, 22 1-2, 16-24

Yurek, D M; Seroogy, K B 2000. Differential expression of neurotrophin and neurotrophin receptor mRNAs in and adjacent to fetal midbrain grafts implanted into the dopamine-denervated striatum. The Journal of comparative neurology, 423 3, 462-73

Zhang, L; Dhillon, H S; Barron, S; Hicks1, R R; Prasad, R M; Seroogy, K B 2000. Effects of chronic ethanol administration on expression of BDNF and trkB mRNAs in rat hippocampus after experimental brain injury. Brain research. Molecular brain research, 79 1-2, 174-9

Hicks, R R; Li, C; Zhang, L; Dhillon, H S; Prasad, M R; Seroogy, K B 1999. Alterations in BDNF and trkB mRNA levels in the cerebral cortex following experimental brain trauma in rats. Journal of neurotrauma, 16 6, 501-10

Hicks, R R; Martin, V B; Zhang, L; Seroogy, K B 1999. Mild experimental brain injury differentially alters the expression of neurotrophin and neurotrophin receptor mRNAs in the hippocampus. Experimental neurology, 160 2, 469-78

Kornblum, H I; Zurcher, S D; Werb, Z; Derynck, R; Seroogy, K B 1999. Multiple trophic actions of heparin-binding epidermal growth factor (HB-EGF) in the central nervous system. The European journal of neuroscience, 11 9, 3236-46

Noble, F; Wank, S A; Crawley, J N; Bradwejn, J; Seroogy, K B; Hamon, M; Roques, B P 1999. International Union of Pharmacology. XXI. Structure, distribution, and functions of cholecystokinin receptors. Pharmacological reviews, 51 4, 745-81

Noble,F., Wank,S. A., Crawley,J. N., Bradwejn,J., Seroogy,K. B., Hamon,M., Roques,B. P. 1999. International Union of Pharmacology. XXI. Structure, distribution, and functions of cholecystokinin receptors Pharmacological reviews, 51 4, 745

Numan, S; Seroogy, K B 1999. Expression of trkB and trkC mRNAs by adult midbrain dopamine neurons: a double-label in situ hybridization study. The Journal of comparative neurology, 403 3, 295-308

Opanashuk, L A; Mark, R J; Porter, J; Damm, D; Mattson, M P; Seroogy, K B 1999. Heparin-binding epidermal growth factor-like growth factor in hippocampus: modulation of expression by seizures and anti-excitotoxic action. The Journal of neuroscience : the official journal of the Society for Neuroscience, 19 1, 133-46

Hicks, R R; Zhang, L; Dhillon, H S; Prasad, M R; Seroogy, K B 1998. Expression of trkB mRNA is altered in rat hippocampus after experimental brain trauma. Brain research. Molecular brain research, 59 2, 264-8

Hicks, Ramona R.; Boggs, Arden; Leider, Denise; Kraemer, Philip; Brown, Russell; Scheff, Stephen W.; Seroogy, Kim B. 1998. Effects of Exercise Following Lateral Fluid Percussion Brain Injury in Rats. Restorative neurology and neuroscience, 12 1, 41-47

Numan, S; Lane-Ladd, S B; Zhang, L; Lundgren, K H; Russell, D S; Seroogy, K B; Nestler, E J 1998. Differential regulation of neurotrophin and trk receptor mRNAs in catecholaminergic nuclei during chronic opiate treatment and withdrawal. The Journal of neuroscience : the official journal of the Society for Neuroscience, 18 24, 10700-8

Hicks, R R; Numan, S; Dhillon, H S; Prasad, M R; Seroogy, K B 1997. Alterations in BDNF and NT-3 mRNAs in rat hippocampus after experimental brain trauma. Brain research. Molecular brain research, 48 2, 401-6

Kornblum, H I; Hussain, R J; Bronstein, J M; Gall, C M; Lee, D C; Seroogy, K B 1997. Prenatal ontogeny of the epidermal growth factor receptor and its ligand, transforming growth factor alpha, in the rat brain. The Journal of comparative neurology, 380 2, 243-61

Numan, S; Seroogy, K B 1997. Increased expression of trkB mRNA in rat caudate--putamen following 6-OHDA lesions of the nigrostriatal pathway. The European journal of neuroscience, 9 3, 489-95

Berkowitz, E A; Seroogy, K B; Schroeder, J A; Russell, W E; Evans, E P; Riedel, R F; Phillips, H K; Harrison, C A; Lee, D C; Luetteke, N C 1996. Characterization of the mouse transforming growth factor alpha gene: its expression during eyelid development and in waved 1 tissues. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 7 9, 1271-82

Kornblum, H I; Gall, C M; Seroogy, K B; Lauterborn, J C 1995. A subpopulation of striatal gabaergic neurons expresses the epidermal growth factor receptor. Neuroscience, 69 4, 1025-1029

Numan, S; Lundgren, K H; Wright, D E; Herman, J P; Seroogy, K B 1995. Increased expression of 5HT2 receptor mRNA in rat striatum following 6-OHDA lesions of the adult nigrostriatal pathway. Brain research. Molecular brain research, 29 2, 391-6

Seroogy, K B; Gall, C M; Lee, D C; Kornblum, H I 1995. Proliferative zones of postnatal rat brain express epidermal growth factor receptor mRNA. Brain research, 670 1, 157-64

Wright, D E; Seroogy, K B; Lundgren, K H; Davis, B M; Jennes, L 1995. Comparative localization of serotonin1A, 1C, and 2 receptor subtype mRNAs in rat brain. The Journal of comparative neurology, 351 3, 357-73

Davis, B M; Albers, K M; Seroogy, K B; Katz, D M 1994. Overexpression of nerve growth factor in transgenic mice induces novel sympathetic projections to primary sensory neurons. The Journal of comparative neurology, 349 3, 464-74

Seroogy, K B; Lundgren, K H; Tran, T M; Guthrie, K M; Isackson, P J; Gall, C M 1994. Dopaminergic neurons in rat ventral midbrain express brain-derived neurotrophic factor and neurotrophin-3 mRNAs. The Journal of comparative neurology, 342 3, 321-34

Seroogy, K B; Numan, S; Gall, C M; Lee, D C; Kornblum, H I 1994. Expression of EGF receptor mRNA in rat nigrostriatal system. Neuroreport, 6 1, 105-8

Seroogy, K B; Gall, C M 1993. Expression of neurotrophins by midbrain dopaminergic neurons. Experimental neurology, 124 1, 119-28

Seroogy, K B; Lundgren, K H; Lee, D C; Guthrie, K M; Gall, C M 1993. Cellular localization of transforming growth factor-alpha mRNA in rat forebrain. Journal of neurochemistry, 60 5, 1777-82

Ceccatelli, S; Seroogy, K B; Millhorn, D E; Terenius, L 1992. Presence of a dynorphin-like peptide in a restricted subpopulation of catecholaminergic neurons in rat nucleus tractus solitarii. Brain research, 589 2, 225-30

Fallon, J H; Di Salvo, J; Loughlin, S E; Gimenez-Gallego, G; Seroogy, K B; Bradshaw, R A; Morrison, R S; Ciofi, P; Thomas, K A 1992. Localization of acidic fibroblast growth factor within the mouse brain using biochemical and immunocytochemical techniques. Growth factors (Chur, Switzerland), 6 2, 139-57

Gall, C M; Gold, S J; Isackson, P J; Seroogy, K B 1992. Brain-derived neurotrophic factor and neurotrophin-3 mRNAs are expressed in ventral midbrain regions containing dopaminergic neurons. Molecular and cellular neurosciences, 3 1, 56-63

Bayliss, D A; Seroogy, K B; Millhorn, D E 1991. Distribution and regulation by estrogen of progesterone receptor in the hypothalamus of the cat. Endocrinology, 128 5, 2610-7

Czyzyk-Krzeska, M F; Bayliss, D A; Seroogy, K B; Millhorn, D E 1991. Gene expression for peptides in neurons of the petrosal and nodose ganglia in rat. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale, 83 2, 411-8

Seroogy, K B; Bayliss, D A; Szymeczek, C L; Hökfelt, T; Millhorn, D E 1991. Transient expression of somatostatin messenger RNA and peptide in the hypoglossal nucleus of the neonatal rat. Brain research. Developmental brain research, 60 2, 241-52

Seroogy, K B; Han, V K; Lee, D C 1991. Regional expression of transforming growth factor-alpha mRNA in the rat central nervous system. Neuroscience letters, 125 2, 241-5

Seroogy, K B; Mohapatra, N K; Lund, P K; Réthelyi, M; McGehee, D S; Perl, E R 1990. Species-specific expression of cholecystokinin messenger RNA in rodent dorsal root ganglia. Brain research. Molecular brain research, 7 2, 171-6

Seroogy, K B; Dangaran, K; Lim, S; Haycock, J W; Fallon, J H 1989. Ventral mesencephalic neurons containing both cholecystokinin- and tyrosine hydroxylase-like immunoreactivities project to forebrain regions. The Journal of comparative neurology, 279 3, 397-414

Seroogy, K B; Fallon, J H 1989. Forebrain projections from cholecystokininlike-immunoreactive neurons in the rat midbrain. The Journal of comparative neurology, 279 3, 415-35

Code, R A; Seroogy, K B; Fallon, J H 1987. Some transforming growth factor-alpha connections and their colocalization with enkephalin in the rat central nervous system. Brain research, 421 1-2, 401-5

Gall, C M; Hendry, S H; Seroogy, K B; Jones, E G; Haycock, J W 1987. Evidence for coexistence of GABA and dopamine in neurons of the rat olfactory bulb. The Journal of comparative neurology, 266 3, 307-18

Hunt, C A; Seroogy, K B; Gall, C M; Jones, E G 1987. Cholecystokinin innervation of rat thalamus, including fibers to ventroposterolateral nucleus from dorsal column nuclei. Brain research, 426 2, 257-69

Seroogy, K B; Mehta, A; Fallon, J H 1987. Neurotensin and cholecystokinin coexistence within neurons of the ventral mesencephalon: projections to forebrain. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale, 68 2, 277-89

Gall, C; Seroogy, K B; Brecha, N 1986. Distribution of VIP- and NPY-like immunoreactivities in rat main olfactory bulb. Brain research, 374 2, 389-94

Ribak, C E; Seress, L; Peterson, G M; Seroogy, K B; Fallon, J H; Schmued, L C 1986. A GABAergic inhibitory component within the hippocampal commissural pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience, 6 12, 3492-8

Fallon, J H; Seroogy, K B 1985. The distribution and some connections of cholecystokinin neurons in the rat brain. Annals of the New York Academy of Sciences, 448 , 121-32

Seroogy, K B; Brecha, N; Gall, C 1985. Distribution of cholecystokinin-like immunoreactivity in the rat main olfactory bulb. The Journal of comparative neurology, 239 4, 373-83

Seroogy, K B; Fallon, J H; Loughlin, S E; Leslie, F M 1985. Few cortical cholecystokinin immunoreactive neurons have long projections. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale, 59 3, 533-42

Fallon, J H; Seroogy, K B 1984. Visual and auditory pathways contain cholecystokinin: evidence from immunofluorescence and retrograde tracing. Neuroscience letters, 45 1, 81-7

Fallon, J H; Seroogy, K B; Loughlin, S E; Morrison, R S; Bradshaw, R A; Knaver, D J; Cunningham, D D 1984. Epidermal growth factor immunoreactive material in the central nervous system: location and development. Science (New York, N.Y.), 224 4653, 1107-9

Seroogy, K B; Seress, L; Ribak, C E 1983. Ultrastructure of commissural neurons of the hilar region in the hippocampal dentate gyrus. Experimental neurology, 82 3, 594-608

Ruiz-Argüelles, A; Seroogy, K B; Ritts, R E 1982. In vitro effect of cimetidine on human cell-mediated cytotoxicity. I. Inhibition of natural killer cell activity. Cellular immunology, 69 1, 1-12

Bruce, Laura L; Kornblum, Harley I; Seroogy, Kim B . Comparison of thalamic populations in mammals and birds: expression of ErbB4 mRNA. Brain research bulletin, 57 3-4, 455-61