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Molecular Genetics, Biochemistry & Microbiology

Photo of  Gary Shull, Ph.D.

Gary Shull, Ph.D.

Professor of Molecular Genetics, Biochemistry and Microbiology

Education/Credentials
  • PhD: North Carolina State University

Research/Clinical Interests

I have a long-term interest in the mechanisms of ion transport and the physiological and pathophysiological processes involving various ion transporters. Our studies are contributing to a better understanding of the cellular and physiological functions of these ion transporters, a number of which serve as important drug receptors, and this in turn is leading to a better understanding of their roles in human disease.

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Peer Reviewed Publications

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Catalán, Marcelo A; Kondo, Yusuke; Peña-Munzenmayer, Gaspar; Jaramillo, Yasna; Liu, Frances; Choi, Sooji; Crandall, Edward; Borok, Zea; Flodby, Per; Shull, Gary E; Melvin, James E 2015. A fluid secretion pathway unmasked by acinar-specific Tmem16A gene ablation in the adult mouse salivary gland. Proceedings of the National Academy of Sciences of the United States of America, 112 7, 2263-8

Li, Xiao C; Shull, Gary E; Miguel-Qin, Elisa; Chen, Fang; Zhuo, Jia L 2015. Role of the Na+/H+ exchanger 3 in angiotensin II-induced hypertension in NHE3-deficient mice with transgenic rescue of NHE3 in small intestines. Physiological reports, 3 11,

Li, Xiao C; Shull, Gary E; Miguel-Qin, Elisa; Zhuo, Jia L 2015. Role of the Na+/H+ exchanger 3 in angiotensin II-induced hypertension. Physiological genomics, 47 10, 479-87

Nighot, Meghali P; Nighot, Prashant K; Ma, Thomas Y; Malinowska, Danuta H; Shull, Gary E; Cuppoletti, John; Blikslager, Anthony T 2015. Genetic Ablation of the ClC-2 Cl- Channel Disrupts Mouse Gastric Parietal Cell Acid Secretion. PloS one, 10 9, e0138174

Peña-Münzenmayer, Gaspar; Catalán, Marcelo A; Kondo, Yusuke; Jaramillo, Yasna; Liu, Frances; Shull, Gary E; Melvin, James E 2015. Ae4 (Slc4a9) Anion Exchanger Drives Cl- Uptake-dependent Fluid Secretion by Mouse Submandibular Gland Acinar Cells. The Journal of biological chemistry, 290 17, 10677-88

Prasad, Vikram; Lorenz, John N; Lasko, Valerie M; Nieman, Michelle L; Huang, Wei; Wang, Yigang; Wieczorek, David W; Shull, Gary E 2015. SERCA2 Haploinsufficiency in a Mouse Model of Darier Disease Causes a Selective Predisposition to Heart Failure. BioMed research international, 2015 , 251598

Wang, Jing; Sun, Chongxiu; Gerdes, Norbert; Liu, Conglin; Liao, Mengyang; Liu, Jian; Shi, Michael A; He, Aina; Zhou, Yi; Sukhova, Galina K; Chen, Huimei; Cheng, Xian Wu; Kuzuya, Masafumi; Murohara, Toyoaki; Zhang, Jie; Cheng, Xiang; Jiang, Mengmeng; Shull, Gary E; Rogers, Shaunessy; Yang, Chao-Ling; Ke, Qiang; Jelen, Sabina; Bindels, René; Ellison, David H; Jarolim, Petr; Libby, Peter; Shi, Guo-Ping 2015. Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter. Nature medicine, 21 7, 820-6

Prasad, Vikram; Chirra, Shivani; Kohli, Rohit; Shull, Gary E 2014. NHE1 deficiency in liver: implications for non-alcoholic fatty liver disease. Biochemical and biophysical research communications, 450 2, 1027-31

Prasad, Vikram; Lorenz, John N; Lasko, Valerie M; Nieman, Michelle L; Jiang, Min; Gao, Xu; Rubinstein, Jack; Wieczorek, David F; Shull, Gary E 2014. Ablation of plasma membrane Ca(2+)-ATPase isoform 4 prevents development of hypertrophy in a model of hypertrophic cardiomyopathy. Journal of molecular and cellular cardiology, 77 , 53-63

Theparambil, Shefeeq M; Ruminot, Iván; Schneider, Hans-Peter; Shull, Gary E; Deitmer, Joachim W 2014. The electrogenic sodium bicarbonate cotransporter NBCe1 is a high-affinity bicarbonate carrier in cortical astrocytes. The Journal of neuroscience : the official journal of the Society for Neuroscience, 34 4, 1148-57

Wang, Hong-Sheng; Chen, Yamei; Vairamani, Kanimozhi; Shull, Gary E 2014. Critical role of bicarbonate and bicarbonate transporters in cardiac function. World journal of biological chemistry, 5 3, 334-45

Aihara, Eitaro; Hentz, Courtney L; Korman, Abraham M; Perry, Nicholas P J; Prasad, Vikram; Shull, Gary E; Montrose, Marshall H 2013. In vivo epithelial wound repair requires mobilization of endogenous intracellular and extracellular calcium. The Journal of biological chemistry, 288 47, 33585-97

Coury, Fabienne; Zenger, Serhan; Stewart, Andrew K; Stephens, Sebastien; Neff, Lynn; Tsang, Kelly; Shull, Gary E; Alper, Seth L; Baron, Roland; Aliprantis, Antonios O 2013. SLC4A2-mediated Cl-/HCO3- exchange activity is essential for calpain-dependent regulation of the actin cytoskeleton in osteoclasts. Proceedings of the National Academy of Sciences of the United States of America, 110 6, 2163-8

Engevik, Melinda A; Aihara, Eitaro; Montrose, Marshall H; Shull, Gary E; Hassett, Daniel J; Worrell, Roger T 2013. Loss of NHE3 alters gut microbiota composition and influences Bacteroides thetaiotaomicron growth. American journal of physiology. Gastrointestinal and liver physiology, 305 10, G697-711

Engevik, Melinda A; Hickerson, Annelies; Shull, Gary E; Worrell, Roger T 2013. Acidic conditions in the NHE2(-/-) mouse intestine result in an altered mucosa-associated bacterial population with changes in mucus oligosaccharides. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 32 7, 111-28

Prasad, Vikram; Lorenz, John N; Lasko, Valerie M; Nieman, Michelle L; Al Moamen, Nabeel J; Shull, Gary E 2013. Loss of the AE3 Cl(-)/HCO(-) 3 exchanger in mice affects rate-dependent inotropy and stress-related AKT signaling in heart. Frontiers in physiology, 4 , 399

Prasad, Vikram; Lorenz, John N; Miller, Marian L; Vairamani, Kanimozhi; Nieman, Michelle L; Wang, Yigang; Shull, Gary E 2013. Loss of NHE1 activity leads to reduced oxidative stress in heart and mitigates high-fat diet-induced myocardial stress. Journal of molecular and cellular cardiology, 65 , 33-42

Schultheis, Patrick J; Fleming, Sheila M; Clippinger, Amy K; Lewis, Jada; Tsunemi, Taiji; Giasson, Benoit; Dickson, Dennis W; Mazzulli, Joseph R; Bardgett, Mark E; Haik, Kristi L; Ekhator, Osunde; Chava, Anil Kumar; Howard, John; Gannon, Matt; Hoffman, Elizabeth; Chen, Yinhuai; Prasad, Vikram; Linn, Stephen C; Tamargo, Rafael J; Westbroek, Wendy; Sidransky, Ellen; Krainc, Dimitri; Shull, Gary E 2013. Atp13a2-deficient mice exhibit neuronal ceroid lipofuscinosis, limited ?-synuclein accumulation and age-dependent sensorimotor deficits. Human molecular genetics, 22 10, 2067-82

Chen, Mingmin; Praetorius, Jeppe; Zheng, Wen; Xiao, Fang; Riederer, Brigitte; Singh, Anurag Kumar; Stieger, Nicole; Wang, Jian; Shull, Gary E; Aalkjaer, Christian; Seidler, Ursula 2012. The electroneutral Na?:HCO?? cotransporter NBCn1 is a major pHi regulator in murine duodenum. The Journal of physiology, 590 Pt 14, 3317-33

Pan, Wanling; Borovac, Jelena; Spicer, Zachary; Hoenderop, Joost G; Bindels, René J; Shull, Gary E; Doschak, Michael R; Cordat, Emmanuelle; Alexander, R Todd 2012. The epithelial sodium/proton exchanger, NHE3, is necessary for renal and intestinal calcium (re)absorption. American journal of physiology. Renal physiology, 302 8, F943-56

Soleimani, Manoocher; Barone, Sharon; Xu, Jie; Shull, Gary E; Siddiqui, Faraz; Zahedi, Kamyar; Amlal, Hassane 2012. Double knockout of pendrin and Na-Cl cotransporter (NCC) causes severe salt wasting, volume depletion, and renal failure. Proceedings of the National Academy of Sciences of the United States of America, 109 33, 13368-73

Al Moamen, Nabeel J; Prasad, Vikram; Bodi, Ilona; Miller, Marian L; Neiman, Michelle L; Lasko, Valerie M; Alper, Seth L; Wieczorek, David F; Lorenz, John N; Shull, Gary E 2011. Loss of the AE3 anion exchanger in a hypertrophic cardiomyopathy model causes rapid decompensation and heart failure. Journal of molecular and cellular cardiology, 50 1, 137-46

Miller, Marian L; Andringa, Anastasia; Schultheis, Patrick J; Shull, Gary E 2011. Loss of the NHE2 Na+/H+ exchanger in mice results in dilation of folliculo-stellate cell canaliculi. Journal of biomedicine & biotechnology, 2011 , 510827

Ruminot, Iván; Gutiérrez, Robin; Peña-Münzenmayer, Gaspar; Añazco, Carolina; Sotelo-Hitschfeld, Tamara; Lerchundi, Rodrigo; Niemeyer, María Isabel; Shull, Gary E; Barros, L Felipe 2011. NBCe1 mediates the acute stimulation of astrocytic glycolysis by extracellular K+. The Journal of neuroscience : the official journal of the Society for Neuroscience, 31 40, 14264-71

Bourgeois, Soline; Meer, Leonie Van; Wootla, Bharath; Bloch-Faure, May; Chambrey, Régine; Shull, Gary E; Gawenis, Lara R; Houillier, Pascal 2010. NHE4 is critical for the renal handling of ammonia in rodents. The Journal of clinical investigation, 120 6, 1895-904

Bradford, Emily M; Miller, Marian L; Prasad, Vikram; Nieman, Michelle L; Gawenis, Lara R; Berryman, Mark; Lorenz, John N; Tso, Patrick; Shull, Gary E 2010. CLIC5 mutant mice are resistant to diet-induced obesity and exhibit gastric hemorrhaging and increased susceptibility to torpor. American journal of physiology. Regulatory, integrative and comparative physiology, 298 6, R1531-42

Chen, Xinzhi; Kintner, Douglas B; Baba, Akemichi; Matsuda, Toshio; Shull, Gary E; Sun, Dandan 2010. Protein aggregation in neurons following OGD: a role for Na+ and Ca2+ ionic dysregulation. Journal of neurochemistry, 112 1, 173-82

Gawenis, Lara R; Bradford, Emily M; Alper, Seth L; Prasad, Vikram; Shull, Gary E 2010. AE2 Cl-/HCO3- exchanger is required for normal cAMP-stimulated anion secretion in murine proximal colon. American journal of physiology. Gastrointestinal and liver physiology, 298 4, G493-503

Leviel, Françoise; Hübner, Christian A; Houillier, Pascal; Morla, Luciana; El Moghrabi, Soumaya; Brideau, Gaëlle; Hassan, Hatim; Hatim, Hassan; Parker, Mark D; Kurth, Ingo; Kougioumtzes, Alexandra; Sinning, Anne; Pech, Vladimir; Riemondy, Kent A; Miller, R Lance; Hummler, Edith; Shull, Gary E; Aronson, Peter S; Doucet, Alain; Wall, Susan M; Chambrey, Régine; Eladari, Dominique 2010. The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice. The Journal of clinical investigation, 120 5, 1627-35

Liu, Yan; Kintner, Douglas B; Begum, Gulnaz; Algharabli, Jehad; Cengiz, Pelin; Shull, Gary E; Liu, Xiang-Jun; Sun, Dandan 2010. Endoplasmic reticulum Ca2+ signaling and mitochondrial Cyt c release in astrocytes following oxygen and glucose deprivation. Journal of neurochemistry, 114 5, 1436-46

Miller, Marian L; Andringa, Anastasia; Zavros, Yana; Bradford, Emily M; Shull, Gary E 2010. Volume density, distribution, and ultrastructure of secretory and basolateral membranes and mitochondria predict parietal cell secretory (dys)function. Journal of biomedicine & biotechnology, 2010 , 394198

Shao, Jiahong; Gumz, Michelle L; Cain, Brian D; Xia, Shen-Ling; Shull, Gary E; van Driel, Ian R; Wingo, Charles S 2010. Pharmacological profiles of the murine gastric and colonic H,K-ATPases. Biochimica et biophysica acta, 1800 9, 906-11

Bradford, Emily M; Sartor, Maureen A; Gawenis, Lara R; Clarke, Lane L; Shull, Gary E 2009. Reduced NHE3-mediated Na+ absorption increases survival and decreases the incidence of intestinal obstructions in cystic fibrosis mice. American journal of physiology. Gastrointestinal and liver physiology, 296 4, G886-98

Sinkins, William G; Estacion, Mark; Prasad, Vikram; Goel, Monu; Shull, Gary E; Kunze, Diana L; Schilling, William P 2009. Maitotoxin converts the plasmalemmal Ca(2+) pump into a Ca(2+)-permeable nonselective cation channel. American journal of physiology. Cell physiology, 297 6, C1533-43

Wu, Xu; Chang, Baojun; Blair, N Scott; Sargent, Michelle; York, Allen J; Robbins, Jeffrey; Shull, Gary E; Molkentin, Jeffery D 2009. Plasma membrane Ca2+-ATPase isoform 4 antagonizes cardiac hypertrophy in association with calcineurin inhibition in rodents. The Journal of clinical investigation, 119 4, 976-85

Yu, Haoyang; Riederer, Brigitte; Stieger, Nicole; Boron, Walter F; Shull, Gary E; Manns, Michael P; Seidler, Ursula E; Bachmann, Oliver 2009. Secretagogue stimulation enhances NBCe1 (electrogenic Na(+)/HCO(3)(-) cotransporter) surface expression in murine colonic crypts. American journal of physiology. Gastrointestinal and liver physiology, 297 6, G1223-31

Hanner, Fiona; Chambrey, Régine; Bourgeois, Soline; Meer, Elliott; Mucsi, István; Rosivall, László; Shull, Gary E; Lorenz, John N; Eladari, Dominique; Peti-Peterdi, János 2008. Increased renal renin content in mice lacking the Na+/H+ exchanger NHE2. American journal of physiology. Renal physiology, 294 4, F937-44

Luo, Jing; Wang, Yanping; Chen, Hai; Kintner, Douglas B; Cramer, Sam W; Gerdts, Josiah K; Chen, Xinzhi; Shull, Gary E; Philipson, Kenneth D; Sun, Dandan 2008. A concerted role of Na+ -K+ -Cl- cotransporter and Na+/Ca2+ exchanger in ischemic damage. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 28 4, 737-46

Lynch, I Jeanette; Rudin, Alicia; Xia, Shen-Ling; Stow, Lisa R; Shull, Gary E; Weiner, I David; Cain, Brian D; Wingo, Charles S 2008. Impaired acid secretion in cortical collecting duct intercalated cells from H-K-ATPase-deficient mice: role of HKalpha isoforms. American journal of physiology. Renal physiology, 294 3, F621-7

Prasad, Vikram; Bodi, Ilona; Meyer, Jamie W; Wang, Yigang; Ashraf, Muhammad; Engle, Sandra J; Doetschman, Thomas; Sisco, Karena; Nieman, Michelle L; Miller, Marian L; Lorenz, John N; Shull, Gary E 2008. Impaired cardiac contractility in mice lacking both the AE3 Cl-/HCO3- exchanger and the NKCC1 Na+-K+-2Cl- cotransporter: effects on Ca2+ handling and protein phosphatases. The Journal of biological chemistry, 283 46, 31303-14

Xu, Jie; Song, Penghong; Miller, Marian L; Borgese, Frank; Barone, Sharon; Riederer, Brigitte; Wang, Zhaohui; Alper, Seth L; Forte, John G; Shull, Gary E; Ehrenfeld, Jordi; Seidler, Ursula; Soleimani, Manoocher 2008. Deletion of the chloride transporter Slc26a9 causes loss of tubulovesicles in parietal cells and impairs acid secretion in the stomach. Proceedings of the National Academy of Sciences of the United States of America, 105 46, 17955-60

Alvarez, Bernardo V; Gilmour, Gregory S; Mema, Silvina C; Martin, Brent T; Shull, Gary E; Casey, Joseph R; Sauvé, Yves 2007. Blindness caused by deficiency in AE3 chloride/bicarbonate exchanger. PloS one, 2 9, e839

Diaz, Rodney C; Vazquez, Ana Elena; Dou, Hongwei; Wei, Dongguang; Cardell, Emma Lou; Lingrel, Jerry; Shull, Gary E; Doyle, Karen Jo; Yamoah, Ebenezer N 2007. Conservation of hearing by simultaneous mutation of Na,K-ATPase and NKCC1. Journal of the Association for Research in Otolaryngology : JARO, 8 4, 422-34

Ficarella, R; Di Leva, F; Bortolozzi, M; Ortolano, S; Donaudy, F; Petrillo, M; Melchionda, S; Lelli, A; Domi, T; Fedrizzi, L; Lim, D; Shull, G E; Gasparini, P; Brini, M; Mammano, F; Carafoli, E 2007. A functional study of plasma-membrane calcium-pump isoform 2 mutants causing digenic deafness. Proceedings of the National Academy of Sciences of the United States of America, 104 5, 1516-21

Gawenis, Lara R; Bradford, Emily M; Prasad, Vikram; Lorenz, John N; Simpson, Janet E; Clarke, Lane L; Woo, Alison L; Grisham, Christina; Sanford, L Philip; Doetschman, Thomas; Miller, Marian L; Shull, Gary E 2007. Colonic anion secretory defects and metabolic acidosis in mice lacking the NBC1 Na+/HCO3- cotransporter. The Journal of biological chemistry, 282 12, 9042-52

Kintner, Douglas B; Luo, Jing; Gerdts, Josiah; Ballard, Andy J; Shull, Gary E; Sun, Dandan 2007. Role of Na+-K+-Cl- cotransport and Na+/Ca2+ exchange in mitochondrial dysfunction in astrocytes following in vitro ischemia. American journal of physiology. Cell physiology, 292 3, C1113-22

Liu, Li; Ishida, Yukisato; Okunade, Gbolahan; Pyne-Geithman, Gail J; Shull, Gary E; Paul, Richard J 2007. Distinct roles of PMCA isoforms in Ca2+ homeostasis of bladder smooth muscle: evidence from PMCA gene-ablated mice. American journal of physiology. Cell physiology, 292 1, C423-31

Luo, Jing; Kintner, Douglas B; Shull, Gary E; Sun, Dandan 2007. ERK1/2-p90RSK-mediated phosphorylation of Na+/H+ exchanger isoform 1. A role in ischemic neuronal death. The Journal of biological chemistry, 282 38, 28274-84

Luo, Jing; Wang, Yanping; Chen, Xinzhi; Chen, Hai; Kintner, Douglas B; Shull, Gary E; Philipson, Kenneth D; Sun, Dandan 2007. Increased tolerance to ischemic neuronal damage by knockdown of Na+-Ca2+ exchanger isoform 1. Annals of the New York Academy of Sciences, 1099 , 292-305

Okunade, Gbolahan W; Miller, Marian L; Azhar, Mohamad; Andringa, Anastasia; Sanford, L Philip; Doetschman, Thomas; Prasad, Vikram; Shull, Gary E 2007. Loss of the Atp2c1 secretory pathway Ca(2+)-ATPase (SPCA1) in mice causes Golgi stress, apoptosis, and midgestational death in homozygous embryos and squamous cell tumors in adult heterozygotes. The Journal of biological chemistry, 282 36, 26517-27

Prasad, Vikram; Okunade, Gbolahan; Liu, Li; Paul, Richard J; Shull, Gary E 2007. Distinct phenotypes among plasma membrane Ca2+-ATPase knockout mice. Annals of the New York Academy of Sciences, 1099 , 276-86

Simpson, Janet E; Schweinfest, Clifford W; Shull, Gary E; Gawenis, Lara R; Walker, Nancy M; Boyle, Kathryn T; Soleimani, Manoocher; Clarke, Lane L 2007. PAT-1 (Slc26a6) is the predominant apical membrane Cl-/HCO3- exchanger in the upper villous epithelium of the murine duodenum. American journal of physiology. Gastrointestinal and liver physiology, 292 4, G1079-88

Guan, Yanfang; Dong, Jin; Tackett, Lixuan; Meyer, Jamie W; Shull, Gary E; Montrose, Marshall H 2006. NHE2 is the main apical NHE in mouse colonic crypts but an alternative Na+-dependent acid extrusion mechanism is upregulated in NHE2-null mice. American journal of physiology. Gastrointestinal and liver physiology, 291 4, G689-99

Liu, Li; Ishida, Yukisato; Okunade, Gbolahan; Shull, Gary E; Paul, Richard J 2006. Role of plasma membrane Ca2+-ATPase in contraction-relaxation processes of the bladder: evidence from PMCA gene-ablated mice. American journal of physiology. Cell physiology, 290 4, C1239-47

Lorenz, John N; Dostanic-Larson, Iva; Shull, Gary E; Lingrel, Jerry B 2006. Ouabain inhibits tubuloglomerular feedback in mutant mice with ouabain-sensitive alpha1 Na,K-ATPase. Journal of the American Society of Nephrology : JASN, 17 9, 2457-63

Luo, J; Chen, H; Kintner, D B; Shull, G E; Sun, D 2006. Inhibition of Na+/H+ exchanger isoform 1 attenuates mitochondrial cytochrome C release in cortical neurons following in vitro ischemia. Acta neurochirurgica. Supplement, 96 , 244-8

Pestov, Nikolay B; Korneenko, Tatyana V; Shakhparonov, Mikhail I; Shull, Gary E; Modyanov, Nikolai N 2006. Loss of acidification of anterior prostate fluids in Atp12a-null mutant mice indicates that nongastric H-K-ATPase functions as proton pump in vivo. American journal of physiology. Cell physiology, 291 2, C366-74

Wall, Susan M; Knepper, Mark A; Hassell, Kathryn A; Fischer, Michael P; Shodeinde, Adetola; Shin, Wonkyong; Pham, Truyen Derek; Meyer, Jamie W; Lorenz, John N; Beierwaltes, William H; Dietz, John R; Shull, Gary E; Kim, Young-Hee 2006. Hypotension in NKCC1 null mice: role of the kidneys. American journal of physiology. Renal physiology, 290 2, F409-16

Chen, Hai; Luo, Jing; Kintner, Douglas B; Shull, Gary E; Sun, Dandan 2005. Na(+)-dependent chloride transporter (NKCC1)-null mice exhibit less gray and white matter damage after focal cerebral ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 25 1, 54-66

Gawenis, Lara R; Greeb, Jeannette M; Prasad, Vikram; Grisham, Christina; Sanford, L Philip; Doetschman, Thomas; Andringa, Anastasia; Miller, Marian L; Shull, Gary E 2005. Impaired gastric acid secretion in mice with a targeted disruption of the NHE4 Na+/H+ exchanger. The Journal of biological chemistry, 280 13, 12781-9

Hunt, Deborah L; King, Bryan; Kahn, Dianna M; Yamoah, Ebenezer N; Shull, Gary E; Krubitzer, Leah 2005. Aberrant retinal projections in congenitally deaf mice: how are phenotypic characteristics specified in development and evolution? The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology, 287 1, 1051-66

Judd, Louise M; Andringa, Anastasia; Rubio, Carlos A; Spicer, Zachary; Shull, Gary E; Miller, Marian L 2005. Gastric achlorhydria in H/K-ATPase-deficient (Atp4a(-/-)) mice causes severe hyperplasia, mucocystic metaplasia and upregulation of growth factors. Journal of gastroenterology and hepatology, 20 8, 1266-78

Kintner, Douglas B; Look, Andy; Shull, Gary E; Sun, Dandan 2005. Stimulation of astrocyte Na+/H+ exchange activity in response to in vitro ischemia depends in part on activation of ERK1/2. American journal of physiology. Cell physiology, 289 4, C934-45

Kurnellas, Michael P; Nicot, Arnaud; Shull, Gary E; Elkabes, Stella 2005. Plasma membrane calcium ATPase deficiency causes neuronal pathology in the spinal cord: a potential mechanism for neurodegeneration in multiple sclerosis and spinal cord injury. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 19 2, 298-300

Luo, Jing; Chen, Hai; Kintner, Douglas B; Shull, Gary E; Sun, Dandan 2005. Decreased neuronal death in Na+/H+ exchanger isoform 1-null mice after in vitro and in vivo ischemia. The Journal of neuroscience : the official journal of the Society for Neuroscience, 25 49, 11256-68

Nicolet-Barousse, Laurence; Blanchard, Anne; Roux, Christian; Pietri, Laurence; Bloch-Faure, May; Kolta, Sami; Chappard, Christine; Geoffroy, Valérie; Morieux, Caroline; Jeunemaitre, Xavier; Shull, Gary E; Meneton, Pierre; Paillard, Michel; Houillier, Pascal; De Vernejoul, Marie-Christine 2005. Inactivation of the Na-Cl co-transporter (NCC) gene is associated with high BMD through both renal and bone mechanisms: analysis of patients with Gitelman syndrome and Ncc null mice. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 20 5, 799-808

Noonan, William T; Woo, Alison L; Nieman, Michelle L; Prasad, Vikram; Schultheis, Patrick J; Shull, Gary E; Lorenz, John N 2005. Blood pressure maintenance in NHE3-deficient mice with transgenic expression of NHE3 in small intestine. American journal of physiology. Regulatory, integrative and comparative physiology, 288 3, R685-91

Prasad, Vikram; Boivin, Gregory P; Miller, Marian L; Liu, Lynne H; Erwin, Christopher R; Warner, Brad W; Shull, Gary E 2005. Haploinsufficiency of Atp2a2, encoding the sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 Ca2+ pump, predisposes mice to squamous cell tumors via a novel mode of cancer susceptibility. Cancer research, 65 19, 8655-61

Ramos-Castañeda, Jose; Park, Young-nam; Liu, Ming; Hauser, Karin; Rudolph, Hans; Shull, Gary E; Jonkman, Marcel F; Mori, Kazutoshi; Ikeda, Shigaku; Ogawa, Hideoki; Arvan, Peter 2005. Deficiency of ATP2C1, a Golgi ion pump, induces secretory pathway defects in endoplasmic reticulum (ER)-associated degradation and sensitivity to ER stress. The Journal of biological chemistry, 280 10, 9467-73

Xu, Jie; Henriksnäs, Johanna; Barone, Sharon; Witte, David; Shull, Gary E; Forte, John G; Holm, Lena; Soleimani, Manoocher 2005. SLC26A9 is expressed in gastric surface epithelial cells, mediates Cl-/HCO3- exchange, and is inhibited by NH4+. American journal of physiology. Cell physiology, 289 2, C493-505

Xu, Yanfang; Zhang, Zhao; Timofeyev, Valeriy; Sharma, Dipika; Xu, Danyan; Tuteja, Dipika; Dong, Pei Hong; Ahmmed, Gias Uddin; Ji, Yong; Shull, Gary E; Periasamy, Muthu; Chiamvimonvat, Nipavan 2005. The effects of intracellular Ca2+ on cardiac K+ channel expression and activity: novel insights from genetically altered mice. The Journal of physiology, 562 Pt 3, 745-58

Bachmann, O; Riederer, B; Rossmann, H; Groos, S; Schultheis, P J; Shull, G E; Gregor, M; Manns, M P; Seidler, U 2004. The Na+/H+ exchanger isoform 2 is the predominant NHE isoform in murine colonic crypts and its lack causes NHE3 upregulation. American journal of physiology. Gastrointestinal and liver physiology, 287 1, G125-33

Bailey, Matthew A; Giebisch, Gerhard; Abbiati, Thecla; Aronson, Peter S; Gawenis, Lara R; Shull, Gary E; Wang, Tong 2004. NHE2-mediated bicarbonate reabsorption in the distal tubule of NHE3 null mice. The Journal of physiology, 561 Pt 3, 765-75

Chen, Jie; McLean, Paul A; Neel, Benjamin G; Okunade, Gbolahan; Shull, Gary E; Wortis, Henry H 2004. CD22 attenuates calcium signaling by potentiating plasma membrane calcium-ATPase activity. Nature immunology, 5 6, 651-7

Clarke, Lane L; Gawenis, Lara R; Bradford, Emily M; Judd, Louise M; Boyle, Kathryn T; Simpson, Janet E; Shull, Gary E; Tanabe, Hiroki; Ouellette, Andre J; Franklin, Craig L; Walker, Nancy M 2004. Abnormal Paneth cell granule dissolution and compromised resistance to bacterial colonization in the intestine of CF mice. American journal of physiology. Gastrointestinal and liver physiology, 286 6, G1050-8

Gawenis, Lara R; Hut, Hans; Bot, Alice G M; Shull, Gary E; de Jonge, Hugo R; Stien, Xavier; Miller, Marian L; Clarke, Lane L 2004. Electroneutral sodium absorption and electrogenic anion secretion across murine small intestine are regulated in parallel. American journal of physiology. Gastrointestinal and liver physiology, 287 6, G1140-9

Gawenis, Lara R; Ledoussal, Clara; Judd, Louise M; Prasad, Vikram; Alper, Seth L; Stuart-Tilley, Alan; Woo, Alison L; Grisham, Christina; Sanford, L Philip; Doetschman, Thomas; Miller, Marian L; Shull, Gary E 2004. Mice with a targeted disruption of the AE2 Cl-/HCO3- exchanger are achlorhydric. The Journal of biological chemistry, 279 29, 30531-9

Gekle, Michael; Völker, Katharina; Mildenberger, Sigrid; Freudinger, Ruth; Shull, Gary E; Wiemann, Martin 2004. NHE3 Na+/H+ exchanger supports proximal tubular protein reabsorption in vivo. American journal of physiology. Renal physiology, 287 3, F469-73

Good, David W; Watts, Bruns A; George, Thampi; Meyer, Jamie W; Shull, Gary E 2004. Transepithelial HCO3- absorption is defective in renal thick ascending limbs from Na+/H+ exchanger NHE1 null mutant mice. American journal of physiology. Renal physiology, 287 6, F1244-9

Kintner, Douglas B; Su, Gui; Lenart, Brett; Ballard, Andy J; Meyer, Jamie W; Ng, Leong L; Shull, Gary E; Sun, Dandan 2004. Increased tolerance to oxygen and glucose deprivation in astrocytes from Na(+)/H(+) exchanger isoform 1 null mice. American journal of physiology. Cell physiology, 287 1, C12-21

Lenart, Brett; Kintner, Douglas B; Shull, Gary E; Sun, Dandan 2004. Na-K-Cl cotransporter-mediated intracellular Na+ accumulation affects Ca2+ signaling in astrocytes in an in vitro ischemic model. The Journal of neuroscience : the official journal of the Society for Neuroscience, 24 43, 9585-97

Loffing, Johannes; Vallon, Volker; Loffing-Cueni, Dominique; Aregger, Fintan; Richter, Kerstin; Pietri, Laurence; Bloch-Faure, May; Hoenderop, Joost G J; Shull, Gary E; Meneton, Pierre; Kaissling, Brigitte 2004. Altered renal distal tubule structure and renal Na(+) and Ca(2+) handling in a mouse model for Gitelman's syndrome. Journal of the American Society of Nephrology : JASN, 15 9, 2276-88

Okunade, Gbolahan W; Miller, Marian L; Pyne, Gail J; Sutliff, Roy L; O'Connor, Kyle T; Neumann, Jonathan C; Andringa, Anastasia; Miller, Daniel A; Prasad, Vikram; Doetschman, Thomas; Paul, Richard J; Shull, Gary E 2004. Targeted ablation of plasma membrane Ca2+-ATPase (PMCA) 1 and 4 indicates a major housekeeping function for PMCA1 and a critical role in hyperactivated sperm motility and male fertility for PMCA4. The Journal of biological chemistry, 279 32, 33742-50

Prasad, Vikram; Okunade, Gbolahan W; Miller, Marian L; Shull, Gary E 2004. Phenotypes of SERCA and PMCA knockout mice. Biochemical and biophysical research communications, 322 4, 1192-203

Reinhardt, Timothy A; Lippolis, John D; Shull, Gary E; Horst, Ronald L 2004. Null mutation in the gene encoding plasma membrane Ca2+-ATPase isoform 2 impairs calcium transport into milk. The Journal of biological chemistry, 279 41, 42369-73

Schultheis, Patrick J; Hagen, Tamara T; O'Toole, Kate K; Tachibana, Akiko; Burke, Charles R; McGill, Diana L; Okunade, Gbolahan W; Shull, Gary E 2004. Characterization of the P5 subfamily of P-type transport ATPases in mice. Biochemical and biophysical research communications, 323 3, 731-8

Schultz, Jo El J; Glascock, Betty J; Witt, Sandra A; Nieman, Michelle L; Nattamai, Kalpana J; Liu, Lynne H; Lorenz, John N; Shull, Gary E; Kimball, Thomas R; Periasamy, Muthu 2004. Accelerated onset of heart failure in mice during pressure overload with chronically decreased SERCA2 calcium pump activity. American journal of physiology. Heart and circulatory physiology, 286 3, H1146-53

Amlal, Hassane; Ledoussal, Clara; Sheriff, Sulaiman; Shull, Gary E; Soleimani, Manoocher 2003. Downregulation of renal AQP2 water channel and NKCC2 in mice lacking the apical Na+-H+ exchanger NHE3. The Journal of physiology, 553 Pt 2, 511-22

Shull, Gary E; Okunade, Gbolahan; Liu, Lynne H; Kozel, Peter; Periasamy, Muthu; Lorenz, John N; Prasad, Vikram 2003. Physiological functions of plasma membrane and intracellular Ca2+ pumps revealed by analysis of null mutants. Annals of the New York Academy of Sciences, 986 , 453-60

Wang, Yigang; Meyer, Jamie W; Ashraf, Muhammad; Shull, Gary E 2003. Mice with a null mutation in the NHE1 Na+-H+ exchanger are resistant to cardiac ischemia-reperfusion injury. Circulation research, 93 8, 776-82

Woo, Alison L; Noonan, William T; Schultheis, Patrick J; Neumann, Jonathan C; Manning, Patrice A; Lorenz, John N; Shull, Gary E 2003. Renal function in NHE3-deficient mice with transgenic rescue of small intestinal absorptive defect. American journal of physiology. Renal physiology, 284 6, F1190-8

Xu, Jie; Barone, Sharon; Petrovic, Snezana; Wang, Zhaohui; Seidler, Ursula; Riederer, Brigitte; Ramaswamy, Krishnamurthy; Dudeja, Pradeep K; Shull, Gary E; Soleimani, Manoocher 2003. Identification of an apical Cl-/HCO3- exchanger in gastric surface mucous and duodenal villus cells. American journal of physiology. Gastrointestinal and liver physiology, 285 6, G1225-34

Arredouani, Abdelilah; Guiot, Yves; Jonas, Jean-Christophe; Liu, Lynne H; Nenquin, Myriam; Pertusa, José A; Rahier, Jacques; Rolland, Jean-François; Shull, Gary E; Stevens, Martine; Wuytack, Frank; Henquin, Jean-Claude; Gilon, Patrick 2002. SERCA3 ablation does not impair insulin secretion but suggests distinct roles of different sarcoendoplasmic reticulum Ca(2+) pumps for Ca(2+) homeostasis in pancreatic beta-cells. Diabetes, 51 11, 3245-53

Gawenis, Lara R; Stien, Xavier; Shull, Gary E; Schultheis, Patrick J; Woo, Alison L; Walker, Nancy M; Clarke, Lane L 2002. Intestinal NaCl transport in NHE2 and NHE3 knockout mice. American journal of physiology. Gastrointestinal and liver physiology, 282 5, G776-84

Kozel, Peter J; Davis, Rickie R; Krieg, Edward F; Shull, Gary E; Erway, Lawrence C 2002. Deficiency in plasma membrane calcium ATPase isoform 2 increases susceptibility to noise-induced hearing loss in mice. Hearing research, 164 1-2, 231-9

Lorenz, John N; Baird, Nancy R; Judd, Louise M; Noonan, William T; Andringa, Anastasia; Doetschman, Thomas; Manning, Patrice A; Liu, Lynne H; Miller, Marian L; Shull, Gary E 2002. Impaired renal NaCl absorption in mice lacking the ROMK potassium channel, a model for type II Bartter's syndrome. The Journal of biological chemistry, 277 40, 37871-80

Lu, Ming; Wang, Tong; Yan, Qingshang; Yang, Xinbo; Dong, Ke; Knepper, Mark A; Wang, WenHui; Giebisch, Gerhard; Shull, Gary E; Hebert, Steven C 2002. Absence of small conductance K+ channel (SK) activity in apical membranes of thick ascending limb and cortical collecting duct in ROMK (Bartter's) knockout mice. The Journal of biological chemistry, 277 40, 37881-7

Meyer, Jamie W; Flagella, Michael; Sutliff, Roy L; Lorenz, John N; Nieman, Michelle L; Weber, Craig S; Paul, Richard J; Shull, Gary E 2002. Decreased blood pressure and vascular smooth muscle tone in mice lacking basolateral Na(+)-K(+)-2Cl(-) cotransporter. American journal of physiology. Heart and circulatory physiology, 283 5, H1846-55

Miller, Marian L; Judd, Louise M; Van Driel, Ian R; Andringa, Anastasia; Flagella, Michael; Bell, Sheila M; Schultheis, Patrick J; Spicer, Zachary; Shull, Gary E 2002. The unique ultrastructure of secretory membranes in gastric parietal cells depends upon the presence of H+, K+ -ATPase. Cell and tissue research, 309 3, 369-80

Nehrke, Keith; Arreola, Jorge; Nguyen, Ha-Van; Pilato, Jodi; Richardson, Linda; Okunade, Gbolahan; Baggs, Raymond; Shull, Gary E; Melvin, James E 2002. Loss of hyperpolarization-activated Cl(-) current in salivary acinar cells from Clcn2 knockout mice. The Journal of biological chemistry, 277 26, 23604-11

Paul, R J; Shull, G E; Kranias, E G 2002. The sarcoplasmic reticulum and smooth muscle function: evidence from transgenic mice. Novartis Foundation symposium, 246 , 228-38; discussion 2

Petrovic, Snezana; Spicer, Zachary; Greeley, Tracey; Shull, Gary E; Soleimani, Manoocher 2002. Novel Schering and ouabain-insensitive potassium-dependent proton secretion in the mouse cortical collecting duct. American journal of physiology. Renal physiology, 282 1, F133-43

Petrovic, Snezana; Wang, Zhaohui; Ma, Liyun; Seidler, Ursula; Forte, John G; Shull, Gary E; Soleimani, Manoocher 2002. Colocalization of the apical Cl-/HCO3- exchanger PAT1 and gastric H-K-ATPase in stomach parietal cells. American journal of physiology. Gastrointestinal and liver physiology, 283 5, G1207-16

Shillingford, Jonathan M; Miyoshi, Keiko; Flagella, Michael; Shull, Gary E; Hennighausen, Lothar 2002. Mouse mammary epithelial cells express the Na-K-Cl cotransporter, NKCC1: characterization, localization, and involvement in ductal development and morphogenesis. Molecular endocrinology (Baltimore, Md.), 16 6, 1309-21

Su, Gui; Kintner, Douglas B; Flagella, Michael; Shull, Gary E; Sun, Dandan 2002. Astrocytes from Na(+)-K(+)-Cl(-) cotransporter-null mice exhibit absence of swelling and decrease in EAA release. American journal of physiology. Cell physiology, 282 5, C1147-60

Walker, Nancy M; Flagella, Michael; Gawenis, Lara R; Shull, Gary E; Clarke, Lane L 2002. An alternate pathway of cAMP-stimulated Cl secretion across the NKCC1-null murine duodenum. Gastroenterology, 123 2, 531-41

Woo, Alison L; Gildea, Lucy A; Tack, Leslie M; Miller, Marian L; Spicer, Zachary; Millhorn, David E; Finkelman, Fred D; Hassett, Daniel J; Shull, Gary E 2002. In vivo evidence for interferon-gamma-mediated homeostatic mechanisms in small intestine of the NHE3 Na+/H+ exchanger knockout model of congenital diarrhea. The Journal of biological chemistry, 277 50, 49036-46

Brooks, H L; Sorensen, A M; Terris, J; Schultheis, P J; Lorenz, J N; Shull, G E; Knepper, M A 2001. Profiling of renal tubule Na+ transporter abundances in NHE3 and NCC null mice using targeted proteomics. The Journal of physiology, 530 Pt 3, 359-66

Ledoussal, C; Lorenz, J N; Nieman, M L; Soleimani, M; Schultheis, P J; Shull, G E 2001. Renal salt wasting in mice lacking NHE3 Na+/H+ exchanger but not in mice lacking NHE2. American journal of physiology. Renal physiology, 281 4, F718-27

Ledoussal, C; Woo, A L; Miller, M L; Shull, G E 2001. Loss of the NHE2 Na(+)/H(+) exchanger has no apparent effect on diarrheal state of NHE3-deficient mice. American journal of physiology. Gastrointestinal and liver physiology, 281 6, G1385-96

Liu, L H; Boivin, G P; Prasad, V; Periasamy, M; Shull, G E 2001. Squamous cell tumors in mice heterozygous for a null allele of Atp2a2, encoding the sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 Ca2+ pump. The Journal of biological chemistry, 276 29, 26737-40

Mennone, A; Biemesderfer, D; Negoianu, D; Yang, C L; Abbiati, T; Schultheis, P J; Shull, G E; Aronson, P S; Boyer, J L 2001. Role of sodium/hydrogen exchanger isoform NHE3 in fluid secretion and absorption in mouse and rat cholangiocytes. American journal of physiology. Gastrointestinal and liver physiology, 280 2, G247-54

Park, K; Evans, R L; Watson, G E; Nehrke, K; Richardson, L; Bell, S M; Schultheis, P J; Hand, A R; Shull, G E; Melvin, J E 2001. Defective fluid secretion and NaCl absorption in the parotid glands of Na+/H+ exchanger-deficient mice. The Journal of biological chemistry, 276 29, 27042-50

Rossmann, H; Bachmann, O; Wang, Z; Shull, G E; Obermaier, B; Stuart-Tilley, A; Alper, S L; Seidler, U 2001. Differential expression and regulation of AE2 anion exchanger subtypes in rabbit parietal and mucous cells. The Journal of physiology, 534 Pt 3, 837-48

Spicer, Z; Clarke, L L; Gawenis, L R; Shull, G E 2001. Colonic H(+)-K(+)-ATPase in K(+) conservation and electrogenic Na(+) absorption during Na(+) restriction. American journal of physiology. Gastrointestinal and liver physiology, 281 6, G1369-77

Wang, T; Yang, C L; Abbiati, T; Shull, G E; Giebisch, G; Aronson, P S 2001. Essential role of NHE3 in facilitating formate-dependent NaCl absorption in the proximal tubule. American journal of physiology. Renal physiology, 281 2, F288-92

Zhao, X S; Shin, D M; Liu, L H; Shull, G E; Muallem, S 2001. Plasticity and adaptation of Ca2+ signaling and Ca2+-dependent exocytosis in SERCA2(+/-) mice. The EMBO journal, 20 11, 2680-9

Boivin, G P; Schultheis, P J; Shull, G E; Stemmermann, G N 2000. Variant form of diffuse corporal gastritis in NHE2 knockout mice. Comparative medicine, 50 5, 511-5

Choi, J Y; Shah, M; Lee, M G; Schultheis, P J; Shull, G E; Muallem, S; Baum, M 2000. Novel amiloride-sensitive sodium-dependent proton secretion in the mouse proximal convoluted tubule. The Journal of clinical investigation, 105 8, 1141-6

Evans, R L; Park, K; Turner, R J; Watson, G E; Nguyen, H V; Dennett, M R; Hand, A R; Flagella, M; Shull, G E; Melvin, J E 2000. Severe impairment of salivation in Na+/K+/2Cl- cotransporter (NKCC1)-deficient mice. The Journal of biological chemistry, 275 35, 26720-6

Ji, Y; Lalli, M J; Babu, G J; Xu, Y; Kirkpatrick, D L; Liu, L H; Chiamvimonvat, N; Walsh, R A; Shull, G E; Periasamy, M 2000. Disruption of a single copy of the SERCA2 gene results in altered Ca2+ homeostasis and cardiomyocyte function. The Journal of biological chemistry, 275 48, 38073-80

Lee, M G; Ahn, W; Choi, J Y; Luo, X; Seo, J T; Schultheis, P J; Shull, G E; Kim, K H; Muallem, S 2000. Na(+)-dependent transporters mediate HCO(3)(-) salvage across the luminal membrane of the main pancreatic duct. The Journal of clinical investigation, 105 11, 1651-8

Melvin, J E; Nguyen, H V; Evans, R L; Shull, G E 2000. What can transgenic and gene-targeted mouse models teach us about salivary gland physiology? Advances in dental research, 14 , 5-11

Nguyen, H V; Shull, G E; Melvin, J E 2000. Muscarinic receptor-induced acidification in sublingual mucous acinar cells: loss of pH recovery in Na+-H+ exchanger-1 deficient mice. The Journal of physiology, 523 Pt 1 , 139-46

Shull, G E 2000. Gene knockout studies of Ca2+-transporting ATPases. European journal of biochemistry / FEBS, 267 17, 5284-90

Shull, G E; Miller, M L; Schultheis, P J 2000. Lessons from genetically engineered animal models VIII. Absorption and secretion of ions in the gastrointestinal tract. American journal of physiology. Gastrointestinal and liver physiology, 278 2, G185-90

Spicer, Z; Miller, M L; Andringa, A; Riddle, T M; Duffy, J J; Doetschman, T; Shull, G E 2000. Stomachs of mice lacking the gastric H,K-ATPase alpha -subunit have achlorhydria, abnormal parietal cells, and ciliated metaplasia. The Journal of biological chemistry, 275 28, 21555-65

Szabó, E Z; Numata, M; Shull, G E; Orlowski, J 2000. Kinetic and pharmacological properties of human brain Na(+)/H(+) exchanger isoform 5 stably expressed in Chinese hamster ovary cells. The Journal of biological chemistry, 275 9, 6302-7

Wheat, V J; Shumaker, H; Burnham, C; Shull, G E; Yankaskas, J R; Soleimani, M 2000. CFTR induces the expression of DRA along with Cl(-)/HCO(3)(-) exchange activity in tracheal epithelial cells. American journal of physiology. Cell physiology, 279 1, C62-71

Baird, N R; Orlowski, J; Szabó, E Z; Zaun, H C; Schultheis, P J; Menon, A G; Shull, G E 1999. Molecular cloning, genomic organization, and functional expression of Na+/H+ exchanger isoform 5 (NHE5) from human brain. The Journal of biological chemistry, 274 7, 4377-82

Bell, S M; Schreiner, C M; Schultheis, P J; Miller, M L; Evans, R L; Vorhees, C V; Shull, G E; Scott, W J 1999. Targeted disruption of the murine Nhe1 locus induces ataxia, growth retardation, and seizures. The American journal of physiology, 276 4 Pt 1, C788-95

Evans, R L; Bell, S M; Schultheis, P J; Shull, G E; Melvin, J E 1999. Targeted disruption of the Nhe1 gene prevents muscarinic agonist-induced up-regulation of Na(+)/H(+) exchange in mouse parotid acinar cells. The Journal of biological chemistry, 274 41, 29025-30

Flagella, M; Clarke, L L; Miller, M L; Erway, L C; Giannella, R A; Andringa, A; Gawenis, L R; Kramer, J; Duffy, J J; Doetschman, T; Lorenz, J N; Yamoah, E N; Cardell, E L; Shull, G E 1999. Mice lacking the basolateral Na-K-2Cl cotransporter have impaired epithelial chloride secretion and are profoundly deaf. The Journal of biological chemistry, 274 38, 26946-55

Kao, J; Fortner, C N; Liu, L H; Shull, G E; Paul, R J 1999. Ablation of the SERCA3 gene alters epithelium-dependent relaxation in mouse tracheal smooth muscle. The American journal of physiology, 277 2 Pt 1, L264-70

Lorenz, J N; Schultheis, P J; Traynor, T; Shull, G E; Schnermann, J 1999. Micropuncture analysis of single-nephron function in NHE3-deficient mice. The American journal of physiology, 277 3 Pt 2, F447-53

Melvin, J E; Park, K; Richardson, L; Schultheis, P J; Shull, G E 1999. Mouse down-regulated in adenoma (DRA) is an intestinal Cl(-)/HCO(3)(-) exchanger and is up-regulated in colon of mice lacking the NHE3 Na(+)/H(+) exchanger. The Journal of biological chemistry, 274 32, 22855-61

Nakamura, S; Amlal, H; Schultheis, P J; Galla, J H; Shull, G E; Soleimani, M 1999. HCO-3 reabsorption in renal collecting duct of NHE-3-deficient mouse: a compensatory response. The American journal of physiology, 276 6 Pt 2, F914-21

Periasamy, M; Reed, T D; Liu, L H; Ji, Y; Loukianov, E; Paul, R J; Nieman, M L; Riddle, T; Duffy, J J; Doetschman, T; Lorenz, J N; Shull, G E 1999. Impaired cardiac performance in heterozygous mice with a null mutation in the sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 (SERCA2) gene. The Journal of biological chemistry, 274 4, 2556-62

Wang, T; Yang, C L; Abbiati, T; Schultheis, P J; Shull, G E; Giebisch, G; Aronson, P S 1999. Mechanism of proximal tubule bicarbonate absorption in NHE3 null mice. The American journal of physiology, 277 2 Pt 2, F298-302

Burnham, C E; Flagella, M; Wang, Z; Amlal, H; Shull, G E; Soleimani, M 1998. Cloning, renal distribution, and regulation of the rat Na+-HCO3- cotransporter. The American journal of physiology, 274 6 Pt 2, F1119-26

Kozel, P J; Friedman, R A; Erway, L C; Yamoah, E N; Liu, L H; Riddle, T; Duffy, J J; Doetschman, T; Miller, M L; Cardell, E L; Shull, G E 1998. Balance and hearing deficits in mice with a null mutation in the gene encoding plasma membrane Ca2+-ATPase isoform 2. The Journal of biological chemistry, 273 30, 18693-6

Lee, M G; Schultheis, P J; Yan, M; Shull, G E; Bookstein, C; Chang, E; Tse, M; Donowitz, M; Park, K; Muallem, S 1998. Membrane-limited expression and regulation of Na+-H+ exchanger isoforms by P2 receptors in the rat submandibular gland duct. The Journal of physiology, 513 ( Pt 2) , 341-57

Meneton, P; Schultheis, P J; Greeb, J; Nieman, M L; Liu, L H; Clarke, L L; Duffy, J J; Doetschman, T; Lorenz, J N; Shull, G E 1998. Increased sensitivity to K+ deprivation in colonic H,K-ATPase-deficient mice. The Journal of clinical investigation, 101 3, 536-42

Schultheis, P J; Clarke, L L; Meneton, P; Harline, M; Boivin, G P; Stemmermann, G; Duffy, J J; Doetschman, T; Miller, M L; Shull, G E 1998. Targeted disruption of the murine Na+/H+ exchanger isoform 2 gene causes reduced viability of gastric parietal cells and loss of net acid secretion. The Journal of clinical investigation, 101 6, 1243-53

Schultheis, P J; Clarke, L L; Meneton, P; Miller, M L; Soleimani, M; Gawenis, L R; Riddle, T M; Duffy, J J; Doetschman, T; Wang, T; Giebisch, G; Aronson, P S; Lorenz, J N; Shull, G E 1998. Renal and intestinal absorptive defects in mice lacking the NHE3 Na+/H+ exchanger. Nature genetics, 19 3, 282-5

Schultheis, P J; Lorenz, J N; Meneton, P; Nieman, M L; Riddle, T M; Flagella, M; Duffy, J J; Doetschman, T; Miller, M L; Shull, G E 1998. Phenotype resembling Gitelman's syndrome in mice lacking the apical Na+-Cl- cotransporter of the distal convoluted tubule. The Journal of biological chemistry, 273 44, 29150-5

Wang, Z; Rabb, H; Haq, M; Shull, G E; Soleimani, M 1998. A possible molecular basis of natriuresis during ischemic-reperfusion injury in the kidney. Journal of the American Society of Nephrology : JASN, 9 4, 605-13

Beitner-Johnson, D; Shull, G E; Dedman, J R; Millhorn, D E 1997. Regulation of gene expression by hypoxia: a molecular approach. Respiration physiology, 110 2-3, 87-97

Burnham, C E; Amlal, H; Wang, Z; Shull, G E; Soleimani, M 1997. Cloning and functional expression of a human kidney Na+:HCO3- cotransporter. The Journal of biological chemistry, 272 31, 19111-4

Liu, L H; Paul, R J; Sutliff, R L; Miller, M L; Lorenz, J N; Pun, R Y; Duffy, J J; Doetschman, T; Kimura, Y; MacLennan, D H; Hoying, J B; Shull, G E 1997. Defective endothelium-dependent relaxation of vascular smooth muscle and endothelial cell Ca2+ signaling in mice lacking sarco(endo)plasmic reticulum Ca2+-ATPase isoform 3. The Journal of biological chemistry, 272 48, 30538-45

Wang, Z; Rabb, H; Craig, T; Burnham, C; Shull, G E; Soleimani, M 1997. Ischemic-reperfusion injury in the kidney: overexpression of colonic H+-K+-ATPase and suppression of NHE-3. Kidney international, 51 4, 1106-15

Cougnon, M; Planelles, G; Crowson, M S; Shull, G E; Rossier, B C; Jaisser, F 1996. The rat distal colon P-ATPase alpha subunit encodes a ouabain-sensitive H+, K+-ATPase. The Journal of biological chemistry, 271 13, 7277-80

Pathak, B G; Shaughnessy, J D; Meneton, P; Greeb, J; Shull, G E; Jenkins, N A; Copeland, N G 1996. Mouse chromosomal location of three epithelial sodium channel subunit genes and an apical sodium chloride cotransporter gene. Genomics, 33 1, 124-7

Pathak, B G; Shull, G E; Jenkins, N A; Copeland, N G 1996. Mouse chromosomal location of four Na/H exchanger isoform genes. Genomics, 31 2, 261-3

Wang, Z; Schultheis, P J; Shull, G E 1996. Three N-terminal variants of the AE2 Cl-/HCO3- exchanger are encoded by mRNAs transcribed from alternative promoters. The Journal of biological chemistry, 271 13, 7835-43

Burk, S E; Menon, A G; Shull, G E 1995. Analysis of the 5' end of the rat plasma membrane Ca(2+)-ATPase isoform 3 gene and identification of extensive trinucleotide repeat sequences in the 5' untranslated region. Biochimica et biophysica acta, 1240 2, 119-24

Keeton, T P; Shull, G E 1995. Primary structure of rat plasma membrane Ca(2+)-ATPase isoform 4 and analysis of alternative splicing patterns at splice site A. The Biochemical journal, 306 ( Pt 3) , 779-85

Linn, S C; Askew, G R; Menon, A G; Shull, G E 1995. Conservation of an AE3 Cl-/HCO3- exchanger cardiac-specific exon and promoter region and AE3 mRNA expression patterns in murine and human hearts. Circulation research, 76 4, 584-91

Su, Y R; Klanke, C A; Houseal, T W; Linn, S C; Burk, S E; Varvil, T S; Otterud, B E; Shull, G E; Leppert, M F; Menon, A G 1994. Molecular cloning and physical and genetic mapping of the human anion exchanger isoform 3 (SLC2C) gene to chromosome 2q36. Genomics, 22 3, 605-9

Keeton, T P; Burk, S E; Shull, G E 1993. Alternative splicing of exons encoding the calmodulin-binding domains and C termini of plasma membrane Ca(2+)-ATPase isoforms 1, 2, 3, and 4. The Journal of biological chemistry, 268 4, 2740-8

Kudrycki, K E; Shull, G E 1993. Rat kidney band 3 Cl-/HCO3- exchanger mRNA is transcribed from an alternative promoter. The American journal of physiology, 264 3 Pt 2, F540-7

Wang, Z; Orlowski, J; Shull, G E 1993. Primary structure and functional expression of a novel gastrointestinal isoform of the rat Na/H exchanger. The Journal of biological chemistry, 268 16, 11925-8

Yu, F H; Shull, G E; Orlowski, J 1993. Functional properties of the rat Na/H exchanger NHE-2 isoform expressed in Na/H exchanger-deficient Chinese hamster ovary cells. The Journal of biological chemistry, 268 34, 25536-41

Burk, S E; Shull, G E 1992. Structure of the rat plasma membrane Ca(2+)-ATPase isoform 3 gene and characterization of alternative splicing and transcription products. Skeletal muscle-specific splicing results in a plasma membrane Ca(2+)-ATPase with a novel calmodulin-binding domain. The Journal of biological chemistry, 267 27, 19683-90

Crowson, M S; Shull, G E 1992. Isolation and characterization of a cDNA encoding the putative distal colon H+,K(+)-ATPase. Similarity of deduced amino acid sequence to gastric H+,K(+)-ATPase and Na+,K(+)-ATPase and mRNA expression in distal colon, kidney, and uterus. The Journal of biological chemistry, 267 19, 13740-8

Fiedler, M A; Nemecz, Z K; Shull, G E 1992. Cloning and sequence analysis of rat cystic fibrosis transmembrane conductance regulator. The American journal of physiology, 262 6 Pt 1, L779-84

Gunteski-Hamblin, A M; Clarke, D M; Shull, G E 1992. Molecular cloning and tissue distribution of alternatively spliced mRNAs encoding possible mammalian homologues of the yeast secretory pathway calcium pump. Biochemistry, 31 33, 7600-8

Linn, S C; Kudrycki, K E; Shull, G E 1992. The predicted translation product of a cardiac AE3 mRNA contains an N terminus distinct from that of the brain AE3 Cl-/HCO3- exchanger. Cloning of a cardiac AE3 cDNA, organization of the AE3 gene, and identification of an alternative transcription initiation site. The Journal of biological chemistry, 267 11, 7927-35

Lytton, J; Westlin, M; Burk, S E; Shull, G E; MacLennan, D H 1992. Functional comparisons between isoforms of the sarcoplasmic or endoplasmic reticulum family of calcium pumps. The Journal of biological chemistry, 267 20, 14483-9

Orlowski, J; Kandasamy, R A; Shull, G E 1992. Molecular cloning of putative members of the Na/H exchanger gene family. cDNA cloning, deduced amino acid sequence, and mRNA tissue expression of the rat Na/H exchanger NHE-1 and two structurally related proteins. The Journal of biological chemistry, 267 13, 9331-9

Shull, G E; Clarke, D M; Gunteski-Hamblin, A M 1992. cDNA cloning of possible mammalian homologs of the yeast secretory pathway Ca(2+)-transporting ATPase. Annals of the New York Academy of Sciences, 671 , 70-80; discussion 81

Newman, P R; Shull, G E 1991. Rat gastric H,K-ATPase beta-subunit gene: intron/exon organization, identification of multiple transcription initiation sites, and analysis of the 5'-flanking region. Genomics, 11 2, 252-62

Kudrycki, K E; Newman, P R; Shull, G E 1990. cDNA cloning and tissue distribution of mRNAs for two proteins that are related to the band 3 Cl-/HCO3- exchanger. The Journal of biological chemistry, 265 1, 462-71

Newman, P R; Greeb, J; Keeton, T P; Reyes, A A; Shull, G E 1990. Structure of the human gastric H,K-ATPase gene and comparison of the 5'-flanking sequences of the human and rat genes. DNA and cell biology, 9 10, 749-62

Shull, G E 1990. cDNA cloning of the beta-subunit of the rat gastric H,K-ATPase. The Journal of biological chemistry, 265 21, 12123-6

Burk, S E; Lytton, J; MacLennan, D H; Shull, G E 1989. cDNA cloning, functional expression, and mRNA tissue distribution of a third organellar Ca2+ pump. The Journal of biological chemistry, 264 31, 18561-8

Greeb, J; Shull, G E 1989. Molecular cloning of a third isoform of the calmodulin-sensitive plasma membrane Ca2+-transporting ATPase that is expressed predominantly in brain and skeletal muscle. The Journal of biological chemistry, 264 31, 18569-76

Koch, W J; Hui, A; Shull, G E; Ellinor, P; Schwartz, A 1989. Characterization of cDNA clones encoding two putative isoforms of the alpha 1 subunit of the dihydropyridine-sensitive voltage-dependent calcium channel isolated from rat brain and rat aorta. FEBS letters, 250 2, 386-8

Kudrycki, K E; Shull, G E 1989. Primary structure of the rat kidney band 3 anion exchange protein deduced from a cDNA. The Journal of biological chemistry, 264 14, 8185-92

Dickey, L F; Wang, Y H; Shull, G E; Wortman, I A; Theil, E C 1988. The importance of the 3'-untranslated region in the translational control of ferritin mRNA. The Journal of biological chemistry, 263 7, 3071-4

Gunteski-Hamblin, A M; Greeb, J; Shull, G E 1988. A novel Ca2+ pump expressed in brain, kidney, and stomach is encoded by an alternative transcript of the slow-twitch muscle sarcoplasmic reticulum Ca-ATPase gene. Identification of cDNAs encoding Ca2+ and other cation-transporting ATPases using an oligonucleotide probe derived from the ATP-binding site. The Journal of biological chemistry, 263 29, 15032-40

Shull, G E; Greeb, J 1988. Molecular cloning of two isoforms of the plasma membrane Ca2+-transporting ATPase from rat brain. Structural and functional domains exhibit similarity to Na+,K+- and other cation transport ATPases. The Journal of biological chemistry, 263 18, 8646-57

Shull, G E; Young, R M; Greeb, J; Lingrel, J B 1988. Overview: amino acid sequences of the alpha and beta subunits of the Na,K-ATPase. Progress in clinical and biological research, 268A , 3-18

Shull, G E; Lingrel, J B 1987. Isolation and characterization of a cDNA for the catalytic subunit of the (Na+ + K+)-ATPase. Society of General Physiologists series, 41 , 301-21

Small, S J; Shull, G E; Santoni, M J; Akeson, R 1987. Identification of a cDNA clone that contains the complete coding sequence for a 140-kD rat NCAM polypeptide. The Journal of cell biology, 105 5, 2335-45

Young, R M; Shull, G E; Lingrel, J B 1987. Multiple mRNAs from rat kidney and brain encode a single Na+,K+-ATPase beta subunit protein. The Journal of biological chemistry, 262 10, 4905-10

Shull, G E; Greeb, J; Lingrel, J B 1986. Molecular cloning of three distinct forms of the Na+,K+-ATPase alpha-subunit from rat brain. Biochemistry, 25 25, 8125-32

Shull, G E; Lingrel, J B 1986. Molecular cloning of the rat stomach (H+ + K+)-ATPase. The Journal of biological chemistry, 261 36, 16788-91

Shull, G E 1984. Differential inhibition of protein synthesis: a possible biochemical mechanism of thalidomide teratogenesis. Journal of theoretical biology, 110 3, 461-86

Shull, G E; Theil, E C 1983. Regulation of ferritin mRNA: a possible gene-sparing phenomenon. Induction of ferritin synthesis by iron in liver as well as red cells combines high translational efficiency with increased utilization of preformed ferritin mRNA. The Journal of biological chemistry, 258 13, 7921-3

Shull, G E; Theil, E C 1982. Translational control of ferritin synthesis by iron in embryonic reticulocytes of the bullfrog. The Journal of biological chemistry, 257 23, 14187-91

Shull, G E; Lane, L K; Lingrel, J B . Amino-acid sequence of the beta-subunit of the (Na+ + K+)ATPase deduced from a cDNA. Nature, 321 6068, 429-31

Shull, G E; Schwartz, A; Lingrel, J B . Amino-acid sequence of the catalytic subunit of the (Na+ + K+)ATPase deduced from a complementary DNA. Nature, 316 6030, 691-5

Shull, Gary E; Miller, Marian L; Prasad, Vikram . Secretory pathway stress responses as possible mechanisms of disease involving Golgi Ca2+ pump dysfunction. BioFactors (Oxford, England), 37 3, 150-8