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Department of

Molecular Genetics, Biochemistry & Microbiology

Photo of  Catharine Saelinger, PhD

Catharine Saelinger, PhD

Professor of Molecular Genetics, Biochemistry & Microbiology

Education/Credentials
  • Ph.D.: University of Cincinnati
  • M.S.: University of Cincinnati
  • A.B.: Smith College

Contact Information
  • Office 3260 Medical Sciences Building
  • 231 Albert Sabin Way
  • Cincinnati, Ohio 45267-0524
  • Office (513)558-0072
  • Email saelincb@ucmail.uc.edu

Peer Reviewed Publications

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Le Poole, I C; Boissy, R E; Sarangarajan, R; Chen, J; Forristal, J J; Sheth, P; Westerhof, W; Babcock, G; Das, P K; Saelinger, C B 2000. PIG3V, an immortalized human vitiligo melanocyte cell line, expresses dilated endoplasmic reticulum. In vitro cellular & developmental biology. Animal, 36 5, 309-19

FitzGerald, D J; Fryling, C M; Zdanovsky, A; Saelinger, C B; Kounnas, M; Winkles, J A; Strickland, D; Leppla, S 1995. Pseudomonas exotoxin-mediated selection yields cells with altered expression of low-density lipoprotein receptor-related protein. The Journal of cell biology, 129 6, 1533-41

Mucci, D; Forristal, J; Strickland, D; Morris, R; Fitzgerald, D; Saelinger, C B 1995. Level of receptor-associated protein moderates cellular susceptibility to pseudomonas exotoxin A. Infection and immunity, 63 8, 2912-8

Fitzgerald, D J; Fryling, C M; Zdanovsky, A; Saelinger, C B; Kounnas, M; Strickland, D K; Leppla, S 1994. Selection of Pseudomonas exotoxin-resistant cells with altered expression of alpha 2MR/LRP. Annals of the New York Academy of Sciences, 737 , 138-44

Saelinger, C B; Morris, R E 1994. Uptake and processing of toxins by mammalian cells. Methods in enzymology, 235 , 705-17

Kounnas, M Z; Morris, R E; Thompson, M R; FitzGerald, D J; Strickland, D K; Saelinger, C B 1992. The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds and internalizes Pseudomonas exotoxin A. The Journal of biological chemistry, 267 18, 12420-3

Morris, R E; Ciraolo, G M; Saelinger, C B 1992. Validation of the biotinyl ligand-avidin-gold technique. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 40 5, 711-21

Forristal, J J; Thompson, M R; Morris, R E; Saelinger, C B 1991. Mouse liver contains a Pseudomonas aeruginosa exotoxin A-binding protein. Infection and immunity, 59 9, 2880-4

Morris, R E; Ciraolo, G M; Saelinger, C B 1991. Gold enhancement of gold-labeled probes: gold-intensified staining technique (GIST). The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 39 11, 1585-91

Thompson, M R; Forristal, J; Kauffmann, P; Madden, T; Kozak, K; Morris, R E; Saelinger, C B 1991. Isolation and characterization of Pseudomonas aeruginosa exotoxin A binding glycoprotein from mouse LM cells. The Journal of biological chemistry, 266 4, 2390-6

Morris, R E; Saelinger, C B 1990. Visualization of intracellular trafficking of proteins. Methods in enzymology, 184 , 379-88

Kozak, K J; Saelinger, C B 1988. Preparation of Pseudomonas exotoxin A. Methods in enzymology, 165 , 147-52

Saelinger, C B 1988. Use of exotoxin A to inhibit protein synthesis. Methods in enzymology, 165 , 226-31

Saelinger, C B; Morris, R E 1987. Intracellular trafficking of Pseudomonas exotoxin A. Antibiotics and chemotherapy, 39 , 149-59

Morris, R E; Saelinger, C B 1986. Problems in the production and use of 5 nm avidin-gold colloids. Journal of microscopy, 143 Pt 2, 171-6

Morris, R E; Saelinger, C B 1986. Reduced temperature alters Pseudomonas exotoxin A entry into the mouse LM cell. Infection and immunity, 52 2, 445-53

Morris, R E; Gerstein, A S; Bonventre, P F; Saelinger, C B 1985. Receptor-mediated entry of diphtheria toxin into monkey kidney (Vero) cells: electron microscopic evaluation. Infection and immunity, 50 3, 721-7

Morris, R E; Saelinger, C B 1985. Route of pseudomonas and diphtheria toxin entry into mammalian cells: basis for susceptibility to toxin. Survey and synthesis of pathology research, 4 1, 34-43

Saelinger, C B; Morris, R E; Foertsch, G 1985. Trafficking of Pseudomonas exotoxin A in mammalian cells. European journal of clinical microbiology, 4 2, 170-4

Manhart, M D; Morris, R E; Bonventre, P F; Leppla, S; Saelinger, C B 1984. Evidence for pseudomonas exotoxin A receptors on plasma membrane of toxin-sensitive lm fibroblasts. Infection and immunity, 45 3, 596-603

Morris, R E; Saelinger, C B 1984. Visualization of intracellular trafficking: use of biotinylated ligands in conjunction with avidin-gold colloids. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 32 1, 124-8

Morris, R E; Manhart, M D; Saelinger, C B 1983. Receptor-mediated entry of Pseudomonas toxin: methylamine blocks clustering step. Infection and immunity, 40 2, 806-11

Morris, R E; Saelinger, C B 1983. Diphtheria toxin does not enter resistant cells by receptor-mediated endocytosis. Infection and immunity, 42 2, 812-7

Fitzgerald, D; Morris, R E; Saelinger, C B 1982. Essential role of calcium in cellular internalization of Pseudomonas toxin. Infection and immunity, 35 2, 715-20

Morris, R E; Saelinger, C B 1982. Combined use of immunoferritin and immunocolloidal gold for the simultaneous demonstration of two antigens by immuno-electron microscopy. Stain technology, 57 4, 225-37

Morris, R E; Saelinger, C B 1982. A simple reliable method for producing electron dense markers of uniform size for use in immunoelectron microscopy. Journal of immunological methods, 49 3, 237-46

Weber, B; Nickol, M M; Jagger, K S; Saelinger, C B 1982. Interaction of pseudomonas exoproducts with phagocytic cells. Canadian journal of microbiology, 28 6, 679-85

FitzGerald, D; Morris, R E; Saelinger, C B 1980. Receptor-mediated internalization of Pseudomonas toxin by mouse fibroblasts. Cell, 21 3, 867-73

Jagger, K; Nickol, M M; Saelinger, C B 1980. Resistance of exotoxin A to purified Pseudomonas proteolytic enzymes. Infection and immunity, 28 3, 746-52

Snell, K; Holder, I A; Leppla, S A; Saelinger, C B 1978. Role of exotoxin and protease as possible virulence factors in experimental infections with Pseudomonas aeruginosa. Infection and immunity, 19 3, 839-45

Saelinger, C B; Snell, K; Holder, I A 1977. Experimental studies on the pathogenesis of infections due to Pseudomonas aeruginosa: direct evidence for toxin production during Pseudomonas infection of burned skin tissues. The Journal of infectious diseases, 136 4, 555-61

Saelinger, C B; Bonventre, P F; Ivins, B; Straus, D 1976. Uptake of diphtheria toxin and its fragment A moiety by mammalian cells in culture. Infection and immunity, 14 3, 742-51

Bonventre, P F; Saelinger, C B; Ivins, B; Woscinski, C; Amorini, M 1975. Interaction of cultured mammalian cells with [125I] diphtheria toxin. Infection and immunity, 11 4, 675-84

Ivins, B; Saelinger, C B; Bonventre, P F; Woscinski, C 1975. Chemical modulation of diphtheria toxin action on cultured mammalian cells. Infection and immunity, 11 4, 665-74

Saelinger, C B; Higginbotham, R D 1974. Hypersensitivity responses to bee venom and the mellitin. International archives of allergy and applied immunology, 46 1, 28-37

Bonventre, P F; Saelinger, C B; Imhoff, J G 1973. Studies on the effect of diphtheria toxin on protein synthesis in mice. Journal of medical microbiology, 6 2, 169-76

Saelinger, C B; Imhoff, J G; Bonventre, P F 1973. Studies on the mode of action of diphtheria toxin. VI. Inhibition of protein synthesis induced by local infection with toxingenic Corynebacterium diphtheriae. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 142 1, 41-5

Bonventre, P F; Saelinger, C B 1972. Inhibition of protein synthesis after intravenous or intramuscular challenge with diphtheria toxin. Infection and immunity, 6 3, 418-21

FitzGerald, D; Morris, R E; Saelinger, C B . Inhibition of the activity of pseudomonas toxin by methylamine. Reviews of infectious diseases, 5 Suppl 5 , S985-91