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Department of

Molecular Genetics, Biochemistry & Microbiology

Photo of  Jerry Lingrel, PhD

Jerry Lingrel, PhD

Professor of Molecular Genetics, Biochemistry & Microbiology

Education/Credentials
  • Bachelor's Degree: Otterbein College
  • Doctoral Degree: The Ohio State University

Research/Clinical Interests

Pattern of gene expression during development of several tissue, including lung, kidney, heart, T cells, adipocytes and endothelial cells.

Contact Information
  • CVC 2936
  • 231 Albert Sabin Way
  • Cincinnati, Ohio 45267-0521
  • Office 513-558-5326
  • Fax 513-558-1885
  • Email lingrejb@uc.edu

Peer Reviewed Publications

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Blaustein, Mordecai P; Chen, Ling; Hamlyn, John M; Leenen, Frans H H; Lingrel, Jerry B; Wier, W Gil; Zhang, Jin 2016. Pivotal role of ?2 Na(+) pumps and their high affinity ouabain binding site in cardiovascular health and disease. The Journal of physiology, ,

Xiong, Ye; Lingrel, Jerry B; Wüthrich, Marcel; Klein, Bruce S; Vasudevan, Neelakantan T; Jain, Mukesh K; George, Mariam; Deepe, George S 2016. Transcription Factor KLF2 in Dendritic Cells Downregulates Th2 Programming via the HIF-1?/Jagged2/Notch Axis. mBio, 7 3,

DiFranco, Marino; Hakimjavadi, Hesamedin; Lingrel, Jerry B; Heiny, Judith A 2015. Na,K-ATPase ?2 activity in mammalian skeletal muscle T-tubules is acutely stimulated by extracellular K. The Journal of general physiology, 146 4, 281-94

Manoharan, Palanikumar; Radzyukevich, Tatiana L; Hakim Javadi, Hesamedin; Stiner, Cory A; Landero Figueroa, Julio A; Lingrel, Jerry B; Heiny, Judith A 2015. Phospholemman is not required for the acute stimulation of Na+-K+-ATPase ?2-activity during skeletal muscle fatigue. American journal of physiology. Cell physiology, 309 12, C813-22

Shattock, Michael J; Ottolia, Michela; Bers, Donald M; Blaustein, Mordecai P; Boguslavskyi, Andrii; Bossuyt, Julie; Bridge, John H B; Chen-Izu, Ye; Clancy, Colleen E; Edwards, Andrew; Goldhaber, Joshua; Kaplan, Jack; Lingrel, Jerry B; Pavlovic, Davor; Philipson, Kenneth; Sipido, Karin R; Xie, Zi-Jian 2015. Na+/Ca2+ exchange and Na+/K+-ATPase in the heart. The Journal of physiology, 593 6, 1361-82

Gallardo, Gilbert; Barowski, Jessica; Ravits, John; Siddique, Teepu; Lingrel, Jerry B; Robertson, Janice; Steen, Hanno; Bonni, Azad 2014. An ?2-Na/K ATPase/?-adducin complex in astrocytes triggers non-cell autonomous neurodegeneration. Nature neuroscience, 17 12, 1710-9

Manoharan, Palanikumar; Basford, Joshua E; Pilcher-Roberts, Robyn; Neumann, Jonathan; Hui, David Y; Lingrel, Jerry B 2014. Reduced levels of microRNAs miR-124a and miR-150 are associated with increased proinflammatory mediator expression in Krüppel-like factor 2 (KLF2)-deficient macrophages. The Journal of biological chemistry, 289 45, 31638-46

Kaphzan, Hanoch; Buffington, Shelly A; Ramaraj, Akila B; Lingrel, Jerry B; Rasband, Matthew N; Santini, Emanuela; Klann, Eric 2013. Genetic reduction of the ?1 subunit of Na/K-ATPase corrects multiple hippocampal phenotypes in Angelman syndrome. Cell reports, 4 3, 405-12

Rindler, Tara N; Lasko, Valerie M; Nieman, Michelle L; Okada, Motoi; Lorenz, John N; Lingrel, Jerry B 2013. Knockout of the Na,K-ATPase ?2-isoform in cardiac myocytes delays pressure overload-induced cardiac dysfunction. American journal of physiology. Heart and circulatory physiology, 304 8, H1147-58

Despa, Sanda; Lingrel, Jerry B; Bers, Donald M 2012. Na(+)/K)+)-ATPase ?2-isoform preferentially modulates Ca2(+) transients and sarcoplasmic reticulum Ca2(+) release in cardiac myocytes. Cardiovascular research, 95 4, 480-6

Lingrel, Jerry B; Pilcher-Roberts, Robyn; Basford, Joshua E; Manoharan, Palanikumar; Neumann, Jon; Konaniah, Eddy S; Srinivasan, Ramprasad; Bogdanov, Vladimir Y; Hui, David Y 2012. Myeloid-specific Krüppel-like factor 2 inactivation increases macrophage and neutrophil adhesion and promotes atherosclerosis. Circulation research, 110 10, 1294-302

Liu, Changxuan; Bai, Yan; Chen, Yiliang; Wang, Yu; Sottejeau, Yoann; Liu, Lijun; Li, Xiaomei; Lingrel, Jerry B; Malhotra, Deepak; Cooper, Christopher J; Shapiro, Joseph I; Xie, Zi-jian; Tian, Jiang 2012. Reduction of Na/K-ATPase potentiates marinobufagenin-induced cardiac dysfunction and myocyte apoptosis. The Journal of biological chemistry, 287 20, 16390-8

Lorenz, John N; Oshiro, Naomi; Loreaux, Elizabeth L; Lingrel, Jerry B 2012. DOCA-salt hypertension does not require the ouabain-sensitive binding site of the ?2 Na,K-ATPase. American journal of hypertension, 25 4, 421-9

Mahabeleshwar, Ganapati H; Qureshi, Muhammad Awais; Takami, Yoichi; Sharma, Nikunj; Lingrel, Jerry B; Jain, Mukesh K 2012. A myeloid hypoxia-inducible factor 1?-Krüppel-like factor 2 pathway regulates gram-positive endotoxin-mediated sepsis. The Journal of biological chemistry, 287 2, 1448-57

Radzyukevich, Tatiana L; Neumann, Jonathon C; Rindler, Tara N; Oshiro, Naomi; Goldhamer, David J; Lingrel, Jerry B; Heiny, Judith A 2012. Tissue-Specific Role of the Na,K-ATPase ?2 Isozyme in Skeletal Muscle. The Journal of biological chemistry, ,

Chatterjee, Tapan K; Idelman, Gila; Blanco, Victor; Blomkalns, Andra L; Piegore, Mark G; Weintraub, Daniel S; Kumar, Santosh; Rajsheker, Srinivas; Manka, David; Rudich, Steven M; Tang, Yaoliang; Hui, David Y; Bassel-Duby, Rhonda; Olson, Eric N; Lingrel, Jerry B; Ho, Shuk-Mei; Weintraub, Neal L 2011. Histone deacetylase 9 is a negative regulator of adipogenic differentiation. The Journal of biological chemistry, 286 31, 27836-47

DeAndrade, Mark P; Yokoi, Fumiaki; van Groen, Thomas; Lingrel, Jerry B; Li, Yuqing 2011. Characterization of Atp1a3 mutant mice as a model of rapid-onset dystonia with parkinsonism. Behavioural brain research, 216 2, 659-65

Lorenz, John N; Lasko, Valerie M; Nieman, Michelle L; Damhoff, Thomas; Prasad, Vikram; Beierwaltes, William H; Lingrel, Jerry B 2011. Renovascular hypertension using a modified two-kidney, one-clip approach in mice is not dependent on the ?1 or ?2 Na-K-ATPase ouabain-binding site. American journal of physiology. Renal physiology, 301 3, F615-21

Mahabeleshwar, Ganapati H; Kawanami, Daiji; Sharma, Nikunj; Takami, Yoichi; Zhou, Guangjin; Shi, Hong; Nayak, Lalitha; Jeyaraj, Darwin; Grealy, Robert; White, Mary; McManus, Ross; Ryan, Thomas; Leahy, Patrick; Lin, Zhiyong; Haldar, Saptarsi M; Atkins, G Brandon; Wong, Hector R; Lingrel, Jerry B; Jain, Mukesh K 2011. The myeloid transcription factor KLF2 regulates the host response to polymicrobial infection and endotoxic shock. Immunity, 34 5, 715-28

Pei, Liming; Leblanc, Mathias; Barish, Grant; Atkins, Annette; Nofsinger, Russell; Whyte, Jamie; Gold, David; He, Mingxiao; Kawamura, Kazuko; Li, Hai-Ri; Downes, Michael; Yu, Ruth T; Powell, Henry C; Lingrel, Jerry B; Evans, Ronald M 2011. Thyroid hormone receptor repression is linked to type I pneumocyte-associated respiratory distress syndrome. Nature medicine, 17 11, 1466-72

Rindler, Tara N; Dostanic, Iva; Lasko, Valerie M; Nieman, Michelle L; Neumann, Jonathan C; Lorenz, John N; Lingrel, Jerry B 2011. Knockout of the Na,K-ATPase ??-isoform in the cardiovascular system does not alter basal blood pressure but prevents ACTH-induced hypertension. American journal of physiology. Heart and circulatory physiology, 301 4, H1396-404

Schaefer, Tori L; Lingrel, Jerry B; Moseley, Amy E; Vorhees, Charles V; Williams, Michael T 2011. Targeted mutations in the Na,K-ATPase ? 2 isoform confer ouabain resistance and result in abnormal behavior in mice. Synapse (New York, N.Y.), 65 6, 520-31

Van Huysse, James W; Dostanic, Iva; Lingrel, Jerry B; Hou, Xiaohong; Wu, Hengwei 2011. Hypertension from chronic central sodium chloride in mice is mediated by the ouabain-binding site on the Na,K-ATPase ??-isoform. American journal of physiology. Heart and circulatory physiology, 301 5, H2147-53

Wansapura, Arshani N; Lasko, Valerie M; Lingrel, Jerry B; Lorenz, John N 2011. Mice expressing ouabain-sensitive ?1-Na,K-ATPase have increased susceptibility to pressure overload-induced cardiac hypertrophy. American journal of physiology. Heart and circulatory physiology, 300 1, H347-55

Khan, Sohaib; Lingrel, Jerry B 2010. Thematic minireview series on nuclear receptors in biology and diseases. The Journal of biological chemistry, 285 50, 38741-2

Lingrel, Jerry B 2010. The physiological significance of the cardiotonic steroid/ouabain-binding site of the Na,K-ATPase. Annual review of physiology, 72 , 395-412

Oshiro, Naomi; Dostanic-Larson, Iva; Neumann, Jon C; Lingrel, Jerry B 2010. The ouabain-binding site of the ?2 isoform of Na,K-ATPase plays a role in blood pressure regulation during pregnancy. American journal of hypertension, 23 12, 1279-85

Blaustein, Mordecai P; Zhang, Jin; Chen, Ling; Song, Hong; Raina, Hema; Kinsey, Stephen P; Izuka, Michelle; Iwamoto, Takahiro; Kotlikoff, Michael I; Lingrel, Jerry B; Philipson, Kenneth D; Wier, W Gil; Hamlyn, John M 2009. The pump, the exchanger, and endogenous ouabain: signaling mechanisms that link salt retention to hypertension. Hypertension, 53 2, 291-8

Bossuyt, Julie; Despa, Sanda; Han, Fei; Hou, Zhanjia; Robia, Seth L; Lingrel, Jerry B; Bers, Donald M 2009. Isoform specificity of the Na/K-ATPase association and regulation by phospholemman. The Journal of biological chemistry, 284 39, 26749-57

Chen, Yiliang; Cai, Ting; Wang, Haojie; Li, Zhichuan; Loreaux, Elizabeth; Lingrel, Jerry B; Xie, Zijian 2009. Regulation of intracellular cholesterol distribution by Na/K-ATPase. The Journal of biological chemistry, 284 22, 14881-90

Han, Fei; Tucker, Amy L; Lingrel, Jerry B; Despa, Sanda; Bers, Donald M 2009. Extracellular potassium dependence of the Na+-K+-ATPase in cardiac myocytes: isoform specificity and effect of phospholemman. American journal of physiology. Cell physiology, 297 3, C699-705

Hou, Xiaohong; Theriault, Steven F; Dostanic-Larson, Iva; Moseley, Amy E; Lingrel, Jerry B; Wu, Hengwei; Dean, Stephanie; Van Huysse, James W 2009. Enhanced pressor response to increased CSF sodium concentration and to central ANG I in heterozygous alpha2 Na+ -K+ -ATPase knockout mice. American journal of physiology. Regulatory, integrative and comparative physiology, 296 5, R1427-38

Radzyukevich, T L; Lingrel, J B; Heiny, J A 2009. The cardiac glycoside binding site on the Na,K-ATPase alpha2 isoform plays a role in the dynamic regulation of active transport in skeletal muscle. Proceedings of the National Academy of Sciences of the United States of America, 106 8, 2565-70

Wansapura, Arshani N; Lasko, Valerie; Xie, Zijian; Fedorova, Olga V; Bagrov, Alexei Y; Lingrel, Jerry B; Lorenz, John N 2009. Marinobufagenin enhances cardiac contractility in mice with ouabain-sensitive alpha1 Na+-K+-ATPase. American journal of physiology. Heart and circulatory physiology, 296 6, H1833-9

Loreaux, Elizabeth L; Kaul, Baksho; Lorenz, John N; Lingrel, Jerry B 2008. Ouabain-Sensitive alpha1 Na,K-ATPase enhances natriuretic response to saline load. Journal of the American Society of Nephrology : JASN, 19 10, 1947-54

Lorenz, John N; Loreaux, Elizabeth L; Dostanic-Larson, Iva; Lasko, Valerie; Schnetzer, J Renee; Paul, Richard J; Lingrel, Jerry B 2008. ACTH-induced hypertension is dependent on the ouabain-binding site of the alpha2-Na+-K+-ATPase subunit. American journal of physiology. Heart and circulatory physiology, 295 1, H273-80

Wu, Jinghai; Bohanan, Cynthia S; Neumann, Jon C; Lingrel, Jerry B 2008. KLF2 transcription factor modulates blood vessel maturation through smooth muscle cell migration. The Journal of biological chemistry, 283 7, 3942-50

Basu, Priyadarshi; Lung, Tina K; Lemsaddek, Wafaa; Sargent, Thanh Giang; Williams, David C; Basu, Mohua; Redmond, Latasha C; Lingrel, Jerry B; Haar, Jack L; Lloyd, Joyce A 2007. EKLF and KLF2 have compensatory roles in embryonic beta-globin gene expression and primitive erythropoiesis. Blood, 110 9, 3417-25

Lingrel, Jerry B 2007. How I became a biochemist. IUBMB life, 59 10, 685-7

Lingrel, Jerry B; Williams, Michael T; Vorhees, Charles V; Moseley, Amy E 2007. Na,K-ATPase and the role of alpha isoforms in behavior. Journal of bioenergetics and biomembranes, 39 5-6, 385-9

Moseley, Amy E; Williams, Michael T; Schaefer, Tori L; Bohanan, Cynthia S; Neumann, Jon C; Behbehani, Michael M; Vorhees, Charles V; Lingrel, Jerry B 2007. Deficiency in Na,K-ATPase alpha isoform genes alters spatial learning, motor activity, and anxiety in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience, 27 3, 616-26

Carlson, Corey M; Endrizzi, Bart T; Wu, Jinghai; Ding, Xiaojie; Weinreich, Michael A; Walsh, Elizabeth R; Wani, Maqsood A; Lingrel, Jerry B; Hogquist, Kristin A; Jameson, Stephen C 2006. Kruppel-like factor 2 regulates thymocyte and T-cell migration. Nature, 442 7100, 299-302

Dostanic-Larson, Iva; Lorenz, John N; Van Huysse, James W; Neumann, Jon C; Moseley, Amy E; Lingrel, Jerry B 2006. Physiological role of the alpha1- and alpha2-isoforms of the Na+-K+-ATPase and biological significance of their cardiac glycoside binding site. American journal of physiology. Regulatory, integrative and comparative physiology, 290 3, R524-8

Huddleson, Justin P; Ahmad, Nisar; Lingrel, Jerry B 2006. Up-regulation of the KLF2 transcription factor by fluid shear stress requires nucleolin. The Journal of biological chemistry, 281 22, 15121-8

Lorenz, John N; Dostanic-Larson, Iva; Shull, Gary E; Lingrel, Jerry B 2006. Ouabain inhibits tubuloglomerular feedback in mutant mice with ouabain-sensitive alpha1 Na,K-ATPase. Journal of the American Society of Nephrology : JASN, 17 9, 2457-63

Ahmad, Nisar; Lingrel, Jerry B 2005. Kruppel-like factor 2 transcriptional regulation involves heterogeneous nuclear ribonucleoproteins and acetyltransferases. Biochemistry, 44 16, 6276-85

Basu, Priyadarshi; Morris, Pamela E; Haar, Jack L; Wani, Maqsood A; Lingrel, Jerry B; Gaensler, Karin M L; Lloyd, Joyce A 2005. KLF2 is essential for primitive erythropoiesis and regulates the human and murine embryonic beta-like globin genes in vivo. Blood, 106 7, 2566-71

Chen, Ceshi; Sun, Xiaodong; Guo, Peng; Dong, Xue-Yuan; Sethi, Pooja; Cheng, Xiaohong; Zhou, Jun; Ling, Junxiu; Simons, Jonathan W; Lingrel, Jerry B; Dong, Jin-Tang 2005. Human Kruppel-like factor 5 is a target of the E3 ubiquitin ligase WWP1 for proteolysis in epithelial cells. The Journal of biological chemistry, 280 50, 41553-61

Dostanic, Iva; Paul, Richard J; Lorenz, John N; Theriault, Steven; Van Huysse, James W; Lingrel, Jerry B 2005. The alpha2-isoform of Na-K-ATPase mediates ouabain-induced hypertension in mice and increased vascular contractility in vitro. American journal of physiology. Heart and circulatory physiology, 288 2, H477-85

Dostanic-Larson, Iva; Van Huysse, James W; Lorenz, John N; Lingrel, Jerry B 2005. The highly conserved cardiac glycoside binding site of Na,K-ATPase plays a role in blood pressure regulation. Proceedings of the National Academy of Sciences of the United States of America, 102 44, 15845-50

Huddleson, Justin P; Ahmad, Nisar; Srinivasan, Seetha; Lingrel, Jerry B 2005. Induction of KLF2 by fluid shear stress requires a novel promoter element activated by a phosphatidylinositol 3-kinase-dependent chromatin-remodeling pathway. The Journal of biological chemistry, 280 24, 23371-9

Looney, Mark R; Sartori, Claudio; Chakraborty, Santanu; James, Paul F; Lingrel, Jerry B; Matthay, Michael A 2005. Decreased expression of both the alpha1- and alpha2-subunits of the Na-K-ATPase reduces maximal alveolar epithelial fluid clearance. American journal of physiology. Lung cellular and molecular physiology, 289 1, L104-10

Moseley, Amy E; Huddleson, Justin P; Bohanan, Cynthia S; James, Paul F; Lorenz, John N; Aronow, Bruce J; Lingrel, Jerry B 2005. Genetic profiling reveals global changes in multiple biological pathways in the hearts of Na, K-ATPase alpha 1 isoform haploinsufficient mice. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 15 1-4, 145-58

Wu, Jinghai; Lingrel, Jerry B 2005. Krüppel-like factor 2, a novel immediate-early transcriptional factor, regulates IL-2 expression in T lymphocyte activation. Journal of immunology (Baltimore, Md. : 1950), 175 5, 3060-6

Wu, Jinghai; Srinivasan, Seetha V; Neumann, Jon C; Lingrel, Jerry B 2005. The KLF2 transcription factor does not affect the formation of preadipocytes but inhibits their differentiation into adipocytes. Biochemistry, 44 33, 11098-105

Yamamoto, Taku; Su, Zhi; Moseley, Amy E; Kadono, Toshie; Zhang, John; Cougnon, Marc; Li, Fenghua; Lingrel, Jerry B; Barry, William H 2005. Relative abundance of alpha2 Na(+) pump isoform influences Na(+)-Ca(2+) exchanger currents and Ca(2+) transients in mouse ventricular myocytes. Journal of molecular and cellular cardiology, 39 1, 113-20

Zhang, Jin; Lee, Moo Yeol; Cavalli, Maurizio; Chen, Ling; Berra-Romani, Roberto; Balke, C William; Bianchi, Giuseppe; Ferrari, Patrizia; Hamlyn, John M; Iwamoto, Takahiro; Lingrel, Jerry B; Matteson, Donald R; Wier, W Gil; Blaustein, Mordecai P 2005. Sodium pump alpha2 subunits control myogenic tone and blood pressure in mice. The Journal of physiology, 569 Pt 1, 243-56

Barcroft, L C; Moseley, A E; Lingrel, J B; Watson, A J 2004. Deletion of the Na/K-ATPase alpha1-subunit gene (Atp1a1) does not prevent cavitation of the preimplantation mouse embryo. Mechanisms of development, 121 5, 417-26

Dostanic, Iva; Schultz, Jo El J; Lorenz, John N; Lingrel, Jerry B 2004. The alpha 1 isoform of Na,K-ATPase regulates cardiac contractility and functionally interacts and co-localizes with the Na/Ca exchanger in heart. The Journal of biological chemistry, 279 52, 54053-61

Hartford, April K; Messer, Miranda L; Moseley, Amy E; Lingrel, Jerry B; Delamere, Nicholas A 2004. Na,K-ATPase alpha 2 inhibition alters calcium responses in optic nerve astrocytes. Glia, 45 3, 229-37

Huddleson, Justin P; Srinivasan, Seetha; Ahmad, Nisar; Lingrel, Jerry B 2004. Fluid shear stress induces endothelial KLF2 gene expression through a defined promoter region. Biological chemistry, 385 8, 723-9

Moseley, Amy E; Cougnon, Marc H; Grupp, Ingrid L; El Schultz, Jo; Lingrel, Jerry B 2004. Attenuation of cardiac contractility in Na,K-ATPase alpha1 isoform-deficient hearts under reduced calcium conditions. Journal of molecular and cellular cardiology, 37 5, 913-9

Radzyukevich, Tatiana L; Moseley, Amy E; Shelly, Daniel A; Redden, Gregory A; Behbehani, Michael M; Lingrel, Jerry B; Paul, Richard J; Heiny, Judith A 2004. The Na(+)-K(+)-ATPase alpha2-subunit isoform modulates contractility in the perinatal mouse diaphragm. American journal of physiology. Cell physiology, 287 5, C1300-10

Wu, Jinghai; Lingrel, Jerry B 2004. KLF2 inhibits Jurkat T leukemia cell growth via upregulation of cyclin-dependent kinase inhibitor p21WAF1/CIP1. Oncogene, 23 49, 8088-96

Zhang, Xiaoling; Srinivasan, Seetha V; Lingrel, Jerry B 2004. WWP1-dependent ubiquitination and degradation of the lung Krüppel-like factor, KLF2. Biochemical and biophysical research communications, 316 1, 139-48

Dostanic, Iva; Lorenz, John N; Schultz, Jo El J; Grupp, Ingrid L; Neumann, Jonathan C; Wani, Maqsood A; Lingrel, Jerry B 2003. The alpha2 isoform of Na,K-ATPase mediates ouabain-induced cardiac inotropy in mice. The Journal of biological chemistry, 278 52, 53026-34

Golovina, Vera A; Song, Hong; James, Paul F; Lingrel, Jerry B; Blaustein, Mordecai P 2003. Na+ pump alpha 2-subunit expression modulates Ca2+ signaling. American journal of physiology. Cell physiology, 284 2, C475-86

Lin, Yong; Ryan, Jennifer; Lewis, Joseph; Wani, Maqsood A; Lingrel, Jerry B; Liu, Zheng-Gang 2003. TRAF2 exerts its antiapoptotic effect by regulating the expression of Krüppel-like factor LKLF. Molecular and cellular biology, 23 16, 5849-56

Moseley, Amy E; Lieske, Steve P; Wetzel, Randall K; James, Paul F; He, Suiwen; Shelly, Daniel A; Paul, Richard J; Boivin, Gregory P; Witte, David P; Ramirez, Jan Marino; Sweadner, Kathleen J; Lingrel, Jerry B 2003. The Na,K-ATPase alpha 2 isoform is expressed in neurons, and its absence disrupts neuronal activity in newborn mice. The Journal of biological chemistry, 278 7, 5317-24

Cougnon, Marc H; Moseley, Amy E; Radzyukevich, Tatiana L; Lingrel, Jerry B; Heiny, Judith A 2002. Na,K-ATPase alpha- and beta-isoform expression in developing skeletal muscles: alpha(2) correlates with t-tubule formation. Pflügers Archiv : European journal of physiology, 445 1, 123-31

Woo, Alison L; James, Paul F; Lingrel, Jerry B 2002. Roles of the Na,K-ATPase alpha4 isoform and the Na+/H+ exchanger in sperm motility. Molecular reproduction and development, 62 3, 348-56

Conkright, M D; Wani, M A; Lingrel, J B 2001. Lung Krüppel-like factor contains an autoinhibitory domain that regulates its transcriptional activation by binding WWP1, an E3 ubiquitin ligase. The Journal of biological chemistry, 276 31, 29299-306

He, S; Shelly, D A; Moseley, A E; James, P F; James, J H; Paul, R J; Lingrel, J B 2001. The alpha(1)- and alpha(2)-isoforms of Na-K-ATPase play different roles in skeletal muscle contractility. American journal of physiology. Regulatory, integrative and comparative physiology, 281 3, R917-25

Lingrel, J B 2001. Transport ATPase trafficking minireview series. The Journal of biological chemistry, 276 32, 29611

McGraw, D W; Fukuda, N; James, P F; Forbes, S L; Woo, A L; Lingrel, J B; Witte, D P; Matthay, M A; Liggett, S B 2001. Targeted transgenic expression of beta(2)-adrenergic receptors to type II cells increases alveolar fluid clearance. American journal of physiology. Lung cellular and molecular physiology, 281 4, L895-903

Müller-Ehmsen, J; Juvvadi, P; Thompson, C B; Tumyan, L; Croyle, M; Lingrel, J B; Schwinger, R H; McDonough, A A; Farley, R A 2001. Ouabain and substrate affinities of human Na(+)-K(+)-ATPase alpha(1)beta(1), alpha(2)beta(1), and alpha(3)beta(1) when expressed separately in yeast cells. American journal of physiology. Cell physiology, 281 4, C1355-64

Schrick, J J; Lingrel, J B 2001. cDNA cloning, mapping and expression of the mouse propionyl CoA carboxylase beta (pccb), the gene for human type II propionic acidaemia. Gene, 264 1, 147-52

Anderson, K P; Crable, S C; Lingrel, J B 2000. The GATA-E box-GATA motif in the EKLF promoter is required for in vivo expression. Blood, 95 5, 1652-5

Peluffo, R D; Argüello, J M; Lingrel, J B; Berlin, J R 2000. Electrogenic sodium-sodium exchange carried out by Na,K-ATPase containing the amino acid substitution Glu779Ala. The Journal of general physiology, 116 1, 61-73

Woo, A L; James, P F; Lingrel, J B 2000. Sperm motility is dependent on a unique isoform of the Na,K-ATPase. The Journal of biological chemistry, 275 27, 20693-9

Argüello, J M; Whitis, J; Cheung, M C; Lingrel, J B 1999. Functional role of oxygen-containing residues in the fifth transmembrane segment of the Na,K-ATPase alpha subunit. Archives of biochemistry and biophysics, 364 2, 254-63

Argüello, J M; Whitis, J; Lingrel, J B 1999. Alanine scanning mutagenesis of oxygen-containing amino acids in the transmembrane region of the Na,K-ATPase. Archives of biochemistry and biophysics, 367 2, 341-7

Conkright, M D; Wani, M A; Anderson, K P; Lingrel, J B 1999. A gene encoding an intestinal-enriched member of the Krüppel-like factor family expressed in intestinal epithelial cells. Nucleic acids research, 27 5, 1263-70

James, P F; Grupp, I L; Grupp, G; Woo, A L; Askew, G R; Croyle, M L; Walsh, R A; Lingrel, J B 1999. Identification of a specific role for the Na,K-ATPase alpha 2 isoform as a regulator of calcium in the heart. Molecular cell, 3 5, 555-63

Schrick, J J; Hughes, M J; Anderson, K P; Croyle, M L; Lingrel, J B 1999. Characterization of the lung Krüppel-like transcription factor gene and upstream regulatory elements. Gene, 236 1, 185-95

Wani, M A; Conkright, M D; Jeffries, S; Hughes, M J; Lingrel, J B 1999. cDNA isolation, genomic structure, regulation, and chromosomal localization of human lung Kruppel-like factor. Genomics, 60 1, 78-86

Wani, M A; Wert, S E; Lingrel, J B 1999. Lung Kruppel-like factor, a zinc finger transcription factor, is essential for normal lung development. The Journal of biological chemistry, 274 30, 21180-5

Woo, A L; James, P F; Lingrel, J B 1999. Characterization of the fourth alpha isoform of the Na,K-ATPase. The Journal of membrane biology, 169 1, 39-44

Anderson, K P; Crable, S C; Lingrel, J B 1998. Multiple proteins binding to a GATA-E box-GATA motif regulate the erythroid Krüppel-like factor (EKLF) gene. The Journal of biological chemistry, 273 23, 14347-54

Blostein, R; Daly, S E; Boxenbaum, N; Lane, L K; Arguello, J M; Lingrel, J B; Karlish, S J; Caplan, M J; Dunbar, L 1998. Conformational alterations resulting from mutations in cytoplasmic domains of the alpha subunit of the Na,K-ATPase. Acta physiologica Scandinavica. Supplementum, 643 , 275-81

Derfoul, A; Robertson, N M; Lingrel, J B; Hall, D J; Litwack, G 1998. Regulation of the human Na/K-ATPase beta1 gene promoter by mineralocorticoid and glucocorticoid receptors. The Journal of biological chemistry, 273 33, 20702-11

Lingrel, J B; Croyle, M L; Woo, A L; Argüello, J M 1998. Ligand binding sites of Na,K-ATPase. Acta physiologica Scandinavica. Supplementum, 643 , 69-77

Wani, M A; Means, R T; Lingrel, J B 1998. Loss of LKLF function results in embryonic lethality in mice. Transgenic research, 7 4, 229-38

Blostein, R; Wilczynska, A; Karlish, S J; Argüello, J M; Lingrel, J B 1997. Evidence that Ser775 in the alpha subunit of the Na,K-ATPase is a residue in the cation binding pocket. The Journal of biological chemistry, 272 40, 24987-93

Croyle, M L; Woo, A L; Lingrel, J B 1997. Extensive random mutagenesis analysis of the Na+/K+-ATPase alpha subunit identifies known and previously unidentified amino acid residues that alter ouabain sensitivity--implications for ouabain binding. European journal of biochemistry / FEBS, 248 2, 488-95

Lingrel, J B; Argüello, J M; Van Huysse, J; Kuntzweiler, T A 1997. Cation and cardiac glycoside binding sites of the Na,K-ATPase. Annals of the New York Academy of Sciences, 834 , 194-206

Peluffo, R D; Lingrel, J B; Argüello, J M; Berlin, J R 1997. Changes to Na,K-ATPase alpha-subunit E779 separate the structural basis for VM and ion dependence of Na,K-pump current. Annals of the New York Academy of Sciences, 834 , 339-42

Tepperman, K; Millette, L A; Johnson, C L; Jewell-Motz, E A; Lingrel, J B; Wallick, E T 1997. Mutational analysis of Glu-327 of Na(+)-K(+)-ATPase reveals stimulation of 86Rb+ uptake by external K+. The American journal of physiology, 273 6 Pt 1, C2065-79

Anderson, K P; Kern, C B; Crable, S C; Neumann, J C; Lingrel, J B 1996. Analysis of developmental switching in transgenic mice with 5' and 3' deletions in the human beta globin gene. Transgenic research, 5 4, 245-55

Argüello, J M; Peluffo, R D; Feng, J; Lingrel, J B; Berlin, J R 1996. Substitution of glutamic 779 with alanine in the Na,K-ATPase alpha subunit removes voltage dependence of ion transport. The Journal of biological chemistry, 271 40, 24610-6

Kuntzweiler, T A; Argüello, J M; Lingrel, J B 1996. Asp804 and Asp808 in the transmembrane domain of the Na,K-ATPase alpha subunit are cation coordinating residues. The Journal of biological chemistry, 271 47, 29682-7

O'Brien, W J; Lingrel, J B; Fischer, J E; Hasselgren, P O 1996. Sepsis increases skeletal muscle sodium, potassium-adenosinetriphosphatase activity without affecting messenger RNA or protein levels. Journal of the American College of Surgeons, 183 5, 471-9

Palasis, M; Kuntzweiler, T A; Argüello, J M; Lingrel, J B 1996. Ouabain interactions with the H5-H6 hairpin of the Na,K-ATPase reveal a possible inhibition mechanism via the cation binding domain. The Journal of biological chemistry, 271 24, 14176-82

Van Huysse, J W; Kuntzweiler, T A; Lingrel, J B 1996. Critical effects on catalytic function produced by amino acid substitutions at Asp804 and Asp808 of the alpha1 isoform of Na,K-ATPase. FEBS letters, 389 2, 179-85

Anderson, K P; Kern, C B; Crable, S C; Lingrel, J B 1995. Isolation of a gene encoding a functional zinc finger protein homologous to erythroid Krüppel-like factor: identification of a new multigene family. Molecular and cellular biology, 15 11, 5957-65

Argüello, J M; Lingrel, J B 1995. Substitutions of serine 775 in the alpha subunit of the Na,K-ATPase selectively disrupt K+ high affinity activation without affecting Na+ interaction. The Journal of biological chemistry, 270 39, 22764-71

Crump, R G; Askew, G R; Wert, S E; Lingrel, J B; Joiner, C H 1995. In situ localization of sodium-potassium ATPase mRNA in developing mouse lung epithelium. The American journal of physiology, 269 3 Pt 1, L299-308

Feng, J; Lingrel, J B 1995. Functional consequences of substitutions of the carboxyl residue glutamate 779 of the Na,K-ATPase. Cellular & molecular biology research, 41 1, 29-37

Johnson, C L; Kuntzweiler, T A; Lingrel, J B; Johnson, C G; Wallick, E T 1995. Glutamic acid 327 in the sheep alpha 1 isoform of Na+,K(+)-ATPase is a pivotal residue for cation-induced conformational changes. The Biochemical journal, 309 ( Pt 1) , 187-94

Johnson, C L; Schultheis, P J; Lingrel, J B; Johnson, C G; Wallick, E T 1995. Comparison of the effects of potassium on ouabain binding to native and site-directed mutants of Na,K-ATPase. Archives of biochemistry and biophysics, 317 1, 133-41

Kuntzweiler, T A; Wallick, E T; Johnson, C L; Lingrel, J B 1995. Amino acid replacement of Asp369 in the sheep alpha 1 isoform eliminates ATP and phosphate stimulation of [3H]ouabain binding to the Na+, K(+)-ATPase without altering the cation binding properties of the enzyme. The Journal of biological chemistry, 270 27, 16206-12

Kuntzweiler, T A; Wallick, E T; Johnson, C L; Lingrel, J B 1995. Glutamic acid 327 in the sheep alpha 1 isoform of Na+,K(+)-ATPase stabilizes a K(+)-induced conformational change. The Journal of biological chemistry, 270 7, 2993-3000

Askew, G R; Lingrel, J B 1994. Identification of an amino acid substitution in human alpha 1 Na,K-ATPase which confers differentially reduced affinity for two related cardiac glycosides. The Journal of biological chemistry, 269 39, 24120-6

Feng, J; Lingrel, J B 1994. Analysis of amino acid residues in the H5-H6 transmembrane and extracellular domains of Na,K-ATPase alpha subunit identifies threonine 797 as a determinant of ouabain sensitivity. Biochemistry, 33 14, 4218-24

Lingrel, J B; Kuntzweiler, T 1994. Na+,K(+)-ATPase. The Journal of biological chemistry, 269 31, 19659-62

Lingrel, J B; Van Huysse, J; O'Brien, W; Jewell-Motz, E; Askew, R; Schultheis, P 1994. Structure-function studies of the Na,K-ATPase. Kidney international. Supplement, 44 , S32-9

Lloyd, J A; Case, S S; Ponce, E; Lingrel, J B 1994. Positive transcriptional regulation of the human gamma-globin gene. Gamma PE is a novel nuclear factor with multiple binding sites near the gene. The Journal of biological chemistry, 269 30, 19385-93

Munzer, J S; Daly, S E; Jewell-Motz, E A; Lingrel, J B; Blostein, R 1994. Tissue- and isoform-specific kinetic behavior of the Na,K-ATPase. The Journal of biological chemistry, 269 24, 16668-76

O'Brien, W J; Lingrel, J B; Wallick, E T 1994. Ouabain binding kinetics of the rat alpha two and alpha three isoforms of the sodium-potassium adenosine triphosphate. Archives of biochemistry and biophysics, 310 1, 32-9

Pathak, B G; Neumann, J C; Croyle, M L; Lingrel, J B 1994. The presence of both negative and positive elements in the 5'-flanking sequence of the rat Na,K-ATPase alpha 3 subunit gene are required for brain expression in transgenic mice. Nucleic acids research, 22 22, 4748-55

Shamraj, O I; Lingrel, J B 1994. A putative fourth Na+,K(+)-ATPase alpha-subunit gene is expressed in testis. Proceedings of the National Academy of Sciences of the United States of America, 91 26, 12952-6

Anderson, K P; Lloyd, J A; Ponce, E; Crable, S C; Neumann, J C; Lingrel, J B 1993. Regulated expression of the human beta globin gene in transgenic mice requires an upstream globin or nonglobin promoter. Molecular biology of the cell, 4 10, 1077-85

Askew, G R; Doetschman, T; Lingrel, J B 1993. Site-directed point mutations in embryonic stem cells: a gene-targeting tag-and-exchange strategy. Molecular and cellular biology, 13 7, 4115-24

Boissy, R E; Boissy, Y L; Krakowsky, J M; Lamoreux, M L; Lingrel, J B; Nordlund, J J 1993. Ocular pathology in mice with a transgenic insertion at the microphthalmia locus. Journal of submicroscopic cytology and pathology, 25 3, 319-32

Feng, J; Orlowski, J; Lingrel, J B 1993. Identification of a functional thyroid hormone response element in the upstream flanking region of the human Na,K-ATPase beta 1 gene. Nucleic acids research, 21 11, 2619-26

Giannella, R A; Orlowski, J; Jump, M L; Lingrel, J B 1993. Na(+)-K(+)-ATPase gene expression in rat intestine and Caco-2 cells: response to thyroid hormone. The American journal of physiology, 265 4 Pt 1, G775-82

Hughes, M J; Lingrel, J B; Krakowsky, J M; Anderson, K P 1993. A helix-loop-helix transcription factor-like gene is located at the mi locus. The Journal of biological chemistry, 268 28, 20687-90

Jewell-Motz, E A; Lingrel, J B 1993. Site-directed mutagenesis of the Na,K-ATPase: consequences of substitutions of negatively-charged amino acids localized in the transmembrane domains. Biochemistry, 32 49, 13523-30

Krakowsky, J M; Boissy, R E; Neumann, J C; Lingrel, J B 1993. A DNA insertional mutation results in microphthalmia in transgenic mice. Transgenic research, 2 1, 14-20

O'Brien, W J; Wallick, E T; Lingrel, J B 1993. Amino acid residues of the Na,K-ATPase involved in ouabain sensitivity do not bind the sugar moiety of cardiac glycosides. The Journal of biological chemistry, 268 11, 7707-12

Schultheis, P J; Lingrel, J B 1993. Substitution of transmembrane residues with hydrogen-bonding potential in the alpha subunit of Na,K-ATPase reveals alterations in ouabain sensitivity. Biochemistry, 32 2, 544-50

Schultheis, P J; Wallick, E T; Lingrel, J B 1993. Kinetic analysis of ouabain binding to native and mutated forms of Na,K-ATPase and identification of a new region involved in cardiac glycoside interactions. The Journal of biological chemistry, 268 30, 22686-94

Shamraj, O I; Grupp, I L; Grupp, G; Melvin, D; Gradoux, N; Kremers, W; Lingrel, J B; De Pover, A 1993. Characterisation of Na/K-ATPase, its isoforms, and the inotropic response to ouabain in isolated failing human hearts. Cardiovascular research, 27 12, 2229-37

Van Huysse, J W; Jewell, E A; Lingrel, J B 1993. Site-directed mutagenesis of a predicted cation binding site of Na, K-ATPase. Biochemistry, 32 3, 819-26

Van Huysse, J W; Lingrel, J B 1993. Nonpolar amino acid substitutions of potential cation binding residues glu-955 and glu-956 of the rat alpha 1 isoform of Na+, K(+)-ATPase. Cellular & molecular biology research, 39 5, 497-507

Jewell, E A; Lingrel, J B 1992. Chimeric rat Na,K-ATPase alpha 1/alpha 3* isoforms. Analysis of the structural basis for differences in Na+ requirements in the alpha 1 and alpha 3* isoforms. Annals of the New York Academy of Sciences, 671 , 120-32; discussion 1

Jewell, E A; Shamraj, O I; Lingrel, J B 1992. Isoforms of the alpha subunit of Na,K-ATPase and their significance. Acta physiologica Scandinavica. Supplementum, 607 , 161-9

Lingrel, J B 1992. Na,K-ATPase: isoform structure, function, and expression. Journal of bioenergetics and biomembranes, 24 3, 263-70

Lloyd, J A; Krakowsky, J M; Crable, S C; Lingrel, J B 1992. Human gamma- to beta-globin gene switching using a mini construct in transgenic mice. Molecular and cellular biology, 12 4, 1561-7

Shull, M M; Hassenbein, D; Loggie, J; Daniels, S; King, A; Burton, T; Lingrel, J B 1992. Discordant segregation of Na+,K(+)-adenosine triphosphatase alleles and essential hypertension. Journal of hypertension, 10 9, 1005-10

Jewell, E A; Lingrel, J B 1991. Comparison of the substrate dependence properties of the rat Na,K-ATPase alpha 1, alpha 2, and alpha 3 isoforms expressed in HeLa cells. The Journal of biological chemistry, 266 25, 16925-30

Lingrel, J B; Orlowski, J; Price, E M; Pathak, B G 1991. Regulation of the alpha-subunit genes of the Na,K-ATPase and determinants of cardiac glycoside sensitivity. Society of General Physiologists series, 46 , 1-16

Mann, E A; Croyle, M L; Lingrel, J B 1991. Identification of sequences mediating interleukin-6 induction of a rat T kininogen gene. The Journal of biological chemistry, 266 25, 16931-4

Mann, E A; Lingrel, J B 1991. Developmental and tissue-specific expression of rat T-kininogen. Biochemical and biophysical research communications, 174 2, 417-23

Ponce, E; Lloyd, J A; Pierani, A; Roeder, R G; Lingrel, J B 1991. Transcription factor OTF-1 interacts with two distinct DNA elements in the A gamma-globin gene promoter. Biochemistry, 30 11, 2961-7

Shamraj, O I; Melvin, D; Lingrel, J B 1991. Expression of Na,K-ATPase isoforms in human heart. Biochemical and biophysical research communications, 179 3, 1434-40

Anderson, K P; Lingrel, J B 1990. Differential regulation of rat T-kininogen by tumor necrosis factor and interleukin-6. Molecular endocrinology (Baltimore, Md.), 4 4, 543-50

Lingrel, J B; Orlowski, J; Shull, M M; Price, E M 1990. Molecular genetics of Na,K-ATPase. Progress in nucleic acid research and molecular biology, 38 , 37-89

Orlowski, J; Lingrel, J B 1990. Thyroid and glucocorticoid hormones regulate the expression of multiple Na,K-ATPase genes in cultured neonatal rat cardiac myocytes. The Journal of biological chemistry, 265 6, 3462-70

Pathak, B G; Pugh, D G; Lingrel, J B 1990. Characterization of the 5'-flanking region of the human and rat Na,K-ATPase alpha 3 gene. Genomics, 8 4, 641-7

Price, E M; Rice, D A; Lingrel, J B 1990. Structure-function studies of Na,K-ATPase. Site-directed mutagenesis of the border residues from the H1-H2 extracellular domain of the alpha subunit. The Journal of biological chemistry, 265 12, 6638-41

Shull, M M; Pugh, D G; Lane, L K; Lingrel, J B 1990. MspI and PvuII polymorphisms in the Na,K-ATPase beta subunit gene ATP1B1. Nucleic acids research, 18 4, 1087

Shull, M M; Pugh, D G; Lingrel, J B 1990. The human Na, K-ATPase alpha 1 gene: characterization of the 5'-flanking region and identification of a restriction fragment length polymorphism. Genomics, 6 3, 451-60

Shull, M M; Pugh, D G; Lingrel, J B 1990. MspI and PvuII polymorphisms in the Na,K-ATPase alpha subunit related gene ATP1AL1. Nucleic acids research, 18 1, 205

Anderson, K P; Croyle, M L; Lingrel, J B 1989. Primary structure of a gene encoding rat T-kininogen. Gene, 81 1, 119-28

Anderson, K P; Lingrel, J B 1989. Glucocorticoid and estrogen regulation of a rat T-kininogen gene. Nucleic acids research, 17 7, 2835-48

Garner, K J; Lingrel, J B 1989. A comparison of the beta A-and beta B-globin gene clusters of sheep. Journal of molecular evolution, 28 3, 175-84

Georgiou, C; Shull, M; Lane, L K; Lingrel, J B; Murray, J C 1989. RFLPs for ATP1BL1 (beta subunit Na+/K+ ATPase pseudogene) on chromosome 4. Nucleic acids research, 17 21, 8894

Krakowsky, J M; Panke, E S; Lee, R F; McNeish, J; Potter, S S; Lingrel, J B 1989. Analysis of possible repressor elements in the 5'-flanking region of the human beta-globin gene. DNA (Mary Ann Liebert, Inc.), 8 10, 715-21

Lane, L K; Shull, M M; Whitmer, K R; Lingrel, J B 1989. Characterization of two genes for the human Na,K-ATPase beta subunit. Genomics, 5 3, 445-53

Lloyd, J A; Lee, R F; Lingrel, J B 1989. Mutations in two regions upstream of the A gamma globin gene canonical promoter affect gene expression. Nucleic acids research, 17 11, 4339-52

Lloyd, J A; Lee, R F; Menon, A G; Lingrel, J B 1989. Sites I and II upstream of the A gamma globin gene bind nuclear factors and affect gene expression. Progress in clinical and biological research, 316A , 139-48

Price, E M; Rice, D A; Lingrel, J B 1989. Site-directed mutagenesis of a conserved, extracellular aspartic acid residue affects the ouabain sensitivity of sheep Na,K-ATPase. The Journal of biological chemistry, 264 36, 21902-6

Shull, M M; Pugh, D G; Lingrel, J B 1989. Characterization of the human Na,K-ATPase alpha 2 gene and identification of intragenic restriction fragment length polymorphisms. The Journal of biological chemistry, 264 29, 17532-43

Garner, K J; Lingrel, J B 1988. Structural organization of the beta-globin locus of B-haplotype sheep. Molecular biology and evolution, 5 2, 134-40

Lingrel, J B; Young, R M; Shull, M M 1988. Multiple forms of the Na,K-ATPase: their genes and tissue specific expression. Progress in clinical and biological research, 268B , 105-12

Orlowski, J; Lingrel, J B 1988. Differential expression of the Na,K-ATPase alpha 1 and alpha 2 subunit genes in a murine myogenic cell line. Induction of the alpha 2 isozyme during myocyte differentiation. The Journal of biological chemistry, 263 33, 17817-21

Orlowski, J; Lingrel, J B 1988. Tissue-specific and developmental regulation of rat Na,K-ATPase catalytic alpha isoform and beta subunit mRNAs. The Journal of biological chemistry, 263 21, 10436-42

Price, E M; Lingrel, J B 1988. Structure-function relationships in the Na,K-ATPase alpha subunit: site-directed mutagenesis of glutamine-111 to arginine and asparagine-122 to aspartic acid generates a ouabain-resistant enzyme. Biochemistry, 27 22, 8400-8

Shull, G E; Young, R M; Greeb, J; Lingrel, J B 1988. Overview: amino acid sequences of the alpha and beta subunits of the Na,K-ATPase. Progress in clinical and biological research, 268A , 3-18

Yang-Feng, T L; Schneider, J W; Lindgren, V; Shull, M M; Benz, E J; Lingrel, J B; Francke, U 1988. Chromosomal localization of human Na+, K+-ATPase alpha- and beta-subunit genes. Genomics, 2 2, 128-38

Liberator, P A; Lingrel, J B 1987. Chromatin fine-structure mapping of the goat beta F gene in fetal erythroid tissue. Molecular and cellular biology, 7 8, 2772-82

Lingrel, J B; Weimer, J; Menon, A 1987. Binding of nuclear factors to an upstream region of the human A gamma globin gene. Progress in clinical and biological research, 251 , 201-10

Shull, G E; Lingrel, J B 1987. Isolation and characterization of a cDNA for the catalytic subunit of the (Na+ + K+)-ATPase. Society of General Physiologists series, 41 , 301-21

Shull, M M; Lingrel, J B 1987. Multiple genes encode the human Na+,K+-ATPase catalytic subunit. Proceedings of the National Academy of Sciences of the United States of America, 84 12, 4039-43

Young, R M; Lingrel, J B 1987. Tissue distribution of mRNAs encoding the alpha isoforms and beta subunit of rat Na+,K+-ATPase. Biochemical and biophysical research communications, 145 1, 52-8

Young, R M; Shull, G E; Lingrel, J B 1987. Multiple mRNAs from rat kidney and brain encode a single Na+,K+-ATPase beta subunit protein. The Journal of biological chemistry, 262 10, 4905-10

King, D; Snider, L D; Lingrel, J B 1986. Polymorphism in an androgen-regulated mouse gene is the result of the insertion of a B1 repetitive element into the transcription unit. Molecular and cellular biology, 6 1, 209-17

King, D; Sun, Y H; Lingrel, J B 1986. Amino acid sequence of the testosterone-regulated mouse kidney RP2 protein deduced from its complementary DNA sequence. Nucleic acids research, 14 13, 5159-70

Menon, A G; Lingrel, J B 1986. Structural and functional analysis of the goat epsilon-globin genes. Gene, 42 2, 141-50

Shull, G E; Greeb, J; Lingrel, J B 1986. Molecular cloning of three distinct forms of the Na+,K+-ATPase alpha-subunit from rat brain. Biochemistry, 25 25, 8125-32

Shull, G E; Lingrel, J B 1986. Molecular cloning of the rat stomach (H+ + K+)-ATPase. The Journal of biological chemistry, 261 36, 16788-91

Wernke, S M; Lingrel, J B 1986. Nucleotide sequence of the goat embryonic alpha globin gene (zeta) and linkage and evolutionary analysis of the complete alpha globin cluster. Journal of molecular biology, 192 3, 457-71

Lingrel, J B; Townes, T M; Shapiro, S G; Wernke, S M; Liberator, P A; Menon, A G 1985. Structural organization of the alpha and beta globin loci of the goat. Progress in clinical and biological research, 191 , 67-79

Snider, L D; King, D; Lingrel, J B 1985. Androgen regulation of MAK mRNAs in mouse kidney. The Journal of biological chemistry, 260 17, 9884-93

Spence, S E; Young, R M; Garner, K J; Lingrel, J B 1985. Localization and characterization of members of a family of repetitive sequences in the goat beta globin locus. Nucleic acids research, 13 6, 2171-86

Townes, T M; Chen, H Y; Lingrel, J B; Palmiter, R D; Brinster, R L 1985. Expression of human beta-globin genes in transgenic mice: effects of a flanking metallothionein-human growth hormone fusion gene. Molecular and cellular biology, 5 8, 1977-83

Townes, T M; Lingrel, J B; Chen, H Y; Brinster, R L; Palmiter, R D 1985. Erythroid-specific expression of human beta-globin genes in transgenic mice. The EMBO journal, 4 7, 1715-23

Liberator, P A; Lingrel, J B 1984. Restriction endonuclease accessibility of the developmentally regulated goat gamma-, beta C-, and beta A-globin genes in chromatin. Differences in 5' regions which show unusually high sequence homology. The Journal of biological chemistry, 259 24, 15497-501

Shapiro, S G; Lingrel, J B 1984. Identification of a recently evolved goat embryonic beta-globin pseudogene which retains transcriptional activity in vitro. Molecular and cellular biology, 4 10, 2120-7

Townes, T M; Fitzgerald, M C; Lingrel, J B 1984. Triplication of a four-gene set during evolution of the goat beta-globin locus produced three genes now expressed differentially during development. Proceedings of the National Academy of Sciences of the United States of America, 81 21, 6589-93

Townes, T M; Shapiro, S G; Wernke, S M; Lingrel, J B 1984. Duplication of a four-gene set during the evolution of the goat beta-globin locus produced genes now expressed differentially in development. The Journal of biological chemistry, 259 3, 1896-900

Kalb, V F; Glasser, S; King, D; Lingrel, J B 1983. A cluster of repetitive elements within a 700 base pair region in the mouse genome. Nucleic acids research, 11 7, 2177-84

Lingrel, J B; Townes, T M; Shapiro, S G; Spence, S E; Liberator, P A; Wernke, S M 1983. Organization, structure, and expression of the goat globin genes. Progress in clinical and biological research, 134 , 131-9

Shapiro, S G; Schon, E A; Townes, T M; Lingrel, J B 1983. Sequence and linkage of the goat epsilon I and epsilon II beta-globin genes. Journal of molecular biology, 169 1, 31-52

Schon, E A; Wernke, S M; Lingrel, J B 1982. Gene conversion of two functional goat alpha-globin genes preserves only minimal flanking sequences. The Journal of biological chemistry, 257 12, 6825-35

Cleary, M L; Schon, E A; Lingrel, J B 1981. Two related pseudogenes are the result of a gene duplication in the goat beta-globin locus. Cell, 26 2 Pt 2, 181-90

Luse, D S; Haynes, J R; VanLeeuwen, D; Schon, E A; Cleary, M L; Shapiro, S G; Lingrel, J B; Roeder, R G 1981. Transcription of the beta-like globin genes and pseudogenes of the goat in a cell-free system. Nucleic acids research, 9 17, 4339-54

Schon, E A; Cleary, M L; Haynes, J R; Lingrel, J B 1981. Structure and evolution of goat gamma-, beta C- and beta A-globin genes: three developmentally regulated genes contain inserted elements. Cell, 27 2 Pt 1, 359-69

Cleary, M L; Haynes, J R; Schon, E A; Lingrel, J B 1980. Identification by nucleotide sequence analysis of a goat pseudoglobin gene. Nucleic acids research, 8 20, 4791-802

Haynes, J R; Rosteck, P; Lingrel, J B 1980. Unusual sequence homology at the 5-ends of the developmentally regulated beta A-, beta C-, and gamma-globin genes of the goat. Proceedings of the National Academy of Sciences of the United States of America, 77 12, 7127-31

Haynes, J R; Rosteck, P; Schon, E A; Gallagher, P M; Burks, D J; Smith, K; Lingrel, J B 1980. The isolation of the beta A-, beta C-, and gamma-globin genes and a presumptive embryonic globin gene from a goat DNA recombinant library. The Journal of biological chemistry, 255 13, 6355-67

Lowenhaupt, K; Lingrel, J B 1979. Synthesis and turnover of globin mRNA in murine erythroleukemia cells induced with hemin. Proceedings of the National Academy of Sciences of the United States of America, 76 10, 5173-7

Robbins, J; Rosteck, P; Haynes, J R; Freyer, G; Cleary, M L; Kalter, H D; Smith, K; Lingrel, J B 1979. The isolation and partial characterization of recombinant DNA containing genomic globin sequences from the goat. The Journal of biological chemistry, 254 13, 6187-95

Haynes, J R; Kalb, V F; Rosteck, P; Lingrel, J B 1978. The absence of a precursor larger than 16 S to globin mRNA. FEBS letters, 91 2, 173-7

Lowenhaupt, K; Lingrel, J B 1978. A change in the stability of globin mRNA during the induction of murine erythroleukemia cells. Cell, 14 2, 337-44

Lowenhaupt, K; Trent, C; Lingrel, J B 1978. Mechanisms for accumulation of globin mRNA during dimethyl sulfoxide induction of murine erythroleukemia cells: synthesis of precursors and mature mRNA. Developmental biology, 63 2, 441-54

Smith, K; Lingrel, J B 1978. Sequence organization of the beta-globin mRNA precursor. Nucleic acids research, 5 9, 3295-301

Smith, K; Rosteck, P; Lingrel, J B 1978. The location of the globin mRNA sequence within its 16S precursor. Nucleic acids research, 5 1, 105-15

Heckle, W L; Fenton, R G; Wood, T G; Merkel, C G; Lingrel, J B 1977. Methylated nucleosides in globin mRNA from mouse nucleated erythroid cells. The Journal of biological chemistry, 252 5, 1764-70

Kwan, S P; Wood, T G; Lingrel, J B 1977. Purification of a putative precursor of globin messenger RNA from mouse nucleated erythroid cells. Proceedings of the National Academy of Sciences of the United States of America, 74 1, 178-82

Wood, T G; Lingrel, J B 1977. Purification of biologically active globin mRNA using cDNA-cellulose affinity chromatography. The Journal of biological chemistry, 252 2, 457-63

Merkel, C G; Wood, T G; Lingrel, J B 1976. Shortening of the poly(A) region of mouse globin messenger RNA. The Journal of biological chemistry, 251 18, 5512-5

Morrison, M R; Lingrel, J B 1976. Molecular weight determinations on the alpha-globin and beta-globin mRNAs. Biochimica et biophysica acta, 447 1, 104-9

Gorski, J; Morrison, M R; Merkel, C G; Lingrel, J B 1975. Poly(A) size class distribution in globin mRNAs as a function of time. Nature, 253 5494, 749-51

Holder, J W; Lingrel, J B 1975. Determination of secondary structure in rabbit globin messenger RNA by thermal denaturation. Biochemistry, 14 19, 4209-15

Merkel, C G; Kwan, S; Lingrel, J B 1975. Size of the polyadenylic acid region of newly synthesized globin messenger ribonucleic acid. The Journal of biological chemistry, 250 10, 3725-8

Morrison, M R; Lingrel, J B 1975. Characterization of globin messenger ribonucleic acids in membrane polysomes of mouse reticulocytes. The Journal of biological chemistry, 250 3, 848-52

Gorski, J; Morrison, M R; Merkel, C G; Lingrel, J B 1974. Size heterogeneity of polyadenylate sequences in mouse globin messenger RNA. Journal of molecular biology, 86 2, 363-71

Gurdon, J B; Woodland, H R; Lingrel, J B 1974. The translation of mammalian globin mRNA injected into fertilized eggs of Xenopus laevis I. Message stability in development. Developmental biology, 39 1, 125-33

Lingrel, J B; Morrison, M; Gorski, J; Merkel, C G 1974. Various size classes of polyadenylic acid in mouse alpha and beta globin mRNAs and their significance. Annals of the New York Academy of Sciences, 241 0, 156-69

Lingrel, J B; Woodland, H R 1974. Initiation does not limit the rate of globin synthesis in message-injected Xenopus oocytes. European journal of biochemistry / FEBS, 47 1, 47-56

Morrison, M R; Brinkley, S A; Gorski, J; Lingrel, J B 1974. The separation and identification of alpha- and beta-globin messenger ribonucleic acids. The Journal of biological chemistry, 249 16, 5290-5

Woodland, H R; Gurdon, J B; Lingrel, J B 1974. The translation of mammalian globin mRNA injected into fertilized eggs of Xenopus laevis. II. The distribution of globin synthesis in different tissues. Developmental biology, 39 1, 134-40

Gurdon, J B; Lingrel, J B; Marbaix, G 1973. Message stability in injected frog oocytes: long life of mammalian alpha and beta globin messages. Journal of molecular biology, 80 3, 539-51

Lockard, R E; Lingrel, J B 1973. Translation of mammalian globin messenger RNAs in an avian reticulocyte cell-free system. Biochimica et biophysica acta, 299 1, 148-52

Morrison, M R; Merkel, C G; Lingrel, J B 1973. Size of the poly(A) region in mouse globin messenger RNA. Molecular biology reports, 1 1, 55-60

Jones, R F; Lingrel, J B 1972. Peptide analysis of the mouse hemoglobin messenger ribonucleic acid-directed products synthesized in mammalian and avian cell-free systems. The Journal of biological chemistry, 247 24, 7951-5

Lockard, R E; Lingrel, J B 1972. Mouse hemoglobin messenger ribonucleic acid. Translational capacities of rabbit and duck reticulocyte cell-free systems programmed with mouse 9 S ribonucleic acid. The Journal of biological chemistry, 247 13, 4174-9

Morrison, M R; Gorski, J; Lingrel, J B 1972. The separation of mouse reticulocyte 9S RNA into fractions of different biological activity by hybridization to poly(U)-cellulose. Biochemical and biophysical research communications, 49 3, 775-81

Noll, M; Noll, H; Lingrel, J B 1972. Initiation factor IF-3-dependent binding of Escherichia coli ribosomes and N-formylmethionine transfer-RNA to rabbit globin messenger. Proceedings of the National Academy of Sciences of the United States of America, 69 7, 1843-7

Burr, H; Lingrel, J B 1971. Poly A sequences at the 3' termini of rabbit globin mRNAs. Nature: New biology, 233 36, 41-3

Lingrel, J B; Lockard, R E; Jones, R F; Burr, H E; Holder, J W 1971. Biologically active messenger-RNA for hemoglobin. Series haematologica, 4 3, 37-69

Lockard, R E; Lingrel, J B 1971. Identification of mouse haemoglobin messenger RNA. Nature: New biology, 233 41, 204-6

Lockard, R E; Lingrel, J B 1971. Identification of mouse haemoglobin messenger RNA. Nature, 233 5320, 204-6

Mathews, M B; Osborn, M; Lingrel, J B 1971. Translation of globin messenger RNA in a heterologous cell-free system. Nature, 233 5320, 206-9

Mathews, M B; Osbron, M; Lingrel, J B 1971. Translation of globin messenger RNA in a heterologous cell-free system. Nature: New biology, 233 41, 206-9

Holder, J W; Lingrel, J B 1970. The localization of the hemoglobin messenger RNA on the 40-S ribosomal subunit of rabbit reticulocyte polysomes. Biochimica et biophysica acta, 204 1, 210-20

Evans, M J; Lingrel, J B 1969. Hemoglobin messenger ribonucleic acid. Synthesis of 9S and ribosomal ribonucleic acid during erythroid cell development. Biochemistry, 8 7, 3000-5

Evans, M J; Lingrel, J B 1969. Hemoglobin messenger ribonucleic acid. Distribution of the 9S ribonucleic acid in polysomes of different sizes. Biochemistry, 8 3, 829-31

Lockard, R E; Lingrel, J B 1969. The synthesis of mouse hemoglobin beta-chains in a rabbit reticulocyte cell-free system programmed with mouse reticulocyte 9S RNA. Biochemical and biophysical research communications, 37 2, 204-12

Lingrel, J B 1967. Studies on the rapidly labeled RNA of rabbit bone marrow cells. Biochimica et biophysica acta, 142 1, 75-88

Drach, J C; Lingrel, J B 1966. Function of reticulocyte ribonucleic acid in the Escherichia coli cell-free system. Biochimica et biophysica acta, 129 1, 178-85

Drach, J C; Lingrel, J B 1966. The isolation of aribonucleic acid fraction from rabbit reticulocytes which enhances amino acid incorporation into protein. Biochimica et biophysica acta, 123 2, 345-55

DRACH, J C; LINGREL, J B 1964. MESSENGER RIBONUCLEIC ACID ACTIVITY IN RABBIT RETICULOCYTE RIBOSOMES. Biochimica et biophysica acta, 91 , 680-3

BORSOOK, H; LINGREL, J B; SCARO, J L; MILLETTE, R L 1962. Synthesis of haemoglobin in relation to the maturation of erythroid cells. Nature, 196 , 347-50

LINGREL, J B; BORSOOK, H 1962. Haemoglobin minors as possible intermediates in haemoglobin synthesis. Nature, 195 , 355-6

LINGREL, J B; HEINTZ, R L; WEBSTER, G 1962. A labile factor required for the ribosomal incorporation of amino acids into non-particulate proteins. Biochimica et biophysica acta, 59 , 757-8

LINGREL, J B; WEBSTER, G 1961. Serum albumin synthesis by isolated rat liver microsomes. Biochemical and biophysical research communications, 5 , 57-62

Lingrel, J B; Van Huysse, J; O'Brien, W; Jewell-Motz, E; Schultheis, P . Na,K-ATPase: structure-function studies. Renal physiology and biochemistry, 17 3-4, 198-200

Shull, G E; Lane, L K; Lingrel, J B . Amino-acid sequence of the beta-subunit of the (Na+ + K+)ATPase deduced from a cDNA. Nature, 321 6068, 429-31

Shull, G E; Schwartz, A; Lingrel, J B . Amino-acid sequence of the catalytic subunit of the (Na+ + K+)ATPase deduced from a complementary DNA. Nature, 316 6030, 691-5

Simi, L B; Sasi, R; Lingrel, J B; Lin, C C . Mapping of the goat beta-globin gene cluster to a region of chromosome 7 by in situ hybridization. The Journal of heredity, 80 3, 246-9