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Department of

Molecular Genetics, Biochemistry & Microbiology

Photo of  Michael Lieberman, PhD

Michael Lieberman, PhD

Professor and Chair of Molecular Genetics, Biochemistry & Microbiology

Education/Credentials
  • SB: Massachusetts Institute of Technology
  • PhD: Brandeis University

Research/Clinical Interests

My research interests are as follows:analysis of megakaryocyte differentiation is being investigated using cultured mammalian cells as a model system;introduction of dominant negative mutations of proteins known to be important in signal transduction is being carried out, as are alternative means of inducing differentiation in these cells.

Contact Information
  • Office 2253 Medical Sciences Building
  • 231 Albert Sabin Way
  • Cincinnati, Ohio 45267
  • Office (513)558-5645
  • Email michael.lieberman@uc.edu

Peer Reviewed Publications

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Platt, Mark D; Schurr, Michael J; Sauer, Karin; Vazquez, Gustavo; Kukavica-Ibrulj, Irena; Potvin, Eric; Levesque, Roger C; Fedynak, Amber; Brinkman, Fiona S L; Schurr, Jill; Hwang, Sung-Hei; Lau, Gee W; Limbach, Patrick A; Rowe, John J; Lieberman, Michael A; Barraud, Nicolas; Webb, Jeremy; Kjelleberg, Staffan; Hunt, Donald F; Hassett, Daniel J 2008. Proteomic, microarray, and signature-tagged mutagenesis analyses of anaerobic Pseudomonas aeruginosa at pH 6.5, likely representing chronic, late-stage cystic fibrosis airway conditions. Journal of bacteriology, 190 8, 2739-58

Groden, J; Lieberman, M A 2001. Overview of genetics for the clinician. Epilepsia, 42 Suppl 5 , 2-10

Jawa, R S; Quaid, G A; Williams, M A; Cave, C M; Robinson, C T; Babcock, G F; Lieberman, M A; Witt, D; Solomkin, J S 1999. Tumor necrosis factor alpha regulates CXC chemokine receptor expression and function. Shock (Augusta, Ga.), 11 6, 385-90

Denko, N; Langland, R; Barton, M; Lieberman, M A 1997. Uncoupling of S-phase and mitosis by recombinant cytotoxic necrotizing factor 2 (CNF2). Experimental cell research, 234 1, 132-8

Tiao, G; Lieberman, M; Fischer, J E; Hasselgren, P O 1997. Intracellular regulation of protein degradation during sepsis is different in fast- and slow-twitch muscle. The American journal of physiology, 272 3 Pt 2, R849-56

Borges, L G; Seifert, R A; Grant, F J; Hart, C E; Disteche, C M; Edelhoff, S; Solca, F F; Lieberman, M A; Lindner, V; Fischer, E H; Lok, S; Bowen-Pope, D F 1996. Cloning and characterization of rat density-enhanced phosphatase-1, a protein tyrosine phosphatase expressed by vascular cells. Circulation research, 79 3, 570-80

Herman, Jerome H.; O'Connor, Michael P.; Lieberman, Michael A. 1996. Perturbation of a Cartilage Autocrine/Paracrine Basic Fibroblast Growth Factor Metabolic Regulatory Network by Osteoarthritic Synovial Tissue. American journal of therapeutics, 3 1, 52-62

Hudson, K M; Denko, N C; Schwab, E; Oswald, E; Weiss, A; Lieberman, M A 1996. Megakaryocytic cell line-specific hyperploidy by cytotoxic necrotizing factor bacterial toxins. Blood, 88 9, 3465-73

Sandrock, B; Hudson, K M; Williams, D E; Lieberman, M A 1996. Cytokine production by a megakaryocytic cell line. In vitro cellular & developmental biology. Animal, 32 4, 225-33

Tiao, ; Hudson, ; Lieberman, ; Fischer, ; Hasselgren, 1996. Identification of Altered Gene Expression in Skeletal Muscle during Sepsis Using Differential Display The Journal of surgical research, 64 1, 63-7

Tiao, G M; Hudson, K; Lieberman, M A; Fischer, J E; Hasselgren, P O 1996. Identification of altered gene expression in skeletal muscle during sepsis using differential display. The Journal of surgical research, 64 1, 63-7

Tiao, G; Fagan, J; Roegner, V; Lieberman, M; Wang, J J; Fischer, J E; Hasselgren, P O 1996. Energy-ubiquitin-dependent muscle proteolysis during sepsis in rats is regulated by glucocorticoids. The Journal of clinical investigation, 97 2, 339-48

Tiao, G; Noguchi, Y; Lieberman, M A; Fischer, J E; Hasselgren, P O 1995. Sepsis stimulates polyamine biosynthesis in the liver and increases tissue levels of ornithine decarboxylase mRNA. Shock (Augusta, Ga.), 4 6, 403-10

Kiffmeyer, W R; Stambrook, P J; Lieberman, M A 1994. Retroviral mediated gene transfer in megakaryocytic cell lines. In vitro cellular & developmental biology. Animal, 30A 11, 803-9

Namciu, S; Lieberman, M A; Stavnezer, E 1994. Induction of the c-ski proto-oncogene by phorbol ester correlates with induction of megakaryocyte differentiation. Oncogene, 9 5, 1407-16

Tiao, G; Fagan, J M; Samuels, N; James, J H; Hudson, K; Lieberman, M; Fischer, J E; Hasselgren, P O 1994. Sepsis stimulates nonlysosomal, energy-dependent proteolysis and increases ubiquitin mRNA levels in rat skeletal muscle. The Journal of clinical investigation, 94 6, 2255-64

Armstrong, E; Korhonen, J; Silvennoinen, O; Cleveland, J L; Lieberman, M A; Alitalo, R 1993. Expression of tie receptor tyrosine kinase in leukemia cell lines. Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 7 10, 1585-91

Jones, C L; Witte, D P; Feller, M J; Fugman, D A; Dorn, G W; Lieberman, M A 1992. Response of a human megakaryocytic cell line to thrombin: increase in intracellular free calcium and mitogen release. Biochimica et biophysica acta, 1136 3, 272-82

Liu, H S; Scrable, H; Villaret, D B; Lieberman, M A; Stambrook, P J 1992. Control of Ha-ras-mediated mammalian cell transformation by Escherichia coli regulatory elements. Cancer research, 52 4, 983-9

Nagasaki, T; Lieberman, M A 1991. Potentiation of the activity of mouse liver-derived HBGF-1-like growth factor by heparin and dithiothreitol: evidence for the involvement of a plasma factor. Biochimica et biophysica acta, 1094 3, 330-8

Nagasaki, T; Lieberman, M A 1991. Liver contains heparin-binding growth factors as the major growth factor for cultured fibroblasts. Hepatology (Baltimore, Md.), 13 1, 6-14

Fugman, D A; Witte, D P; Jones, C L; Aronow, B J; Lieberman, M A 1990. In vitro establishment and characterization of a human megakaryoblastic cell line. Blood, 75 6, 1252-61

Ratner, N; Lieberman, M A; Riccardi, V M; Hong, D M 1990. Mitogen accumulation in von Recklinghausen neurofibromatosis. Annals of neurology, 27 3, 298-303

Witte, D P; Nagasaki, T; Stambrook, P; Lieberman, M A 1989. Identification of an acidic fibroblast growth factor-like activity in a mesoblastic nephroma. Laboratory investigation; a journal of technical methods and pathology, 60 3, 353-9

Ratner, N; Hong, D M; Lieberman, M A; Bunge, R P; Glaser, L 1988. The neuronal cell-surface molecule mitogenic for Schwann cells is a heparin-binding protein. Proceedings of the National Academy of Sciences of the United States of America, 85 18, 6992-6

Witte, D P; Stambrook, P J; Feliciano, E; Jones, C L; Lieberman, M A 1988. Growth factor production by a human megakaryocytic tumor cell line. Journal of cellular physiology, 137 1, 86-94

Nagasaki, T; Lieberman, M A 1987. Heparin potentiates the action of plasma membrane-associated growth stimulatory activity. Journal of cellular physiology, 133 2, 365-71

Nagasaki, T; Lieberman, M A 1987. Growth-stimulatory action of plasma membrane-associated growth factor. A synergistic effect with platelet-poor plasma. Experimental cell research, 170 1, 170-4

Whitsett, J A; Weaver, T E; Lieberman, M A; Clark, J C; Daugherty, C 1987. Differential effects of epidermal growth factor and transforming growth factor-beta on synthesis of Mr = 35,000 surfactant-associated protein in fetal lung. The Journal of biological chemistry, 262 16, 7908-13

Grupp, S A; Lieberman, M A; Harmony, J A 1985. Inhibition of lymphocyte proliferation by detergent-solubilized mouse liver membranes. The Journal of cell biology, 101 2, 380-5

Lieberman, M A 1984. The presence of both growth inhibitory and growth stimulatory factors on membranes prepared from mouse liver. Biochemical and biophysical research communications, 120 3, 891-7

Lieberman, M A 1983. Mitogenic proteins of the 3T3 plasma membrane. Journal of cellular physiology, 114 1, 73-6

Lieberman, M A; Keller-McGandy, C E; Woolsey, T A; Glaser, L 1982. Binding of isolated 3T3 surface membranes to growing 3T3 cells and their effect on cell growth. Journal of cellular biochemistry, 20 1, 81-93

Lieberman, M A; Deuel, T F; Glaser, L 1981. Increased epidermal growth factor binding to Go-arrested 3T3 cells. FEBS letters, 126 1, 45-8

Lieberman, M A; Glaser, L 1981. Density-dependent regulation of cell growth: an example of a cell-cell recognition phenomenon. The Journal of membrane biology, 63 1-2, 1-11

Lieberman, M A; Raben, D; Glaser, L 1981. Cell surface-associated growth inhibitory proteins. Experimental cell research, 133 2, 413-9

Raben, D; Lieberman, M A; Glaser, L 1981. Growth inhibitory protein(s) in the 3T3 cell plasma membrane. Partial purification and dissociation of growth inhibitory events from inhibition of amino acid transport. Journal of cellular physiology, 108 1, 35-45

Lieberman, M A; Rothenberg, P; Raben, D M; Glaser, L 1980. Effect of 3T3 plasma membranes on cells exposed to epidermal growth factor. Biochemical and biophysical research communications, 92 2, 696-702

Bunge, R; Glaser, L; Lieberman, M; Raben, D; Salzer, J; Whittenberger, B; Woolsey, T 1979. Growth control by cell to cell contact. Journal of supramolecular structure, 11 2, 175-87

Hong, J S; Hunt, A G; Masters, P S; Lieberman, M A 1979. Requirements of acetyl phosphate for the binding protein-dependent transport systems in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America, 76 3, 1213-7

Lieberman, M A; Raben, D M; Whittenberger, B; Glaser, L 1979. Effect of plasma membranes on solute transport in 3T3 cells. The Journal of biological chemistry, 254 14, 6357-61

Whittenberger, B; Raben, D; Lieberman, M A; Glaser, L 1978. Inhibition of growth of 3T3 cells by extract of surface membranes. Proceedings of the National Academy of Sciences of the United States of America, 75 11, 5457-61

Hong, J S; Haggerty, D L; Lieberman, M A 1977. Energy coupling factor as target of colicin K: characterization of a colicin K-insensitive ecf mutant of Escherichia coli. Antimicrobial agents and chemotherapy, 11 5, 881-7

Lieberman, M A; Simon, M; Hong, J S 1977. Characterization of Escherichia coli mutant incapable of maintaining a transmembrane potential. MetC ecfts mutations. The Journal of biological chemistry, 252 12, 4056-67

Lieberman, M A; Hong, J S 1976. Changes in active transport, intracellular adenosine 5'-triphosphate levels, macromolecular syntheses, and glycolysis in an energy-uncoupled mutant of Escherichia coli. Journal of bacteriology, 125 3, 1024-31

Lieberman, M A; Hong, J S 1976. Energization of osmotic shock-sensitive transport systems in Escherichia coli requires more than ATP. Archives of biochemistry and biophysics, 172 1, 312-5

Lieberman, M A; Hong, J S 1974. A mutant of Escherichia coli defective in the coupling of metabolic energy to active transport. Proceedings of the National Academy of Sciences of the United States of America, 71 11, 4395-9

Brehm, B J; Summer, S S; Khoury, J C; Filak, A T; Lieberman, M A; Heubi, J E . Health Status and Lifestyle Habits of US Medical Students: A Longitudinal Study. Annals of medical and health sciences research, 6 6, 341-347