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Department of

Molecular Genetics, Biochemistry & Microbiology

Photo of  Edmund Choi, PhD

Edmund Choi, PhD

Associate Professor of Molecular Genetics

Education/Credentials
  • B.A.: University of California, Berkeley
  • Ph.D.: University of California, Los Angeles
  • Post Doc: Harvard School of Medicine

Research/Clinical Interests

Immunology and Microbial Pathogenesis. Antigen Presentation and variability in TRBV haplotype frequency.

Contact Information
  • Office 2251 Medical Sciences Building
  • 231 Albert Sabin Way
  • Cincinnati, Ohio 45267
  • Office 513-558-0067
  • Email edmund.choi@uc.edu

Peer Reviewed Publications

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Brzezinski, J L; Deka, R; Menon, A G; Glass, D N; Choi, E 2005. Variability in TRBV haplotype frequency and composition in Caucasian, African American, Western African and Chinese populations. International journal of immunogenetics, 32 6, 413-20

Brzezinski, J L; Glass, D N; Choi, E 2001. A novel polymorphism in the pseudogene TCRBV5S5 combines with TCRBV6S1 to define three haplotypes. Genes and immunity, 2 5, 290-1

Cullen, C M; Jameson, S C; DeLay, M; Cottrell, C; Becken, E T; Choi, E; Hirsch, R 1999. A divalent major histocompatibility complex/IgG1 fusion protein induces antigen-specific T cell activation in vitro and in vivo. Cellular immunology, 192 1, 54-62

Thompson, S D; Murray, K J; Grom, A A; Passo, M H; Choi, E; Glass, D N 1998. Comparative sequence analysis of the human T cell receptor beta chain in juvenile rheumatoid arthritis and juvenile spondylarthropathies: evidence for antigenic selection of T cells in the synovium. Arthritis and rheumatism, 41 3, 482-97

Grom, A A; von Knorre, C; Murray, K J; Donnelly, P A; Glass, D N; Choi, E 1996. T-cell receptor BV6S1 null alleles and HLA-DR1 haplotypes in polyarticular outcome juvenile rheumatoid arthritis. Human immunology, 45 2, 152-6

Cullen, C M; Blanco, L R; Bonventre, P F; Choi, E 1995. A toxic shock syndrome toxin 1 mutant that defines a functional site critical for T-cell activation. Infection and immunity, 63 6, 2141-6

De Inocencio, J; Choi, E; Glass, D N; Hirsch, R 1995. T cell receptor repertoire differences between African Americans and Caucasians associated with polymorphism of the TCRBV3S1 (V beta 3.1) gene. Journal of immunology (Baltimore, Md. : 1950), 154 9, 4836-41

Lambert, L E; Berling, J S; Thompson, S D; Harton, J A; Bishop, G A; Choi, E 1995. Polymorphism in the beta chain of IAq versus IAp influences presentation of protein but not peptide antigens. Cellular immunology, 165 2, 202-10

Thompson, S D; Grom, A A; Bailey, S; Luyrink, L; Giannini, E H; Murray, K; Passo, M H; Lovell, D J; Choi, E; Glass, D N 1995. Patterns of T lymphocyte clonal expansion in HLA-typed patients with juvenile rheumatoid arthritis. The Journal of rheumatology, 22 7, 1356-64

Grom, A A; Thompson, S D; Luyrink, L; Passo, M; Choi, E; Glass, D N 1993. Dominant T-cell-receptor beta chain variable region V beta 14+ clones in juvenile rheumatoid arthritis. Proceedings of the National Academy of Sciences of the United States of America, 90 23, 11104-8

Luyrink, L; Gabriel, C A; Thompson, S D; Grom, A A; Maksymowych, W P; Choi, E; Glass, D N 1993. Reduced expression of a human V beta 6.1 T-cell receptor allele. Proceedings of the National Academy of Sciences of the United States of America, 90 10, 4369-73

Maksymowych, W P; Gabriel, C A; Luyrink, L; Melin-Aldana, H; Elma, M; Giannini, E H; Lovell, D J; Van Kerckhove, C; Leiden, J; Choi, E 1992. Polymorphism in a T-cell receptor variable gene is associated with susceptibility to a juvenile rheumatoid arthritis subset. Immunogenetics, 35 4, 257-62

Maksymowych, W P; Gabriel, C A; Luyrink, L; Van Kerckhove, C; Leiden, J; Choi, E; Glass, D N 1991. Polymorphic markers related to a single Tcrb-V6 gene segment. Immunogenetics, 33 4, 281-5

van Kerckhove, C; Luyrink, L; Taylor, J; Melin-Aldana, H; Balakrishnan, K; Maksymowych, W; Elma, M; Lovell, D; Choi, E; Glass, D N 1991. HLA-DQA1*0101 haplotypes and disease outcome in early onset pauciarticular juvenile rheumatoid arthritis. The Journal of rheumatology, 18 6, 874-9

Blanco, L; Choi, E M; Connolly, K; Thompson, M R; Bonventre, P F 1990. Mutants of staphylococcal toxic shock syndrome toxin 1: mitogenicity and recognition by a neutralizing monoclonal antibody. Infection and immunity, 58 9, 3020-8

Neudorf, S M; Jones, M M; McCarthy, B M; Harmony, J A; Choi, E M 1990. The CD4 molecule transmits biochemical information important in the regulation of T lymphocyte activity. Cellular immunology, 125 2, 301-14

Van Kerckhove, C; Luyrink, L; Elma, M S; Maksymowych, W P; Levinson, J E; Larson, M G; Choi, E; Glass, D N 1990. HLA-DP/DR interaction in children with juvenile rheumatoid arthritis. Immunogenetics, 32 5, 364-8

Van Kerckhove, C; Melin-Aldana, H; Elma, M S; Luyrink, L; Donnelly, P; Taylor, J; Maksymowych, W P; Lovell, D J; Choi, E; Glass, D N 1990. A distinct HLA-DRw8 haplotype characterizes patients with juvenile rheumatoid arthritis. Immunogenetics, 32 5, 304-8

Welch, T R; Beischel, L S; Choi, E; Balakrishnan, K; Bishof, N A 1990. Uniparental isodisomy 6 associated with deficiency of the fourth component of complement. The Journal of clinical investigation, 86 2, 675-8

Ghogawala, Z; Choi, E; Daly, K R; Blanco, L R; Griffith, I J; Glimcher, L H 1989. An intronic 10-base-pair deletion in a class II A beta gene affects RNA processing. Molecular and cellular biology, 9 10, 4402-8

Lee, J S; Sartoris, S; Briata, P; Choi, E; Cullen, C; Lepaslier, D; Yunis, I 1989. Sequence polymorphism of HLA-DP beta chains. Immunogenetics, 29 5, 346-9

Welch, T R; Beischel, L S; Choi, E M 1989. Molecular genetics of C4B deficiency in IgA nephropathy. Human immunology, 26 4, 353-63

Griffith, I J; Choi, E M; Glimcher, L H 1987. A single base mutation in an I-A alpha-chain gene alters T-cell recognition. Proceedings of the National Academy of Sciences of the United States of America, 84 4, 1090-3

Cohn, L E; Glimcher, L H; Waldmann, R A; Smith, J A; Ben-Nun, A; Seidman, J G; Choi, E 1986. Identification of functional regions on the I-Ab molecule by site-directed mutagenesis. Proceedings of the National Academy of Sciences of the United States of America, 83 3, 747-51

Ben-Nun, A; Choi, E; McIntyre, K R; Leeman, S A; McKean, D J; Seidman, J G; Glimcher, L H 1985. DNA-mediated transfer of major histocompatibility class II I-Ab and I-Abm12 genes into B lymphoma cells: molecular and functional analysis of introduced antigens. Journal of immunology (Baltimore, Md. : 1950), 135 2, 1456-64

Gasser, D L; Klein, K A; Choi, E; Seidman, J G 1985. A new beta-2 microglobulin allele in mice defined by DNA sequencing. Immunogenetics, 22 4, 413-6

Glimcher, L H; McKean, D J; Choi, E; Seidman, J G 1985. Complex regulation of class II gene expression: analysis with class II mutant cell lines. Journal of immunology (Baltimore, Md. : 1950), 135 5, 3542-50

Murre, C; Choi, E; Weis, J; Seidman, J G; Ozato, K; Liu, L; Burakoff, S J; Reiss, C S 1984. Dissection of serological and cytolytic T lymphocyte epitopes on murine major histocompatibility antigens by a recombinant H-2 gene separating the first two external domains. The Journal of experimental medicine, 160 1, 167-78

Seidman, C E; Duby, A D; Choi, E; Graham, R M; Haber, E; Homcy, C; Smith, J A; Seidman, J G 1984. The structure of rat preproatrial natriuretic factor as defined by a complementary DNA clone. Science (New York, N.Y.), 225 4659, 324-6

Choi, E; McIntyre, K; Germain, R N; Seidman, J G 1983. Murine I-A beta chain polymorphism: nucleotide sequences of three allelic I-A beta genes. Science (New York, N.Y.), 221 4607, 283-6

Rogers, J; Choi, E; Souza, L; Carter, C; Word, C; Kuehl, M; Eisenberg, D; Wall, R 1981. Gene segments encoding transmembrane carboxyl termini of immunoglobulin gamma chains. Cell, 26 1 Pt 1, 19-27

Choi, E; Kuehl, M; Wall, R 1980. RNA splicing generates a variant light chain from an aberrantly rearranged kappa gene. Nature, 286 5775, 776-9

Benedict, W F; Baker, M S; Haroun, L; Choi, E; Ames, B N 1977. Mutagenicity of cancer chemotherapeutic agents in the Salmonella/microsome test. Cancer research, 37 7 Pt 1, 2209-13

McCann, J; Choi, E; Yamasaki, E; Ames, B N 1975. Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals. Proceedings of the National Academy of Sciences of the United States of America, 72 12, 5135-9