Education/CredentialsFellowship: Oregon Health Sciences University (Movement Disorders)Residency: University of Cincinnati (Neurology)Residency: The Christ HospitalMedical Degree: Sawai Man Singh Medical College Resident : Sawai Man Singh Medical College: Sawai Man Singh Medical College and Attached HospitalsBachelor's Degree: Sawai Man Singh Medical College Board Certifications & LicensesAmerican Board of Psychiatry and Neurology (Neurology) (Certification Date: 2002-01-22) - (Recertification Date: 2012-02-27) SpecialtiesNeurology Contact Information One Stetson Square 4225 Office 513-558-4050 Email sahaya@ucmail.uc.edu Clinical Interests Movement DisordersNeurologyParkinson's DiseaseAlzheimer's DiseaseAtaxiaBalance DisordersBell's PalsyCataplexyCatatoniaCerebellar AtaxiaChoreaCorticobasal Degeneration (CBD)DementiaDyskinesiasDystoniaEssential Tremor (ET)Gait DisordersHemifacial SpasmHereditary Spastic ParaplegiaHuntington's DiseaseHyperkalemic Periodic ParalysisHypokalemic Periodic ParalysisLewy Body DementiaLewy Body DiseaseMultiple System Atrophy (MSA)Muscle RigidityMuscle SpasticityMyoclonic SeizuresNormal Pressure HydrocephalusOrthostatic Hypotension (Postural Hypotension)ParaparesisParkinson's Hypophonia (Bowing/Atrophy)Posterior Cortical AtrophyPrion DiseasePsychomotor DisordersSensory AtaxiaSerotonin SyndromeSpasmsSpinocerebellar Ataxia (SCA)Spinocerebellar DegenerationsStiff-Person SyndromeSubacute Combined DegenerationTauopathiesTay-Sachs DiseaseTDP-43 ProteinopathiesTics and Tourette SyndromeTourette SyndromeTremorsTropical Spastic ParaparesisVascular Cognitive ImpairmentVascular DementiaWernicke Encephalopathy Peer Reviewed Publications Beal,M. F., Oakes,D., Shoulson,I., Henchcliffe,C., Galpern,W. R., Haas,R., Juncos,J. L., Nutt,J. G., Voss,T. S., Ravina,B., Shults,C. M., Helles,K., Snively,V., Lew,M. F., Griebner,B., Watts,A., Gao,S., Pourcher,E., Bond,L., Kompoliti,K., Agarwal,P., Sia,C., Jog,M., Cole,L., Sultana,M., Kurlan,R., Richard,I., Deeley,C., Waters,C. H., Figueroa,A., Arkun,A., Brodsky,M., Ondo,W. G., Hunter,C. B., Jimenez-Shahed,J., Palao,A., Miyasaki,J. M., So,J., Tetrud,J., Reys,L., Smith,K., Singer,C., Blenke,A., Russell,D. S., Cotto,C., Friedman,J. H., Lannon,M., Zhang,L., Drasby,E., Kumar,R., Subramanian,T., Ford,D. S., Grimes,D. A., Cote,D., Conway,J., Siderowf,A. D., Evatt,M. L., Sommerfeld,B., Lieberman,A. N., Okun,M. S., Rodriguez,R. L., Merritt,S., Swartz,C. L., Martin,W. R., King,P., Stover,N., Guthrie,S., Watts,R. L., Ahmed,A., Fernandez,H. H., Winters,A., Mari,Z., Dawson,T. M., Dunlop,B., Feigin,A. S., Shannon,B., Nirenberg,M. J., Ogg,M., Ellias,S. A., Thomas,C. A., Frei,K., Bodis-Wollner,I., Glazman,S., Mayer,T., Hauser,R. A., Pahwa,R., Langhammer,A., Ranawaya,R., Derwent,L., Sethi,K. D., Farrow,B., Prakash,R., Litvan,I., Robinson,A., Sahay,A., Gartner,M., Hinson,V. K., Markind,S., Pelikan,M., Perlmutter,J. S., Hartlein,J., Molho,E., Evans,S., Adler,C. H., Duffy,A., Lind,M., Elmer,L., Davis,K., Spears,J., Wilson,S., Leehey,M. A., Hermanowicz,N., Niswonger,S., Shill,H. A., Obradov,S., Rajput,A., Cowper,M., Lessig,S., Song,D., Fontaine,D., Zadikoff,C., Williams,K., Blindauer,K. A., Bergholte,J., Propsom,C. S., Stacy,M. A., Field,J., Mihaila,D., Chilton,M., Uc,E. Y., Sieren,J., Simon,D. K., Kraics,L., Silver,A., Boyd,J. T., Hamill,R. W., Ingvoldstad,C., Young,J., Thomas,K., Kostyk,S. K., Wojcieszek,J., Pfeiffer,R. F., Panisset,M., Beland,M., Reich,S. G., Cines,M., Zappala,N., Rivest,J., Zweig,R., Lumina,L. P., Hilliard,C. L., Grill,S., Kellermann,M., Tuite,P., Rolandelli,S., Kang,U. J., Rao,J., Cook,M. M., Severt,L., Boyar,K., Investigators,Parkinson Study Group QE3 2014. A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit JAMA Neurol, 71 5, 543Hauser,R. A., Silver,D., Choudhry,A., Eyal,E., Isaacson,S., investigators,ANDANTE study 2014. Randomized, controlled trial of rasagiline as an add-on to dopamine agonists in Parkinson';s disease Mov Disord, 29 8, 1028Marek,K., Seibyl,J., Eberly,S., Oakes,D., Shoulson,I., Lang,A. E., Hyson,C., Jennings,D., Investigators,Parkinson Study Group PRECEPT 2014. Longitudinal follow-up of SWEDD subjects in the PRECEPT Study Neurology, 82 20, 1791Nalls,M. A., Pankratz,N., Lill,C. M., Do,C. B., Hernandez,D. G., Saad,M., DeStefano,A. L., Kara,E., Bras,J., Sharma,M., Schulte,C., Keller,M. F., Arepalli,S., Letson,C., Edsall,C., Stefansson,H., Liu,X., Pliner,H., Lee,J. H., Cheng,R., Ikram,M. A., Ioannidis,J. P., Hadjigeorgiou,G. M., Bis,J. C., Martinez,M., Perlmutter,J. S., Goate,A., Marder,K., Fiske,B., Sutherland,M., Xiromerisiou,G., Myers,R. H., Clark,L. N., Stefansson,K., Hardy,J. A., Heutink,P., Chen,H., Wood,N. W., Houlden,H., Payami,H., Brice,A., Scott,W. K., Gasser,T., Bertram,L., Eriksson,N., Foroud,T., Singleton,A. B., (IPDGC),International Parkinson's Disease Genomics Consortium, (PROGENI),Parkinson's Study Group (PSG) Parkinson's Research: The Organized GENetics Initiative, 23andMe, GenePD, (NGRC),NeuroGenetics Research Consortium, (HIHG),Hussman Institute of Human Genomics, Investigator,Ashkenazi Jewish Dataset, (CHARGE),Cohorts for Health and Aging Research in Genetic Epidemiology, (NABEC),North American Brain Expression Consortium, (UKBEC),United Kingdom Brain Expression Consortium, Consortium,Greek Parkinson's Disease, Group,Alzheimer Genetic Analysis 2014. Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson';s disease Nat Genet, 46 9, 989Stocchi,F., investigators,ADAGIO 2014. Benefits of treatment with rasagiline for fatigue symptoms in patients with early Parkinson';s disease Eur J Neurol, 21 2, 357Evidente,V. G., Fernandez,H. H., LeDoux,M. S., Brashear,A., Grafe,S., Hanschmann,A., Comella,C. L. 2013. A randomized, double-blind study of repeated incobotulinumtoxinA (Xeomin(®)) in cervical dystonia J Neural Transm, 120 12, 1699Fernandez,H. H., Pappert,E. J., Comella,C. L., Evidente,V. G., Truong,D. D., Verma,A., Jankovic,J. 2013. Efficacy and Safety of IncobotulinumtoxinA in Subjects Previously Treated with Botulinum Toxin Versus Toxin-Naïve Subjects with Cervical Dystonia Tremor Other Hyperkinet Mov (N Y), 3 , Group,Parkinson Study 2013. Phase II safety, tolerability, and dose selection study of isradipine as a potential disease-modifying intervention in early Parkinson';s disease (STEADY-PD) Mov Disord, 28 13, 1823Truong,D. D., Gollomp,S. M., Jankovic,J., LeWitt,P. A., Marx,M., Hanschmann,A., Fernandez,H. H., Group,Xeomin US Blepharospasm Study 2013. Sustained efficacy and safety of repeated incobotulinumtoxinA (Xeomin(®)) injections in blepharospasm J Neural Transm, 120 9, 1345Pankratz,N., Beecham,G. W., DeStefano,A. L., Dawson,T. M., Doheny,K. F., Factor,S. A., Hamza,T. H., Hung,A. Y., Hyman,B. T., Ivinson,A. J., Krainc,D., Latourelle,J. C., Clark,L. N., Marder,K., Martin,E. R., Mayeux,R., Ross,O. A., Scherzer,C. R., Simon,D. K., Tanner,C., Vance,J. M., Wszolek,Z. K., Zabetian,C. P., Myers,R. H., Payami,H., Scott,W. K., Foroud,T., Consortium,PD GWAS 2012. Meta-analysis of Parkinson';s disease: identification of a novel locus, RIT2 Ann Neurol, 71 3, 370Comella,C. L., Jankovic,J., Truong,D. D., Hanschmann,A., Grafe,S., Group,U. S. XEOMIN Cervical Dystonia Study 2011. Efficacy and safety of incobotulinumtoxinA (NT 201, XEOMIN®, botulinum neurotoxin type A, without accessory proteins) in patients with cervical dystonia J Neurol Sci, 308 1-2, 103Espay,A. J., Dwivedi,A. K., Payne,M., Gaines,L., Vaughan,J. E., Maddux,B. N., Slevin,J. T., Gartner,M., Sahay,A., Revilla,F. J., Duker,A. P., Shukla,R. 2011. Methylphenidate for gait impairment in Parkinson disease A randomized clinical trial Neurology, 76 14, 1256Espay,Alberto J., Giuffrida,Joe P., Chen,Robert, Payne,Megan, Mazzella,Filomena, Dunn,Emily, Vaughan,Jennifer E., Duker,Andrew P., Sahay,Alok, Kim,Sang Jin, Revilla,Fredy J., Heldman,Dustin A. 2011. Differential response of speed, amplitude, and rhythm to dopaminergic medications in Parkinson';s disease Movement Disorders, 26 14, 2504Espay,Alberto J., Vaughan,Jennifer E., Shukla,Rakesh, Gartner,Maureen, Sahay,Alok, Revilla,Fredy J., Duker,Andrew P. 2011. Botulinum Toxin Type A for Levodopa-Induced Cervical Dyskinesias in Parkinson';s Disease: Unfavorable Risk-Benefit Ratio Movement Disorders, 26 5, 913Heldman,Dustin A., Giuffrida,Joseph P., Chen,Robert, Payne,Megan, Mazzella,Filomena, Duker,Andrew P., Sahay,Alok, Kim,Sang Jin, Revilla,Fredy J., Espay,Alberto J. 2011. The Modified Bradykinesia Rating Scale for Parkinson';s Disease: Reliability and Comparison with Kinematic Measures Movement Disorders, 26 10, 1859Kieburtz,Karl, Parkinson Study Grp Prami,B. I. D. 2011. Twice-Daily, Low-Dose Pramipexole in Early Parkinson';s Disease: A Randomized, Placebo-Controlled Trial Movement Disorders, 26 1, 37Marras,Connie, McDermott,Michael P., Marek,Ken, Rochon,Paula, Naglie,Gary, Tanner,Caroline M., Rudolph,Alice, Shoulson,Ira, Lang,Anthony E., Parkinson Study Grp,Datatop Invest, Parkinson Study Grp,Precept Invest 2011. Predictors of Time to Requiring Dopaminergic Treatment in 2 Parkinson';s Disease Cohorts Movement Disorders, 26 4, 608Pankratz,N., Dumitriu,A., Hetrick,K. N., Sun,M., Latourelle,J. C., Wilk,J. B., Halter,C., Doheny,K. F., Gusella,J. F., Nichols,W. C., Myers,R. H., Foroud,T., DeStefano,A. L., PSG-PROGENI and GenePD Investigators,C.ordinators and Molecular Genetic Laboratories 2011. Copy number variation in familial Parkinson disease PLoS One, 6 8, e20988Schwarzschild,Michael A., Marek,Kenneth, Eberly,Shirley, Oakes,David, Shoulson,Ira, Jennings,Danna, Seibyl,John, Ascherio,Alberto, Parkinson Study Grp,Precept 2011. Serum Urate and Probability of Dopaminergic Deficit in Early "Parkinson';s Disease" Movement Disorders, 26 10, 1864Schwid,Steven R., Bausch,Janice, Oakes,David, Schuchter,Lynn, Tanner,Caroline, Forrest,Misser, Lang,Anthony E., Shoulson,Ira, Investigators,Psg Precept 2010. Cancer Incidence in a Trial of an Antiapoptotic Agent for Parkinson';s Disease Movement Disorders, 25 12, 1801Simon,David K., Pankratz,Nathan, Kissell,Diane K., Pauciulo,Michael W., Halter,Cheryl A., Rudolph,Alice, Pfeiffer,Ronald F., Nichols,William C., Foroud,Tatiana, Parkinson Study Grp,Progeni Invest 2010. Maternal inheritance and mitochondrial DNA variants in familial Parkinson';s disease Bmc Medical Genetics, 11 , Watts,R. L., Lyons,K. E., Pahwa,R., Sethi,K., Stern,M., Hauser,R. A., Olanow,W., Gray,A. M., Adams,B., Earl,N. L., Investigators,228 Study 2010. Onset of dyskinesia with adjunct ropinirole prolonged-release or additional levodopa in early Parkinson';s disease Mov Disord, 25 7, 858Latourelle,J. C., Pankratz,N., Dumitriu,A., Wilk,J. B., Goldwurm,S., Pezzoli,G., Mariani,C. B., DeStefano,A. L., Halter,C., Gusella,J. F., Nichols,W. C., Myers,R. H., Foroud,T., PROGENI Investigators,C.ordinators and Molecular Genetic Laboratories, GenePD Investigators,C.ordinators and Molecular Genetic Laboratories 2009. Genomewide association study for onset age in Parkinson disease BMC Med Genet, 10 , 98Marras,Connie, Lang,Anthony E., Eberly,Shirley W., Oakes,David, Fahn,Stanley, Schwid,Steven R., Hyson,Christopher, Shoulson,Ira, Parkinson Study Grp,Datatop Precep 2009. A Comparison of Treatment Thresholds in Two Large Parkinson';s Disease Clinical Trial Cohorts Movement Disorders, 24 16, 2370Nichols,W. C., Kissell,D. K., Pankratz,N., Pauciulo,M. W., Elsaesser,V. E., Clark,K. A., Halter,C. A., Rudolph,A., Wojcieszek,J., Pfeiffer,R. F., Foroud,T., Parkinson Study Grp,Progeni Invest 2009. Variation in GIGYF2 is not associated with Parkinson disease Neurology, 72 22, 1886Nichols,W. C., Pankratz,N., Marek,D. K., Pauciulo,M. W., Elsaesser,V. E., Halter,C. A., Rudolph,A., Wojcieszek,J., Pfeiffer,R. F., Foroud,T., Parkinson Study Grp,Progeni 2009. Mutations in GBA are associated with familial Parkinson disease susceptibility and age at onset Neurology, 72 4, 310Olanow,C. W., Rascol,O., Hauser,R., Feigin,P. D., Jankovic,J., Lang,A., Langston,W., Melamed,E., Poewe,W., Stocchi,F., Tolosa,E., Investigators,ADAGIO Study 2009. A double-blind, delayed-start trial of rasagiline in Parkinson';s disease N Engl J Med, 361 13, 1268Pankratz,N., Kissell,D. K., Pauciulo,M. W., Halter,C. A., Rudolph,A., Pfeiffer,R. F., Marder,K. S., Foroud,T., Nichols,W. C., Parkinson Study Grp,Progeni Invest 2009. Parkin dosage mutations have greater pathogenicity in familial PD than simple sequence mutations Neurology, 73 4, 279Pankratz,N., Wilk,J. B., Latourelle,J. C., DeStefano,A. L., Halter,C., Pugh,E. W., Doheny,K. F., Gusella,J. F., Nichols,W. C., Foroud,T., Myers,R. H., PSG-PROGENI and GenePD Investigators,C.ordinators and Molecular Genetic Laboratories 2009. Genomewide association study for susceptibility genes contributing to familial Parkinson disease Hum Genet, 124 6, 593Pankratz,Nathan, Nichols,William C., Elsaesser,Veronika E., Pauciulo,Michael W., Marek,Diane K., Halter,Cheryl A., Wojcieszek,Joanne, Rudolph,Alice, Pfeiffer,Ronald F., Foroud,Tatiana, Parkinson Study Grp,Progeni Invest 2009. Alpha-Synuclein and Familial Parkinson';s Disease Movement Disorders, 24 8, 1125Pankratz,N., Marder,K. S., Halter,C. A., Rudolph,A., Shults,C. W., Nichols,W. C., Foroud,T., Investigators,Parkinson's Study Group-PROGENI 2008. Clinical correlates of depressive symptoms in familial Parkinson';s disease Mov Disord, 23 15, 2216Schwarzschild,M. A., Schwid,S. R., Marek,K., Watts,A., Lang,A. E., Oakes,D., Shoulson,I., Ascherio,A., Hyson,C., Gorbold,E., Rudolph,A., Kieburtz,K., Fahn,S., Gauger,L., Goetz,C., Seibyl,J., Forrest,M., Ondrasik,J., Investigators,Parkinson Study Group PRECEPT 2008. Serum urate as a predictor of clinical and radiographic progression in Parkinson disease Arch Neurol, 65 6, 716Goetz,C. G., Damier,P., Hicking,C., Laska,E., Müller,T., Olanow,C. W., Rascol,O., Russ,H. 2007. Sarizotan as a treatment for dyskinesias in Parkinson';s disease: a double-blind placebo-controlled trial Mov Disord, 22 2, 179Investigators,Parkinson Study Group PRECEPT 2007. Mixed lineage kinase inhibitor CEP-1347 fails to delay disability in early Parkinson disease Neurology, 69 15, 1480Nichols,W. C., Elsaesser,V. E., Pankratz,N., Pauciulo,M. W., Marek,D. K., Halter,C. A., Rudolph,A., Shults,C. W., Foroud,T., Parkinson Study Grp,Progeni Invest 2007. LRRK2 mutation analysis in Parkinson disease families with evidence of linkage to PARK8 Neurology, 69 18, 1737Nichols,William C., Marek,Diane K., Pauciulo,Michael W., Pankratz,Nathan, Halter,Cheryl A., Rudolph,Alice, Shults,Clifford W., Wojcieszek,Joanne, Foroud,Tatiana, Investigators,Progeni 2007. R1514Q substitution in Lrrk2 is not a pathogenic Parkinson';s disease mutation Movement Disorders, 22 2, 254Blindauer,K., Shoulson,I., Oakes,D., Kieburtz,K., Schwid,S., Fahn,S., Stern,M., Goetz,C., Nutt,J., Plumb,S., Shinaman,A., Truong,D., Pahwa,R., Factor,S., Evans,S., Wojcieszek,J., Belden,J., Adler,C., Lind,M., Panisset,M., Hall,J., Suchowersky,O., Derwent,L., Di Rocco,A., Boyar,K., Ondo,W., Hunter,C., Colcher,A., Aminoff,M., Dowling,G., Outlaw,H., Dalvi,A., Sahay,A., Schwieterman,D., Elmer,L., Weiner,W., Cines,M., Dignon,C., Frucht,S., Benabou,R., Rajput,A., Ewanishin,M., Jennings,D., Stavris,K., Martin,W., McInnes,G., King,P., Feigin,A., Shannon,B., Gordon,M. F., Atchison,P., Mendis,T., Mendis,N., Reich,S., Dunlop,B., Petzinger,G., Armstrong,C., Welsh,M., Pfeiffer,R., Pfeiffer,B., Tuite,P., Calabrese,V., Roberge,P., Jog,M., Horn,C., Blackstone,C., Growdon,J., Tennis,M., Hauser,R., Gauger,L., Stacy,M., Williamson,K., O'Brien,C., Seeberger,L., Judd,D., Demarcaida,A., Belber,S., Perlmutter,J., McGee-Minnich,L., Ramos,C. S., Berrios,L., Bertoni,J., Peterson,C., Marshall,F., Deeley,C., Verhagen,L., Jaglin,J., Koller,W., Lyons,K., Singer,C., Blenke,A., Mark,M., Caputo,D., Tarsy,D., Scollins,L., Thomas,C. A., Rivest,J., Soucy,D., Bausch,J., Brocht,A., Daigneault,S., Eberly,S., Irvine,C., Lindsay,P., Weaver,C., Tariot,P., Cox,C., Leventhal,C., Goren,S., Sayag,N., Scolnik,M., Levy,R., Eyal,E., Salzman,P., Pagano,M., Parkinson Study,Grp 2006. A randomized controlled trial of etilevodopa in patients with Parkinson disease who have motor fluctuations Archives of Neurology, 63 2, 210Pankratz,N., Pauciulo,M. W., Elsaesser,V. E., Marek,D. K., Halter,C. A., Rudolph,A., Shults,C. W., Foroud,T., Nichols,W. C., Investigators,Parkinson Study Group-PROGENI 2006. Mutations in LRRK2 other than G2019S are rare in a north American-based sample of familial Parkinson';s disease Mov Disord, 21 12, 2257Pankratz,Nathan, Pauciulo,Michael W., Elsaesser,Veronika E., Marek,Diane K., Halter,Cheryl A., Wojcieszek,Joanne, Rudolph,Alice, Shults,Clifford W., Foroud,Tatiana, Nichols,William C., Parkinson Study Grp,Progeni Invest 2006. Mutations in DJ-1 are rare in familial Parkinson disease Neuroscience letters, 408 3, 209Schmit,J. M., Riley,M. A., Dalvi,A., Sahay,A., Shear,P. K., Shockley,K. D., Pun,R. Y. 2006. Deterministic center of pressure patterns characterize postural instability in Parkinson';s disease Exp Brain Res, 168 3, 357Strong,J. A., Dalvi,A., Revilla,F. J., Sahay,A., Samaha,F. J., Welge,J. A., Gong,J., Gartner,M., Yue,X., Yu,L. 2006. Genotype and smoking history affect risk of levodopa-induced dyskinesias in Parkinson';s disease Mov Disord, 21 5, 654Yang,T., Lu,A. G., Ran,R. Q., Aronow,B. J., Schorry,E. K., Hopkin,R. J., Gilbert,D. L., Glauser,T. A., Hershey,A. D., Richtand,N. W., Privitera,M., Dalvi,A., Sahay,A., Szaflarski,J. P., Ficker,D. M., Ratner,N., Sharp,F. R. 2004. Human blood genomics: distinct profiles for gender, age and neurofibromatosis type 1 Molecular Brain Research, 132 2, 155
Clinical Interests Movement DisordersNeurologyParkinson's DiseaseAlzheimer's DiseaseAtaxiaBalance DisordersBell's PalsyCataplexyCatatoniaCerebellar AtaxiaChoreaCorticobasal Degeneration (CBD)DementiaDyskinesiasDystoniaEssential Tremor (ET)Gait DisordersHemifacial SpasmHereditary Spastic ParaplegiaHuntington's DiseaseHyperkalemic Periodic ParalysisHypokalemic Periodic ParalysisLewy Body DementiaLewy Body DiseaseMultiple System Atrophy (MSA)Muscle RigidityMuscle SpasticityMyoclonic SeizuresNormal Pressure HydrocephalusOrthostatic Hypotension (Postural Hypotension)ParaparesisParkinson's Hypophonia (Bowing/Atrophy)Posterior Cortical AtrophyPrion DiseasePsychomotor DisordersSensory AtaxiaSerotonin SyndromeSpasmsSpinocerebellar Ataxia (SCA)Spinocerebellar DegenerationsStiff-Person SyndromeSubacute Combined DegenerationTauopathiesTay-Sachs DiseaseTDP-43 ProteinopathiesTics and Tourette SyndromeTourette SyndromeTremorsTropical Spastic ParaparesisVascular Cognitive ImpairmentVascular DementiaWernicke Encephalopathy
Peer Reviewed Publications Beal,M. F., Oakes,D., Shoulson,I., Henchcliffe,C., Galpern,W. R., Haas,R., Juncos,J. L., Nutt,J. G., Voss,T. S., Ravina,B., Shults,C. M., Helles,K., Snively,V., Lew,M. F., Griebner,B., Watts,A., Gao,S., Pourcher,E., Bond,L., Kompoliti,K., Agarwal,P., Sia,C., Jog,M., Cole,L., Sultana,M., Kurlan,R., Richard,I., Deeley,C., Waters,C. H., Figueroa,A., Arkun,A., Brodsky,M., Ondo,W. G., Hunter,C. B., Jimenez-Shahed,J., Palao,A., Miyasaki,J. M., So,J., Tetrud,J., Reys,L., Smith,K., Singer,C., Blenke,A., Russell,D. S., Cotto,C., Friedman,J. H., Lannon,M., Zhang,L., Drasby,E., Kumar,R., Subramanian,T., Ford,D. S., Grimes,D. A., Cote,D., Conway,J., Siderowf,A. D., Evatt,M. L., Sommerfeld,B., Lieberman,A. N., Okun,M. S., Rodriguez,R. L., Merritt,S., Swartz,C. L., Martin,W. R., King,P., Stover,N., Guthrie,S., Watts,R. L., Ahmed,A., Fernandez,H. H., Winters,A., Mari,Z., Dawson,T. M., Dunlop,B., Feigin,A. S., Shannon,B., Nirenberg,M. J., Ogg,M., Ellias,S. A., Thomas,C. A., Frei,K., Bodis-Wollner,I., Glazman,S., Mayer,T., Hauser,R. A., Pahwa,R., Langhammer,A., Ranawaya,R., Derwent,L., Sethi,K. D., Farrow,B., Prakash,R., Litvan,I., Robinson,A., Sahay,A., Gartner,M., Hinson,V. K., Markind,S., Pelikan,M., Perlmutter,J. S., Hartlein,J., Molho,E., Evans,S., Adler,C. H., Duffy,A., Lind,M., Elmer,L., Davis,K., Spears,J., Wilson,S., Leehey,M. A., Hermanowicz,N., Niswonger,S., Shill,H. A., Obradov,S., Rajput,A., Cowper,M., Lessig,S., Song,D., Fontaine,D., Zadikoff,C., Williams,K., Blindauer,K. A., Bergholte,J., Propsom,C. S., Stacy,M. A., Field,J., Mihaila,D., Chilton,M., Uc,E. Y., Sieren,J., Simon,D. K., Kraics,L., Silver,A., Boyd,J. T., Hamill,R. W., Ingvoldstad,C., Young,J., Thomas,K., Kostyk,S. K., Wojcieszek,J., Pfeiffer,R. F., Panisset,M., Beland,M., Reich,S. G., Cines,M., Zappala,N., Rivest,J., Zweig,R., Lumina,L. P., Hilliard,C. L., Grill,S., Kellermann,M., Tuite,P., Rolandelli,S., Kang,U. J., Rao,J., Cook,M. M., Severt,L., Boyar,K., Investigators,Parkinson Study Group QE3 2014. A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit JAMA Neurol, 71 5, 543Hauser,R. A., Silver,D., Choudhry,A., Eyal,E., Isaacson,S., investigators,ANDANTE study 2014. Randomized, controlled trial of rasagiline as an add-on to dopamine agonists in Parkinson';s disease Mov Disord, 29 8, 1028Marek,K., Seibyl,J., Eberly,S., Oakes,D., Shoulson,I., Lang,A. E., Hyson,C., Jennings,D., Investigators,Parkinson Study Group PRECEPT 2014. Longitudinal follow-up of SWEDD subjects in the PRECEPT Study Neurology, 82 20, 1791Nalls,M. A., Pankratz,N., Lill,C. M., Do,C. B., Hernandez,D. G., Saad,M., DeStefano,A. L., Kara,E., Bras,J., Sharma,M., Schulte,C., Keller,M. F., Arepalli,S., Letson,C., Edsall,C., Stefansson,H., Liu,X., Pliner,H., Lee,J. H., Cheng,R., Ikram,M. A., Ioannidis,J. P., Hadjigeorgiou,G. M., Bis,J. C., Martinez,M., Perlmutter,J. S., Goate,A., Marder,K., Fiske,B., Sutherland,M., Xiromerisiou,G., Myers,R. H., Clark,L. N., Stefansson,K., Hardy,J. A., Heutink,P., Chen,H., Wood,N. W., Houlden,H., Payami,H., Brice,A., Scott,W. K., Gasser,T., Bertram,L., Eriksson,N., Foroud,T., Singleton,A. B., (IPDGC),International Parkinson's Disease Genomics Consortium, (PROGENI),Parkinson's Study Group (PSG) Parkinson's Research: The Organized GENetics Initiative, 23andMe, GenePD, (NGRC),NeuroGenetics Research Consortium, (HIHG),Hussman Institute of Human Genomics, Investigator,Ashkenazi Jewish Dataset, (CHARGE),Cohorts for Health and Aging Research in Genetic Epidemiology, (NABEC),North American Brain Expression Consortium, (UKBEC),United Kingdom Brain Expression Consortium, Consortium,Greek Parkinson's Disease, Group,Alzheimer Genetic Analysis 2014. Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson';s disease Nat Genet, 46 9, 989Stocchi,F., investigators,ADAGIO 2014. Benefits of treatment with rasagiline for fatigue symptoms in patients with early Parkinson';s disease Eur J Neurol, 21 2, 357Evidente,V. G., Fernandez,H. H., LeDoux,M. S., Brashear,A., Grafe,S., Hanschmann,A., Comella,C. L. 2013. A randomized, double-blind study of repeated incobotulinumtoxinA (Xeomin(®)) in cervical dystonia J Neural Transm, 120 12, 1699Fernandez,H. H., Pappert,E. J., Comella,C. L., Evidente,V. G., Truong,D. D., Verma,A., Jankovic,J. 2013. Efficacy and Safety of IncobotulinumtoxinA in Subjects Previously Treated with Botulinum Toxin Versus Toxin-Naïve Subjects with Cervical Dystonia Tremor Other Hyperkinet Mov (N Y), 3 , Group,Parkinson Study 2013. Phase II safety, tolerability, and dose selection study of isradipine as a potential disease-modifying intervention in early Parkinson';s disease (STEADY-PD) Mov Disord, 28 13, 1823Truong,D. D., Gollomp,S. M., Jankovic,J., LeWitt,P. A., Marx,M., Hanschmann,A., Fernandez,H. H., Group,Xeomin US Blepharospasm Study 2013. Sustained efficacy and safety of repeated incobotulinumtoxinA (Xeomin(®)) injections in blepharospasm J Neural Transm, 120 9, 1345Pankratz,N., Beecham,G. W., DeStefano,A. L., Dawson,T. M., Doheny,K. F., Factor,S. A., Hamza,T. H., Hung,A. Y., Hyman,B. T., Ivinson,A. J., Krainc,D., Latourelle,J. C., Clark,L. N., Marder,K., Martin,E. R., Mayeux,R., Ross,O. A., Scherzer,C. R., Simon,D. K., Tanner,C., Vance,J. M., Wszolek,Z. K., Zabetian,C. P., Myers,R. H., Payami,H., Scott,W. K., Foroud,T., Consortium,PD GWAS 2012. Meta-analysis of Parkinson';s disease: identification of a novel locus, RIT2 Ann Neurol, 71 3, 370Comella,C. L., Jankovic,J., Truong,D. D., Hanschmann,A., Grafe,S., Group,U. S. XEOMIN Cervical Dystonia Study 2011. Efficacy and safety of incobotulinumtoxinA (NT 201, XEOMIN®, botulinum neurotoxin type A, without accessory proteins) in patients with cervical dystonia J Neurol Sci, 308 1-2, 103Espay,A. J., Dwivedi,A. K., Payne,M., Gaines,L., Vaughan,J. E., Maddux,B. N., Slevin,J. T., Gartner,M., Sahay,A., Revilla,F. J., Duker,A. P., Shukla,R. 2011. Methylphenidate for gait impairment in Parkinson disease A randomized clinical trial Neurology, 76 14, 1256Espay,Alberto J., Giuffrida,Joe P., Chen,Robert, Payne,Megan, Mazzella,Filomena, Dunn,Emily, Vaughan,Jennifer E., Duker,Andrew P., Sahay,Alok, Kim,Sang Jin, Revilla,Fredy J., Heldman,Dustin A. 2011. Differential response of speed, amplitude, and rhythm to dopaminergic medications in Parkinson';s disease Movement Disorders, 26 14, 2504Espay,Alberto J., Vaughan,Jennifer E., Shukla,Rakesh, Gartner,Maureen, Sahay,Alok, Revilla,Fredy J., Duker,Andrew P. 2011. Botulinum Toxin Type A for Levodopa-Induced Cervical Dyskinesias in Parkinson';s Disease: Unfavorable Risk-Benefit Ratio Movement Disorders, 26 5, 913Heldman,Dustin A., Giuffrida,Joseph P., Chen,Robert, Payne,Megan, Mazzella,Filomena, Duker,Andrew P., Sahay,Alok, Kim,Sang Jin, Revilla,Fredy J., Espay,Alberto J. 2011. The Modified Bradykinesia Rating Scale for Parkinson';s Disease: Reliability and Comparison with Kinematic Measures Movement Disorders, 26 10, 1859Kieburtz,Karl, Parkinson Study Grp Prami,B. I. D. 2011. Twice-Daily, Low-Dose Pramipexole in Early Parkinson';s Disease: A Randomized, Placebo-Controlled Trial Movement Disorders, 26 1, 37Marras,Connie, McDermott,Michael P., Marek,Ken, Rochon,Paula, Naglie,Gary, Tanner,Caroline M., Rudolph,Alice, Shoulson,Ira, Lang,Anthony E., Parkinson Study Grp,Datatop Invest, Parkinson Study Grp,Precept Invest 2011. Predictors of Time to Requiring Dopaminergic Treatment in 2 Parkinson';s Disease Cohorts Movement Disorders, 26 4, 608Pankratz,N., Dumitriu,A., Hetrick,K. N., Sun,M., Latourelle,J. C., Wilk,J. B., Halter,C., Doheny,K. F., Gusella,J. F., Nichols,W. C., Myers,R. H., Foroud,T., DeStefano,A. L., PSG-PROGENI and GenePD Investigators,C.ordinators and Molecular Genetic Laboratories 2011. Copy number variation in familial Parkinson disease PLoS One, 6 8, e20988Schwarzschild,Michael A., Marek,Kenneth, Eberly,Shirley, Oakes,David, Shoulson,Ira, Jennings,Danna, Seibyl,John, Ascherio,Alberto, Parkinson Study Grp,Precept 2011. Serum Urate and Probability of Dopaminergic Deficit in Early "Parkinson';s Disease" Movement Disorders, 26 10, 1864Schwid,Steven R., Bausch,Janice, Oakes,David, Schuchter,Lynn, Tanner,Caroline, Forrest,Misser, Lang,Anthony E., Shoulson,Ira, Investigators,Psg Precept 2010. Cancer Incidence in a Trial of an Antiapoptotic Agent for Parkinson';s Disease Movement Disorders, 25 12, 1801Simon,David K., Pankratz,Nathan, Kissell,Diane K., Pauciulo,Michael W., Halter,Cheryl A., Rudolph,Alice, Pfeiffer,Ronald F., Nichols,William C., Foroud,Tatiana, Parkinson Study Grp,Progeni Invest 2010. Maternal inheritance and mitochondrial DNA variants in familial Parkinson';s disease Bmc Medical Genetics, 11 , Watts,R. L., Lyons,K. E., Pahwa,R., Sethi,K., Stern,M., Hauser,R. A., Olanow,W., Gray,A. M., Adams,B., Earl,N. L., Investigators,228 Study 2010. Onset of dyskinesia with adjunct ropinirole prolonged-release or additional levodopa in early Parkinson';s disease Mov Disord, 25 7, 858Latourelle,J. C., Pankratz,N., Dumitriu,A., Wilk,J. B., Goldwurm,S., Pezzoli,G., Mariani,C. B., DeStefano,A. L., Halter,C., Gusella,J. F., Nichols,W. C., Myers,R. H., Foroud,T., PROGENI Investigators,C.ordinators and Molecular Genetic Laboratories, GenePD Investigators,C.ordinators and Molecular Genetic Laboratories 2009. Genomewide association study for onset age in Parkinson disease BMC Med Genet, 10 , 98Marras,Connie, Lang,Anthony E., Eberly,Shirley W., Oakes,David, Fahn,Stanley, Schwid,Steven R., Hyson,Christopher, Shoulson,Ira, Parkinson Study Grp,Datatop Precep 2009. A Comparison of Treatment Thresholds in Two Large Parkinson';s Disease Clinical Trial Cohorts Movement Disorders, 24 16, 2370Nichols,W. C., Kissell,D. K., Pankratz,N., Pauciulo,M. W., Elsaesser,V. E., Clark,K. A., Halter,C. A., Rudolph,A., Wojcieszek,J., Pfeiffer,R. F., Foroud,T., Parkinson Study Grp,Progeni Invest 2009. Variation in GIGYF2 is not associated with Parkinson disease Neurology, 72 22, 1886Nichols,W. C., Pankratz,N., Marek,D. K., Pauciulo,M. W., Elsaesser,V. E., Halter,C. A., Rudolph,A., Wojcieszek,J., Pfeiffer,R. F., Foroud,T., Parkinson Study Grp,Progeni 2009. Mutations in GBA are associated with familial Parkinson disease susceptibility and age at onset Neurology, 72 4, 310Olanow,C. W., Rascol,O., Hauser,R., Feigin,P. D., Jankovic,J., Lang,A., Langston,W., Melamed,E., Poewe,W., Stocchi,F., Tolosa,E., Investigators,ADAGIO Study 2009. A double-blind, delayed-start trial of rasagiline in Parkinson';s disease N Engl J Med, 361 13, 1268Pankratz,N., Kissell,D. K., Pauciulo,M. W., Halter,C. A., Rudolph,A., Pfeiffer,R. F., Marder,K. S., Foroud,T., Nichols,W. C., Parkinson Study Grp,Progeni Invest 2009. Parkin dosage mutations have greater pathogenicity in familial PD than simple sequence mutations Neurology, 73 4, 279Pankratz,N., Wilk,J. B., Latourelle,J. C., DeStefano,A. L., Halter,C., Pugh,E. W., Doheny,K. F., Gusella,J. F., Nichols,W. C., Foroud,T., Myers,R. H., PSG-PROGENI and GenePD Investigators,C.ordinators and Molecular Genetic Laboratories 2009. Genomewide association study for susceptibility genes contributing to familial Parkinson disease Hum Genet, 124 6, 593Pankratz,Nathan, Nichols,William C., Elsaesser,Veronika E., Pauciulo,Michael W., Marek,Diane K., Halter,Cheryl A., Wojcieszek,Joanne, Rudolph,Alice, Pfeiffer,Ronald F., Foroud,Tatiana, Parkinson Study Grp,Progeni Invest 2009. Alpha-Synuclein and Familial Parkinson';s Disease Movement Disorders, 24 8, 1125Pankratz,N., Marder,K. S., Halter,C. A., Rudolph,A., Shults,C. W., Nichols,W. C., Foroud,T., Investigators,Parkinson's Study Group-PROGENI 2008. Clinical correlates of depressive symptoms in familial Parkinson';s disease Mov Disord, 23 15, 2216Schwarzschild,M. A., Schwid,S. R., Marek,K., Watts,A., Lang,A. E., Oakes,D., Shoulson,I., Ascherio,A., Hyson,C., Gorbold,E., Rudolph,A., Kieburtz,K., Fahn,S., Gauger,L., Goetz,C., Seibyl,J., Forrest,M., Ondrasik,J., Investigators,Parkinson Study Group PRECEPT 2008. Serum urate as a predictor of clinical and radiographic progression in Parkinson disease Arch Neurol, 65 6, 716Goetz,C. G., Damier,P., Hicking,C., Laska,E., Müller,T., Olanow,C. W., Rascol,O., Russ,H. 2007. Sarizotan as a treatment for dyskinesias in Parkinson';s disease: a double-blind placebo-controlled trial Mov Disord, 22 2, 179Investigators,Parkinson Study Group PRECEPT 2007. Mixed lineage kinase inhibitor CEP-1347 fails to delay disability in early Parkinson disease Neurology, 69 15, 1480Nichols,W. C., Elsaesser,V. E., Pankratz,N., Pauciulo,M. W., Marek,D. K., Halter,C. A., Rudolph,A., Shults,C. W., Foroud,T., Parkinson Study Grp,Progeni Invest 2007. LRRK2 mutation analysis in Parkinson disease families with evidence of linkage to PARK8 Neurology, 69 18, 1737Nichols,William C., Marek,Diane K., Pauciulo,Michael W., Pankratz,Nathan, Halter,Cheryl A., Rudolph,Alice, Shults,Clifford W., Wojcieszek,Joanne, Foroud,Tatiana, Investigators,Progeni 2007. R1514Q substitution in Lrrk2 is not a pathogenic Parkinson';s disease mutation Movement Disorders, 22 2, 254Blindauer,K., Shoulson,I., Oakes,D., Kieburtz,K., Schwid,S., Fahn,S., Stern,M., Goetz,C., Nutt,J., Plumb,S., Shinaman,A., Truong,D., Pahwa,R., Factor,S., Evans,S., Wojcieszek,J., Belden,J., Adler,C., Lind,M., Panisset,M., Hall,J., Suchowersky,O., Derwent,L., Di Rocco,A., Boyar,K., Ondo,W., Hunter,C., Colcher,A., Aminoff,M., Dowling,G., Outlaw,H., Dalvi,A., Sahay,A., Schwieterman,D., Elmer,L., Weiner,W., Cines,M., Dignon,C., Frucht,S., Benabou,R., Rajput,A., Ewanishin,M., Jennings,D., Stavris,K., Martin,W., McInnes,G., King,P., Feigin,A., Shannon,B., Gordon,M. F., Atchison,P., Mendis,T., Mendis,N., Reich,S., Dunlop,B., Petzinger,G., Armstrong,C., Welsh,M., Pfeiffer,R., Pfeiffer,B., Tuite,P., Calabrese,V., Roberge,P., Jog,M., Horn,C., Blackstone,C., Growdon,J., Tennis,M., Hauser,R., Gauger,L., Stacy,M., Williamson,K., O'Brien,C., Seeberger,L., Judd,D., Demarcaida,A., Belber,S., Perlmutter,J., McGee-Minnich,L., Ramos,C. S., Berrios,L., Bertoni,J., Peterson,C., Marshall,F., Deeley,C., Verhagen,L., Jaglin,J., Koller,W., Lyons,K., Singer,C., Blenke,A., Mark,M., Caputo,D., Tarsy,D., Scollins,L., Thomas,C. A., Rivest,J., Soucy,D., Bausch,J., Brocht,A., Daigneault,S., Eberly,S., Irvine,C., Lindsay,P., Weaver,C., Tariot,P., Cox,C., Leventhal,C., Goren,S., Sayag,N., Scolnik,M., Levy,R., Eyal,E., Salzman,P., Pagano,M., Parkinson Study,Grp 2006. A randomized controlled trial of etilevodopa in patients with Parkinson disease who have motor fluctuations Archives of Neurology, 63 2, 210Pankratz,N., Pauciulo,M. W., Elsaesser,V. E., Marek,D. K., Halter,C. A., Rudolph,A., Shults,C. W., Foroud,T., Nichols,W. C., Investigators,Parkinson Study Group-PROGENI 2006. Mutations in LRRK2 other than G2019S are rare in a north American-based sample of familial Parkinson';s disease Mov Disord, 21 12, 2257Pankratz,Nathan, Pauciulo,Michael W., Elsaesser,Veronika E., Marek,Diane K., Halter,Cheryl A., Wojcieszek,Joanne, Rudolph,Alice, Shults,Clifford W., Foroud,Tatiana, Nichols,William C., Parkinson Study Grp,Progeni Invest 2006. Mutations in DJ-1 are rare in familial Parkinson disease Neuroscience letters, 408 3, 209Schmit,J. M., Riley,M. A., Dalvi,A., Sahay,A., Shear,P. K., Shockley,K. D., Pun,R. Y. 2006. Deterministic center of pressure patterns characterize postural instability in Parkinson';s disease Exp Brain Res, 168 3, 357Strong,J. A., Dalvi,A., Revilla,F. J., Sahay,A., Samaha,F. J., Welge,J. A., Gong,J., Gartner,M., Yue,X., Yu,L. 2006. Genotype and smoking history affect risk of levodopa-induced dyskinesias in Parkinson';s disease Mov Disord, 21 5, 654Yang,T., Lu,A. G., Ran,R. Q., Aronow,B. J., Schorry,E. K., Hopkin,R. J., Gilbert,D. L., Glauser,T. A., Hershey,A. D., Richtand,N. W., Privitera,M., Dalvi,A., Sahay,A., Szaflarski,J. P., Ficker,D. M., Ratner,N., Sharp,F. R. 2004. Human blood genomics: distinct profiles for gender, age and neurofibromatosis type 1 Molecular Brain Research, 132 2, 155
Beal,M. F., Oakes,D., Shoulson,I., Henchcliffe,C., Galpern,W. R., Haas,R., Juncos,J. L., Nutt,J. G., Voss,T. S., Ravina,B., Shults,C. M., Helles,K., Snively,V., Lew,M. F., Griebner,B., Watts,A., Gao,S., Pourcher,E., Bond,L., Kompoliti,K., Agarwal,P., Sia,C., Jog,M., Cole,L., Sultana,M., Kurlan,R., Richard,I., Deeley,C., Waters,C. H., Figueroa,A., Arkun,A., Brodsky,M., Ondo,W. G., Hunter,C. B., Jimenez-Shahed,J., Palao,A., Miyasaki,J. M., So,J., Tetrud,J., Reys,L., Smith,K., Singer,C., Blenke,A., Russell,D. S., Cotto,C., Friedman,J. H., Lannon,M., Zhang,L., Drasby,E., Kumar,R., Subramanian,T., Ford,D. S., Grimes,D. A., Cote,D., Conway,J., Siderowf,A. D., Evatt,M. L., Sommerfeld,B., Lieberman,A. N., Okun,M. S., Rodriguez,R. L., Merritt,S., Swartz,C. L., Martin,W. R., King,P., Stover,N., Guthrie,S., Watts,R. L., Ahmed,A., Fernandez,H. H., Winters,A., Mari,Z., Dawson,T. M., Dunlop,B., Feigin,A. S., Shannon,B., Nirenberg,M. J., Ogg,M., Ellias,S. A., Thomas,C. A., Frei,K., Bodis-Wollner,I., Glazman,S., Mayer,T., Hauser,R. A., Pahwa,R., Langhammer,A., Ranawaya,R., Derwent,L., Sethi,K. D., Farrow,B., Prakash,R., Litvan,I., Robinson,A., Sahay,A., Gartner,M., Hinson,V. K., Markind,S., Pelikan,M., Perlmutter,J. S., Hartlein,J., Molho,E., Evans,S., Adler,C. H., Duffy,A., Lind,M., Elmer,L., Davis,K., Spears,J., Wilson,S., Leehey,M. A., Hermanowicz,N., Niswonger,S., Shill,H. A., Obradov,S., Rajput,A., Cowper,M., Lessig,S., Song,D., Fontaine,D., Zadikoff,C., Williams,K., Blindauer,K. A., Bergholte,J., Propsom,C. S., Stacy,M. A., Field,J., Mihaila,D., Chilton,M., Uc,E. Y., Sieren,J., Simon,D. K., Kraics,L., Silver,A., Boyd,J. T., Hamill,R. W., Ingvoldstad,C., Young,J., Thomas,K., Kostyk,S. K., Wojcieszek,J., Pfeiffer,R. F., Panisset,M., Beland,M., Reich,S. G., Cines,M., Zappala,N., Rivest,J., Zweig,R., Lumina,L. P., Hilliard,C. L., Grill,S., Kellermann,M., Tuite,P., Rolandelli,S., Kang,U. J., Rao,J., Cook,M. M., Severt,L., Boyar,K., Investigators,Parkinson Study Group QE3 2014. A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit JAMA Neurol, 71 5, 543Hauser,R. A., Silver,D., Choudhry,A., Eyal,E., Isaacson,S., investigators,ANDANTE study 2014. Randomized, controlled trial of rasagiline as an add-on to dopamine agonists in Parkinson';s disease Mov Disord, 29 8, 1028Marek,K., Seibyl,J., Eberly,S., Oakes,D., Shoulson,I., Lang,A. E., Hyson,C., Jennings,D., Investigators,Parkinson Study Group PRECEPT 2014. Longitudinal follow-up of SWEDD subjects in the PRECEPT Study Neurology, 82 20, 1791Nalls,M. A., Pankratz,N., Lill,C. M., Do,C. B., Hernandez,D. G., Saad,M., DeStefano,A. L., Kara,E., Bras,J., Sharma,M., Schulte,C., Keller,M. F., Arepalli,S., Letson,C., Edsall,C., Stefansson,H., Liu,X., Pliner,H., Lee,J. H., Cheng,R., Ikram,M. A., Ioannidis,J. P., Hadjigeorgiou,G. M., Bis,J. C., Martinez,M., Perlmutter,J. S., Goate,A., Marder,K., Fiske,B., Sutherland,M., Xiromerisiou,G., Myers,R. H., Clark,L. N., Stefansson,K., Hardy,J. A., Heutink,P., Chen,H., Wood,N. W., Houlden,H., Payami,H., Brice,A., Scott,W. K., Gasser,T., Bertram,L., Eriksson,N., Foroud,T., Singleton,A. B., (IPDGC),International Parkinson's Disease Genomics Consortium, (PROGENI),Parkinson's Study Group (PSG) Parkinson's Research: The Organized GENetics Initiative, 23andMe, GenePD, (NGRC),NeuroGenetics Research Consortium, (HIHG),Hussman Institute of Human Genomics, Investigator,Ashkenazi Jewish Dataset, (CHARGE),Cohorts for Health and Aging Research in Genetic Epidemiology, (NABEC),North American Brain Expression Consortium, (UKBEC),United Kingdom Brain Expression Consortium, Consortium,Greek Parkinson's Disease, Group,Alzheimer Genetic Analysis 2014. Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson';s disease Nat Genet, 46 9, 989Stocchi,F., investigators,ADAGIO 2014. Benefits of treatment with rasagiline for fatigue symptoms in patients with early Parkinson';s disease Eur J Neurol, 21 2, 357Evidente,V. G., Fernandez,H. H., LeDoux,M. S., Brashear,A., Grafe,S., Hanschmann,A., Comella,C. L. 2013. A randomized, double-blind study of repeated incobotulinumtoxinA (Xeomin(®)) in cervical dystonia J Neural Transm, 120 12, 1699Fernandez,H. H., Pappert,E. J., Comella,C. L., Evidente,V. G., Truong,D. D., Verma,A., Jankovic,J. 2013. Efficacy and Safety of IncobotulinumtoxinA in Subjects Previously Treated with Botulinum Toxin Versus Toxin-Naïve Subjects with Cervical Dystonia Tremor Other Hyperkinet Mov (N Y), 3 , Group,Parkinson Study 2013. Phase II safety, tolerability, and dose selection study of isradipine as a potential disease-modifying intervention in early Parkinson';s disease (STEADY-PD) Mov Disord, 28 13, 1823Truong,D. D., Gollomp,S. M., Jankovic,J., LeWitt,P. A., Marx,M., Hanschmann,A., Fernandez,H. H., Group,Xeomin US Blepharospasm Study 2013. Sustained efficacy and safety of repeated incobotulinumtoxinA (Xeomin(®)) injections in blepharospasm J Neural Transm, 120 9, 1345Pankratz,N., Beecham,G. W., DeStefano,A. L., Dawson,T. M., Doheny,K. F., Factor,S. A., Hamza,T. H., Hung,A. Y., Hyman,B. T., Ivinson,A. J., Krainc,D., Latourelle,J. C., Clark,L. N., Marder,K., Martin,E. R., Mayeux,R., Ross,O. A., Scherzer,C. R., Simon,D. K., Tanner,C., Vance,J. M., Wszolek,Z. K., Zabetian,C. P., Myers,R. H., Payami,H., Scott,W. K., Foroud,T., Consortium,PD GWAS 2012. Meta-analysis of Parkinson';s disease: identification of a novel locus, RIT2 Ann Neurol, 71 3, 370Comella,C. L., Jankovic,J., Truong,D. D., Hanschmann,A., Grafe,S., Group,U. S. XEOMIN Cervical Dystonia Study 2011. Efficacy and safety of incobotulinumtoxinA (NT 201, XEOMIN®, botulinum neurotoxin type A, without accessory proteins) in patients with cervical dystonia J Neurol Sci, 308 1-2, 103Espay,A. J., Dwivedi,A. K., Payne,M., Gaines,L., Vaughan,J. E., Maddux,B. N., Slevin,J. T., Gartner,M., Sahay,A., Revilla,F. J., Duker,A. P., Shukla,R. 2011. Methylphenidate for gait impairment in Parkinson disease A randomized clinical trial Neurology, 76 14, 1256Espay,Alberto J., Giuffrida,Joe P., Chen,Robert, Payne,Megan, Mazzella,Filomena, Dunn,Emily, Vaughan,Jennifer E., Duker,Andrew P., Sahay,Alok, Kim,Sang Jin, Revilla,Fredy J., Heldman,Dustin A. 2011. Differential response of speed, amplitude, and rhythm to dopaminergic medications in Parkinson';s disease Movement Disorders, 26 14, 2504Espay,Alberto J., Vaughan,Jennifer E., Shukla,Rakesh, Gartner,Maureen, Sahay,Alok, Revilla,Fredy J., Duker,Andrew P. 2011. Botulinum Toxin Type A for Levodopa-Induced Cervical Dyskinesias in Parkinson';s Disease: Unfavorable Risk-Benefit Ratio Movement Disorders, 26 5, 913Heldman,Dustin A., Giuffrida,Joseph P., Chen,Robert, Payne,Megan, Mazzella,Filomena, Duker,Andrew P., Sahay,Alok, Kim,Sang Jin, Revilla,Fredy J., Espay,Alberto J. 2011. The Modified Bradykinesia Rating Scale for Parkinson';s Disease: Reliability and Comparison with Kinematic Measures Movement Disorders, 26 10, 1859Kieburtz,Karl, Parkinson Study Grp Prami,B. I. D. 2011. Twice-Daily, Low-Dose Pramipexole in Early Parkinson';s Disease: A Randomized, Placebo-Controlled Trial Movement Disorders, 26 1, 37Marras,Connie, McDermott,Michael P., Marek,Ken, Rochon,Paula, Naglie,Gary, Tanner,Caroline M., Rudolph,Alice, Shoulson,Ira, Lang,Anthony E., Parkinson Study Grp,Datatop Invest, Parkinson Study Grp,Precept Invest 2011. Predictors of Time to Requiring Dopaminergic Treatment in 2 Parkinson';s Disease Cohorts Movement Disorders, 26 4, 608Pankratz,N., Dumitriu,A., Hetrick,K. N., Sun,M., Latourelle,J. C., Wilk,J. B., Halter,C., Doheny,K. F., Gusella,J. F., Nichols,W. C., Myers,R. H., Foroud,T., DeStefano,A. L., PSG-PROGENI and GenePD Investigators,C.ordinators and Molecular Genetic Laboratories 2011. Copy number variation in familial Parkinson disease PLoS One, 6 8, e20988Schwarzschild,Michael A., Marek,Kenneth, Eberly,Shirley, Oakes,David, Shoulson,Ira, Jennings,Danna, Seibyl,John, Ascherio,Alberto, Parkinson Study Grp,Precept 2011. Serum Urate and Probability of Dopaminergic Deficit in Early "Parkinson';s Disease" Movement Disorders, 26 10, 1864Schwid,Steven R., Bausch,Janice, Oakes,David, Schuchter,Lynn, Tanner,Caroline, Forrest,Misser, Lang,Anthony E., Shoulson,Ira, Investigators,Psg Precept 2010. Cancer Incidence in a Trial of an Antiapoptotic Agent for Parkinson';s Disease Movement Disorders, 25 12, 1801Simon,David K., Pankratz,Nathan, Kissell,Diane K., Pauciulo,Michael W., Halter,Cheryl A., Rudolph,Alice, Pfeiffer,Ronald F., Nichols,William C., Foroud,Tatiana, Parkinson Study Grp,Progeni Invest 2010. Maternal inheritance and mitochondrial DNA variants in familial Parkinson';s disease Bmc Medical Genetics, 11 , Watts,R. L., Lyons,K. E., Pahwa,R., Sethi,K., Stern,M., Hauser,R. A., Olanow,W., Gray,A. M., Adams,B., Earl,N. L., Investigators,228 Study 2010. Onset of dyskinesia with adjunct ropinirole prolonged-release or additional levodopa in early Parkinson';s disease Mov Disord, 25 7, 858Latourelle,J. C., Pankratz,N., Dumitriu,A., Wilk,J. B., Goldwurm,S., Pezzoli,G., Mariani,C. B., DeStefano,A. L., Halter,C., Gusella,J. F., Nichols,W. C., Myers,R. H., Foroud,T., PROGENI Investigators,C.ordinators and Molecular Genetic Laboratories, GenePD Investigators,C.ordinators and Molecular Genetic Laboratories 2009. Genomewide association study for onset age in Parkinson disease BMC Med Genet, 10 , 98Marras,Connie, Lang,Anthony E., Eberly,Shirley W., Oakes,David, Fahn,Stanley, Schwid,Steven R., Hyson,Christopher, Shoulson,Ira, Parkinson Study Grp,Datatop Precep 2009. A Comparison of Treatment Thresholds in Two Large Parkinson';s Disease Clinical Trial Cohorts Movement Disorders, 24 16, 2370Nichols,W. C., Kissell,D. K., Pankratz,N., Pauciulo,M. W., Elsaesser,V. E., Clark,K. A., Halter,C. A., Rudolph,A., Wojcieszek,J., Pfeiffer,R. F., Foroud,T., Parkinson Study Grp,Progeni Invest 2009. Variation in GIGYF2 is not associated with Parkinson disease Neurology, 72 22, 1886Nichols,W. C., Pankratz,N., Marek,D. K., Pauciulo,M. W., Elsaesser,V. E., Halter,C. A., Rudolph,A., Wojcieszek,J., Pfeiffer,R. F., Foroud,T., Parkinson Study Grp,Progeni 2009. Mutations in GBA are associated with familial Parkinson disease susceptibility and age at onset Neurology, 72 4, 310Olanow,C. W., Rascol,O., Hauser,R., Feigin,P. D., Jankovic,J., Lang,A., Langston,W., Melamed,E., Poewe,W., Stocchi,F., Tolosa,E., Investigators,ADAGIO Study 2009. A double-blind, delayed-start trial of rasagiline in Parkinson';s disease N Engl J Med, 361 13, 1268Pankratz,N., Kissell,D. K., Pauciulo,M. W., Halter,C. A., Rudolph,A., Pfeiffer,R. F., Marder,K. S., Foroud,T., Nichols,W. C., Parkinson Study Grp,Progeni Invest 2009. Parkin dosage mutations have greater pathogenicity in familial PD than simple sequence mutations Neurology, 73 4, 279Pankratz,N., Wilk,J. B., Latourelle,J. C., DeStefano,A. L., Halter,C., Pugh,E. W., Doheny,K. F., Gusella,J. F., Nichols,W. C., Foroud,T., Myers,R. H., PSG-PROGENI and GenePD Investigators,C.ordinators and Molecular Genetic Laboratories 2009. Genomewide association study for susceptibility genes contributing to familial Parkinson disease Hum Genet, 124 6, 593Pankratz,Nathan, Nichols,William C., Elsaesser,Veronika E., Pauciulo,Michael W., Marek,Diane K., Halter,Cheryl A., Wojcieszek,Joanne, Rudolph,Alice, Pfeiffer,Ronald F., Foroud,Tatiana, Parkinson Study Grp,Progeni Invest 2009. Alpha-Synuclein and Familial Parkinson';s Disease Movement Disorders, 24 8, 1125Pankratz,N., Marder,K. S., Halter,C. A., Rudolph,A., Shults,C. W., Nichols,W. C., Foroud,T., Investigators,Parkinson's Study Group-PROGENI 2008. Clinical correlates of depressive symptoms in familial Parkinson';s disease Mov Disord, 23 15, 2216Schwarzschild,M. A., Schwid,S. R., Marek,K., Watts,A., Lang,A. E., Oakes,D., Shoulson,I., Ascherio,A., Hyson,C., Gorbold,E., Rudolph,A., Kieburtz,K., Fahn,S., Gauger,L., Goetz,C., Seibyl,J., Forrest,M., Ondrasik,J., Investigators,Parkinson Study Group PRECEPT 2008. Serum urate as a predictor of clinical and radiographic progression in Parkinson disease Arch Neurol, 65 6, 716Goetz,C. G., Damier,P., Hicking,C., Laska,E., Müller,T., Olanow,C. W., Rascol,O., Russ,H. 2007. Sarizotan as a treatment for dyskinesias in Parkinson';s disease: a double-blind placebo-controlled trial Mov Disord, 22 2, 179Investigators,Parkinson Study Group PRECEPT 2007. Mixed lineage kinase inhibitor CEP-1347 fails to delay disability in early Parkinson disease Neurology, 69 15, 1480Nichols,W. C., Elsaesser,V. E., Pankratz,N., Pauciulo,M. W., Marek,D. K., Halter,C. A., Rudolph,A., Shults,C. W., Foroud,T., Parkinson Study Grp,Progeni Invest 2007. LRRK2 mutation analysis in Parkinson disease families with evidence of linkage to PARK8 Neurology, 69 18, 1737Nichols,William C., Marek,Diane K., Pauciulo,Michael W., Pankratz,Nathan, Halter,Cheryl A., Rudolph,Alice, Shults,Clifford W., Wojcieszek,Joanne, Foroud,Tatiana, Investigators,Progeni 2007. R1514Q substitution in Lrrk2 is not a pathogenic Parkinson';s disease mutation Movement Disorders, 22 2, 254Blindauer,K., Shoulson,I., Oakes,D., Kieburtz,K., Schwid,S., Fahn,S., Stern,M., Goetz,C., Nutt,J., Plumb,S., Shinaman,A., Truong,D., Pahwa,R., Factor,S., Evans,S., Wojcieszek,J., Belden,J., Adler,C., Lind,M., Panisset,M., Hall,J., Suchowersky,O., Derwent,L., Di Rocco,A., Boyar,K., Ondo,W., Hunter,C., Colcher,A., Aminoff,M., Dowling,G., Outlaw,H., Dalvi,A., Sahay,A., Schwieterman,D., Elmer,L., Weiner,W., Cines,M., Dignon,C., Frucht,S., Benabou,R., Rajput,A., Ewanishin,M., Jennings,D., Stavris,K., Martin,W., McInnes,G., King,P., Feigin,A., Shannon,B., Gordon,M. F., Atchison,P., Mendis,T., Mendis,N., Reich,S., Dunlop,B., Petzinger,G., Armstrong,C., Welsh,M., Pfeiffer,R., Pfeiffer,B., Tuite,P., Calabrese,V., Roberge,P., Jog,M., Horn,C., Blackstone,C., Growdon,J., Tennis,M., Hauser,R., Gauger,L., Stacy,M., Williamson,K., O'Brien,C., Seeberger,L., Judd,D., Demarcaida,A., Belber,S., Perlmutter,J., McGee-Minnich,L., Ramos,C. S., Berrios,L., Bertoni,J., Peterson,C., Marshall,F., Deeley,C., Verhagen,L., Jaglin,J., Koller,W., Lyons,K., Singer,C., Blenke,A., Mark,M., Caputo,D., Tarsy,D., Scollins,L., Thomas,C. A., Rivest,J., Soucy,D., Bausch,J., Brocht,A., Daigneault,S., Eberly,S., Irvine,C., Lindsay,P., Weaver,C., Tariot,P., Cox,C., Leventhal,C., Goren,S., Sayag,N., Scolnik,M., Levy,R., Eyal,E., Salzman,P., Pagano,M., Parkinson Study,Grp 2006. A randomized controlled trial of etilevodopa in patients with Parkinson disease who have motor fluctuations Archives of Neurology, 63 2, 210Pankratz,N., Pauciulo,M. W., Elsaesser,V. E., Marek,D. K., Halter,C. A., Rudolph,A., Shults,C. W., Foroud,T., Nichols,W. C., Investigators,Parkinson Study Group-PROGENI 2006. Mutations in LRRK2 other than G2019S are rare in a north American-based sample of familial Parkinson';s disease Mov Disord, 21 12, 2257Pankratz,Nathan, Pauciulo,Michael W., Elsaesser,Veronika E., Marek,Diane K., Halter,Cheryl A., Wojcieszek,Joanne, Rudolph,Alice, Shults,Clifford W., Foroud,Tatiana, Nichols,William C., Parkinson Study Grp,Progeni Invest 2006. Mutations in DJ-1 are rare in familial Parkinson disease Neuroscience letters, 408 3, 209Schmit,J. M., Riley,M. A., Dalvi,A., Sahay,A., Shear,P. K., Shockley,K. D., Pun,R. Y. 2006. Deterministic center of pressure patterns characterize postural instability in Parkinson';s disease Exp Brain Res, 168 3, 357Strong,J. A., Dalvi,A., Revilla,F. J., Sahay,A., Samaha,F. J., Welge,J. A., Gong,J., Gartner,M., Yue,X., Yu,L. 2006. Genotype and smoking history affect risk of levodopa-induced dyskinesias in Parkinson';s disease Mov Disord, 21 5, 654Yang,T., Lu,A. G., Ran,R. Q., Aronow,B. J., Schorry,E. K., Hopkin,R. J., Gilbert,D. L., Glauser,T. A., Hershey,A. D., Richtand,N. W., Privitera,M., Dalvi,A., Sahay,A., Szaflarski,J. P., Ficker,D. M., Ratner,N., Sharp,F. R. 2004. Human blood genomics: distinct profiles for gender, age and neurofibromatosis type 1 Molecular Brain Research, 132 2, 155