Contact Information Childrens Hospital Bldg R 7501 Office 513-636-0595 Email zhengyi@ucmail.uc.edu Peer Reviewed Publications Zhang, Dongsheng; Tang, Wenjuan; Niu, Haitao; Tse, William; Ruan, Hai-Bin; Dolznig, Helmut; Knösel, Thomas; Karl-Heinz, Friedrich; Themanns, Madeleine; Wang, Jiang; Song, Mingquan; Denson, Lee; Kenner, Lukas; Moriggl, Richard; Zheng, Yi; Han, Xiaonan 2024. Monogenic deficiency in murine intestinal Cdc42 leads to mucosal inflammation that induces crypt dysplasia. Genes & diseases, 11 1, 413-429Dandamudi, Akhila; Akbar, Huzoor; Cancelas, Jose; Zheng, Yi 2023. Rho GTPase Signaling in Platelet Regulation and Implication for Antiplatelet Therapies. International journal of molecular sciences, 24 3, Dandamudi, Akhila; Seibel, William; Tourdot, Benjamin; Cancelas, Jose A; Akbar, Huzoor; Zheng, Yi 2023. Structure-Activity Relationship Analysis of Rhosin, a RhoA GTPase Inhibitor, Reveals a New Class of Antiplatelet Agents. International journal of molecular sciences, 24 4, Fan, Cuiqing; Wunderlich, Mark; Cai, Xiongwei; Yan, Zijun; Zhang, Feng; Davis, Ashley Kuenzi; Xu, Lingli; Guo, Fukun; Lu, Q Richard; Azam, Mohammad; Tian, Weidong; Zheng, Yi 2023. Kinase-independent role of mTOR and on-/off-target effects of an mTOR kinase inhibitor. Leukemia, 37 10, 2073-2081Katayama, Kei-Ichi; Zheng, Yi; Inoue, Norimitsu 2023. Rac is required for the survival of cortical neurons. Experimental neurology, 361 , 114316Li, Yuehuan; Martin, Taylor Elijah; Hancock, Jonathan Matthew; Li, Rong; Viswanathan, Suvitha; Lydon, John P; Zheng, Yi; Ye, Xiaoqin 2023. Visualization of preimplantation uterine fluid absorption in mice using Alexa Fluor™ 488 Hydrazide†. Biology of reproduction, 108 2, 204-217Modur, Vishnu; Muhammad, Belal; Yang, Jun-Qi; Zheng, Yi; Komurov, Kakajan; Guo, Fukun 2023. Mechanism of inert inflammation in an immune checkpoint blockade-resistant tumor subtype bearing transcription elongation defects. Cell reports, 42 4, 112364Wang, Chen; Tu, Zhaowei; Cai, Xiongwei; Wang, Weinan; Davis, Ashely K; Nattamai, Kalpana; Paranjpe, Aditi; Dexheimer, Philip; Wu, Jianqiang; Huang, Frank Lei; Geiger, Hartmut; Huang, Gang; Zheng, Yi 2023. A critical role of RUNX1 in governing megakaryocyte-primed hematopoietic stem cell differentiation. Blood advances, 7 11, 2590-2605Zhang, Cuiping; Cui, Xiaojing; Liu, Yi; Wang, Fang; Signer, Robert; Nattamai, Kapana; Zhou, Daohong; Zheng, Yi; Geiger, Hartmut; Wan, Fengyi; Liang, Ying 2023. Latexin deletion protects against radiation-induced hematopoietic damages via selective activation of Bcl-2 prosurvival pathway. Haematologica, 108 12, 3464-3470Akwii, Racheal Grace; Sajib, Md Sanaullah; Zahra, Fatema Tuz; Tullar, Paul; Zabet-Moghaddam, Masoud; Zheng, Yi; Silvio Gutkind, J; Doci, Colleen L; Mikelis, Constantinos M 2022. Angiopoietin-2-induced lymphatic endothelial cell migration drives lymphangiogenesis via the β1 integrin-RhoA-formin axis. Angiogenesis, 25 3, 373-396Amoah, Amanda; Keller, Anja; Emini, Ramiz; Hoenicka, Markus; Liebold, Andreas; Vollmer, Angelika; Eiwen, Karina; Soller, Karin; Sakk, Vadim; Zheng, Yi; Florian, Maria Carolina; Geiger, Hartmut 2022. Aging of human hematopoietic stem cells is linked to changes in Cdc42 activity. Haematologica, 107 2, 393-402Hegde, Shailaja; Gasilina, Anjelika; Wunderlich, Mark; Lin, Yuan; Buchholzer, Marcel; Krumbach, Oliver H F; Akbarzadeh, Mohammad; Ahmadian, Mohammad Reza; Seibel, William; Zheng, Yi; Perentesis, John P; Mizukawa, Benjamin E; Vinnedge, Lisa Privette; Cancelas, José A; Nassar, Nicolas N 2022. Inhibition of the RacGEF VAV3 by the small molecule IODVA1 impedes RAC signaling and overcomes resistance to tyrosine kinase inhibition in acute lymphoblastic leukemia. Leukemia, 36 3, 637-647Hegde, Shailaja; Zheng, Yi; Cancelas, Jose A 2022. Novel blood derived hemostatic agents for bleeding therapy and prophylaxis. Current opinion in hematology, 29 6, 281-289Kalim, Khalid W; Yang, Jun-Qi; Wunderlich, Mark; Modur, Vishnu; Nguyen, Phuong; Li, Yuan; Wen, Ting; Davis, Ashley Kuenzi; Verma, Ravinder; Lu, Qing Richard; Jegga, Anil G; Zheng, Yi; Guo, Fukun 2022. Targeting of Cdc42 GTPase in regulatory T cells unleashes antitumor T-cell immunity. Journal for immunotherapy of cancer, 10 11, Katayama, Kei-Ichi; Zheng, Yi; Inoue, Norimitsu 2022. Rac-deficient cerebellar granule neurons die before they migrate to the internal granule layer. Scientific reports, 12 1, 14848Kim, Kee-Beom; Kim, Dong-Wook; Kim, Youngchul; Tang, Jun; Kirk, Nicole; Gan, Yongyu; Kim, Bongjun; Fang, Bingliang; Park, Jae-Ll; Zheng, Yi; Park, Kwon-Sik 2022. WNT5A-RHOA Signaling Is a Driver of Tumorigenesis and Represents a Therapeutically Actionable Vulnerability in Small Cell Lung Cancer. Cancer research, 82 22, 4219-4233Kim, Young-Woong; Zara, Greta; Kang, HyunJun; Branciamore, Sergio; O'Meally, Denis; Feng, Yuxin; Kuan, Chia-Yi; Luo, Yingjun; Nelson, Michael S; Brummer, Alex B; Rockne, Russell; Chen, Zhen Bouman; Zheng, Yi; Cardoso, Angelo A; Carlesso, Nadia 2022. Integration of single-cell transcriptomes and biological function reveals distinct behavioral patterns in bone marrow endothelium. Nature communications, 13 1, 7235Montserrat-Vazquez, Sara; Ali, Noelle J; Matteini, Francesca; Lozano, Javier; Zhaowei, Tu; Mejia-Ramirez, Eva; Marka, Gina; Vollmer, Angelika; Soller, Karin; Sacma, Mehmet; Sakk, Vadim; Mularoni, Loris; Mallm, Jan Philipp; Plass, Mireya; Zheng, Yi; Geiger, Hartmut; Florian, M Carolina 2022. Transplanting rejuvenated blood stem cells extends lifespan of aged immunocompromised mice. NPJ Regenerative medicine, 7 1, 78Nalapareddy, Kodandaramireddy; Zheng, Yi; Geiger, Hartmut 2022. Aging of intestinal stem cells. Stem cell reports, 17 4, 734-740Romano, Laurel; Seu, Katie G; Papoin, Julien; Muench, David E; Konstantinidis, Diamantis; Olsson, André; Schlum, Katrina; Chetal, Kashish; Chasis, Joel Anne; Mohandas, Narla; Barnes, Betsy J; Zheng, Yi; Grimes, H Leighton; Salomonis, Nathan; Blanc, Lionel; Kalfa, Theodosia A 2022. Erythroblastic islands foster granulopoiesis in parallel to terminal erythropoiesis. Blood, 140 14, 1621-1634Tu, Zhaowei; Fan, Cuiqing; Davis, Ashely K; Hu, Mengwen; Wang, Chen; Dandamudi, Akhila; Seu, Katie G; Kalfa, Theodosia A; Lu, Q Richard; Zheng, Yi 2022. Autism-associated chromatin remodeler CHD8 regulates erythroblast cytokinesis and fine-tunes the balance of Rho GTPase signaling. Cell reports, 40 2, 111072Tu, Zhaowei; Zheng, Yi 2022. Role of ATP-dependent chromatin remodelers in hematopoietic stem and progenitor cell maintenance. Current opinion in hematology, 29 4, 174-180Zhang, Zheng; Zhang, Feng; Davis, Ashley Kuenzi; Xin, Mei; Walz, Gerd; Tian, Weidong; Zheng, Yi 2022. CDC42 controlled apical-basal polarity regulates intestinal stem cell to transit amplifying cell fate transition via YAP-EGF-mTOR signaling. Cell reports, 38 2, 110009Chlon, Timothy M; Stepanchick, Emily; Hershberger, Courtney E; Daniels, Noah J; Hueneman, Kathleen M; Kuenzi Davis, Ashley; Choi, Kwangmin; Zheng, Yi; Gurnari, Carmelo; Haferlach, Torsten; Padgett, Richard A; Maciejewski, Jaroslaw P; Starczynowski, Daniel T 2021. Germline DDX41 mutations cause ineffective hematopoiesis and myelodysplasia. Cell stem cell, 28 11, 1966-1981.e6Duan, Xin; Perveen, Rehana; Dandamudi, Akhila; Adili, Reheman; Johnson, James; Funk, Kevin; Berryman, Mark; Davis, Ashley Kuenzi; Holinstat, Michael; Zheng, Yi; Akbar, Huzoor 2021. Pharmacologic targeting of Cdc42 GTPase by a small molecule Cdc42 activity-specific inhibitor prevents platelet activation and thrombosis. Scientific reports, 11 1, 13170Fan, Cuiqing; Zhao, Chuntao; Zhang, Feng; Kesarwani, Meenu; Tu, Zhaowei; Cai, Xiongwei; Davis, Ashley Kuenzi; Xu, Lingli; Hochstetler, Cindy L; Chen, Xiaoyi; Guo, Fukun; Huang, Gang; Azam, Mohammad; Tian, Weidong; Lu, Q Richard; Zheng, Yi 2021. Adaptive responses to mTOR gene targeting in hematopoietic stem cells reveal a proliferative mechanism evasive to mTOR inhibition. Proceedings of the National Academy of Sciences of the United States of America, 118 1, Fan, Yuping; Teng, Yan; Loison, Fabien; Pang, Aiming; Kasorn, Anongnard; Shao, Xinqi; Zhang, Cunling; Ren, Qian; Yu, Hongbo; Zheng, Yi; Cancelas, Jose A; Manis, John; Chai, Li; Park, Shin-Young; Zhao, Li; Xu, Yuanfu; Feng, Sizhou; Silberstein, Leslie E; Ma, Fengxia; Luo, Hongbo R 2021. Targeting multiple cell death pathways extends the shelf life and preserves the function of human and mouse neutrophils for transfusion. Science translational medicine, 13 604, Guidi, Novella; Marka, Gina; Sakk, Vadim; Zheng, Yi; Florian, Maria Carolina; Geiger, Hartmut 2021. An aged bone marrow niche restrains rejuvenated hematopoietic stem cells. Stem cells (Dayton, Ohio), 39 8, 1101-1106Hegde, Shailaja; Wellendorf, Ashley M; Zheng, Yi; Cancelas, Jose A 2021. Antioxidant prevents clearance of hemostatically competent platelets after long-term cold storage. Transfusion, 61 2, 557-567Kalim, Khalid W; Yang, Jun-Qi; Modur, Vishnu; Nguyen, Phuong; Li, Yuan; Zheng, Yi; Guo, Fukun 2021. Graded RhoA GTPase Expression in Treg Cells Distinguishes Tumor Immunity From Autoimmunity. Frontiers in immunology, 12 , 726393Kandi, Ravinder; Senger, Katharina; Grigoryan, Ani; Soller, Karin; Sakk, Vadim; Schuster, Tanja; Eiwen, Karina; Menon, Manoj B; Gaestel, Matthias; Zheng, Yi; Florian, Maria Carolina; Geiger, Hartmut 2021. Cdc42-Borg4-Septin7 axis regulates HSC polarity and function. EMBO reports, 22 12, e52931Lin, Yuan; Lu, Shaoyong; Zhang, Jian; Zheng, Yi 2021. Structure of an inactive conformation of GTP-bound RhoA GTPase. Structure (London, England : 1993), 29 6, 553-563.e5Lin, Yuan; Watanabe-Chailland, Miki; Zheng, Yi 2021. Protocol for structural and biochemical analyses of RhoA GTPase. STAR protocols, 2 2, 100541Nakamura, Yuka; Ueno, Masaki; Niehaus, Jesse K; Lang, Richard A; Zheng, Yi; Yoshida, Yutaka 2021. Modulation of Both Intrinsic and Extrinsic Factors Additively Promotes Rewiring of Corticospinal Circuits after Spinal Cord Injury. The Journal of neuroscience : the official journal of the Society for Neuroscience, 41 50, 10247-10260Nalapareddy, Kodandaramireddy; Hassan, Aishlin; Sampson, Leesa L; Zheng, Yi; Geiger, Hartmut 2021. Suppression of elevated Cdc42 activity promotes the regenerative potential of aged intestinal stem cells. iScience, 24 4, 102362Sertorio, Mathieu; Nowrouzi, Ali; Akbarpour, Mahdi; Chetal, Kashish; Salomonis, Nathan; Brons, Stephan; Mascia, Anthony; Ionascu, Dan; McCauley, Shelby; Kupneski, Taylor; Köthe, Andreas; Debus, Jürgen; Perentesis, John P; Abdollahi, Amir; Zheng, Yi; Wells, Susanne I 2021. Differential transcriptome response to proton versus X-ray radiation reveals novel candidate targets for combinatorial PT therapy in lymphoma. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 155 , 293-303Sheng, Yue; Ma, Rui; Yu, Chunjie; Wu, Qiong; Zhang, Steven; Paulsen, Kimberly; Zhang, Jiwang; Ni, Hongyu; Huang, Yong; Zheng, Yi; Qian, Zhijian 2021. Role of c-Myc haploinsufficiency in the maintenance of HSCs in mice. Blood, 137 5, 610-623Tu, Zhaowei; Wang, Chen; Davis, Ashley K; Hu, Mengwen; Zhao, Chuntao; Xin, Mei; Lu, Q Richard; Zheng, Yi 2021. The chromatin remodeler CHD8 governs hematopoietic stem/progenitor survival by regulating ATM-mediated P53 protein stability. Blood, 138 3, 221-233Zhang, Bin; Nguyen, Le Xuan Truong; Zhao, Dandan; Frankhouser, David E; Wang, Huafeng; Hoang, Dinh Hoa; Qiao, Junjing; Abundis, Christina; Brehove, Matthew; Su, Yu-Lin; Feng, Yuxin; Stein, Anthony; Ghoda, Lucy; Dorrance, Adrianne; Perrotti, Danilo; Chen, Zhen; Han, Anjia; Pichiorri, Flavia; Jin, Jie; Jovanovic-Talisman, Tijana; Caligiuri, Michael A; Kuo, Calvin J; Yoshimura, Akihiko; Li, Ling; Rockne, Russell C; Kortylewski, Marcin; Zheng, Yi; Carlesso, Nadia; Kuo, Ya-Huei; Marcucci, Guido 2021. Treatment-induced arteriolar revascularization and miR-126 enhancement in bone marrow niche protect leukemic stem cells in AML. Journal of hematology & oncology, 14 1, 122Zhang, Zheng; Liu, Ming; Zheng, Yi 2021. Role of Rho GTPases in stem cell regulation. Biochemical Society transactions, 49 6, 2941-2955Althoff, Mark; Nayak, Ramesh; Hegde, Shailaja; Wellendorf, Ashley; Bohan, Breanna; Filippi, Marie-Dominique; Xin, Mei; Lu, Richard; Geiger, Hartmut; Zheng, Yi; Diaz-Meco, Maria T; Moscat, Jorge; Cancelas, Jose A 2020. Yap1-Scribble polarization is required for hematopoietic stem cell division and fate. Blood, , Florian, Maria Carolina; Leins, Hanna; Gobs, Michael; Han, Yang; Marka, Gina; Soller, Karin; Vollmer, Angelika; Sakk, Vadim; Nattamai, Kalpana J; Rayes, Ahmad; Zhao, Xueheng; Setchell, Kenneth; Mulaw, Medhanie; Wagner, Wolfgang; Zheng, Yi; Geiger, Hartmut 2020. Inhibition of Cdc42 activity extends lifespan and decreases circulating inflammatory cytokines in aged female C57BL/6 mice. Aging cell, , e13208Muto, Tomoya; Walker, Callum S; Choi, Kwangmin; Hueneman, Kathleen; Smith, Molly A; Gul, Zartash; Garcia-Manero, Guillermo; Ma, Averil; Zheng, Yi; Starczynowski, Daniel T 2020. Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs. Nature immunology, 21 5, 535-545Papaioannou, Dimitrios; Petri, Andreas; Dovey, Oliver M; Terreri, Sara; Wang, Eric; Collins, Frances A; Woodward, Lauren A; Walker, Allison E; Nicolet, Deedra; Pepe, Felice; Kumchala, Prasanthi; Bill, Marius; Walker, Christopher J; Karunasiri, Malith; Mrózek, Krzysztof; Gardner, Miranda L; Camilotto, Virginia; Zitzer, Nina; Cooper, Jonathan L; Cai, Xiongwei; Rong-Mullins, Xiaoqing; Kohlschmidt, Jessica; Archer, Kellie J; Freitas, Michael A; Zheng, Yi; Lee, Robert J; Aifantis, Iannis; Vassiliou, George; Singh, Guramrit; Kauppinen, Sakari; Bloomfield, Clara D; Dorrance, Adrienne M; Garzon, Ramiro 2020. Author Correction: The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia. Nature communications, 11 1, 3878Papaioannou, Dimitrios; Petri, Andreas; Dovey, Oliver M; Terreri, Sara; Wang, Eric; Collins, Frances A; Woodward, Lauren A; Walker, Allison E; Nicolet, Deedra; Pepe, Felice; Kumchala, Prasanthi; Bill, Marius; Walker, Christopher J; Karunasiri, Malith; Mrózek, Krzysztof; Gardner, Miranda L; Camilotto, Virginia; Zitzer, Nina; Cooper, Jonathan L; Cai, Xiongwei; Rong-Mullins, Xiaoqing; Kohlschmidt, Jessica; Archer, Kellie J; Freitas, Michael A; Zheng, Yi; Lee, Robert J; Aifantis, Iannis; Vassiliou, George; Singh, Guramrit; Kauppinen, Sakari; Bloomfield, Clara D; Dorrance, Adrienne M; Garzon, Ramiro 2020. Publisher Correction: The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia. Nature communications, 11 1, 204Sheng, Yue; Ma, Rui; Yu, Chunjie; Wu, Qiong; Zhang, Steven; Paulsen, Kimberly; Zhang, Jiwang; Ni, Hongyu; Huang, Yong; Zheng, Yi; Qian, Zhijian 2020. Role of c-Myc haploinsufficiency in the maintenance of HSCs. Blood, , Sheng, Yue; Ma, Rui; Yu, Chunjie; Wu, Qiong; Zhang, Steven; Paulsen, Kimberly; Zhang, Jiwang; Ni, Hongyu; Huang, Yong; Zheng, Yi; Qian, Zhijian 2020. Role of c-Myc haploinsufficiency in the maintenance of HSCs. Blood, , Hochstetler, Cindy L; Feng, Yuxin; Sacma, Mehmet; Davis, Ashley K; Rao, Mahil; Kuan, Chia-Yi; You, Li-Ru; Geiger, Hartmut; Zheng, Yi 2019. KRasG12D expression in the bone marrow vascular niche affects hematopoiesis with inflammatory signals. Experimental hematology, , Nayak, R C; Hegde, S; Althoff, M J; Wellendorf, A M; Mohmoud, F; Perentesis, J; Reina-Campos, M; Reynaud, D; Zheng, Y; Diaz-Meco, M T; Moscat, J; Cancelas, J A 2019. The signaling axis atypical protein kinase C ?/?-Satb2 mediates leukemic transformation of B-cell progenitors. Nature communications, 10 1, 46Nguyen, Phuong; Chakrabarti, Jayati; Li, Yuan; Kalim, Khalid W; Zhang, Mengnan; Zhang, Lin; Zheng, Yi; Guo, Fukun 2019. Rational Targeting of Cdc42 Overcomes Drug Resistance of Multiple Myeloma. Frontiers in oncology, 9 , 958Papaioannou, Dimitrios; Petri, Andreas; Dovey, Oliver M; Terreri, Sara; Wang, Eric; Collins, Frances A; Woodward, Lauren A; Walker, Allison E; Nicolet, Deedra; Pepe, Felice; Kumchala, Prasanthi; Bill, Marius; Walker, Christopher J; Karunasiri, Malith; Mrózek, Krzysztof; Gardner, Miranda L; Camilotto, Virginia; Zitzer, Nina; Cooper, Jonathan L; Cai, Xiongwei; Rong-Mullins, Xiaoqing; Kohlschmidt, Jessica; Archer, Kellie J; Freitas, Michael A; Zheng, Yi; Lee, Robert J; Aifantis, Iannis; Vassiliou, George; Singh, Guramrit; Kauppinen, Sakari; Bloomfield, Clara D; Dorrance, Adrienne M; Garzon, Ramiro 2019. The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia. Nature communications, 10 1, 5351Xie, Yangyang; Gao, Li; Xu, Chunhui; Chu, Liming; Gao, Lei; Wu, Ruichi; Liu, Yu; Liu, Ting; Sun, Xiao-Jian; Ren, Ruibao; Tang, Jingyan; Zheng, Yi; Zhou, Yong; Shen, Shuhong 2019. ARHGEF12 regulates erythropoiesis and is involved in erythroid regeneration after chemotherapy in acute lymphoblastic leukemia patients. Haematologica, , Yang, Jun-Qi; Kalim, Khalid W; Li, Yuan; Duan, Xin; Nguyen, Phuong; Khurana Hershey, Gurjit K; Kroner, John; Ruff, Brandy; Zhang, Li; Salomonis, Nathan; Rochman, Mark; Wen, Ting; Zheng, Yi; Guo, Fukun 2019. Rational targeting Cdc42 restrains Th2 cell differentiation and prevents allergic airway inflammation. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 49 1, 92-107Yang, Jun-Qi; Kalim, Khalid W; Li, Yuan; Zheng, Yi; Guo, Fukun 2019. Ablation of RhoA impairs Th17 cell differentiation and alleviates house dust mite-triggered allergic airway inflammation. Journal of leukocyte biology, , Zahra, Fatema Tuz; Sajib, Md Sanaullah; Ichiyama, Yusuke; Akwii, Racheal Grace; Tullar, Paul E; Cobos, Christopher; Minchew, Shelby A; Doçi, Colleen L; Zheng, Yi; Kubota, Yoshiaki; Gutkind, J Silvio; Mikelis, Constantinos M 2019. Endothelial RhoA GTPase is essential for in vitro endothelial functions but dispensable for physiological in vivo angiogenesis. Scientific reports, 9 1, 11666Zhang, Cuiping; Fondufe-Mittendorf, Yvonne N; Wang, Chi; Chen, Jin; Cheng, Qiang; Zhou, Daohong; Zheng, Yi; Geiger, Hartmut; Liang, Ying 2019. Latexin regulation by HMGB2 is required for hematopoietic stem cell maintenance. Haematologica, , Zhou, Wei; Yang, Yingying; Mei, Congjin; Dong, Panpan; Mu, Shasha; Wu, Hongchu; Zhou, Yonghua; Zheng, Yi; Guo, Fukun; Yang, Jun-Qi 2019. Inhibition of Rho-Kinase Downregulates Th17 Cells and Ameliorates Hepatic Fibrosis by Schistosoma japonicum Infection. Cells, 8 10, Akbar, H; Duan, X; Piatt, R; Saleem, S; Davis, A K; Tandon, N N; Bergmeier, W; Zheng, Y 2018. Small molecule targeting the Rac1-NOX2 interaction prevents collagen-related peptide and thrombin-induced reactive oxygen species generation and platelet activation. Journal of thrombosis and haemostasis : JTH, 16 10, 2083-2096Cai, Xiongwei; Zheng, Yi; Speck, Nancy A 2018. A Western Blotting Protocol for Small Numbers of Hematopoietic Stem Cells. Journal of visualized experiments : JoVE, 138, Cai, Xiongwei; Zhou, Xuan; Zheng, Yi 2018. In Vivo Rescue Assay of RhoA-Deficient Hematopoietic Stem and Progenitor Cells. Methods in molecular biology (Clifton, N.J.), 1821 , 247-256Chadwick, Michelle L; Lane, Adam; Thomas, Dana; Smith, Amanda R; White, Angela R; Davidson, Dominique; Feng, Yuxin; Boscolo, Elisa; Zheng, Yi; Adams, Denise M; Gupta, Anita; Veillette, André; Chow, Lionel M L 2018. Combined mTOR and MEK inhibition is an effective therapy in a novel mouse model for angiosarcoma. Oncotarget, 9 37, 24750-24765Du, Wei; Liu, Wei; Mizukawa, Benjamin; Shang, Xun; Sipple, Jared; Wunderlich, Mark; Geiger, Hartmut; Davies, Stella; Mulloy, James; Pang, Qishen; Zheng, Yi 2018. A non-myeloablative conditioning approach for long-term engraftment of human and mouse hematopoietic stem cells. Leukemia, 32 9, 2041-2046Fang, Jing; Muto, Tomoya; Kleppe, Maria; Bolanos, Lyndsey C; Hueneman, Kathleen M; Walker, Callum S; Sampson, Leesa; Wellendorf, Ashley M; Chetal, Kashish; Choi, Kwangmin; Salomonis, Nathan; Choi, Yongwon; Zheng, Yi; Cancelas, Jose A; Levine, Ross L; Starczynowski, Daniel T 2018. TRAF6 Mediates Basal Activation of NF-?B Necessary for Hematopoietic Stem Cell Homeostasis. Cell reports, 22 5, 1250-1262Florian, M Carolina; Klose, Markus; Sacma, Mehmet; Jablanovic, Jelena; Knudson, Luke; Nattamai, Kalpana J; Marka, Gina; Vollmer, Angelika; Soller, Karin; Sakk, Vadim; Cabezas-Wallscheid, Nina; Zheng, Yi; Mulaw, Medhanie A; Glauche, Ingmar; Geiger, Hartmut 2018. Aging alters the epigenetic asymmetry of HSC division. PLoS biology, 16 9, e2003389Grigoryan, Ani; Guidi, Novella; Senger, Katharina; Liehr, Thomas; Soller, Karin; Marka, Gina; Vollmer, Angelika; Markaki, Yolanda; Leonhardt, Heinrich; Buske, Christian; Lipka, Daniel B; Plass, Christoph; Zheng, Yi; Mulaw, Medhanie A; Geiger, Hartmut; Florian, Maria Carolina 2018. LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells. Genome biology, 19 1, 189Hayashi, Yoshihiro; Zhang, Yue; Yokota, Asumi; Yan, Xiaomei; Liu, Jinqin; Choi, Kwangmin; Li, Bing; Sashida, Goro; Peng, Yanyan; Xu, Zefeng; Huang, Rui; Zhang, Lulu; Freudiger, George M; Wang, Jingya; Dong, Yunzhu; Zhou, Yile; Wang, Jieyu; Wu, Lingyun; Bu, Jiachen; Chen, Aili; Zhao, Xinghui; Sun, Xiujuan; Chetal, Kashish; Olsson, Andre; Watanabe, Miki; Romick-Rosendale, Lindsey E; Harada, Hironori; Shih, Lee-Yung; Tse, William; Bridges, James P; Caligiuri, Michael A; Huang, Taosheng; Zheng, Yi; Witte, David P; Wang, Qian-Fei; Qu, Cheng-Kui; Salomonis, Nathan; Grimes, H Leighton; Nimer, Stephen D; Xiao, Zhijian; Huang, Gang 2018. Pathobiological Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes. Cancer discovery, 8 11, 1438-1457Hegde, Shailaja; Akbar, Huzoor; Zheng, Yi; Cancelas, Jose A 2018. Towards increasing shelf life and haemostatic potency of stored platelet concentrates. Current opinion in hematology, 25 6, 500-508Jiang, Xi; Hu, Chao; Ferchen, Kyle; Nie, Ji; Cui, Xiaolong; Chen, Chih-Hong; Cheng, Liting; Zuo, Zhixiang; Seibel, William; He, Chunjiang; Tang, Yixuan; Skibbe, Jennifer R; Wunderlich, Mark; Reinhold, William C; Dong, Lei; Shen, Chao; Arnovitz, Stephen; Ulrich, Bryan; Lu, Jiuwei; Weng, Hengyou; Su, Rui; Huang, Huilin; Wang, Yungui; Li, Chenying; Qin, Xi; Mulloy, James C; Zheng, Yi; Diao, Jiajie; Jin, Jie; Li, Chong; Liu, Paul P; He, Chuan; Chen, Yuan; Chen, Jianjun 2018. Author Correction: Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia. Nature communications, 9 1, 670Kalim, Khalid W; Yang, Jun-Qi; Li, Yuan; Meng, Yan; Zheng, Yi; Guo, Fukun 2018. Reciprocal Regulation of Glycolysis-Driven Th17 Pathogenicity and Regulatory T Cell Stability by Cdc42. Journal of immunology (Baltimore, Md. : 1950), 200 7, 2313-2326Liu, Wei; Du, Wei; Shang, Xun; Wang, Lei; Evelyn, Chris; Florian, Maria Carolina; A Ryan, Marnie; Rayes, Ahmad; Zhao, Xueheng; Setchell, Kenneth; Meller, Jarek; Guo, Fukun; Nassar, Nicolas; Geiger, Hartmut; Pang, Qishen; Zheng, Yi 2018. Rational identification of a Cdc42 inhibitor presents a new regimen for long-term hematopoietic stem cell mobilization. Leukemia, , Lv, Jiawen; Zeng, Junchao; Guo, Fukun; Li, Yiran; Xu, Mengying; Cheng, Yuanxiong; Zhang, Lin; Cai, Shaoxi; Chen, Yinghua; Zheng, Yi; Hu, Guodong 2018. Endothelial Cdc42 deficiency impairs endothelial regeneration and vascular repair after inflammatory vascular injury. Respiratory research, 19 1, 27Maliken, Bryan D; Kanisicak, Onur; Karch, Jason; Khalil, Hadi; Fu, Xing; Boyer, Justin G; Prasad, Vikram; Zheng, Yi; Molkentin, Jeffery D 2018. Gata4-Dependent Differentiation of c-Kit+ Derived Endothelial Cells Underlies Artefactual Cardiomyocyte Regeneration in the Heart. Circulation, , Mizukawa, Benjamin; O'Brien, Eric; Mulloy, James C; Zheng, Yi 2018. Cell Polarity and Division Symmetry Analyses in Transformed Blood Cells. Methods in molecular biology (Clifton, N.J.), 1821 , 257-266Sertorio, Mathieu; Perentesis, John P; Vatner, Ralph E; Mascia, Anthony E; Zheng, Yi; Wells, Susanne I 2018. Cancer Cell Metabolism: Implications for X-ray and Particle Radiation Therapy. International journal of particle therapy, 5 1, 40-48Wu, Lai Man Natalie; Deng, Yaqi; Wang, Jincheng; Zhao, Chuntao; Wang, Jiajia; Rao, Rohit; Xu, Lingli; Zhou, Wenhao; Choi, Kwangmin; Rizvi, Tilat A; Remke, Marc; Rubin, Joshua B; Johnson, Randy L; Carroll, Thomas J; Stemmer-Rachamimov, Anat O; Wu, Jianqiang; Zheng, Yi; Xin, Mei; Ratner, Nancy; Lu, Q Richard 2018. Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis. Cancer cell, 33 2, 292-308.e7Yang, Yingying; Dong, Panpan; Zhao, Jing; Zhou, Wei; Zhou, Yonghua; Xu, Yongliang; Mei, Congjin; Guo, Fukun; Zheng, Yi; Yang, Jun-Qi 2018. PKC?/? regulates Th17 differentiation and house dust mite-induced allergic airway inflammation. Biochimica et biophysica acta, 1864 3, 934-941Chen, Xiaoyi; Clark, Jason; Wunderlich, Mark; Fan, Cuiqing; Davis, Ashley; Chen, Song; Guan, Jun-Lin; Mulloy, James C; Kumar, Ashish; Zheng, Yi 2017. Autophagy is dispensable for Kmt2a/Mll-Mllt3/Af9 AML maintenance and anti-leukemic effect of chloroquine. Autophagy, 13 5, 955-966El Zowalaty, Ahmed E; Li, Rong; Zheng, Yi; Lydon, John P; DeMayo, Francesco J; Ye, Xiaoqin 2017. Deletion of RhoA in Progesterone Receptor-Expressing Cells Leads to Luteal Insufficiency and Infertility in Female Mice. Endocrinology, 158 7, 2168-2178Fang, Jing; Bolanos, Lyndsey C; Choi, Kwangmin; Liu, Xiaona; Christie, Susanne; Akunuru, Shailaja; Kumar, Rupali; Wang, Dehua; Chen, Xiaoting; Greis, Kenneth D; Stoilov, Peter; Filippi, Marie-Dominique; Maciejewski, Jaroslaw P; Garcia-Manero, Guillermo; Weirauch, Matthew T; Salomonis, Nathan; Geiger, Hartmut; Zheng, Yi; Starczynowski, Daniel T 2017. Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia. Nature immunology, 18 2, 236-245Guo, Fukun; Zheng, Yi 2017. Vav1: Friend and Foe of Cancer. Trends in cell biology, 27 12, 879-880Hato, Takashi; Winfree, Seth; Day, Richard; Sandoval, Ruben M; Molitoris, Bruce A; Yoder, Mervin C; Wiggins, Roger C; Zheng, Yi; Dunn, Kenneth W; Dagher, Pierre C 2017. Two-Photon Intravital Fluorescence Lifetime Imaging of the Kidney Reveals Cell-Type Specific Metabolic Signatures. Journal of the American Society of Nephrology : JASN, 28 8, 2420-2430Jiang, Xi; Hu, Chao; Ferchen, Kyle; Nie, Ji; Cui, Xiaolong; Chen, Chih-Hong; Cheng, Liting; Zuo, Zhixiang; Seibel, William; He, Chunjiang; Tang, Yixuan; Skibbe, Jennifer R; Wunderlich, Mark; Reinhold, William C; Dong, Lei; Shen, Chao; Arnovitz, Stephen; Ulrich, Bryan; Lu, Jiuwei; Weng, Hengyou; Su, Rui; Huang, Huilin; Wang, Yungui; Li, Chenying; Qin, Xi; Mulloy, James C; Zheng, Yi; Diao, Jiajie; Jin, Jie; Li, Chong; Liu, Paul P; He, Chuan; Chen, Yuan; Chen, Jianjun 2017. Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia. Nature communications, 8 1, 2099Kalim, Khalid W; Zhang, Shuangmin; Chen, Xiaoyi; Li, Yuan; Yang, Jun-Qi; Zheng, Yi; Guo, Fukun 2017. mTOR has a developmental stage-specific role in mitochondrial fitness independent of conventional mTORC1 and mTORC2 and the kinase activity. PloS one, 12 8, e0183266Li, Jingjing; Miao, Lianjie; Zhao, Chen; Shaikh Qureshi, Wasay Mohiuddin; Shieh, David; Guo, Hua; Lu, Yangyang; Hu, Saiyang; Huang, Alice; Zhang, Lu; Cai, Chen-Leng; Wan, Leo Q; Xin, Hongbo; Vincent, Peter; Singer, Harold A; Zheng, Yi; Cleaver, Ondine; Fan, Zhen-Chuan; Wu, Mingfu 2017. CDC42 is required for epicardial and pro-epicardial development by mediating FGF receptor trafficking to the plasma membrane. Development (Cambridge, England), 144 9, 1635-1647Liu, Ming; Zhang, Zheng; Sampson, Leesa; Zhou, Xuan; Nalapareddy, Kodandaramireddy; Feng, Yuxin; Akunuru, Shailaja; Melendez, Jaime; Davis, Ashley Kuenzi; Bi, Feng; Geiger, Hartmut; Xin, Mei; Zheng, Yi 2017. RHOA GTPase Controls YAP-Mediated EREG Signaling in Small Intestinal Stem Cell Maintenance. Stem cell reports, 9 6, 1961-1975Mizukawa, Benjamin; O'Brien, Eric; Moreira, Daniel C; Wunderlich, Mark; Hochstetler, Cindy L; Duan, Xin; Liu, Wei; Orr, Emily; Grimes, H Leighton; Mulloy, James C; Zheng, Yi 2017. The cell polarity determinant CDC42 controls division symmetry to block leukemia cell differentiation. Blood, 130 11, 1336-1346Nalapareddy, Kodandaramireddy; Nattamai, Kalpana J; Kumar, Rupali S; Karns, Rebekah; Wikenheiser-Brokamp, Kathryn A; Sampson, Leesa L; Mahe, Maxime M; Sundaram, Nambirajan; Yacyshyn, Mary-Beth; Yacyshyn, Bruce; Helmrath, Michael A; Zheng, Yi; Geiger, Hartmut 2017. Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells. Cell reports, 18 11, 2608-2621Qiu, Sugan; Fan, Xiaolin; Yang, Yingying; Dong, Panpan; Zhou, Wei; Xu, Yongliang; Zhou, Yonghua; Guo, Fukun; Zheng, Yi; Yang, Jun-Qi 2017. Schistosoma japonicum infection downregulates house dust mite-induced allergic airway inflammation in mice. PloS one, 12 6, e0179565Sakabe, Masahide; Fan, Jieqing; Odaka, Yoshinobu; Liu, Ning; Hassan, Aishlin; Duan, Xin; Stump, Paige; Byerly, Luke; Donaldson, Megan; Hao, Jiukuan; Fruttiger, Marcus; Lu, Qing Richard; Zheng, Yi; Lang, Richard A; Xin, Mei 2017. YAP/TAZ-CDC42 signaling regulates vascular tip cell migration. Proceedings of the National Academy of Sciences of the United States of America, 114 41, 10918-10923Sinagoga, Katie L; Stone, William J; Schiesser, Jacqueline V; Schweitzer, Jamie I; Sampson, Leesa; Zheng, Yi; Wells, James M 2017. Distinct roles for the mTOR pathway in postnatal morphogenesis, maturation and function of pancreatic islets. Development (Cambridge, England), 144 13, 2402-2414Zandvakili, I; Lin, Y; Morris, J C; Zheng, Y 2017. Rho GTPases: Anti- or pro-neoplastic targets? Oncogene, 36 23, 3213-3222Barry, David M; Koo, Yeon; Norden, Pieter R; Wylie, Lyndsay A; Xu, Ke; Wichaidit, Chonlarat; Azizoglu, D Berfin; Zheng, Yi; Cobb, Melanie H; Davis, George E; Cleaver, Ondine 2016. Rasip1-Mediated Rho GTPase Signaling Regulates Blood Vessel Tubulogenesis via Nonmuscle Myosin II. Circulation research, 119 7, 810-26Imai, Fumiyasu; Ladle, David R; Leslie, Jennifer R; Duan, Xin; Rizvi, Tilat A; Ciraolo, Georgianne M; Zheng, Yi; Yoshida, Yutaka 2016. Synapse Formation in Monosynaptic Sensory-Motor Connections Is Regulated by Presynaptic Rho GTPase Cdc42. The Journal of neuroscience : the official journal of the Society for Neuroscience, 36 21, 5724-35Nohata, Nijiro; Uchida, Yutaka; Stratman, Amber N; Adams, Ralf H; Zheng, Yi; Weinstein, Brant M; Mukouyama, Yoh-Suke; Gutkind, J Silvio 2016. Temporal-specific roles of Rac1 during vascular development and retinal angiogenesis. Developmental biology, 411 2, 183-194O'Hayre, M; Inoue, A; Kufareva, I; Wang, Z; Mikelis, C M; Drummond, R A; Avino, S; Finkel, K; Kalim, K W; DiPasquale, G; Guo, F; Aoki, J; Zheng, Y; Lionakis, M S; Molinolo, A A; Gutkind, J S 2016. Inactivating mutations in GNA13 and RHOA in Burkitt's lymphoma and diffuse large B-cell lymphoma: a tumor suppressor function for the G?13/RhoA axis in B cells. Oncogene, 35 29, 3771-80Palazzo, A; Bluteau, O; Messaoudi, K; Marangoni, F; Chang, Y; Souquere, S; Pierron, G; Lapierre, V; Zheng, Y; Vainchenker, W; Raslova, H; Debili, N 2016. The cell division control protein 42-Src family kinase-neural Wiskott-Aldrich syndrome protein pathway regulates human proplatelet formation. Journal of thrombosis and haemostasis : JTH, 14 12, 2524-2535Sampson, Leesa L; Davis, Ashley K; Grogg, Matthew W; Zheng, Yi 2016. mTOR disruption causes intestinal epithelial cell defects and intestinal atrophy postinjury in mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 30 3, 1263-75Yang, Jun-Qi; Kalim, Khalid W; Li, Yuan; Zhang, Shuangmin; Hinge, Ashwini; Filippi, Marie-Dominique; Zheng, Yi; Guo, Fukun 2016. RhoA orchestrates glycolysis for TH2 cell differentiation and allergic airway inflammation. The Journal of allergy and clinical immunology, 137 1, 231-245.e4Barry, David M; Xu, Ke; Meadows, Stryder M; Zheng, Yi; Norden, Pieter R; Davis, George E; Cleaver, Ondine 2015. Cdc42 is required for cytoskeletal support of endothelial cell adhesion during blood vessel formation in mice. Development (Cambridge, England), 142 17, 3058-70Chang, Kyung Hee; Nayak, Ramesh C; Roy, Swarnava; Perumbeti, Ajay; Wellendorf, Ashley M; Bezold, Katie Y; Pirman, Megan; Hill, Sarah E; Starnes, Joseph; Loberg, Anastacia; Zhou, Xuan; Inagami, Tadashi; Zheng, Yi; Malik, Punam; Cancelas, Jose A 2015. Vasculopathy-associated hyperangiotensinemia mobilizes haematopoietic stem cells/progenitors through endothelial AT?R and cytoskeletal dysregulation. Nature communications, 6 , 5914Evelyn, Chris R; Biesiada, Jacek; Duan, Xin; Tang, Hong; Shang, Xun; Papoian, Ruben; Seibel, William L; Nelson, Sandra; Meller, Jaroslaw; Zheng, Yi 2015. Combined rational design and a high throughput screening platform for identifying chemical inhibitors of a Ras-activating enzyme. The Journal of biological chemistry, 290 20, 12879-98Kesarwani, Meenu; Huber, Erika; Kincaid, Zachary; Evelyn, Chris R; Biesiada, Jacek; Rance, Mark; Thapa, Mahendra B; Shah, Neil P; Meller, Jarek; Zheng, Yi; Azam, Mohammad 2015. Targeting substrate-site in Jak2 kinase prevents emergence of genetic resistance. Scientific reports, 5 , 14538Konstantinidis, Diamantis G; Giger, Katie M; Risinger, Mary; Pushkaran, Suvarnamala; Zhou, Ping; Dexheimer, Phillip; Yerneni, Satwica; Andreassen, Paul; Klingmüller, Ursula; Palis, James; Zheng, Yi; Kalfa, Theodosia A 2015. Cytokinesis failure in RhoA-deficient mouse erythroblasts involves actomyosin and midbody dysregulation and triggers p53 activation. Blood, 126 12, 1473-82Li, Juan; Zhang, Lei; Chen, Zhenzhong; Xie, Minjuan; Huang, Lu; Xue, Jinhua; Liu, Yutong; Liu, Nuyun; Guo, Fukun; Zheng, Yi; Kong, Jiming; Zhang, Lin; Zhang, Lu 2015. Cocaine activates Rac1 to control structural and behavioral plasticity in caudate putamen. Neurobiology of disease, 75 , 159-76Lin, Yuan; Zheng, Yi 2015. Approaches of targeting Rho GTPases in cancer drug discovery. Expert opinion on drug discovery, 10 9, 991-1010Mikelis, Constantinos M; Simaan, May; Ando, Koji; Fukuhara, Shigetomo; Sakurai, Atsuko; Amornphimoltham, Panomwat; Masedunskas, Andrius; Weigert, Roberto; Chavakis, Triantafyllos; Adams, Ralf H; Offermanns, Stefan; Mochizuki, Naoki; Zheng, Yi; Gutkind, J Silvio 2015. RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock. Nature communications, 6 , 6725Zandvakili, Inuk; Davis, Ashley Kuenzi; Hu, Guodong; Zheng, Yi 2015. Loss of RhoA Exacerbates, Rather Than Dampens, Oncogenic K-Ras Induced Lung Adenoma Formation in Mice. PloS one, 10 6, e0127923Delaney, Michael Keegan; Liu, Junling; Kim, Kyungho; Shen, Bo; Stojanovic-Terpo, Aleksandra; Zheng, Yi; Cho, Jaehyung; Du, Xiaoping 2014. Agonist-induced platelet procoagulant activity requires shear and a Rac1-dependent signaling mechanism. Blood, 124 12, 1957-67Evelyn, Chris R; Duan, Xin; Biesiada, Jacek; Seibel, William L; Meller, Jaroslaw; Zheng, Yi 2014. Rational design of small molecule inhibitors targeting the Ras GEF, SOS1. Chemistry & biology, 21 12, 1618-28Fabbiano, Salvatore; Menacho-Márquez, Mauricio; Sevilla, María A; Albarrán-Juárez, Julián; Zheng, Yi; Offermanns, Stefan; Montero, María J; Bustelo, Xosé R 2014. Genetic dissection of the vav2-rac1 signaling axis in vascular smooth muscle cells. Molecular and cellular biology, 34 24, 4404-19Geiger, Hartmut; Zheng, Yi 2014. Regulation of hematopoietic stem cell aging by the small RhoGTPase Cdc42. Experimental cell research, 329 2, 214-9Guo, F; Li, J; Zhang, S; Du, W; Amarachintha, S; Sipple, J; Phelan, J; Grimes, H L; Zheng, Y; Pang, Q 2014. mTOR kinase inhibitor sensitizes T-cell lymphoblastic leukemia for chemotherapy-induced DNA damage via suppressing FANCD2 expression. Leukemia, 28 1, 203-6Kalfa, Theodosia A; Zheng, Yi 2014. Rho GTPases in erythroid maturation. Current opinion in hematology, 21 3, 165-71Konstantinidis, Diamantis G; Pushkaran, Suvarnamala; Giger, Katie; Manganaris, Stefanos; Zheng, Yi; Kalfa, Theodosia A 2014. Identification of a murine erythroblast subpopulation enriched in enucleating events by multi-spectral imaging flow cytometry. Journal of visualized experiments : JoVE, 88, Sakamori, Ryotaro; Yu, Shiyan; Zhang, Xiao; Hoffman, Andrew; Sun, Jiaxin; Das, Soumyashree; Vedula, Pavan; Li, Guangxun; Fu, Jiang; Walker, Francesca; Yang, Chung S; Yi, Zheng; Hsu, Wei; Yu, Da-Hai; Shen, Lanlan; Rodriguez, Alexis J; Taketo, Makoto M; Bonder, Edward M; Verzi, Michael P; Gao, Nan 2014. CDC42 inhibition suppresses progression of incipient intestinal tumors. Cancer research, 74 19, 5480-92Zhang, Shuangmin; Konstantinidis, Diamantis G; Yang, Jun-Qi; Mizukawa, Benjamin; Kalim, Khalid; Lang, Richard A; Kalfa, Theodosia A; Zheng, Yi; Guo, Fukun 2014. Gene targeting RhoA reveals its essential role in coordinating mitochondrial function and thymocyte development. Journal of immunology (Baltimore, Md. : 1950), 193 12, 5973-82Zheng, Yi; Geiger, Hartmut 2014. HSPCs get their motors running for asymmetric fate choice. Cell stem cell, 14 1, 1-2Zhu, Yajie; Zhou, Jitao; Xia, Hongwei; Chen, Xiangzheng; Qiu, Meng; Huang, Juan; Liu, Surui; Tang, Qiulin; Lang, Nan; Liu, Zhen; Liu, Ming; Zheng, Yi; Bi, Feng 2014. The Rho GTPase RhoE is a p53-regulated candidate tumor suppressor in cancer cells. International journal of oncology, 44 3, 896-904Guo, F; Li, J; Du, W; Zhang, S; O'Connor, M; Thomas, G; Kozma, S; Zingarelli, B; Pang, Q; Zheng, Y 2013. mTOR regulates DNA damage response through NF-?B-mediated FANCD2 pathway in hematopoietic cells. Leukemia, 27 10, 2040-2046Guo, Li; Moon, Chandra; Zheng, Yi; Ratner, Nancy 2013. Cdc42 regulates Schwann cell radial sorting and myelin sheath folding through NF2/merlin-dependent and independent signaling. Glia, 61 11, 1906-21Katayama, Kei-ichi; Imai, Fumiyasu; Campbell, Kenneth; Lang, Richard A; Zheng, Yi; Yoshida, Yutaka 2013. RhoA and Cdc42 are required in pre-migratory progenitors of the medial ganglionic eminence ventricular zone for proper cortical interneuron migration. Development (Cambridge, England), 140 15, 3139-45Melendez, Jaime; Liu, Ming; Sampson, Leesa; Akunuru, Shailaja; Han, Xiaonan; Vallance, Jefferson; Witte, David; Shroyer, Noah; Zheng, Yi 2013. Cdc42 coordinates proliferation, polarity, migration, and differentiation of small intestinal epithelial cells in mice. Gastroenterology, 145 4, 808-19Shang, Xun; Marchioni, Fillipo; Evelyn, Chris R; Sipes, Nisha; Zhou, Xuan; Seibel, William; Wortman, Matthew; Zheng, Yi 2013. Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors. Proceedings of the National Academy of Sciences of the United States of America, 110 8, 3155-60Zhou, Xuan; Florian, Maria Carolina; Arumugam, Paritha; Chen, Xiaoyi; Cancelas, Jose A; Lang, Richard; Malik, Punam; Geiger, Hartmut; Zheng, Yi 2013. RhoA GTPase controls cytokinesis and programmed necrosis of hematopoietic progenitors. The Journal of experimental medicine, 210 11, 2371-85Zhou, Xuan; Zheng, Yi 2013. Cell type-specific signaling function of RhoA GTPase: lessons from mouse gene targeting. The Journal of biological chemistry, 288 51, 36179-88Akunuru, S; James Zhai, Q; Zheng, Y 2012. Non-small cell lung cancer stem/progenitor cells are enriched in multiple distinct phenotypic subpopulations and exhibit plasticity. Cell death & disease, 3 , e352Bosco, Emily E; Kumar, Sachin; Marchioni, Filippo; Biesiada, Jacek; Kordos, Miroslaw; Szczur, Kathleen; Meller, Jarek; Seibel, William; Mizrahi, Ariel; Pick, Edgar; Filippi, Marie-Dominique; Zheng, Yi 2012. Rational design of small molecule inhibitors targeting the Rac GTPase-p67(phox) signaling axis in inflammation. Chemistry & biology, 19 2, 228-42Chang, Kyung Hee; Sanchez-Aguilera, Abel; Shen, Shuhong; Sengupta, Amitava; Madhu, Malav N; Ficker, Ashley M; Dunn, Susan K; Kuenzi, Ashley M; Arnett, Jorden L; Santho, Rebecca A; Agirre, Xabier; Perentesis, John P; Deininger, Michael W; Zheng, Yi; Bustelo, Xose R; Williams, David A; Cancelas, Jose A 2012. Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival. Blood, 120 4, 800-11Guo, Li; Moon, Chandra; Niehaus, Karen; Zheng, Yi; Ratner, Nancy 2012. Rac1 controls Schwann cell myelination through cAMP and NF2/merlin. The Journal of neuroscience : the official journal of the Society for Neuroscience, 32 48, 17251-61Katayama, Kei-ichi; Leslie, Jennifer R; Lang, Richard A; Zheng, Yi; Yoshida, Yutaka 2012. Left-right locomotor circuitry depends on RhoA-driven organization of the neuroepithelium in the developing spinal cord. The Journal of neuroscience : the official journal of the Society for Neuroscience, 32 30, 10396-407Konstantinidis, Diamantis G; Pushkaran, Suvarnamala; Johnson, James F; Cancelas, Jose A; Manganaris, Stefanos; Harris, Chad E; Williams, David A; Zheng, Yi; Kalfa, Theodosia A 2012. Signaling and cytoskeletal requirements in erythroblast enucleation. Blood, 119 25, 6118-27Kumar, Sachin; Xu, Juying; Perkins, Charles; Guo, Fukun; Snapper, Scott; Finkelman, Fred D; Zheng, Yi; Filippi, Marie-Dominique 2012. Cdc42 regulates neutrophil migration via crosstalk between WASp, CD11b, and microtubules. Blood, 120 17, 3563-74Leslie, Jennifer R; Imai, Fumiyasu; Zhou, Xuan; Lang, Richard A; Zheng, Yi; Yoshida, Yutaka 2012. RhoA is dispensable for axon guidance of sensory neurons in the mouse dorsal root ganglia. Frontiers in molecular neuroscience, 5 , 67Liu, Ming; Bi, Feng; Zhou, Xuan; Zheng, Yi 2012. Rho GTPase regulation by miRNAs and covalent modifications. Trends in cell biology, 22 7, 365-73Shang, Xun; Marchioni, Fillipo; Sipes, Nisha; Evelyn, Chris R; Jerabek-Willemsen, Moran; Duhr, Stefan; Seibel, William; Wortman, Matthew; Zheng, Yi 2012. Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases. Chemistry & biology, 19 6, 699-710Shang, Xun; Zheng, Yi 2012. Rational design of Rho GTPase-targeting inhibitors. Methods in molecular biology (Clifton, N.J.), 928 , 29-38Tan, Zongqing; Wortman, Matthew; Dillehay, Kelsey L; Seibel, William L; Evelyn, Chris R; Smith, Shanna J; Malkas, Linda H; Zheng, Yi; Lu, Shan; Dong, Zhongyun 2012. Small-molecule targeting of proliferating cell nuclear antigen chromatin association inhibits tumor cell growth. Molecular pharmacology, 81 6, 811-9Akunuru, Shailaja; Palumbo, Joseph; Zhai, Qihui James; Zheng, Yi 2011. Rac1 targeting suppresses human non-small cell lung adenocarcinoma cancer stem cell activity. PloS one, 6 2, e16951Chauhan, Bharesh K; Lou, Ming; Zheng, Yi; Lang, Richard A 2011. Balanced Rac1 and RhoA activities regulate cell shape and drive invagination morphogenesis in epithelia. Proceedings of the National Academy of Sciences of the United States of America, 108 45, 18289-94Geh, Esmond; Meng, Qinghang; Mongan, Maureen; Wang, Jingcai; Takatori, Atsushi; Zheng, Yi; Puga, Alvaro; Lang, Richard A; Xia, Ying 2011. Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) integrates developmental signals for eyelid closure. Proceedings of the National Academy of Sciences of the United States of America, 108 42, 17349-54Guo, Fukun; Zhang, Shuangmin; Tripathi, Pulak; Mattner, Jochen; Phelan, James; Sproles, Alyssa; Mo, Jun; Wills-Karp, Marsha; Grimes, H Leighton; Hildeman, David; Zheng, Yi 2011. Distinct roles of Cdc42 in thymopoiesis and effector and memory T cell differentiation. PloS one, 6 3, e18002Katayama, Kei-ichi; Melendez, Jaime; Baumann, Jessica M; Leslie, Jennifer R; Chauhan, Bharesh K; Nemkul, Niza; Lang, Richard A; Kuan, Chia-Yi; Zheng, Yi; Yoshida, Yutaka 2011. Loss of RhoA in neural progenitor cells causes the disruption of adherens junctions and hyperproliferation. Proceedings of the National Academy of Sciences of the United States of America, 108 18, 7607-12Liu, Wei; Feng, Yuxin; Shang, Xun; Zheng, Yi 2011. Rho GTPases in hematopoietic stem/progenitor cell migration. Methods in molecular biology (Clifton, N.J.), 750 , 307-19Melendez, Jaime; Grogg, Matthew; Zheng, Yi 2011. Signaling role of Cdc42 in regulating mammalian physiology. The Journal of biological chemistry, 286 4, 2375-81Melendez, Jaime; Stengel, Kristy; Zhou, Xuan; Chauhan, Bharesh K; Debidda, Marcella; Andreassen, Paul; Lang, Richard A; Zheng, Yi 2011. RhoA GTPase is dispensable for actomyosin regulation but is essential for mitosis in primary mouse embryonic fibroblasts. The Journal of biological chemistry, 286 17, 15132-7Mizukawa, Benjamin; Wei, Junping; Shrestha, Mahesh; Wunderlich, Mark; Chou, Fu-Sheng; Griesinger, Andrea; Harris, Chad E; Kumar, Ashish R; Zheng, Yi; Williams, David A; Mulloy, James C 2011. Inhibition of Rac GTPase signaling and downstream prosurvival Bcl-2 proteins as combination targeted therapy in MLL-AF9 leukemia. Blood, 118 19, 5235-45Morrison, Monique A; Morreale, Richard J; Akunuru, Shailaja; Kofron, Matthew; Zheng, Yi; Wells, Susanne I 2011. Targeting the human papillomavirus E6 and E7 oncogenes through expression of the bovine papillomavirus type 1 E2 protein stimulates cellular motility. Journal of virology, 85 20, 10487-98Plageman, Timothy F; Chauhan, Bharesh K; Yang, Christine; Jaudon, Fanny; Shang, Xun; Zheng, Yi; Lou, Ming; Debant, Anne; Hildebrand, Jeffrey D; Lang, Richard A 2011. A Trio-RhoA-Shroom3 pathway is required for apical constriction and epithelial invagination. Development (Cambridge, England), 138 23, 5177-88Shang, Xun; Cancelas, Jose A; Li, Lina; Guo, Fukun; Liu, Wei; Johnson, James F; Ficker, Ashley; Daria, Deidre; Geiger, Hartmut; Ratner, Nancy; Zheng, Yi 2011. R-Ras and Rac GTPase cross-talk regulates hematopoietic progenitor cell migration, homing, and mobilization. The Journal of biological chemistry, 286 27, 24068-78Sipes, Nisha S; Feng, Yuxin; Guo, Fukun; Lee, Hyung-Ok; Chou, Fu-Sheng; Cheng, Jonathan; Mulloy, James; Zheng, Yi 2011. Cdc42 regulates extracellular matrix remodeling in three dimensions. The Journal of biological chemistry, 286 42, 36469-77Stengel, Kristy; Zheng, Yi 2011. Cdc42 in oncogenic transformation, invasion, and tumorigenesis. Cellular signalling, 23 9, 1415-23Wang, Xiaofang; Zhang, Fan; Chen, Fanping; Liu, Dou; Zheng, Yi; Zhang, Yongliang; Dong, Chen; Su, Bing 2011. MEKK3 regulates IFN-gamma production in T cells through the Rac1/2-dependent MAPK cascades. Journal of immunology (Baltimore, Md. : 1950), 186 10, 5791-800Bosco, E E; Nakai, Y; Hennigan, R F; Ratner, N; Zheng, Y 2010. NF2-deficient cells depend on the Rac1-canonical Wnt signaling pathway to promote the loss of contact inhibition of proliferation. Oncogene, 29 17, 2540-9Bosco, Emily E; Ni, Wenjun; Wang, Lei; Guo, Fukun; Johnson, James F; Zheng, Yi 2010. Rac1 targeting suppresses p53 deficiency-mediated lymphomagenesis. Blood, 115 16, 3320-8George, Alex; Pushkaran, Suvarnamala; Li, Lina; An, Xiuli; Zheng, Yi; Mohandas, Narla; Joiner, Clinton H; Kalfa, Theodosia A 2010. Altered phosphorylation of cytoskeleton proteins in sickle red blood cells: the role of protein kinase C, Rac GTPases, and reactive oxygen species. Blood cells, molecules & diseases, 45 1, 41-5Guo, Fukun; Hildeman, David; Tripathi, Pulak; Velu, Chinavenmeni S; Grimes, H Leighton; Zheng, Yi 2010. Coordination of IL-7 receptor and T-cell receptor signaling by cell-division cycle 42 in T-cell homeostasis. Proceedings of the National Academy of Sciences of the United States of America, 107 43, 18505-10Kalfa, Theodosia A; Pushkaran, Suvarnamala; Zhang, Xiaoling; Johnson, James F; Pan, Dao; Daria, Deidre; Geiger, Hartmut; Cancelas, Jose A; Williams, David A; Zheng, Yi 2010. Rac1 and Rac2 GTPases are necessary for early erythropoietic expansion in the bone marrow but not in the spleen. Haematologica, 95 1, 27-35Mulloy, James C; Cancelas, Jose A; Filippi, Marie-Dominique; Kalfa, Theodosia A; Guo, Fukun; Zheng, Yi 2010. Rho GTPases in hematopoiesis and hemopathies. Blood, 115 5, 936-47Mulloy, James C; Cancelas, Jose A; Filippi, Marie-Dominique; Kalfa, Theodosia A; Guo, Fukun; Zheng, Yi 2010. Rho GTPases in hematopoiesis and hemopathies. Blood, 115 5, 936-47Ryan, Marnie A; Nattamai, Kalpana J; Xing, Ellen; Schleimer, David; Daria, Deidre; Sengupta, Amitava; Köhler, Anja; Liu, Wei; Gunzer, Matthias; Jansen, Michael; Ratner, Nancy; Le Cras, Timothy D; Waterstrat, Amanda; Van Zant, Gary; Cancelas, Jose A; Zheng, Yi; Geiger, Hartmut 2010. Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilization. Nature medicine, 16 10, 1141-6Bosco, E E; Mulloy, J C; Zheng, Y 2009. Rac1 GTPase: a "Rac" of all trades. Cellular and molecular life sciences : CMLS, 66 3, 370-4Chauhan, Bharesh K; Disanza, Andrea; Choi, Sue-Yeon; Faber, Sonya C; Lou, Ming; Beggs, Hilary E; Scita, Giorgio; Zheng, Yi; Lang, Richard A 2009. Cdc42- and IRSp53-dependent contractile filopodia tether presumptive lens and retina to coordinate epithelial invagination. Development (Cambridge, England), 136 21, 3657-67Chen, Lei; Melendez, Jaime; Campbell, Kenneth; Kuan, Chia-Yi; Zheng, Yi 2009. Rac1 deficiency in the forebrain results in neural progenitor reduction and microcephaly. Developmental biology, 325 1, 162-70Guo, Fukun; Velu, Chinavenmeni S; Grimes, H Leighton; Zheng, Yi 2009. Rho GTPase Cdc42 is essential for B-lymphocyte development and activation. Blood, 114 14, 2909-16Maillet, Marjorie; Lynch, Jeffrey M; Sanna, Bastiano; York, Allen J; Zheng, Yi; Molkentin, Jeffery D 2009. Cdc42 is an antihypertrophic molecular switch in the mouse heart. The Journal of clinical investigation, 119 10, 3079-88Marchioni, Filippo; Zheng, Yi 2009. Targeting rho GTPases by peptidic structures. Current pharmaceutical design, 15 21, 2481-7Milsom, Michael D; Lee, Andrew W; Zheng, Yi; Cancelas, Jose A 2009. Fanca-/- hematopoietic stem cells demonstrate a mobilization defect which can be overcome by administration of the Rac inhibitor NSC23766. Haematologica, 94 7, 1011-5Szczur, Kathleen; Zheng, Yi; Filippi, Marie-Dominique 2009. The small Rho GTPase Cdc42 regulates neutrophil polarity via CD11b integrin signaling. Blood, 114 20, 4527-37Xu, Haiming; Eleswarapu, Satyam; Geiger, Hartmut; Szczur, Kathleen; Daria, Deidre; Zheng, Yi; Settleman, Jeffrey; Srour, Edward F; Williams, David A; Filippi, Marie-Dominique 2009. Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential. Blood, 114 17, 3557-66Mulloy, James C; Wunderlich, Mark; Zheng, Yi; Wei, Junping 2008. Transforming human blood stem and progenitor cells: a new way forward in leukemia modeling. Cell cycle (Georgetown, Tex.), 7 21, 3314-9Thomas, E K; Cancelas, J A; Zheng, Y; Williams, D A 2008. Rac GTPases as key regulators of p210-BCR-ABL-dependent leukemogenesis. Leukemia, 22 5, 898-904Wei, Junping; Wunderlich, Mark; Fox, Catherine; Alvarez, Sara; Cigudosa, Juan C; Wilhelm, Jamie S; Zheng, Yi; Cancelas, Jose A; Gu, Yi; Jansen, Michael; Dimartino, Jorge F; Mulloy, James C 2008. Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia. Cancer cell, 13 6, 483-95Williams, David A; Zheng, Yi; Cancelas, Jose A 2008. Rho GTPases and regulation of hematopoietic stem cell localization. Methods in enzymology, 439 , 365-93Zhang, Xiaoling; Shang, Xun; Guo, Fukun; Murphy, Kim; Kirby, Michelle; Kelly, Patrick; Reeves, Lilith; Smith, Franklin O; Williams, David A; Zheng, Yi; Pang, Qishen 2008. Defective homing is associated with altered Cdc42 activity in cells from patients with Fanconi anemia group A. Blood, 112 5, 1683-6Akbar, H; Kim, J; Funk, K; Cancelas, J A; Shang, X; Chen, L; Johnson, J F; Williams, D A; Zheng, Y 2007. Genetic and pharmacologic evidence that Rac1 GTPase is involved in regulation of platelet secretion and aggregation. Journal of thrombosis and haemostasis : JTH, 5 8, 1747-55Chen, Lei; Liao, Guanghong; Waclaw, Ronald R; Burns, Kevin A; Linquist, Diana; Campbell, Kenneth; Zheng, Yi; Kuan, Chia-Yi 2007. Rac1 controls the formation of midline commissures and the competency of tangential migration in ventral telencephalic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience, 27 14, 3884-93Guo, Dagang; Tan, Ying-cai; Wang, Dawei; Madhusoodanan, K S; Zheng, Yi; Maack, Thomas; Zhang, J Jillian; Huang, Xin-Yun 2007. A Rac-cGMP signaling pathway. Cell, 128 2, 341-55Shang, Xun; Moon, Sun Young; Zheng, Yi 2007. p200 RhoGAP promotes cell proliferation by mediating cross-talk between Ras and Rho signaling pathways. The Journal of biological chemistry, 282 12, 8801-11Thomas, Emily K; Cancelas, Jose A; Chae, Hee-Don; Cox, Adrienne D; Keller, Patricia J; Perrotti, Danilo; Neviani, Paolo; Druker, Brian J; Setchell, Kenneth D R; Zheng, Yi; Harris, Chad E; Williams, David A 2007. Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease. Cancer cell, 12 5, 467-78Thomas, Emily K; Cancelas, Jose A; Chae, Hee-Don; Cox, Adrienne D; Keller, Patricia J; Perrotti, Danilo; Neviani, Paolo; Druker, Brian J; Setchell, Kenneth D R; Zheng, Yi; Harris, Chad E; Williams, David A 2007. Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease. Cancer cell, 12 5, 467-78Wang, Lei; Yang, Linda; Debidda, Marcella; Witte, David; Zheng, Yi 2007. Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes. Proceedings of the National Academy of Sciences of the United States of America, 104 4, 1248-53Wang, Lei; Zheng, Yi 2007. Cell type-specific functions of Rho GTPases revealed by gene targeting in mice. Trends in cell biology, 17 2, 58-64Yang, Linda; Wang, Lei; Geiger, Hartmut; Cancelas, Jose A; Mo, Jun; Zheng, Yi 2007. Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrow. Proceedings of the National Academy of Sciences of the United States of America, 104 12, 5091-6Yang, Linda; Wang, Lei; Kalfa, Theodosia A; Cancelas, Jose A; Shang, Xun; Pushkaran, Suvarnamala; Mo, Jun; Williams, David A; Zheng, Yi 2007. Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis. Blood, 110 12, 3853-61Yang, Linda; Zheng, Yi 2007. Cdc42: a signal coordinator in hematopoietic stem cell maintenance. Cell cycle (Georgetown, Tex.), 6 12, 1445-50Akbar, Huzoor; Cancelas, Jose; Williams, David A; Zheng, Jie; Zheng, Yi 2006. Rational design and applications of a Rac GTPase-specific small molecule inhibitor. Methods in enzymology, 406 , 554-65Chen, Lei; Liao, Guanghong; Yang, Linda; Campbell, Kenneth; Nakafuku, Masato; Kuan, Chia-Yi; Zheng, Yi 2006. Cdc42 deficiency causes Sonic hedgehog-independent holoprosencephaly. Proceedings of the National Academy of Sciences of the United States of America, 103 44, 16520-5Debidda, Marcella; Williams, David A; Zheng, Yi 2006. Rac1 GTPase regulates cell genomic stability and senescence. The Journal of biological chemistry, 281 50, 38519-28Ghiaur, Gabriel; Lee, Andrew; Bailey, Jeff; Cancelas, Jose A; Zheng, Yi; Williams, David A 2006. Inhibition of RhoA GTPase activity enhances hematopoietic stem and progenitor cell proliferation and engraftment. Blood, 108 6, 2087-94Gu, Y; Siefring, J E; Wang, L; Chae, H-D; Bailey, J R; Zheng, Y 2006. Oncogenic Vav1 induces Rac-dependent apoptosis via inhibition of Bcl-2 family proteins and collaborates with p53 deficiency to promote hematopoietic progenitor cell proliferation. Oncogene, 25 28, 3963-72Guo, Fukun; Debidda, Marcella; Yang, Linda; Williams, David A; Zheng, Yi 2006. Genetic deletion of Rac1 GTPase reveals its critical role in actin stress fiber formation and focal adhesion complex assembly. The Journal of biological chemistry, 281 27, 18652-9Kalfa, Theodosia A; Pushkaran, Suvarnamala; Mohandas, Narla; Hartwig, John H; Fowler, Velia M; Johnson, James F; Joiner, Clinton H; Williams, David A; Zheng, Yi 2006. Rac GTPases regulate the morphology and deformability of the erythrocyte cytoskeleton. Blood, 108 12, 3637-45Nakai, Yoko; Zheng, Yi; MacCollin, Mia; Ratner, Nancy 2006. Temporal control of Rac in Schwann cell-axon interaction is disrupted in NF2-mutant schwannoma cells. The Journal of neuroscience : the official journal of the Society for Neuroscience, 26 13, 3390-5Nakai, Yoko; Zheng, Yi; MacCollin, Mia; Ratner, Nancy 2006. Temporal control of Rac in Schwann cell-axon interaction is disrupted in NF2-mutant schwannoma cells. The Journal of neuroscience : the official journal of the Society for Neuroscience, 26 13, 3390-5Nassar, Nicolas; Cancelas, Jose; Zheng, Jie; Williams, David A; Zheng, Yi 2006. Structure-function based design of small molecule inhibitors targeting Rho family GTPases. Current topics in medicinal chemistry, 6 11, 1109-16Szczur, Kathleen; Xu, Haiming; Atkinson, Simon; Zheng, Yi; Filippi, Marie-Dominique 2006. Rho GTPase CDC42 regulates directionality and random movement via distinct MAPK pathways in neutrophils. Blood, 108 13, 4205-13Wang, Lei; Yang, Linda; Filippi, Marie-Dominique; Williams, David A; Zheng, Yi 2006. Genetic deletion of Cdc42GAP reveals a role of Cdc42 in erythropoiesis and hematopoietic stem/progenitor cell survival, adhesion, and engraftment. Blood, 107 1, 98-105Xing, Zhenlan; Ryan, Marnie A; Daria, Deidre; Nattamai, Kalpana J; Van Zant, Gary; Wang, Lei; Zheng, Yi; Geiger, Hartmut 2006. Increased hematopoietic stem cell mobilization in aged mice. Blood, 108 7, 2190-7Yang, Linda; Wang, Lei; Zheng, Yi 2006. Gene targeting of Cdc42 and Cdc42GAP affirms the critical involvement of Cdc42 in filopodia induction, directed migration, and proliferation in primary mouse embryonic fibroblasts. Molecular biology of the cell, 17 11, 4675-85Cancelas, Jose A; Lee, Andrew W; Prabhakar, Rethinasamy; Stringer, Keith F; Zheng, Yi; Williams, David A 2005. Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization. Nature medicine, 11 8, 886-91Carstanjen, Dirk; Yamauchi, Akira; Koornneef, Annemart; Zang, Heesuk; Filippi, Marie-Dominique; Harris, Chad; Towe, Jason; Atkinson, Simon; Zheng, Yi; Dinauer, Mary C; Williams, David A 2005. Rac2 regulates neutrophil chemotaxis, superoxide production, and myeloid colony formation through multiple distinct effector pathways. Journal of immunology (Baltimore, Md. : 1950), 174 8, 4613-20Debidda, Marcella; Wang, Lei; Zang, Heesuk; Poli, Valeria; Zheng, Yi 2005. A role of STAT3 in Rho GTPase-regulated cell migration and proliferation. The Journal of biological chemistry, 280 17, 17275-85Gu, Yi; Zheng, Yi; Williams, David A 2005. RhoH GTPase: a key regulator of hematopoietic cell proliferation and apoptosis? Cell cycle (Georgetown, Tex.), 4 2, 201-2Wang, Lei; Yang, Linda; Burns, Kevin; Kuan, Chia-Yi; Zheng, Yi 2005. Cdc42GAP regulates c-Jun N-terminal kinase (JNK)-mediated apoptosis and cell number during mammalian perinatal growth. Proceedings of the National Academy of Sciences of the United States of America, 102 38, 13484-9Zhang, Lin; Deng, Maoxian; Parthasarathy, Ranjani; Wang, Lei; Mongan, Maureen; Molkentin, Jeffery D; Zheng, Yi; Xia, Ying 2005. MEKK1 transduces activin signals in keratinocytes to induce actin stress fiber formation and migration. Molecular and cellular biology, 25 1, 60-5Cook-Mills, Joan M; Johnson, Jacob D; Deem, Tracy L; Ochi, Atsuo; Wang, Lei; Zheng, Yi 2004. Calcium mobilization and Rac1 activation are required for VCAM-1 (vascular cell adhesion molecule-1) stimulation of NADPH oxidase activity. The Biochemical journal, 378 Pt 2, 539-47Debreceni, Balazs; Gao, Yuan; Guo, Fukun; Zhu, Kejin; Jia, Baoqing; Zheng, Yi 2004. Mechanisms of guanine nucleotide exchange and Rac-mediated signaling revealed by a dominant negative trio mutant. The Journal of biological chemistry, 279 5, 3777-86Filippi, Marie-Dominique; Harris, Chad E; Meller, Jarek; Gu, Yi; Zheng, Yi; Williams, David A 2004. Localization of Rac2 via the C terminus and aspartic acid 150 specifies superoxide generation, actin polarity and chemotaxis in neutrophils. Nature immunology, 5 7, 744-51Gao, Yuan; Dickerson, J Bradley; Guo, Fukun; Zheng, Jie; Zheng, Yi 2004. Rational design and characterization of a Rac GTPase-specific small molecule inhibitor. Proceedings of the National Academy of Sciences of the United States of America, 101 20, 7618-23Guo, Fukun; Zheng, Yi 2004. Rho family GTPases cooperate with p53 deletion to promote primary mouse embryonic fibroblast cell invasion. Oncogene, 23 33, 5577-85Guo, Fukun; Zheng, Yi 2004. Involvement of Rho family GTPases in p19Arf- and p53-mediated proliferation of primary mouse embryonic fibroblasts. Molecular and cellular biology, 24 3, 1426-38Wang, Lei; Zhu, Kejin; Zheng, Yi 2004. Oncogenic Dbl, Cdc42, and p21-activated kinase form a ternary signaling intermediate through the minimum interactive domains. Biochemistry, 43 46, 14584-93Guo, Fukun; Gao, Yuan; Wang, Lei; Zheng, Yi 2003. p19Arf-p53 tumor suppressor pathway regulates cell motility by suppression of phosphoinositide 3-kinase and Rac1 GTPase activities. The Journal of biological chemistry, 278 16, 14414-9Moon, Sun Young; Zang, Heesuk; Zheng, Yi 2003. Characterization of a brain-specific Rho GTPase-activating protein, p200RhoGAP. The Journal of biological chemistry, 278 6, 4151-9Moon, Sun Young; Zheng, Yi 2003. Rho GTPase-activating proteins in cell regulation. Trends in cell biology, 13 1, 13-22Wang, Lei; Yang, Linda; Luo, Yongneng; Zheng, Yi 2003. A novel strategy for specifically down-regulating individual Rho GTPase activity in tumor cells. The Journal of biological chemistry, 278 45, 44617-25Zheng, Yi; Quilliam, Lawrence A 2003. Activation of the Ras superfamily of small GTPases. Workshop on exchange factors. EMBO reports, 4 5, 463-8Akbar, Huzoor; Duan, Xin; Saleem, Saima; Davis, Ashley K; Zheng, Yi . RhoA and Rac1 GTPases Differentially Regulate Agonist-Receptor Mediated Reactive Oxygen Species Generation in Platelets. PloS one, 11 9, e0163227
Peer Reviewed Publications Zhang, Dongsheng; Tang, Wenjuan; Niu, Haitao; Tse, William; Ruan, Hai-Bin; Dolznig, Helmut; Knösel, Thomas; Karl-Heinz, Friedrich; Themanns, Madeleine; Wang, Jiang; Song, Mingquan; Denson, Lee; Kenner, Lukas; Moriggl, Richard; Zheng, Yi; Han, Xiaonan 2024. Monogenic deficiency in murine intestinal Cdc42 leads to mucosal inflammation that induces crypt dysplasia. Genes & diseases, 11 1, 413-429Dandamudi, Akhila; Akbar, Huzoor; Cancelas, Jose; Zheng, Yi 2023. Rho GTPase Signaling in Platelet Regulation and Implication for Antiplatelet Therapies. International journal of molecular sciences, 24 3, Dandamudi, Akhila; Seibel, William; Tourdot, Benjamin; Cancelas, Jose A; Akbar, Huzoor; Zheng, Yi 2023. Structure-Activity Relationship Analysis of Rhosin, a RhoA GTPase Inhibitor, Reveals a New Class of Antiplatelet Agents. International journal of molecular sciences, 24 4, Fan, Cuiqing; Wunderlich, Mark; Cai, Xiongwei; Yan, Zijun; Zhang, Feng; Davis, Ashley Kuenzi; Xu, Lingli; Guo, Fukun; Lu, Q Richard; Azam, Mohammad; Tian, Weidong; Zheng, Yi 2023. Kinase-independent role of mTOR and on-/off-target effects of an mTOR kinase inhibitor. Leukemia, 37 10, 2073-2081Katayama, Kei-Ichi; Zheng, Yi; Inoue, Norimitsu 2023. Rac is required for the survival of cortical neurons. Experimental neurology, 361 , 114316Li, Yuehuan; Martin, Taylor Elijah; Hancock, Jonathan Matthew; Li, Rong; Viswanathan, Suvitha; Lydon, John P; Zheng, Yi; Ye, Xiaoqin 2023. Visualization of preimplantation uterine fluid absorption in mice using Alexa Fluor™ 488 Hydrazide†. Biology of reproduction, 108 2, 204-217Modur, Vishnu; Muhammad, Belal; Yang, Jun-Qi; Zheng, Yi; Komurov, Kakajan; Guo, Fukun 2023. Mechanism of inert inflammation in an immune checkpoint blockade-resistant tumor subtype bearing transcription elongation defects. Cell reports, 42 4, 112364Wang, Chen; Tu, Zhaowei; Cai, Xiongwei; Wang, Weinan; Davis, Ashely K; Nattamai, Kalpana; Paranjpe, Aditi; Dexheimer, Philip; Wu, Jianqiang; Huang, Frank Lei; Geiger, Hartmut; Huang, Gang; Zheng, Yi 2023. A critical role of RUNX1 in governing megakaryocyte-primed hematopoietic stem cell differentiation. Blood advances, 7 11, 2590-2605Zhang, Cuiping; Cui, Xiaojing; Liu, Yi; Wang, Fang; Signer, Robert; Nattamai, Kapana; Zhou, Daohong; Zheng, Yi; Geiger, Hartmut; Wan, Fengyi; Liang, Ying 2023. Latexin deletion protects against radiation-induced hematopoietic damages via selective activation of Bcl-2 prosurvival pathway. Haematologica, 108 12, 3464-3470Akwii, Racheal Grace; Sajib, Md Sanaullah; Zahra, Fatema Tuz; Tullar, Paul; Zabet-Moghaddam, Masoud; Zheng, Yi; Silvio Gutkind, J; Doci, Colleen L; Mikelis, Constantinos M 2022. Angiopoietin-2-induced lymphatic endothelial cell migration drives lymphangiogenesis via the β1 integrin-RhoA-formin axis. Angiogenesis, 25 3, 373-396Amoah, Amanda; Keller, Anja; Emini, Ramiz; Hoenicka, Markus; Liebold, Andreas; Vollmer, Angelika; Eiwen, Karina; Soller, Karin; Sakk, Vadim; Zheng, Yi; Florian, Maria Carolina; Geiger, Hartmut 2022. Aging of human hematopoietic stem cells is linked to changes in Cdc42 activity. Haematologica, 107 2, 393-402Hegde, Shailaja; Gasilina, Anjelika; Wunderlich, Mark; Lin, Yuan; Buchholzer, Marcel; Krumbach, Oliver H F; Akbarzadeh, Mohammad; Ahmadian, Mohammad Reza; Seibel, William; Zheng, Yi; Perentesis, John P; Mizukawa, Benjamin E; Vinnedge, Lisa Privette; Cancelas, José A; Nassar, Nicolas N 2022. Inhibition of the RacGEF VAV3 by the small molecule IODVA1 impedes RAC signaling and overcomes resistance to tyrosine kinase inhibition in acute lymphoblastic leukemia. Leukemia, 36 3, 637-647Hegde, Shailaja; Zheng, Yi; Cancelas, Jose A 2022. Novel blood derived hemostatic agents for bleeding therapy and prophylaxis. Current opinion in hematology, 29 6, 281-289Kalim, Khalid W; Yang, Jun-Qi; Wunderlich, Mark; Modur, Vishnu; Nguyen, Phuong; Li, Yuan; Wen, Ting; Davis, Ashley Kuenzi; Verma, Ravinder; Lu, Qing Richard; Jegga, Anil G; Zheng, Yi; Guo, Fukun 2022. Targeting of Cdc42 GTPase in regulatory T cells unleashes antitumor T-cell immunity. Journal for immunotherapy of cancer, 10 11, Katayama, Kei-Ichi; Zheng, Yi; Inoue, Norimitsu 2022. Rac-deficient cerebellar granule neurons die before they migrate to the internal granule layer. Scientific reports, 12 1, 14848Kim, Kee-Beom; Kim, Dong-Wook; Kim, Youngchul; Tang, Jun; Kirk, Nicole; Gan, Yongyu; Kim, Bongjun; Fang, Bingliang; Park, Jae-Ll; Zheng, Yi; Park, Kwon-Sik 2022. WNT5A-RHOA Signaling Is a Driver of Tumorigenesis and Represents a Therapeutically Actionable Vulnerability in Small Cell Lung Cancer. Cancer research, 82 22, 4219-4233Kim, Young-Woong; Zara, Greta; Kang, HyunJun; Branciamore, Sergio; O'Meally, Denis; Feng, Yuxin; Kuan, Chia-Yi; Luo, Yingjun; Nelson, Michael S; Brummer, Alex B; Rockne, Russell; Chen, Zhen Bouman; Zheng, Yi; Cardoso, Angelo A; Carlesso, Nadia 2022. Integration of single-cell transcriptomes and biological function reveals distinct behavioral patterns in bone marrow endothelium. Nature communications, 13 1, 7235Montserrat-Vazquez, Sara; Ali, Noelle J; Matteini, Francesca; Lozano, Javier; Zhaowei, Tu; Mejia-Ramirez, Eva; Marka, Gina; Vollmer, Angelika; Soller, Karin; Sacma, Mehmet; Sakk, Vadim; Mularoni, Loris; Mallm, Jan Philipp; Plass, Mireya; Zheng, Yi; Geiger, Hartmut; Florian, M Carolina 2022. Transplanting rejuvenated blood stem cells extends lifespan of aged immunocompromised mice. NPJ Regenerative medicine, 7 1, 78Nalapareddy, Kodandaramireddy; Zheng, Yi; Geiger, Hartmut 2022. Aging of intestinal stem cells. Stem cell reports, 17 4, 734-740Romano, Laurel; Seu, Katie G; Papoin, Julien; Muench, David E; Konstantinidis, Diamantis; Olsson, André; Schlum, Katrina; Chetal, Kashish; Chasis, Joel Anne; Mohandas, Narla; Barnes, Betsy J; Zheng, Yi; Grimes, H Leighton; Salomonis, Nathan; Blanc, Lionel; Kalfa, Theodosia A 2022. Erythroblastic islands foster granulopoiesis in parallel to terminal erythropoiesis. Blood, 140 14, 1621-1634Tu, Zhaowei; Fan, Cuiqing; Davis, Ashely K; Hu, Mengwen; Wang, Chen; Dandamudi, Akhila; Seu, Katie G; Kalfa, Theodosia A; Lu, Q Richard; Zheng, Yi 2022. Autism-associated chromatin remodeler CHD8 regulates erythroblast cytokinesis and fine-tunes the balance of Rho GTPase signaling. Cell reports, 40 2, 111072Tu, Zhaowei; Zheng, Yi 2022. Role of ATP-dependent chromatin remodelers in hematopoietic stem and progenitor cell maintenance. Current opinion in hematology, 29 4, 174-180Zhang, Zheng; Zhang, Feng; Davis, Ashley Kuenzi; Xin, Mei; Walz, Gerd; Tian, Weidong; Zheng, Yi 2022. CDC42 controlled apical-basal polarity regulates intestinal stem cell to transit amplifying cell fate transition via YAP-EGF-mTOR signaling. Cell reports, 38 2, 110009Chlon, Timothy M; Stepanchick, Emily; Hershberger, Courtney E; Daniels, Noah J; Hueneman, Kathleen M; Kuenzi Davis, Ashley; Choi, Kwangmin; Zheng, Yi; Gurnari, Carmelo; Haferlach, Torsten; Padgett, Richard A; Maciejewski, Jaroslaw P; Starczynowski, Daniel T 2021. Germline DDX41 mutations cause ineffective hematopoiesis and myelodysplasia. Cell stem cell, 28 11, 1966-1981.e6Duan, Xin; Perveen, Rehana; Dandamudi, Akhila; Adili, Reheman; Johnson, James; Funk, Kevin; Berryman, Mark; Davis, Ashley Kuenzi; Holinstat, Michael; Zheng, Yi; Akbar, Huzoor 2021. Pharmacologic targeting of Cdc42 GTPase by a small molecule Cdc42 activity-specific inhibitor prevents platelet activation and thrombosis. Scientific reports, 11 1, 13170Fan, Cuiqing; Zhao, Chuntao; Zhang, Feng; Kesarwani, Meenu; Tu, Zhaowei; Cai, Xiongwei; Davis, Ashley Kuenzi; Xu, Lingli; Hochstetler, Cindy L; Chen, Xiaoyi; Guo, Fukun; Huang, Gang; Azam, Mohammad; Tian, Weidong; Lu, Q Richard; Zheng, Yi 2021. Adaptive responses to mTOR gene targeting in hematopoietic stem cells reveal a proliferative mechanism evasive to mTOR inhibition. Proceedings of the National Academy of Sciences of the United States of America, 118 1, Fan, Yuping; Teng, Yan; Loison, Fabien; Pang, Aiming; Kasorn, Anongnard; Shao, Xinqi; Zhang, Cunling; Ren, Qian; Yu, Hongbo; Zheng, Yi; Cancelas, Jose A; Manis, John; Chai, Li; Park, Shin-Young; Zhao, Li; Xu, Yuanfu; Feng, Sizhou; Silberstein, Leslie E; Ma, Fengxia; Luo, Hongbo R 2021. Targeting multiple cell death pathways extends the shelf life and preserves the function of human and mouse neutrophils for transfusion. Science translational medicine, 13 604, Guidi, Novella; Marka, Gina; Sakk, Vadim; Zheng, Yi; Florian, Maria Carolina; Geiger, Hartmut 2021. An aged bone marrow niche restrains rejuvenated hematopoietic stem cells. Stem cells (Dayton, Ohio), 39 8, 1101-1106Hegde, Shailaja; Wellendorf, Ashley M; Zheng, Yi; Cancelas, Jose A 2021. Antioxidant prevents clearance of hemostatically competent platelets after long-term cold storage. Transfusion, 61 2, 557-567Kalim, Khalid W; Yang, Jun-Qi; Modur, Vishnu; Nguyen, Phuong; Li, Yuan; Zheng, Yi; Guo, Fukun 2021. Graded RhoA GTPase Expression in Treg Cells Distinguishes Tumor Immunity From Autoimmunity. Frontiers in immunology, 12 , 726393Kandi, Ravinder; Senger, Katharina; Grigoryan, Ani; Soller, Karin; Sakk, Vadim; Schuster, Tanja; Eiwen, Karina; Menon, Manoj B; Gaestel, Matthias; Zheng, Yi; Florian, Maria Carolina; Geiger, Hartmut 2021. Cdc42-Borg4-Septin7 axis regulates HSC polarity and function. EMBO reports, 22 12, e52931Lin, Yuan; Lu, Shaoyong; Zhang, Jian; Zheng, Yi 2021. Structure of an inactive conformation of GTP-bound RhoA GTPase. Structure (London, England : 1993), 29 6, 553-563.e5Lin, Yuan; Watanabe-Chailland, Miki; Zheng, Yi 2021. Protocol for structural and biochemical analyses of RhoA GTPase. STAR protocols, 2 2, 100541Nakamura, Yuka; Ueno, Masaki; Niehaus, Jesse K; Lang, Richard A; Zheng, Yi; Yoshida, Yutaka 2021. Modulation of Both Intrinsic and Extrinsic Factors Additively Promotes Rewiring of Corticospinal Circuits after Spinal Cord Injury. The Journal of neuroscience : the official journal of the Society for Neuroscience, 41 50, 10247-10260Nalapareddy, Kodandaramireddy; Hassan, Aishlin; Sampson, Leesa L; Zheng, Yi; Geiger, Hartmut 2021. Suppression of elevated Cdc42 activity promotes the regenerative potential of aged intestinal stem cells. iScience, 24 4, 102362Sertorio, Mathieu; Nowrouzi, Ali; Akbarpour, Mahdi; Chetal, Kashish; Salomonis, Nathan; Brons, Stephan; Mascia, Anthony; Ionascu, Dan; McCauley, Shelby; Kupneski, Taylor; Köthe, Andreas; Debus, Jürgen; Perentesis, John P; Abdollahi, Amir; Zheng, Yi; Wells, Susanne I 2021. Differential transcriptome response to proton versus X-ray radiation reveals novel candidate targets for combinatorial PT therapy in lymphoma. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 155 , 293-303Sheng, Yue; Ma, Rui; Yu, Chunjie; Wu, Qiong; Zhang, Steven; Paulsen, Kimberly; Zhang, Jiwang; Ni, Hongyu; Huang, Yong; Zheng, Yi; Qian, Zhijian 2021. Role of c-Myc haploinsufficiency in the maintenance of HSCs in mice. Blood, 137 5, 610-623Tu, Zhaowei; Wang, Chen; Davis, Ashley K; Hu, Mengwen; Zhao, Chuntao; Xin, Mei; Lu, Q Richard; Zheng, Yi 2021. The chromatin remodeler CHD8 governs hematopoietic stem/progenitor survival by regulating ATM-mediated P53 protein stability. Blood, 138 3, 221-233Zhang, Bin; Nguyen, Le Xuan Truong; Zhao, Dandan; Frankhouser, David E; Wang, Huafeng; Hoang, Dinh Hoa; Qiao, Junjing; Abundis, Christina; Brehove, Matthew; Su, Yu-Lin; Feng, Yuxin; Stein, Anthony; Ghoda, Lucy; Dorrance, Adrianne; Perrotti, Danilo; Chen, Zhen; Han, Anjia; Pichiorri, Flavia; Jin, Jie; Jovanovic-Talisman, Tijana; Caligiuri, Michael A; Kuo, Calvin J; Yoshimura, Akihiko; Li, Ling; Rockne, Russell C; Kortylewski, Marcin; Zheng, Yi; Carlesso, Nadia; Kuo, Ya-Huei; Marcucci, Guido 2021. Treatment-induced arteriolar revascularization and miR-126 enhancement in bone marrow niche protect leukemic stem cells in AML. Journal of hematology & oncology, 14 1, 122Zhang, Zheng; Liu, Ming; Zheng, Yi 2021. Role of Rho GTPases in stem cell regulation. Biochemical Society transactions, 49 6, 2941-2955Althoff, Mark; Nayak, Ramesh; Hegde, Shailaja; Wellendorf, Ashley; Bohan, Breanna; Filippi, Marie-Dominique; Xin, Mei; Lu, Richard; Geiger, Hartmut; Zheng, Yi; Diaz-Meco, Maria T; Moscat, Jorge; Cancelas, Jose A 2020. Yap1-Scribble polarization is required for hematopoietic stem cell division and fate. Blood, , Florian, Maria Carolina; Leins, Hanna; Gobs, Michael; Han, Yang; Marka, Gina; Soller, Karin; Vollmer, Angelika; Sakk, Vadim; Nattamai, Kalpana J; Rayes, Ahmad; Zhao, Xueheng; Setchell, Kenneth; Mulaw, Medhanie; Wagner, Wolfgang; Zheng, Yi; Geiger, Hartmut 2020. Inhibition of Cdc42 activity extends lifespan and decreases circulating inflammatory cytokines in aged female C57BL/6 mice. Aging cell, , e13208Muto, Tomoya; Walker, Callum S; Choi, Kwangmin; Hueneman, Kathleen; Smith, Molly A; Gul, Zartash; Garcia-Manero, Guillermo; Ma, Averil; Zheng, Yi; Starczynowski, Daniel T 2020. Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs. Nature immunology, 21 5, 535-545Papaioannou, Dimitrios; Petri, Andreas; Dovey, Oliver M; Terreri, Sara; Wang, Eric; Collins, Frances A; Woodward, Lauren A; Walker, Allison E; Nicolet, Deedra; Pepe, Felice; Kumchala, Prasanthi; Bill, Marius; Walker, Christopher J; Karunasiri, Malith; Mrózek, Krzysztof; Gardner, Miranda L; Camilotto, Virginia; Zitzer, Nina; Cooper, Jonathan L; Cai, Xiongwei; Rong-Mullins, Xiaoqing; Kohlschmidt, Jessica; Archer, Kellie J; Freitas, Michael A; Zheng, Yi; Lee, Robert J; Aifantis, Iannis; Vassiliou, George; Singh, Guramrit; Kauppinen, Sakari; Bloomfield, Clara D; Dorrance, Adrienne M; Garzon, Ramiro 2020. Author Correction: The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia. Nature communications, 11 1, 3878Papaioannou, Dimitrios; Petri, Andreas; Dovey, Oliver M; Terreri, Sara; Wang, Eric; Collins, Frances A; Woodward, Lauren A; Walker, Allison E; Nicolet, Deedra; Pepe, Felice; Kumchala, Prasanthi; Bill, Marius; Walker, Christopher J; Karunasiri, Malith; Mrózek, Krzysztof; Gardner, Miranda L; Camilotto, Virginia; Zitzer, Nina; Cooper, Jonathan L; Cai, Xiongwei; Rong-Mullins, Xiaoqing; Kohlschmidt, Jessica; Archer, Kellie J; Freitas, Michael A; Zheng, Yi; Lee, Robert J; Aifantis, Iannis; Vassiliou, George; Singh, Guramrit; Kauppinen, Sakari; Bloomfield, Clara D; Dorrance, Adrienne M; Garzon, Ramiro 2020. Publisher Correction: The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia. Nature communications, 11 1, 204Sheng, Yue; Ma, Rui; Yu, Chunjie; Wu, Qiong; Zhang, Steven; Paulsen, Kimberly; Zhang, Jiwang; Ni, Hongyu; Huang, Yong; Zheng, Yi; Qian, Zhijian 2020. Role of c-Myc haploinsufficiency in the maintenance of HSCs. Blood, , Sheng, Yue; Ma, Rui; Yu, Chunjie; Wu, Qiong; Zhang, Steven; Paulsen, Kimberly; Zhang, Jiwang; Ni, Hongyu; Huang, Yong; Zheng, Yi; Qian, Zhijian 2020. Role of c-Myc haploinsufficiency in the maintenance of HSCs. Blood, , Hochstetler, Cindy L; Feng, Yuxin; Sacma, Mehmet; Davis, Ashley K; Rao, Mahil; Kuan, Chia-Yi; You, Li-Ru; Geiger, Hartmut; Zheng, Yi 2019. KRasG12D expression in the bone marrow vascular niche affects hematopoiesis with inflammatory signals. Experimental hematology, , Nayak, R C; Hegde, S; Althoff, M J; Wellendorf, A M; Mohmoud, F; Perentesis, J; Reina-Campos, M; Reynaud, D; Zheng, Y; Diaz-Meco, M T; Moscat, J; Cancelas, J A 2019. The signaling axis atypical protein kinase C ?/?-Satb2 mediates leukemic transformation of B-cell progenitors. Nature communications, 10 1, 46Nguyen, Phuong; Chakrabarti, Jayati; Li, Yuan; Kalim, Khalid W; Zhang, Mengnan; Zhang, Lin; Zheng, Yi; Guo, Fukun 2019. Rational Targeting of Cdc42 Overcomes Drug Resistance of Multiple Myeloma. Frontiers in oncology, 9 , 958Papaioannou, Dimitrios; Petri, Andreas; Dovey, Oliver M; Terreri, Sara; Wang, Eric; Collins, Frances A; Woodward, Lauren A; Walker, Allison E; Nicolet, Deedra; Pepe, Felice; Kumchala, Prasanthi; Bill, Marius; Walker, Christopher J; Karunasiri, Malith; Mrózek, Krzysztof; Gardner, Miranda L; Camilotto, Virginia; Zitzer, Nina; Cooper, Jonathan L; Cai, Xiongwei; Rong-Mullins, Xiaoqing; Kohlschmidt, Jessica; Archer, Kellie J; Freitas, Michael A; Zheng, Yi; Lee, Robert J; Aifantis, Iannis; Vassiliou, George; Singh, Guramrit; Kauppinen, Sakari; Bloomfield, Clara D; Dorrance, Adrienne M; Garzon, Ramiro 2019. The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia. Nature communications, 10 1, 5351Xie, Yangyang; Gao, Li; Xu, Chunhui; Chu, Liming; Gao, Lei; Wu, Ruichi; Liu, Yu; Liu, Ting; Sun, Xiao-Jian; Ren, Ruibao; Tang, Jingyan; Zheng, Yi; Zhou, Yong; Shen, Shuhong 2019. ARHGEF12 regulates erythropoiesis and is involved in erythroid regeneration after chemotherapy in acute lymphoblastic leukemia patients. Haematologica, , Yang, Jun-Qi; Kalim, Khalid W; Li, Yuan; Duan, Xin; Nguyen, Phuong; Khurana Hershey, Gurjit K; Kroner, John; Ruff, Brandy; Zhang, Li; Salomonis, Nathan; Rochman, Mark; Wen, Ting; Zheng, Yi; Guo, Fukun 2019. Rational targeting Cdc42 restrains Th2 cell differentiation and prevents allergic airway inflammation. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 49 1, 92-107Yang, Jun-Qi; Kalim, Khalid W; Li, Yuan; Zheng, Yi; Guo, Fukun 2019. Ablation of RhoA impairs Th17 cell differentiation and alleviates house dust mite-triggered allergic airway inflammation. Journal of leukocyte biology, , Zahra, Fatema Tuz; Sajib, Md Sanaullah; Ichiyama, Yusuke; Akwii, Racheal Grace; Tullar, Paul E; Cobos, Christopher; Minchew, Shelby A; Doçi, Colleen L; Zheng, Yi; Kubota, Yoshiaki; Gutkind, J Silvio; Mikelis, Constantinos M 2019. Endothelial RhoA GTPase is essential for in vitro endothelial functions but dispensable for physiological in vivo angiogenesis. Scientific reports, 9 1, 11666Zhang, Cuiping; Fondufe-Mittendorf, Yvonne N; Wang, Chi; Chen, Jin; Cheng, Qiang; Zhou, Daohong; Zheng, Yi; Geiger, Hartmut; Liang, Ying 2019. Latexin regulation by HMGB2 is required for hematopoietic stem cell maintenance. Haematologica, , Zhou, Wei; Yang, Yingying; Mei, Congjin; Dong, Panpan; Mu, Shasha; Wu, Hongchu; Zhou, Yonghua; Zheng, Yi; Guo, Fukun; Yang, Jun-Qi 2019. Inhibition of Rho-Kinase Downregulates Th17 Cells and Ameliorates Hepatic Fibrosis by Schistosoma japonicum Infection. Cells, 8 10, Akbar, H; Duan, X; Piatt, R; Saleem, S; Davis, A K; Tandon, N N; Bergmeier, W; Zheng, Y 2018. Small molecule targeting the Rac1-NOX2 interaction prevents collagen-related peptide and thrombin-induced reactive oxygen species generation and platelet activation. Journal of thrombosis and haemostasis : JTH, 16 10, 2083-2096Cai, Xiongwei; Zheng, Yi; Speck, Nancy A 2018. A Western Blotting Protocol for Small Numbers of Hematopoietic Stem Cells. Journal of visualized experiments : JoVE, 138, Cai, Xiongwei; Zhou, Xuan; Zheng, Yi 2018. In Vivo Rescue Assay of RhoA-Deficient Hematopoietic Stem and Progenitor Cells. Methods in molecular biology (Clifton, N.J.), 1821 , 247-256Chadwick, Michelle L; Lane, Adam; Thomas, Dana; Smith, Amanda R; White, Angela R; Davidson, Dominique; Feng, Yuxin; Boscolo, Elisa; Zheng, Yi; Adams, Denise M; Gupta, Anita; Veillette, André; Chow, Lionel M L 2018. Combined mTOR and MEK inhibition is an effective therapy in a novel mouse model for angiosarcoma. Oncotarget, 9 37, 24750-24765Du, Wei; Liu, Wei; Mizukawa, Benjamin; Shang, Xun; Sipple, Jared; Wunderlich, Mark; Geiger, Hartmut; Davies, Stella; Mulloy, James; Pang, Qishen; Zheng, Yi 2018. A non-myeloablative conditioning approach for long-term engraftment of human and mouse hematopoietic stem cells. Leukemia, 32 9, 2041-2046Fang, Jing; Muto, Tomoya; Kleppe, Maria; Bolanos, Lyndsey C; Hueneman, Kathleen M; Walker, Callum S; Sampson, Leesa; Wellendorf, Ashley M; Chetal, Kashish; Choi, Kwangmin; Salomonis, Nathan; Choi, Yongwon; Zheng, Yi; Cancelas, Jose A; Levine, Ross L; Starczynowski, Daniel T 2018. TRAF6 Mediates Basal Activation of NF-?B Necessary for Hematopoietic Stem Cell Homeostasis. Cell reports, 22 5, 1250-1262Florian, M Carolina; Klose, Markus; Sacma, Mehmet; Jablanovic, Jelena; Knudson, Luke; Nattamai, Kalpana J; Marka, Gina; Vollmer, Angelika; Soller, Karin; Sakk, Vadim; Cabezas-Wallscheid, Nina; Zheng, Yi; Mulaw, Medhanie A; Glauche, Ingmar; Geiger, Hartmut 2018. Aging alters the epigenetic asymmetry of HSC division. PLoS biology, 16 9, e2003389Grigoryan, Ani; Guidi, Novella; Senger, Katharina; Liehr, Thomas; Soller, Karin; Marka, Gina; Vollmer, Angelika; Markaki, Yolanda; Leonhardt, Heinrich; Buske, Christian; Lipka, Daniel B; Plass, Christoph; Zheng, Yi; Mulaw, Medhanie A; Geiger, Hartmut; Florian, Maria Carolina 2018. LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells. Genome biology, 19 1, 189Hayashi, Yoshihiro; Zhang, Yue; Yokota, Asumi; Yan, Xiaomei; Liu, Jinqin; Choi, Kwangmin; Li, Bing; Sashida, Goro; Peng, Yanyan; Xu, Zefeng; Huang, Rui; Zhang, Lulu; Freudiger, George M; Wang, Jingya; Dong, Yunzhu; Zhou, Yile; Wang, Jieyu; Wu, Lingyun; Bu, Jiachen; Chen, Aili; Zhao, Xinghui; Sun, Xiujuan; Chetal, Kashish; Olsson, Andre; Watanabe, Miki; Romick-Rosendale, Lindsey E; Harada, Hironori; Shih, Lee-Yung; Tse, William; Bridges, James P; Caligiuri, Michael A; Huang, Taosheng; Zheng, Yi; Witte, David P; Wang, Qian-Fei; Qu, Cheng-Kui; Salomonis, Nathan; Grimes, H Leighton; Nimer, Stephen D; Xiao, Zhijian; Huang, Gang 2018. Pathobiological Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes. Cancer discovery, 8 11, 1438-1457Hegde, Shailaja; Akbar, Huzoor; Zheng, Yi; Cancelas, Jose A 2018. Towards increasing shelf life and haemostatic potency of stored platelet concentrates. Current opinion in hematology, 25 6, 500-508Jiang, Xi; Hu, Chao; Ferchen, Kyle; Nie, Ji; Cui, Xiaolong; Chen, Chih-Hong; Cheng, Liting; Zuo, Zhixiang; Seibel, William; He, Chunjiang; Tang, Yixuan; Skibbe, Jennifer R; Wunderlich, Mark; Reinhold, William C; Dong, Lei; Shen, Chao; Arnovitz, Stephen; Ulrich, Bryan; Lu, Jiuwei; Weng, Hengyou; Su, Rui; Huang, Huilin; Wang, Yungui; Li, Chenying; Qin, Xi; Mulloy, James C; Zheng, Yi; Diao, Jiajie; Jin, Jie; Li, Chong; Liu, Paul P; He, Chuan; Chen, Yuan; Chen, Jianjun 2018. Author Correction: Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia. Nature communications, 9 1, 670Kalim, Khalid W; Yang, Jun-Qi; Li, Yuan; Meng, Yan; Zheng, Yi; Guo, Fukun 2018. Reciprocal Regulation of Glycolysis-Driven Th17 Pathogenicity and Regulatory T Cell Stability by Cdc42. Journal of immunology (Baltimore, Md. : 1950), 200 7, 2313-2326Liu, Wei; Du, Wei; Shang, Xun; Wang, Lei; Evelyn, Chris; Florian, Maria Carolina; A Ryan, Marnie; Rayes, Ahmad; Zhao, Xueheng; Setchell, Kenneth; Meller, Jarek; Guo, Fukun; Nassar, Nicolas; Geiger, Hartmut; Pang, Qishen; Zheng, Yi 2018. Rational identification of a Cdc42 inhibitor presents a new regimen for long-term hematopoietic stem cell mobilization. Leukemia, , Lv, Jiawen; Zeng, Junchao; Guo, Fukun; Li, Yiran; Xu, Mengying; Cheng, Yuanxiong; Zhang, Lin; Cai, Shaoxi; Chen, Yinghua; Zheng, Yi; Hu, Guodong 2018. Endothelial Cdc42 deficiency impairs endothelial regeneration and vascular repair after inflammatory vascular injury. Respiratory research, 19 1, 27Maliken, Bryan D; Kanisicak, Onur; Karch, Jason; Khalil, Hadi; Fu, Xing; Boyer, Justin G; Prasad, Vikram; Zheng, Yi; Molkentin, Jeffery D 2018. Gata4-Dependent Differentiation of c-Kit+ Derived Endothelial Cells Underlies Artefactual Cardiomyocyte Regeneration in the Heart. Circulation, , Mizukawa, Benjamin; O'Brien, Eric; Mulloy, James C; Zheng, Yi 2018. Cell Polarity and Division Symmetry Analyses in Transformed Blood Cells. Methods in molecular biology (Clifton, N.J.), 1821 , 257-266Sertorio, Mathieu; Perentesis, John P; Vatner, Ralph E; Mascia, Anthony E; Zheng, Yi; Wells, Susanne I 2018. Cancer Cell Metabolism: Implications for X-ray and Particle Radiation Therapy. International journal of particle therapy, 5 1, 40-48Wu, Lai Man Natalie; Deng, Yaqi; Wang, Jincheng; Zhao, Chuntao; Wang, Jiajia; Rao, Rohit; Xu, Lingli; Zhou, Wenhao; Choi, Kwangmin; Rizvi, Tilat A; Remke, Marc; Rubin, Joshua B; Johnson, Randy L; Carroll, Thomas J; Stemmer-Rachamimov, Anat O; Wu, Jianqiang; Zheng, Yi; Xin, Mei; Ratner, Nancy; Lu, Q Richard 2018. Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis. Cancer cell, 33 2, 292-308.e7Yang, Yingying; Dong, Panpan; Zhao, Jing; Zhou, Wei; Zhou, Yonghua; Xu, Yongliang; Mei, Congjin; Guo, Fukun; Zheng, Yi; Yang, Jun-Qi 2018. PKC?/? regulates Th17 differentiation and house dust mite-induced allergic airway inflammation. Biochimica et biophysica acta, 1864 3, 934-941Chen, Xiaoyi; Clark, Jason; Wunderlich, Mark; Fan, Cuiqing; Davis, Ashley; Chen, Song; Guan, Jun-Lin; Mulloy, James C; Kumar, Ashish; Zheng, Yi 2017. Autophagy is dispensable for Kmt2a/Mll-Mllt3/Af9 AML maintenance and anti-leukemic effect of chloroquine. Autophagy, 13 5, 955-966El Zowalaty, Ahmed E; Li, Rong; Zheng, Yi; Lydon, John P; DeMayo, Francesco J; Ye, Xiaoqin 2017. Deletion of RhoA in Progesterone Receptor-Expressing Cells Leads to Luteal Insufficiency and Infertility in Female Mice. Endocrinology, 158 7, 2168-2178Fang, Jing; Bolanos, Lyndsey C; Choi, Kwangmin; Liu, Xiaona; Christie, Susanne; Akunuru, Shailaja; Kumar, Rupali; Wang, Dehua; Chen, Xiaoting; Greis, Kenneth D; Stoilov, Peter; Filippi, Marie-Dominique; Maciejewski, Jaroslaw P; Garcia-Manero, Guillermo; Weirauch, Matthew T; Salomonis, Nathan; Geiger, Hartmut; Zheng, Yi; Starczynowski, Daniel T 2017. Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia. Nature immunology, 18 2, 236-245Guo, Fukun; Zheng, Yi 2017. Vav1: Friend and Foe of Cancer. Trends in cell biology, 27 12, 879-880Hato, Takashi; Winfree, Seth; Day, Richard; Sandoval, Ruben M; Molitoris, Bruce A; Yoder, Mervin C; Wiggins, Roger C; Zheng, Yi; Dunn, Kenneth W; Dagher, Pierre C 2017. Two-Photon Intravital Fluorescence Lifetime Imaging of the Kidney Reveals Cell-Type Specific Metabolic Signatures. Journal of the American Society of Nephrology : JASN, 28 8, 2420-2430Jiang, Xi; Hu, Chao; Ferchen, Kyle; Nie, Ji; Cui, Xiaolong; Chen, Chih-Hong; Cheng, Liting; Zuo, Zhixiang; Seibel, William; He, Chunjiang; Tang, Yixuan; Skibbe, Jennifer R; Wunderlich, Mark; Reinhold, William C; Dong, Lei; Shen, Chao; Arnovitz, Stephen; Ulrich, Bryan; Lu, Jiuwei; Weng, Hengyou; Su, Rui; Huang, Huilin; Wang, Yungui; Li, Chenying; Qin, Xi; Mulloy, James C; Zheng, Yi; Diao, Jiajie; Jin, Jie; Li, Chong; Liu, Paul P; He, Chuan; Chen, Yuan; Chen, Jianjun 2017. Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia. Nature communications, 8 1, 2099Kalim, Khalid W; Zhang, Shuangmin; Chen, Xiaoyi; Li, Yuan; Yang, Jun-Qi; Zheng, Yi; Guo, Fukun 2017. mTOR has a developmental stage-specific role in mitochondrial fitness independent of conventional mTORC1 and mTORC2 and the kinase activity. PloS one, 12 8, e0183266Li, Jingjing; Miao, Lianjie; Zhao, Chen; Shaikh Qureshi, Wasay Mohiuddin; Shieh, David; Guo, Hua; Lu, Yangyang; Hu, Saiyang; Huang, Alice; Zhang, Lu; Cai, Chen-Leng; Wan, Leo Q; Xin, Hongbo; Vincent, Peter; Singer, Harold A; Zheng, Yi; Cleaver, Ondine; Fan, Zhen-Chuan; Wu, Mingfu 2017. CDC42 is required for epicardial and pro-epicardial development by mediating FGF receptor trafficking to the plasma membrane. Development (Cambridge, England), 144 9, 1635-1647Liu, Ming; Zhang, Zheng; Sampson, Leesa; Zhou, Xuan; Nalapareddy, Kodandaramireddy; Feng, Yuxin; Akunuru, Shailaja; Melendez, Jaime; Davis, Ashley Kuenzi; Bi, Feng; Geiger, Hartmut; Xin, Mei; Zheng, Yi 2017. RHOA GTPase Controls YAP-Mediated EREG Signaling in Small Intestinal Stem Cell Maintenance. Stem cell reports, 9 6, 1961-1975Mizukawa, Benjamin; O'Brien, Eric; Moreira, Daniel C; Wunderlich, Mark; Hochstetler, Cindy L; Duan, Xin; Liu, Wei; Orr, Emily; Grimes, H Leighton; Mulloy, James C; Zheng, Yi 2017. The cell polarity determinant CDC42 controls division symmetry to block leukemia cell differentiation. Blood, 130 11, 1336-1346Nalapareddy, Kodandaramireddy; Nattamai, Kalpana J; Kumar, Rupali S; Karns, Rebekah; Wikenheiser-Brokamp, Kathryn A; Sampson, Leesa L; Mahe, Maxime M; Sundaram, Nambirajan; Yacyshyn, Mary-Beth; Yacyshyn, Bruce; Helmrath, Michael A; Zheng, Yi; Geiger, Hartmut 2017. Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells. Cell reports, 18 11, 2608-2621Qiu, Sugan; Fan, Xiaolin; Yang, Yingying; Dong, Panpan; Zhou, Wei; Xu, Yongliang; Zhou, Yonghua; Guo, Fukun; Zheng, Yi; Yang, Jun-Qi 2017. Schistosoma japonicum infection downregulates house dust mite-induced allergic airway inflammation in mice. PloS one, 12 6, e0179565Sakabe, Masahide; Fan, Jieqing; Odaka, Yoshinobu; Liu, Ning; Hassan, Aishlin; Duan, Xin; Stump, Paige; Byerly, Luke; Donaldson, Megan; Hao, Jiukuan; Fruttiger, Marcus; Lu, Qing Richard; Zheng, Yi; Lang, Richard A; Xin, Mei 2017. YAP/TAZ-CDC42 signaling regulates vascular tip cell migration. Proceedings of the National Academy of Sciences of the United States of America, 114 41, 10918-10923Sinagoga, Katie L; Stone, William J; Schiesser, Jacqueline V; Schweitzer, Jamie I; Sampson, Leesa; Zheng, Yi; Wells, James M 2017. Distinct roles for the mTOR pathway in postnatal morphogenesis, maturation and function of pancreatic islets. Development (Cambridge, England), 144 13, 2402-2414Zandvakili, I; Lin, Y; Morris, J C; Zheng, Y 2017. Rho GTPases: Anti- or pro-neoplastic targets? Oncogene, 36 23, 3213-3222Barry, David M; Koo, Yeon; Norden, Pieter R; Wylie, Lyndsay A; Xu, Ke; Wichaidit, Chonlarat; Azizoglu, D Berfin; Zheng, Yi; Cobb, Melanie H; Davis, George E; Cleaver, Ondine 2016. Rasip1-Mediated Rho GTPase Signaling Regulates Blood Vessel Tubulogenesis via Nonmuscle Myosin II. Circulation research, 119 7, 810-26Imai, Fumiyasu; Ladle, David R; Leslie, Jennifer R; Duan, Xin; Rizvi, Tilat A; Ciraolo, Georgianne M; Zheng, Yi; Yoshida, Yutaka 2016. Synapse Formation in Monosynaptic Sensory-Motor Connections Is Regulated by Presynaptic Rho GTPase Cdc42. The Journal of neuroscience : the official journal of the Society for Neuroscience, 36 21, 5724-35Nohata, Nijiro; Uchida, Yutaka; Stratman, Amber N; Adams, Ralf H; Zheng, Yi; Weinstein, Brant M; Mukouyama, Yoh-Suke; Gutkind, J Silvio 2016. Temporal-specific roles of Rac1 during vascular development and retinal angiogenesis. Developmental biology, 411 2, 183-194O'Hayre, M; Inoue, A; Kufareva, I; Wang, Z; Mikelis, C M; Drummond, R A; Avino, S; Finkel, K; Kalim, K W; DiPasquale, G; Guo, F; Aoki, J; Zheng, Y; Lionakis, M S; Molinolo, A A; Gutkind, J S 2016. Inactivating mutations in GNA13 and RHOA in Burkitt's lymphoma and diffuse large B-cell lymphoma: a tumor suppressor function for the G?13/RhoA axis in B cells. Oncogene, 35 29, 3771-80Palazzo, A; Bluteau, O; Messaoudi, K; Marangoni, F; Chang, Y; Souquere, S; Pierron, G; Lapierre, V; Zheng, Y; Vainchenker, W; Raslova, H; Debili, N 2016. The cell division control protein 42-Src family kinase-neural Wiskott-Aldrich syndrome protein pathway regulates human proplatelet formation. Journal of thrombosis and haemostasis : JTH, 14 12, 2524-2535Sampson, Leesa L; Davis, Ashley K; Grogg, Matthew W; Zheng, Yi 2016. mTOR disruption causes intestinal epithelial cell defects and intestinal atrophy postinjury in mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 30 3, 1263-75Yang, Jun-Qi; Kalim, Khalid W; Li, Yuan; Zhang, Shuangmin; Hinge, Ashwini; Filippi, Marie-Dominique; Zheng, Yi; Guo, Fukun 2016. RhoA orchestrates glycolysis for TH2 cell differentiation and allergic airway inflammation. The Journal of allergy and clinical immunology, 137 1, 231-245.e4Barry, David M; Xu, Ke; Meadows, Stryder M; Zheng, Yi; Norden, Pieter R; Davis, George E; Cleaver, Ondine 2015. Cdc42 is required for cytoskeletal support of endothelial cell adhesion during blood vessel formation in mice. Development (Cambridge, England), 142 17, 3058-70Chang, Kyung Hee; Nayak, Ramesh C; Roy, Swarnava; Perumbeti, Ajay; Wellendorf, Ashley M; Bezold, Katie Y; Pirman, Megan; Hill, Sarah E; Starnes, Joseph; Loberg, Anastacia; Zhou, Xuan; Inagami, Tadashi; Zheng, Yi; Malik, Punam; Cancelas, Jose A 2015. Vasculopathy-associated hyperangiotensinemia mobilizes haematopoietic stem cells/progenitors through endothelial AT?R and cytoskeletal dysregulation. Nature communications, 6 , 5914Evelyn, Chris R; Biesiada, Jacek; Duan, Xin; Tang, Hong; Shang, Xun; Papoian, Ruben; Seibel, William L; Nelson, Sandra; Meller, Jaroslaw; Zheng, Yi 2015. Combined rational design and a high throughput screening platform for identifying chemical inhibitors of a Ras-activating enzyme. The Journal of biological chemistry, 290 20, 12879-98Kesarwani, Meenu; Huber, Erika; Kincaid, Zachary; Evelyn, Chris R; Biesiada, Jacek; Rance, Mark; Thapa, Mahendra B; Shah, Neil P; Meller, Jarek; Zheng, Yi; Azam, Mohammad 2015. Targeting substrate-site in Jak2 kinase prevents emergence of genetic resistance. Scientific reports, 5 , 14538Konstantinidis, Diamantis G; Giger, Katie M; Risinger, Mary; Pushkaran, Suvarnamala; Zhou, Ping; Dexheimer, Phillip; Yerneni, Satwica; Andreassen, Paul; Klingmüller, Ursula; Palis, James; Zheng, Yi; Kalfa, Theodosia A 2015. Cytokinesis failure in RhoA-deficient mouse erythroblasts involves actomyosin and midbody dysregulation and triggers p53 activation. Blood, 126 12, 1473-82Li, Juan; Zhang, Lei; Chen, Zhenzhong; Xie, Minjuan; Huang, Lu; Xue, Jinhua; Liu, Yutong; Liu, Nuyun; Guo, Fukun; Zheng, Yi; Kong, Jiming; Zhang, Lin; Zhang, Lu 2015. Cocaine activates Rac1 to control structural and behavioral plasticity in caudate putamen. Neurobiology of disease, 75 , 159-76Lin, Yuan; Zheng, Yi 2015. Approaches of targeting Rho GTPases in cancer drug discovery. Expert opinion on drug discovery, 10 9, 991-1010Mikelis, Constantinos M; Simaan, May; Ando, Koji; Fukuhara, Shigetomo; Sakurai, Atsuko; Amornphimoltham, Panomwat; Masedunskas, Andrius; Weigert, Roberto; Chavakis, Triantafyllos; Adams, Ralf H; Offermanns, Stefan; Mochizuki, Naoki; Zheng, Yi; Gutkind, J Silvio 2015. RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock. Nature communications, 6 , 6725Zandvakili, Inuk; Davis, Ashley Kuenzi; Hu, Guodong; Zheng, Yi 2015. Loss of RhoA Exacerbates, Rather Than Dampens, Oncogenic K-Ras Induced Lung Adenoma Formation in Mice. PloS one, 10 6, e0127923Delaney, Michael Keegan; Liu, Junling; Kim, Kyungho; Shen, Bo; Stojanovic-Terpo, Aleksandra; Zheng, Yi; Cho, Jaehyung; Du, Xiaoping 2014. Agonist-induced platelet procoagulant activity requires shear and a Rac1-dependent signaling mechanism. Blood, 124 12, 1957-67Evelyn, Chris R; Duan, Xin; Biesiada, Jacek; Seibel, William L; Meller, Jaroslaw; Zheng, Yi 2014. Rational design of small molecule inhibitors targeting the Ras GEF, SOS1. Chemistry & biology, 21 12, 1618-28Fabbiano, Salvatore; Menacho-Márquez, Mauricio; Sevilla, María A; Albarrán-Juárez, Julián; Zheng, Yi; Offermanns, Stefan; Montero, María J; Bustelo, Xosé R 2014. Genetic dissection of the vav2-rac1 signaling axis in vascular smooth muscle cells. Molecular and cellular biology, 34 24, 4404-19Geiger, Hartmut; Zheng, Yi 2014. Regulation of hematopoietic stem cell aging by the small RhoGTPase Cdc42. Experimental cell research, 329 2, 214-9Guo, F; Li, J; Zhang, S; Du, W; Amarachintha, S; Sipple, J; Phelan, J; Grimes, H L; Zheng, Y; Pang, Q 2014. mTOR kinase inhibitor sensitizes T-cell lymphoblastic leukemia for chemotherapy-induced DNA damage via suppressing FANCD2 expression. Leukemia, 28 1, 203-6Kalfa, Theodosia A; Zheng, Yi 2014. Rho GTPases in erythroid maturation. Current opinion in hematology, 21 3, 165-71Konstantinidis, Diamantis G; Pushkaran, Suvarnamala; Giger, Katie; Manganaris, Stefanos; Zheng, Yi; Kalfa, Theodosia A 2014. Identification of a murine erythroblast subpopulation enriched in enucleating events by multi-spectral imaging flow cytometry. Journal of visualized experiments : JoVE, 88, Sakamori, Ryotaro; Yu, Shiyan; Zhang, Xiao; Hoffman, Andrew; Sun, Jiaxin; Das, Soumyashree; Vedula, Pavan; Li, Guangxun; Fu, Jiang; Walker, Francesca; Yang, Chung S; Yi, Zheng; Hsu, Wei; Yu, Da-Hai; Shen, Lanlan; Rodriguez, Alexis J; Taketo, Makoto M; Bonder, Edward M; Verzi, Michael P; Gao, Nan 2014. CDC42 inhibition suppresses progression of incipient intestinal tumors. Cancer research, 74 19, 5480-92Zhang, Shuangmin; Konstantinidis, Diamantis G; Yang, Jun-Qi; Mizukawa, Benjamin; Kalim, Khalid; Lang, Richard A; Kalfa, Theodosia A; Zheng, Yi; Guo, Fukun 2014. Gene targeting RhoA reveals its essential role in coordinating mitochondrial function and thymocyte development. Journal of immunology (Baltimore, Md. : 1950), 193 12, 5973-82Zheng, Yi; Geiger, Hartmut 2014. HSPCs get their motors running for asymmetric fate choice. Cell stem cell, 14 1, 1-2Zhu, Yajie; Zhou, Jitao; Xia, Hongwei; Chen, Xiangzheng; Qiu, Meng; Huang, Juan; Liu, Surui; Tang, Qiulin; Lang, Nan; Liu, Zhen; Liu, Ming; Zheng, Yi; Bi, Feng 2014. The Rho GTPase RhoE is a p53-regulated candidate tumor suppressor in cancer cells. International journal of oncology, 44 3, 896-904Guo, F; Li, J; Du, W; Zhang, S; O'Connor, M; Thomas, G; Kozma, S; Zingarelli, B; Pang, Q; Zheng, Y 2013. mTOR regulates DNA damage response through NF-?B-mediated FANCD2 pathway in hematopoietic cells. Leukemia, 27 10, 2040-2046Guo, Li; Moon, Chandra; Zheng, Yi; Ratner, Nancy 2013. Cdc42 regulates Schwann cell radial sorting and myelin sheath folding through NF2/merlin-dependent and independent signaling. Glia, 61 11, 1906-21Katayama, Kei-ichi; Imai, Fumiyasu; Campbell, Kenneth; Lang, Richard A; Zheng, Yi; Yoshida, Yutaka 2013. RhoA and Cdc42 are required in pre-migratory progenitors of the medial ganglionic eminence ventricular zone for proper cortical interneuron migration. Development (Cambridge, England), 140 15, 3139-45Melendez, Jaime; Liu, Ming; Sampson, Leesa; Akunuru, Shailaja; Han, Xiaonan; Vallance, Jefferson; Witte, David; Shroyer, Noah; Zheng, Yi 2013. Cdc42 coordinates proliferation, polarity, migration, and differentiation of small intestinal epithelial cells in mice. Gastroenterology, 145 4, 808-19Shang, Xun; Marchioni, Fillipo; Evelyn, Chris R; Sipes, Nisha; Zhou, Xuan; Seibel, William; Wortman, Matthew; Zheng, Yi 2013. Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors. Proceedings of the National Academy of Sciences of the United States of America, 110 8, 3155-60Zhou, Xuan; Florian, Maria Carolina; Arumugam, Paritha; Chen, Xiaoyi; Cancelas, Jose A; Lang, Richard; Malik, Punam; Geiger, Hartmut; Zheng, Yi 2013. RhoA GTPase controls cytokinesis and programmed necrosis of hematopoietic progenitors. The Journal of experimental medicine, 210 11, 2371-85Zhou, Xuan; Zheng, Yi 2013. Cell type-specific signaling function of RhoA GTPase: lessons from mouse gene targeting. The Journal of biological chemistry, 288 51, 36179-88Akunuru, S; James Zhai, Q; Zheng, Y 2012. Non-small cell lung cancer stem/progenitor cells are enriched in multiple distinct phenotypic subpopulations and exhibit plasticity. Cell death & disease, 3 , e352Bosco, Emily E; Kumar, Sachin; Marchioni, Filippo; Biesiada, Jacek; Kordos, Miroslaw; Szczur, Kathleen; Meller, Jarek; Seibel, William; Mizrahi, Ariel; Pick, Edgar; Filippi, Marie-Dominique; Zheng, Yi 2012. Rational design of small molecule inhibitors targeting the Rac GTPase-p67(phox) signaling axis in inflammation. Chemistry & biology, 19 2, 228-42Chang, Kyung Hee; Sanchez-Aguilera, Abel; Shen, Shuhong; Sengupta, Amitava; Madhu, Malav N; Ficker, Ashley M; Dunn, Susan K; Kuenzi, Ashley M; Arnett, Jorden L; Santho, Rebecca A; Agirre, Xabier; Perentesis, John P; Deininger, Michael W; Zheng, Yi; Bustelo, Xose R; Williams, David A; Cancelas, Jose A 2012. Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival. Blood, 120 4, 800-11Guo, Li; Moon, Chandra; Niehaus, Karen; Zheng, Yi; Ratner, Nancy 2012. Rac1 controls Schwann cell myelination through cAMP and NF2/merlin. The Journal of neuroscience : the official journal of the Society for Neuroscience, 32 48, 17251-61Katayama, Kei-ichi; Leslie, Jennifer R; Lang, Richard A; Zheng, Yi; Yoshida, Yutaka 2012. Left-right locomotor circuitry depends on RhoA-driven organization of the neuroepithelium in the developing spinal cord. The Journal of neuroscience : the official journal of the Society for Neuroscience, 32 30, 10396-407Konstantinidis, Diamantis G; Pushkaran, Suvarnamala; Johnson, James F; Cancelas, Jose A; Manganaris, Stefanos; Harris, Chad E; Williams, David A; Zheng, Yi; Kalfa, Theodosia A 2012. Signaling and cytoskeletal requirements in erythroblast enucleation. Blood, 119 25, 6118-27Kumar, Sachin; Xu, Juying; Perkins, Charles; Guo, Fukun; Snapper, Scott; Finkelman, Fred D; Zheng, Yi; Filippi, Marie-Dominique 2012. Cdc42 regulates neutrophil migration via crosstalk between WASp, CD11b, and microtubules. Blood, 120 17, 3563-74Leslie, Jennifer R; Imai, Fumiyasu; Zhou, Xuan; Lang, Richard A; Zheng, Yi; Yoshida, Yutaka 2012. RhoA is dispensable for axon guidance of sensory neurons in the mouse dorsal root ganglia. Frontiers in molecular neuroscience, 5 , 67Liu, Ming; Bi, Feng; Zhou, Xuan; Zheng, Yi 2012. Rho GTPase regulation by miRNAs and covalent modifications. Trends in cell biology, 22 7, 365-73Shang, Xun; Marchioni, Fillipo; Sipes, Nisha; Evelyn, Chris R; Jerabek-Willemsen, Moran; Duhr, Stefan; Seibel, William; Wortman, Matthew; Zheng, Yi 2012. Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases. Chemistry & biology, 19 6, 699-710Shang, Xun; Zheng, Yi 2012. Rational design of Rho GTPase-targeting inhibitors. Methods in molecular biology (Clifton, N.J.), 928 , 29-38Tan, Zongqing; Wortman, Matthew; Dillehay, Kelsey L; Seibel, William L; Evelyn, Chris R; Smith, Shanna J; Malkas, Linda H; Zheng, Yi; Lu, Shan; Dong, Zhongyun 2012. Small-molecule targeting of proliferating cell nuclear antigen chromatin association inhibits tumor cell growth. Molecular pharmacology, 81 6, 811-9Akunuru, Shailaja; Palumbo, Joseph; Zhai, Qihui James; Zheng, Yi 2011. Rac1 targeting suppresses human non-small cell lung adenocarcinoma cancer stem cell activity. PloS one, 6 2, e16951Chauhan, Bharesh K; Lou, Ming; Zheng, Yi; Lang, Richard A 2011. Balanced Rac1 and RhoA activities regulate cell shape and drive invagination morphogenesis in epithelia. Proceedings of the National Academy of Sciences of the United States of America, 108 45, 18289-94Geh, Esmond; Meng, Qinghang; Mongan, Maureen; Wang, Jingcai; Takatori, Atsushi; Zheng, Yi; Puga, Alvaro; Lang, Richard A; Xia, Ying 2011. Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) integrates developmental signals for eyelid closure. Proceedings of the National Academy of Sciences of the United States of America, 108 42, 17349-54Guo, Fukun; Zhang, Shuangmin; Tripathi, Pulak; Mattner, Jochen; Phelan, James; Sproles, Alyssa; Mo, Jun; Wills-Karp, Marsha; Grimes, H Leighton; Hildeman, David; Zheng, Yi 2011. Distinct roles of Cdc42 in thymopoiesis and effector and memory T cell differentiation. PloS one, 6 3, e18002Katayama, Kei-ichi; Melendez, Jaime; Baumann, Jessica M; Leslie, Jennifer R; Chauhan, Bharesh K; Nemkul, Niza; Lang, Richard A; Kuan, Chia-Yi; Zheng, Yi; Yoshida, Yutaka 2011. Loss of RhoA in neural progenitor cells causes the disruption of adherens junctions and hyperproliferation. Proceedings of the National Academy of Sciences of the United States of America, 108 18, 7607-12Liu, Wei; Feng, Yuxin; Shang, Xun; Zheng, Yi 2011. Rho GTPases in hematopoietic stem/progenitor cell migration. Methods in molecular biology (Clifton, N.J.), 750 , 307-19Melendez, Jaime; Grogg, Matthew; Zheng, Yi 2011. Signaling role of Cdc42 in regulating mammalian physiology. The Journal of biological chemistry, 286 4, 2375-81Melendez, Jaime; Stengel, Kristy; Zhou, Xuan; Chauhan, Bharesh K; Debidda, Marcella; Andreassen, Paul; Lang, Richard A; Zheng, Yi 2011. RhoA GTPase is dispensable for actomyosin regulation but is essential for mitosis in primary mouse embryonic fibroblasts. The Journal of biological chemistry, 286 17, 15132-7Mizukawa, Benjamin; Wei, Junping; Shrestha, Mahesh; Wunderlich, Mark; Chou, Fu-Sheng; Griesinger, Andrea; Harris, Chad E; Kumar, Ashish R; Zheng, Yi; Williams, David A; Mulloy, James C 2011. Inhibition of Rac GTPase signaling and downstream prosurvival Bcl-2 proteins as combination targeted therapy in MLL-AF9 leukemia. Blood, 118 19, 5235-45Morrison, Monique A; Morreale, Richard J; Akunuru, Shailaja; Kofron, Matthew; Zheng, Yi; Wells, Susanne I 2011. Targeting the human papillomavirus E6 and E7 oncogenes through expression of the bovine papillomavirus type 1 E2 protein stimulates cellular motility. Journal of virology, 85 20, 10487-98Plageman, Timothy F; Chauhan, Bharesh K; Yang, Christine; Jaudon, Fanny; Shang, Xun; Zheng, Yi; Lou, Ming; Debant, Anne; Hildebrand, Jeffrey D; Lang, Richard A 2011. A Trio-RhoA-Shroom3 pathway is required for apical constriction and epithelial invagination. Development (Cambridge, England), 138 23, 5177-88Shang, Xun; Cancelas, Jose A; Li, Lina; Guo, Fukun; Liu, Wei; Johnson, James F; Ficker, Ashley; Daria, Deidre; Geiger, Hartmut; Ratner, Nancy; Zheng, Yi 2011. R-Ras and Rac GTPase cross-talk regulates hematopoietic progenitor cell migration, homing, and mobilization. The Journal of biological chemistry, 286 27, 24068-78Sipes, Nisha S; Feng, Yuxin; Guo, Fukun; Lee, Hyung-Ok; Chou, Fu-Sheng; Cheng, Jonathan; Mulloy, James; Zheng, Yi 2011. Cdc42 regulates extracellular matrix remodeling in three dimensions. The Journal of biological chemistry, 286 42, 36469-77Stengel, Kristy; Zheng, Yi 2011. Cdc42 in oncogenic transformation, invasion, and tumorigenesis. Cellular signalling, 23 9, 1415-23Wang, Xiaofang; Zhang, Fan; Chen, Fanping; Liu, Dou; Zheng, Yi; Zhang, Yongliang; Dong, Chen; Su, Bing 2011. MEKK3 regulates IFN-gamma production in T cells through the Rac1/2-dependent MAPK cascades. Journal of immunology (Baltimore, Md. : 1950), 186 10, 5791-800Bosco, E E; Nakai, Y; Hennigan, R F; Ratner, N; Zheng, Y 2010. NF2-deficient cells depend on the Rac1-canonical Wnt signaling pathway to promote the loss of contact inhibition of proliferation. Oncogene, 29 17, 2540-9Bosco, Emily E; Ni, Wenjun; Wang, Lei; Guo, Fukun; Johnson, James F; Zheng, Yi 2010. Rac1 targeting suppresses p53 deficiency-mediated lymphomagenesis. Blood, 115 16, 3320-8George, Alex; Pushkaran, Suvarnamala; Li, Lina; An, Xiuli; Zheng, Yi; Mohandas, Narla; Joiner, Clinton H; Kalfa, Theodosia A 2010. Altered phosphorylation of cytoskeleton proteins in sickle red blood cells: the role of protein kinase C, Rac GTPases, and reactive oxygen species. Blood cells, molecules & diseases, 45 1, 41-5Guo, Fukun; Hildeman, David; Tripathi, Pulak; Velu, Chinavenmeni S; Grimes, H Leighton; Zheng, Yi 2010. Coordination of IL-7 receptor and T-cell receptor signaling by cell-division cycle 42 in T-cell homeostasis. Proceedings of the National Academy of Sciences of the United States of America, 107 43, 18505-10Kalfa, Theodosia A; Pushkaran, Suvarnamala; Zhang, Xiaoling; Johnson, James F; Pan, Dao; Daria, Deidre; Geiger, Hartmut; Cancelas, Jose A; Williams, David A; Zheng, Yi 2010. Rac1 and Rac2 GTPases are necessary for early erythropoietic expansion in the bone marrow but not in the spleen. Haematologica, 95 1, 27-35Mulloy, James C; Cancelas, Jose A; Filippi, Marie-Dominique; Kalfa, Theodosia A; Guo, Fukun; Zheng, Yi 2010. Rho GTPases in hematopoiesis and hemopathies. Blood, 115 5, 936-47Mulloy, James C; Cancelas, Jose A; Filippi, Marie-Dominique; Kalfa, Theodosia A; Guo, Fukun; Zheng, Yi 2010. Rho GTPases in hematopoiesis and hemopathies. Blood, 115 5, 936-47Ryan, Marnie A; Nattamai, Kalpana J; Xing, Ellen; Schleimer, David; Daria, Deidre; Sengupta, Amitava; Köhler, Anja; Liu, Wei; Gunzer, Matthias; Jansen, Michael; Ratner, Nancy; Le Cras, Timothy D; Waterstrat, Amanda; Van Zant, Gary; Cancelas, Jose A; Zheng, Yi; Geiger, Hartmut 2010. Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilization. Nature medicine, 16 10, 1141-6Bosco, E E; Mulloy, J C; Zheng, Y 2009. Rac1 GTPase: a "Rac" of all trades. Cellular and molecular life sciences : CMLS, 66 3, 370-4Chauhan, Bharesh K; Disanza, Andrea; Choi, Sue-Yeon; Faber, Sonya C; Lou, Ming; Beggs, Hilary E; Scita, Giorgio; Zheng, Yi; Lang, Richard A 2009. Cdc42- and IRSp53-dependent contractile filopodia tether presumptive lens and retina to coordinate epithelial invagination. Development (Cambridge, England), 136 21, 3657-67Chen, Lei; Melendez, Jaime; Campbell, Kenneth; Kuan, Chia-Yi; Zheng, Yi 2009. Rac1 deficiency in the forebrain results in neural progenitor reduction and microcephaly. Developmental biology, 325 1, 162-70Guo, Fukun; Velu, Chinavenmeni S; Grimes, H Leighton; Zheng, Yi 2009. Rho GTPase Cdc42 is essential for B-lymphocyte development and activation. Blood, 114 14, 2909-16Maillet, Marjorie; Lynch, Jeffrey M; Sanna, Bastiano; York, Allen J; Zheng, Yi; Molkentin, Jeffery D 2009. Cdc42 is an antihypertrophic molecular switch in the mouse heart. The Journal of clinical investigation, 119 10, 3079-88Marchioni, Filippo; Zheng, Yi 2009. Targeting rho GTPases by peptidic structures. Current pharmaceutical design, 15 21, 2481-7Milsom, Michael D; Lee, Andrew W; Zheng, Yi; Cancelas, Jose A 2009. Fanca-/- hematopoietic stem cells demonstrate a mobilization defect which can be overcome by administration of the Rac inhibitor NSC23766. Haematologica, 94 7, 1011-5Szczur, Kathleen; Zheng, Yi; Filippi, Marie-Dominique 2009. The small Rho GTPase Cdc42 regulates neutrophil polarity via CD11b integrin signaling. Blood, 114 20, 4527-37Xu, Haiming; Eleswarapu, Satyam; Geiger, Hartmut; Szczur, Kathleen; Daria, Deidre; Zheng, Yi; Settleman, Jeffrey; Srour, Edward F; Williams, David A; Filippi, Marie-Dominique 2009. Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential. Blood, 114 17, 3557-66Mulloy, James C; Wunderlich, Mark; Zheng, Yi; Wei, Junping 2008. Transforming human blood stem and progenitor cells: a new way forward in leukemia modeling. Cell cycle (Georgetown, Tex.), 7 21, 3314-9Thomas, E K; Cancelas, J A; Zheng, Y; Williams, D A 2008. Rac GTPases as key regulators of p210-BCR-ABL-dependent leukemogenesis. Leukemia, 22 5, 898-904Wei, Junping; Wunderlich, Mark; Fox, Catherine; Alvarez, Sara; Cigudosa, Juan C; Wilhelm, Jamie S; Zheng, Yi; Cancelas, Jose A; Gu, Yi; Jansen, Michael; Dimartino, Jorge F; Mulloy, James C 2008. Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia. Cancer cell, 13 6, 483-95Williams, David A; Zheng, Yi; Cancelas, Jose A 2008. Rho GTPases and regulation of hematopoietic stem cell localization. Methods in enzymology, 439 , 365-93Zhang, Xiaoling; Shang, Xun; Guo, Fukun; Murphy, Kim; Kirby, Michelle; Kelly, Patrick; Reeves, Lilith; Smith, Franklin O; Williams, David A; Zheng, Yi; Pang, Qishen 2008. Defective homing is associated with altered Cdc42 activity in cells from patients with Fanconi anemia group A. Blood, 112 5, 1683-6Akbar, H; Kim, J; Funk, K; Cancelas, J A; Shang, X; Chen, L; Johnson, J F; Williams, D A; Zheng, Y 2007. Genetic and pharmacologic evidence that Rac1 GTPase is involved in regulation of platelet secretion and aggregation. Journal of thrombosis and haemostasis : JTH, 5 8, 1747-55Chen, Lei; Liao, Guanghong; Waclaw, Ronald R; Burns, Kevin A; Linquist, Diana; Campbell, Kenneth; Zheng, Yi; Kuan, Chia-Yi 2007. Rac1 controls the formation of midline commissures and the competency of tangential migration in ventral telencephalic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience, 27 14, 3884-93Guo, Dagang; Tan, Ying-cai; Wang, Dawei; Madhusoodanan, K S; Zheng, Yi; Maack, Thomas; Zhang, J Jillian; Huang, Xin-Yun 2007. A Rac-cGMP signaling pathway. Cell, 128 2, 341-55Shang, Xun; Moon, Sun Young; Zheng, Yi 2007. p200 RhoGAP promotes cell proliferation by mediating cross-talk between Ras and Rho signaling pathways. The Journal of biological chemistry, 282 12, 8801-11Thomas, Emily K; Cancelas, Jose A; Chae, Hee-Don; Cox, Adrienne D; Keller, Patricia J; Perrotti, Danilo; Neviani, Paolo; Druker, Brian J; Setchell, Kenneth D R; Zheng, Yi; Harris, Chad E; Williams, David A 2007. Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease. Cancer cell, 12 5, 467-78Thomas, Emily K; Cancelas, Jose A; Chae, Hee-Don; Cox, Adrienne D; Keller, Patricia J; Perrotti, Danilo; Neviani, Paolo; Druker, Brian J; Setchell, Kenneth D R; Zheng, Yi; Harris, Chad E; Williams, David A 2007. Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease. Cancer cell, 12 5, 467-78Wang, Lei; Yang, Linda; Debidda, Marcella; Witte, David; Zheng, Yi 2007. Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes. Proceedings of the National Academy of Sciences of the United States of America, 104 4, 1248-53Wang, Lei; Zheng, Yi 2007. Cell type-specific functions of Rho GTPases revealed by gene targeting in mice. Trends in cell biology, 17 2, 58-64Yang, Linda; Wang, Lei; Geiger, Hartmut; Cancelas, Jose A; Mo, Jun; Zheng, Yi 2007. Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrow. Proceedings of the National Academy of Sciences of the United States of America, 104 12, 5091-6Yang, Linda; Wang, Lei; Kalfa, Theodosia A; Cancelas, Jose A; Shang, Xun; Pushkaran, Suvarnamala; Mo, Jun; Williams, David A; Zheng, Yi 2007. Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis. Blood, 110 12, 3853-61Yang, Linda; Zheng, Yi 2007. Cdc42: a signal coordinator in hematopoietic stem cell maintenance. Cell cycle (Georgetown, Tex.), 6 12, 1445-50Akbar, Huzoor; Cancelas, Jose; Williams, David A; Zheng, Jie; Zheng, Yi 2006. Rational design and applications of a Rac GTPase-specific small molecule inhibitor. Methods in enzymology, 406 , 554-65Chen, Lei; Liao, Guanghong; Yang, Linda; Campbell, Kenneth; Nakafuku, Masato; Kuan, Chia-Yi; Zheng, Yi 2006. Cdc42 deficiency causes Sonic hedgehog-independent holoprosencephaly. Proceedings of the National Academy of Sciences of the United States of America, 103 44, 16520-5Debidda, Marcella; Williams, David A; Zheng, Yi 2006. Rac1 GTPase regulates cell genomic stability and senescence. The Journal of biological chemistry, 281 50, 38519-28Ghiaur, Gabriel; Lee, Andrew; Bailey, Jeff; Cancelas, Jose A; Zheng, Yi; Williams, David A 2006. Inhibition of RhoA GTPase activity enhances hematopoietic stem and progenitor cell proliferation and engraftment. Blood, 108 6, 2087-94Gu, Y; Siefring, J E; Wang, L; Chae, H-D; Bailey, J R; Zheng, Y 2006. Oncogenic Vav1 induces Rac-dependent apoptosis via inhibition of Bcl-2 family proteins and collaborates with p53 deficiency to promote hematopoietic progenitor cell proliferation. Oncogene, 25 28, 3963-72Guo, Fukun; Debidda, Marcella; Yang, Linda; Williams, David A; Zheng, Yi 2006. Genetic deletion of Rac1 GTPase reveals its critical role in actin stress fiber formation and focal adhesion complex assembly. The Journal of biological chemistry, 281 27, 18652-9Kalfa, Theodosia A; Pushkaran, Suvarnamala; Mohandas, Narla; Hartwig, John H; Fowler, Velia M; Johnson, James F; Joiner, Clinton H; Williams, David A; Zheng, Yi 2006. Rac GTPases regulate the morphology and deformability of the erythrocyte cytoskeleton. Blood, 108 12, 3637-45Nakai, Yoko; Zheng, Yi; MacCollin, Mia; Ratner, Nancy 2006. Temporal control of Rac in Schwann cell-axon interaction is disrupted in NF2-mutant schwannoma cells. The Journal of neuroscience : the official journal of the Society for Neuroscience, 26 13, 3390-5Nakai, Yoko; Zheng, Yi; MacCollin, Mia; Ratner, Nancy 2006. Temporal control of Rac in Schwann cell-axon interaction is disrupted in NF2-mutant schwannoma cells. The Journal of neuroscience : the official journal of the Society for Neuroscience, 26 13, 3390-5Nassar, Nicolas; Cancelas, Jose; Zheng, Jie; Williams, David A; Zheng, Yi 2006. Structure-function based design of small molecule inhibitors targeting Rho family GTPases. Current topics in medicinal chemistry, 6 11, 1109-16Szczur, Kathleen; Xu, Haiming; Atkinson, Simon; Zheng, Yi; Filippi, Marie-Dominique 2006. Rho GTPase CDC42 regulates directionality and random movement via distinct MAPK pathways in neutrophils. Blood, 108 13, 4205-13Wang, Lei; Yang, Linda; Filippi, Marie-Dominique; Williams, David A; Zheng, Yi 2006. Genetic deletion of Cdc42GAP reveals a role of Cdc42 in erythropoiesis and hematopoietic stem/progenitor cell survival, adhesion, and engraftment. Blood, 107 1, 98-105Xing, Zhenlan; Ryan, Marnie A; Daria, Deidre; Nattamai, Kalpana J; Van Zant, Gary; Wang, Lei; Zheng, Yi; Geiger, Hartmut 2006. Increased hematopoietic stem cell mobilization in aged mice. Blood, 108 7, 2190-7Yang, Linda; Wang, Lei; Zheng, Yi 2006. Gene targeting of Cdc42 and Cdc42GAP affirms the critical involvement of Cdc42 in filopodia induction, directed migration, and proliferation in primary mouse embryonic fibroblasts. Molecular biology of the cell, 17 11, 4675-85Cancelas, Jose A; Lee, Andrew W; Prabhakar, Rethinasamy; Stringer, Keith F; Zheng, Yi; Williams, David A 2005. Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization. Nature medicine, 11 8, 886-91Carstanjen, Dirk; Yamauchi, Akira; Koornneef, Annemart; Zang, Heesuk; Filippi, Marie-Dominique; Harris, Chad; Towe, Jason; Atkinson, Simon; Zheng, Yi; Dinauer, Mary C; Williams, David A 2005. Rac2 regulates neutrophil chemotaxis, superoxide production, and myeloid colony formation through multiple distinct effector pathways. Journal of immunology (Baltimore, Md. : 1950), 174 8, 4613-20Debidda, Marcella; Wang, Lei; Zang, Heesuk; Poli, Valeria; Zheng, Yi 2005. A role of STAT3 in Rho GTPase-regulated cell migration and proliferation. The Journal of biological chemistry, 280 17, 17275-85Gu, Yi; Zheng, Yi; Williams, David A 2005. RhoH GTPase: a key regulator of hematopoietic cell proliferation and apoptosis? Cell cycle (Georgetown, Tex.), 4 2, 201-2Wang, Lei; Yang, Linda; Burns, Kevin; Kuan, Chia-Yi; Zheng, Yi 2005. Cdc42GAP regulates c-Jun N-terminal kinase (JNK)-mediated apoptosis and cell number during mammalian perinatal growth. Proceedings of the National Academy of Sciences of the United States of America, 102 38, 13484-9Zhang, Lin; Deng, Maoxian; Parthasarathy, Ranjani; Wang, Lei; Mongan, Maureen; Molkentin, Jeffery D; Zheng, Yi; Xia, Ying 2005. MEKK1 transduces activin signals in keratinocytes to induce actin stress fiber formation and migration. Molecular and cellular biology, 25 1, 60-5Cook-Mills, Joan M; Johnson, Jacob D; Deem, Tracy L; Ochi, Atsuo; Wang, Lei; Zheng, Yi 2004. Calcium mobilization and Rac1 activation are required for VCAM-1 (vascular cell adhesion molecule-1) stimulation of NADPH oxidase activity. The Biochemical journal, 378 Pt 2, 539-47Debreceni, Balazs; Gao, Yuan; Guo, Fukun; Zhu, Kejin; Jia, Baoqing; Zheng, Yi 2004. Mechanisms of guanine nucleotide exchange and Rac-mediated signaling revealed by a dominant negative trio mutant. The Journal of biological chemistry, 279 5, 3777-86Filippi, Marie-Dominique; Harris, Chad E; Meller, Jarek; Gu, Yi; Zheng, Yi; Williams, David A 2004. Localization of Rac2 via the C terminus and aspartic acid 150 specifies superoxide generation, actin polarity and chemotaxis in neutrophils. Nature immunology, 5 7, 744-51Gao, Yuan; Dickerson, J Bradley; Guo, Fukun; Zheng, Jie; Zheng, Yi 2004. Rational design and characterization of a Rac GTPase-specific small molecule inhibitor. Proceedings of the National Academy of Sciences of the United States of America, 101 20, 7618-23Guo, Fukun; Zheng, Yi 2004. Rho family GTPases cooperate with p53 deletion to promote primary mouse embryonic fibroblast cell invasion. Oncogene, 23 33, 5577-85Guo, Fukun; Zheng, Yi 2004. Involvement of Rho family GTPases in p19Arf- and p53-mediated proliferation of primary mouse embryonic fibroblasts. Molecular and cellular biology, 24 3, 1426-38Wang, Lei; Zhu, Kejin; Zheng, Yi 2004. Oncogenic Dbl, Cdc42, and p21-activated kinase form a ternary signaling intermediate through the minimum interactive domains. Biochemistry, 43 46, 14584-93Guo, Fukun; Gao, Yuan; Wang, Lei; Zheng, Yi 2003. p19Arf-p53 tumor suppressor pathway regulates cell motility by suppression of phosphoinositide 3-kinase and Rac1 GTPase activities. The Journal of biological chemistry, 278 16, 14414-9Moon, Sun Young; Zang, Heesuk; Zheng, Yi 2003. Characterization of a brain-specific Rho GTPase-activating protein, p200RhoGAP. The Journal of biological chemistry, 278 6, 4151-9Moon, Sun Young; Zheng, Yi 2003. Rho GTPase-activating proteins in cell regulation. Trends in cell biology, 13 1, 13-22Wang, Lei; Yang, Linda; Luo, Yongneng; Zheng, Yi 2003. A novel strategy for specifically down-regulating individual Rho GTPase activity in tumor cells. The Journal of biological chemistry, 278 45, 44617-25Zheng, Yi; Quilliam, Lawrence A 2003. Activation of the Ras superfamily of small GTPases. Workshop on exchange factors. EMBO reports, 4 5, 463-8Akbar, Huzoor; Duan, Xin; Saleem, Saima; Davis, Ashley K; Zheng, Yi . RhoA and Rac1 GTPases Differentially Regulate Agonist-Receptor Mediated Reactive Oxygen Species Generation in Platelets. PloS one, 11 9, e0163227
Zhang, Dongsheng; Tang, Wenjuan; Niu, Haitao; Tse, William; Ruan, Hai-Bin; Dolznig, Helmut; Knösel, Thomas; Karl-Heinz, Friedrich; Themanns, Madeleine; Wang, Jiang; Song, Mingquan; Denson, Lee; Kenner, Lukas; Moriggl, Richard; Zheng, Yi; Han, Xiaonan 2024. Monogenic deficiency in murine intestinal Cdc42 leads to mucosal inflammation that induces crypt dysplasia. Genes & diseases, 11 1, 413-429Dandamudi, Akhila; Akbar, Huzoor; Cancelas, Jose; Zheng, Yi 2023. Rho GTPase Signaling in Platelet Regulation and Implication for Antiplatelet Therapies. International journal of molecular sciences, 24 3, Dandamudi, Akhila; Seibel, William; Tourdot, Benjamin; Cancelas, Jose A; Akbar, Huzoor; Zheng, Yi 2023. Structure-Activity Relationship Analysis of Rhosin, a RhoA GTPase Inhibitor, Reveals a New Class of Antiplatelet Agents. International journal of molecular sciences, 24 4, Fan, Cuiqing; Wunderlich, Mark; Cai, Xiongwei; Yan, Zijun; Zhang, Feng; Davis, Ashley Kuenzi; Xu, Lingli; Guo, Fukun; Lu, Q Richard; Azam, Mohammad; Tian, Weidong; Zheng, Yi 2023. Kinase-independent role of mTOR and on-/off-target effects of an mTOR kinase inhibitor. Leukemia, 37 10, 2073-2081Katayama, Kei-Ichi; Zheng, Yi; Inoue, Norimitsu 2023. Rac is required for the survival of cortical neurons. Experimental neurology, 361 , 114316Li, Yuehuan; Martin, Taylor Elijah; Hancock, Jonathan Matthew; Li, Rong; Viswanathan, Suvitha; Lydon, John P; Zheng, Yi; Ye, Xiaoqin 2023. Visualization of preimplantation uterine fluid absorption in mice using Alexa Fluor™ 488 Hydrazide†. Biology of reproduction, 108 2, 204-217Modur, Vishnu; Muhammad, Belal; Yang, Jun-Qi; Zheng, Yi; Komurov, Kakajan; Guo, Fukun 2023. Mechanism of inert inflammation in an immune checkpoint blockade-resistant tumor subtype bearing transcription elongation defects. Cell reports, 42 4, 112364Wang, Chen; Tu, Zhaowei; Cai, Xiongwei; Wang, Weinan; Davis, Ashely K; Nattamai, Kalpana; Paranjpe, Aditi; Dexheimer, Philip; Wu, Jianqiang; Huang, Frank Lei; Geiger, Hartmut; Huang, Gang; Zheng, Yi 2023. A critical role of RUNX1 in governing megakaryocyte-primed hematopoietic stem cell differentiation. Blood advances, 7 11, 2590-2605Zhang, Cuiping; Cui, Xiaojing; Liu, Yi; Wang, Fang; Signer, Robert; Nattamai, Kapana; Zhou, Daohong; Zheng, Yi; Geiger, Hartmut; Wan, Fengyi; Liang, Ying 2023. Latexin deletion protects against radiation-induced hematopoietic damages via selective activation of Bcl-2 prosurvival pathway. Haematologica, 108 12, 3464-3470Akwii, Racheal Grace; Sajib, Md Sanaullah; Zahra, Fatema Tuz; Tullar, Paul; Zabet-Moghaddam, Masoud; Zheng, Yi; Silvio Gutkind, J; Doci, Colleen L; Mikelis, Constantinos M 2022. Angiopoietin-2-induced lymphatic endothelial cell migration drives lymphangiogenesis via the β1 integrin-RhoA-formin axis. Angiogenesis, 25 3, 373-396Amoah, Amanda; Keller, Anja; Emini, Ramiz; Hoenicka, Markus; Liebold, Andreas; Vollmer, Angelika; Eiwen, Karina; Soller, Karin; Sakk, Vadim; Zheng, Yi; Florian, Maria Carolina; Geiger, Hartmut 2022. Aging of human hematopoietic stem cells is linked to changes in Cdc42 activity. Haematologica, 107 2, 393-402Hegde, Shailaja; Gasilina, Anjelika; Wunderlich, Mark; Lin, Yuan; Buchholzer, Marcel; Krumbach, Oliver H F; Akbarzadeh, Mohammad; Ahmadian, Mohammad Reza; Seibel, William; Zheng, Yi; Perentesis, John P; Mizukawa, Benjamin E; Vinnedge, Lisa Privette; Cancelas, José A; Nassar, Nicolas N 2022. Inhibition of the RacGEF VAV3 by the small molecule IODVA1 impedes RAC signaling and overcomes resistance to tyrosine kinase inhibition in acute lymphoblastic leukemia. Leukemia, 36 3, 637-647Hegde, Shailaja; Zheng, Yi; Cancelas, Jose A 2022. Novel blood derived hemostatic agents for bleeding therapy and prophylaxis. Current opinion in hematology, 29 6, 281-289Kalim, Khalid W; Yang, Jun-Qi; Wunderlich, Mark; Modur, Vishnu; Nguyen, Phuong; Li, Yuan; Wen, Ting; Davis, Ashley Kuenzi; Verma, Ravinder; Lu, Qing Richard; Jegga, Anil G; Zheng, Yi; Guo, Fukun 2022. Targeting of Cdc42 GTPase in regulatory T cells unleashes antitumor T-cell immunity. Journal for immunotherapy of cancer, 10 11, Katayama, Kei-Ichi; Zheng, Yi; Inoue, Norimitsu 2022. Rac-deficient cerebellar granule neurons die before they migrate to the internal granule layer. Scientific reports, 12 1, 14848Kim, Kee-Beom; Kim, Dong-Wook; Kim, Youngchul; Tang, Jun; Kirk, Nicole; Gan, Yongyu; Kim, Bongjun; Fang, Bingliang; Park, Jae-Ll; Zheng, Yi; Park, Kwon-Sik 2022. WNT5A-RHOA Signaling Is a Driver of Tumorigenesis and Represents a Therapeutically Actionable Vulnerability in Small Cell Lung Cancer. Cancer research, 82 22, 4219-4233Kim, Young-Woong; Zara, Greta; Kang, HyunJun; Branciamore, Sergio; O'Meally, Denis; Feng, Yuxin; Kuan, Chia-Yi; Luo, Yingjun; Nelson, Michael S; Brummer, Alex B; Rockne, Russell; Chen, Zhen Bouman; Zheng, Yi; Cardoso, Angelo A; Carlesso, Nadia 2022. Integration of single-cell transcriptomes and biological function reveals distinct behavioral patterns in bone marrow endothelium. Nature communications, 13 1, 7235Montserrat-Vazquez, Sara; Ali, Noelle J; Matteini, Francesca; Lozano, Javier; Zhaowei, Tu; Mejia-Ramirez, Eva; Marka, Gina; Vollmer, Angelika; Soller, Karin; Sacma, Mehmet; Sakk, Vadim; Mularoni, Loris; Mallm, Jan Philipp; Plass, Mireya; Zheng, Yi; Geiger, Hartmut; Florian, M Carolina 2022. Transplanting rejuvenated blood stem cells extends lifespan of aged immunocompromised mice. NPJ Regenerative medicine, 7 1, 78Nalapareddy, Kodandaramireddy; Zheng, Yi; Geiger, Hartmut 2022. Aging of intestinal stem cells. Stem cell reports, 17 4, 734-740Romano, Laurel; Seu, Katie G; Papoin, Julien; Muench, David E; Konstantinidis, Diamantis; Olsson, André; Schlum, Katrina; Chetal, Kashish; Chasis, Joel Anne; Mohandas, Narla; Barnes, Betsy J; Zheng, Yi; Grimes, H Leighton; Salomonis, Nathan; Blanc, Lionel; Kalfa, Theodosia A 2022. Erythroblastic islands foster granulopoiesis in parallel to terminal erythropoiesis. Blood, 140 14, 1621-1634Tu, Zhaowei; Fan, Cuiqing; Davis, Ashely K; Hu, Mengwen; Wang, Chen; Dandamudi, Akhila; Seu, Katie G; Kalfa, Theodosia A; Lu, Q Richard; Zheng, Yi 2022. Autism-associated chromatin remodeler CHD8 regulates erythroblast cytokinesis and fine-tunes the balance of Rho GTPase signaling. Cell reports, 40 2, 111072Tu, Zhaowei; Zheng, Yi 2022. Role of ATP-dependent chromatin remodelers in hematopoietic stem and progenitor cell maintenance. Current opinion in hematology, 29 4, 174-180Zhang, Zheng; Zhang, Feng; Davis, Ashley Kuenzi; Xin, Mei; Walz, Gerd; Tian, Weidong; Zheng, Yi 2022. CDC42 controlled apical-basal polarity regulates intestinal stem cell to transit amplifying cell fate transition via YAP-EGF-mTOR signaling. Cell reports, 38 2, 110009Chlon, Timothy M; Stepanchick, Emily; Hershberger, Courtney E; Daniels, Noah J; Hueneman, Kathleen M; Kuenzi Davis, Ashley; Choi, Kwangmin; Zheng, Yi; Gurnari, Carmelo; Haferlach, Torsten; Padgett, Richard A; Maciejewski, Jaroslaw P; Starczynowski, Daniel T 2021. Germline DDX41 mutations cause ineffective hematopoiesis and myelodysplasia. Cell stem cell, 28 11, 1966-1981.e6Duan, Xin; Perveen, Rehana; Dandamudi, Akhila; Adili, Reheman; Johnson, James; Funk, Kevin; Berryman, Mark; Davis, Ashley Kuenzi; Holinstat, Michael; Zheng, Yi; Akbar, Huzoor 2021. Pharmacologic targeting of Cdc42 GTPase by a small molecule Cdc42 activity-specific inhibitor prevents platelet activation and thrombosis. Scientific reports, 11 1, 13170Fan, Cuiqing; Zhao, Chuntao; Zhang, Feng; Kesarwani, Meenu; Tu, Zhaowei; Cai, Xiongwei; Davis, Ashley Kuenzi; Xu, Lingli; Hochstetler, Cindy L; Chen, Xiaoyi; Guo, Fukun; Huang, Gang; Azam, Mohammad; Tian, Weidong; Lu, Q Richard; Zheng, Yi 2021. Adaptive responses to mTOR gene targeting in hematopoietic stem cells reveal a proliferative mechanism evasive to mTOR inhibition. Proceedings of the National Academy of Sciences of the United States of America, 118 1, Fan, Yuping; Teng, Yan; Loison, Fabien; Pang, Aiming; Kasorn, Anongnard; Shao, Xinqi; Zhang, Cunling; Ren, Qian; Yu, Hongbo; Zheng, Yi; Cancelas, Jose A; Manis, John; Chai, Li; Park, Shin-Young; Zhao, Li; Xu, Yuanfu; Feng, Sizhou; Silberstein, Leslie E; Ma, Fengxia; Luo, Hongbo R 2021. Targeting multiple cell death pathways extends the shelf life and preserves the function of human and mouse neutrophils for transfusion. Science translational medicine, 13 604, Guidi, Novella; Marka, Gina; Sakk, Vadim; Zheng, Yi; Florian, Maria Carolina; Geiger, Hartmut 2021. An aged bone marrow niche restrains rejuvenated hematopoietic stem cells. Stem cells (Dayton, Ohio), 39 8, 1101-1106Hegde, Shailaja; Wellendorf, Ashley M; Zheng, Yi; Cancelas, Jose A 2021. Antioxidant prevents clearance of hemostatically competent platelets after long-term cold storage. Transfusion, 61 2, 557-567Kalim, Khalid W; Yang, Jun-Qi; Modur, Vishnu; Nguyen, Phuong; Li, Yuan; Zheng, Yi; Guo, Fukun 2021. Graded RhoA GTPase Expression in Treg Cells Distinguishes Tumor Immunity From Autoimmunity. Frontiers in immunology, 12 , 726393Kandi, Ravinder; Senger, Katharina; Grigoryan, Ani; Soller, Karin; Sakk, Vadim; Schuster, Tanja; Eiwen, Karina; Menon, Manoj B; Gaestel, Matthias; Zheng, Yi; Florian, Maria Carolina; Geiger, Hartmut 2021. Cdc42-Borg4-Septin7 axis regulates HSC polarity and function. EMBO reports, 22 12, e52931Lin, Yuan; Lu, Shaoyong; Zhang, Jian; Zheng, Yi 2021. Structure of an inactive conformation of GTP-bound RhoA GTPase. Structure (London, England : 1993), 29 6, 553-563.e5Lin, Yuan; Watanabe-Chailland, Miki; Zheng, Yi 2021. Protocol for structural and biochemical analyses of RhoA GTPase. STAR protocols, 2 2, 100541Nakamura, Yuka; Ueno, Masaki; Niehaus, Jesse K; Lang, Richard A; Zheng, Yi; Yoshida, Yutaka 2021. Modulation of Both Intrinsic and Extrinsic Factors Additively Promotes Rewiring of Corticospinal Circuits after Spinal Cord Injury. The Journal of neuroscience : the official journal of the Society for Neuroscience, 41 50, 10247-10260Nalapareddy, Kodandaramireddy; Hassan, Aishlin; Sampson, Leesa L; Zheng, Yi; Geiger, Hartmut 2021. Suppression of elevated Cdc42 activity promotes the regenerative potential of aged intestinal stem cells. iScience, 24 4, 102362Sertorio, Mathieu; Nowrouzi, Ali; Akbarpour, Mahdi; Chetal, Kashish; Salomonis, Nathan; Brons, Stephan; Mascia, Anthony; Ionascu, Dan; McCauley, Shelby; Kupneski, Taylor; Köthe, Andreas; Debus, Jürgen; Perentesis, John P; Abdollahi, Amir; Zheng, Yi; Wells, Susanne I 2021. Differential transcriptome response to proton versus X-ray radiation reveals novel candidate targets for combinatorial PT therapy in lymphoma. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 155 , 293-303Sheng, Yue; Ma, Rui; Yu, Chunjie; Wu, Qiong; Zhang, Steven; Paulsen, Kimberly; Zhang, Jiwang; Ni, Hongyu; Huang, Yong; Zheng, Yi; Qian, Zhijian 2021. Role of c-Myc haploinsufficiency in the maintenance of HSCs in mice. Blood, 137 5, 610-623Tu, Zhaowei; Wang, Chen; Davis, Ashley K; Hu, Mengwen; Zhao, Chuntao; Xin, Mei; Lu, Q Richard; Zheng, Yi 2021. The chromatin remodeler CHD8 governs hematopoietic stem/progenitor survival by regulating ATM-mediated P53 protein stability. Blood, 138 3, 221-233Zhang, Bin; Nguyen, Le Xuan Truong; Zhao, Dandan; Frankhouser, David E; Wang, Huafeng; Hoang, Dinh Hoa; Qiao, Junjing; Abundis, Christina; Brehove, Matthew; Su, Yu-Lin; Feng, Yuxin; Stein, Anthony; Ghoda, Lucy; Dorrance, Adrianne; Perrotti, Danilo; Chen, Zhen; Han, Anjia; Pichiorri, Flavia; Jin, Jie; Jovanovic-Talisman, Tijana; Caligiuri, Michael A; Kuo, Calvin J; Yoshimura, Akihiko; Li, Ling; Rockne, Russell C; Kortylewski, Marcin; Zheng, Yi; Carlesso, Nadia; Kuo, Ya-Huei; Marcucci, Guido 2021. Treatment-induced arteriolar revascularization and miR-126 enhancement in bone marrow niche protect leukemic stem cells in AML. Journal of hematology & oncology, 14 1, 122Zhang, Zheng; Liu, Ming; Zheng, Yi 2021. Role of Rho GTPases in stem cell regulation. Biochemical Society transactions, 49 6, 2941-2955Althoff, Mark; Nayak, Ramesh; Hegde, Shailaja; Wellendorf, Ashley; Bohan, Breanna; Filippi, Marie-Dominique; Xin, Mei; Lu, Richard; Geiger, Hartmut; Zheng, Yi; Diaz-Meco, Maria T; Moscat, Jorge; Cancelas, Jose A 2020. Yap1-Scribble polarization is required for hematopoietic stem cell division and fate. Blood, , Florian, Maria Carolina; Leins, Hanna; Gobs, Michael; Han, Yang; Marka, Gina; Soller, Karin; Vollmer, Angelika; Sakk, Vadim; Nattamai, Kalpana J; Rayes, Ahmad; Zhao, Xueheng; Setchell, Kenneth; Mulaw, Medhanie; Wagner, Wolfgang; Zheng, Yi; Geiger, Hartmut 2020. Inhibition of Cdc42 activity extends lifespan and decreases circulating inflammatory cytokines in aged female C57BL/6 mice. Aging cell, , e13208Muto, Tomoya; Walker, Callum S; Choi, Kwangmin; Hueneman, Kathleen; Smith, Molly A; Gul, Zartash; Garcia-Manero, Guillermo; Ma, Averil; Zheng, Yi; Starczynowski, Daniel T 2020. Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs. Nature immunology, 21 5, 535-545Papaioannou, Dimitrios; Petri, Andreas; Dovey, Oliver M; Terreri, Sara; Wang, Eric; Collins, Frances A; Woodward, Lauren A; Walker, Allison E; Nicolet, Deedra; Pepe, Felice; Kumchala, Prasanthi; Bill, Marius; Walker, Christopher J; Karunasiri, Malith; Mrózek, Krzysztof; Gardner, Miranda L; Camilotto, Virginia; Zitzer, Nina; Cooper, Jonathan L; Cai, Xiongwei; Rong-Mullins, Xiaoqing; Kohlschmidt, Jessica; Archer, Kellie J; Freitas, Michael A; Zheng, Yi; Lee, Robert J; Aifantis, Iannis; Vassiliou, George; Singh, Guramrit; Kauppinen, Sakari; Bloomfield, Clara D; Dorrance, Adrienne M; Garzon, Ramiro 2020. Author Correction: The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia. Nature communications, 11 1, 3878Papaioannou, Dimitrios; Petri, Andreas; Dovey, Oliver M; Terreri, Sara; Wang, Eric; Collins, Frances A; Woodward, Lauren A; Walker, Allison E; Nicolet, Deedra; Pepe, Felice; Kumchala, Prasanthi; Bill, Marius; Walker, Christopher J; Karunasiri, Malith; Mrózek, Krzysztof; Gardner, Miranda L; Camilotto, Virginia; Zitzer, Nina; Cooper, Jonathan L; Cai, Xiongwei; Rong-Mullins, Xiaoqing; Kohlschmidt, Jessica; Archer, Kellie J; Freitas, Michael A; Zheng, Yi; Lee, Robert J; Aifantis, Iannis; Vassiliou, George; Singh, Guramrit; Kauppinen, Sakari; Bloomfield, Clara D; Dorrance, Adrienne M; Garzon, Ramiro 2020. Publisher Correction: The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia. Nature communications, 11 1, 204Sheng, Yue; Ma, Rui; Yu, Chunjie; Wu, Qiong; Zhang, Steven; Paulsen, Kimberly; Zhang, Jiwang; Ni, Hongyu; Huang, Yong; Zheng, Yi; Qian, Zhijian 2020. Role of c-Myc haploinsufficiency in the maintenance of HSCs. Blood, , Sheng, Yue; Ma, Rui; Yu, Chunjie; Wu, Qiong; Zhang, Steven; Paulsen, Kimberly; Zhang, Jiwang; Ni, Hongyu; Huang, Yong; Zheng, Yi; Qian, Zhijian 2020. Role of c-Myc haploinsufficiency in the maintenance of HSCs. Blood, , Hochstetler, Cindy L; Feng, Yuxin; Sacma, Mehmet; Davis, Ashley K; Rao, Mahil; Kuan, Chia-Yi; You, Li-Ru; Geiger, Hartmut; Zheng, Yi 2019. KRasG12D expression in the bone marrow vascular niche affects hematopoiesis with inflammatory signals. Experimental hematology, , Nayak, R C; Hegde, S; Althoff, M J; Wellendorf, A M; Mohmoud, F; Perentesis, J; Reina-Campos, M; Reynaud, D; Zheng, Y; Diaz-Meco, M T; Moscat, J; Cancelas, J A 2019. The signaling axis atypical protein kinase C ?/?-Satb2 mediates leukemic transformation of B-cell progenitors. Nature communications, 10 1, 46Nguyen, Phuong; Chakrabarti, Jayati; Li, Yuan; Kalim, Khalid W; Zhang, Mengnan; Zhang, Lin; Zheng, Yi; Guo, Fukun 2019. Rational Targeting of Cdc42 Overcomes Drug Resistance of Multiple Myeloma. Frontiers in oncology, 9 , 958Papaioannou, Dimitrios; Petri, Andreas; Dovey, Oliver M; Terreri, Sara; Wang, Eric; Collins, Frances A; Woodward, Lauren A; Walker, Allison E; Nicolet, Deedra; Pepe, Felice; Kumchala, Prasanthi; Bill, Marius; Walker, Christopher J; Karunasiri, Malith; Mrózek, Krzysztof; Gardner, Miranda L; Camilotto, Virginia; Zitzer, Nina; Cooper, Jonathan L; Cai, Xiongwei; Rong-Mullins, Xiaoqing; Kohlschmidt, Jessica; Archer, Kellie J; Freitas, Michael A; Zheng, Yi; Lee, Robert J; Aifantis, Iannis; Vassiliou, George; Singh, Guramrit; Kauppinen, Sakari; Bloomfield, Clara D; Dorrance, Adrienne M; Garzon, Ramiro 2019. The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia. Nature communications, 10 1, 5351Xie, Yangyang; Gao, Li; Xu, Chunhui; Chu, Liming; Gao, Lei; Wu, Ruichi; Liu, Yu; Liu, Ting; Sun, Xiao-Jian; Ren, Ruibao; Tang, Jingyan; Zheng, Yi; Zhou, Yong; Shen, Shuhong 2019. ARHGEF12 regulates erythropoiesis and is involved in erythroid regeneration after chemotherapy in acute lymphoblastic leukemia patients. Haematologica, , Yang, Jun-Qi; Kalim, Khalid W; Li, Yuan; Duan, Xin; Nguyen, Phuong; Khurana Hershey, Gurjit K; Kroner, John; Ruff, Brandy; Zhang, Li; Salomonis, Nathan; Rochman, Mark; Wen, Ting; Zheng, Yi; Guo, Fukun 2019. Rational targeting Cdc42 restrains Th2 cell differentiation and prevents allergic airway inflammation. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 49 1, 92-107Yang, Jun-Qi; Kalim, Khalid W; Li, Yuan; Zheng, Yi; Guo, Fukun 2019. Ablation of RhoA impairs Th17 cell differentiation and alleviates house dust mite-triggered allergic airway inflammation. Journal of leukocyte biology, , Zahra, Fatema Tuz; Sajib, Md Sanaullah; Ichiyama, Yusuke; Akwii, Racheal Grace; Tullar, Paul E; Cobos, Christopher; Minchew, Shelby A; Doçi, Colleen L; Zheng, Yi; Kubota, Yoshiaki; Gutkind, J Silvio; Mikelis, Constantinos M 2019. Endothelial RhoA GTPase is essential for in vitro endothelial functions but dispensable for physiological in vivo angiogenesis. Scientific reports, 9 1, 11666Zhang, Cuiping; Fondufe-Mittendorf, Yvonne N; Wang, Chi; Chen, Jin; Cheng, Qiang; Zhou, Daohong; Zheng, Yi; Geiger, Hartmut; Liang, Ying 2019. Latexin regulation by HMGB2 is required for hematopoietic stem cell maintenance. Haematologica, , Zhou, Wei; Yang, Yingying; Mei, Congjin; Dong, Panpan; Mu, Shasha; Wu, Hongchu; Zhou, Yonghua; Zheng, Yi; Guo, Fukun; Yang, Jun-Qi 2019. Inhibition of Rho-Kinase Downregulates Th17 Cells and Ameliorates Hepatic Fibrosis by Schistosoma japonicum Infection. Cells, 8 10, Akbar, H; Duan, X; Piatt, R; Saleem, S; Davis, A K; Tandon, N N; Bergmeier, W; Zheng, Y 2018. Small molecule targeting the Rac1-NOX2 interaction prevents collagen-related peptide and thrombin-induced reactive oxygen species generation and platelet activation. Journal of thrombosis and haemostasis : JTH, 16 10, 2083-2096Cai, Xiongwei; Zheng, Yi; Speck, Nancy A 2018. A Western Blotting Protocol for Small Numbers of Hematopoietic Stem Cells. Journal of visualized experiments : JoVE, 138, Cai, Xiongwei; Zhou, Xuan; Zheng, Yi 2018. In Vivo Rescue Assay of RhoA-Deficient Hematopoietic Stem and Progenitor Cells. Methods in molecular biology (Clifton, N.J.), 1821 , 247-256Chadwick, Michelle L; Lane, Adam; Thomas, Dana; Smith, Amanda R; White, Angela R; Davidson, Dominique; Feng, Yuxin; Boscolo, Elisa; Zheng, Yi; Adams, Denise M; Gupta, Anita; Veillette, André; Chow, Lionel M L 2018. Combined mTOR and MEK inhibition is an effective therapy in a novel mouse model for angiosarcoma. Oncotarget, 9 37, 24750-24765Du, Wei; Liu, Wei; Mizukawa, Benjamin; Shang, Xun; Sipple, Jared; Wunderlich, Mark; Geiger, Hartmut; Davies, Stella; Mulloy, James; Pang, Qishen; Zheng, Yi 2018. A non-myeloablative conditioning approach for long-term engraftment of human and mouse hematopoietic stem cells. Leukemia, 32 9, 2041-2046Fang, Jing; Muto, Tomoya; Kleppe, Maria; Bolanos, Lyndsey C; Hueneman, Kathleen M; Walker, Callum S; Sampson, Leesa; Wellendorf, Ashley M; Chetal, Kashish; Choi, Kwangmin; Salomonis, Nathan; Choi, Yongwon; Zheng, Yi; Cancelas, Jose A; Levine, Ross L; Starczynowski, Daniel T 2018. TRAF6 Mediates Basal Activation of NF-?B Necessary for Hematopoietic Stem Cell Homeostasis. Cell reports, 22 5, 1250-1262Florian, M Carolina; Klose, Markus; Sacma, Mehmet; Jablanovic, Jelena; Knudson, Luke; Nattamai, Kalpana J; Marka, Gina; Vollmer, Angelika; Soller, Karin; Sakk, Vadim; Cabezas-Wallscheid, Nina; Zheng, Yi; Mulaw, Medhanie A; Glauche, Ingmar; Geiger, Hartmut 2018. Aging alters the epigenetic asymmetry of HSC division. PLoS biology, 16 9, e2003389Grigoryan, Ani; Guidi, Novella; Senger, Katharina; Liehr, Thomas; Soller, Karin; Marka, Gina; Vollmer, Angelika; Markaki, Yolanda; Leonhardt, Heinrich; Buske, Christian; Lipka, Daniel B; Plass, Christoph; Zheng, Yi; Mulaw, Medhanie A; Geiger, Hartmut; Florian, Maria Carolina 2018. LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells. Genome biology, 19 1, 189Hayashi, Yoshihiro; Zhang, Yue; Yokota, Asumi; Yan, Xiaomei; Liu, Jinqin; Choi, Kwangmin; Li, Bing; Sashida, Goro; Peng, Yanyan; Xu, Zefeng; Huang, Rui; Zhang, Lulu; Freudiger, George M; Wang, Jingya; Dong, Yunzhu; Zhou, Yile; Wang, Jieyu; Wu, Lingyun; Bu, Jiachen; Chen, Aili; Zhao, Xinghui; Sun, Xiujuan; Chetal, Kashish; Olsson, Andre; Watanabe, Miki; Romick-Rosendale, Lindsey E; Harada, Hironori; Shih, Lee-Yung; Tse, William; Bridges, James P; Caligiuri, Michael A; Huang, Taosheng; Zheng, Yi; Witte, David P; Wang, Qian-Fei; Qu, Cheng-Kui; Salomonis, Nathan; Grimes, H Leighton; Nimer, Stephen D; Xiao, Zhijian; Huang, Gang 2018. Pathobiological Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes. Cancer discovery, 8 11, 1438-1457Hegde, Shailaja; Akbar, Huzoor; Zheng, Yi; Cancelas, Jose A 2018. Towards increasing shelf life and haemostatic potency of stored platelet concentrates. Current opinion in hematology, 25 6, 500-508Jiang, Xi; Hu, Chao; Ferchen, Kyle; Nie, Ji; Cui, Xiaolong; Chen, Chih-Hong; Cheng, Liting; Zuo, Zhixiang; Seibel, William; He, Chunjiang; Tang, Yixuan; Skibbe, Jennifer R; Wunderlich, Mark; Reinhold, William C; Dong, Lei; Shen, Chao; Arnovitz, Stephen; Ulrich, Bryan; Lu, Jiuwei; Weng, Hengyou; Su, Rui; Huang, Huilin; Wang, Yungui; Li, Chenying; Qin, Xi; Mulloy, James C; Zheng, Yi; Diao, Jiajie; Jin, Jie; Li, Chong; Liu, Paul P; He, Chuan; Chen, Yuan; Chen, Jianjun 2018. Author Correction: Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia. Nature communications, 9 1, 670Kalim, Khalid W; Yang, Jun-Qi; Li, Yuan; Meng, Yan; Zheng, Yi; Guo, Fukun 2018. Reciprocal Regulation of Glycolysis-Driven Th17 Pathogenicity and Regulatory T Cell Stability by Cdc42. Journal of immunology (Baltimore, Md. : 1950), 200 7, 2313-2326Liu, Wei; Du, Wei; Shang, Xun; Wang, Lei; Evelyn, Chris; Florian, Maria Carolina; A Ryan, Marnie; Rayes, Ahmad; Zhao, Xueheng; Setchell, Kenneth; Meller, Jarek; Guo, Fukun; Nassar, Nicolas; Geiger, Hartmut; Pang, Qishen; Zheng, Yi 2018. Rational identification of a Cdc42 inhibitor presents a new regimen for long-term hematopoietic stem cell mobilization. Leukemia, , Lv, Jiawen; Zeng, Junchao; Guo, Fukun; Li, Yiran; Xu, Mengying; Cheng, Yuanxiong; Zhang, Lin; Cai, Shaoxi; Chen, Yinghua; Zheng, Yi; Hu, Guodong 2018. Endothelial Cdc42 deficiency impairs endothelial regeneration and vascular repair after inflammatory vascular injury. Respiratory research, 19 1, 27Maliken, Bryan D; Kanisicak, Onur; Karch, Jason; Khalil, Hadi; Fu, Xing; Boyer, Justin G; Prasad, Vikram; Zheng, Yi; Molkentin, Jeffery D 2018. Gata4-Dependent Differentiation of c-Kit+ Derived Endothelial Cells Underlies Artefactual Cardiomyocyte Regeneration in the Heart. Circulation, , Mizukawa, Benjamin; O'Brien, Eric; Mulloy, James C; Zheng, Yi 2018. Cell Polarity and Division Symmetry Analyses in Transformed Blood Cells. Methods in molecular biology (Clifton, N.J.), 1821 , 257-266Sertorio, Mathieu; Perentesis, John P; Vatner, Ralph E; Mascia, Anthony E; Zheng, Yi; Wells, Susanne I 2018. Cancer Cell Metabolism: Implications for X-ray and Particle Radiation Therapy. International journal of particle therapy, 5 1, 40-48Wu, Lai Man Natalie; Deng, Yaqi; Wang, Jincheng; Zhao, Chuntao; Wang, Jiajia; Rao, Rohit; Xu, Lingli; Zhou, Wenhao; Choi, Kwangmin; Rizvi, Tilat A; Remke, Marc; Rubin, Joshua B; Johnson, Randy L; Carroll, Thomas J; Stemmer-Rachamimov, Anat O; Wu, Jianqiang; Zheng, Yi; Xin, Mei; Ratner, Nancy; Lu, Q Richard 2018. Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis. Cancer cell, 33 2, 292-308.e7Yang, Yingying; Dong, Panpan; Zhao, Jing; Zhou, Wei; Zhou, Yonghua; Xu, Yongliang; Mei, Congjin; Guo, Fukun; Zheng, Yi; Yang, Jun-Qi 2018. PKC?/? regulates Th17 differentiation and house dust mite-induced allergic airway inflammation. Biochimica et biophysica acta, 1864 3, 934-941Chen, Xiaoyi; Clark, Jason; Wunderlich, Mark; Fan, Cuiqing; Davis, Ashley; Chen, Song; Guan, Jun-Lin; Mulloy, James C; Kumar, Ashish; Zheng, Yi 2017. Autophagy is dispensable for Kmt2a/Mll-Mllt3/Af9 AML maintenance and anti-leukemic effect of chloroquine. Autophagy, 13 5, 955-966El Zowalaty, Ahmed E; Li, Rong; Zheng, Yi; Lydon, John P; DeMayo, Francesco J; Ye, Xiaoqin 2017. Deletion of RhoA in Progesterone Receptor-Expressing Cells Leads to Luteal Insufficiency and Infertility in Female Mice. Endocrinology, 158 7, 2168-2178Fang, Jing; Bolanos, Lyndsey C; Choi, Kwangmin; Liu, Xiaona; Christie, Susanne; Akunuru, Shailaja; Kumar, Rupali; Wang, Dehua; Chen, Xiaoting; Greis, Kenneth D; Stoilov, Peter; Filippi, Marie-Dominique; Maciejewski, Jaroslaw P; Garcia-Manero, Guillermo; Weirauch, Matthew T; Salomonis, Nathan; Geiger, Hartmut; Zheng, Yi; Starczynowski, Daniel T 2017. Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia. Nature immunology, 18 2, 236-245Guo, Fukun; Zheng, Yi 2017. Vav1: Friend and Foe of Cancer. Trends in cell biology, 27 12, 879-880Hato, Takashi; Winfree, Seth; Day, Richard; Sandoval, Ruben M; Molitoris, Bruce A; Yoder, Mervin C; Wiggins, Roger C; Zheng, Yi; Dunn, Kenneth W; Dagher, Pierre C 2017. Two-Photon Intravital Fluorescence Lifetime Imaging of the Kidney Reveals Cell-Type Specific Metabolic Signatures. Journal of the American Society of Nephrology : JASN, 28 8, 2420-2430Jiang, Xi; Hu, Chao; Ferchen, Kyle; Nie, Ji; Cui, Xiaolong; Chen, Chih-Hong; Cheng, Liting; Zuo, Zhixiang; Seibel, William; He, Chunjiang; Tang, Yixuan; Skibbe, Jennifer R; Wunderlich, Mark; Reinhold, William C; Dong, Lei; Shen, Chao; Arnovitz, Stephen; Ulrich, Bryan; Lu, Jiuwei; Weng, Hengyou; Su, Rui; Huang, Huilin; Wang, Yungui; Li, Chenying; Qin, Xi; Mulloy, James C; Zheng, Yi; Diao, Jiajie; Jin, Jie; Li, Chong; Liu, Paul P; He, Chuan; Chen, Yuan; Chen, Jianjun 2017. Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia. Nature communications, 8 1, 2099Kalim, Khalid W; Zhang, Shuangmin; Chen, Xiaoyi; Li, Yuan; Yang, Jun-Qi; Zheng, Yi; Guo, Fukun 2017. mTOR has a developmental stage-specific role in mitochondrial fitness independent of conventional mTORC1 and mTORC2 and the kinase activity. PloS one, 12 8, e0183266Li, Jingjing; Miao, Lianjie; Zhao, Chen; Shaikh Qureshi, Wasay Mohiuddin; Shieh, David; Guo, Hua; Lu, Yangyang; Hu, Saiyang; Huang, Alice; Zhang, Lu; Cai, Chen-Leng; Wan, Leo Q; Xin, Hongbo; Vincent, Peter; Singer, Harold A; Zheng, Yi; Cleaver, Ondine; Fan, Zhen-Chuan; Wu, Mingfu 2017. CDC42 is required for epicardial and pro-epicardial development by mediating FGF receptor trafficking to the plasma membrane. Development (Cambridge, England), 144 9, 1635-1647Liu, Ming; Zhang, Zheng; Sampson, Leesa; Zhou, Xuan; Nalapareddy, Kodandaramireddy; Feng, Yuxin; Akunuru, Shailaja; Melendez, Jaime; Davis, Ashley Kuenzi; Bi, Feng; Geiger, Hartmut; Xin, Mei; Zheng, Yi 2017. RHOA GTPase Controls YAP-Mediated EREG Signaling in Small Intestinal Stem Cell Maintenance. Stem cell reports, 9 6, 1961-1975Mizukawa, Benjamin; O'Brien, Eric; Moreira, Daniel C; Wunderlich, Mark; Hochstetler, Cindy L; Duan, Xin; Liu, Wei; Orr, Emily; Grimes, H Leighton; Mulloy, James C; Zheng, Yi 2017. The cell polarity determinant CDC42 controls division symmetry to block leukemia cell differentiation. Blood, 130 11, 1336-1346Nalapareddy, Kodandaramireddy; Nattamai, Kalpana J; Kumar, Rupali S; Karns, Rebekah; Wikenheiser-Brokamp, Kathryn A; Sampson, Leesa L; Mahe, Maxime M; Sundaram, Nambirajan; Yacyshyn, Mary-Beth; Yacyshyn, Bruce; Helmrath, Michael A; Zheng, Yi; Geiger, Hartmut 2017. Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells. Cell reports, 18 11, 2608-2621Qiu, Sugan; Fan, Xiaolin; Yang, Yingying; Dong, Panpan; Zhou, Wei; Xu, Yongliang; Zhou, Yonghua; Guo, Fukun; Zheng, Yi; Yang, Jun-Qi 2017. Schistosoma japonicum infection downregulates house dust mite-induced allergic airway inflammation in mice. PloS one, 12 6, e0179565Sakabe, Masahide; Fan, Jieqing; Odaka, Yoshinobu; Liu, Ning; Hassan, Aishlin; Duan, Xin; Stump, Paige; Byerly, Luke; Donaldson, Megan; Hao, Jiukuan; Fruttiger, Marcus; Lu, Qing Richard; Zheng, Yi; Lang, Richard A; Xin, Mei 2017. YAP/TAZ-CDC42 signaling regulates vascular tip cell migration. Proceedings of the National Academy of Sciences of the United States of America, 114 41, 10918-10923Sinagoga, Katie L; Stone, William J; Schiesser, Jacqueline V; Schweitzer, Jamie I; Sampson, Leesa; Zheng, Yi; Wells, James M 2017. Distinct roles for the mTOR pathway in postnatal morphogenesis, maturation and function of pancreatic islets. Development (Cambridge, England), 144 13, 2402-2414Zandvakili, I; Lin, Y; Morris, J C; Zheng, Y 2017. Rho GTPases: Anti- or pro-neoplastic targets? Oncogene, 36 23, 3213-3222Barry, David M; Koo, Yeon; Norden, Pieter R; Wylie, Lyndsay A; Xu, Ke; Wichaidit, Chonlarat; Azizoglu, D Berfin; Zheng, Yi; Cobb, Melanie H; Davis, George E; Cleaver, Ondine 2016. Rasip1-Mediated Rho GTPase Signaling Regulates Blood Vessel Tubulogenesis via Nonmuscle Myosin II. Circulation research, 119 7, 810-26Imai, Fumiyasu; Ladle, David R; Leslie, Jennifer R; Duan, Xin; Rizvi, Tilat A; Ciraolo, Georgianne M; Zheng, Yi; Yoshida, Yutaka 2016. Synapse Formation in Monosynaptic Sensory-Motor Connections Is Regulated by Presynaptic Rho GTPase Cdc42. The Journal of neuroscience : the official journal of the Society for Neuroscience, 36 21, 5724-35Nohata, Nijiro; Uchida, Yutaka; Stratman, Amber N; Adams, Ralf H; Zheng, Yi; Weinstein, Brant M; Mukouyama, Yoh-Suke; Gutkind, J Silvio 2016. Temporal-specific roles of Rac1 during vascular development and retinal angiogenesis. Developmental biology, 411 2, 183-194O'Hayre, M; Inoue, A; Kufareva, I; Wang, Z; Mikelis, C M; Drummond, R A; Avino, S; Finkel, K; Kalim, K W; DiPasquale, G; Guo, F; Aoki, J; Zheng, Y; Lionakis, M S; Molinolo, A A; Gutkind, J S 2016. Inactivating mutations in GNA13 and RHOA in Burkitt's lymphoma and diffuse large B-cell lymphoma: a tumor suppressor function for the G?13/RhoA axis in B cells. Oncogene, 35 29, 3771-80Palazzo, A; Bluteau, O; Messaoudi, K; Marangoni, F; Chang, Y; Souquere, S; Pierron, G; Lapierre, V; Zheng, Y; Vainchenker, W; Raslova, H; Debili, N 2016. The cell division control protein 42-Src family kinase-neural Wiskott-Aldrich syndrome protein pathway regulates human proplatelet formation. Journal of thrombosis and haemostasis : JTH, 14 12, 2524-2535Sampson, Leesa L; Davis, Ashley K; Grogg, Matthew W; Zheng, Yi 2016. mTOR disruption causes intestinal epithelial cell defects and intestinal atrophy postinjury in mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 30 3, 1263-75Yang, Jun-Qi; Kalim, Khalid W; Li, Yuan; Zhang, Shuangmin; Hinge, Ashwini; Filippi, Marie-Dominique; Zheng, Yi; Guo, Fukun 2016. RhoA orchestrates glycolysis for TH2 cell differentiation and allergic airway inflammation. The Journal of allergy and clinical immunology, 137 1, 231-245.e4Barry, David M; Xu, Ke; Meadows, Stryder M; Zheng, Yi; Norden, Pieter R; Davis, George E; Cleaver, Ondine 2015. Cdc42 is required for cytoskeletal support of endothelial cell adhesion during blood vessel formation in mice. Development (Cambridge, England), 142 17, 3058-70Chang, Kyung Hee; Nayak, Ramesh C; Roy, Swarnava; Perumbeti, Ajay; Wellendorf, Ashley M; Bezold, Katie Y; Pirman, Megan; Hill, Sarah E; Starnes, Joseph; Loberg, Anastacia; Zhou, Xuan; Inagami, Tadashi; Zheng, Yi; Malik, Punam; Cancelas, Jose A 2015. Vasculopathy-associated hyperangiotensinemia mobilizes haematopoietic stem cells/progenitors through endothelial AT?R and cytoskeletal dysregulation. Nature communications, 6 , 5914Evelyn, Chris R; Biesiada, Jacek; Duan, Xin; Tang, Hong; Shang, Xun; Papoian, Ruben; Seibel, William L; Nelson, Sandra; Meller, Jaroslaw; Zheng, Yi 2015. Combined rational design and a high throughput screening platform for identifying chemical inhibitors of a Ras-activating enzyme. The Journal of biological chemistry, 290 20, 12879-98Kesarwani, Meenu; Huber, Erika; Kincaid, Zachary; Evelyn, Chris R; Biesiada, Jacek; Rance, Mark; Thapa, Mahendra B; Shah, Neil P; Meller, Jarek; Zheng, Yi; Azam, Mohammad 2015. Targeting substrate-site in Jak2 kinase prevents emergence of genetic resistance. Scientific reports, 5 , 14538Konstantinidis, Diamantis G; Giger, Katie M; Risinger, Mary; Pushkaran, Suvarnamala; Zhou, Ping; Dexheimer, Phillip; Yerneni, Satwica; Andreassen, Paul; Klingmüller, Ursula; Palis, James; Zheng, Yi; Kalfa, Theodosia A 2015. Cytokinesis failure in RhoA-deficient mouse erythroblasts involves actomyosin and midbody dysregulation and triggers p53 activation. Blood, 126 12, 1473-82Li, Juan; Zhang, Lei; Chen, Zhenzhong; Xie, Minjuan; Huang, Lu; Xue, Jinhua; Liu, Yutong; Liu, Nuyun; Guo, Fukun; Zheng, Yi; Kong, Jiming; Zhang, Lin; Zhang, Lu 2015. Cocaine activates Rac1 to control structural and behavioral plasticity in caudate putamen. Neurobiology of disease, 75 , 159-76Lin, Yuan; Zheng, Yi 2015. Approaches of targeting Rho GTPases in cancer drug discovery. Expert opinion on drug discovery, 10 9, 991-1010Mikelis, Constantinos M; Simaan, May; Ando, Koji; Fukuhara, Shigetomo; Sakurai, Atsuko; Amornphimoltham, Panomwat; Masedunskas, Andrius; Weigert, Roberto; Chavakis, Triantafyllos; Adams, Ralf H; Offermanns, Stefan; Mochizuki, Naoki; Zheng, Yi; Gutkind, J Silvio 2015. RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock. Nature communications, 6 , 6725Zandvakili, Inuk; Davis, Ashley Kuenzi; Hu, Guodong; Zheng, Yi 2015. Loss of RhoA Exacerbates, Rather Than Dampens, Oncogenic K-Ras Induced Lung Adenoma Formation in Mice. PloS one, 10 6, e0127923Delaney, Michael Keegan; Liu, Junling; Kim, Kyungho; Shen, Bo; Stojanovic-Terpo, Aleksandra; Zheng, Yi; Cho, Jaehyung; Du, Xiaoping 2014. Agonist-induced platelet procoagulant activity requires shear and a Rac1-dependent signaling mechanism. Blood, 124 12, 1957-67Evelyn, Chris R; Duan, Xin; Biesiada, Jacek; Seibel, William L; Meller, Jaroslaw; Zheng, Yi 2014. Rational design of small molecule inhibitors targeting the Ras GEF, SOS1. Chemistry & biology, 21 12, 1618-28Fabbiano, Salvatore; Menacho-Márquez, Mauricio; Sevilla, María A; Albarrán-Juárez, Julián; Zheng, Yi; Offermanns, Stefan; Montero, María J; Bustelo, Xosé R 2014. Genetic dissection of the vav2-rac1 signaling axis in vascular smooth muscle cells. Molecular and cellular biology, 34 24, 4404-19Geiger, Hartmut; Zheng, Yi 2014. Regulation of hematopoietic stem cell aging by the small RhoGTPase Cdc42. Experimental cell research, 329 2, 214-9Guo, F; Li, J; Zhang, S; Du, W; Amarachintha, S; Sipple, J; Phelan, J; Grimes, H L; Zheng, Y; Pang, Q 2014. mTOR kinase inhibitor sensitizes T-cell lymphoblastic leukemia for chemotherapy-induced DNA damage via suppressing FANCD2 expression. Leukemia, 28 1, 203-6Kalfa, Theodosia A; Zheng, Yi 2014. Rho GTPases in erythroid maturation. Current opinion in hematology, 21 3, 165-71Konstantinidis, Diamantis G; Pushkaran, Suvarnamala; Giger, Katie; Manganaris, Stefanos; Zheng, Yi; Kalfa, Theodosia A 2014. Identification of a murine erythroblast subpopulation enriched in enucleating events by multi-spectral imaging flow cytometry. Journal of visualized experiments : JoVE, 88, Sakamori, Ryotaro; Yu, Shiyan; Zhang, Xiao; Hoffman, Andrew; Sun, Jiaxin; Das, Soumyashree; Vedula, Pavan; Li, Guangxun; Fu, Jiang; Walker, Francesca; Yang, Chung S; Yi, Zheng; Hsu, Wei; Yu, Da-Hai; Shen, Lanlan; Rodriguez, Alexis J; Taketo, Makoto M; Bonder, Edward M; Verzi, Michael P; Gao, Nan 2014. CDC42 inhibition suppresses progression of incipient intestinal tumors. Cancer research, 74 19, 5480-92Zhang, Shuangmin; Konstantinidis, Diamantis G; Yang, Jun-Qi; Mizukawa, Benjamin; Kalim, Khalid; Lang, Richard A; Kalfa, Theodosia A; Zheng, Yi; Guo, Fukun 2014. Gene targeting RhoA reveals its essential role in coordinating mitochondrial function and thymocyte development. Journal of immunology (Baltimore, Md. : 1950), 193 12, 5973-82Zheng, Yi; Geiger, Hartmut 2014. HSPCs get their motors running for asymmetric fate choice. Cell stem cell, 14 1, 1-2Zhu, Yajie; Zhou, Jitao; Xia, Hongwei; Chen, Xiangzheng; Qiu, Meng; Huang, Juan; Liu, Surui; Tang, Qiulin; Lang, Nan; Liu, Zhen; Liu, Ming; Zheng, Yi; Bi, Feng 2014. The Rho GTPase RhoE is a p53-regulated candidate tumor suppressor in cancer cells. International journal of oncology, 44 3, 896-904Guo, F; Li, J; Du, W; Zhang, S; O'Connor, M; Thomas, G; Kozma, S; Zingarelli, B; Pang, Q; Zheng, Y 2013. mTOR regulates DNA damage response through NF-?B-mediated FANCD2 pathway in hematopoietic cells. Leukemia, 27 10, 2040-2046Guo, Li; Moon, Chandra; Zheng, Yi; Ratner, Nancy 2013. Cdc42 regulates Schwann cell radial sorting and myelin sheath folding through NF2/merlin-dependent and independent signaling. Glia, 61 11, 1906-21Katayama, Kei-ichi; Imai, Fumiyasu; Campbell, Kenneth; Lang, Richard A; Zheng, Yi; Yoshida, Yutaka 2013. RhoA and Cdc42 are required in pre-migratory progenitors of the medial ganglionic eminence ventricular zone for proper cortical interneuron migration. Development (Cambridge, England), 140 15, 3139-45Melendez, Jaime; Liu, Ming; Sampson, Leesa; Akunuru, Shailaja; Han, Xiaonan; Vallance, Jefferson; Witte, David; Shroyer, Noah; Zheng, Yi 2013. Cdc42 coordinates proliferation, polarity, migration, and differentiation of small intestinal epithelial cells in mice. Gastroenterology, 145 4, 808-19Shang, Xun; Marchioni, Fillipo; Evelyn, Chris R; Sipes, Nisha; Zhou, Xuan; Seibel, William; Wortman, Matthew; Zheng, Yi 2013. Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors. Proceedings of the National Academy of Sciences of the United States of America, 110 8, 3155-60Zhou, Xuan; Florian, Maria Carolina; Arumugam, Paritha; Chen, Xiaoyi; Cancelas, Jose A; Lang, Richard; Malik, Punam; Geiger, Hartmut; Zheng, Yi 2013. RhoA GTPase controls cytokinesis and programmed necrosis of hematopoietic progenitors. The Journal of experimental medicine, 210 11, 2371-85Zhou, Xuan; Zheng, Yi 2013. Cell type-specific signaling function of RhoA GTPase: lessons from mouse gene targeting. The Journal of biological chemistry, 288 51, 36179-88Akunuru, S; James Zhai, Q; Zheng, Y 2012. Non-small cell lung cancer stem/progenitor cells are enriched in multiple distinct phenotypic subpopulations and exhibit plasticity. Cell death & disease, 3 , e352Bosco, Emily E; Kumar, Sachin; Marchioni, Filippo; Biesiada, Jacek; Kordos, Miroslaw; Szczur, Kathleen; Meller, Jarek; Seibel, William; Mizrahi, Ariel; Pick, Edgar; Filippi, Marie-Dominique; Zheng, Yi 2012. Rational design of small molecule inhibitors targeting the Rac GTPase-p67(phox) signaling axis in inflammation. Chemistry & biology, 19 2, 228-42Chang, Kyung Hee; Sanchez-Aguilera, Abel; Shen, Shuhong; Sengupta, Amitava; Madhu, Malav N; Ficker, Ashley M; Dunn, Susan K; Kuenzi, Ashley M; Arnett, Jorden L; Santho, Rebecca A; Agirre, Xabier; Perentesis, John P; Deininger, Michael W; Zheng, Yi; Bustelo, Xose R; Williams, David A; Cancelas, Jose A 2012. Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival. Blood, 120 4, 800-11Guo, Li; Moon, Chandra; Niehaus, Karen; Zheng, Yi; Ratner, Nancy 2012. Rac1 controls Schwann cell myelination through cAMP and NF2/merlin. The Journal of neuroscience : the official journal of the Society for Neuroscience, 32 48, 17251-61Katayama, Kei-ichi; Leslie, Jennifer R; Lang, Richard A; Zheng, Yi; Yoshida, Yutaka 2012. Left-right locomotor circuitry depends on RhoA-driven organization of the neuroepithelium in the developing spinal cord. The Journal of neuroscience : the official journal of the Society for Neuroscience, 32 30, 10396-407Konstantinidis, Diamantis G; Pushkaran, Suvarnamala; Johnson, James F; Cancelas, Jose A; Manganaris, Stefanos; Harris, Chad E; Williams, David A; Zheng, Yi; Kalfa, Theodosia A 2012. Signaling and cytoskeletal requirements in erythroblast enucleation. Blood, 119 25, 6118-27Kumar, Sachin; Xu, Juying; Perkins, Charles; Guo, Fukun; Snapper, Scott; Finkelman, Fred D; Zheng, Yi; Filippi, Marie-Dominique 2012. Cdc42 regulates neutrophil migration via crosstalk between WASp, CD11b, and microtubules. Blood, 120 17, 3563-74Leslie, Jennifer R; Imai, Fumiyasu; Zhou, Xuan; Lang, Richard A; Zheng, Yi; Yoshida, Yutaka 2012. RhoA is dispensable for axon guidance of sensory neurons in the mouse dorsal root ganglia. Frontiers in molecular neuroscience, 5 , 67Liu, Ming; Bi, Feng; Zhou, Xuan; Zheng, Yi 2012. Rho GTPase regulation by miRNAs and covalent modifications. Trends in cell biology, 22 7, 365-73Shang, Xun; Marchioni, Fillipo; Sipes, Nisha; Evelyn, Chris R; Jerabek-Willemsen, Moran; Duhr, Stefan; Seibel, William; Wortman, Matthew; Zheng, Yi 2012. Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases. Chemistry & biology, 19 6, 699-710Shang, Xun; Zheng, Yi 2012. Rational design of Rho GTPase-targeting inhibitors. Methods in molecular biology (Clifton, N.J.), 928 , 29-38Tan, Zongqing; Wortman, Matthew; Dillehay, Kelsey L; Seibel, William L; Evelyn, Chris R; Smith, Shanna J; Malkas, Linda H; Zheng, Yi; Lu, Shan; Dong, Zhongyun 2012. Small-molecule targeting of proliferating cell nuclear antigen chromatin association inhibits tumor cell growth. Molecular pharmacology, 81 6, 811-9Akunuru, Shailaja; Palumbo, Joseph; Zhai, Qihui James; Zheng, Yi 2011. Rac1 targeting suppresses human non-small cell lung adenocarcinoma cancer stem cell activity. PloS one, 6 2, e16951Chauhan, Bharesh K; Lou, Ming; Zheng, Yi; Lang, Richard A 2011. Balanced Rac1 and RhoA activities regulate cell shape and drive invagination morphogenesis in epithelia. Proceedings of the National Academy of Sciences of the United States of America, 108 45, 18289-94Geh, Esmond; Meng, Qinghang; Mongan, Maureen; Wang, Jingcai; Takatori, Atsushi; Zheng, Yi; Puga, Alvaro; Lang, Richard A; Xia, Ying 2011. Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) integrates developmental signals for eyelid closure. Proceedings of the National Academy of Sciences of the United States of America, 108 42, 17349-54Guo, Fukun; Zhang, Shuangmin; Tripathi, Pulak; Mattner, Jochen; Phelan, James; Sproles, Alyssa; Mo, Jun; Wills-Karp, Marsha; Grimes, H Leighton; Hildeman, David; Zheng, Yi 2011. Distinct roles of Cdc42 in thymopoiesis and effector and memory T cell differentiation. PloS one, 6 3, e18002Katayama, Kei-ichi; Melendez, Jaime; Baumann, Jessica M; Leslie, Jennifer R; Chauhan, Bharesh K; Nemkul, Niza; Lang, Richard A; Kuan, Chia-Yi; Zheng, Yi; Yoshida, Yutaka 2011. Loss of RhoA in neural progenitor cells causes the disruption of adherens junctions and hyperproliferation. Proceedings of the National Academy of Sciences of the United States of America, 108 18, 7607-12Liu, Wei; Feng, Yuxin; Shang, Xun; Zheng, Yi 2011. Rho GTPases in hematopoietic stem/progenitor cell migration. Methods in molecular biology (Clifton, N.J.), 750 , 307-19Melendez, Jaime; Grogg, Matthew; Zheng, Yi 2011. Signaling role of Cdc42 in regulating mammalian physiology. The Journal of biological chemistry, 286 4, 2375-81Melendez, Jaime; Stengel, Kristy; Zhou, Xuan; Chauhan, Bharesh K; Debidda, Marcella; Andreassen, Paul; Lang, Richard A; Zheng, Yi 2011. RhoA GTPase is dispensable for actomyosin regulation but is essential for mitosis in primary mouse embryonic fibroblasts. The Journal of biological chemistry, 286 17, 15132-7Mizukawa, Benjamin; Wei, Junping; Shrestha, Mahesh; Wunderlich, Mark; Chou, Fu-Sheng; Griesinger, Andrea; Harris, Chad E; Kumar, Ashish R; Zheng, Yi; Williams, David A; Mulloy, James C 2011. Inhibition of Rac GTPase signaling and downstream prosurvival Bcl-2 proteins as combination targeted therapy in MLL-AF9 leukemia. Blood, 118 19, 5235-45Morrison, Monique A; Morreale, Richard J; Akunuru, Shailaja; Kofron, Matthew; Zheng, Yi; Wells, Susanne I 2011. Targeting the human papillomavirus E6 and E7 oncogenes through expression of the bovine papillomavirus type 1 E2 protein stimulates cellular motility. Journal of virology, 85 20, 10487-98Plageman, Timothy F; Chauhan, Bharesh K; Yang, Christine; Jaudon, Fanny; Shang, Xun; Zheng, Yi; Lou, Ming; Debant, Anne; Hildebrand, Jeffrey D; Lang, Richard A 2011. A Trio-RhoA-Shroom3 pathway is required for apical constriction and epithelial invagination. Development (Cambridge, England), 138 23, 5177-88Shang, Xun; Cancelas, Jose A; Li, Lina; Guo, Fukun; Liu, Wei; Johnson, James F; Ficker, Ashley; Daria, Deidre; Geiger, Hartmut; Ratner, Nancy; Zheng, Yi 2011. R-Ras and Rac GTPase cross-talk regulates hematopoietic progenitor cell migration, homing, and mobilization. The Journal of biological chemistry, 286 27, 24068-78Sipes, Nisha S; Feng, Yuxin; Guo, Fukun; Lee, Hyung-Ok; Chou, Fu-Sheng; Cheng, Jonathan; Mulloy, James; Zheng, Yi 2011. Cdc42 regulates extracellular matrix remodeling in three dimensions. The Journal of biological chemistry, 286 42, 36469-77Stengel, Kristy; Zheng, Yi 2011. Cdc42 in oncogenic transformation, invasion, and tumorigenesis. Cellular signalling, 23 9, 1415-23Wang, Xiaofang; Zhang, Fan; Chen, Fanping; Liu, Dou; Zheng, Yi; Zhang, Yongliang; Dong, Chen; Su, Bing 2011. MEKK3 regulates IFN-gamma production in T cells through the Rac1/2-dependent MAPK cascades. Journal of immunology (Baltimore, Md. : 1950), 186 10, 5791-800Bosco, E E; Nakai, Y; Hennigan, R F; Ratner, N; Zheng, Y 2010. NF2-deficient cells depend on the Rac1-canonical Wnt signaling pathway to promote the loss of contact inhibition of proliferation. Oncogene, 29 17, 2540-9Bosco, Emily E; Ni, Wenjun; Wang, Lei; Guo, Fukun; Johnson, James F; Zheng, Yi 2010. Rac1 targeting suppresses p53 deficiency-mediated lymphomagenesis. Blood, 115 16, 3320-8George, Alex; Pushkaran, Suvarnamala; Li, Lina; An, Xiuli; Zheng, Yi; Mohandas, Narla; Joiner, Clinton H; Kalfa, Theodosia A 2010. Altered phosphorylation of cytoskeleton proteins in sickle red blood cells: the role of protein kinase C, Rac GTPases, and reactive oxygen species. Blood cells, molecules & diseases, 45 1, 41-5Guo, Fukun; Hildeman, David; Tripathi, Pulak; Velu, Chinavenmeni S; Grimes, H Leighton; Zheng, Yi 2010. Coordination of IL-7 receptor and T-cell receptor signaling by cell-division cycle 42 in T-cell homeostasis. Proceedings of the National Academy of Sciences of the United States of America, 107 43, 18505-10Kalfa, Theodosia A; Pushkaran, Suvarnamala; Zhang, Xiaoling; Johnson, James F; Pan, Dao; Daria, Deidre; Geiger, Hartmut; Cancelas, Jose A; Williams, David A; Zheng, Yi 2010. Rac1 and Rac2 GTPases are necessary for early erythropoietic expansion in the bone marrow but not in the spleen. Haematologica, 95 1, 27-35Mulloy, James C; Cancelas, Jose A; Filippi, Marie-Dominique; Kalfa, Theodosia A; Guo, Fukun; Zheng, Yi 2010. Rho GTPases in hematopoiesis and hemopathies. Blood, 115 5, 936-47Mulloy, James C; Cancelas, Jose A; Filippi, Marie-Dominique; Kalfa, Theodosia A; Guo, Fukun; Zheng, Yi 2010. Rho GTPases in hematopoiesis and hemopathies. Blood, 115 5, 936-47Ryan, Marnie A; Nattamai, Kalpana J; Xing, Ellen; Schleimer, David; Daria, Deidre; Sengupta, Amitava; Köhler, Anja; Liu, Wei; Gunzer, Matthias; Jansen, Michael; Ratner, Nancy; Le Cras, Timothy D; Waterstrat, Amanda; Van Zant, Gary; Cancelas, Jose A; Zheng, Yi; Geiger, Hartmut 2010. Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilization. Nature medicine, 16 10, 1141-6Bosco, E E; Mulloy, J C; Zheng, Y 2009. Rac1 GTPase: a "Rac" of all trades. Cellular and molecular life sciences : CMLS, 66 3, 370-4Chauhan, Bharesh K; Disanza, Andrea; Choi, Sue-Yeon; Faber, Sonya C; Lou, Ming; Beggs, Hilary E; Scita, Giorgio; Zheng, Yi; Lang, Richard A 2009. Cdc42- and IRSp53-dependent contractile filopodia tether presumptive lens and retina to coordinate epithelial invagination. Development (Cambridge, England), 136 21, 3657-67Chen, Lei; Melendez, Jaime; Campbell, Kenneth; Kuan, Chia-Yi; Zheng, Yi 2009. Rac1 deficiency in the forebrain results in neural progenitor reduction and microcephaly. Developmental biology, 325 1, 162-70Guo, Fukun; Velu, Chinavenmeni S; Grimes, H Leighton; Zheng, Yi 2009. Rho GTPase Cdc42 is essential for B-lymphocyte development and activation. Blood, 114 14, 2909-16Maillet, Marjorie; Lynch, Jeffrey M; Sanna, Bastiano; York, Allen J; Zheng, Yi; Molkentin, Jeffery D 2009. Cdc42 is an antihypertrophic molecular switch in the mouse heart. The Journal of clinical investigation, 119 10, 3079-88Marchioni, Filippo; Zheng, Yi 2009. Targeting rho GTPases by peptidic structures. Current pharmaceutical design, 15 21, 2481-7Milsom, Michael D; Lee, Andrew W; Zheng, Yi; Cancelas, Jose A 2009. Fanca-/- hematopoietic stem cells demonstrate a mobilization defect which can be overcome by administration of the Rac inhibitor NSC23766. Haematologica, 94 7, 1011-5Szczur, Kathleen; Zheng, Yi; Filippi, Marie-Dominique 2009. The small Rho GTPase Cdc42 regulates neutrophil polarity via CD11b integrin signaling. Blood, 114 20, 4527-37Xu, Haiming; Eleswarapu, Satyam; Geiger, Hartmut; Szczur, Kathleen; Daria, Deidre; Zheng, Yi; Settleman, Jeffrey; Srour, Edward F; Williams, David A; Filippi, Marie-Dominique 2009. Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential. Blood, 114 17, 3557-66Mulloy, James C; Wunderlich, Mark; Zheng, Yi; Wei, Junping 2008. Transforming human blood stem and progenitor cells: a new way forward in leukemia modeling. Cell cycle (Georgetown, Tex.), 7 21, 3314-9Thomas, E K; Cancelas, J A; Zheng, Y; Williams, D A 2008. Rac GTPases as key regulators of p210-BCR-ABL-dependent leukemogenesis. Leukemia, 22 5, 898-904Wei, Junping; Wunderlich, Mark; Fox, Catherine; Alvarez, Sara; Cigudosa, Juan C; Wilhelm, Jamie S; Zheng, Yi; Cancelas, Jose A; Gu, Yi; Jansen, Michael; Dimartino, Jorge F; Mulloy, James C 2008. Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia. Cancer cell, 13 6, 483-95Williams, David A; Zheng, Yi; Cancelas, Jose A 2008. Rho GTPases and regulation of hematopoietic stem cell localization. Methods in enzymology, 439 , 365-93Zhang, Xiaoling; Shang, Xun; Guo, Fukun; Murphy, Kim; Kirby, Michelle; Kelly, Patrick; Reeves, Lilith; Smith, Franklin O; Williams, David A; Zheng, Yi; Pang, Qishen 2008. Defective homing is associated with altered Cdc42 activity in cells from patients with Fanconi anemia group A. Blood, 112 5, 1683-6Akbar, H; Kim, J; Funk, K; Cancelas, J A; Shang, X; Chen, L; Johnson, J F; Williams, D A; Zheng, Y 2007. Genetic and pharmacologic evidence that Rac1 GTPase is involved in regulation of platelet secretion and aggregation. Journal of thrombosis and haemostasis : JTH, 5 8, 1747-55Chen, Lei; Liao, Guanghong; Waclaw, Ronald R; Burns, Kevin A; Linquist, Diana; Campbell, Kenneth; Zheng, Yi; Kuan, Chia-Yi 2007. Rac1 controls the formation of midline commissures and the competency of tangential migration in ventral telencephalic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience, 27 14, 3884-93Guo, Dagang; Tan, Ying-cai; Wang, Dawei; Madhusoodanan, K S; Zheng, Yi; Maack, Thomas; Zhang, J Jillian; Huang, Xin-Yun 2007. A Rac-cGMP signaling pathway. Cell, 128 2, 341-55Shang, Xun; Moon, Sun Young; Zheng, Yi 2007. p200 RhoGAP promotes cell proliferation by mediating cross-talk between Ras and Rho signaling pathways. The Journal of biological chemistry, 282 12, 8801-11Thomas, Emily K; Cancelas, Jose A; Chae, Hee-Don; Cox, Adrienne D; Keller, Patricia J; Perrotti, Danilo; Neviani, Paolo; Druker, Brian J; Setchell, Kenneth D R; Zheng, Yi; Harris, Chad E; Williams, David A 2007. Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease. Cancer cell, 12 5, 467-78Thomas, Emily K; Cancelas, Jose A; Chae, Hee-Don; Cox, Adrienne D; Keller, Patricia J; Perrotti, Danilo; Neviani, Paolo; Druker, Brian J; Setchell, Kenneth D R; Zheng, Yi; Harris, Chad E; Williams, David A 2007. Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease. Cancer cell, 12 5, 467-78Wang, Lei; Yang, Linda; Debidda, Marcella; Witte, David; Zheng, Yi 2007. Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes. Proceedings of the National Academy of Sciences of the United States of America, 104 4, 1248-53Wang, Lei; Zheng, Yi 2007. Cell type-specific functions of Rho GTPases revealed by gene targeting in mice. Trends in cell biology, 17 2, 58-64Yang, Linda; Wang, Lei; Geiger, Hartmut; Cancelas, Jose A; Mo, Jun; Zheng, Yi 2007. Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrow. Proceedings of the National Academy of Sciences of the United States of America, 104 12, 5091-6Yang, Linda; Wang, Lei; Kalfa, Theodosia A; Cancelas, Jose A; Shang, Xun; Pushkaran, Suvarnamala; Mo, Jun; Williams, David A; Zheng, Yi 2007. Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis. Blood, 110 12, 3853-61Yang, Linda; Zheng, Yi 2007. Cdc42: a signal coordinator in hematopoietic stem cell maintenance. Cell cycle (Georgetown, Tex.), 6 12, 1445-50Akbar, Huzoor; Cancelas, Jose; Williams, David A; Zheng, Jie; Zheng, Yi 2006. Rational design and applications of a Rac GTPase-specific small molecule inhibitor. Methods in enzymology, 406 , 554-65Chen, Lei; Liao, Guanghong; Yang, Linda; Campbell, Kenneth; Nakafuku, Masato; Kuan, Chia-Yi; Zheng, Yi 2006. Cdc42 deficiency causes Sonic hedgehog-independent holoprosencephaly. Proceedings of the National Academy of Sciences of the United States of America, 103 44, 16520-5Debidda, Marcella; Williams, David A; Zheng, Yi 2006. Rac1 GTPase regulates cell genomic stability and senescence. The Journal of biological chemistry, 281 50, 38519-28Ghiaur, Gabriel; Lee, Andrew; Bailey, Jeff; Cancelas, Jose A; Zheng, Yi; Williams, David A 2006. Inhibition of RhoA GTPase activity enhances hematopoietic stem and progenitor cell proliferation and engraftment. Blood, 108 6, 2087-94Gu, Y; Siefring, J E; Wang, L; Chae, H-D; Bailey, J R; Zheng, Y 2006. Oncogenic Vav1 induces Rac-dependent apoptosis via inhibition of Bcl-2 family proteins and collaborates with p53 deficiency to promote hematopoietic progenitor cell proliferation. Oncogene, 25 28, 3963-72Guo, Fukun; Debidda, Marcella; Yang, Linda; Williams, David A; Zheng, Yi 2006. Genetic deletion of Rac1 GTPase reveals its critical role in actin stress fiber formation and focal adhesion complex assembly. The Journal of biological chemistry, 281 27, 18652-9Kalfa, Theodosia A; Pushkaran, Suvarnamala; Mohandas, Narla; Hartwig, John H; Fowler, Velia M; Johnson, James F; Joiner, Clinton H; Williams, David A; Zheng, Yi 2006. Rac GTPases regulate the morphology and deformability of the erythrocyte cytoskeleton. Blood, 108 12, 3637-45Nakai, Yoko; Zheng, Yi; MacCollin, Mia; Ratner, Nancy 2006. Temporal control of Rac in Schwann cell-axon interaction is disrupted in NF2-mutant schwannoma cells. The Journal of neuroscience : the official journal of the Society for Neuroscience, 26 13, 3390-5Nakai, Yoko; Zheng, Yi; MacCollin, Mia; Ratner, Nancy 2006. Temporal control of Rac in Schwann cell-axon interaction is disrupted in NF2-mutant schwannoma cells. The Journal of neuroscience : the official journal of the Society for Neuroscience, 26 13, 3390-5Nassar, Nicolas; Cancelas, Jose; Zheng, Jie; Williams, David A; Zheng, Yi 2006. Structure-function based design of small molecule inhibitors targeting Rho family GTPases. Current topics in medicinal chemistry, 6 11, 1109-16Szczur, Kathleen; Xu, Haiming; Atkinson, Simon; Zheng, Yi; Filippi, Marie-Dominique 2006. Rho GTPase CDC42 regulates directionality and random movement via distinct MAPK pathways in neutrophils. Blood, 108 13, 4205-13Wang, Lei; Yang, Linda; Filippi, Marie-Dominique; Williams, David A; Zheng, Yi 2006. Genetic deletion of Cdc42GAP reveals a role of Cdc42 in erythropoiesis and hematopoietic stem/progenitor cell survival, adhesion, and engraftment. Blood, 107 1, 98-105Xing, Zhenlan; Ryan, Marnie A; Daria, Deidre; Nattamai, Kalpana J; Van Zant, Gary; Wang, Lei; Zheng, Yi; Geiger, Hartmut 2006. Increased hematopoietic stem cell mobilization in aged mice. Blood, 108 7, 2190-7Yang, Linda; Wang, Lei; Zheng, Yi 2006. Gene targeting of Cdc42 and Cdc42GAP affirms the critical involvement of Cdc42 in filopodia induction, directed migration, and proliferation in primary mouse embryonic fibroblasts. Molecular biology of the cell, 17 11, 4675-85Cancelas, Jose A; Lee, Andrew W; Prabhakar, Rethinasamy; Stringer, Keith F; Zheng, Yi; Williams, David A 2005. Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization. Nature medicine, 11 8, 886-91Carstanjen, Dirk; Yamauchi, Akira; Koornneef, Annemart; Zang, Heesuk; Filippi, Marie-Dominique; Harris, Chad; Towe, Jason; Atkinson, Simon; Zheng, Yi; Dinauer, Mary C; Williams, David A 2005. Rac2 regulates neutrophil chemotaxis, superoxide production, and myeloid colony formation through multiple distinct effector pathways. Journal of immunology (Baltimore, Md. : 1950), 174 8, 4613-20Debidda, Marcella; Wang, Lei; Zang, Heesuk; Poli, Valeria; Zheng, Yi 2005. A role of STAT3 in Rho GTPase-regulated cell migration and proliferation. The Journal of biological chemistry, 280 17, 17275-85Gu, Yi; Zheng, Yi; Williams, David A 2005. RhoH GTPase: a key regulator of hematopoietic cell proliferation and apoptosis? Cell cycle (Georgetown, Tex.), 4 2, 201-2Wang, Lei; Yang, Linda; Burns, Kevin; Kuan, Chia-Yi; Zheng, Yi 2005. Cdc42GAP regulates c-Jun N-terminal kinase (JNK)-mediated apoptosis and cell number during mammalian perinatal growth. Proceedings of the National Academy of Sciences of the United States of America, 102 38, 13484-9Zhang, Lin; Deng, Maoxian; Parthasarathy, Ranjani; Wang, Lei; Mongan, Maureen; Molkentin, Jeffery D; Zheng, Yi; Xia, Ying 2005. MEKK1 transduces activin signals in keratinocytes to induce actin stress fiber formation and migration. Molecular and cellular biology, 25 1, 60-5Cook-Mills, Joan M; Johnson, Jacob D; Deem, Tracy L; Ochi, Atsuo; Wang, Lei; Zheng, Yi 2004. Calcium mobilization and Rac1 activation are required for VCAM-1 (vascular cell adhesion molecule-1) stimulation of NADPH oxidase activity. The Biochemical journal, 378 Pt 2, 539-47Debreceni, Balazs; Gao, Yuan; Guo, Fukun; Zhu, Kejin; Jia, Baoqing; Zheng, Yi 2004. Mechanisms of guanine nucleotide exchange and Rac-mediated signaling revealed by a dominant negative trio mutant. The Journal of biological chemistry, 279 5, 3777-86Filippi, Marie-Dominique; Harris, Chad E; Meller, Jarek; Gu, Yi; Zheng, Yi; Williams, David A 2004. Localization of Rac2 via the C terminus and aspartic acid 150 specifies superoxide generation, actin polarity and chemotaxis in neutrophils. Nature immunology, 5 7, 744-51Gao, Yuan; Dickerson, J Bradley; Guo, Fukun; Zheng, Jie; Zheng, Yi 2004. Rational design and characterization of a Rac GTPase-specific small molecule inhibitor. Proceedings of the National Academy of Sciences of the United States of America, 101 20, 7618-23Guo, Fukun; Zheng, Yi 2004. Rho family GTPases cooperate with p53 deletion to promote primary mouse embryonic fibroblast cell invasion. Oncogene, 23 33, 5577-85Guo, Fukun; Zheng, Yi 2004. Involvement of Rho family GTPases in p19Arf- and p53-mediated proliferation of primary mouse embryonic fibroblasts. Molecular and cellular biology, 24 3, 1426-38Wang, Lei; Zhu, Kejin; Zheng, Yi 2004. Oncogenic Dbl, Cdc42, and p21-activated kinase form a ternary signaling intermediate through the minimum interactive domains. Biochemistry, 43 46, 14584-93Guo, Fukun; Gao, Yuan; Wang, Lei; Zheng, Yi 2003. p19Arf-p53 tumor suppressor pathway regulates cell motility by suppression of phosphoinositide 3-kinase and Rac1 GTPase activities. The Journal of biological chemistry, 278 16, 14414-9Moon, Sun Young; Zang, Heesuk; Zheng, Yi 2003. Characterization of a brain-specific Rho GTPase-activating protein, p200RhoGAP. The Journal of biological chemistry, 278 6, 4151-9Moon, Sun Young; Zheng, Yi 2003. Rho GTPase-activating proteins in cell regulation. Trends in cell biology, 13 1, 13-22Wang, Lei; Yang, Linda; Luo, Yongneng; Zheng, Yi 2003. A novel strategy for specifically down-regulating individual Rho GTPase activity in tumor cells. The Journal of biological chemistry, 278 45, 44617-25Zheng, Yi; Quilliam, Lawrence A 2003. Activation of the Ras superfamily of small GTPases. Workshop on exchange factors. EMBO reports, 4 5, 463-8Akbar, Huzoor; Duan, Xin; Saleem, Saima; Davis, Ashley K; Zheng, Yi . RhoA and Rac1 GTPases Differentially Regulate Agonist-Receptor Mediated Reactive Oxygen Species Generation in Platelets. PloS one, 11 9, e0163227