Contact Information Medical Sciences Building 3205 Office 513-558-6279 Email yanbg@ucmail.uc.edu Peer Reviewed Publications Hu J, Wang Y, Mao Z, Ning R, Liu W, Xiong J, Yan B, Yang J 2017. Icariin protects against glucocorticoid induced osteoporosis, increases the expression of the bone enhancer DEC1 and modulates the PI3K/Akt/GSK3β/β-catenin integrated signaling pathway Biochem Pharmacol, 136: , 109-121Li Y, Cupo M, Guo L, Scott J, Chen YT, Yan B, Lu W 2017. Enhanced reactive oxygen species through direct copper sulfide nanoparticle-doxorubicin complexation. Nanotechnology. , 28: , 505101.Marczak MM, Yan B 2017. Circadian rhythmicity: A functional connection between differentiated embryo-chondrocyte-expressed gene 1 and small heterodimer partner. Arch Biochem Biophys, 631 , 11-18Ning R, Zhan Y, He S, Hu J, Zhu Z, Hu G, Yan B, Yang J, Liu W 2017. Interleukin-6 induces DEC1, promotes DEC1 interaction with RXRαand suppresses the expression of PXR, CAR and their target genes. Front Pharmacol., 8: , 866Shen Y, Yan B 2017. Covalent inhibition of carboxylesterase-2 by sofosbuvir and its effect on the hydrolytic activation of tenofovir disoproxil J Hepatol, 66: , 660-661Wu L, Hafiz MZ, Guan Y, He S, Xiong J, Liu W, Yan B, Li X, Yang J 2017. 17β-Estradiol suppresses carboxylesterases by activating c-Jun/AP-1 pathway in primary human and mouse hepatocytes. Eur J Pharmacol. , 819: , 98-107Vachirayonsti T, Yan B 2016. MicroRNA-30c-1 suppresses the pregnane X receptor by targeting the 3’-untranslated region and alters the expression of its target gene cytochrome P450 3A4. BBA-Gene Regulatory Mechanisms. , 1859: , 1238–1244.Chen Y, Valanejad L, Song X, Valanejad L, Verma R, You S, Yan B, Shiffka S, Hargreaves L, Nadolny C, Deng R 2015. ) Estrogen and estrogen receptor-α mediated transrepression of bile salt export pump Mol Endocrinol. , 29: , 613-626Chen YZ, Trzoss L, Yang D, Yan B 2015. Ontogenic expression of carboxylesterase-2 and cytochrome P450 3A4 in liver and duodenum: Postnatal surge and organ-dependent regulation. Toxicology. , 330: , 55-61Vachirayonsti T, Yang D, Yan B 2015. Suppression of the pregnane X receptor during endoplasmic reticulum stress is achieved by down-regulating hepatocyte nuclear factor-4 and up-regulating liver-enriched inhibitory protein. Toxicol Sci. , 144:382-392. , 382-392.Xu J, Donepudi AC, More VR, Kulkarni SR, Li L, Guo L, Yan B, Chatterjee T, Weintraub N, Slitt AL 2015. Deficiency in Nrf2 transcription factor decreases adipose tissue mass and hepatic lipid accumulation in leptin-deficient mice Obesity. , 23: , 335-344Guo L, Yan DD, Yang D, Li Y, Wang X, Zalewski O, Yan B, Lu W 2014. Combinatorial photothermal and immunocancer therapy using chitosan-coated hollow copper sulfide nanoparticles. ACS Nano., 8: , 5670-5681Song X, Vasilenko A, Chen Y, Valanejad L, Verma R, Yan B, Deng R 2014. Transrepression of BSEP by 17beta-estradiol in Intrahepatic Cholestasis of Pregnancy through ERalpha/FXR interaction. Hepatology., 60: , 1993-2007Chen Y, Song X, Vasilenko A, Valanejad L, More V, Qiu X, Chen W, Lai Y, Slitt A, Stoner M, Yan B, Deng R . Bile salt export pump is dysregulated with altered farnesoid x receptor isoform expression in patients with hepatocellular carcinoma tissues. Hepatology. , 57: , 1530-1541.Guo L, Panderi I, Yan DD, Szulak K, Li Y, Chen YT, Ma H, Niesen D, Seeram NP, Ahmed A, Yan B, Pantazato D, Lu W . A comparative study of hollow CuS nanoparticles and hollow gold nanospheres on degradability and toxicity. ACS Nano. , 7: , 8780-8793. Mao Z, Luan X, Cao G, Liu W, Xiong J, Hu G, Chen R, Ning R, Shang W, Yang J, Yan B . DEC1 binding to the proximal promoter of CYP3A4 ascribes to the downregulation of CYP3A4 expression by IL-6 in primary human hepatocytes. Biochem Pharmacol. , 84: , 701-711Song X, Chen Y, Valanejad L, Kaimal R, Stoner M, Yan B, Deng R . Mechanistic Insights into Isoform-dependent and Species-specific Regulation of Bile Salt Export Pump by Farnesoid X Receptor. J Lipid Res. , 54: , 3030-3044.Xiao D, Shi D, Yang D, Barthel B, Koch TH, Yan B . Carboxylesterase-2 is a highly sensitive target of the antiobesity agent orlistat with profound clinical implications in the activation of anticancer prodrugs. Biochem Pharmacol. , 85: , 439–447Xiao D, Yang D, Guo L, Lu W, Charpentier M, Yan B . Regulation of carboxylesterase-2 expression by p53 family proteins and enhanced anticancer activities among 5-fluorouracil, irinotecan and doxazolidine prodrug. Brit J Pharmacol. , 168: , 1989-1999.
Peer Reviewed Publications Hu J, Wang Y, Mao Z, Ning R, Liu W, Xiong J, Yan B, Yang J 2017. Icariin protects against glucocorticoid induced osteoporosis, increases the expression of the bone enhancer DEC1 and modulates the PI3K/Akt/GSK3β/β-catenin integrated signaling pathway Biochem Pharmacol, 136: , 109-121Li Y, Cupo M, Guo L, Scott J, Chen YT, Yan B, Lu W 2017. Enhanced reactive oxygen species through direct copper sulfide nanoparticle-doxorubicin complexation. Nanotechnology. , 28: , 505101.Marczak MM, Yan B 2017. Circadian rhythmicity: A functional connection between differentiated embryo-chondrocyte-expressed gene 1 and small heterodimer partner. Arch Biochem Biophys, 631 , 11-18Ning R, Zhan Y, He S, Hu J, Zhu Z, Hu G, Yan B, Yang J, Liu W 2017. Interleukin-6 induces DEC1, promotes DEC1 interaction with RXRαand suppresses the expression of PXR, CAR and their target genes. Front Pharmacol., 8: , 866Shen Y, Yan B 2017. Covalent inhibition of carboxylesterase-2 by sofosbuvir and its effect on the hydrolytic activation of tenofovir disoproxil J Hepatol, 66: , 660-661Wu L, Hafiz MZ, Guan Y, He S, Xiong J, Liu W, Yan B, Li X, Yang J 2017. 17β-Estradiol suppresses carboxylesterases by activating c-Jun/AP-1 pathway in primary human and mouse hepatocytes. Eur J Pharmacol. , 819: , 98-107Vachirayonsti T, Yan B 2016. MicroRNA-30c-1 suppresses the pregnane X receptor by targeting the 3’-untranslated region and alters the expression of its target gene cytochrome P450 3A4. BBA-Gene Regulatory Mechanisms. , 1859: , 1238–1244.Chen Y, Valanejad L, Song X, Valanejad L, Verma R, You S, Yan B, Shiffka S, Hargreaves L, Nadolny C, Deng R 2015. ) Estrogen and estrogen receptor-α mediated transrepression of bile salt export pump Mol Endocrinol. , 29: , 613-626Chen YZ, Trzoss L, Yang D, Yan B 2015. Ontogenic expression of carboxylesterase-2 and cytochrome P450 3A4 in liver and duodenum: Postnatal surge and organ-dependent regulation. Toxicology. , 330: , 55-61Vachirayonsti T, Yang D, Yan B 2015. Suppression of the pregnane X receptor during endoplasmic reticulum stress is achieved by down-regulating hepatocyte nuclear factor-4 and up-regulating liver-enriched inhibitory protein. Toxicol Sci. , 144:382-392. , 382-392.Xu J, Donepudi AC, More VR, Kulkarni SR, Li L, Guo L, Yan B, Chatterjee T, Weintraub N, Slitt AL 2015. Deficiency in Nrf2 transcription factor decreases adipose tissue mass and hepatic lipid accumulation in leptin-deficient mice Obesity. , 23: , 335-344Guo L, Yan DD, Yang D, Li Y, Wang X, Zalewski O, Yan B, Lu W 2014. Combinatorial photothermal and immunocancer therapy using chitosan-coated hollow copper sulfide nanoparticles. ACS Nano., 8: , 5670-5681Song X, Vasilenko A, Chen Y, Valanejad L, Verma R, Yan B, Deng R 2014. Transrepression of BSEP by 17beta-estradiol in Intrahepatic Cholestasis of Pregnancy through ERalpha/FXR interaction. Hepatology., 60: , 1993-2007Chen Y, Song X, Vasilenko A, Valanejad L, More V, Qiu X, Chen W, Lai Y, Slitt A, Stoner M, Yan B, Deng R . Bile salt export pump is dysregulated with altered farnesoid x receptor isoform expression in patients with hepatocellular carcinoma tissues. Hepatology. , 57: , 1530-1541.Guo L, Panderi I, Yan DD, Szulak K, Li Y, Chen YT, Ma H, Niesen D, Seeram NP, Ahmed A, Yan B, Pantazato D, Lu W . A comparative study of hollow CuS nanoparticles and hollow gold nanospheres on degradability and toxicity. ACS Nano. , 7: , 8780-8793. Mao Z, Luan X, Cao G, Liu W, Xiong J, Hu G, Chen R, Ning R, Shang W, Yang J, Yan B . DEC1 binding to the proximal promoter of CYP3A4 ascribes to the downregulation of CYP3A4 expression by IL-6 in primary human hepatocytes. Biochem Pharmacol. , 84: , 701-711Song X, Chen Y, Valanejad L, Kaimal R, Stoner M, Yan B, Deng R . Mechanistic Insights into Isoform-dependent and Species-specific Regulation of Bile Salt Export Pump by Farnesoid X Receptor. J Lipid Res. , 54: , 3030-3044.Xiao D, Shi D, Yang D, Barthel B, Koch TH, Yan B . Carboxylesterase-2 is a highly sensitive target of the antiobesity agent orlistat with profound clinical implications in the activation of anticancer prodrugs. Biochem Pharmacol. , 85: , 439–447Xiao D, Yang D, Guo L, Lu W, Charpentier M, Yan B . Regulation of carboxylesterase-2 expression by p53 family proteins and enhanced anticancer activities among 5-fluorouracil, irinotecan and doxazolidine prodrug. Brit J Pharmacol. , 168: , 1989-1999.
Hu J, Wang Y, Mao Z, Ning R, Liu W, Xiong J, Yan B, Yang J 2017. Icariin protects against glucocorticoid induced osteoporosis, increases the expression of the bone enhancer DEC1 and modulates the PI3K/Akt/GSK3β/β-catenin integrated signaling pathway Biochem Pharmacol, 136: , 109-121Li Y, Cupo M, Guo L, Scott J, Chen YT, Yan B, Lu W 2017. Enhanced reactive oxygen species through direct copper sulfide nanoparticle-doxorubicin complexation. Nanotechnology. , 28: , 505101.Marczak MM, Yan B 2017. Circadian rhythmicity: A functional connection between differentiated embryo-chondrocyte-expressed gene 1 and small heterodimer partner. Arch Biochem Biophys, 631 , 11-18Ning R, Zhan Y, He S, Hu J, Zhu Z, Hu G, Yan B, Yang J, Liu W 2017. Interleukin-6 induces DEC1, promotes DEC1 interaction with RXRαand suppresses the expression of PXR, CAR and their target genes. Front Pharmacol., 8: , 866Shen Y, Yan B 2017. Covalent inhibition of carboxylesterase-2 by sofosbuvir and its effect on the hydrolytic activation of tenofovir disoproxil J Hepatol, 66: , 660-661Wu L, Hafiz MZ, Guan Y, He S, Xiong J, Liu W, Yan B, Li X, Yang J 2017. 17β-Estradiol suppresses carboxylesterases by activating c-Jun/AP-1 pathway in primary human and mouse hepatocytes. Eur J Pharmacol. , 819: , 98-107Vachirayonsti T, Yan B 2016. MicroRNA-30c-1 suppresses the pregnane X receptor by targeting the 3’-untranslated region and alters the expression of its target gene cytochrome P450 3A4. BBA-Gene Regulatory Mechanisms. , 1859: , 1238–1244.Chen Y, Valanejad L, Song X, Valanejad L, Verma R, You S, Yan B, Shiffka S, Hargreaves L, Nadolny C, Deng R 2015. ) Estrogen and estrogen receptor-α mediated transrepression of bile salt export pump Mol Endocrinol. , 29: , 613-626Chen YZ, Trzoss L, Yang D, Yan B 2015. Ontogenic expression of carboxylesterase-2 and cytochrome P450 3A4 in liver and duodenum: Postnatal surge and organ-dependent regulation. Toxicology. , 330: , 55-61Vachirayonsti T, Yang D, Yan B 2015. Suppression of the pregnane X receptor during endoplasmic reticulum stress is achieved by down-regulating hepatocyte nuclear factor-4 and up-regulating liver-enriched inhibitory protein. Toxicol Sci. , 144:382-392. , 382-392.Xu J, Donepudi AC, More VR, Kulkarni SR, Li L, Guo L, Yan B, Chatterjee T, Weintraub N, Slitt AL 2015. Deficiency in Nrf2 transcription factor decreases adipose tissue mass and hepatic lipid accumulation in leptin-deficient mice Obesity. , 23: , 335-344Guo L, Yan DD, Yang D, Li Y, Wang X, Zalewski O, Yan B, Lu W 2014. Combinatorial photothermal and immunocancer therapy using chitosan-coated hollow copper sulfide nanoparticles. ACS Nano., 8: , 5670-5681Song X, Vasilenko A, Chen Y, Valanejad L, Verma R, Yan B, Deng R 2014. Transrepression of BSEP by 17beta-estradiol in Intrahepatic Cholestasis of Pregnancy through ERalpha/FXR interaction. Hepatology., 60: , 1993-2007Chen Y, Song X, Vasilenko A, Valanejad L, More V, Qiu X, Chen W, Lai Y, Slitt A, Stoner M, Yan B, Deng R . Bile salt export pump is dysregulated with altered farnesoid x receptor isoform expression in patients with hepatocellular carcinoma tissues. Hepatology. , 57: , 1530-1541.Guo L, Panderi I, Yan DD, Szulak K, Li Y, Chen YT, Ma H, Niesen D, Seeram NP, Ahmed A, Yan B, Pantazato D, Lu W . A comparative study of hollow CuS nanoparticles and hollow gold nanospheres on degradability and toxicity. ACS Nano. , 7: , 8780-8793. Mao Z, Luan X, Cao G, Liu W, Xiong J, Hu G, Chen R, Ning R, Shang W, Yang J, Yan B . DEC1 binding to the proximal promoter of CYP3A4 ascribes to the downregulation of CYP3A4 expression by IL-6 in primary human hepatocytes. Biochem Pharmacol. , 84: , 701-711Song X, Chen Y, Valanejad L, Kaimal R, Stoner M, Yan B, Deng R . Mechanistic Insights into Isoform-dependent and Species-specific Regulation of Bile Salt Export Pump by Farnesoid X Receptor. J Lipid Res. , 54: , 3030-3044.Xiao D, Shi D, Yang D, Barthel B, Koch TH, Yan B . Carboxylesterase-2 is a highly sensitive target of the antiobesity agent orlistat with profound clinical implications in the activation of anticancer prodrugs. Biochem Pharmacol. , 85: , 439–447Xiao D, Yang D, Guo L, Lu W, Charpentier M, Yan B . Regulation of carboxylesterase-2 expression by p53 family proteins and enhanced anticancer activities among 5-fluorouracil, irinotecan and doxazolidine prodrug. Brit J Pharmacol. , 168: , 1989-1999.