Contact Information Childrens Hospital Bldg R Office 513-803-5317 Email starcydl@ucmail.uc.edu Research InterestsThe Starczynowski Lab has an interest in understanding the molecular and cellular basis of hematologic malignancies, with an emphasis on Myelodysplastic Syndromes and Acute Myeloid Leukemia. Peer Reviewed Publications Laranjeira, Angelo Brunelli Albertoni; Kong, Tim; Snyder, Steven C; Fulbright, Mary C; Fisher, Daniel A C; Starczynowski, Daniel T; Oh, Stephen T 2024. In vivo ablation of NFκB cascade effectors alleviates disease burden in myeloproliferative neoplasms. Blood, , Venkatasubramanian, Meenakshi; Schwartz, Leya; Ramachandra, Nandini; Bennett, Joshua; Subramanian, Krithika R; Chen, Xiaoting; Gordon-Mitchell, Shanisha; Fromowitz, Ariel; Pradhan, Kith; Shechter, David; Sahu, Srabani; Heiser, Diane; Scherle, Peggy; Chetal, Kashish; Kulkarni, Aishwarya; Myers, Kasiani C; Weirauch, Matthew T; Grimes, H Leighton; Starczynowski, Daniel T; Verma, Amit; Salomonis, Nathan 2024. Broad de-regulated U2AF1 splicing is prognostic and augments leukemic transformation via protein arginine methyltransferase activation. bioRxiv : the preprint server for biology, , Bennett, Joshua; Ishikawa, Chiharu; Agarwal, Puneet; Yeung, Jennifer; Sampson, Avery; Uible, Emma; Vick, Eric; Bolanos, Lyndsey C; Hueneman, Kathleen; Wunderlich, Mark; Kolt, Amal; Choi, Kwangmin; Volk, Andrew; Greis, Kenneth D; Rosenbaum, Jan; Hoyt, Scott B; Thomas, Craig J; Starczynowski, Daniel T 2023. Paralog-specific signaling by IRAK1/4 maintains MyD88-independent functions in MDS/AML. Blood, 142 11, 989-1007Bewersdorf, Jan Philipp; Xie, Zhuoer; Bejar, Rafael; Borate, Uma; Boultwood, Jacqueline; Brunner, Andrew M; Buckstein, Rena; Carraway, Hetty E; Churpek, Jane E; Daver, Naval G; Porta, Matteo Giovanni Della; DeZern, Amy E; Fenaux, Pierre; Figueroa, Maria E; Gore, Steven D; Griffiths, Elizabeth A; Halene, Stephanie; Hasserjian, Robert P; Hourigan, Christopher S; Kim, Tae Kon; Komrokji, Rami; Kuchroo, Vijay K; List, Alan F; Loghavi, Sanam; Majeti, Ravindra; Odenike, Olatoyosi; Patnaik, Mrinal M; Platzbecker, Uwe; Roboz, Gail J; Sallman, David A; Santini, Valeria; Sanz, Guillermo; Sekeres, Mikkael A; Stahl, Maximilian; Starczynowski, Daniel T; Steensma, David P; Taylor, Justin; Abdel-Wahab, Omar; Xu, Mina L; Savona, Michael R; Wei, Andrew H; Zeidan, Amer M 2023. Current landscape of translational and clinical research in myelodysplastic syndromes/neoplasms (MDS): Proceedings from the 1st International Workshop on MDS (iwMDS) Of the International Consortium for MDS (icMDS). Blood reviews, 60 , 101072Dean, Sarai T; Ishikawa, Chiharu; Zhu, Xiaoqin; Walulik, Sean; Nixon, Timothy; Jordan, Jessica K; Henderson, Samantha; Wyder, Michael; Salomonis, Nathan; Wunderlich, Mark; Greis, Kenneth D; Starczynowski, Daniel T; Volk, Andrew G 2023. Repression of TRIM13 by chromatin assembly factor CHAF1B is critical for AML development. Blood advances, 7 17, 4822-4837Gorak, Edward J; Otterstatter, Michael; Al Baghdadi, Tareq; Gillis, Nancy; Foran, James M; Liu, Jane Jijun; Bejar, Rafael; Gore, Steven D; Kroft, Steven H; Harrington, Alexandra; Saber, Wael; Starczynowski, Daniel; Rollison, Dana E; Zhang, Ling; Moscinski, Lynn; Wilson, Steffanie; Thompson, Jason; Borchert, Christine; Sherman, Seth; Hebert, Donnie; Walker, Mary Ellen; Padron, Eric; DeZern, Amy E; Sekeres, Mikkael A 2023. Discordant pathologic diagnoses of myelodysplastic neoplasms and their implications for registries and therapies. Blood advances, 7 20, 6120-6129Marion, William; Koppe, Tiago; Chen, Chun-Chin; Wang, Dahai; Frenis, Katie; Fierstein, Sara; Sensharma, Prerana; Aumais, Olivia; Peters, Michael; Ruiz-Torres, Sonya; Chihanga, Tafadzwa; Boettcher, Steffen; Shimamura, Akiko; Bauer, Daniel E; Schlaeger, Thorsten; Wells, Susanne I; Ebert, Benjamin L; Starczynowski, Daniel; da Rocha, Edroaldo Lummertz; Rowe, R Grant 2023. RUNX1 mutations mitigate quiescence to promote transformation of hematopoietic progenitors in Fanconi anemia. Leukemia, 37 8, 1698-1708Muto, Tomoya; Walker, Callum S; Agarwal, Puneet; Vick, Eric; Sampson, Avery; Choi, Kwangmin; Niederkorn, Madeline; Ishikawa, Chiharu; Hueneman, Kathleen; Varney, Melinda; Starczynowski, Daniel T 2023. Inactivation of p53 provides a competitive advantage to del(5q) myelodysplastic syndrome hematopoietic stem cells during inflammation. Haematologica, 108 10, 2715-2729Riabov, Vladimir; Xu, Qingyu; Schmitt, Nanni; Streuer, Alexander; Ge, Guo; Bolanos, Lyndsey; Wunderlich, Mark; Jann, Johann-Christoph; Wein, Alina; Altrock, Eva; Demmerle, Marie; Mukherjee, Sanjay; Ali, Abdullah Mahmood; Rapp, Felicitas; Nowak, Verena; Weimer, Nadine; Obländer, Julia; Palme, Iris; Göl, Melda; Jawhar, Ahmed; Darwich, Ali; Wuchter, Patrick; Weiss, Christel; Raza, Azra; Foulks, Jason M; Starczynowski, Daniel T; Yang, Feng-Chun; Metzgeroth, Georgia; Steiner, Laurenz; Jawhar, Mohamad; Hofmann, Wolf-Karsten; Nowak, Daniel 2023. ASXL1 mutations are associated with a response to alvocidib and 5-azacytidine combination in myelodysplastic neoplasms. Haematologica, , Stahl, Maximilian; Abdel-Wahab, Omar; Wei, Andrew H; Savona, Michael R; Xu, Mina L; Xie, Zhuoer; Taylor, Justin; Starczynowski, Daniel; Sanz, Guillermo F; Sallman, David A; Santini, Valeria; Roboz, Gail J; Patnaik, Mrinal M; Padron, Eric; Odenike, Olatoyosi; Nazha, Aziz; Nimer, Stephen D; Majeti, Ravindra; Little, Richard F; Gore, Steven; List, Alan F; Kutchroo, Vijay; Komrokji, Rami S; Kim, Tae Kon; Kim, Nina; Hourigan, Christopher S; Hasserjian, Robert P; Halene, Stephanie; Griffiths, Elizabeth A; Greenberg, Peter L; Figueroa, Maria; Fenaux, Pierre; Efficace, Fabio; DeZern, Amy E; Della Porta, Matteo G; Daver, Naval G; Churpek, Jane E; Carraway, Hetty E; Brunner, Andrew M; Borate, Uma; Bennett, John M; Bejar, Rafael; Boultwood, Jacqueline; Loghavi, Sanam; Bewersdorf, Jan Philipp; Platzbecker, Uwe; Steensma, David P; Sekeres, Mikkael A; Buckstein, Rena J; Zeidan, Amer M 2023. An agenda to advance research in myelodysplastic syndromes: a TOP 10 priority list from the first international workshop in MDS. Blood advances, 7 12, 2709-2714Stahl, Maximilian; Bewersdorf, Jan Philipp; Xie, Zhuoer; Porta, Matteo Giovanni Della; Komrokji, Rami; Xu, Mina L; Abdel-Wahab, Omar; Taylor, Justin; Steensma, David P; Starczynowski, Daniel T; Sekeres, Mikkael A; Sanz, Guillermo; Sallman, David A; Roboz, Gail J; Platzbecker, Uwe; Patnaik, Mrinal M; Padron, Eric; Odenike, Olatoyosi; Nimer, Stephen D; Nazha, Aziz; Majeti, Ravi; Loghavi, Sanam; Little, Richard F; List, Alan F; Kim, Tae Kon; Hourigan, Christopher S; Hasserjian, Robert P; Halene, Stephanie; Griffiths, Elizabeth A; Gore, Steven D; Greenberg, Peter; Figueroa, Maria E; Fenaux, Pierre; Efficace, Fabio; DeZern, Amy E; Daver, Naval G; Churpek, Jane E; Carraway, Hetty E; Buckstein, Rena; Brunner, Andrew M; Boultwood, Jacqueline; Borate, Uma; Bejar, Rafael; Bennett, John M; Wei, Andrew H; Santini, Valeria; Savona, Michael R; Zeidan, Amer M 2023. Classification, risk stratification and response assessment in myelodysplastic syndromes/neoplasms (MDS): A state-of-the-art report on behalf of the International Consortium for MDS (icMDS). Blood reviews, 62 , 101128Xie, Zhuoer; Starczynowski, Daniel T 2023. Are DDX41 variants of unknown significance and pathogenic variants created equal? Haematologica, 108 11, 2883-2885Aoyagi, Yasushige; Hayashi, Yoshihiro; Harada, Yuka; Choi, Kwangmin; Matsunuma, Natsumi; Sadato, Daichi; Maemoto, Yuki; Ito, Akihiro; Yanagi, Shigeru; Starczynowski, Daniel T; Harada, Hironori 2022. Mitochondrial Fragmentation Triggers Ineffective Hematopoiesis in Myelodysplastic Syndromes. Cancer discovery, 12 1, 250-269Azhar, Mohammad; Kincaid, Zachary; Kesarwani, Meenu; Ahmed, Arhama; Wunderlich, Mark; Latif, Tahir; Starczynowski, Daniel; Azam, Mohammad 2022. Momelotinib is a highly potent inhibitor of FLT3-mutant AML. Blood advances, 6 4, 1186-1192Barreyro, Laura; Sampson, Avery M; Ishikawa, Chiharu; Hueneman, Kathleen M; Choi, Kwangmin; Pujato, Mario A; Chutipongtanate, Somchai; Wyder, Michael; Haffey, Wendy D; O'Brien, Eric; Wunderlich, Mark; Ramesh, Vighnesh; Kolb, Ellen M; Meydan, Cem; Neelamraju, Yaseswini; Bolanos, Lyndsey C; Christie, Susanne; Smith, Molly A; Niederkorn, Madeline; Muto, Tomoya; Kesari, Santosh; Garrett-Bakelman, Francine E; Bartholdy, Boris; Will, Britta; Weirauch, Matthew T; Mulloy, James C; Gul, Zartash; Medlin, Stephen; Kovall, Rhett A; Melnick, Ari M; Perentesis, John P; Greis, Kenneth D; Nurmemmedov, Elmar; Seibel, William L; Starczynowski, Daniel T 2022. Blocking UBE2N abrogates oncogenic immune signaling in acute myeloid leukemia. Science translational medicine, 14 635, eabb7695Bennett, Joshua; Starczynowski, Daniel T 2022. IRAK1 and IRAK4 as emerging therapeutic targets in hematologic malignancies. Current opinion in hematology, 29 1, 8-19Choudhary, Gaurav S; Pellagatti, Andrea; Agianian, Bogos; Smith, Molly A; Bhagat, Tushar D; Gordon-Mitchell, Shanisha; Sahu, Srabani; Pandey, Sanjay; Shah, Nishi; Aluri, Srinivas; Aggarwal, Ritesh; Aminov, Sarah; Schwartz, Leya; Steeples, Violetta; Booher, Robert N; Ramachandra, Murali; Samson, Maria; Carbajal, Milagros; Pradhan, Kith; Bowman, Teresa V; Pillai, Manoj M; Will, Britta; Wickrema, Amittha; Shastri, Aditi; Bradley, Robert K; Martell, Robert E; Steidl, Ulrich G; Gavathiotis, Evripidis; Boultwood, Jacqueline; Starczynowski, Daniel T; Verma, Amit 2022. Activation of targetable inflammatory immune signaling is seen in myelodysplastic syndromes with SF3B1 mutations. eLife, 11 , Jones, LaQuita M; Starczynowski, Daniel T 2022. IKAROS and MENIN in synergy in AML. Nature cancer, 3 5, 528-529Muto, Tomoya; Guillamot, Maria; Yeung, Jennifer; Fang, Jing; Bennett, Joshua; Nadorp, Bettina; Lasry, Audrey; Redondo, Luna Zea; Choi, Kwangmin; Gong, Yixiao; Walker, Callum S; Hueneman, Kathleen; Bolanos, Lyndsey C; Barreyro, Laura; Lee, Lynn H; Greis, Kenneth D; Vasyliev, Nikita; Khodadadi-Jamayran, Alireza; Nudler, Evgeny; Lujambio, Amaia; Lowe, Scott W; Aifantis, Iannis; Starczynowski, Daniel T 2022. TRAF6 functions as a tumor suppressor in myeloid malignancies by directly targeting MYC oncogenic activity. Cell stem cell, 29 2, 298-314.e9Niederkorn, Madeline; Ishikawa, Chiharu; M Hueneman, Kathleen; Bartram, James; Stepanchick, Emily; R Bennett, Joshua; E Culver-Cochran, Ashley; Bolanos, Lyndsey C; Uible, Emma; Choi, Kwangmin; Wunderlich, Mark; Perentesis, John P; M Chlon, Timothy; Filippi, Marie-Dominique; Starczynowski, Daniel T 2022. The deubiquitinase USP15 modulates cellular redox and is a therapeutic target in acute myeloid leukemia. Leukemia, 36 2, 438-451Yeaton, Anna; Cayanan, Geraldine; Loghavi, Sanam; Dolgalev, Igor; Leddin, Emmett M; Loo, Christian E; Torabifard, Hedieh; Nicolet, Deedra; Wang, Jingjing; Corrigan, Kate; Paraskevopoulou, Varvara; Starczynowski, Daniel T; Wang, Eric; Abdel-Wahab, Omar; Viny, Aaron D; Stone, Richard M; Byrd, John C; Guryanova, Olga A; Kohli, Rahul M; Cisneros, G Andrés; Tsirigos, Aristotelis; Eisfeld, Ann-Kathrin; Aifantis, Iannis; Guillamot, Maria 2022. The Impact of Inflammation-Induced Tumor Plasticity during Myeloid Transformation. Cancer discovery, 12 10, 2392-2413Zeidan, Amer M; Bewersdorf, Jan Philipp; Buckstein, Rena; Sekeres, Mikkael A; Steensma, David P; Platzbecker, Uwe; Loghavi, Sanam; Boultwood, Jacqueline; Bejar, Rafael; Bennett, John M; Borate, Uma; Brunner, Andrew M; Carraway, Hetty; Churpek, Jane E; Daver, Naval G; Della Porta, Matteo; DeZern, Amy E; Efficace, Fabio; Fenaux, Pierre; Figueroa, Maria E; Greenberg, Peter; Griffiths, Elizabeth A; Halene, Stephanie; Hasserjian, Robert P; Hourigan, Christopher S; Kim, Nina; Kim, Tae Kon; Komrokji, Rami S; Kutchroo, Vijay; List, Alan F; Little, Richard F; Majeti, Ravi; Nazha, Aziz; Nimer, Stephen D; Odenike, Olatoyosi; Padron, Eric; Patnaik, Mrinal M; Roboz, Gail J; Sallman, David A; Sanz, Guillermo; Stahl, Maximilian; Starczynowski, Daniel T; Taylor, Justin; Xie, Zhuoer; Xu, Mina; Savona, Michael R; Wei, Andrew H; Abdel-Wahab, Omar; Santini, Valeria 2022. Finding consistency in classifications of myeloid neoplasms: a perspective on behalf of the International Workshop for Myelodysplastic Syndromes. Leukemia, 36 12, 2939-2946Zhang, Yang; Chen, Xiaoyi; Wang, Huamin; Gordon-Mitchell, Shanisha; Sahu, Srabani; Bhagat, Tushar D; Choudhary, Gaurav; Aluri, Srinivas; Pradhan, Kith; Sahu, Plabani; Carbajal, Milagros; Zhang, Hui; Agarwal, Beamon; Shastri, Aditi; Martell, Robert; Starczynowski, Daniel; Steidl, Ulrich; Maitra, Anirban; Verma, Amit 2022. Correction: Innate immune mediator, Interleukin-1 receptor accessory protein (IL1RAP), is expressed and pro-tumorigenic in pancreatic cancer. Journal of hematology & oncology, 15 1, 100Zhang, Yang; Chen, Xiaoyi; Wang, Huamin; Gordon-Mitchell, Shanisha; Sahu, Srabani; Bhagat, Tushar D; Choudhary, Gaurav; Aluri, Srinivas; Pradhan, Kith; Sahu, Plabani; Carbajal, Milagros; Zhang, Hui; Agarwal, Beamon; Shastri, Aditi; Martell, Robert; Starczynowski, Daniel; Steidl, Ulrich; Maitra, Anirban; Verma, Amit 2022. Innate immune mediator, Interleukin-1 receptor accessory protein (IL1RAP), is expressed and pro-tumorigenic in pancreatic cancer. Journal of hematology & oncology, 15 1, 70Agarwal, Puneet; Li, Hui; Choi, Kwangmin; Hueneman, Kathleen; He, Jianbo; Welner, Robert S; Starczynowski, Daniel T; Bhatia, Ravi 2021. TNF-α-induced alterations in stromal progenitors enhance leukemic stem cell growth via CXCR2 signaling. Cell reports, 36 2, 109386Chlon, Timothy M; Stepanchick, Emily; Hershberger, Courtney E; Daniels, Noah J; Hueneman, Kathleen M; Kuenzi Davis, Ashley; Choi, Kwangmin; Zheng, Yi; Gurnari, Carmelo; Haferlach, Torsten; Padgett, Richard A; Maciejewski, Jaroslaw P; Starczynowski, Daniel T 2021. Germline DDX41 mutations cause ineffective hematopoiesis and myelodysplasia. Cell stem cell, 28 11, 1966-1981.e6Serrano-Lopez, Juana; Hegde, Shailaja; Kumar, Sachin; Serrano, Josefina; Fang, Jing; Wellendorf, Ashley M; Roche, Paul A; Rangel, Yamileth; Carrington, Leolene J; Geiger, Hartmut; Grimes, H Leighton; Luther, Sanjiv; Maillard, Ivan; Sanchez-Garcia, Joaquin; Starczynowski, Daniel T; Cancelas, Jose A 2021. Inflammation rapidly recruits mammalian GMP and MDP from bone marrow into regional lymphatics. eLife, 10 , Trowbridge, Jennifer J; Starczynowski, Daniel T 2021. Innate immune pathways and inflammation in hematopoietic aging, clonal hematopoiesis, and MDS. The Journal of experimental medicine, 218 7, Wang, Tiansu; Pine, Allison R; Kotini, Andriana G; Yuan, Han; Zamparo, Lee; Starczynowski, Daniel T; Leslie, Christina; Papapetrou, Eirini P 2021. Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of myeloid leukemia and identifies early disease targets. Cell stem cell, 28 6, 1074-1089.e7Jones, LaQuita M; Melgar, Katelyn; Bolanos, Lyndsey; Hueneman, Kathleen; Walker, Morgan M; Jiang, Jian-Kang; Wilson, Kelli M; Zhang, Xiaohu; Shen, Jian; Jiang, Fan; Sutter, Patrick; Wang, Amy; Xu, Xin; Tawa, Gregory J; Hoyt, Scott B; Wunderlich, Mark; O'Brien, Eric; Perentesis, John P; Starczynowski, Daniel T; Thomas, Craig J 2020. Targeting AML-associated FLT3 mutations with a type I kinase inhibitor. The Journal of clinical investigation, , Muto, Tomoya; Walker, Callum S; Choi, Kwangmin; Hueneman, Kathleen; Smith, Molly A; Gul, Zartash; Garcia-Manero, Guillermo; Ma, Averil; Zheng, Yi; Starczynowski, Daniel T 2020. Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs. Nature immunology, 21 5, 535-545Niederkorn, Madeline; Agarwal, Puneet; Starczynowski, Daniel T 2020. TIFA and TIFAB: FHA-domain proteins involved in inflammation, hematopoiesis, and disease. Experimental hematology, 90 , 18-29Niederkorn, Madeline; Hueneman, Kathleen; Choi, Kwangmin; Varney, Melinda E; Romano, Laurel; Pujato, Mario A; Greis, Kenneth D; Inoue, Jun-Ichiro; Meetei, Ruhikanta; Starczynowski, Daniel T 2020. TIFAB Regulates USP15-Mediated p53 Signaling during Stressed and Malignant Hematopoiesis. Cell reports, 30 8, 2776-2790.e6Schieber, Michael; Marinaccio, Christian; Bolanos, Lyndsey C; Haffey, Wendy D; Greis, Kenneth D; Starczynowski, Daniel T; Crispino, John D 2020. FBXO11 is a candidate tumor suppressor in the leukemic transformation of myelodysplastic syndrome. Blood cancer journal, 10 10, 98Smith, Molly A; Culver-Cochran, Ashley E; Adelman, Emmalee R; Rhyasen, Garrett W; Ma, Averil; Figueroa, Maria E; Starczynowski, Daniel T 2020. TNFAIP3 Plays a Role in Aging of the Hematopoietic System. Frontiers in immunology, 11 , 536442Starczynowski, Daniel T 2020. HHEX expression drives AML development. Blood, 136 14, 1575-1576Melgar, Katelyn; Walker, Morgan M; Jones, LaQuita M; Bolanos, Lyndsey C; Hueneman, Kathleen; Wunderlich, Mark; Jiang, Jiang-Kang; Wilson, Kelli M; Zhang, Xiaohu; Sutter, Patrick; Wang, Amy; Xu, Xin; Choi, Kwangmin; Tawa, Gregory; Lorimer, Donald; Abendroth, Jan; O'Brien, Eric; Hoyt, Scott B; Berman, Ellin; Famulare, Christopher A; Mulloy, James C; Levine, Ross L; Perentesis, John P; Thomas, Craig J; Starczynowski, Daniel T 2019. Overcoming adaptive therapy resistance in AML by targeting immune response pathways. Science translational medicine, 11 508, Rawat, Radhika; Starczynowski, Daniel T; Ntziachristos, Panagiotis 2019. Nuclear deubiquitination in the spotlight: the multifaceted nature of USP7 biology in disease. Current opinion in cell biology, 58 , 85-94Sekeres, Mikkael A; Gore, Steven D; Stablein, Donald M; DiFronzo, Nancy; Abel, Gregory A; DeZern, Amy E; Troy, Jesse D; Rollison, Dana E; Thomas, John W; Waclawiw, Myron A; Liu, Jane Jijun; Al Baghdadi, Tareq; Walter, Matthew J; Bejar, Rafael; Gorak, Edward J; Starczynowski, Daniel T; Foran, James M; Cerhan, James R; Moscinski, Lynn C; Komrokji, Rami S; Deeg, H Joachim; Epling-Burnette, Pearlie K 2019. The National MDS Natural History Study: design of an integrated data and sample biorepository to promote research studies in myelodysplastic syndromes. Leukemia & lymphoma, , 1-11Smith, Molly A; Choudhary, Gaurav S; Pellagatti, Andrea; Choi, Kwangmin; Bolanos, Lyndsey C; Bhagat, Tushar D; Gordon-Mitchell, Shanisha; Von Ahrens, Dagny; Pradhan, Kith; Steeples, Violetta; Kim, Sanghyun; Steidl, Ulrich; Walter, Matthew; Fraser, Iain D C; Kulkarni, Aishwarya; Salomonis, Nathan; Komurov, Kakajan; Boultwood, Jacqueline; Verma, Amit; Starczynowski, Daniel T 2019. U2AF1 mutations induce oncogenic IRAK4 isoforms and activate innate immune pathways in myeloid malignancies. Nature cell biology, , Barreyro, Laura; Chlon, Timothy M; Starczynowski, Daniel T 2018. Chronic immune response dysregulation in MDS pathogenesis. Blood, 132 15, 1553-1560Culver-Cochran, Ashley E; Starczynowski, Daniel T 2018. Chronic innate immune signaling results in ubiquitination of splicing machinery. Cell cycle (Georgetown, Tex.), , 1-4Fang, Jing; Muto, Tomoya; Kleppe, Maria; Bolanos, Lyndsey C; Hueneman, Kathleen M; Walker, Callum S; Sampson, Leesa; Wellendorf, Ashley M; Chetal, Kashish; Choi, Kwangmin; Salomonis, Nathan; Choi, Yongwon; Zheng, Yi; Cancelas, Jose A; Levine, Ross L; Starczynowski, Daniel T 2018. TRAF6 Mediates Basal Activation of NF-κB Necessary for Hematopoietic Stem Cell Homeostasis. Cell reports, 22 5, 1250-1262Wei, Yue; Zheng, Hong; Bao, Naran; Jiang, Shan; Bueso-Ramos, Carlos E; Khoury, Joseph; Class, Caleb; Lu, Yue; Lin, Kevin; Yang, Hui; Ganan-Gomez, Irene; Starczynowski, Daniel T; Do, Kim-Anh; Colla, Simona; Garcia-Manero, Guillermo 2018. KDM6B overexpression activates innate immune signaling and impairs hematopoiesis in mice. Blood advances, 2 19, 2491-2504Fang, Jing; Bolanos, Lyndsey C; Choi, Kwangmin; Liu, Xiaona; Christie, Susanne; Akunuru, Shailaja; Kumar, Rupali; Wang, Dehua; Chen, Xiaoting; Greis, Kenneth D; Stoilov, Peter; Filippi, Marie-Dominique; Maciejewski, Jaroslaw P; Garcia-Manero, Guillermo; Weirauch, Matthew T; Salomonis, Nathan; Geiger, Hartmut; Zheng, Yi; Starczynowski, Daniel T 2017. Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia. Nature Immunology, 18 2, 236-245Fang, Jing; Bolanos, Lyndsey C; Choi, Kwangmin; Liu, Xiaona; Christie, Susanne; Akunuru, Shailaja; Kumar, Rupali; Wang, Dehua; Chen, Xiaoting; Greis, Kenneth D; Stoilov, Peter; Filippi, Marie-Dominique; Maciejewski, Jaroslaw P; Garcia-Manero, Guillermo; Weirauch, Matthew T; Salomonis, Nathan; Geiger, Hartmut; Zheng, Yi; Starczynowski, Daniel T 2017. Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia. Nature immunology, 18 2, 236-245Kong, Fansheng; Liu, Zhiwei; Jain, Viral G; Shima, Kenjiro; Suzuki, Takuji; Muglia, Louis J; Starczynowski, Daniel T; Pasare, Chandrashekhar; Bhattacharyya, Sandip 2017. Inhibition of IRAK1 Ubiquitination Determines Glucocorticoid Sensitivity for TLR9-Induced Inflammation in Macrophages. Journal of immunology (Baltimore, Md. : 1950), 199 10, 3654-3667Niederkorn, Madeline; Starczynowski, Daniel T 2017. GMP-ing to Spatial Conclusions about Emergency and Leukemic Myelopoiesis. Cell stem cell, 20 5, 579-581Varney, M E; Choi, K; Bolanos, L; Christie, S; Fang, J; Grimes, H L; Maciejewski, J P; Inoue, J-I; Starczynowski, D T 2017. Epistasis between TIFAB and miR-146a: neighboring genes in del(5q) myelodysplastic syndrome. Leukemia, 31 2, 491-495Fang J, Liu X, Bolanos L, Barker B, Rigolino C, Cortelezzi A, Oliva EN, Cuzzola M, Grimes HL, Fontanillo C, Komurov K, MacBeth K, Starczynowski DT 2016. A calcium- and calpain-dependent pathway determines the response to lenalidomide in myelodysplastic syndromes Nature Medicine, 22 7, 727Fang, Jing; Liu, Xiaona; Bolanos, Lyndsey; Barker, Brenden; Rigolino, Carmela; Cortelezzi, Agostino; Oliva, Esther N; Cuzzola, Maria; Grimes, H Leighton; Fontanillo, Celia; Komurov, Kakajan; MacBeth, Kyle; Starczynowski, Daniel T 2016. A calcium- and calpain-dependent pathway determines the response to lenalidomide in myelodysplastic syndromes. Nature medicine, 22 7, 727-34Shimizu, Ryo; Muto, Tomoya; Aoyama, Kazumasa; Choi, Kwangmin; Takeuchi, Masahiro; Koide, Shuhei; Hasegawa, Nagisa; Isshiki, Yusuke; Togasaki, Emi; Kawajiri-Manako, Chika; Nagao, Yuhei; Tsukamoto, Shokichi; Sakai, Shio; Takeda, Yusuke; Mimura, Naoya; Ohwada, Chikako; Sakaida, Emiko; Iseki, Tohru; Starczynowski, Daniel T; Iwama, Atsushi; Yokote, Koutaro; Nakaseko, Chiaki 2016. Possible role of intragenic DNA hypermethylation in gene silencing of the tumor suppressor gene NR4A3 in acute myeloid leukemia. Leukemia research, 50 , 85-94Varney ME, Choi K, Bolanos L, Christie S, Fang J, Grimes HL, Maciejewski JP, Inoue JI, Starczynowski DT 2016. Epistasis between TIFAB and miR-146a: neighboring genes in del(5q) myelodysplastic syndrome Leukemia, 50 , 85Adams AK, Bolanos LC, Dexheimer PJ, Karns RA, Aronow BJ, Komurov K, Jegga AG, Casper KA, Patil YJ, Wilson KM, Starczynowski DT, Wells SI 2015. IRAK1 is a novel DEK transcriptional target and is essential for head and neck cancer cell survival Oncotarget, 6 41, 43395Adams, Allie K; Bolanos, Lyndsey C; Dexheimer, Phillip J; Karns, Rebekah A; Aronow, Bruce J; Komurov, Kakajan; Jegga, Anil G; Casper, Keith A; Patil, Yash J; Wilson, Keith M; Starczynowski, Daniel T; Wells, Susanne I 2015. IRAK1 is a novel DEK transcriptional target and is essential for head and neck cancer cell survival. Oncotarget, 6 41, 43395-407Fang, Jing; Starczynowski, Daniel T 2015. Genomic instability establishes dependencies on acquired gene regulatory networks: A novel role of p62 in myeloid malignancies with del(5q). Molecular & cellular oncology, 2 4, e1014219Gañán-Gómez, I; Wei, Y; Starczynowski, D T; Colla, S; Yang, H; Cabrero-Calvo, M; Bohannan, Z S; Verma, A; Steidl, U; Garcia-Manero, G 2015. Deregulation of innate immune and inflammatory signaling in myelodysplastic syndromes. Leukemia, 29 7, 1458-69Gentner, Bernhard; Pochert, Nicole; Rouhi, Arefeh; Boccalatte, Francesco; Plati, Tiziana; Berg, Tobias; Sun, Su Ming; Mah, Sarah M; Mirkovic-Hösle, Milijana; Ruschmann, Jens; Muranyi, Andrew; Leierseder, Simon; Argiropoulos, Bob; Starczynowski, Daniel T; Karsan, Aly; Heuser, Michael; Hogge, Donna; Camargo, Fernando D; Engelhardt, Stefan; Döhner, Hartmut; Buske, Christian; Jongen-Lavrencic, Mojca; Naldini, Luigi; Humphries, R Keith; Kuchenbauer, Florian 2015. MicroRNA-223 dose levels fine tune proliferation and differentiation in human cord blood progenitors and acute myeloid leukemia. Experimental hematology, 43 10, 858-868.e7Rhyasen, G W; Starczynowski, D T 2015. IRAK signalling in cancer. British journal of cancer, 112 2, 232-7Varney ME, Niederkorn M, Konno H, Matsumura T, Gohda J, Yoshida N, Akiyama T, Christie S, Fang J, Miller D, Jerez A, Karsan A, Maciejewski JP, Meetei RA, Inoue J, Starczynowski DT 2015. Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor-TRAF6 signaling Journal of Experimental Medicine, 212 11, 1967Varney, Melinda E; Melgar, Katelyn; Niederkorn, Madeline; Smith, Molly; Barreyro, Laura; Starczynowski, Daniel T 2015. Deconstructing innate immune signaling in myelodysplastic syndromes. Experimental hematology, 43 8, 587-598Varney, Melinda E; Niederkorn, Madeline; Konno, Hiroyasu; Matsumura, Takayuki; Gohda, Jin; Yoshida, Nobuaki; Akiyama, Taishin; Christie, Susanne; Fang, Jing; Miller, David; Jerez, Andres; Karsan, Aly; Maciejewski, Jaroslaw P; Meetei, Ruhikanta A; Inoue, Jun-ichiro; Starczynowski, Daniel T 2015. Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor-TRAF6 signaling. The Journal of experimental medicine, 212 11, 1967-85Beverly, Levil J; Starczynowski, Daniel T 2014. IRAK1: oncotarget in MDS and AML. Oncotarget, 5 7, 1699-700Chang, Kyung Hee; Sengupta, Amitava; Nayak, Ramesh C; Duran, Angeles; Lee, Sang Jun; Pratt, Ronald G; Wellendorf, Ashley M; Hill, Sarah E; Watkins, Marcus; Gonzalez-Nieto, Daniel; Aronow, Bruce J; Starczynowski, Daniel T; Civitelli, Roberto; Diaz-Meco, Maria T; Moscat, Jorge; Cancelas, Jose A 2014. p62 Is Required for Stem Cell/Progenitor Retention through Inhibition of IKK/NF-kappaB/Ccl4 Signaling at the Bone Marrow Macrophage-Osteoblast Niche. Cell reports, 9 6, 2084-97Fang, Jing; Barker, Brenden; Bolanos, Lyndsey; Liu, Xiaona; Jerez, Andres; Makishima, Hideki; Christie, Susanne; Chen, Xiaoting; Rao, Dinesh S; Grimes, H Leighton; Komurov, Kakajan; Weirauch, Matthew T; Cancelas, Jose A; Maciejewski, Jaroslaw P; Starczynowski, Daniel T 2014. Myeloid malignancies with chromosome 5q deletions acquire a dependency on an intrachromosomal NF-kappaB gene network Cell reports, 8 5, 1328-38Rhyasen, G W; Wunderlich, M; Tohyama, K; Garcia-Manero, G; Mulloy, J C; Starczynowski, D T 2014. An MDS xenograft model utilizing a patient-derived cell line. Leukemia, 28 5, 1142-5Starczynowski, Daniel T 2014. Errant innate immune signaling in del(5q) MDS. Blood, 124 5, 669-71Wilson, I M; Vucic, E A; Enfield, K S S; Thu, K L; Zhang, Y A; Chari, R; Lockwood, W W; Radulovich, N; Starczynowski, D T; Banáth, J P; Zhang, M; Pusic, A; Fuller, M; Lonergan, K M; Rowbotham, D; Yee, J; English, J C; Buys, T P H; Selamat, S A; Laird-Offringa, I A; Liu, P; Anderson, M; You, M; Tsao, M S; Brown, C J; Bennewith, K L; MacAulay, C E; Karsan, A; Gazdar, A F; Lam, S; Lam, W L 2014. EYA4 is inactivated biallelically at a high frequency in sporadic lung cancer and is associated with familial lung cancer risk. Oncogene, 33 36, 4464-73Zhao, Jimmy L; Starczynowski, Daniel T 2014. Role of microRNA-146a in normal and malignant hematopoietic stem cell function. Frontiers in genetics, 5 , 219Guo, Fukun; Zhang, Shuangmin; Grogg, Matthew; Cancelas, Jose A; Varney, Melinda E; Starczynowski, Daniel T; Du, Wei; Yang, Jun-Qi; Liu, Wei; Thomas, George; Kozma, Sara; Pang, Qishen; Zheng, Yi 2013. Mouse gene targeting reveals an essential role of mTOR in hematopoietic stem cell engraftment and hematopoiesis. Haematologica, 98 9, 1353-8Rhyasen, Garrett W; Bolanos, Lyndsey; Fang, Jing; Jerez, Andres; Wunderlich, Mark; Rigolino, Carmela; Mathews, Lesley; Ferrer, Marc; Southall, Noel; Guha, Rajarshi; Keller, Jonathan; Thomas, Craig; Beverly, Levi J; Cortelezzi, Agostino; Oliva, Esther N; Cuzzola, Maria; Maciejewski, Jaroslaw P; Mulloy, James C; Starczynowski, Daniel T 2013. Targeting IRAK1 as a therapeutic approach for myelodysplastic syndrome. Cancer cell, 24 1, 90-104Rhyasen, Garrett W; Bolanos, Lyndsey; Starczynowski, Daniel T 2013. Differential IRAK signaling in hematologic malignancies. Experimental hematology, 41 12, 1005-7Fang, Jing; Rhyasen, Garrett; Bolanos, Lyndsey; Rasch, Christopher; Varney, Melinda; Wunderlich, Mark; Goyama, Susumu; Jansen, Gerrit; Cloos, Jacqueline; Rigolino, Carmela; Cortelezzi, Agostino; Mulloy, James C; Oliva, Esther N; Cuzzola, Maria; Starczynowski, Daniel T 2012. Cytotoxic effects of bortezomib in myelodysplastic syndrome/acute myeloid leukemia depend on autophagy-mediated lysosomal degradation of TRAF6 and repression of PSMA1. Blood, 120 4, 858-67Fang, Jing; Varney, Melinda; Starczynowski, Daniel T 2012. Implication of microRNAs in the pathogenesis of MDS. Current pharmaceutical design, 18 22, 3170-9Rhyasen, G W; Starczynowski, D T 2012. Deregulation of microRNAs in myelodysplastic syndrome. Leukemia, 26 1, 13-22Vercauteren, Suzanne M; Starczynowski, Daniel T; Sung, Sandy; McNeil, Kelly; Salski, Chris; Jensen, Clara-Lynn; Bruyere, Helene; Lam, Wan L; Karsan, Aly 2012. T cells of patients with myelodysplastic syndrome are frequently derived from the malignant clone. British journal of haematology, 156 3, 409-12Kuchenbauer, Florian; Mah, Sarah M; Heuser, Michael; McPherson, Andrew; Rüschmann, Jens; Rouhi, Arefeh; Berg, Tobias; Bullinger, Lars; Argiropoulos, Bob; Morin, Ryan D; Lai, David; Starczynowski, Daniel T; Karsan, Aly; Eaves, Connie J; Watahiki, Akira; Wang, Yuzhuo; Aparicio, Samuel A; Ganser, Arnold; Krauter, Jürgen; Döhner, Hartmut; Döhner, Konstanze; Marra, Marco A; Camargo, Fernando D; Palmqvist, Lars; Buske, Christian; Humphries, R Keith 2011. Comprehensive analysis of mammalian miRNA* species and their role in myeloid cells. Blood, 118 12, 3350-8Starczynowski, Daniel T; Kuchenbauer, Florian; Wegrzyn, Joanna; Rouhi, Arefeh; Petriv, Oleh; Hansen, Carl L; Humphries, R Keith; Karsan, Aly 2011. MicroRNA-146a disrupts hematopoietic differentiation and survival. Experimental hematology, 39 2, 167-178.e4Starczynowski, Daniel T; Lockwood, William W; Deléhouzée, Sophie; Chari, Raj; Wegrzyn, Joanna; Fuller, Megan; Tsao, Ming-Sound; Lam, Stephen; Gazdar, Adi F; Lam, Wan L; Karsan, Aly 2011. TRAF6 is an amplified oncogene bridging the RAS and NF-κB pathways in human lung cancer. The Journal of clinical investigation, 121 10, 4095-105Starczynowski, Daniel T; Morin, Ryan; McPherson, Andrew; Lam, Jeff; Chari, Raj; Wegrzyn, Joanna; Kuchenbauer, Florian; Hirst, Martin; Tohyama, Kaoru; Humphries, R Keith; Lam, Wan L; Marra, Marco; Karsan, Aly 2011. Genome-wide identification of human microRNAs located in leukemia-associated genomic alterations. Blood, 117 2, 595-607Starczynowski, Daniel T; Vercauteren, Suzanne; Sung, Sandy; Brooks-Wilson, Angela; Lam, Wan L; Karsan, Aly 2011. Copy number alterations at polymorphic loci may be acquired somatically in patients with myelodysplastic syndromes. Leukemia research, 35 4, 444-7Starczynowski, Daniel T; Karsan, Aly 2010. Innate immune signaling in the myelodysplastic syndromes. Hematology/oncology clinics of North America, 24 2, 343-59Starczynowski, Daniel T; Karsan, Aly 2010. Deregulation of innate immune signaling in myelodysplastic syndromes is associated with deletion of chromosome arm 5q. Cell cycle (Georgetown, Tex.), 9 5, 855-6Starczynowski, Daniel T; Kuchenbauer, Florian; Argiropoulos, Bob; Sung, Sandy; Morin, Ryan; Muranyi, Andrew; Hirst, Martin; Hogge, Donna; Marra, Marco; Wells, Richard A; Buckstein, Rena; Lam, Wan; Humphries, R Keith; Karsan, Aly 2010. Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype. Nature medicine, 16 1, 49-58Vercauteren, Suzanne M; Sung, Sandy; Starczynowski, Daniel T; Lam, Wan L; Bruyere, Helene; Horsman, Douglas E; Tsang, Peter; Leitch, Heather; Karsan, Aly 2010. Array comparative genomic hybridization of peripheral blood granulocytes of patients with myelodysplastic syndrome detects karyotypic abnormalities. American journal of clinical pathology, 134 1, 119-26Starczynowski, Daniel T; Vercauteren, Suzanne; Telenius, Adele; Sung, Sandy; Tohyama, Kaoru; Brooks-Wilson, Angela; Spinelli, John J; Eaves, Connie J; Eaves, Allen C; Horsman, Douglas E; Lam, Wan L; Karsan, Aly 2008. High-resolution whole genome tiling path array CGH analysis of CD34+ cells from patients with low-risk myelodysplastic syndromes reveals cryptic copy number alterations and predicts overall and leukemia-free survival. Blood, 112 8, 3412-24Starczynowski, Daniel T; Reynolds, Joseph G; Gilmore, Thomas D 2005. Mutations of tumor necrosis factor alpha-responsive serine residues within the C-terminal transactivation domain of human transcription factor REL enhance its in vitro transforming ability. Oncogene, 24 49, 7355-68Gilmore, Thomas D; Kalaitzidis, Demetrios; Liang, Mei-Chih; Starczynowski, Daniel T 2004. The c-Rel transcription factor and B-cell proliferation: a deal with the devil. Oncogene, 23 13, 2275-86Gilmore, Thomas D; Starczynowski, Daniel T; Kalaitzidis, Demetrios 2004. RELevant gene amplification in B-cell lymphomas? Blood, 103 8, 3243-4; author replyKalaitzidis, Demetrios; Ok, John; Sulak, Lawrence; Starczynowski, Daniel T; Gilmore, Thomas D 2004. Characterization of a human REL-estrogen receptor fusion protein with a reverse conditional transforming activity in chicken spleen cells. Oncogene, 23 45, 7580-7Leonida, Mihaela D; Starczynowski, Daniel T; Waldman, Riva; Aurian-Blajeni, Benedict 2003. Polymeric FAD used as enzyme-friendly mediator in lactate detection. Analytical and bioanalytical chemistry, 376 6, 832-7Starczynowski, Daniel T; Reynolds, Joseph G; Gilmore, Thomas D 2003. Deletion of either C-terminal transactivation subdomain enhances the in vitro transforming activity of human transcription factor REL in chicken spleen cells. Oncogene, 22 44, 6928-36Gilmore, Thomas; Gapuzan, Maria-Emily; Kalaitzidis, Demetrios; Starczynowski, Daniel 2002. Rel/NF-kappa B/I kappa B signal transduction in the generation and treatment of human cancer. Cancer letters, 181 1, 1-9
Research InterestsThe Starczynowski Lab has an interest in understanding the molecular and cellular basis of hematologic malignancies, with an emphasis on Myelodysplastic Syndromes and Acute Myeloid Leukemia.
Peer Reviewed Publications Laranjeira, Angelo Brunelli Albertoni; Kong, Tim; Snyder, Steven C; Fulbright, Mary C; Fisher, Daniel A C; Starczynowski, Daniel T; Oh, Stephen T 2024. In vivo ablation of NFκB cascade effectors alleviates disease burden in myeloproliferative neoplasms. Blood, , Venkatasubramanian, Meenakshi; Schwartz, Leya; Ramachandra, Nandini; Bennett, Joshua; Subramanian, Krithika R; Chen, Xiaoting; Gordon-Mitchell, Shanisha; Fromowitz, Ariel; Pradhan, Kith; Shechter, David; Sahu, Srabani; Heiser, Diane; Scherle, Peggy; Chetal, Kashish; Kulkarni, Aishwarya; Myers, Kasiani C; Weirauch, Matthew T; Grimes, H Leighton; Starczynowski, Daniel T; Verma, Amit; Salomonis, Nathan 2024. Broad de-regulated U2AF1 splicing is prognostic and augments leukemic transformation via protein arginine methyltransferase activation. bioRxiv : the preprint server for biology, , Bennett, Joshua; Ishikawa, Chiharu; Agarwal, Puneet; Yeung, Jennifer; Sampson, Avery; Uible, Emma; Vick, Eric; Bolanos, Lyndsey C; Hueneman, Kathleen; Wunderlich, Mark; Kolt, Amal; Choi, Kwangmin; Volk, Andrew; Greis, Kenneth D; Rosenbaum, Jan; Hoyt, Scott B; Thomas, Craig J; Starczynowski, Daniel T 2023. Paralog-specific signaling by IRAK1/4 maintains MyD88-independent functions in MDS/AML. Blood, 142 11, 989-1007Bewersdorf, Jan Philipp; Xie, Zhuoer; Bejar, Rafael; Borate, Uma; Boultwood, Jacqueline; Brunner, Andrew M; Buckstein, Rena; Carraway, Hetty E; Churpek, Jane E; Daver, Naval G; Porta, Matteo Giovanni Della; DeZern, Amy E; Fenaux, Pierre; Figueroa, Maria E; Gore, Steven D; Griffiths, Elizabeth A; Halene, Stephanie; Hasserjian, Robert P; Hourigan, Christopher S; Kim, Tae Kon; Komrokji, Rami; Kuchroo, Vijay K; List, Alan F; Loghavi, Sanam; Majeti, Ravindra; Odenike, Olatoyosi; Patnaik, Mrinal M; Platzbecker, Uwe; Roboz, Gail J; Sallman, David A; Santini, Valeria; Sanz, Guillermo; Sekeres, Mikkael A; Stahl, Maximilian; Starczynowski, Daniel T; Steensma, David P; Taylor, Justin; Abdel-Wahab, Omar; Xu, Mina L; Savona, Michael R; Wei, Andrew H; Zeidan, Amer M 2023. Current landscape of translational and clinical research in myelodysplastic syndromes/neoplasms (MDS): Proceedings from the 1st International Workshop on MDS (iwMDS) Of the International Consortium for MDS (icMDS). Blood reviews, 60 , 101072Dean, Sarai T; Ishikawa, Chiharu; Zhu, Xiaoqin; Walulik, Sean; Nixon, Timothy; Jordan, Jessica K; Henderson, Samantha; Wyder, Michael; Salomonis, Nathan; Wunderlich, Mark; Greis, Kenneth D; Starczynowski, Daniel T; Volk, Andrew G 2023. Repression of TRIM13 by chromatin assembly factor CHAF1B is critical for AML development. Blood advances, 7 17, 4822-4837Gorak, Edward J; Otterstatter, Michael; Al Baghdadi, Tareq; Gillis, Nancy; Foran, James M; Liu, Jane Jijun; Bejar, Rafael; Gore, Steven D; Kroft, Steven H; Harrington, Alexandra; Saber, Wael; Starczynowski, Daniel; Rollison, Dana E; Zhang, Ling; Moscinski, Lynn; Wilson, Steffanie; Thompson, Jason; Borchert, Christine; Sherman, Seth; Hebert, Donnie; Walker, Mary Ellen; Padron, Eric; DeZern, Amy E; Sekeres, Mikkael A 2023. Discordant pathologic diagnoses of myelodysplastic neoplasms and their implications for registries and therapies. Blood advances, 7 20, 6120-6129Marion, William; Koppe, Tiago; Chen, Chun-Chin; Wang, Dahai; Frenis, Katie; Fierstein, Sara; Sensharma, Prerana; Aumais, Olivia; Peters, Michael; Ruiz-Torres, Sonya; Chihanga, Tafadzwa; Boettcher, Steffen; Shimamura, Akiko; Bauer, Daniel E; Schlaeger, Thorsten; Wells, Susanne I; Ebert, Benjamin L; Starczynowski, Daniel; da Rocha, Edroaldo Lummertz; Rowe, R Grant 2023. RUNX1 mutations mitigate quiescence to promote transformation of hematopoietic progenitors in Fanconi anemia. Leukemia, 37 8, 1698-1708Muto, Tomoya; Walker, Callum S; Agarwal, Puneet; Vick, Eric; Sampson, Avery; Choi, Kwangmin; Niederkorn, Madeline; Ishikawa, Chiharu; Hueneman, Kathleen; Varney, Melinda; Starczynowski, Daniel T 2023. Inactivation of p53 provides a competitive advantage to del(5q) myelodysplastic syndrome hematopoietic stem cells during inflammation. Haematologica, 108 10, 2715-2729Riabov, Vladimir; Xu, Qingyu; Schmitt, Nanni; Streuer, Alexander; Ge, Guo; Bolanos, Lyndsey; Wunderlich, Mark; Jann, Johann-Christoph; Wein, Alina; Altrock, Eva; Demmerle, Marie; Mukherjee, Sanjay; Ali, Abdullah Mahmood; Rapp, Felicitas; Nowak, Verena; Weimer, Nadine; Obländer, Julia; Palme, Iris; Göl, Melda; Jawhar, Ahmed; Darwich, Ali; Wuchter, Patrick; Weiss, Christel; Raza, Azra; Foulks, Jason M; Starczynowski, Daniel T; Yang, Feng-Chun; Metzgeroth, Georgia; Steiner, Laurenz; Jawhar, Mohamad; Hofmann, Wolf-Karsten; Nowak, Daniel 2023. ASXL1 mutations are associated with a response to alvocidib and 5-azacytidine combination in myelodysplastic neoplasms. Haematologica, , Stahl, Maximilian; Abdel-Wahab, Omar; Wei, Andrew H; Savona, Michael R; Xu, Mina L; Xie, Zhuoer; Taylor, Justin; Starczynowski, Daniel; Sanz, Guillermo F; Sallman, David A; Santini, Valeria; Roboz, Gail J; Patnaik, Mrinal M; Padron, Eric; Odenike, Olatoyosi; Nazha, Aziz; Nimer, Stephen D; Majeti, Ravindra; Little, Richard F; Gore, Steven; List, Alan F; Kutchroo, Vijay; Komrokji, Rami S; Kim, Tae Kon; Kim, Nina; Hourigan, Christopher S; Hasserjian, Robert P; Halene, Stephanie; Griffiths, Elizabeth A; Greenberg, Peter L; Figueroa, Maria; Fenaux, Pierre; Efficace, Fabio; DeZern, Amy E; Della Porta, Matteo G; Daver, Naval G; Churpek, Jane E; Carraway, Hetty E; Brunner, Andrew M; Borate, Uma; Bennett, John M; Bejar, Rafael; Boultwood, Jacqueline; Loghavi, Sanam; Bewersdorf, Jan Philipp; Platzbecker, Uwe; Steensma, David P; Sekeres, Mikkael A; Buckstein, Rena J; Zeidan, Amer M 2023. An agenda to advance research in myelodysplastic syndromes: a TOP 10 priority list from the first international workshop in MDS. Blood advances, 7 12, 2709-2714Stahl, Maximilian; Bewersdorf, Jan Philipp; Xie, Zhuoer; Porta, Matteo Giovanni Della; Komrokji, Rami; Xu, Mina L; Abdel-Wahab, Omar; Taylor, Justin; Steensma, David P; Starczynowski, Daniel T; Sekeres, Mikkael A; Sanz, Guillermo; Sallman, David A; Roboz, Gail J; Platzbecker, Uwe; Patnaik, Mrinal M; Padron, Eric; Odenike, Olatoyosi; Nimer, Stephen D; Nazha, Aziz; Majeti, Ravi; Loghavi, Sanam; Little, Richard F; List, Alan F; Kim, Tae Kon; Hourigan, Christopher S; Hasserjian, Robert P; Halene, Stephanie; Griffiths, Elizabeth A; Gore, Steven D; Greenberg, Peter; Figueroa, Maria E; Fenaux, Pierre; Efficace, Fabio; DeZern, Amy E; Daver, Naval G; Churpek, Jane E; Carraway, Hetty E; Buckstein, Rena; Brunner, Andrew M; Boultwood, Jacqueline; Borate, Uma; Bejar, Rafael; Bennett, John M; Wei, Andrew H; Santini, Valeria; Savona, Michael R; Zeidan, Amer M 2023. Classification, risk stratification and response assessment in myelodysplastic syndromes/neoplasms (MDS): A state-of-the-art report on behalf of the International Consortium for MDS (icMDS). Blood reviews, 62 , 101128Xie, Zhuoer; Starczynowski, Daniel T 2023. Are DDX41 variants of unknown significance and pathogenic variants created equal? Haematologica, 108 11, 2883-2885Aoyagi, Yasushige; Hayashi, Yoshihiro; Harada, Yuka; Choi, Kwangmin; Matsunuma, Natsumi; Sadato, Daichi; Maemoto, Yuki; Ito, Akihiro; Yanagi, Shigeru; Starczynowski, Daniel T; Harada, Hironori 2022. Mitochondrial Fragmentation Triggers Ineffective Hematopoiesis in Myelodysplastic Syndromes. Cancer discovery, 12 1, 250-269Azhar, Mohammad; Kincaid, Zachary; Kesarwani, Meenu; Ahmed, Arhama; Wunderlich, Mark; Latif, Tahir; Starczynowski, Daniel; Azam, Mohammad 2022. Momelotinib is a highly potent inhibitor of FLT3-mutant AML. Blood advances, 6 4, 1186-1192Barreyro, Laura; Sampson, Avery M; Ishikawa, Chiharu; Hueneman, Kathleen M; Choi, Kwangmin; Pujato, Mario A; Chutipongtanate, Somchai; Wyder, Michael; Haffey, Wendy D; O'Brien, Eric; Wunderlich, Mark; Ramesh, Vighnesh; Kolb, Ellen M; Meydan, Cem; Neelamraju, Yaseswini; Bolanos, Lyndsey C; Christie, Susanne; Smith, Molly A; Niederkorn, Madeline; Muto, Tomoya; Kesari, Santosh; Garrett-Bakelman, Francine E; Bartholdy, Boris; Will, Britta; Weirauch, Matthew T; Mulloy, James C; Gul, Zartash; Medlin, Stephen; Kovall, Rhett A; Melnick, Ari M; Perentesis, John P; Greis, Kenneth D; Nurmemmedov, Elmar; Seibel, William L; Starczynowski, Daniel T 2022. Blocking UBE2N abrogates oncogenic immune signaling in acute myeloid leukemia. Science translational medicine, 14 635, eabb7695Bennett, Joshua; Starczynowski, Daniel T 2022. IRAK1 and IRAK4 as emerging therapeutic targets in hematologic malignancies. Current opinion in hematology, 29 1, 8-19Choudhary, Gaurav S; Pellagatti, Andrea; Agianian, Bogos; Smith, Molly A; Bhagat, Tushar D; Gordon-Mitchell, Shanisha; Sahu, Srabani; Pandey, Sanjay; Shah, Nishi; Aluri, Srinivas; Aggarwal, Ritesh; Aminov, Sarah; Schwartz, Leya; Steeples, Violetta; Booher, Robert N; Ramachandra, Murali; Samson, Maria; Carbajal, Milagros; Pradhan, Kith; Bowman, Teresa V; Pillai, Manoj M; Will, Britta; Wickrema, Amittha; Shastri, Aditi; Bradley, Robert K; Martell, Robert E; Steidl, Ulrich G; Gavathiotis, Evripidis; Boultwood, Jacqueline; Starczynowski, Daniel T; Verma, Amit 2022. Activation of targetable inflammatory immune signaling is seen in myelodysplastic syndromes with SF3B1 mutations. eLife, 11 , Jones, LaQuita M; Starczynowski, Daniel T 2022. IKAROS and MENIN in synergy in AML. Nature cancer, 3 5, 528-529Muto, Tomoya; Guillamot, Maria; Yeung, Jennifer; Fang, Jing; Bennett, Joshua; Nadorp, Bettina; Lasry, Audrey; Redondo, Luna Zea; Choi, Kwangmin; Gong, Yixiao; Walker, Callum S; Hueneman, Kathleen; Bolanos, Lyndsey C; Barreyro, Laura; Lee, Lynn H; Greis, Kenneth D; Vasyliev, Nikita; Khodadadi-Jamayran, Alireza; Nudler, Evgeny; Lujambio, Amaia; Lowe, Scott W; Aifantis, Iannis; Starczynowski, Daniel T 2022. TRAF6 functions as a tumor suppressor in myeloid malignancies by directly targeting MYC oncogenic activity. Cell stem cell, 29 2, 298-314.e9Niederkorn, Madeline; Ishikawa, Chiharu; M Hueneman, Kathleen; Bartram, James; Stepanchick, Emily; R Bennett, Joshua; E Culver-Cochran, Ashley; Bolanos, Lyndsey C; Uible, Emma; Choi, Kwangmin; Wunderlich, Mark; Perentesis, John P; M Chlon, Timothy; Filippi, Marie-Dominique; Starczynowski, Daniel T 2022. The deubiquitinase USP15 modulates cellular redox and is a therapeutic target in acute myeloid leukemia. Leukemia, 36 2, 438-451Yeaton, Anna; Cayanan, Geraldine; Loghavi, Sanam; Dolgalev, Igor; Leddin, Emmett M; Loo, Christian E; Torabifard, Hedieh; Nicolet, Deedra; Wang, Jingjing; Corrigan, Kate; Paraskevopoulou, Varvara; Starczynowski, Daniel T; Wang, Eric; Abdel-Wahab, Omar; Viny, Aaron D; Stone, Richard M; Byrd, John C; Guryanova, Olga A; Kohli, Rahul M; Cisneros, G Andrés; Tsirigos, Aristotelis; Eisfeld, Ann-Kathrin; Aifantis, Iannis; Guillamot, Maria 2022. The Impact of Inflammation-Induced Tumor Plasticity during Myeloid Transformation. 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Mutations of tumor necrosis factor alpha-responsive serine residues within the C-terminal transactivation domain of human transcription factor REL enhance its in vitro transforming ability. Oncogene, 24 49, 7355-68Gilmore, Thomas D; Kalaitzidis, Demetrios; Liang, Mei-Chih; Starczynowski, Daniel T 2004. The c-Rel transcription factor and B-cell proliferation: a deal with the devil. Oncogene, 23 13, 2275-86Gilmore, Thomas D; Starczynowski, Daniel T; Kalaitzidis, Demetrios 2004. RELevant gene amplification in B-cell lymphomas? Blood, 103 8, 3243-4; author replyKalaitzidis, Demetrios; Ok, John; Sulak, Lawrence; Starczynowski, Daniel T; Gilmore, Thomas D 2004. Characterization of a human REL-estrogen receptor fusion protein with a reverse conditional transforming activity in chicken spleen cells. Oncogene, 23 45, 7580-7Leonida, Mihaela D; Starczynowski, Daniel T; Waldman, Riva; Aurian-Blajeni, Benedict 2003. Polymeric FAD used as enzyme-friendly mediator in lactate detection. 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A calcium- and calpain-dependent pathway determines the response to lenalidomide in myelodysplastic syndromes Nature Medicine, 22 7, 727Fang, Jing; Liu, Xiaona; Bolanos, Lyndsey; Barker, Brenden; Rigolino, Carmela; Cortelezzi, Agostino; Oliva, Esther N; Cuzzola, Maria; Grimes, H Leighton; Fontanillo, Celia; Komurov, Kakajan; MacBeth, Kyle; Starczynowski, Daniel T 2016. A calcium- and calpain-dependent pathway determines the response to lenalidomide in myelodysplastic syndromes. Nature medicine, 22 7, 727-34Shimizu, Ryo; Muto, Tomoya; Aoyama, Kazumasa; Choi, Kwangmin; Takeuchi, Masahiro; Koide, Shuhei; Hasegawa, Nagisa; Isshiki, Yusuke; Togasaki, Emi; Kawajiri-Manako, Chika; Nagao, Yuhei; Tsukamoto, Shokichi; Sakai, Shio; Takeda, Yusuke; Mimura, Naoya; Ohwada, Chikako; Sakaida, Emiko; Iseki, Tohru; Starczynowski, Daniel T; Iwama, Atsushi; Yokote, Koutaro; Nakaseko, Chiaki 2016. Possible role of intragenic DNA hypermethylation in gene silencing of the tumor suppressor gene NR4A3 in acute myeloid leukemia. Leukemia research, 50 , 85-94Varney ME, Choi K, Bolanos L, Christie S, Fang J, Grimes HL, Maciejewski JP, Inoue JI, Starczynowski DT 2016. Epistasis between TIFAB and miR-146a: neighboring genes in del(5q) myelodysplastic syndrome Leukemia, 50 , 85Adams AK, Bolanos LC, Dexheimer PJ, Karns RA, Aronow BJ, Komurov K, Jegga AG, Casper KA, Patil YJ, Wilson KM, Starczynowski DT, Wells SI 2015. IRAK1 is a novel DEK transcriptional target and is essential for head and neck cancer cell survival Oncotarget, 6 41, 43395Adams, Allie K; Bolanos, Lyndsey C; Dexheimer, Phillip J; Karns, Rebekah A; Aronow, Bruce J; Komurov, Kakajan; Jegga, Anil G; Casper, Keith A; Patil, Yash J; Wilson, Keith M; Starczynowski, Daniel T; Wells, Susanne I 2015. IRAK1 is a novel DEK transcriptional target and is essential for head and neck cancer cell survival. Oncotarget, 6 41, 43395-407Fang, Jing; Starczynowski, Daniel T 2015. Genomic instability establishes dependencies on acquired gene regulatory networks: A novel role of p62 in myeloid malignancies with del(5q). Molecular & cellular oncology, 2 4, e1014219Gañán-Gómez, I; Wei, Y; Starczynowski, D T; Colla, S; Yang, H; Cabrero-Calvo, M; Bohannan, Z S; Verma, A; Steidl, U; Garcia-Manero, G 2015. Deregulation of innate immune and inflammatory signaling in myelodysplastic syndromes. Leukemia, 29 7, 1458-69Gentner, Bernhard; Pochert, Nicole; Rouhi, Arefeh; Boccalatte, Francesco; Plati, Tiziana; Berg, Tobias; Sun, Su Ming; Mah, Sarah M; Mirkovic-Hösle, Milijana; Ruschmann, Jens; Muranyi, Andrew; Leierseder, Simon; Argiropoulos, Bob; Starczynowski, Daniel T; Karsan, Aly; Heuser, Michael; Hogge, Donna; Camargo, Fernando D; Engelhardt, Stefan; Döhner, Hartmut; Buske, Christian; Jongen-Lavrencic, Mojca; Naldini, Luigi; Humphries, R Keith; Kuchenbauer, Florian 2015. MicroRNA-223 dose levels fine tune proliferation and differentiation in human cord blood progenitors and acute myeloid leukemia. Experimental hematology, 43 10, 858-868.e7Rhyasen, G W; Starczynowski, D T 2015. IRAK signalling in cancer. British journal of cancer, 112 2, 232-7Varney ME, Niederkorn M, Konno H, Matsumura T, Gohda J, Yoshida N, Akiyama T, Christie S, Fang J, Miller D, Jerez A, Karsan A, Maciejewski JP, Meetei RA, Inoue J, Starczynowski DT 2015. Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor-TRAF6 signaling Journal of Experimental Medicine, 212 11, 1967Varney, Melinda E; Melgar, Katelyn; Niederkorn, Madeline; Smith, Molly; Barreyro, Laura; Starczynowski, Daniel T 2015. Deconstructing innate immune signaling in myelodysplastic syndromes. Experimental hematology, 43 8, 587-598Varney, Melinda E; Niederkorn, Madeline; Konno, Hiroyasu; Matsumura, Takayuki; Gohda, Jin; Yoshida, Nobuaki; Akiyama, Taishin; Christie, Susanne; Fang, Jing; Miller, David; Jerez, Andres; Karsan, Aly; Maciejewski, Jaroslaw P; Meetei, Ruhikanta A; Inoue, Jun-ichiro; Starczynowski, Daniel T 2015. Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor-TRAF6 signaling. The Journal of experimental medicine, 212 11, 1967-85Beverly, Levil J; Starczynowski, Daniel T 2014. IRAK1: oncotarget in MDS and AML. Oncotarget, 5 7, 1699-700Chang, Kyung Hee; Sengupta, Amitava; Nayak, Ramesh C; Duran, Angeles; Lee, Sang Jun; Pratt, Ronald G; Wellendorf, Ashley M; Hill, Sarah E; Watkins, Marcus; Gonzalez-Nieto, Daniel; Aronow, Bruce J; Starczynowski, Daniel T; Civitelli, Roberto; Diaz-Meco, Maria T; Moscat, Jorge; Cancelas, Jose A 2014. p62 Is Required for Stem Cell/Progenitor Retention through Inhibition of IKK/NF-kappaB/Ccl4 Signaling at the Bone Marrow Macrophage-Osteoblast Niche. Cell reports, 9 6, 2084-97Fang, Jing; Barker, Brenden; Bolanos, Lyndsey; Liu, Xiaona; Jerez, Andres; Makishima, Hideki; Christie, Susanne; Chen, Xiaoting; Rao, Dinesh S; Grimes, H Leighton; Komurov, Kakajan; Weirauch, Matthew T; Cancelas, Jose A; Maciejewski, Jaroslaw P; Starczynowski, Daniel T 2014. Myeloid malignancies with chromosome 5q deletions acquire a dependency on an intrachromosomal NF-kappaB gene network Cell reports, 8 5, 1328-38Rhyasen, G W; Wunderlich, M; Tohyama, K; Garcia-Manero, G; Mulloy, J C; Starczynowski, D T 2014. An MDS xenograft model utilizing a patient-derived cell line. Leukemia, 28 5, 1142-5Starczynowski, Daniel T 2014. Errant innate immune signaling in del(5q) MDS. Blood, 124 5, 669-71Wilson, I M; Vucic, E A; Enfield, K S S; Thu, K L; Zhang, Y A; Chari, R; Lockwood, W W; Radulovich, N; Starczynowski, D T; Banáth, J P; Zhang, M; Pusic, A; Fuller, M; Lonergan, K M; Rowbotham, D; Yee, J; English, J C; Buys, T P H; Selamat, S A; Laird-Offringa, I A; Liu, P; Anderson, M; You, M; Tsao, M S; Brown, C J; Bennewith, K L; MacAulay, C E; Karsan, A; Gazdar, A F; Lam, S; Lam, W L 2014. EYA4 is inactivated biallelically at a high frequency in sporadic lung cancer and is associated with familial lung cancer risk. Oncogene, 33 36, 4464-73Zhao, Jimmy L; Starczynowski, Daniel T 2014. Role of microRNA-146a in normal and malignant hematopoietic stem cell function. Frontiers in genetics, 5 , 219Guo, Fukun; Zhang, Shuangmin; Grogg, Matthew; Cancelas, Jose A; Varney, Melinda E; Starczynowski, Daniel T; Du, Wei; Yang, Jun-Qi; Liu, Wei; Thomas, George; Kozma, Sara; Pang, Qishen; Zheng, Yi 2013. Mouse gene targeting reveals an essential role of mTOR in hematopoietic stem cell engraftment and hematopoiesis. Haematologica, 98 9, 1353-8Rhyasen, Garrett W; Bolanos, Lyndsey; Fang, Jing; Jerez, Andres; Wunderlich, Mark; Rigolino, Carmela; Mathews, Lesley; Ferrer, Marc; Southall, Noel; Guha, Rajarshi; Keller, Jonathan; Thomas, Craig; Beverly, Levi J; Cortelezzi, Agostino; Oliva, Esther N; Cuzzola, Maria; Maciejewski, Jaroslaw P; Mulloy, James C; Starczynowski, Daniel T 2013. Targeting IRAK1 as a therapeutic approach for myelodysplastic syndrome. Cancer cell, 24 1, 90-104Rhyasen, Garrett W; Bolanos, Lyndsey; Starczynowski, Daniel T 2013. Differential IRAK signaling in hematologic malignancies. Experimental hematology, 41 12, 1005-7Fang, Jing; Rhyasen, Garrett; Bolanos, Lyndsey; Rasch, Christopher; Varney, Melinda; Wunderlich, Mark; Goyama, Susumu; Jansen, Gerrit; Cloos, Jacqueline; Rigolino, Carmela; Cortelezzi, Agostino; Mulloy, James C; Oliva, Esther N; Cuzzola, Maria; Starczynowski, Daniel T 2012. Cytotoxic effects of bortezomib in myelodysplastic syndrome/acute myeloid leukemia depend on autophagy-mediated lysosomal degradation of TRAF6 and repression of PSMA1. Blood, 120 4, 858-67Fang, Jing; Varney, Melinda; Starczynowski, Daniel T 2012. Implication of microRNAs in the pathogenesis of MDS. Current pharmaceutical design, 18 22, 3170-9Rhyasen, G W; Starczynowski, D T 2012. Deregulation of microRNAs in myelodysplastic syndrome. Leukemia, 26 1, 13-22Vercauteren, Suzanne M; Starczynowski, Daniel T; Sung, Sandy; McNeil, Kelly; Salski, Chris; Jensen, Clara-Lynn; Bruyere, Helene; Lam, Wan L; Karsan, Aly 2012. T cells of patients with myelodysplastic syndrome are frequently derived from the malignant clone. British journal of haematology, 156 3, 409-12Kuchenbauer, Florian; Mah, Sarah M; Heuser, Michael; McPherson, Andrew; Rüschmann, Jens; Rouhi, Arefeh; Berg, Tobias; Bullinger, Lars; Argiropoulos, Bob; Morin, Ryan D; Lai, David; Starczynowski, Daniel T; Karsan, Aly; Eaves, Connie J; Watahiki, Akira; Wang, Yuzhuo; Aparicio, Samuel A; Ganser, Arnold; Krauter, Jürgen; Döhner, Hartmut; Döhner, Konstanze; Marra, Marco A; Camargo, Fernando D; Palmqvist, Lars; Buske, Christian; Humphries, R Keith 2011. Comprehensive analysis of mammalian miRNA* species and their role in myeloid cells. Blood, 118 12, 3350-8Starczynowski, Daniel T; Kuchenbauer, Florian; Wegrzyn, Joanna; Rouhi, Arefeh; Petriv, Oleh; Hansen, Carl L; Humphries, R Keith; Karsan, Aly 2011. MicroRNA-146a disrupts hematopoietic differentiation and survival. Experimental hematology, 39 2, 167-178.e4Starczynowski, Daniel T; Lockwood, William W; Deléhouzée, Sophie; Chari, Raj; Wegrzyn, Joanna; Fuller, Megan; Tsao, Ming-Sound; Lam, Stephen; Gazdar, Adi F; Lam, Wan L; Karsan, Aly 2011. TRAF6 is an amplified oncogene bridging the RAS and NF-κB pathways in human lung cancer. The Journal of clinical investigation, 121 10, 4095-105Starczynowski, Daniel T; Morin, Ryan; McPherson, Andrew; Lam, Jeff; Chari, Raj; Wegrzyn, Joanna; Kuchenbauer, Florian; Hirst, Martin; Tohyama, Kaoru; Humphries, R Keith; Lam, Wan L; Marra, Marco; Karsan, Aly 2011. Genome-wide identification of human microRNAs located in leukemia-associated genomic alterations. Blood, 117 2, 595-607Starczynowski, Daniel T; Vercauteren, Suzanne; Sung, Sandy; Brooks-Wilson, Angela; Lam, Wan L; Karsan, Aly 2011. Copy number alterations at polymorphic loci may be acquired somatically in patients with myelodysplastic syndromes. Leukemia research, 35 4, 444-7Starczynowski, Daniel T; Karsan, Aly 2010. Innate immune signaling in the myelodysplastic syndromes. Hematology/oncology clinics of North America, 24 2, 343-59Starczynowski, Daniel T; Karsan, Aly 2010. Deregulation of innate immune signaling in myelodysplastic syndromes is associated with deletion of chromosome arm 5q. Cell cycle (Georgetown, Tex.), 9 5, 855-6Starczynowski, Daniel T; Kuchenbauer, Florian; Argiropoulos, Bob; Sung, Sandy; Morin, Ryan; Muranyi, Andrew; Hirst, Martin; Hogge, Donna; Marra, Marco; Wells, Richard A; Buckstein, Rena; Lam, Wan; Humphries, R Keith; Karsan, Aly 2010. Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype. Nature medicine, 16 1, 49-58Vercauteren, Suzanne M; Sung, Sandy; Starczynowski, Daniel T; Lam, Wan L; Bruyere, Helene; Horsman, Douglas E; Tsang, Peter; Leitch, Heather; Karsan, Aly 2010. Array comparative genomic hybridization of peripheral blood granulocytes of patients with myelodysplastic syndrome detects karyotypic abnormalities. American journal of clinical pathology, 134 1, 119-26Starczynowski, Daniel T; Vercauteren, Suzanne; Telenius, Adele; Sung, Sandy; Tohyama, Kaoru; Brooks-Wilson, Angela; Spinelli, John J; Eaves, Connie J; Eaves, Allen C; Horsman, Douglas E; Lam, Wan L; Karsan, Aly 2008. High-resolution whole genome tiling path array CGH analysis of CD34+ cells from patients with low-risk myelodysplastic syndromes reveals cryptic copy number alterations and predicts overall and leukemia-free survival. Blood, 112 8, 3412-24Starczynowski, Daniel T; Reynolds, Joseph G; Gilmore, Thomas D 2005. Mutations of tumor necrosis factor alpha-responsive serine residues within the C-terminal transactivation domain of human transcription factor REL enhance its in vitro transforming ability. Oncogene, 24 49, 7355-68Gilmore, Thomas D; Kalaitzidis, Demetrios; Liang, Mei-Chih; Starczynowski, Daniel T 2004. The c-Rel transcription factor and B-cell proliferation: a deal with the devil. Oncogene, 23 13, 2275-86Gilmore, Thomas D; Starczynowski, Daniel T; Kalaitzidis, Demetrios 2004. RELevant gene amplification in B-cell lymphomas? Blood, 103 8, 3243-4; author replyKalaitzidis, Demetrios; Ok, John; Sulak, Lawrence; Starczynowski, Daniel T; Gilmore, Thomas D 2004. Characterization of a human REL-estrogen receptor fusion protein with a reverse conditional transforming activity in chicken spleen cells. Oncogene, 23 45, 7580-7Leonida, Mihaela D; Starczynowski, Daniel T; Waldman, Riva; Aurian-Blajeni, Benedict 2003. Polymeric FAD used as enzyme-friendly mediator in lactate detection. Analytical and bioanalytical chemistry, 376 6, 832-7Starczynowski, Daniel T; Reynolds, Joseph G; Gilmore, Thomas D 2003. Deletion of either C-terminal transactivation subdomain enhances the in vitro transforming activity of human transcription factor REL in chicken spleen cells. Oncogene, 22 44, 6928-36Gilmore, Thomas; Gapuzan, Maria-Emily; Kalaitzidis, Demetrios; Starczynowski, Daniel 2002. Rel/NF-kappa B/I kappa B signal transduction in the generation and treatment of human cancer. Cancer letters, 181 1, 1-9